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Computational modelling and Epidemiology

Section edited by Michael N. Liebman and Sabrina Molinaro

This section aims to allow rapid communication of methods and results that utilize computational modeling and epidemiologic approaches in translational medicine. The focus will be on population-based studies that extend towards more molecular level analysis. Submission of studies involving methods development is encouraged where actual application and results can be shown in the healthcare and life sciences domains. Among the approaches highlighted in this section are data-mining for health impact, data modeling, health record system design, applications of epidemiologic analysis, public policy evaluation, hypothesis evaluation and testing, risk assessment in healthcare and life sciences. These articles will describe the perspective on translational medicine where the approach and results reflect the computational modeling and epidemiologic aspects of this emerging area of research.

  1. Content type: Research

    Connective tissue growth factor (CTGF), is a secreted matricellular factor that has been linked to increased risk of cardiovascular disease in diabetic subjects. Despite the biological role of CTGF in diabetes...

    Authors: Miran A. Jaffa, Mulugeta Gebregziabher, Sara M. Garrett, Deirdre K. Luttrell, Kenneth E. Lipson, Louis M. Luttrell and Ayad A. Jaffa

    Citation: Journal of Translational Medicine 2018 16:301

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  2. Content type: Research

    Malignant pleural mesothelioma (MPM) is an orphan disease that is difficult to treat using traditional chemotherapy, an approach which has been effective in other types of cancer. Most chemotherapeutics cause ...

    Authors: Kun Tian, Emyr Bakker, Michelle Hussain, Alice Guazzelli, Hasen Alhebshi, Parisa Meysami, Constantinos Demonacos, Jean-Marc Schwartz, Luciano Mutti and Marija Krstic-Demonacos

    Citation: Journal of Translational Medicine 2018 16:282

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  3. Content type: Research

    In the early-life environment, proper development of the placenta is essential for both fetal and maternal health. Telomere length at birth has been related to life expectancy. MicroRNAs (miRNAs) as potential ...

    Authors: Maria Tsamou, Dries S. Martens, Bianca Cox, Narjes Madhloum, Karen Vrijens and Tim S. Nawrot

    Citation: Journal of Translational Medicine 2018 16:254

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  4. Content type: Research

    In this study, we develop reliable and practical virtual coiling and stenting methods for intracranial aneurysm surgical planning. Since the purpose of deploying coils and stents is to provide device geometrie...

    Authors: Xiaochang Leng, Yang Wang, Jing Xu, Yeqing Jiang, Xiaolong Zhang and Jianping Xiang

    Citation: Journal of Translational Medicine 2018 16:208

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  5. Content type: Research

    A model was constructed using clinical and serum variables to discriminate between chronic hepatitis B (CHB) patients with and without significant necroinflammatory activity (score 4–18 vs. score 0–3).

    Authors: Fei-Fei Shen, Yan Wang, Yi-Fei Wang, Rui-Dan Zheng, Jian-Chun Xian, Jun-Ping Shi, Ying Qu, Yu-Wei Dong, Ming-Yi Xu and Lun-Gen Lu

    Citation: Journal of Translational Medicine 2018 16:166

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  6. Content type: Research

    Recent studies have challenged radical procedures for less extensive surgery in selected patients with early-stage cervical cancer at low risk of parametrial invasion. Our objective was to identify a subgroup ...

    Authors: Yohann Dabi, Claire Willecocq, Marcos Ballester, Xavier Carcopino, Sofiane Bendifallah, Lobna Ouldamer, Vincent Lavoue, Geoffroy Canlorbe, Emilie Raimond, Charles Coutant, Olivier Graesslin, Pierre Collinet, Alexandre Bricou, Cyrille Huchon, Emile Daraï, Bassam Haddad…

    Citation: Journal of Translational Medicine 2018 16:163

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  7. Content type: Research

    Pathological scarring in wounds is a prevalent clinical outcome with limited prognostic options. The objective of this study was to investigate whether cellular signaling proteins could be used as prognostic b...

    Authors: Sridevi Nagaraja, Lin Chen, Luisa A. DiPietro, Jaques Reifman and Alexander Y. Mitrophanov

    Citation: Journal of Translational Medicine 2018 16:32

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  8. Content type: Research

    Differences in the concentrations of circulating 25-hydroxyvitamin D [25(OH)D] are associated with a wide range of health outcomes; however, most studies on genetic variants that impact 25(OH)D levels have bee...

    Authors: Massimo Mezzavilla, Sara Tomei, Fadi Alkayal, Motasem Melhem, Maisa M. Ali, Monira Al-Arouj, Abdullah Bennakhi, Osama Alsmadi and Naser Elkum

    Citation: Journal of Translational Medicine 2018 16:20

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  9. Content type: Research

    HIF1α, miR-210 and its downstream targets ISCU, COX-10, RAD52 and PTEN are all part of the placental hypoxia-responsive network. Tight regulation of this network is required to prevent development of maternal–...

    Authors: Karen Vrijens, Maria Tsamou, Narjes Madhloum, Wilfried Gyselaers and Tim S. Nawrot

    Citation: Journal of Translational Medicine 2018 16:2

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  10. Content type: Research

    Chronic kidney disease (CKD) is a growing public health challenges worldwide. Various studies have investigated risk factors of incident CKD; however, a very few studies examined interaction between these risk...

    Authors: Azra Ramezankhani, Maryam Tohidi, Fereidoun Azizi and Farzad Hadaegh

    Citation: Journal of Translational Medicine 2017 15:240

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  11. Content type: Research

    Accumulating clinical researches have shown that specific microbes with abnormal levels are closely associated with the development of various human diseases. Knowledge of microbe–disease associations can prov...

    Authors: Yu-An Huang, Zhu-Hong You, Xing Chen, Zhi-An Huang, Shanwen Zhang and Gui-Ying Yan

    Citation: Journal of Translational Medicine 2017 15:209

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  12. Content type: Research

    Co-circulation of influenza strains is common to seasonal epidemics and pandemic emergence. Competition was considered involved in the vicissitudes of co-circulating influenza strains but never quantitatively ...

    Authors: Bin-Shenq Ho and Kun-Mao Chao

    Citation: Journal of Translational Medicine 2017 15:163

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  13. Content type: Methodology

    Stratified or personalised medicine targets treatments for groups of individuals with a disorder based on individual heterogeneity and shared factors that influence the likelihood of response. Psychiatry has ...

    Authors: Dan W. Joyce, Angie A. Kehagia, Derek K. Tracy, Jessica Proctor and Sukhwinder S. Shergill

    Citation: Journal of Translational Medicine 2017 15:15

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  14. Content type: Research

    The aim of this study was to quantify the effect of the new Low-profile Visualized Intraluminal Support (LVIS®D) device and the difference of fluid diverting effect compared with the Pipeline device and the En...

    Authors: Chao Wang, Zhongbin Tian, Jian Liu, Linkai Jing, Nikhil Paliwal, Shengzhang Wang, Ying Zhang, Jianping Xiang, Adnan H. Siddiqui, Hui Meng and Xinjian Yang

    Citation: Journal of Translational Medicine 2016 14:199

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  15. Content type: Research

    Solid pseudopapillary neoplasms (SPN) are pancreatic tumors with low malignant potential and good prognosis. However, differential diagnosis between SPN and pancreatic malignancies including pancreatic neuroe...

    Authors: Pengping Li, Yuebing Hu, Jiao Yi, Jie Li, Jie Yang and Jin Wang

    Citation: Journal of Translational Medicine 2015 13:361

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  16. Content type: Research

    Telocytes (TCs) are suggested as a new type of interstitial cells with specific telopodes. Our previous study evidenced that TCs differed from fibroblasts and stem cells at the aspect of gene expression profil...

    Authors: Yichun Zhu, Minghuan Zheng, Dongli Song, Ling Ye and Xiangdong Wang

    Citation: Journal of Translational Medicine 2015 13:318

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  17. Content type: Research

    Socioeconomic status (SES) has been focused on as a key determinant of the incidence of cancer, cancer stage at diagnosis as well as treatment choices in western countries. However, to the authors’ knowledge, ...

    Authors: Nana Wang, Fangli Cao, Fang Liu, Yibin Jia, Jianbo Wang, Cihang Bao, Xintong Wang, Qingxu Song, Bingxu Tan and Yufeng Cheng

    Citation: Journal of Translational Medicine 2015 13:241

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  18. Content type: Research

    Renal transplant patients are mandated to have continuous assessment of their kidney function over time to monitor disease progression determined by changes in blood urea nitrogen (BUN), serum creatinine (Cr),...

    Authors: Miran A Jaffa, Mulugeta Gebregziabher and Ayad A Jaffa

    Citation: Journal of Translational Medicine 2015 13:192

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  19. Content type: Methodology

    In the conventional analysis of complex diseases, the control and case samples are assumed to be of great purity. However, due to the heterogeneity of disease samples, many disease genes are even not always co...

    Authors: Xiangtian Yu, Tao Zeng, Xiangdong Wang, Guojun Li and Luonan Chen

    Citation: Journal of Translational Medicine 2015 13:189

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  20. Content type: Methodology

    Cohort studies and registries rely on massive amounts of personal medical data. Therefore, data protection and information security as well as ethical aspects gain in importance and need to be considered as ea...

    Authors: Martin Bialke, Peter Penndorf, Tim Wegner, Thomas Bahls, Christoph Havemann, Jens Piegsa and Wolfgang Hoffmann

    Citation: Journal of Translational Medicine 2015 13:176

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  21. Content type: Methodology

    Cervical lesions caused by integrated human papillomavirus (HPV) infection are highly dangerous because they can quickly develop into invasive cancers. However, clinicians are currently hampered by the lack of...

    Authors: Rong Zhang, Yi-feng He, Mo Chen, Chun-mei Chen, Qiu-jing Zhu, Huan Lu, Zhen-hong Wei, Fang Li, Xiao-xin Zhang, Cong-jian Xu and Long Yu

    Citation: Journal of Translational Medicine 2014 12:282

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  22. Content type: Research

    Pancreatic ductal adenocarcinoma (PDAC) is an extremely aggressive malignancy, characterized by largely unsatisfactory responses to the currently available therapeutic strategies. In this study we evaluated th...

    Authors: Francesca Tavano, Andrea Fontana, Fabio Pellegrini, Francesca Paola Burbaci, Francesca Rappa, Francesco Cappello, Massimiliano Copetti, Evaristo Maiello, Lucia Lombardi, Paolo Graziano, Manlio Vinciguerra, Fabio Francesco di Mola, Pierluigi di Sebastiano, Angelo Andriulli and Valerio Pazienza

    Citation: Journal of Translational Medicine 2014 12:248

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  23. Content type: Research

    Clozapine is highly effective in treatment-resistant schizophrenia, although, there remains significant variability in the response to this drug. To better understand this variability, the objective of this st...

    Authors: Claire H Li, Robert E Stratford Jr, Nieves Velez de Mendizabal, Thomas IFH Cremers, Bruce G Pollock, Benoit H Mulsant, Gary Remington and Robert R Bies

    Citation: Journal of Translational Medicine 2014 12:203

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  24. Content type: Methodology

    Numerous inflammation-related pathways have been shown to play important roles in atherogenesis. Rapid and efficient assessment of the relative influence of each of those pathways is a challenge in the era of ...

    Authors: Héctor De León, Stéphanie Boué, Walter K Schlage, Natalia Boukharov, Jurjen W Westra, Stephan Gebel, Aaron VanHooser, Marja Talikka, R Brett Fields, Emilija Veljkovic, Michael J Peck, Carole Mathis, Vy Hoang, Carine Poussin, Renee Deehan, Katrin Stolle…

    Citation: Journal of Translational Medicine 2014 12:185

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  25. Content type: Research

    Traditional Chinese Medicine Constitution (TCMC) refers to an integrated, metastable and natural specialty of individual in morphosis, physiological functions and psychological conditions. It is formed on the ...

    Authors: Youzhi Sun, Pei Liu, Yi Zhao, Lei Jia, Yanhua He, Steve An Xue, Xiao Zheng, Zhiyu Wang, Neng Wang and Jianping Chen

    Citation: Journal of Translational Medicine 2014 12:140

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  26. Content type: Research

    Methicillin-resistant Staphylococcus aureus (MRSA) has been a deadly pathogen in healthcare settings since the 1960s, but MRSA epidemiology changed since 1990 with new genetically distinct strain types circulatin...

    Authors: Charles M Macal, Michael J North, Nicholson Collier, Vanja M Dukic, Duane T Wegener, Michael Z David, Robert S Daum, Philip Schumm, James A Evans, Jocelyn R Wilder, Loren G Miller, Samantha J Eells and Diane S Lauderdale

    Citation: Journal of Translational Medicine 2014 12:124

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  27. Content type: Research

    Human diseases frequently cause complications such as obesity-induced diabetes and share numbers of pathological conditions, such as inflammation, by dysfunctions of common functional modules, such as protein–...

    Authors: Hyojung Paik, Hyoung-Sam Heo, Hyo-jeong Ban and Seong Beom Cho

    Citation: Journal of Translational Medicine 2014 12:99

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  28. Content type: Research

    The clinical prediction of survival is among the most challenging tasks because it refers to the process whereby the medical team assimilates clinical data using subjective methods. The purpose of this prospec...

    Authors: Liu Hui, Liu Qigui, Ren Sashuang, Liu Xiliang and Luan Guihong

    Citation: Journal of Translational Medicine 2014 12:78

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  29. Content type: Research

    Each year in China, 30,000 babies are born with congenital hearing impairment. However, the molecular etiology of hearing impairment in the Yunnan Province population where more than 52 minorities live has not...

    Authors: Feng Xin, Yongyi Yuan, Xiaoming Deng, Mingyu Han, Guojian Wang, Jiandong Zhao, Xue Gao, Jun Liu, Fei Yu, Dongyi Han and Pu Dai

    Citation: Journal of Translational Medicine 2013 11:312

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  30. Content type: Methodology

    Integrative understanding of preclinical and clinical data is imperative to enable informed decisions and reduce the attrition rate during drug development. The volume and variety of data generated during drug...

    Authors: Lena Brynne, Anders Bresell and Niclas Sjögren

    Citation: Journal of Translational Medicine 2013 11:250

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  31. Content type: Editorial

    A new section of the Journal of Translational Medicine is being introduced to encourage rapid communication of methods and results that utilize computational modeling and epidemiologic approaches in translational...

    Authors: Michael N Liebman and Sabrina Molinaro

    Citation: Journal of Translational Medicine 2012 10:210

    Published on:

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