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Immunobiology and immunotherapy

Section edited by Alessandra Cesano

This section aims to enrich the communication between basic biological and immunological sciences and the clinical investigation arena.

As immunology has evolved to be a central discipline connected to a wide range of therapeutic areas, the number and diversity of platform technologies has also increased, spanning small molecules, biologics, microbial vectors and cells. Such levels of activity require appropriate means to share new knowledge and to catalyze the development of the field. This section aims to provide such a platform and welcomes submissions across all disciplines, including inflammation, autoimmunity, transplantation, metabolic disorders.

The section was founded with the Society for Immunotherapy of Cancer (SITC) under the title "Tumor immunology and biological cancer therapy" and Edited by Pedro Romero.

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  1. Content type: Methodology

    Interest in single-cell transcriptomic analysis is growing rapidly, especially for profiling rare or heterogeneous populations of cells. In almost all reported works investigators have used live cells, which i...

    Authors: Jinguo Chen, Foo Cheung, Rongye Shi, Huizhi Zhou and Wenrui Lu

    Citation: Journal of Translational Medicine 2018 16:198

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  2. Content type: Research

    The TGFβ-signaling pathway plays an important role in the pathogenesis of colorectal cancer (CRC). Loss of function of several genes within this pathway, such as bone morphogenetic proteins (BMPs) have been se...

    Authors: Andrew J. Pellatt, Lila E. Mullany, Jennifer S. Herrick, Lori C. Sakoda, Roger K. Wolff, Wade S. Samowitz and Martha L. Slattery

    Citation: Journal of Translational Medicine 2018 16:191

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  3. Content type: Research

    Standard therapy for glioblastoma includes surgery, radiotherapy, and temozolomide. This Phase 3 trial evaluates the addition of an autologous tumor lysate-pulsed dendritic cell vaccine (DCVax®-L) to standard the...

    Authors: Linda M. Liau, Keyoumars Ashkan, David D. Tran, Jian L. Campian, John E. Trusheim, Charles S. Cobbs, Jason A. Heth, Michael Salacz, Sarah Taylor, Stacy D. D’Andre, Fabio M. Iwamoto, Edward J. Dropcho, Yaron A. Moshel, Kevin A. Walter, Clement P. Pillainayagam, Robert Aiken…

    Citation: Journal of Translational Medicine 2018 16:142

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    The Correction to this article has been published in Journal of Translational Medicine 2018 16:179

  4. Content type: Research

    Ipilimumab is a licensed immunotherapy for metastatic melanoma patients and, in the US, as adjuvant treatment for high risk melanoma radically resected. The use of ipilimumab is associated with a typical but u...

    Authors: Sara Valpione, Sandro Pasquali, Luca Giovanni Campana, Luisa Piccin, Simone Mocellin, Jacopo Pigozzo and Vanna Chiarion-Sileni

    Citation: Journal of Translational Medicine 2018 16:94

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  5. Content type: Research

    “Avoiding immune destruction” has recently been established as one of the hallmarks of cancer. The programmed cell death (PD)-1/programmed cell death-ligand (PD-L) 1 pathway is an important immunosuppression m...

    Authors: Yuka Asano, Shinichiro Kashiwagi, Wataru Goto, Koji Takada, Katsuyuki Takahashi, Tamami Morisaki, Hisakazu Fujita, Tsutomu Takashima, Shuhei Tomita, Masahiko Ohsawa, Kosei Hirakawa and Masaichi Ohira

    Citation: Journal of Translational Medicine 2018 16:87

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  6. Content type: Research

    The aim of this study was to investigate the mechanisms of OX40L in regulating helper T (Th) cells differentiation through phosphoinositide 3-kinase (PI3K)/AKT and p38 mitogen-activated protein kinase signalin...

    Authors: Li Huang, Meijuan Wang, Yongdong Yan, Wenjing Gu, Xinxing Zhang, Jiahong Tan, Huiming Sun, Wei Ji and Zhengrong Chen

    Citation: Journal of Translational Medicine 2018 16:74

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  7. Content type: Research

    Fibrinogen is a central player in the blood coagulation cascade and one of the most abundant plasma proteins. This glycoprotein also triggers important events (e.g., cell spreading, the respiratory burst and d...

    Authors: Tiziana Alberio, Greta Forlani, Marta Lualdi, Giovanna Tosi, Roberto S. Accolla and Mauro Fasano

    Citation: Journal of Translational Medicine 2018 16:64

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  8. Content type: Research

    Shigellosis persists as a public health problem worldwide causing ~ 165,000 deaths every year, of which ~ 55,000 are in children less than 5 years of age. No vaccine against shigellosis is currently licensed. ...

    Authors: Franklin R. Toapanta, Paula J. Bernal, Karen L. Kotloff, Myron M. Levine and Marcelo B. Sztein

    Citation: Journal of Translational Medicine 2018 16:61

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  9. Content type: Research

    Th17 cells and its effective cytokine IL-17A play an important role in the pathogenesis of abnormal immune responses in psoriasis. Notch1 signaling has been implicated in Th17 cell differentiation and function...

    Authors: Lei Ma, Haibo Xue, Ruiqun Qi, Yanqin Wang and Libing Yuan

    Citation: Journal of Translational Medicine 2018 16:59

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  10. Content type: Research

    An altered gut microbiota balance is involved in the pathogenesis of inflammatory bowel disease (IBD), and several probiotic strains are used as dietary supplements to improve intestinal health. We evaluated t...

    Authors: Jin-Sil Park, JeongWon Choi, Ji Ye Kwon, Kyung-Ah Jung, Chul Woo Yang, Sung-Hwan Park and Mi-La Cho

    Citation: Journal of Translational Medicine 2018 16:37

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  11. Content type: Research

    During infection with human cytomegalovirus (HCMV) several viral proteins occur on cell surfaces in high quantity. We thus pursue an HLA-independent approach for immunotherapy of HCMV using chimeric antigen re...

    Authors: Julia Proff, Charlotte U. Brey, Armin Ensser, Wolfgang Holter and Manfred Lehner

    Citation: Journal of Translational Medicine 2018 16:26

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  12. Content type: Research

    Cancer vaccines can effectively establish clinically relevant tumor immunity. Novel sequencing approaches rapidly identify the mutational fingerprint of tumors, thus allowing to generate personalized tumor vac...

    Authors: Katja Sonntag, Hisayoshi Hashimoto, Matthias Eyrich, Moritz Menzel, Max Schubach, Dennis Döcker, Florian Battke, Carolina Courage, Helmut Lambertz, Rupert Handgretinger, Saskia Biskup and Karin Schilbach

    Citation: Journal of Translational Medicine 2018 16:23

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  13. Content type: Review

    Myeloid-derived suppressor cells (MDSCs) are a series of innate cells that play a significant role in inhibiting T cell-related responses. This heterogeneous population of immature cells is involved in tumor i...

    Authors: Weitao Zhang, Jiawei Li, Guisheng Qi, Guowei Tu, Cheng Yang and Ming Xu

    Citation: Journal of Translational Medicine 2018 16:19

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  14. Content type: Research

    There is a pressing need in rheumatoid arthritis (RA) to identify patients who will not respond to first-line disease-modifying anti-rheumatic drugs (DMARD). We explored whether differences in genomic architec...

    Authors: Claudio Carini, Ewan Hunter, Aroul S. Ramadass, Jayne Green, Alexandre Akoulitchev, Iain B. McInnes and Carl S. Goodyear

    Citation: Journal of Translational Medicine 2018 16:18

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  15. Content type: Research

    Genetic engineering of T-cells to express specific T cell receptors (TCR) has emerged as a novel strategy to treat various malignancies. More widespread utilization of these types of therapies has been somewha...

    Authors: Jianjian Jin, Nikolaos Gkitsas, Vicki S. Fellowes, Jiaqiang Ren, Steven A. Feldman, Christian S. Hinrichs, David F. Stroncek and Steven L. Highfill

    Citation: Journal of Translational Medicine 2018 16:13

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  16. Content type: Review

    γδ T cells are a distinct subgroup of T cells containing T cell receptors (TCRs) γ and TCR δ chains with diverse structural and functional heterogeneity. As a bridge between the innate and adaptive immune syst...

    Authors: Yijing Zhao, Chao Niu and Jiuwei Cui

    Citation: Journal of Translational Medicine 2018 16:3

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    The Correction to this article has been published in Journal of Translational Medicine 2018 16:122

  17. Content type: Research

    Cytokine disturbances have been suggested to be associated with the Chronic Fatigue Syndrome/Myalgic encephalomyelitis (CFS/ME) for decades.

    Authors: Megan E. Roerink, Hans Knoop, Ewald M. Bronkhorst, Henk A. Mouthaan, Luuk J. A. C. Hawinkels, Leo A. B. Joosten and Jos W. M. van der Meer

    Citation: Journal of Translational Medicine 2017 15:267

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  18. Content type: Research

    Ulcerative colitis (UC) is a highly progressive inflammatory disease that requires the interaction of epithelial, immune, endothelial and muscle cells and fibroblasts. Previous studies suggested two inflammato...

    Authors: Henrika Jodeleit, Pia Palamides, Florian Beigel, Thomas Mueller, Eckhard Wolf, Matthias Siebeck and Roswitha Gropp

    Citation: Journal of Translational Medicine 2017 15:265

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  19. Content type: Research

    Chronic fatigue syndrome (CFS) is a prevalent and disabling condition among adolescent. The disease mechanisms are unknown. Previous studies have suggested elevated plasma levels of several cytokines, but a re...

    Authors: Vegard Bruun Wyller, Chinh Bkrong Nguyen, Judith Anita Ludviksen and Tom Eirik Mollnes

    Citation: Journal of Translational Medicine 2017 15:245

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  20. Content type: Research

    Nivolumab is an anti-PD1 checkpoint inhibitor active in patients with advanced melanoma and as adjuvant therapy in high-risk metastatic melanoma patients.

    Authors: Silvana Morello, Mariaelena Capone, Claudia Sorrentino, Diana Giannarelli, Gabriele Madonna, Domenico Mallardo, Antonio M. Grimaldi, Aldo Pinto and Paolo Antonio Ascierto

    Citation: Journal of Translational Medicine 2017 15:244

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