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Reproductive Medicine & Clinical Reproductive Sciences

Section edited by Matteo Alessandro Avella

© Sebastian Kaulitzki / stock.adobe.comReproductive medicine is a fast-moving field whose ultimate goal is to provide people with better reproductive choices. This section aims to provide a platform for new research focusing on the basic mechanisms or the translational and clinical aspects of human reproductive biology.

The section encourages submissions of preclinical and clinical studies whose results have the potential to prevent, diagnose, and treat reproductive issues, as well as studies that describe and characterize the genes and the mechanisms regulating human reproductive biology in cell line or animal models. The section also welcomes reviews on existing and novel technologies, and commentaries on scientific breakthroughs in the field. 

  1. Miscarriage is a frustrating complication of pregnancy that is common among women of reproductive age. Insufficient decidualization which not only impairs embryo implantation but disturbs fetomaternal immune-t...

    Authors: Jie Zhang, Mingxing Xue, Jiefang Huang, Shan He, Lingqiao Zhu, Xiaonan Zhao, Bei Wang, Tingwang Jiang, Yanyun Zhang, Changhong Miao and Guoqiang Zhou
    Citation: Journal of Translational Medicine 2024 22:478
  2. The study of the functional genome in mice and humans has been instrumental for describing the conserved molecular mechanisms regulating human reproductive biology, and for defining the etiologies of monogenic...

    Authors: Khalid A. Fakhro, Johnny Awwad, Suma Garibova, Luis R. Saraiva and Matteo Avella
    Citation: Journal of Translational Medicine 2024 22:473
  3. Polycystic ovary syndrome (PCOS) is an endocrinological and metabolic disorder that can lead to female infertility. Lipid metabolomics and proteomics are the new disciplines in systems biology aimed to discove...

    Authors: Yu Qian, Yun Tong, Yaqiong Zeng, Jingyu Huang, Kailu Liu, Ying Xie, Juan Chen, Mengya Gao, Li Liu, Juan Zhao, Yanli Hong and Xiaowei Nie
    Citation: Journal of Translational Medicine 2024 22:364
  4. Neural Tube Defects (NTDs) are congenital malformations of the central nervous system resulting from the incomplete closure of the neural tube during early embryonic development. Neuroinflammation refers to th...

    Authors: Wenshuang Wang, Yanhong Ji, Zhexu Dong, Zheran Liu, Shuang Chen, Lei Dai, Xiaolan Su, Qingyuan Jiang and Hongxin Deng
    Citation: Journal of Translational Medicine 2024 22:257
  5. Macrophages phenotypic deviation and immune imbalance play vital roles in pregnancy-associated diseases such as spontaneous miscarriage. Trophoblasts regulate phenotypic changes in macrophages, however, their ...

    Authors: Jing Yang, Longfei Li, Linlin Wang, Ruizhi Chen, Xiaobing Yang, Juanhua Wu, Gang Feng, Jinli Ding, Lianghui Diao, Jiao Chen and Jing Yang
    Citation: Journal of Translational Medicine 2024 22:19
  6. Congenital heart defect (CHD) is the most common congenital abnormality, and it has long been a clinical and public health concern. Our previous findings have found Periostin (POSTN) and Pappalysin-1 (PAPPA) a...

    Authors: Yi Xia, Liang Chen, JinWen Lu, Jianhong Ma and Yuanzhen Zhang
    Citation: Journal of Translational Medicine 2023 21:901
  7. The testis is a complex organ that undergoes extensive developmental changes from the embryonic stage to adulthood. The development of germ cells, which give rise to spermatozoa, is tightly regulated by the su...

    Authors: Najmeh Salehi and Mehdi Totonchi
    Citation: Journal of Translational Medicine 2023 21:859
  8. CRISPR/Cas9, a highly versatile genome-editing tool, has garnered significant attention in recent years. Despite the unique characteristics of oocytes and early embryos compared to other cell types, this techn...

    Authors: Yi-ran Zhang, Tai-lang Yin and Li-quan Zhou
    Citation: Journal of Translational Medicine 2023 21:746
  9. Preeclampsia (PE) is a leading cause of maternal and perinatal mortality and morbidity worldwide, but effective early prediction remains a challenge due to the lack of reliable biomarkers.

    Authors: Mingxi Liu, Yue Niu, Kongyang Ma, Peter C. K. Leung, Zi-Jiang Chen, Daimin Wei and Yan Li
    Citation: Journal of Translational Medicine 2023 21:634
  10. Preeclampsia is a common pregnancy complication characterized by high blood pressure and damage to organs. Abnormal placenta and vascular function can lead to preeclampsia. Accumulating evidence has suggested ...

    Authors: Jizi Zhou, Ying Zhao, Ping An, Huanqiang Zhao, Xiaotian Li and Yu Xiong
    Citation: Journal of Translational Medicine 2023 21:509
  11. Substantial studies have demonstrated that oxidative stress placenta and endothelial injury are considered to inextricably critical events in the pathogenesis of preeclampsia (PE). Systemic inflammatory respon...

    Authors: Qian Chen, Jiexing He, Haihua Liu, Qiuyu Huang, Shuoshi Wang, Ailan Yin, Shuying Chen, Xinyang Shen, Yanxuan Xiao, Haoyue Hu, Jiayi Jiang, Wenqian Chen, Song Wang, Zhenqin Huang, Jiaqi Li, You Peng…
    Citation: Journal of Translational Medicine 2023 21:496
  12. The global delay in women’s reproductive age has raised concerns about age-related infertility. The decline in oocyte quality is a limiting factor of female fertility, yet there are currently no strategies to ...

    Authors: Yun-Yao Luo, Xi Zeng, Ling Zhu, Chong Li, Juan Xie, Qiang Dong, Qing-Yuan Sun, Guo-Ning Huang and Jing-Yu Li
    Citation: Journal of Translational Medicine 2023 21:426
  13. Endometriosis (EMs), the ectopic planting of functional endometrium outside of the uterus, is a leading cause of infertility and pelvic pain. As a fundamental mRNA modification, N6-methyladenosine (m6A) partic...

    Authors: Xiaotong Wang, Jing Wang, Xibo Zhao, Han Wu, Jixin Li, Yan Cheng, Qiuyan Guo, Xuejiao Cao, Tian Liang, Liyuan Sun and Guangmei Zhang
    Citation: Journal of Translational Medicine 2023 21:407
  14. Docosahexaenoic acid (DHA) supplementation is recommended for women during pregnancy because of its neurological, visual, and cognitive effects. Previous studies have suggested that DHA supplementation during ...

    Authors: Yi Jiang, Yuting Chen, Lijie Wei, Huiting Zhang, Jingyi Zhang, Xuan Zhou, Shenglan Zhu, Yuanyuan Du, Rui Su, Chenyun Fang, Wencheng Ding and Ling Feng
    Citation: Journal of Translational Medicine 2023 21:394
  15. Polycystic ovary syndrome (PCOS) is a metabolic-reproductive-endocrine disorder that, while having a genetic component, is known to have a complex multifactorial etiology. As PCOS is a diagnosis of exclusion, ...

    Authors: Sania Shabbir, Emaan Khurram, Vedhika Sathya Moorthi, Youssef Tamer Hassan Eissa, Mohammad Azhar Kamal and Alexandra E. Butler
    Citation: Journal of Translational Medicine 2023 21:259