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Computational modelling and Epidemiology

Section edited by Michael N. Liebman and Sabrina Molinaro

This section aims to allow rapid communication of methods and results that utilize computational modeling and epidemiologic approaches in translational medicine. The focus will be on population-based studies that extend towards more molecular level analysis. 

Submission of studies involving methods development is encouraged where actual application and results can be shown in the healthcare and life sciences domains. Among the approaches highlighted in this section are data-mining for health impact, data modeling, health record system design, applications of epidemiologic analysis, public policy evaluation, hypothesis evaluation and testing, risk assessment in healthcare and life sciences. These articles will describe the perspective on translational medicine where the approach and results reflect the computational modeling and epidemiologic aspects of this emerging area of research.

Featured articles

Impact of lockdown on Covid-19 case fatality rate and viral mutations spread in 7 countries in Europe and North America

Research | Maria Pachetti et al

Analysis of SARS-CoV-2 RNA-dependent RNA polymerase as a potential therapeutic drug target using a computational approach

Research | Syed Ovais Aftab et al


The effects of statins on dental and oral health: a review of preclinical and clinical studies

Review | Shabnam Tahamtan et al

Page 1 of 6

  1. Clinical data mining of predictive models offers significant advantages for re-evaluating and leveraging large amounts of complex clinical real-world data and experimental comparison data for tasks such as ris...

    Authors: Huimin Qiao, Yijing Chen, Changshun Qian and You Guo
    Citation: Journal of Translational Medicine 2024 22:185
  2. Epilepsy is a common neurological disorder that affects approximately 60 million people worldwide. Characterized by unpredictable neural electrical activity abnormalities, it results in seizures with varying i...

    Authors: Yang Yang, Tianyun Luan, Zhangjun Yu, Min Zhang, Fengtian Li, Xing Chen, Fei Gao and Zhijun Zhang
    Citation: Journal of Translational Medicine 2024 22:162
  3. Telomere length has long been recognized as a valuable biomarker of aging and is inversely correlated with chronological age. Various lifestyle factors have been implicated in telomere shortening or preservati...

    Authors: Miao Chen, Zhen Wang, Hongfei Xu, Peng Teng, Weidong Li and Liang Ma
    Citation: Journal of Translational Medicine 2024 22:160
  4. This study aimed to assess the clinical application of the Artery Occlusion Image Score (AOIS), a new metric based on computed tomographic angiography (CTA) that reflects the severity of occlusive changes in t...

    Authors: Rui Xu, Shixin Peng, Yulong Qiu, Ji Zhu, Xiaodong Zhang and Li Jiang
    Citation: Journal of Translational Medicine 2024 22:152
  5. Advancements in data acquisition and computational methods are generating a large amount of heterogeneous biomedical data from diagnostic domains such as clinical imaging, pathology, and next-generation sequen...

    Authors: Valentina Brancato, Giuseppina Esposito, Luigi Coppola, Carlo Cavaliere, Peppino Mirabelli, Camilla Scapicchio, Rita Borgheresi, Emanuele Neri, Marco Salvatore and Marco Aiello
    Citation: Journal of Translational Medicine 2024 22:136
  6. Fertility preservation treatment is increasingly essential for patients with apical endometrial hyperplasia (AEH) and early endometrial cancer (EEC) worldwide. Complete regression (CR) is the main endpoint of ...

    Authors: Xingchen Li, Yiqin Wang, Jiaqi Wang, Yuan Fan and Jianliu Wang
    Citation: Journal of Translational Medicine 2024 22:127
  7. Multi-omics approaches have been successfully applied to investigate pregnancy and health outcomes at a molecular and genetic level in several studies. As omics technologies advance, research areas are open to...

    Authors: Ali Rahnavard, Ranojoy Chatterjee, Hui Wen, Clark Gaylord, Sabina Mugusi, Kevin C. Klatt and Emily R. Smith
    Citation: Journal of Translational Medicine 2024 22:106
  8. Several large cohort studies in cardiovascular disease (CVD) patients have shown an increased incidence of cancer. Previous studies in a myocardial infarction (MI) mouse model reported increased colon, breast,...

    Authors: Tanawat Attachaipanich, Siriporn C. Chattipakorn and Nipon Chattipakorn
    Citation: Journal of Translational Medicine 2024 22:105
  9. Allergic diseases (ADs) such as asthma are presumed risk factors for COVID-19 infection. However, recent observational studies suggest that the assumed correlation contradicts each other. We therefore systemat...

    Authors: Xiao-tong Chen, Shuai Zhi, Xin-yu Han, Jian-wei Jiang, Guang-ming Liu and Shi-tao Rao
    Citation: Journal of Translational Medicine 2024 22:94
  10. The long-term impact of COVID-19-associated public health interventions on zoonotic and vector-borne infectious diseases (ZVBs) remains uncertain. This study sought to examine the changes in ZVBs in China duri...

    Authors: Yongbin Wang, Siyu Qing, Xianxiang Lan, Lun Li, Peiping Zhou, Yue Xi, Ziyue Liang, Chenguang Zhang and Chunjie Xu
    Citation: Journal of Translational Medicine 2024 22:81
  11. With the increase of aging population and prevalence of obesity, the incidence of cardiovascular disease (CVD) and cancer has also presented an increasing tendency. These two different diseases, which share so...

    Authors: Ming Yang, Tiepeng Li, Shujin Guo, Kangping Song, Chuhui Gong, Ning Huang, Dejiang Pang and Hengyi Xiao
    Citation: Journal of Translational Medicine 2024 22:50
  12. Acute lung injury (ALI) is a complex disease with numerous causes. This review begins with a discussion of disease development from direct or indirect pulmonary insults, as well as varied pathogenesis. The het...

    Authors: Jianguo Zhang, Yumeng Guo, Michael Mak and Zhimin Tao
    Citation: Journal of Translational Medicine 2024 22:25
  13. p value is the most common statistic reported in scientific research articles. Choosing the conventional threshold of 0.05 commonly used for the p value in research articles, is unfounded. Many researchers hav...

    Authors: Farrokh Habibzadeh
    Citation: Journal of Translational Medicine 2024 22:16
  14. Syphilis, a sexually transmitted disease (STD) caused by Treponema pallidum (T. pallidum), has had a worldwide resurgence in recent years and remains a public health threat. As such, there has been a great deal o...

    Authors: Shun Xiong, Zhaoping Liu, Xiaohong Zhang, Shaobin Huang, Xuan Ding, Jie Zhou, Jiangchen Yao, Weiwei Li, Shuangquan Liu and Feijun Zhao
    Citation: Journal of Translational Medicine 2023 21:917
  15. With the development of cancer precision medicine, a huge amount of high-dimensional cancer information has rapidly accumulated regarding gene alterations, diseases, therapeutic interventions and various annot...

    Authors: Wei Jiang, Peng-Ying Wang, Qi Zhou, Qiu-Tong Lin, Yao Yao, Xun Huang, Xiaoming Tan, Shihui Yang, Weicai Ye, Yuedong Yang and Yun-Juan Bao
    Citation: Journal of Translational Medicine 2023 21:885
  16. Asbestos lung content is regarded as the most reliable tool for causal attribution of malignant mesothelioma (MM) to previous asbestos exposures. However, there is a lack of studies on asbestos burden in lungs...

    Authors: S. D. Visonà, B. Bertoglio, C. Favaron, S. Capella, E. Belluso, C. Colosio, S. Villani, T. Ivic-Pavlicic and E. Taioli
    Citation: Journal of Translational Medicine 2023 21:875
  17. The spread of COVID-19 has brought challenges to health, social and economic systems around the world. With little to no prior immunity in the global population, transmission has been driven primarily by human...

    Authors: Jamie D. Mullineaux, Baptiste Leurent and Takoua Jendoubi
    Citation: Journal of Translational Medicine 2023 21:848
  18. Cardiovascular disease (CVD) is a major complication in type 1 diabetes mellitus (T1D) patients. Previous studies have suggested that statins may be helpful for prevention of CVD in T1D, but there are limited ...

    Authors: Joonsang Yoo, Jimin Jeon, Minyoul Baek, Sun Ok Song and Jinkwon Kim
    Citation: Journal of Translational Medicine 2023 21:806
  19. The 70-gene signature (70-GS, MammaPrint) test has been recommended by the main guidelines to evaluate prognosis and chemotherapy benefit of hormonal receptor positive human epidermal receptor 2 negative (HR +...

    Authors: Bo Pan, Ying Xu, Ru Yao, Xi Cao, Xingtong Zhou, Zhixin Hao, Yanna Zhang, Changjun Wang, Songjie Shen, Yanwen Luo, Qingli Zhu, Xinyu Ren, Lingyan Kong, Yidong Zhou and Qiang Sun
    Citation: Journal of Translational Medicine 2023 21:798
  20. Although chronic inflammation, oxidative stress, airway remodeling, and protease-antiprotease imbalance have been implicated in chronic obstructive pulmonary disease (COPD), the exact pathogenesis is still obs...

    Authors: Beibei Li, Jiajun Zhang, Hui Dong, Xueyan Feng, Liang Yu, Jinyuan Zhu and Jin Zhang
    Citation: Journal of Translational Medicine 2023 21:790
  21. Early prevention of Alzheimer’s disease (AD) is a feasible way to delay AD onset and progression. Information on AD prediction at the individual patient level will be useful in AD prevention. In this study, we...

    Authors: Xiao-He Hou, John Suckling, Xue-Ning Shen, Yong Liu, Chuan-Tao Zuo, Yu-Yuan Huang, Hong-Qi Li, Hui-Fu Wang, Chen-Chen Tan, Mei Cui, Qiang Dong, Lan Tan and Jin-Tai Yu
    Citation: Journal of Translational Medicine 2023 21:768
  22. The unfolding protein response is a critical biological process implicated in a variety of physiological functions and disease states across eukaryotes. Despite its significance, the role and underlying mechan...

    Authors: Haiyang Yu, Xiaoyu Ji and Yang Ouyang
    Citation: Journal of Translational Medicine 2023 21:759
  23. Patients with heart failure with reduced ejection fraction (HFrEF) and central sleep apnea (CSA) are at a very high risk of fatal outcomes.

    Authors: David de Gonzalo-Calvo, Pablo Martinez-Camblor, Thalia Belmonte, Ferran Barbé, Kevin Duarte, Martin R. Cowie, Christiane E. Angermann, Andrea Korte, Isabelle Riedel, Josephine Labus, Wolfgang Koenig, Faiez Zannad, Thomas Thum and Christian Bär
    Citation: Journal of Translational Medicine 2023 21:742
  24. This paper addresses the crucial task of identifying DNA/RNA binding sites, which has implications in drug/vaccine design, protein engineering, and cancer research. Existing methods utilize complex neural netw...

    Authors: Saeedeh Akbari Rokn Abadi, SeyedehFatemeh Tabatabaei and Somayyeh Koohi
    Citation: Journal of Translational Medicine 2023 21:727
  25. With the development and popularization of low-dose chest CT technology, the diagnosis and survival rates of patients with early lung cancer (LC) have significantly improved. The occurrence of colorectal cance...

    Authors: Zhihan Xiao, Zichen Wang, Tongyu Zhang, Yi Liu and Mingxuan Si
    Citation: Journal of Translational Medicine 2023 21:722
  26. Epidemiological studies demonstrated that multiple amino acids (AAs) were associated with cardiovascular diseases (CVDs), but whether these associations were causal remains unclear. This study aims to investig...

    Authors: Song Hu, Zhennan Lin, Meng-Jin Hu, Jiang-Shan Tan, Ting-Ting Guo, Xin Huang and Lu Hua
    Citation: Journal of Translational Medicine 2023 21:699
  27. Laryngopharyngeal cancer (LPC) includes laryngeal and hypopharyngeal cancer, whose early diagnosis can significantly improve the prognosis and quality of life of patients. Pathological biopsy of suspicious can...

    Authors: Yun Li, Wenxin Gu, Huijun Yue, Guoqing Lei, Wenbin Guo, Yihui Wen, Haocheng Tang, Xin Luo, Wenjuan Tu, Jin Ye, Ruomei Hong, Qian Cai, Qingyu Gu, Tianrun Liu, Beiping Miao, Ruxin Wang…
    Citation: Journal of Translational Medicine 2023 21:698
  28. Two versions of Framingham’s 10-year risk score are defined for cardiovascular diseases, namely laboratory-based and office-based models. The former is mainly employed in high-income countries, but unfortunate...

    Authors: Azizallah Dehghan, Sajjad Ahmadnia Motlagh, Rozhan Khezri, Fatemeh Rezaei and Dagfinn Aune
    Citation: Journal of Translational Medicine 2023 21:687
  29. Rapid identification of high-risk polytrauma patients is crucial for early intervention and improved outcomes. This study aimed to develop and validate machine learning models for predicting 72 h mortality in ...

    Authors: Wen He, Xianghong Fu and Song Chen
    Citation: Journal of Translational Medicine 2023 21:664
  30. Intracranial aneurysms (IAs) pose a significant and intricate challenge. Elucidating the interplay between DNA methylation and IA pathogenesis is paramount to identify potential biomarkers and therapeutic inte...

    Authors: Aierpati Maimaiti, Mirzat Turhon, Aimitaji Abulaiti, Yilidanna Dilixiati, Fujunhui Zhang, Aximujiang Axieer, Kaheerman Kadeer, Yisen Zhang, Aisha Maimaitili and Xinjian Yang
    Citation: Journal of Translational Medicine 2023 21:660
  31. The interest in targeted cancer therapies has been growing rapidly. While numerous cancer biomarkers and targeted treatment strategies have been developed and employed, there are still significant limitations ...

    Authors: Feihong Ren, Qiubai Jin, Tongtong Liu, Xuelei Ren and Yongli Zhan
    Citation: Journal of Translational Medicine 2023 21:646
  32. Biological ageing is tightly linked to cardiovascular disease (CVD). We aimed to investigate the relationship between Life’s Essential 8 (LE8), a currently updated measure of cardiovascular health (CVH), and b...

    Authors: Ronghuai Zhang, Min Wu, Wei Zhang, Xuna Liu, Jie Pu, Tao Wei, Zhanfang Zhu, Zhiguo Tang, Na Wei, Bo Liu, Qianwei Cui, Junkui Wang, Fuqiang Liu and Ying Lv
    Citation: Journal of Translational Medicine 2023 21:622
  33. A significant proportion of septic patients with acute lung injury (ALI) are recognized late due to the absence of an efficient diagnostic test, leading to the postponed treatments and consequently higher mort...

    Authors: Yongxin Zheng, Jinping Wang, Zhaoyi Ling, Jiamei Zhang, Yuan Zeng, Ke Wang, Yu Zhang, Lingbo Nong, Ling Sang, Yonghao Xu, Xiaoqing Liu, Yimin Li and Yongbo Huang
    Citation: Journal of Translational Medicine 2023 21:620
  34. Assisted reproductive technologies (ART) have increased the incidence of multiple births, which can have a negative impact on maternal and offspring health. The study aimed to investigate the association betwe...

    Authors: Yi Jiang, Yuanyuan Du, Rui Su, Xuan Zhou, Lijie Wei, Jingyi Zhang, Shenglan Zhu, Huiting Zhang, Chenyun Fang, Yuting Chen, Peng Gao, Liangnan Zhang, Shaoshuai Wang, Jun Yu, Mengzhou He, Wencheng Ding…
    Citation: Journal of Translational Medicine 2023 21:608
  35. The influence of the historical cardiovascular risk status on future risk of atherosclerotic cardiovascular disease (ASCVD) is poorly understood. We aimed to investigate the association between 5-year changes ...

    Authors: Jiayi Yi, Lili Wang, Xinli Guo and Xiangpeng Ren
    Citation: Journal of Translational Medicine 2023 21:589
  36. Currently, women around the world are still suffering from various female common diseases with the high incidence, such as ovarian cancer, uterine fibroids and preeclampsia (PE), and some diseases are even wit...

    Authors: Qiang Xu, Mukun Yao and Chao Tang
    Citation: Journal of Translational Medicine 2023 21:583
  37. Alzheimer’s disease (AD) and cancer are common age-related diseases, and epidemiological evidence suggests an inverse relationship between them. However, investigating the potential mechanism underlying their ...

    Authors: Zehua Dong, Mengli Xu, Xu Sun and Xiaosheng Wang
    Citation: Journal of Translational Medicine 2023 21:527
  38. In patients undergoing percutaneous coronary intervention (PCI), contrast-induced acute kidney injury (CIAKI) is a frequent complication, especially in diabetics, and is connected with severe mortality and mor...

    Authors: Mengqing Ma, Xin Wan, Yuyang Chen, Zhichao Lu, Danning Guo, Huiping Kong, Binbin Pan, Hao Zhang, Dawei Chen, Dongxu Xu, Dong Sun, Hong Lang, Changgao Zhou, Tao Li and Changchun Cao
    Citation: Journal of Translational Medicine 2023 21:517
  39. Computational models are increasingly used in high-impact decision making in science, engineering, and medicine. The National Aeronautics and Space Administration (NASA) uses computational models to perform co...

    Authors: Lillian T. Tatka, Lucian P. Smith, Joseph L. Hellerstein and Herbert M. Sauro
    Citation: Journal of Translational Medicine 2023 21:501
  40. The nuclear factor kappa B (NFκB) regulatory pathways downstream of tumor necrosis factor (TNF) play a critical role in carcinogenesis. However, the widespread influence of NFκB in cells can result in off-targ...

    Authors: Yin-Yuan Su, Yu-Ling Liu, Hsuan-Cheng Huang and Chen-Ching Lin
    Citation: Journal of Translational Medicine 2023 21:485
  41. Blood biomarkers for multiple pathways, such as inflammatory response, lipid metabolism, and hormonal regulation, have been suggested to influence the risk of mortality. However, few studies have systematicall...

    Authors: Jing Yang, Jiayi Lu, Junyan Miao, Jiacong Li, Meng Zhu, Juncheng Dai, Hongxia Ma, Guangfu Jin and Dong Hang
    Citation: Journal of Translational Medicine 2023 21:471
  42. The protective effect of a higher ideal cardiovascular health (CVH) score on cardiovascular diseases (CVDs) and mortality is well recognized. However, little is known regarding the length of favorable CVH stat...

    Authors: Qiuyue Tian, Shuohua Chen, Xiaoni Meng, Haotian Wang, Cancan Li, Deqiang Zheng, Lijuan Wu, Aitian Wang, Shouling Wu and Youxin Wang
    Citation: Journal of Translational Medicine 2023 21:469
  43. The prevalence of hyperuricemia, gout, and heart failure (HF) is on the rise, and these conditions often share similar risk factors. The present study aimed to evaluate the relationship among hyperuricemia, go...

    Authors: Yingdong Han, Yu Cao, Xinxin Han, Hong Di, Yue Yin, Juan Wu, Yun Zhang and Xuejun Zeng
    Citation: Journal of Translational Medicine 2023 21:463

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