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Computational modelling and Epidemiology

Section edited by Michael N. Liebman and Sabrina Molinaro

This section aims to allow rapid communication of methods and results that utilize computational modeling and epidemiologic approaches in translational medicine. The focus will be on population-based studies that extend towards more molecular level analysis. 

Submission of studies involving methods development is encouraged where actual application and results can be shown in the healthcare and life sciences domains. Among the approaches highlighted in this section are data-mining for health impact, data modeling, health record system design, applications of epidemiologic analysis, public policy evaluation, hypothesis evaluation and testing, risk assessment in healthcare and life sciences. These articles will describe the perspective on translational medicine where the approach and results reflect the computational modeling and epidemiologic aspects of this emerging area of research.

Featured articles

Impact of lockdown on Covid-19 case fatality rate and viral mutations spread in 7 countries in Europe and North America

Research | Maria Pachetti et al

Analysis of SARS-CoV-2 RNA-dependent RNA polymerase as a potential therapeutic drug target using a computational approach

Research | Syed Ovais Aftab et al

The effects of statins on dental and oral health: a review of preclinical and clinical studies

Review | Shabnam Tahamtan et al

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  1. The growing epidemic of the inflammation-related metabolic disease, type 2 diabetes mellitus, presents a challenge to improve our understanding of potential mechanisms or biomarkers to prevent or better contro...

    Authors: Nicole Noren Hooten, Nicolle A. Mode, Edward Kowalik, Victor Omoniyi, Alan B. Zonderman, Ngozi Ezike, Mark J. DiNubile, Susan L. Levinson and Michele K. Evans
    Citation: Journal of Translational Medicine 2023 21:190
  2. Circadian rhythm regulates complex physiological activities in organisms. A strong link between circadian dysfunction and cancer has been identified. However, the factors of dysregulation and functional signif...

    Authors: Yuwei Liu, Shuang Guo, Yue Sun, Caiyu Zhang, Jing Gan, Shangwei Ning and Junwei Wang
    Citation: Journal of Translational Medicine 2023 21:185
  3. Gastric cancer (GC) is a major cancer burden throughout the world with a high mortality rate. The performance of current predictive and prognostic factors is still limited. Integrated analysis is required for ...

    Authors: Wenying Yan, Yuqi Chen, Guang Hu, Tongguo Shi, Xingyi Liu, Juntao Li, Linqing Sun, Fuliang Qian and Weichang Chen
    Citation: Journal of Translational Medicine 2023 21:163
  4. The United Nations recently made a call to address the challenges of an estimated 300 million persons worldwide living with a rare disease through the collection, analysis, and dissemination of disaggregated d...

    Authors: William Z. Kariampuzha, Gioconda Alyea, Sue Qu, Jaleal Sanjak, Ewy Mathé, Eric Sid, Haley Chatelaine, Arjun Yadaw, Yanji Xu and Qian Zhu
    Citation: Journal of Translational Medicine 2023 21:157
  5. Complex diseases often present as a diagnosis riddle, further complicated by the combination of multiple phenotypes and diseases as features of other diseases. With the aim of enhancing the determination of ke...

    Authors: Lynn M. Schriml, Richard Lichenstein, Katharine Bisordi, Cynthia Bearer, J. Allen Baron and Carol Greene
    Citation: Journal of Translational Medicine 2023 21:148
  6. To explore the possibility of kidney organoids generated using patient derived human induced pluripotent stem cells (hiPSC) for modeling of Fabry disease nephropathy (FDN).

    Authors: Sheng Cui, Xianying Fang, Hanbi Lee, Yoo Jin Shin, Eun-Sil Koh, Sungjin Chung, Hoon Suk Park, Sun Woo Lim, Kang In Lee, Jae Young Lee, Chul Woo Yang and Byung Ha Chung
    Citation: Journal of Translational Medicine 2023 21:138
  7. Fibroblast growth factor receptor 3 is known as a favorable aim in vast range of cancers, particularly in bladder cancer treatment. Pharmacophore and QSAR modeling approaches are broadly utilized for developin...

    Authors: Mahmoud Ganji, Shohreh Bakhshi, Alireza Shoari and Reza Ahangari Cohan
    Citation: Journal of Translational Medicine 2023 21:111
  8. Length of stay (LOS) is an important metric for evaluating the management of inpatients. This study aimed to explore the factors impacting the LOS of inpatients with type-2 diabetes mellitus (T2DM) and develop...

    Authors: Juntao Tan, Zhengyu Zhang, Yuxin He, Yue Yu, Jing Zheng, Yunyu Liu, Jun Gong, Jianjun Li, Xin Wu, Shengying Zhang, Xiantian Lin, Yuxi Zhao, Xiaoxin Wu, Songjia Tang, Jingjing Chen and Wenlong Zhao
    Citation: Journal of Translational Medicine 2023 21:91
  9. Identifying candidates responsive to treatment is important in lupus nephritis (LN) at the renal flare (RF) because an effective treatment can lower the risk of progression to end-stage kidney disease. However...

    Authors: Ding-Jie Lee, Ping-Huang Tsai, Chien-Chou Chen and Yang-Hong Dai
    Citation: Journal of Translational Medicine 2023 21:76
  10. Drug-target interaction (DTI) prediction has become a crucial prerequisite in drug design and drug discovery. However, the traditional biological experiment is time-consuming and expensive, as there are abunda...

    Authors: Zhong-Hao Ren, Zhu-Hong You, Quan Zou, Chang-Qing Yu, Yan-Fang Ma, Yong-Jian Guan, Hai-Ru You, Xin-Fei Wang and Jie Pan
    Citation: Journal of Translational Medicine 2023 21:48
  11. Accurate pathological diagnosis of invasion depth and histologic grade is key for clinical management in patients with bladder cancer (BCa), but it is labour-intensive, experience-dependent and subject to inte...

    Authors: Jiexin Pan, Guibin Hong, Hong Zeng, Chengxiao Liao, Huarun Li, Yuhui Yao, Qinghua Gan, Yun Wang, Shaoxu Wu and Tianxin Lin
    Citation: Journal of Translational Medicine 2023 21:42
  12. Recent studies have identified DNA replication stress as an important feature of advanced prostate cancer (PCa). The identification of biomarkers for DNA replication stress could therefore facilitate risk stra...

    Authors: Rong-Hua Huang, Ying-Kai Hong, Heng Du, Wei-Qi Ke, Bing-Biao Lin and Ya-Lan Li
    Citation: Journal of Translational Medicine 2023 21:20
  13. In drug development, few molecules from a large pool of early candidates become successful medicines after demonstrating a favourable benefit-risk ratio. Many decisions are made along the way to continue or st...

    Authors: Chao Chen, Xuan Zhou, Silvia Maria Lavezzi, Usman Arshad and Raman Sharma
    Citation: Journal of Translational Medicine 2023 21:17
  14. Ophthalmic epidemiology is concerned with the prevalence, distribution and other factors relating to human eye disease. While observational studies cannot avoid confounding factors from interventions, human ey...

    Authors: Jiaxin Li, Cong Li, Yu Huang, Peng Guan, Desheng Huang, Honghua Yu, Xiaohong Yang and Lei Liu
    Citation: Journal of Translational Medicine 2022 20:621
  15. Bloodstream infection (BSI) is a significant cause of mortality among patients with fever of unknown origin (FUO). Inappropriate empiric antimicrobial therapy increases difficulty in BSI diagnosis and treatmen...

    Authors: Teng Xu, Shi Wu, Jingwen Li, Li Wang and Haihui Huang
    Citation: Journal of Translational Medicine 2022 20:575
  16. In observational studies, testosterone has been reported to be associated with some types of cancers. However, the direction and magnitude of the causal association between testosterone and different types of ...

    Authors: Junke Chang, Yongming Wu, Sicheng Zhou, Ye Tian, Yan Wang, Jie Tian, Wenpeng Song, Yinxian Dong, Jue Li, Ziyi Zhao and Guowei Che
    Citation: Journal of Translational Medicine 2022 20:573
  17. The coronavirus disease 2019 (COVID-19) severely hindered the timely receipt of health care for patients with cancer, especially female patients. Depression and anxiety were more pronounced in female patients ...

    Authors: Yu Min, Zheran Liu, Rendong Huang, Ruidan Li, Jing Jin, Zhigong Wei, Ling He, Yiyan Pei, Ning Li, Yongllin Su, Xiaolin Hu and Xingchen Peng
    Citation: Journal of Translational Medicine 2022 20:560
  18. Associations of drugs with diseases provide important information for expediting drug development. Due to the number of known drug-disease associations is still insufficient, and considering that inferring ass...

    Authors: Mei-Neng Wang, Xue-Jun Xie, Zhu-Hong You, De-Wu Ding and Leon Wong
    Citation: Journal of Translational Medicine 2022 20:552
  19. Gene editing has great potential in treating diseases caused by well-characterized molecular alterations. The introduction of clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associate...

    Authors: Ajaz A. Bhat, Sabah Nisar, Soumi Mukherjee, Nirmalya Saha, Nageswari Yarravarapu, Saife N. Lone, Tariq Masoodi, Ravi Chauhan, Selma Maacha, Puneet Bagga, Punita Dhawan, Ammira Al-Shabeeb Akil, Wael El-Rifai, Shahab Uddin, Ravinder Reddy, Mayank Singh…
    Citation: Journal of Translational Medicine 2022 20:534
  20. Despite a recent increase in the number of RNA-seq datasets investigating heart failure (HF), accessibility and usability remain critical issues for medical researchers. We address the need for an intuitive an...

    Authors: Thiago Britto-Borges, Annekathrin Ludt, Etienne Boileau, Enio Gjerga, Federico Marini and Christoph Dieterich
    Citation: Journal of Translational Medicine 2022 20:513
  21. The low number of patients suffering from any given rare diseases poses a difficult problem for medical research: With the exception of some specialized biobanks and disease registries, potential study partici...

    Authors: Tobias Kussel, Torben Brenner, Galina Tremper, Josef Schepers, Martin Lablans and Kay Hamacher
    Citation: Journal of Translational Medicine 2022 20:458
  22. With the development of digital pathology and the renewal of deep learning algorithm, artificial intelligence (AI) is widely applied in tumor pathology. Previous researches have demonstrated that AI-based tumo...

    Authors: Zefeng Shen, Jintao Hu, Haiyang Wu, Zeshi Chen, Weixia Wu, Junyi Lin, Zixin Xu, Jianqiu Kong and Tianxin Lin
    Citation: Journal of Translational Medicine 2022 20:409
  23. Second primary malignancy (SPM) represents the leading long-term cause of death among patients with index head and neck squamous cell carcinoma (HNSCC). We aimed to quantify the association between postoperati...

    Authors: Xiaoke Zhu, Jian Zhou, Liang Zhou, Ming Zhang, Chunli Gao and Lei Tao
    Citation: Journal of Translational Medicine 2022 20:405
  24. The immune system plays a vital role in the pathological process of ischaemic stroke. However, the exact immune-related mechanism remains unclear. The current research aimed to identify immune-related key gene...

    Authors: Peng-Fei Zheng, Lu-Zhu Chen, Peng Liu, Hong Wei Pan, Wen-Juan Fan and Zheng-Yu Liu
    Citation: Journal of Translational Medicine 2022 20:361
  25. The current study aimed to construct a novel cancer artificial intelligence survival analysis system for predicting the individual mortality risk curves for cervical carcinoma patients receiving different trea...

    Authors: Jieyi Liang, Tingshan He, Hong Li, Xueqing Guo and Zhiqiao Zhang
    Citation: Journal of Translational Medicine 2022 20:293
  26. Sepsis is a life-threatening syndrome eliciting highly heterogeneous host responses. Current prognostic evaluation methods used in clinical practice are characterized by an inadequate effectiveness in predicti...

    Authors: Fei Guo, Xishun Zhu, Zhiheng Wu, Li Zhu, Jianhua Wu and Fan Zhang
    Citation: Journal of Translational Medicine 2022 20:265
  27. Previous studies demonstrated a positive relationship between birthweight and breast cancer; however, inconsistent, sometimes even controversial, observations also emerged, and the nature of such relationship ...

    Authors: Meng Zhang, Jiahao Qiao, Shuo Zhang and Ping Zeng
    Citation: Journal of Translational Medicine 2022 20:227
  28. While ondansetron (OND) is widespread availability, the contribution of OND to improve patient outcomes among intensive care unit (ICU) patients has not been examined. This study aimed to illustrate the associ...

    Authors: Yingying Fang, Chao Xiong and Xinghe Wang
    Citation: Journal of Translational Medicine 2022 20:223
  29. Acute kidney injury (AKI) is the most common and serious complication of sepsis, accompanied by high mortality and disease burden. The early prediction of AKI is critical for timely intervention and ultimately...

    Authors: Suru Yue, Shasha Li, Xueying Huang, Jie Liu, Xuefei Hou, Yumei Zhao, Dongdong Niu, Yufeng Wang, Wenkai Tan and Jiayuan Wu
    Citation: Journal of Translational Medicine 2022 20:215
  30. Oropharyngeal dysphagia (OD) refers to any abnormality in the physiology of swallowing in the upper gastrointestinal tract, which leads to the related clinical complications, such as malnutrition, dehydration,...

    Authors: Fatemeh Rajati, Nassim Ahmadi, Zahra Al-sadat Naghibzadeh and Mohsen Kazeminia
    Citation: Journal of Translational Medicine 2022 20:175
  31. Acute kidney injury (AKI) is a major complication following cardiac surgery that substantially increases morbidity and mortality. Current diagnostic guidelines based on elevated serum creatinine and/or the pre...

    Authors: Hang Zhang, Zhongtian Wang, Yingdan Tang, Xin Chen, Dongfang You, Yaqian Wu, Min Yu, Wen Chen, Yang Zhao and Xin Chen
    Citation: Journal of Translational Medicine 2022 20:166
  32. Established prediction models of Diabetic kidney disease (DKD) are limited to the analysis of clinical research data or general population data and do not consider hospital visits. Construct a 3-year diabetic ...

    Authors: Zheyi Dong, Qian Wang, Yujing Ke, Weiguang Zhang, Quan Hong, Chao Liu, Xiaomin Liu, Jian Yang, Yue Xi, Jinlong Shi, Li Zhang, Ying Zheng, Qiang Lv, Yong Wang, Jie Wu, Xuefeng Sun…
    Citation: Journal of Translational Medicine 2022 20:143
  33. Determining the risk of Cardiovascular Disease (CVD) is a necessity for timely preventive interventions in high-risk groups. However, laboratory testing may be impractical in countries with limited resources. ...

    Authors: Fatemeh Rezaei, Mozhgan Seif, Abdullah Gandomkar, Mohammad Reza Fattahi, Fatemeh Malekzadeh, Sadaf G. Sepanlou and Jafar Hasanzadeh
    Citation: Journal of Translational Medicine 2022 20:133
  34. Safety, tolerability and efficacy of granulocyte colony-stimulating factor (G-CSF) for mobilization of hematopoietic stem and progenitor cells (HSPCs) from healthy donors have been conclusively demonstrated. T...

    Authors: J. Heyn, S. Bräuninger, M. Dimova-Dobreva, N. Mathieson, N. Koptelova, A. Kolpakova, C. Seidl, P. Reinhardt, C. Tsamadou, H. Schrezenmeier, R. Nakov, E. Seifried and H. Bonig
    Citation: Journal of Translational Medicine 2022 20:121
  35. Frailty, determined by the Canadian Study of Health and Aging-Clinical Frailty Scale (CFS), is strongly associated with clinical outcomes including mortality in patients with COVID-19. However, the relationshi...

    Authors: Josh McGovern, Yassir Al-Azzawi, Olivia Kemp, Peter Moffitt, Conor Richards, Ross D. Dolan, Barry J. Laird, Donald C. McMillan and Donogh Maguire
    Citation: Journal of Translational Medicine 2022 20:98
  36. The number of elderly patients with early renal cell carcinoma (RCC) is on the rise. However, there is still a lack of accurate prediction models for the prognosis of early RCC in elderly patients. It is neces...

    Authors: Jinkui Wang, Jie Tang, Tiaoyao Chen, Song Yue, Wanting Fu, Zulong Xie and Xiaozhu Liu
    Citation: Journal of Translational Medicine 2022 20:90
  37. Epithelial–mesenchymal transition (EMT) is a dynamic and complex cellular process that is known to be hijacked by cancer cells to facilitate invasion, metastasis and therapeutic resistance. Several quantitativ...

    Authors: Ankit P. Jain, Janani Sambath, Gajanan Sathe, Irene A. George, Akhilesh Pandey, Erik W. Thompson and Prashant Kumar
    Citation: Journal of Translational Medicine 2022 20:84
  38. Chinese herbal medicine is made up of hundreds of natural drug molecules and has played a major role in traditional Chinese medicine (TCM) for several thousand years. Therefore, it is of great significance to ...

    Authors: Pengcheng Zhao, Lin Lin, Mozheng Wu, Lili Wang, Qi Geng, Li Li, Ning Zhao, Jianyu Shi and Cheng Lu
    Citation: Journal of Translational Medicine 2022 20:67
  39. Approximately 40% of persons with inflammatory bowel disease (IBD) experience psychiatric comorbidities (PC). Previous studies demonstrated the polygenetic effect on both IBD and PC. In this study, we evaluate...

    Authors: Yao Li, Charles N. Bernstein, Wei Xu and Pingzhao Hu
    Citation: Journal of Translational Medicine 2022 20:43
  40. A fraction of patients referred for complex molecular profiling of biopsied tumors may harbor germline variants in genes associated with the development of hereditary cancer syndromes (HCS). Neither the bioinf...

    Authors: Alexandra Lebedeva, Yulia Shaykhutdinova, Daria Seriak, Ekaterina Ignatova, Ekaterina Rozhavskaya, Divyasphoorthi Vardhan, Sofia Manicka, Margarita Sharova, Tatiana Grigoreva, Ancha Baranova, Vladislav Mileyko and Maxim Ivanov
    Citation: Journal of Translational Medicine 2022 20:29
  41. Sepsis is the leading cause of death in the intensive care unit (ICU). Expediting its diagnosis, largely determined by clinical assessment, improves survival. Predictive and explanatory modelling of sepsis in ...

    Authors: Holger A. Lindner, Shigehiko Schamoni, Thomas Kirschning, Corinna Worm, Bianka Hahn, Franz-Simon Centner, Jochen J. Schoettler, Michael Hagmann, Jörg Krebs, Dennis Mangold, Stephanie Nitsch, Stefan Riezler, Manfred Thiel and Verena Schneider-Lindner
    Citation: Journal of Translational Medicine 2022 20:27
  42. We aimed to compare cardiovascular risks among participants with T2DM with and without subsequent HTN and participants with HTN with and without subsequent T2DM.

    Authors: Fu-Shun Yen, James Cheng-Chung Wei, Lu-Ting Chiu, Chih-Cheng Hsu and Chii-Min Hwu
    Citation: Journal of Translational Medicine 2022 20:9
  43. People with liver disease are at increased risk of developing cardiovascular disease (CVD), however, there has yet been an investigation of incidence burden, risk, and premature mortality across a wide range o...

    Authors: Wai Hoong Chang, Stefanie H. Mueller, Sheng-Chia Chung, Graham R. Foster and Alvina G. Lai
    Citation: Journal of Translational Medicine 2022 20:2
  44. The current guidelines of the American Joint Committee on Cancer (AJCC) for the staging of exocrine pancreatic tumors seem inapplicable to malignant pancreatic intraductal papillary mucinous neoplasms (IPMN). ...

    Authors: Haoxiang Zhang, Chenggang Gao, Jiaoshun Chen, Shihong Wu, Jianwei Bai and Tao Yin
    Citation: Journal of Translational Medicine 2021 19:525
  45. Association between blood pressure (BP) and kidney function among the middle and old aged general population without hypertension remains unclear.

    Authors: Huai-yu Wang, Qinqin Meng, Chao Yang, Yafeng Wang, Guilan Kong, Yaohui Zhao, Fang Wang and Luxia Zhang
    Citation: Journal of Translational Medicine 2021 19:512
  46. Cancer is one of the most serious diseases threatening human health. Cancer immunotherapy represents the most promising treatment strategy due to its high efficacy and selectivity and lower side effects compar...

    Authors: Shihu Jiao, Quan Zou, Huannan Guo and Lei Shi
    Citation: Journal of Translational Medicine 2021 19:449
  47. High morbidity and mortality due to carbapenem-resistant Gram-negative bacilli (CR-GNB) has led to the resurgence of polymyxin B (PMB) use in the last decade. The aim of our multicenter, real-world study was t...

    Authors: Xiaojuan Zhang, Shaoyan Qi, Xiaoguang Duan, Bing Han, Shuguang Zhang, Shaohua Liu, Haixu Wang, Haibo Zhang and Tongwen Sun
    Citation: Journal of Translational Medicine 2021 19:431

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