Immunobiology and immunotherapy

Section edited by Adrian Bot

This section aims to enrich the communication between basic biological and immunological sciences and the clinical investigation arena.

As immunology has evolved to be a central discipline connected to a wide range of therapeutic areas, the number and diversity of platform technologies has also increased, spanning small molecules, biologics, microbial vectors and cells. Such levels of activity require appropriate means to share new knowledge and to catalyze the development of the field. This section aims to provide such a platform and welcomes submissions across all disciplines, including inflammation, autoimmunity, transplantation, metabolic disorders.

The section was founded with the Society for Immunotherapy of Cancer (SITC) under the title "Tumor immunology and biological cancer therapy" and Edited by Pedro Romero.

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  1. Research

    Understanding immune phenotypes in human gastric disease tissues by multiplexed immunohistochemistry

    Understanding immune phenotypes and human gastric disease in situ requires an approach that leverages multiplexed immunohistochemistry (mIHC) with multispectral imaging to facilitate precise image analyses.

    Le Ying, Feng Yan, Qiaohong Meng, Xiangliang Yuan, Liang Yu, Bryan R. G. Williams, David W. Chan, Liyun Shi, Yugang Tu, Peihua Ni, Xuefeng Wang, Dakang Xu and Yiqun Hu

    Journal of Translational Medicine 2017 15:206

    Published on: 12 October 2017

  2. Meeting report

    Perspectives in immunotherapy: meeting report from the “Immunotherapy Bridge”, Napoli, November 30th 2016

    The complex interactions between the immune system and tumors lead the identification of key molecules that govern these interactions: immunotherapeutics were designed to overcome the mechanisms broken by tumo...

    Paolo A. Ascierto, Bruno Daniele, Hans Hammers, Vera Hirsh, Joseph Kim, Lisa Licitra, Rita Nanda and Sandro Pignata

    Journal of Translational Medicine 2017 15:205

    Published on: 11 October 2017

  3. Research

    A lipidated peptide of Mycobacterium tuberculosis resuscitates the protective efficacy of BCG vaccine by evoking memory T cell immunity

    The current BCG vaccine induces only short-term protection against Mycobacterium tuberculosis (Mtb), suggesting its failure to generate long-lasting memory T cells. Previously, we have demonstrated that a self-ad...

    Pradeep K. Rai, Sathi Babu Chodisetti, Weiguang Zeng, Sajid Nadeem, Sudeep K. Maurya, Susanta Pahari, Ashok K. Janmeja, David C. Jackson and Javed N. Agrewala

    Journal of Translational Medicine 2017 15:201

    Published on: 6 October 2017

  4. Research

    Transcriptomic meta-analysis identifies gene expression characteristics in various samples of HIV-infected patients with nonprogressive disease

    A small proportion of HIV-infected patients remain clinically and/or immunologically stable for years, including elite controllers (ECs) who have undetectable viremia (<50 copies/ml) and long-term nonprogresso...

    Le-Le Zhang, Zi-Ning Zhang, Xian Wu, Yong-Jun Jiang, Ya-Jing Fu and Hong Shang

    Journal of Translational Medicine 2017 15:191

    Published on: 12 September 2017

  5. Research

    Vaccine-draining lymph nodes of cancer patients for generating anti-cancer antibodies

    Our research is focused on using the vaccine draining lymph node to better understand the immune response to cancer vaccines and as a possible source of anti-cancer reagents. We evaluated vaccine draining lymp...

    Girja S. Shukla, Walter C. Olson, Stephanie C. Pero, Yu-jing Sun, Chelsea L. Carman, Craig L. Slingluff Jr. and David N. Krag

    Journal of Translational Medicine 2017 15:180

    Published on: 29 August 2017

  6. Review

    CSPG4: a prototype oncoantigen for translational immunotherapy studies

    Thanks to striking progress in both the understanding of anti-tumor immune response and the characterization of several tumor associated antigens (TAA), a more rational design and more sophisticated strategies...

    Valeria Rolih, Giuseppina Barutello, Selina Iussich, Raffaella De Maria, Elena Quaglino, Paolo Buracco, Federica Cavallo and Federica Riccardo

    Journal of Translational Medicine 2017 15:151

    Published on: 1 July 2017

  7. Review

    State of play and clinical prospects of antibody gene transfer

    Recombinant monoclonal antibodies (mAbs) are one of today’s most successful therapeutic classes in inflammatory diseases and oncology. A wider accessibility and implementation, however, is hampered by the high...

    Kevin Hollevoet and Paul J. Declerck

    Journal of Translational Medicine 2017 15:131

    Published on: 7 June 2017

  8. Research

    Dendritic cells combined with tumor cells and α-galactosylceramide induce a potent, therapeutic and NK-cell dependent antitumor immunity in B cell lymphoma

    Invariant natural killer T (iNKT) cells are a small population of lymphocytes with unique specificity for glycolipid antigens presented by non-polymorphic CD1d receptor on dendritic cells (DCs). iNKT cells pla...

    Laura Escribà-Garcia, Carmen Alvarez-Fernández, Marta Tellez-Gabriel, Jorge Sierra and Javier Briones

    Journal of Translational Medicine 2017 15:115

    Published on: 26 May 2017

  9. Review

    The spleen in liver cirrhosis: revisiting an old enemy with novel targets

    The spleen is a secondary lymphoid organ which can influence the progression of multiple diseases, notably liver cirrhosis. In chronic liver diseases, splenomegaly and hypersplenism can manifest following the ...

    Liang Li, Mubing Duan, Weisan Chen, An Jiang, Xiaoming Li, Jun Yang and Zongfang Li

    Journal of Translational Medicine 2017 15:111

    Published on: 23 May 2017

  10. Research

    A phase II trial of autologous dendritic cell vaccination and radiochemotherapy following fluorescence-guided surgery in newly diagnosed glioblastoma patients

    Prognosis of patients with glioblastoma multiforme (GBM) remains dismal, with median overall survival (OS) of about 15 months. It is therefore crucial to search alternative strategies that improve these result...

    Susana Inogés, Sonia Tejada, Ascensión López-Díaz de Cerio, Jaime Gállego Pérez-Larraya, Jaime Espinós, Miguel Angel Idoate, Pablo Daniel Domínguez, Reyes García de Eulate, Javier Aristu, Maurizio Bendandi, Fernando Pastor, Marta Alonso, Enrique Andreu, Felipe Prósper Cardoso and Ricardo Díez Valle

    Journal of Translational Medicine 2017 15:104

    Published on: 12 May 2017

  11. Research

    Whole blood gene expression in adolescent chronic fatigue syndrome: an exploratory cross-sectional study suggesting altered B cell differentiation and survival

    Chronic fatigue syndrome (CFS) is a prevalent and disabling condition affecting adolescents. The pathophysiology is poorly understood, but immune alterations might be an important component. This study compare...

    Chinh Bkrong Nguyen, Lene Alsøe, Jessica M. Lindvall, Dag Sulheim, Even Fagermoen, Anette Winger, Mari Kaarbø, Hilde Nilsen and Vegard Bruun Wyller

    Journal of Translational Medicine 2017 15:102

    Published on: 11 May 2017

  12. Review

    Anti-inflammatory effects of H2S during acute bacterial infection: a review

    Hydrogen sulfide (H2S), previously only considered a toxic environmental air pollutant, is now increasingly recognized as an important signaling molecule able to modulate several cellular pathways in many human t...

    Francesca Benedetti, Sabrina Curreli, Selvi Krishnan, Sergio Davinelli, Fiorenza Cocchi, Giovanni Scapagnini, Robert C. Gallo and Davide Zella

    Journal of Translational Medicine 2017 15:100

    Published on: 10 May 2017

  13. Research

    Adenovirus-mediated CD40L gene transfer increases Teffector/Tregulatory cell ratio and upregulates death receptors in metastatic melanoma patients

    Malignant melanoma is an aggressive tumor sensitive for immunotherapy such as checkpoint blockade antibodies. Still, most patients with late stage disease do not respond, and the side effects can be severe. St...

    A. Schiza, J. Wenthe, S. Mangsbo, E. Eriksson, Anders Nilsson, T. H. Tötterman, A. Loskog and G. Ullenhag

    Journal of Translational Medicine 2017 15:79

    Published on: 20 April 2017

  14. Research

    Levels of hepatic Th17 cells and regulatory T cells upregulated by hepatic stellate cells in advanced HBV-related liver fibrosis

    Liver fibrosis which mainly occurs upon chronic hepatitis virus infection potentially leads to portal hypertension, hepatic failure and hepatocellular carcinoma. However, the immune status of Th17 and Treg cel...

    Xiaoyan Li, Yujie Su, Xuefeng Hua, Chan Xie, Jing Liu, Yuehua Huang, Liang Zhou, Min Zhang, Xu Li and Zhiliang Gao

    Journal of Translational Medicine 2017 15:75

    Published on: 11 April 2017

  15. Research

    Proteomic analysis of protein purified derivative of Mycobacterium bovis

    Tuberculin skin test based on in vivo intradermal inoculation of purified protein derivative from Mycobacterium bovis (bPPD) is the diagnostic test for the control and surveillance of bovine tuberculosis (bTB).

    Sante Roperto, Mariaconcetta Varano, Valeria Russo, Roberta Lucà, Monica Cagiola, Marco Gaspari, Dora Maria Ceccarelli, Giovanni Cuda and Franco Roperto

    Journal of Translational Medicine 2017 15:68

    Published on: 3 April 2017

  16. Research

    TCD4pos lymphocytosis in rheumatoid and psoriatic arthritis patients following TNFα blocking agents

    Lymphocyte expansion and true lymphocytosis are commonly observed in the everyday clinical practice. The meaning of such phenomenon is often poorly understood so that discrimination between benign and malignan...

    Andrea Picchianti Diamanti, Bruno Laganà, Maria Christina Cox, Emanuela Pilozzi, Rachele Amodeo, Maurizio Bove, Milica Markovic, Roberta Di Rosa, Simonetta Salemi, Maria Laura Sorgi, Maria Manuela Rosado and Raffaele D’Amelio

    Journal of Translational Medicine 2017 15:38

    Published on: 21 February 2017

  17. Review

    Immune modulation of some autoimmune diseases: the critical role of macrophages and neutrophils in the innate and adaptive immunity

    Macrophages and neutrophils are key components involved in the regulation of numerous chronic inflammatory diseases, infectious disorders, and especially certain autoimmune disease. However, little is known re...

    Kely Campos Navegantes, Rafaelli de Souza Gomes, Priscilla Aparecida Tártari Pereira, Paula Giselle Czaikoski, Carolina Heitmann Mares Azevedo and Marta Chagas Monteiro

    Journal of Translational Medicine 2017 15:36

    Published on: 15 February 2017

  18. Research

    The active metabolite of leflunomide, A77 1726, attenuates inflammatory arthritis in mice with spontaneous arthritis via induction of heme oxygenase-1

    Leflunomide is a low-molecular-weight compound that is widely used in the treatment of rheumatoid arthritis. Although leflunomide is thought to act through the inhibition of the de novo pyrimidine synthesis, t...

    Su-Jin Moon, Eun-Kyung Kim, Joo Yeon Jhun, Hee Jin Lee, Weon Sun Lee, Sang-Hi Park, Mi-La Cho and Jun-Ki Min

    Journal of Translational Medicine 2017 15:31

    Published on: 13 February 2017

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