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Molecular Pathology

Section edited by Sarah Warren

Molecular pathology has existed as a discipline for centuries, though without the modern name. Accumulating scientific insights, along with novel technological advances, are leading to greater understanding of the underlying causes of disease and novel diagnostic assays to inform clinical care. This section will serve as a platform to highlight studies that characterize human-derived biological materials, including both tissue and liquid biopsies, using molecular profiling techniques to elucidate the underlying causes of disease and impacts of therapeutic interventions. 

We expect the section to appeal to scientists working on transcriptomics, proteomics, lipidomics, glycomics and beyond. Furthermore, we anticipate most studies in this section will be preclinical or translational in nature, although we will consider works from all stages of fundamental and applied research. We also welcome manuscripts that describe new technology platforms that advance molecular profiling or novel computational approaches to support data analysis.

  1. Metastasis renal cell carcinoma (RCC) patients have extremely high mortality rate. A predictive model for RCC micrometastasis based on pathomics could be beneficial for clinicians to make treatment decisions.

    Authors: Feng Gao, Liren Jiang, Tuanjie Guo, Jun Lin, Weiqing Xu, Lin Yuan, Yaqin Han, Jiji Yang, Qi Pan, Enhui Chen, Ning Zhang, Siteng Chen and Xiang Wang
    Citation: Journal of Translational Medicine 2024 22:568
  2. In recent years, single-cell analyses have revealed the heterogeneity of the tumour microenvironment (TME) at the genomic, transcriptomic, and proteomic levels, further improving our understanding of the mecha...

    Authors: Jie Zhu, Ke Zhang, Yuan Chen, Xinyu Ge, Junqing Wu, Peng Xu and Jie Yao
    Citation: Journal of Translational Medicine 2024 22:563
  3. Cellular communication (CC) influences tumor development by mediating intercellular junctions between cells. However, the role and underlying mechanisms of CC in malignant transformation remain unknown. Here, ...

    Authors: Jie-pin Li, Yuan-jie Liu, Yang Li, Yi Yin, Qian-wen Ye, Zhi-hua Lu, Yu-wei Dong, Jin-yong Zhou, Xi Zou and Yu-gen Chen
    Citation: Journal of Translational Medicine 2024 22:549
  4. Inflammation and dysregulated immunity play vital roles in idiopathic pulmonary arterial hypertension (IPAH), while the mechanisms that initiate and promote these processes are unclear.

    Authors: Xincheng Li, Shuangshuang Ma, Qi Wang, Yishan Li, Xiaofan Ji, Jixiang Liu, Jing Ma, Yongbing Wang, Zhu Zhang, Hong Zhang, Hong Chen, Linfeng Xi, Yunxia Zhang, Wanmu Xie, Lu Sun, Zhihui Fu…
    Citation: Journal of Translational Medicine 2024 22:502
  5. The immune microenvironment impacts tumor growth, invasion, metastasis, and patient survival and may provide opportunities for therapeutic intervention in pancreatic ductal adenocarcinoma (PDAC). Although neve...

    Authors: Lyanne Delgado-Coka, Michael Horowitz, Mariana Torrente-Goncalves, Lucia Roa-Peña, Cindy V. Leiton, Mahmudul Hasan, Sruthi Babu, Danielle Fassler, Jaymie Oentoro, Ji-Dong K Bai, Emanuel F. Petricoin III, Lynn M. Matrisian, Edik Matthew Blais, Natalia Marchenko, Felicia D. Allard, Wei Jiang…
    Citation: Journal of Translational Medicine 2024 22:443
  6. Advanced unresectable gastric cancer (GC) patients were previously treated with chemotherapy alone as the first-line therapy. However, with the Food and Drug Administration’s (FDA) 2022 approval of programmed ...

    Authors: Yifan Liu, Wei Chen, Ruiwen Ruan, Zhimei Zhang, Zhixiong Wang, Tianpei Guan, Qi Lin, Wei Tang, Jun Deng, Zhao Wang and Guanghua Li
    Citation: Journal of Translational Medicine 2024 22:438
  7. Proliferative nodular formation represents a characteristic pathological feature of benign prostatic hyperplasia (BPH) and serves as the primary cause for prostate volume enlargement and consequent lower urina...

    Authors: Xiawei Fei, Jican Liu, Junyan Xu, Hongyan Jing, Zhonglin Cai, Jiasheng Yan, Zhenqi Wu, Huifeng Li, Zhong Wang and Yanting Shen
    Citation: Journal of Translational Medicine 2024 22:380
  8. The spatial localisation of immune cells within tumours are key to understand the intercellular communications that can dictate clinical outcomes. Here, we demonstrate an analysis pipeline for highly multiplex...

    Authors: James Monkman, Afshin Moradi, Joseph Yunis, Geoff Ivison, Aaron Mayer, Rahul Ladwa, Ken O’Byrne and Arutha Kulasinghe
    Citation: Journal of Translational Medicine 2024 22:239
  9. Clear cell renal cell carcinoma is a prototypical tumor characterized by metabolic reprogramming, which extends beyond tumor cells to encompass diverse cell types within the tumor microenvironment. Nonetheless...

    Authors: Guanwen Yang, Jiangting Cheng, Jiayi Xu, Chenyang Shen, Xuwei Lu, Chang He, Jiaqi Huang, Minke He, Jie Cheng and Hang Wang
    Citation: Journal of Translational Medicine 2024 22:210
  10. Immunotherapy has significantly improved survival of esophageal squamous cell cancer (ESCC) patients, however the clinical benefit was limited to only a small portion of patients. This study aimed to perform a...

    Authors: Butuo Li, Wenru Qin, Linlin Yang, Haoqian Li, Chao Jiang, Yueyuan Yao, Shuping Cheng, Bing Zou, Bingjie Fan, Taotao Dong and Linlin Wang
    Citation: Journal of Translational Medicine 2024 22:195
  11. Combined small-cell lung carcinoma (cSCLC) represents a rare subtype of SCLC, the mechanisms governing the evolution of cancer genomes and their impact on the tumor immune microenvironment (TIME) within distin...

    Authors: Wenjuan Ma, Ting Zhou, Mengmeng Song, Jiaqing Liu, Gang Chen, Jianhua Zhan, Liyan Ji, Fan Luo, Xuan Gao, Pansong Li, Xuefeng Xia, Yan Huang and Li Zhang
    Citation: Journal of Translational Medicine 2024 22:189
  12. The capability to gather heterogeneous data, alongside the increasing power of artificial intelligence to examine it, leading a revolution in harnessing multimodal data in the life sciences. However, most appr...

    Authors: Xiaobing Feng, Wen Shu, Mingya Li, Junyu Li, Junyao Xu and Min He
    Citation: Journal of Translational Medicine 2024 22:131