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Immunobiology and immunotherapy

Section edited by Alessandra Cesano

This section aims to enrich the communication between basic biological and immunological sciences and the clinical investigation arena.

As immunology has evolved to be a central discipline connected to a wide range of therapeutic areas, the number and diversity of platform technologies has also increased, spanning small molecules, biologics, microbial vectors and cells. Such levels of activity require appropriate means to share new knowledge and to catalyze the development of the field. This section aims to provide such a platform and welcomes submissions across all disciplines, including inflammation, autoimmunity, transplantation, metabolic disorders.

The section was founded with the Society for Immunotherapy of Cancer (SITC) under the title "Tumor immunology and biological cancer therapy" and Edited by Pedro Romero.

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  1. The development of Bruton’s tyrosine kinase inhibitors (BTKi) for the treatment of chronic lymphocytic leukaemia (CLL) has provided a highly effective and relatively non-toxic alternative to conventional chemo...

    Authors: Joanne E. Davis, Chia Sharpe, Kylie Mason, Constantine S. Tam, Rachel M. Koldej and David S. Ritchie

    Citation: Journal of Translational Medicine 2021 19:473

    Content type: Research

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  2. Toll-like receptors (TLRs) on neutrophils play a crucial role in detecting pathogens and organ/tissue injury in acute-on-chronic liver failure (ACLF). However, little is known about the exact mechanisms and po...

    Authors: Yi Zhang, Wei Wu, Yijie Wang, Lingjia Tong, Meng Hong, Qi Xia and Zhi Chen

    Citation: Journal of Translational Medicine 2021 19:465

    Content type: Research

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  3. Patients with rheumatoid arthritis (RA) have increased levels of interleukin-18 (IL-18) and decreased levels of IL-18 binding protein (IL-18BP) in the serum and synovial fluid (SF) compared to those in patient...

    Authors: Hong Ki Min, Sehee Kim, Ji-Yeon Lee, Kyoung-Woon Kim, Sang-Heon Lee and Hae-Rim Kim

    Citation: Journal of Translational Medicine 2021 19:392

    Content type: Research

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  4. Neuroinflammation has been proved to play a role in dopaminergic neuronal death in Parkinson’s disease (PD). This link highlights the relevance of the immune response in the progression of the disease. However...

    Authors: Diana D. Álvarez-Luquín, Adrián Guevara-Salinas, Asiel Arce-Sillas, Raquel Espinosa-Cárdenas, Jaquelín Leyva-Hernández, Esteban U. Montes-Moratilla and Laura Adalid-Peralta

    Citation: Journal of Translational Medicine 2021 19:378

    Content type: Research

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  5. Immune cells in the tumor microenvironment have prognostic value. In preclinical models, recruitment and infiltration of these cells depends on immune cell homing (ICH) genes such as chemokines, cell adhesion ...

    Authors: Minyoung Kwak, Gulsun Erdag, Katie M. Leick, Stefan Bekiranov, Victor H. Engelhard and Craig L. Slingluff

    Citation: Journal of Translational Medicine 2021 19:371

    Content type: Research

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  6. Systemic lupus erythematosus (SLE) is an autoimmune disease with a complicated pathogenesis, and its aetiology has not been clearly unveiled. The lack of effective diagnosis and treatment methods makes it nece...

    Authors: Wencong Song, Jie Qiu, Lianghong Yin, Xiaoping Hong, Weier Dai, Donge Tang, Dongzhou Liu and Yong Dai

    Citation: Journal of Translational Medicine 2021 19:362

    Content type: Research

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  7. Silicosis is one of the most common occupational pulmonary fibrosis caused by respirable silica-based particle exposure, with no ideal drugs at present. Metformin, a commonly used biguanide antidiabetic agent,...

    Authors: Demin Cheng, Qi Xu, Yue Wang, Guanru Li, Wenqing Sun, Dongyu Ma, Siyun Zhou, Yi Liu, Lei Han and Chunhui Ni

    Citation: Journal of Translational Medicine 2021 19:349

    Content type: Research

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  8. Kidney transplantation is an optimal method for treatment of end-stage kidney failure. However, kidney transplant rejection (KTR) is commonly observed to have negative effects on allograft function. MicroRNAs ...

    Authors: Yuxin Lin, Liangliang Wang, Wenqing Ge, Yu Hui, Zheng Zhou, Linkun Hu, Hao Pan, Yuhua Huang and Bairong Shen

    Citation: Journal of Translational Medicine 2021 19:346

    Content type: Research

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  9. We tried to elaborate the molecular mechanism of ETS-like transcription factor 4 (ELK4) affecting gastric cancer (GC) progression through M2 polarization of macrophages mediated by lysine-specific demethylase ...

    Authors: Lei Zheng, Hongmei Xu, Ya Di, Lanlan Chen, Jiao Liu, Liying Kang and Liming Gao

    Citation: Journal of Translational Medicine 2021 19:342

    Content type: Research

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  10. Biomarkers for distinguishing psoriatic arthritis (PsA) from psoriasis without arthritis (PsO) are still lacking.

    Authors: Jie Zhu, Ling Han, Ruilai Liu, Zhenghua Zhang, Qiong Huang, Xu Fang, Ke Yang, Guiqin Huang, Zhizhong Zheng, Nikhil Yawalkar, Hui Deng and Kexiang Yan

    Citation: Journal of Translational Medicine 2021 19:331

    Content type: Research

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  11. Tumor microenvironment (TME) is associated with tumor progression and prognosis. Previous studies provided tools to estimate immune and stromal cell infiltration in TME. However, there is still a lack of singl...

    Authors: Zihang Zeng, Jiali Li, Jianguo Zhang, Yangyi Li, Xingyu Liu, Jiarui Chen, Zhengrong Huang, Qiuji Wu, Yan Gong and Conghua Xie

    Citation: Journal of Translational Medicine 2021 19:330

    Content type: Research

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  12. Accumulating evidence suggests tRNA-derived fragments (tRFs) play important roles in cellular homeostasis. Here we aimed to explore aberrant expression of tRFs in CD4+ T cells from patients with systemic lupus er...

    Authors: Guannan Geng, Huijing Wang, Weiwei Xin, Zhe Liu, Jie Chen, Zhang Danting, Fei Han and Shuang Ye

    Citation: Journal of Translational Medicine 2021 19:305

    Content type: Research

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  13. Activator protein-1 (AP1), a c-Fos–JUN transcription factor complex, mediates many cytobiological processes. c-Fos has been implicated in immunoglobulin (Ig)E activation of mast cells (MCs) via high-affinity I...

    Authors: Hui-Na Wang, Kunmei Ji, Li-Na Zhang, Chu-Chu Xie, Wei-Yong Li, Zhen-Fu Zhao and Jia-Jie Chen

    Citation: Journal of Translational Medicine 2021 19:261

    Content type: Research

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  14. Asthma is a frequently occurring respiratory disease with an increasing incidence around the world. Airway inflammation and remodeling are important contributors to the occurrence of asthma. We conducted this ...

    Authors: Wendi Wei, Weida Chen and Naifeng He

    Citation: Journal of Translational Medicine 2021 19:258

    Content type: Research

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  15. Recent studies reporting the intricate crosstalk between cellular and molecular mediators and the lymphatic endothelium in the development of inflammatory bowel diseases (IBD) suggest altered inflammatory cell...

    Authors: Dickson Kofi Wiredu Ocansey, Bing Pei, Xinwei Xu, Lu Zhang, Chinasa Valerie Olovo and Fei Mao

    Citation: Journal of Translational Medicine 2021 19:254

    Content type: Review

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  16. N6-methyl-adenosine (m6A) is one of the most common internal modifications on RNA molecules present in mammalian cells. Deregulation of m6A modification has been recently implicated in many types of human dise...

    Authors: Chang Liu, Zhe Yang, Rong Li, Yanju Wu, Ming Chi, Shuting Gao, Xun Sun, Xin Meng and Biao Wang

    Citation: Journal of Translational Medicine 2021 19:251

    Content type: Review

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  17. Inflammatory bowel disease (IBD) is a chronic and idiopathic inflammatory disorder of the gastrointestinal tract and comprises ulcerative colitis (UC) and Crohn’s disease (CD). Crohn’s disease can affect any p...

    Authors: Ilkyu Park, Jaeeun Jung, Sugi Lee, Kunhyang Park, Jea-Woon Ryu, Mi-Young Son, Hyun-Soo Cho and Dae-Soo Kim

    Citation: Journal of Translational Medicine 2021 19:250

    Content type: Research

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    The Correction to this article has been published in Journal of Translational Medicine 2021 19:329

  18. Programmed cell death ligand-1 (PD-L1) expression is a promising biomarker for identifying treatment related to non-small cell lung cancer (NSCLC). Automated image analysis served as an aided PD-L1 scoring too...

    Authors: Boju Pan, Yuxin Kang, Yan Jin, Lin Yang, Yushuang Zheng, Lei Cui, Jian Sun, Jun Feng, Yuan Li, Lingchuan Guo and Zhiyong Liang

    Citation: Journal of Translational Medicine 2021 19:249

    Content type: Research

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  19. Recently, increased interleukin (IL)-24 expression has been demonstrated in the colon biopsies of adult patients with inflammatory bowel disease (IBD). However, the role of IL-24 in the pathomechanism of IBD i...

    Authors: Anna Ónody, Apor Veres-Székely, Domonkos Pap, Réka Rokonay, Beáta Szebeni, Erna Sziksz, Franz Oswald, Gábor Veres, Áron Cseh, Attila J. Szabó and Ádám Vannay

    Citation: Journal of Translational Medicine 2021 19:237

    Content type: Research

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  20. The main limitation of current immune checkpoint inhibitors (ICIs) in the treatment of cervical cancer comes from the fact that it benefits only a minority of patients. The study aims to develop a classificati...

    Authors: Yimin Li, Shun Lu, Shubin Wang, Xinhao Peng and Jinyi Lang

    Citation: Journal of Translational Medicine 2021 19:222

    Content type: Research

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  21. The gut-brain-microbiota axis (GBMAx) coordinates bidirectional communication between the gut and brain, and is increasingly recognized as playing a central role in physiology and disease. MicroRNAs are import...

    Authors: Liang Zhao, Yingze Ye, Lijuan Gu, Zhihong Jian, Creed M. Stary and Xiaoxing Xiong

    Citation: Journal of Translational Medicine 2021 19:202

    Content type: Review

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  22. Scleroderma is an autoimmune disease that causes dermal fibrosis. It occurs when collagen accumulates in tissue as a result of persistent inflammation. Th17 cells and pro-inflammatory cytokines such as IL-1β,...

    Authors: Jeonghyeon Moon, Seon-yeong Lee, Jeong Won Choi, A Ram Lee, Jin Hee Yoo, Su-Jin Moon, Sung-Hwan Park and Mi-La Cho

    Citation: Journal of Translational Medicine 2021 19:192

    Content type: Research

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    The Correction to this article has been published in Journal of Translational Medicine 2021 19:266

  23. T cells and B cells play a key role in alloimmune responses. We aimed to characterize the shift of T cell subsets and B cell subsets during acute hepatic rejection, and further determine whether they could ser...

    Authors: Ji-Qiao Zhu, Jing Wang, Xian-Liang Li, Wen-Li Xu, Shao-cheng Lv, Xin Zhao, Ren Lang and Qiang He

    Citation: Journal of Translational Medicine 2021 19:187

    Content type: Research

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  24. New medications for Rheumatoid Arthritis (RA) have emerged in the last decades, including Disease Modifying Antirheumatic Drugs (DMARDs) and biologics. However, there is no known cure, since a significant prop...

    Authors: Lydia Ntari, Christoforos Nikolaou, Ksanthi Kranidioti, Dimitra Papadopoulou, Eleni Christodoulou-Vafeiadou, Panagiotis Chouvardas, Florian Meier, Christina Geka, Maria C. Denis, Niki Karagianni and George Kollias

    Citation: Journal of Translational Medicine 2021 19:165

    Content type: Research

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  25. Osteoarthritis (OA) is a disease of the entire joint involving synovial fibrosis and inflammation. Pathological changes to the synovium can accelerate the progression of OA. Pirfenidone (PFD) is a potent anti-...

    Authors: Qilu Wei, Ning Kong, Xiaohui Liu, Run Tian, Ming Jiao, Yiyang Li, Huanshuai Guan, Kunzheng Wang and Pei Yang

    Citation: Journal of Translational Medicine 2021 19:157

    Content type: Research

    Published on:

    The Correction to this article has been published in Journal of Translational Medicine 2021 19:434

  26. Modification of the gut microbiota by antibiotics may influence the disease susceptibility and immunological responses. Infants in the neonatal intensive care unit (NICU) subjected to frequent antibiotics and ...

    Authors: Xiao Ran, Yu He, Qing Ai and Yuan Shi

    Citation: Journal of Translational Medicine 2021 19:155

    Content type: Research

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  27. Lung cancer is the most common cancer and cause of cancer‐related mortality worldwide, increasing evidence indicated that there was a significant correlation between tumors and the long non‐coding RNAs (lncRNA...

    Authors: Lan Mu, Ke Ding, Ranran Tu and Wei Yang

    Citation: Journal of Translational Medicine 2021 19:127

    Content type: Research

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  28. Acute lung injury (ALI)/acute respiratory distress syndrome (ARDS) induces uncontrolled and self-amplified pulmonary inflammation, and has high morbidity and mortality rates in critically ill patients. In rece...

    Authors: Jiucui Li, Kongmiao Lu, Fenglan Sun, Shanjuan Tan, Xiao Zhang, Wei Sheng, Wanming Hao, Min Liu, Weihong Lv and Wei Han

    Citation: Journal of Translational Medicine 2021 19:96

    Content type: Research

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  29. Regimens combining pemetrexed (PEM) and immune checkpoint inhibitors (ICIs) targeting programmed cell death-1 (PD-1) or programmed death-ligand 1 (PD-L1) are widely used for the treatment of advanced non-squam...

    Authors: Issei Sumiyoshi, Takahiro Okabe, Shinsaku Togo, Haruhi Takagi, Hiroaki Motomura, Yusuke Ochi, Naoko Shimada, Mizuki Haraguchi, Rina Shibayama, Yuichi Fujimoto, Junko Watanabe, Moe Iwai, Kotaro Kadoya, Shin-ichiro Iwakami and Kazuhisa Takahashi

    Citation: Journal of Translational Medicine 2021 19:92

    Content type: Research

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  30. Autoantibody production against endogenous cellular components is pathogenic feature of systemic lupus erythematosus (SLE). Follicular helper T (TFH) cells aid in B cell differentiation into autoantibody-producin...

    Authors: Se Gwang Jang, Jaeseon Lee, Seung-Min Hong, Young-Seok Song, Min Jun Kim, Seung-Ki Kwok, Mi-La Cho and Sung-Hwan Park

    Citation: Journal of Translational Medicine 2021 19:86

    Content type: Research

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  31. Systemic lupus erythematosus (SLE) is a multisystemic, chronic inflammatory disease characterized by destructive systemic organ involvement, which could cause the decreased functional capacity, increased morbi...

    Authors: Xingwang Zhao, Longlong Zhang, Juan Wang, Min Zhang, Zhiqiang Song, Bing Ni and Yi You

    Citation: Journal of Translational Medicine 2021 19:35

    Content type: Research

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    The Correction to this article has been published in Journal of Translational Medicine 2021 19:64

  32. Although the tumour immune microenvironment is known to significantly influence immunotherapy outcomes, its association with changes in gene expression patterns in hepatocellular carcinoma (HCC) during immunot...

    Authors: Xinyu Gu, Jun Guan, Jia Xu, Qiuxian Zheng, Chao Chen, Qin Yang, Chunhong Huang, Gang Wang, Haibo Zhou, Zhi Chen and Haihong Zhu

    Citation: Journal of Translational Medicine 2021 19:26

    Content type: Research

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  33. Immune checkpoint inhibitors (ICIs) have become a frontier in the field of clinical technology for advanced non-small cell lung cancer (NSCLC). Currently, the predictive biomarker of ICIs mainly including the ...

    Authors: Li Wang, Zhixuan Ren, Bentong Yu and Jian Tang

    Citation: Journal of Translational Medicine 2021 19:22

    Content type: Research

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  34. Metabolic cell features are able to give reliable information on cell functional state. Thus, metabolic potential assessment of T cells in malignancy setting represents a promising area, especially in adoptive...

    Authors: Patricia Mercier-Letondal, Chrystel Marton, Yann Godet and Jeanne Galaine

    Citation: Journal of Translational Medicine 2021 19:21

    Content type: Methodology

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  35. Rheumatoid arthritis (RA) is the most common chronic autoimmune connective tissue disease. However, early RA is difficult to diagnose due to the lack of effective biomarkers. This study aimed to identify new b...

    Authors: Qi Cheng, Xin Chen, Huaxiang Wu and Yan Du

    Citation: Journal of Translational Medicine 2021 19:18

    Content type: Research

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  36. Inflammatory disorders like diabetes, systemic lupus erythematodes, inflammatory lung diseases, rheumatoid arthritis and multiple sclerosis, but also rejection of transplanted organs and GvHD, form a major bur...

    Authors: Sija Landman, Chiel van der Horst, Piet E. J. van Erp, Irma Joosten, Rob de Vries and Hans J. P. M. Koenen

    Citation: Journal of Translational Medicine 2021 19:11

    Content type: Review

    Published on:

  37. Ankylosing spondylitis (AS) is characterized by excessive production of inflammatory cytokines. Recent evidence suggests that inflammation underlies the neurodegenerative process of Parkinson’s disease (PD). W...

    Authors: Fu-Chiang Yeh, Hsiang-Cheng Chen, Yu-Ching Chou, Cheng-Li Lin, Chia-Hung Kao, Hsin-Yi Lo, Feng-Cheng Liu and Tse-Yen Yang

    Citation: Journal of Translational Medicine 2020 18:455

    Content type: Research

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  38. Dysregulation of transcription and cytokine expression has been implicated in the pathogenesis of a variety inflammatory diseases. The resulting imbalance between inflammatory and resolving transcriptional pro...

    Authors: Gregory Thomas, Elizabeth Frederick, Lisa Thompson, Raphael Bar-Or, Yetti Mulugeta, Melissa Hausburg, Michael Roshon, Charles Mains and David Bar-Or

    Citation: Journal of Translational Medicine 2020 18:452

    Content type: Research

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  39. Thymocyte-expressed, positive selection-associated 1 (Tespa1) is a critical signaling molecule in thymocyte development. This study aimed to investigate the regulatory effect of Tespa1 on mast cells in the pat...

    Authors: Ruhui Yang, Guangli Wang, Lingyun Li, Hanjiang He, Mingzhu Zheng, Linrong Lu and Songquan Wu

    Citation: Journal of Translational Medicine 2020 18:444

    Content type: Research

    Published on:

  40. Immunity reaction plays an essential role in periodontitis progress and we aim to investigate the underlying regulatory network of immune reactions in periodontitis.

    Authors: Xiaoqi Zhang, Qingxuan Wang, Xinyu Yan, Yue Shan, Lu Xing, Minqi Li, Hu Long and Wenli Lai

    Citation: Journal of Translational Medicine 2020 18:438

    Content type: Research

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  41. Neutrophil extracellular traps (NETs) from patients with systemic lupus erythematosus (SLE) are characterized by lower ubiquitylation and myeloperoxidase (MPO) as a substrate. The structural and functional eff...

    Authors: Daniel Alberto Carrillo-Vázquez, Eduardo Jardón-Valadez, Jiram Torres-Ruiz, Guillermo Juárez-Vega, José Luis Maravillas-Montero, David Eduardo Meza-Sánchez, María Lilia Domínguez-López, Jorge Carlos Alcocer Varela and Diana Gómez-Martín

    Citation: Journal of Translational Medicine 2020 18:429

    Content type: Research

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  42. Foxp3+ regulatory T cells (Tregs) play essential roles in immune homeostasis and repair of damaged lung tissue. We hypothesized that patients whose lung injury resolves quickly, as measured by time to liberation ...

    Authors: Dustin L. Norton, Agathe Ceppe, Miriya K. Tune, Matthew McCravy, Thomas Devlin, M. Bradley Drummond, Shannon S. Carson, Benjamin G. Vincent, Robert S. Hagan, Hong Dang, Claire M. Doerschuk and Jason R. Mock

    Citation: Journal of Translational Medicine 2020 18:427

    Content type: Research

    Published on:

  43. Numerous tissue-derived factors have been postulated to be involved in tissue migration of circulating monocytes. The aim of this study was to evaluate whether a defined hypoxic gradient can induce directed mi...

    Authors: Lars Hummitzsch, Rouven Berndt, Matthias Kott, Rene Rusch, Fred Faendrich, Matthias Gruenewald, Markus Steinfath, Martin Albrecht and Karina Zitta

    Citation: Journal of Translational Medicine 2020 18:404

    Content type: Research

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  44. In Crohn’s disease (CD), one of the major inflammatory bowel disease (IBD) in human beings, there is over-expression of Smad7, an intracellular inhibitor of the suppressive cytokine TGF-β1. The aim of this stu...

    Authors: Francesca Zorzi, Emma Calabrese, Davide Di Fusco, Elena De Cristofaro, Livia Biancone, Sara Casella, Giampiero Palmieri and Giovanni Monteleone

    Citation: Journal of Translational Medicine 2020 18:395

    Content type: Research

    Published on:

  45. Rheumatoid arthritis (RA) and periodontitis (PD) are proven to share common risk markers, including genetic factors. In the present study we focused on genetic variants in PTPN22 (rs2476601), PADI4 (rs2240340), C...

    Authors: Susanne Schulz, Pauline Zimmer, Natalie Pütz, Elisa Jurianz, Hans-Günter Schaller and Stefan Reichert

    Citation: Journal of Translational Medicine 2020 18:389

    Content type: Research

    Published on:

  46. Autoimmune hepatitis (AIH) is a liver disease characterized by the autoimmune-induced injury of hepatocytes which can lead to cirrhosis and hepatic failure. The diagnosis and disease management of AIH patients...

    Authors: Rui Wu, Yan Liu, Ruyu Yan, Xiaoyu Liu and Liang Duan

    Citation: Journal of Translational Medicine 2020 18:384

    Content type: Research

    Published on:

  47. The study of localized immune-related factors has proven beneficial for a variety of conditions, and one area of interest in the field of orthopaedics is the impact of implants and localized infections on immu...

    Authors: Nicole Prince, Julia A. Penatzer, Matthew J. Dietz and Jonathan W. Boyd

    Citation: Journal of Translational Medicine 2020 18:330

    Content type: Research

    Published on:

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