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Network Medicines

Section edited by Wendy Mao and Gianni Monaco

The Network Medicines section is dedicated to the biology-based, integrative approach aimed at understanding the topology of complex disorders and the dynamic interplay of their various components, identifying cascades of causes and effects, listening to cross-talks among cells to suggest novel and more effective therapeutic approaches.

The Network Medicines section aims to build disease atlases with the accuracy matching that of global positioning systems by providing a comprehensive framework of information collected from experimental and clinical data that can identify methods to resolve disease in the most efficient pathway. The section welcomes research that goes beyond descriptive observations and provides compelling recommendations of disruptive therapeutic candidates.

  1. Deciphering the role of plasma proteins in pancreatic cancer (PC) susceptibility can aid in identifying novel targets for diagnosis and treatment.

    Authors: Siyu Zhou, Baian Tao, Yujie Guo, Jichun Gu, Hengchao Li, Caifeng Zou, Sichong Tang, Shuheng Jiang, Deliang Fu and Ji Li
    Citation: Journal of Translational Medicine 2024 22:557
  2. Hepatocellular carcinoma (HCC) causes significant cancer mortality worldwide. Cancer organoids can serve as useful disease models by high costs, complexity, and contamination risks from animal-derived products...

    Authors: Azza M. El-Derby, Mennatallah A. Khedr, Nehal I. Ghoneim, Mahmoud M. Gabr, Sherry M. Khater and Nagwa El-Badri
    Citation: Journal of Translational Medicine 2024 22:487
  3. Extracellular vesicles (EVs) are lipid bilayer structures released by all cells and widely distributed in all biological fluids. EVs are implicated in diverse physiopathological processes by orchestrating cell...

    Authors: Soheil Rahmati, Aysan Moeinafshar and Nima Rezaei
    Citation: Journal of Translational Medicine 2024 22:452
  4. Current cancer therapies often fall short in addressing the complexities of malignancies, underscoring the urgent need for innovative treatment strategies. RNA interference technology, which specifically suppr...

    Authors: Junxiao Chen, Ziyuan Liu, Haiting Fang, Qing Su, Yiqi Fan, Luyao Song and Shuai He
    Citation: Journal of Translational Medicine 2024 22:395
  5. Pancreatic ductal adenocarcinoma (PDAC) is a lethal malignancy with high probability of recurrence and distant metastasis. Liver metastasis is the predominant metastatic mode developed in most pancreatic cance...

    Authors: Xiaohong Liu, Bo Ren, Yuan Fang, Jie Ren, Xing Wang, Minzhi Gu, Feihan Zhou, Ruiling Xiao, Xiyuan Luo, Lei You and Yupei Zhao
    Citation: Journal of Translational Medicine 2024 22:393
  6. Inflammatory breast cancer (IBC) is the most pro-metastatic form of BC. Better understanding of its enigmatic pathophysiology is crucial. We report here the largest whole-exome sequencing (WES) study of clinic...

    Authors: François Bertucci, Florence Lerebours, Michele Ceccarelli, Arnaud Guille, Najeeb Syed, Pascal Finetti, José Adélaïde, Steven Van Laere, Anthony Goncalves, Patrice Viens, Daniel Birnbaum, Emilie Mamessier, Céline Callens and Davide Bedognetti
    Citation: Journal of Translational Medicine 2024 22:374
  7. Platelets not only participate in thrombosis and hemostasis but also interact with tumor cells and protect them from mechanical damage caused by hemodynamic shear stress and natural killer cell lysis, thereby ...

    Authors: Jie Xue, Jianzhao Deng, Hongwei Qin, Songxia Yan, Zhen Zhao, Lifeng Qin, Jiao Liu and Haiyan Wang
    Citation: Journal of Translational Medicine 2024 22:371
  8. Chemoimmunotherapy has shown promising advantages of eliciting immunogenic cell death and activating anti-tumor immune responses. However, the systemic toxicity of chemotherapy and tumor immunosuppressive micr...

    Authors: Qin Liu, Rui Xu, Jingwen Shen, Yaping Tao, Jingyi Shao, Yaohua Ke and Baorui Liu
    Citation: Journal of Translational Medicine 2024 22:341
  9. Regulatory T cells (Tregs) expressing the transcription factor FoxP3 are essential for maintaining immunological balance and are a significant component of the immunosuppressive tumor microenvironment (TME). S...

    Authors: Yu Li, Cangang Zhang, Aimin Jiang, Anqi Lin, Zaoqu Liu, Xiangshu Cheng, Wanting Wang, Quan Cheng, Jian Zhang, Ting Wei and Peng Luo
    Citation: Journal of Translational Medicine 2024 22:293
  10. Osteoarthritis (OA) is a multifactorial, hypertrophic, and degenerative condition involving the whole joint and affecting a high percentage of middle-aged people. It is due to a combination of factors, althoug...

    Authors: Maria Claudia Costa, Claudia Angelini, Monica Franzese, Concetta Iside, Marco Salvatore, Luigi Laezza, Francesco Napolitano and Michele Ceccarelli
    Citation: Journal of Translational Medicine 2024 22:281
  11. Most anti-cancer modalities are designed to directly kill cancer cells deploying mechanisms of action (MOAs) centered on the presence of a precise target on cancer cells. The efficacy of these approaches is li...

    Authors: Joyce Hu, Paolo Ascierto, Alessandra Cesano, Volker Herrmann and Francesco M. Marincola
    Citation: Journal of Translational Medicine 2024 22:270
  12. Predictive biomarkers of immune checkpoint inhibitor (ICI) efficacy are currently lacking for non-small cell lung cancer (NSCLC). Here, we describe the results from the Anti–PD-1 Response Prediction DREAM Chal...

    Authors: Mike Mason, Óscar Lapuente-Santana, Anni S. Halkola, Wenyu Wang, Raghvendra Mall, Xu Xiao, Jacob Kaufman, Jingxin Fu, Jacob Pfeil, Jineta Banerjee, Verena Chung, Han Chang, Scott D. Chasalow, Hung Ying Lin, Rongrong Chai, Thomas Yu…
    Citation: Journal of Translational Medicine 2024 22:190
  13. Patients with pancreatic ductal adenocarcinoma (PDCA) carrying impaired mismatch repair mechanisms seem to have an outcome advantage under treatment with conventional chemotherapy, whereas the role for the tum...

    Authors: Maria Cristina Sini, Maria Grazia Doro, Laura Frogheri, Angelo Zinellu, Panagiotis Paliogiannis, Alberto Porcu, Fabrizio Scognamillo, Daniele Delogu, Davide Adriano Santeufemia, Ivana Persico, Grazia Palomba, Giovanni Battista Maestrale, Antonio Cossu and Giuseppe Palmieri
    Citation: Journal of Translational Medicine 2024 22:108
  14. Atopic dermatitis (AD) is a prevalent chronic inflammatory skin disease whose pathophysiology involves the interplay between genetic and environmental factors, ultimately leading to dysfunction of the epidermi...

    Authors: Antonio Federico, Lena Möbus, Zeyad Al-Abdulraheem, Alisa Pavel, Vittorio Fortino, Giusy del Giudice, Harri Alenius, Nanna Fyhrquist and Dario Greco
    Citation: Journal of Translational Medicine 2024 22:64