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Computational modelling and Epidemiology

Section edited by Michael N. Liebman and Sabrina Molinaro

This section aims to allow rapid communication of methods and results that utilize computational modeling and epidemiologic approaches in translational medicine. The focus will be on population-based studies that extend towards more molecular level analysis. 

Submission of studies involving methods development is encouraged where actual application and results can be shown in the healthcare and life sciences domains. Among the approaches highlighted in this section are data-mining for health impact, data modeling, health record system design, applications of epidemiologic analysis, public policy evaluation, hypothesis evaluation and testing, risk assessment in healthcare and life sciences. These articles will describe the perspective on translational medicine where the approach and results reflect the computational modeling and epidemiologic aspects of this emerging area of research.

Featured articles

Impact of lockdown on Covid-19 case fatality rate and viral mutations spread in 7 countries in Europe and North America

Research | Maria Pachetti et al

Analysis of SARS-CoV-2 RNA-dependent RNA polymerase as a potential therapeutic drug target using a computational approach

Research | Syed Ovais Aftab et al


The effects of statins on dental and oral health: a review of preclinical and clinical studies

Review | Shabnam Tahamtan et al

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  1. A former cohort study has raised concern regarding the unanticipated hazard of omeprazole in expediting osteoarthritis (OA) advancement. The precise nature of their causal evidence, however, remains undetermin...

    Authors: Siyang Cao, Yihao Wei, Yaohang Yue, Guoqing Li, Hongli Wang, Jianjing Lin, Qichang Wang, Peng Liu, Fei Yu, Ao Xiong and Hui Zeng
    Citation: Journal of Translational Medicine 2024 22:504
  2. Patients with alpha-fetoprotein (AFP)-positive hepatocellular carcinoma (HCC) have aggressive biological behavior and poor prognosis. Therefore, survival time is one of the greatest concerns for patients with ...

    Authors: Bingtian Dong, Hua Zhang, Yayang Duan, Senbang Yao, Yongjian Chen and Chaoxue Zhang
    Citation: Journal of Translational Medicine 2024 22:455
  3. Previous literature has explored the relationship between chronic atrophic gastritis (CAG) and isolated cancers within the upper gastrointestinal cancers; However, an integrative synthesis across the totality ...

    Authors: Junqiu Li, Jielu Pan, Dinghong Xiao, Nan Shen, Ruiqing Wang, Hongyv Miao, Peimin Pu, Haiyan Zhang, Xiao Yv and Lianjun Xing
    Citation: Journal of Translational Medicine 2024 22:429
  4. Ischemic heart disease is one of the leading causes of mortality worldwide, and thus calls for development of more effective therapeutic strategies. This study aimed to identify potential therapeutic targets f...

    Authors: Ziyi Sun, Zhangjun Yun, Jianguo Lin, Xiaoning Sun, Qingqing Wang, Jinlong Duan, Cheng Li, Xiaoxiao Zhang, Siyu Xu, Zeqi Wang, Xingjiang Xiong and Kuiwu Yao
    Citation: Journal of Translational Medicine 2024 22:404
  5. Most colorectal cancers originate from precancerous polyps. This study aimed to determine the prevalence of colorectal polyps with diverse pathological morphologies and to explore the risk factors for colorect...

    Authors: Xiaojuan Li, Mengting Hu, Zhangjun Wang, Mei Liu and Ying Chen
    Citation: Journal of Translational Medicine 2024 22:361
  6. Machine learning (ML) methods are increasingly becoming crucial in genome-wide association studies for identifying key genetic variants or SNPs that statistical methods might overlook. Statistical methods pred...

    Authors: Z. Alireza, M. Maleeha, M. Kaikkonen and V. Fortino
    Citation: Journal of Translational Medicine 2024 22:356
  7. Hearing loss has been shown to be a risk factor for psychiatric disorders. In addition, long-term hearing loss is associated with increased hospitalization and mortality rates; however, the increased risk and ...

    Authors: Qun-Yi Nian, Chun-An Cheng, Li-Hsiang Cheng, Yuan-Yung Lin, Chin-Hung Wang, Wu-Chien Chien, Yueng-Hsiang Chu, Cheng-Ping Shih, Chao-Yin Kuo, Hsin-Chien Chen, Jih-Chin Lee, Chi-Hsiang Chung, Wei-Chuan Shangkuan and Hung-Che Lin
    Citation: Journal of Translational Medicine 2024 22:345
  8. Melanocytes are dendritic cells localized in skin, eyes, hair follicles, ears, heart and central nervous system. They are characterized by the presence of melanosomes enriched in melanin which are responsible ...

    Authors: Kelly Coutant, Brice Magne, Karel Ferland, Aurélie Fuentes-Rodriguez, Olivier Chancy, Andrew Mitchell, Lucie Germain and Solange Landreville
    Citation: Journal of Translational Medicine 2024 22:336
  9. Lung adenocarcinoma (LUAD) is the predominant histological subtype of lung cancer and the leading cause of cancer-related mortality. Identifying effective drug targets is crucial for advancing LUAD treatment s...

    Authors: Long Zhang, Yajun Xiong, Jie Zhang, Yuying Feng and Aiguo Xu
    Citation: Journal of Translational Medicine 2024 22:330
  10. Colorectal cancer (CRC) is the third most prevalent cancer globally, and liver metastasis (CRLM) is the primary cause of death. Hence, it is essential to discover novel prognostic biomarkers and therapeutic dr...

    Authors: Xiuman Zhou, Yuzhen Qian, Chen Ling, Zhuoying He, Peishang Shi, Yanfeng Gao and Xinghua Sui
    Citation: Journal of Translational Medicine 2024 22:321
  11. A subset of Graves’ disease (GD) patients develops refractory hyperthyroidism, posing challenges in treatment decisions. The predictive value of baseline characteristics and early therapy indicators in identif...

    Authors: Xinpan Wang, Tiantian Li, Yue Li, Qiuyi Wang, Yun Cai, Zhixiao Wang, Yun Shi, Tao Yang and Xuqin Zheng
    Citation: Journal of Translational Medicine 2024 22:318
  12. Identifying individuals with mild cognitive impairment (MCI) at risk of progressing to Alzheimer’s disease (AD) provides a unique opportunity for early interventions. Therefore, accurate and long-term predicti...

    Authors: Yifan Wang, Ruitian Gao, Ting Wei, Luke Johnston, Xin Yuan, Yue Zhang and Zhangsheng Yu
    Citation: Journal of Translational Medicine 2024 22:265
  13. The term eGene has been applied to define a gene whose expression level is affected by at least one independent expression quantitative trait locus (eQTL). It is both theoretically and empirically important to...

    Authors: Shuo Zhang, Zhou Jiang and Ping Zeng
    Citation: Journal of Translational Medicine 2024 22:258
  14. Tobacco pollutants are prevalent in the environment, leading to inadvertent exposure of pregnant females. Studies of these pollutants' toxic effects on embryonic development have not fully elucidated the poten...

    Authors: Jiasheng Chen, Yuxin Lin, Deyi Gen, Wanxian Chen, Rui Han, Hao Li, Shijie Tang, Shukai Zheng and Xiaoping Zhong
    Citation: Journal of Translational Medicine 2024 22:253
  15. Spontaneous intracerebral hemorrhage (sICH) is associated with significant mortality and morbidity. Predicting the prognosis of patients with sICH remains an important issue, which significantly affects treatm...

    Authors: Zhi Geng, Chaoyi Yang, Ziye Zhao, Yibing Yan, Tao Guo, Chaofan Liu, Aimei Wu, Xingqi Wu, Ling Wei, Yanghua Tian, Panpan Hu and Kai Wang
    Citation: Journal of Translational Medicine 2024 22:236
  16. Accurate and efficient cell grouping is essential for analyzing single-cell transcriptome sequencing (scRNA-seq) data. However, the existing clustering techniques often struggle to provide timely and accurate ...

    Authors: Jun Ren, Xuejing Lyu, Jintao Guo, Xiaodong Shi, Ying Zhou and Qiyuan Li
    Citation: Journal of Translational Medicine 2024 22:233
  17. Cardiovascular diseases (CVDs) are the leading cause of death around the world. Most CVDs-related death can be prevented by the optimal management of risk factors such as unhealthy diet and physical inactivity...

    Authors: Yun Qian, Jing-Yu (Benjamin) Tan, Tao Wang, Daniel Bressington, Hong-Juan Zhou, Meng-Yuan Li and Xian-Liang Liu
    Citation: Journal of Translational Medicine 2024 22:215
  18. Clinical data mining of predictive models offers significant advantages for re-evaluating and leveraging large amounts of complex clinical real-world data and experimental comparison data for tasks such as ris...

    Authors: Huimin Qiao, Yijing Chen, Changshun Qian and You Guo
    Citation: Journal of Translational Medicine 2024 22:185
  19. Epilepsy is a common neurological disorder that affects approximately 60 million people worldwide. Characterized by unpredictable neural electrical activity abnormalities, it results in seizures with varying i...

    Authors: Yang Yang, Tianyun Luan, Zhangjun Yu, Min Zhang, Fengtian Li, Xing Chen, Fei Gao and Zhijun Zhang
    Citation: Journal of Translational Medicine 2024 22:162
  20. Telomere length has long been recognized as a valuable biomarker of aging and is inversely correlated with chronological age. Various lifestyle factors have been implicated in telomere shortening or preservati...

    Authors: Miao Chen, Zhen Wang, Hongfei Xu, Peng Teng, Weidong Li and Liang Ma
    Citation: Journal of Translational Medicine 2024 22:160
  21. This study aimed to assess the clinical application of the Artery Occlusion Image Score (AOIS), a new metric based on computed tomographic angiography (CTA) that reflects the severity of occlusive changes in t...

    Authors: Rui Xu, Shixin Peng, Yulong Qiu, Ji Zhu, Xiaodong Zhang and Li Jiang
    Citation: Journal of Translational Medicine 2024 22:152
  22. Advancements in data acquisition and computational methods are generating a large amount of heterogeneous biomedical data from diagnostic domains such as clinical imaging, pathology, and next-generation sequen...

    Authors: Valentina Brancato, Giuseppina Esposito, Luigi Coppola, Carlo Cavaliere, Peppino Mirabelli, Camilla Scapicchio, Rita Borgheresi, Emanuele Neri, Marco Salvatore and Marco Aiello
    Citation: Journal of Translational Medicine 2024 22:136
  23. Fertility preservation treatment is increasingly essential for patients with apical endometrial hyperplasia (AEH) and early endometrial cancer (EEC) worldwide. Complete regression (CR) is the main endpoint of ...

    Authors: Xingchen Li, Yiqin Wang, Jiaqi Wang, Yuan Fan and Jianliu Wang
    Citation: Journal of Translational Medicine 2024 22:127
  24. Multi-omics approaches have been successfully applied to investigate pregnancy and health outcomes at a molecular and genetic level in several studies. As omics technologies advance, research areas are open to...

    Authors: Ali Rahnavard, Ranojoy Chatterjee, Hui Wen, Clark Gaylord, Sabina Mugusi, Kevin C. Klatt and Emily R. Smith
    Citation: Journal of Translational Medicine 2024 22:106
  25. Several large cohort studies in cardiovascular disease (CVD) patients have shown an increased incidence of cancer. Previous studies in a myocardial infarction (MI) mouse model reported increased colon, breast,...

    Authors: Tanawat Attachaipanich, Siriporn C. Chattipakorn and Nipon Chattipakorn
    Citation: Journal of Translational Medicine 2024 22:105
  26. Allergic diseases (ADs) such as asthma are presumed risk factors for COVID-19 infection. However, recent observational studies suggest that the assumed correlation contradicts each other. We therefore systemat...

    Authors: Xiao-tong Chen, Shuai Zhi, Xin-yu Han, Jian-wei Jiang, Guang-ming Liu and Shi-tao Rao
    Citation: Journal of Translational Medicine 2024 22:94
  27. The long-term impact of COVID-19-associated public health interventions on zoonotic and vector-borne infectious diseases (ZVBs) remains uncertain. This study sought to examine the changes in ZVBs in China duri...

    Authors: Yongbin Wang, Siyu Qing, Xianxiang Lan, Lun Li, Peiping Zhou, Yue Xi, Ziyue Liang, Chenguang Zhang and Chunjie Xu
    Citation: Journal of Translational Medicine 2024 22:81
  28. With the increase of aging population and prevalence of obesity, the incidence of cardiovascular disease (CVD) and cancer has also presented an increasing tendency. These two different diseases, which share so...

    Authors: Ming Yang, Tiepeng Li, Shujin Guo, Kangping Song, Chuhui Gong, Ning Huang, Dejiang Pang and Hengyi Xiao
    Citation: Journal of Translational Medicine 2024 22:50
  29. Acute lung injury (ALI) is a complex disease with numerous causes. This review begins with a discussion of disease development from direct or indirect pulmonary insults, as well as varied pathogenesis. The het...

    Authors: Jianguo Zhang, Yumeng Guo, Michael Mak and Zhimin Tao
    Citation: Journal of Translational Medicine 2024 22:25
  30. p value is the most common statistic reported in scientific research articles. Choosing the conventional threshold of 0.05 commonly used for the p value in research articles, is unfounded. Many researchers hav...

    Authors: Farrokh Habibzadeh
    Citation: Journal of Translational Medicine 2024 22:16
  31. Syphilis, a sexually transmitted disease (STD) caused by Treponema pallidum (T. pallidum), has had a worldwide resurgence in recent years and remains a public health threat. As such, there has been a great deal o...

    Authors: Shun Xiong, Zhaoping Liu, Xiaohong Zhang, Shaobin Huang, Xuan Ding, Jie Zhou, Jiangchen Yao, Weiwei Li, Shuangquan Liu and Feijun Zhao
    Citation: Journal of Translational Medicine 2023 21:917
  32. With the development of cancer precision medicine, a huge amount of high-dimensional cancer information has rapidly accumulated regarding gene alterations, diseases, therapeutic interventions and various annot...

    Authors: Wei Jiang, Peng-Ying Wang, Qi Zhou, Qiu-Tong Lin, Yao Yao, Xun Huang, Xiaoming Tan, Shihui Yang, Weicai Ye, Yuedong Yang and Yun-Juan Bao
    Citation: Journal of Translational Medicine 2023 21:885
  33. Asbestos lung content is regarded as the most reliable tool for causal attribution of malignant mesothelioma (MM) to previous asbestos exposures. However, there is a lack of studies on asbestos burden in lungs...

    Authors: S. D. Visonà, B. Bertoglio, C. Favaron, S. Capella, E. Belluso, C. Colosio, S. Villani, T. Ivic-Pavlicic and E. Taioli
    Citation: Journal of Translational Medicine 2023 21:875
  34. The spread of COVID-19 has brought challenges to health, social and economic systems around the world. With little to no prior immunity in the global population, transmission has been driven primarily by human...

    Authors: Jamie D. Mullineaux, Baptiste Leurent and Takoua Jendoubi
    Citation: Journal of Translational Medicine 2023 21:848
  35. Cardiovascular disease (CVD) is a major complication in type 1 diabetes mellitus (T1D) patients. Previous studies have suggested that statins may be helpful for prevention of CVD in T1D, but there are limited ...

    Authors: Joonsang Yoo, Jimin Jeon, Minyoul Baek, Sun Ok Song and Jinkwon Kim
    Citation: Journal of Translational Medicine 2023 21:806
  36. The 70-gene signature (70-GS, MammaPrint) test has been recommended by the main guidelines to evaluate prognosis and chemotherapy benefit of hormonal receptor positive human epidermal receptor 2 negative (HR +...

    Authors: Bo Pan, Ying Xu, Ru Yao, Xi Cao, Xingtong Zhou, Zhixin Hao, Yanna Zhang, Changjun Wang, Songjie Shen, Yanwen Luo, Qingli Zhu, Xinyu Ren, Lingyan Kong, Yidong Zhou and Qiang Sun
    Citation: Journal of Translational Medicine 2023 21:798
  37. Although chronic inflammation, oxidative stress, airway remodeling, and protease-antiprotease imbalance have been implicated in chronic obstructive pulmonary disease (COPD), the exact pathogenesis is still obs...

    Authors: Beibei Li, Jiajun Zhang, Hui Dong, Xueyan Feng, Liang Yu, Jinyuan Zhu and Jin Zhang
    Citation: Journal of Translational Medicine 2023 21:790
  38. Early prevention of Alzheimer’s disease (AD) is a feasible way to delay AD onset and progression. Information on AD prediction at the individual patient level will be useful in AD prevention. In this study, we...

    Authors: Xiao-He Hou, John Suckling, Xue-Ning Shen, Yong Liu, Chuan-Tao Zuo, Yu-Yuan Huang, Hong-Qi Li, Hui-Fu Wang, Chen-Chen Tan, Mei Cui, Qiang Dong, Lan Tan and Jin-Tai Yu
    Citation: Journal of Translational Medicine 2023 21:768
  39. The unfolding protein response is a critical biological process implicated in a variety of physiological functions and disease states across eukaryotes. Despite its significance, the role and underlying mechan...

    Authors: Haiyang Yu, Xiaoyu Ji and Yang Ouyang
    Citation: Journal of Translational Medicine 2023 21:759
  40. Patients with heart failure with reduced ejection fraction (HFrEF) and central sleep apnea (CSA) are at a very high risk of fatal outcomes.

    Authors: David de Gonzalo-Calvo, Pablo Martinez-Camblor, Thalia Belmonte, Ferran Barbé, Kevin Duarte, Martin R. Cowie, Christiane E. Angermann, Andrea Korte, Isabelle Riedel, Josephine Labus, Wolfgang Koenig, Faiez Zannad, Thomas Thum and Christian Bär
    Citation: Journal of Translational Medicine 2023 21:742
  41. This paper addresses the crucial task of identifying DNA/RNA binding sites, which has implications in drug/vaccine design, protein engineering, and cancer research. Existing methods utilize complex neural netw...

    Authors: Saeedeh Akbari Rokn Abadi, SeyedehFatemeh Tabatabaei and Somayyeh Koohi
    Citation: Journal of Translational Medicine 2023 21:727
  42. With the development and popularization of low-dose chest CT technology, the diagnosis and survival rates of patients with early lung cancer (LC) have significantly improved. The occurrence of colorectal cance...

    Authors: Zhihan Xiao, Zichen Wang, Tongyu Zhang, Yi Liu and Mingxuan Si
    Citation: Journal of Translational Medicine 2023 21:722
  43. Epidemiological studies demonstrated that multiple amino acids (AAs) were associated with cardiovascular diseases (CVDs), but whether these associations were causal remains unclear. This study aims to investig...

    Authors: Song Hu, Zhennan Lin, Meng-Jin Hu, Jiang-Shan Tan, Ting-Ting Guo, Xin Huang and Lu Hua
    Citation: Journal of Translational Medicine 2023 21:699
  44. Laryngopharyngeal cancer (LPC) includes laryngeal and hypopharyngeal cancer, whose early diagnosis can significantly improve the prognosis and quality of life of patients. Pathological biopsy of suspicious can...

    Authors: Yun Li, Wenxin Gu, Huijun Yue, Guoqing Lei, Wenbin Guo, Yihui Wen, Haocheng Tang, Xin Luo, Wenjuan Tu, Jin Ye, Ruomei Hong, Qian Cai, Qingyu Gu, Tianrun Liu, Beiping Miao, Ruxin Wang…
    Citation: Journal of Translational Medicine 2023 21:698

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