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Computational modelling and Epidemiology

Section edited by Michael N. Liebman and Sabrina Molinaro

This section aims to allow rapid communication of methods and results that utilize computational modeling and epidemiologic approaches in translational medicine. The focus will be on population-based studies that extend towards more molecular level analysis. Submission of studies involving methods development is encouraged where actual application and results can be shown in the healthcare and life sciences domains. Among the approaches highlighted in this section are data-mining for health impact, data modeling, health record system design, applications of epidemiologic analysis, public policy evaluation, hypothesis evaluation and testing, risk assessment in healthcare and life sciences. These articles will describe the perspective on translational medicine where the approach and results reflect the computational modeling and epidemiologic aspects of this emerging area of research.

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  1. Content type: Review

    Drug development is currently hampered by high attrition rates; many developed treatments fail during clinical testing. Part of the attrition may be due to low animal-to-human translational success rates; so-c...

    Authors: Cathalijn H. C. Leenaars, Carien Kouwenaar, Frans R. Stafleu, André Bleich, Merel Ritskes-Hoitinga, Rob B. M. De Vries and Franck L. B. Meijboom

    Citation: Journal of Translational Medicine 2019 17:223

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  2. Content type: Research

    Tumor necrosis factor α (TNFα) is a multifunctional cytokine with a potent pro-inflammatory effect. It is a validated therapeutic target molecule for several disorders related to autoimmunity and inflammation....

    Authors: Madhu Sudhana Saddala and Hu Huang

    Citation: Journal of Translational Medicine 2019 17:215

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  3. Content type: Research

    Given the benefits of physical activity for health and survival, clinicians are seeking opportunities for cancer patients to become more active independent of rehabilitation programs that are small, time-limit...

    Authors: Catherine M. Sabiston, Angela J. Fong, Erin K. O’Loughlin and Sarkis Meterissian

    Citation: Journal of Translational Medicine 2019 17:206

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  4. Content type: Research

    Serum uric acid (SUA) had been associated with incident hypertension, but it is uncertain whether and to what extent the effect of SUA is mediated by other metabolic factors.

    Authors: Zhi Cao, Yangyang Cheng, Shu Li, Hongxi Yang, Li Sun, Ying Gao, Pei Yu, Weidong Li and Yaogang Wang

    Citation: Journal of Translational Medicine 2019 17:202

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  5. Content type: Research

    Lymph node status and liver metastasis (LIM) are important in determining the prognosis of early colon carcinoma. We attempted to develop and validate nomograms to predict lymph node metastasis (LNM) and LIM i...

    Authors: Yongcong Yan, Haohan Liu, Kai Mao, Mengyu Zhang, Qianlei Zhou, Wei Yu, Bingchao Shi, Jie Wang and Zhiyu Xiao

    Citation: Journal of Translational Medicine 2019 17:193

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  6. Content type: Review

    The aim of the present review is to discuss how the promising field of biobanking can support health care research strategies. As the concept has evolved over time, biobanks have grown from simple biological s...

    Authors: Luigi Coppola, Alessandra Cianflone, Anna Maria Grimaldi, Mariarosaria Incoronato, Paolo Bevilacqua, Francesco Messina, Simona Baselice, Andrea Soricelli, Peppino Mirabelli and Marco Salvatore

    Citation: Journal of Translational Medicine 2019 17:172

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  7. Content type: Research

    Predicting adverse drug reactions (ADRs) has become very important owing to the huge global health burden and failure of drugs. This indicates a need for prior prediction of probable ADRs in preclinical stages...

    Authors: Salma Jamal, Waseem Ali, Priya Nagpal, Sonam Grover and Abhinav Grover

    Citation: Journal of Translational Medicine 2019 17:171

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  8. Content type: Research

    Compared with clinically functioning pituitary adenoma (FPA), clinically non-functioning pituitary adenoma (NFPA) lacks of detectable hypersecreting serum hormones and related symptoms which make it difficult ...

    Authors: Sen Cheng, Jiaqi Wu, Chuzhong Li, Yangfang Li, Chunhui Liu, Guilin Li, Wuju Li, Shuofeng Hu, Xiaomin Ying and Yazhuo Zhang

    Citation: Journal of Translational Medicine 2019 17:164

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  9. Content type: Research

    The morbidity and mortality of patients with critical illnesses remain high in pulmonary critical care units and a poorly understood correlation between alterations of lipid elements and clinical phenomes rema...

    Authors: Danyan Gao, Linlin Zhang, Dongli Song, Jiapei Lv, Linyan Wang, Shuang Zhou, Yanjun Li, Tao Zeng, Yiming Zeng, Jiaqiang Zhang and Xiangdong Wang

    Citation: Journal of Translational Medicine 2019 17:162

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  10. Content type: Research

    Esophageal cancer (EC) is one of the deadliest cancers worldwide. The contemporary strong increase of the adenocarcinomas in Western countries and the high mortality rates require the intensification of prospe...

    Authors: Doris Klingelhöfer, Yun Zhu, Markus Braun, Dörthe Brüggmann, Norman Schöffel and David A. Groneberg

    Citation: Journal of Translational Medicine 2019 17:150

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  11. Content type: Research

    Glioblastomas (GB) are the most common and lethal primary brain tumors. Significant progress has been made toward identifying potential risk factors for GB and diagnostic and prognostic biomarkers. However, th...

    Authors: Anne Clavreul, Gwénaëlle Soulard, Jean-Michel Lemée, Marion Rigot, Pascale Fabbro-Peray, Luc Bauchet, Dominique Figarella-Branger and Philippe Menei

    Citation: Journal of Translational Medicine 2019 17:133

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  12. Content type: Research

    The circadian clock governs a large variety of fundamentally important physiological processes in all three domains of life. Consequently, asynchrony in timekeeping mechanisms could give rise to cellular dysfu...

    Authors: Wai Hoong Chang and Alvina G. Lai

    Citation: Journal of Translational Medicine 2019 17:132

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  13. Content type: Research

    Urinary protein quantification is critical for assessing the severity of chronic kidney disease (CKD). However, the current procedure for determining the severity of CKD is completed through evaluating 24-h ur...

    Authors: Jing Xiao, Ruifeng Ding, Xiulin Xu, Haochen Guan, Xinhui Feng, Tao Sun, Sibo Zhu and Zhibin Ye

    Citation: Journal of Translational Medicine 2019 17:119

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  14. Content type: Research

    Extrahepatic metastasis is the independent risk factor of poor survival of primary hepatic carcinoma (PHC), and most occurs in the chest and abdomen. Currently, there is still no available method to predict th...

    Authors: Jia Hu, Ting Wang, Kun-He Zhang, Yi-Ping Jiang, Song Xu, Si-Hai Chen, Yu-Ting He, Hai-Liang Yuan and Yu-Qi Wang

    Citation: Journal of Translational Medicine 2019 17:117

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  15. Content type: Research

    Chronic hepatitis C virus (HCV)-infection is a slowly debilitating and potentially fatal disease with a high estimated number of undiagnosed cases. Given the major advances in the treatment, detection of unrep...

    Authors: Markus Reiser, Bianka Wiebner and Jürgen Hirsch

    Citation: Journal of Translational Medicine 2019 17:94

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  16. Content type: Research

    Artificial meniscal implants can be used to replace a severely injured meniscus after meniscectomy and restore the normal functionality of a knee joint. The aim of this paper was to design porous meniscal impl...

    Authors: Li-ya Zhu, Lan Li, Zong-an Li, Jian-ping Shi, Wen-lai Tang, Ji-quan Yang and Qing Jiang

    Citation: Journal of Translational Medicine 2019 17:89

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  17. Content type: Research

    Similarities in the symptoms of chronic fatigue syndrome (CFS) and inflammatory bowel disease (IBD) have been observed as follows: severe disease activity in IBD correlates with severe fatigue, major psychiatr...

    Authors: Shin-Yi Tsai, Hsuan-Ju Chen, Chon-Fu Lio, Chien-Feng Kuo, An-Chun Kao, Wei-Shieng Wang, Wei-Cheng Yao, Chi Chen and Tse-Yen Yang

    Citation: Journal of Translational Medicine 2019 17:55

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  18. Content type: Research

    Sequence information generated from next generation sequencing is often computationally phased using haplotype-phasing algorithms. Utilizing experimentally derived allele or haplotype information improves this...

    Authors: Kshitij Srivastava, Kurt R. Wollenberg and Willy A. Flegel

    Citation: Journal of Translational Medicine 2019 17:43

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  19. Content type: Research

    With over 800 million cases globally, campylobacteriosis is a major cause of food borne disease. In temperate climates incidence is highly seasonal but the underlying mechanisms are poorly understood, making h...

    Authors: Stephen P. Rushton, Roy A. Sanderson, Peter J. Diggle, Mark D. F. Shirley, Alasdair P. Blain, Iain Lake, James A. Maas, William D. K. Reid, Jo Hardstaff, Nicola Williams, Natalia R. Jones, Daniel Rigby, Norval J. C. Strachan, Ken J. Forbes, Paul R. Hunter, Thomas J. Humphrey…

    Citation: Journal of Translational Medicine 2019 17:34

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  20. Content type: Research

    Intracranial aneurysms (IAs) are dangerous because of their potential to rupture and cause deadly subarachnoid hemorrhages. Previously, we found significant RNA expression differences in circulating neutrophil...

    Authors: Vincent M. Tutino, Kerry E. Poppenberg, Lu Li, Hussain Shallwani, Kaiyu Jiang, James N. Jarvis, Yijun Sun, Kenneth V. Snyder, Elad I. Levy, Adnan H. Siddiqui, John Kolega and Hui Meng

    Citation: Journal of Translational Medicine 2018 16:373

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  21. Content type: Research

    Increased systemic and local inflammation play a vital role in the pathophysiology of acute coronary syndrome. This study aimed to assess the usefulness of selected machine learning methods and hematological m...

    Authors: Konrad Pieszko, Jarosław Hiczkiewicz, Paweł Budzianowski, Janusz Rzeźniczak, Jan Budzianowski, Jerzy Błaszczyński, Roman Słowiński and Paweł Burchardt

    Citation: Journal of Translational Medicine 2018 16:334

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  22. Content type: Research

    Studies on the relationship between depression and scrub typhus are limited. We conducted a retrospective cohort study to investigate whether scrub typhus is a risk factor for depression.

    Authors: Ying-Chuan Wang, Chun-Hsiang Chiu, Cheng-Li Lin, Feng-You Lee and Kuang-Hsi Chang

    Citation: Journal of Translational Medicine 2018 16:333

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  23. Content type: Research

    Connective tissue growth factor (CTGF), is a secreted matricellular factor that has been linked to increased risk of cardiovascular disease in diabetic subjects. Despite the biological role of CTGF in diabetes...

    Authors: Miran A. Jaffa, Mulugeta Gebregziabher, Sara M. Garrett, Deirdre K. Luttrell, Kenneth E. Lipson, Louis M. Luttrell and Ayad A. Jaffa

    Citation: Journal of Translational Medicine 2018 16:301

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  24. Content type: Research

    Malignant pleural mesothelioma (MPM) is an orphan disease that is difficult to treat using traditional chemotherapy, an approach which has been effective in other types of cancer. Most chemotherapeutics cause ...

    Authors: Kun Tian, Emyr Bakker, Michelle Hussain, Alice Guazzelli, Hasen Alhebshi, Parisa Meysami, Constantinos Demonacos, Jean-Marc Schwartz, Luciano Mutti and Marija Krstic-Demonacos

    Citation: Journal of Translational Medicine 2018 16:282

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  25. Content type: Research

    In the early-life environment, proper development of the placenta is essential for both fetal and maternal health. Telomere length at birth has been related to life expectancy. MicroRNAs (miRNAs) as potential ...

    Authors: Maria Tsamou, Dries S. Martens, Bianca Cox, Narjes Madhloum, Karen Vrijens and Tim S. Nawrot

    Citation: Journal of Translational Medicine 2018 16:254

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  26. Content type: Research

    In this study, we develop reliable and practical virtual coiling and stenting methods for intracranial aneurysm surgical planning. Since the purpose of deploying coils and stents is to provide device geometrie...

    Authors: Xiaochang Leng, Yang Wang, Jing Xu, Yeqing Jiang, Xiaolong Zhang and Jianping Xiang

    Citation: Journal of Translational Medicine 2018 16:208

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  27. Content type: Research

    A model was constructed using clinical and serum variables to discriminate between chronic hepatitis B (CHB) patients with and without significant necroinflammatory activity (score 4–18 vs. score 0–3).

    Authors: Fei-Fei Shen, Yan Wang, Yi-Fei Wang, Rui-Dan Zheng, Jian-Chun Xian, Jun-Ping Shi, Ying Qu, Yu-Wei Dong, Ming-Yi Xu and Lun-Gen Lu

    Citation: Journal of Translational Medicine 2018 16:166

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  28. Content type: Research

    Recent studies have challenged radical procedures for less extensive surgery in selected patients with early-stage cervical cancer at low risk of parametrial invasion. Our objective was to identify a subgroup ...

    Authors: Yohann Dabi, Claire Willecocq, Marcos Ballester, Xavier Carcopino, Sofiane Bendifallah, Lobna Ouldamer, Vincent Lavoue, Geoffroy Canlorbe, Emilie Raimond, Charles Coutant, Olivier Graesslin, Pierre Collinet, Alexandre Bricou, Cyrille Huchon, Emile Daraï, Bassam Haddad…

    Citation: Journal of Translational Medicine 2018 16:163

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  29. Content type: Research

    Pathological scarring in wounds is a prevalent clinical outcome with limited prognostic options. The objective of this study was to investigate whether cellular signaling proteins could be used as prognostic b...

    Authors: Sridevi Nagaraja, Lin Chen, Luisa A. DiPietro, Jaques Reifman and Alexander Y. Mitrophanov

    Citation: Journal of Translational Medicine 2018 16:32

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  30. Content type: Research

    Differences in the concentrations of circulating 25-hydroxyvitamin D [25(OH)D] are associated with a wide range of health outcomes; however, most studies on genetic variants that impact 25(OH)D levels have bee...

    Authors: Massimo Mezzavilla, Sara Tomei, Fadi Alkayal, Motasem Melhem, Maisa M. Ali, Monira Al-Arouj, Abdullah Bennakhi, Osama Alsmadi and Naser Elkum

    Citation: Journal of Translational Medicine 2018 16:20

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  31. Content type: Research

    HIF1α, miR-210 and its downstream targets ISCU, COX-10, RAD52 and PTEN are all part of the placental hypoxia-responsive network. Tight regulation of this network is required to prevent development of maternal–...

    Authors: Karen Vrijens, Maria Tsamou, Narjes Madhloum, Wilfried Gyselaers and Tim S. Nawrot

    Citation: Journal of Translational Medicine 2018 16:2

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  32. Content type: Research

    Chronic kidney disease (CKD) is a growing public health challenges worldwide. Various studies have investigated risk factors of incident CKD; however, a very few studies examined interaction between these risk...

    Authors: Azra Ramezankhani, Maryam Tohidi, Fereidoun Azizi and Farzad Hadaegh

    Citation: Journal of Translational Medicine 2017 15:240

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  33. Content type: Research

    Accumulating clinical researches have shown that specific microbes with abnormal levels are closely associated with the development of various human diseases. Knowledge of microbe–disease associations can prov...

    Authors: Yu-An Huang, Zhu-Hong You, Xing Chen, Zhi-An Huang, Shanwen Zhang and Gui-Ying Yan

    Citation: Journal of Translational Medicine 2017 15:209

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  34. Content type: Research

    Co-circulation of influenza strains is common to seasonal epidemics and pandemic emergence. Competition was considered involved in the vicissitudes of co-circulating influenza strains but never quantitatively ...

    Authors: Bin-Shenq Ho and Kun-Mao Chao

    Citation: Journal of Translational Medicine 2017 15:163

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  35. Content type: Methodology

    Stratified or personalised medicine targets treatments for groups of individuals with a disorder based on individual heterogeneity and shared factors that influence the likelihood of response. Psychiatry has ...

    Authors: Dan W. Joyce, Angie A. Kehagia, Derek K. Tracy, Jessica Proctor and Sukhwinder S. Shergill

    Citation: Journal of Translational Medicine 2017 15:15

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  36. Content type: Research

    The aim of this study was to quantify the effect of the new Low-profile Visualized Intraluminal Support (LVIS®D) device and the difference of fluid diverting effect compared with the Pipeline device and the En...

    Authors: Chao Wang, Zhongbin Tian, Jian Liu, Linkai Jing, Nikhil Paliwal, Shengzhang Wang, Ying Zhang, Jianping Xiang, Adnan H. Siddiqui, Hui Meng and Xinjian Yang

    Citation: Journal of Translational Medicine 2016 14:199

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  37. Content type: Research

    Solid pseudopapillary neoplasms (SPN) are pancreatic tumors with low malignant potential and good prognosis. However, differential diagnosis between SPN and pancreatic malignancies including pancreatic neuroe...

    Authors: Pengping Li, Yuebing Hu, Jiao Yi, Jie Li, Jie Yang and Jin Wang

    Citation: Journal of Translational Medicine 2015 13:361

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  38. Content type: Research

    Telocytes (TCs) are suggested as a new type of interstitial cells with specific telopodes. Our previous study evidenced that TCs differed from fibroblasts and stem cells at the aspect of gene expression profil...

    Authors: Yichun Zhu, Minghuan Zheng, Dongli Song, Ling Ye and Xiangdong Wang

    Citation: Journal of Translational Medicine 2015 13:318

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  39. Content type: Research

    Socioeconomic status (SES) has been focused on as a key determinant of the incidence of cancer, cancer stage at diagnosis as well as treatment choices in western countries. However, to the authors’ knowledge, ...

    Authors: Nana Wang, Fangli Cao, Fang Liu, Yibin Jia, Jianbo Wang, Cihang Bao, Xintong Wang, Qingxu Song, Bingxu Tan and Yufeng Cheng

    Citation: Journal of Translational Medicine 2015 13:241

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  40. Content type: Research

    Renal transplant patients are mandated to have continuous assessment of their kidney function over time to monitor disease progression determined by changes in blood urea nitrogen (BUN), serum creatinine (Cr),...

    Authors: Miran A Jaffa, Mulugeta Gebregziabher and Ayad A Jaffa

    Citation: Journal of Translational Medicine 2015 13:192

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  41. Content type: Methodology

    In the conventional analysis of complex diseases, the control and case samples are assumed to be of great purity. However, due to the heterogeneity of disease samples, many disease genes are even not always co...

    Authors: Xiangtian Yu, Tao Zeng, Xiangdong Wang, Guojun Li and Luonan Chen

    Citation: Journal of Translational Medicine 2015 13:189

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  42. Content type: Methodology

    Cohort studies and registries rely on massive amounts of personal medical data. Therefore, data protection and information security as well as ethical aspects gain in importance and need to be considered as ea...

    Authors: Martin Bialke, Peter Penndorf, Tim Wegner, Thomas Bahls, Christoph Havemann, Jens Piegsa and Wolfgang Hoffmann

    Citation: Journal of Translational Medicine 2015 13:176

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  43. Content type: Methodology

    Cervical lesions caused by integrated human papillomavirus (HPV) infection are highly dangerous because they can quickly develop into invasive cancers. However, clinicians are currently hampered by the lack of...

    Authors: Rong Zhang, Yi-feng He, Mo Chen, Chun-mei Chen, Qiu-jing Zhu, Huan Lu, Zhen-hong Wei, Fang Li, Xiao-xin Zhang, Cong-jian Xu and Long Yu

    Citation: Journal of Translational Medicine 2014 12:282

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