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Molecular Pathology

Section edited by Sarah Warren

Molecular pathology has existed as a discipline for centuries, though without the modern name. Accumulating scientific insights, along with novel technological advances, are leading to greater understanding of the underlying causes of disease and novel diagnostic assays to inform clinical care. This section will serve as a platform to highlight studies that characterize human-derived biological materials, including both tissue and liquid biopsies, using molecular profiling techniques to elucidate the underlying causes of disease and impacts of therapeutic interventions. 

We expect the section to appeal to scientists working on transcriptomics, proteomics, lipidomics, glycomics and beyond. Furthermore, we anticipate most studies in this section will be preclinical or translational in nature, although we will consider works from all stages of fundamental and applied research. We also welcome manuscripts that describe new technology platforms that advance molecular profiling or novel computational approaches to support data analysis.

  1. Clear cell renal cell carcinoma is a prototypical tumor characterized by metabolic reprogramming, which extends beyond tumor cells to encompass diverse cell types within the tumor microenvironment. Nonetheless...

    Authors: Guanwen Yang, Jiangting Cheng, Jiayi Xu, Chenyang Shen, Xuwei Lu, Chang He, Jiaqi Huang, Minke He, Jie Cheng and Hang Wang
    Citation: Journal of Translational Medicine 2024 22:210
  2. Immunotherapy has significantly improved survival of esophageal squamous cell cancer (ESCC) patients, however the clinical benefit was limited to only a small portion of patients. This study aimed to perform a...

    Authors: Butuo Li, Wenru Qin, Linlin Yang, Haoqian Li, Chao Jiang, Yueyuan Yao, Shuping Cheng, Bing Zou, Bingjie Fan, Taotao Dong and Linlin Wang
    Citation: Journal of Translational Medicine 2024 22:195
  3. Combined small-cell lung carcinoma (cSCLC) represents a rare subtype of SCLC, the mechanisms governing the evolution of cancer genomes and their impact on the tumor immune microenvironment (TIME) within distin...

    Authors: Wenjuan Ma, Ting Zhou, Mengmeng Song, Jiaqing Liu, Gang Chen, Jianhua Zhan, Liyan Ji, Fan Luo, Xuan Gao, Pansong Li, Xuefeng Xia, Yan Huang and Li Zhang
    Citation: Journal of Translational Medicine 2024 22:189
  4. The capability to gather heterogeneous data, alongside the increasing power of artificial intelligence to examine it, leading a revolution in harnessing multimodal data in the life sciences. However, most appr...

    Authors: Xiaobing Feng, Wen Shu, Mingya Li, Junyu Li, Junyao Xu and Min He
    Citation: Journal of Translational Medicine 2024 22:131