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Immunobiology and Immunotherapy

Section edited by Alessandra Cesano

The Immunobiology and Immunotherapy section aims to enrich the communication between basic biological and immunological sciences and the clinical investigation arena.

As immunology has evolved to be a central discipline connected to a wide range of therapeutic areas, the number and diversity of platform technologies has also increased, spanning small molecules, biologics, microbial vectors and cells. Such levels of activity require appropriate means to share new knowledge and to catalyze the development of the field. This section aims to provide such a platform and welcomes submissions across all disciplines, including inflammation, autoimmunity, transplantation, metabolic disorders.

The section was founded with the Society for Immunotherapy of Cancer (SITC) under the title "Tumor immunology and biological cancer therapy" and Pedro Romero was the founding Section Editor.

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  1. Inflammatory bowel disease (IBD) represents a group of recurrent chronic inflammatory disorders associated with autoimmune dysregulation, typically characterized by neutrophil infiltration and mucosal inflamma...

    Authors: Chengli Zheng, Jiekai Li, Hailin Chen, Xiaolin Ma, Tianyu Si and Wenwei Zhu
    Citation: Journal of Translational Medicine 2024 22:813
    Content type: Review Published on:

  2. Apoptotic bodies (ABs) are extracellular vesicles released during apoptosis and possess diverse biological activities. Initially, ABs were regarded as garbage bags with the main function of apoptotic cell clea...

    Authors: Xiaoyu Miao, Xiaojin Wu, Wenran You, Kaini He, Changzhong Chen, Janak Lal Pathak and Qing Zhang
    Citation: Journal of Translational Medicine 2024 22:810
    Content type: Review Published on:

  3. Difficult-to-treat Rheumatoid arthritis (D2T RA) is primarily characterised by failure of at least two different mechanism of action biologic/targeted synthetic disease-modifying antirheumatic drug (DMARDs) wi...

    Authors: Qin-Yi Su, Jing Luo, Yan Zhang, Qian Li, Zhong-Qing Jiang, Zi-Rong Wen, Yu-Ying Wang, Mo-Ran Shi and Sheng-Xiao Zhang
    Citation: Journal of Translational Medicine 2024 22:795
    Content type: Review Published on:

  4. Although immune checkpoint inhibitors (anti-PD-1 antibody, anti-PD-L1 antibody, and anti-CTLA-4 antibody) have displayed considerable success in the treatment of malignant tumors, the therapeutic effect is sti...

    Authors: Xin Su, Jian Li, Xiao Xu, Youbao Ye, Cailiu Wang, Guanglong Pang, Wenxiu Liu, Ang Liu, Changchun Zhao and Xiangyong Hao
    Citation: Journal of Translational Medicine 2024 22:751
    Content type: Review Published on:

  5. An increasing number of clinical studies have begun to explore combination strategies with immune checkpoint inhibitors, aiming to present new opportunities for overcoming anti-PD-1 treatment resistance in gas...

    Authors: Guanjun Li, Xiaohan Liu, Chunhui Gu, Guichuang Ma, Shaowei Li, Zhenfeng Ma, Yanqiu Xiong, Yu Jiang, Qiong Huang, Jianhua Wu, Zhenzhen Wu, Wangjun Liao, Qijing Wu and Min Shi
    Citation: Journal of Translational Medicine 2024 22:718
    Content type: Research Published on:

  6. The T-helper 17 (Th17) cell and regulatory T cell (Treg) axis plays a crucial role in the development of multiple sclerosis (MS), which is regarded as an immune imbalance between pro-inflammatory cytokines and...

    Authors: Huiru Hu, Hui Li, Ruoyu Li, Peidong Liu and Hongbo Liu
    Citation: Journal of Translational Medicine 2024 22:663
    Content type: Review Published on:

  7. Inhibition of kinases is the ever-expanding therapeutic approach to various types of cancer. Typically, assessment of the treatment response is accomplished by standard, volumetric imaging procedures, performe...

    Authors: Kavindra Nath, Pradeep K. Gupta, Johnvesly Basappa, Shengchun Wang, Neil Sen, Cosimo Lobello, Jyoti S. Tomar, Alexander A. Shestov, Stepan Orlovskiy, Fernando Arias-Mendoza, Hilka Rauert-Wunderlich, David S. Nelson, Jerry D. Glickson and Mariusz A. Wasik
    Citation: Journal of Translational Medicine 2024 22:622
    Content type: Research Published on:

  8. The lack of distinct biomarkers for pancreatic cancer is a major cause of early-stage detection difficulty. The pancreatic cancer patient group with high metabolic tumor volume (MTV), one of the values measure...

    Authors: Baek Gil Kim, Sung Hwan Lee, Yeonsue Jang, Suki Kang, Chang Moo Kang and Nam Hoon Cho
    Citation: Journal of Translational Medicine 2024 22:453
    Content type: Research Published on:

  9. Immune checkpoint inhibitors (ICIs) induce acute interstitial nephritis (AIN) in 2–5% of patients, with a clearly higher incidence when they are combined with platinum derivatives. Unfortunately, suitable dise...

    Authors: Laura Martinez Valenzuela, Francisco Gómez-Preciado, Jordi Guiteras, Paula Antón Pampols, Montserrat Gomà, Xavier Fulladosa, Josep Maria Cruzado, Joan Torras and Juliana Draibe
    Citation: Journal of Translational Medicine 2024 22:421
    Content type: Research Published on:

  10. Peritoneal carcinomatosis (PC) is a complex manifestation of abdominal cancers, with a poor prognosis and limited treatment options. Recent work identifying high concentrations of the cytokine interleukin-6 (I...

    Authors: Neda Dadgar, Christopher Sherry, Jenna Zimmerman, Hyun Park, Catherine Lewis, Albert Donnenberg, Ali H. Zaidi, Yong Fan, Kunhong Xiao, David Bartlett, Vera Donnenberg and Patrick L. Wagner
    Citation: Journal of Translational Medicine 2024 22:402
    Content type: Review Published on:

  11. Psoriasis is a chronic immune-mediated skin condition. Although biologic treatments are effective in controlling psoriasis, some patients do not respond or lose response to these therapies. Thus, new strategie...

    Authors: Yunxiong Wei, Guangyong Sun, Yang Yang, Mingyang Li, Shimeng Zheng, Xiyu Wang, Xinjie Zhong, Zihan Zhang, Xiaotong Han, Haiyan Cheng, Dong Zhang and Xueling Mei
    Citation: Journal of Translational Medicine 2024 22:328
    Content type: Research Published on:

  12. Crohn's disease (CD) is a disease characterized by intestinal immune dysfunction, often accompanied by metabolic abnormalities. Disturbances in lactate metabolism have been found in the intestine of patients w...

    Authors: Jingtong Wu, Yinyin Lv, Pei Hao, Ziyi Zhang, Yongtian Zheng, Ermei Chen and Yanyun Fan
    Citation: Journal of Translational Medicine 2024 22:300
    Content type: Research Published on:

  13. Resident memory T (Trm) cells which are specifically located in non-lymphoid tissues showed distinct phenotypes and functions compared to circulating memory T cells and were vital for the initiation of robust ...

    Authors: Jialing Fang, Jun Lei, Boxiao He, Yankang Wu, Peng Chen, Zaiqiao Sun, Ning Wu, Yafei Huang, Pengcheng Wei, Lei Yin and Yongshun Chen
    Citation: Journal of Translational Medicine 2024 22:203
    Content type: Research Published on:

  14. Soluble oligomeric forms of Tau protein have emerged as crucial players in the propagation of Tau pathology in Alzheimer’s disease (AD). Our objective is to introduce a single-domain antibody (sdAb) named 2C5 ...

    Authors: Nicolas De Leiris, Pascale Perret, Charlotte Lombardi, Bülent Gözel, Sabine Chierici, Philippe Millet, Marlène Debiossat, Sandrine Bacot, Benjamin B. Tournier, Patrick Chames, Jean-Luc Lenormand, Catherine Ghezzi, Daniel Fagret and Marcelle Moulin
    Citation: Journal of Translational Medicine 2024 22:163
    Content type: Research Published on:

  15. Colorectal cancer (CRC) has been the third most prevalent cancer worldwide. Liver metastasis is the critical factor for the poor prognosis of CRC. Here, we investigated the expression and role of PLOD3 in CRC.

    Authors: Min Ding, Cheng Wang, Junhong Hu, Junjun She, Ruoyu Shi, Yixuan Liu, Qi Sun, Haojun Xu, Guoren Zhou, Wenlan Wu and Hongping Xia
    Citation: Journal of Translational Medicine 2024 22:30
    Content type: Research Published on:

  16. CD8+ T cells are the executor in adaptive immune response, especially in anti-tumor immunity. They are the subset immune cells that are of high plasticity and multifunction. Their development, differentiation, ac...

    Authors: Jinghong Wu, Zhendong Lu, Hong Zhao, Mingjun Lu, Qing Gao, Nanying Che, Jinghui Wang and Teng Ma
    Citation: Journal of Translational Medicine 2023 21:905
    Content type: Review Published on:

  18. AMP-activated protein kinase (AMPK) is a ubiquitous sensor of energy and nutritional status in eukaryotic cells. It plays a key role in regulating cellular energy homeostasis and multiple aspects of cell metab...

    Authors: Yinxing Cui, Junhua Chen, Zhao Zhang, Houyin Shi, Weichao Sun and Qian Yi
    Citation: Journal of Translational Medicine 2023 21:892
    Content type: Review Published on:

  19. Lung neuroendocrine neoplasms (LungNENs) comprise a heterogeneous group of tumors ranging from indolent lesions with good prognosis to highly aggressive cancers. Carcinoids are the rarest LungNENs, display low...

    Authors: Ricardo Blázquez-Encinas, Víctor García-Vioque, Teresa Caro-Cuenca, María Trinidad Moreno-Montilla, Federica Mangili, Emilia Alors-Pérez, Sebastian Ventura, Aura D. Herrera-Martínez, Paula Moreno-Casado, Marco A. Calzado, Ángel Salvatierra, María A. Gálvez-Moreno, Lynnette Fernandez-Cuesta, Matthieu Foll, Raúl M. Luque, Nicolas Alcala…
    Citation: Journal of Translational Medicine 2023 21:879
    Content type: Research Published on:

  20. Pancreatic cancer is a lethal disease with a high mortality rate. The difficulty of early diagnosis is one of its primary causes. Therefore, we aimed to discover non-invasive biomarkers that facilitate the ear...

    Authors: Youngmin Han, Keum Ji Jung, Unchong Kim, Chan Il Jeon, Kwangbae Lee and Sun Ha Jee
    Citation: Journal of Translational Medicine 2023 21:878
    Content type: Research Published on:

  21. Psoriasis is an inflammatory disease mediated by helper T (Th)17 and Th1 cells. MicroRNA-125a (miR-125a) is reduced in the lesional skin of psoriatic patients. However, the mechanism by which miR-125a particip...

    Authors: Kexiang Yan, Fuxin Zhang, Jie Ren, Qiong Huang, Nikhil Yawalkar and Ling Han
    Citation: Journal of Translational Medicine 2023 21:678
    Content type: Research Published on:

  22. Rheumatoid arthritis (RA) is a chronic inflammatory illness that mostly affects the joints of the hands and feet and can reduce life expectancy by an average of 3 to 10 years. Although tremendous progress has ...

    Authors: Yu Cao, Ying Yang, Qingfeng Hu and Guojun Wei
    Citation: Journal of Translational Medicine 2023 21:616
    Content type: Research Published on:

  23. Ankylosing spondylitis (AS) is an autoimmune disease with a genetic correlation and is characterized by inflammation in the axial skeleton and sacroiliac joints. Many AS patients also have inflammatory bowel d...

    Authors: Xinzhe Feng, Shanbang Zhu, Junjie Qiao, Zhou Ji, Bole Zhou and Weidong Xu
    Citation: Journal of Translational Medicine 2023 21:573
    Content type: Research Published on:

  24. Celiac disease (CeD) is a primary malabsorption syndrome with no specific therapy, which greatly affects the quality of life. Since the pathogenesis of CeD remains riddled, based on multiple transcriptome prof...

    Authors: Shuze Chen, Xiuying Liu, Zhi Wang, Dekai Zheng, Ying Wang, Yiling Yan, Xiaojie Peng, Qiujuan Ye and Ye Chen
    Citation: Journal of Translational Medicine 2023 21:497
    Content type: Research Published on:

  25. We sought to identify novel molecular subtypes of ulcerative colitis (UC) based on large-scale cohorts and establish a clinically applicable subtyping system for the precision treatment of the disease.

    Authors: Shaocong Mo, Bryan Jin, Yujen Tseng, Lingxi Lin, Lishuang Lin, Xin Shen, Huan Song, Mingjia Kong, Zhongguang Luo, Yiwei Chu, Chen Jiang, Zhiwei Cao, Jie Liu and Feifei Luo
    Citation: Journal of Translational Medicine 2023 21:466
    Content type: Research Published on:

  26. Upregulation of the PD-L1 (CD274) immune checkpoint ligand on the tumor surface facilitates tumor immune escape and limits the application of immunotherapy in various cancers, including breast cancer. However,...

    Authors: Xinrui Dong, Huijuan Dai, Yanping Lin, Xiaonan Sheng, Ye Li, Yaohui Wang, Xueli Zhang, Shuheng Jiang, Wenjin Yin and Jinsong Lu
    Citation: Journal of Translational Medicine 2023 21:400
    Content type: Research Published on:

  27. The ubiquitin protein ligase E3C (UBE3C) has been reported to play an oncogenic role in breast cancer (BRCA). This work further investigates the effect of UBE3C on the radioresistance of BRCA cells.

    Authors: Yansu Wang, Ming Liu, Xiaoqian Liu and Xianling Guo
    Citation: Journal of Translational Medicine 2023 21:321
    Content type: Research Published on:

  28. The clinical heterogeneity of SLE with its complex pathogenesis remains challenging as we strive to provide optimal management. The contribution of platelets to endovascular homeostasis, inflammation and immun...

    Authors: MacIntosh G. Cornwell, Hanane El Bannoudi, Elliot Luttrell-Williams, Alexis Engel, Tessa J. Barrett, Khrystyna Myndzar, Peter Izmirly, H. Michael Belmont, Robert Clancy, Kelly V. Ruggles, Jill P. Buyon and Jeffrey S. Berger
    Citation: Journal of Translational Medicine 2023 21:247
    Content type: Research Published on:

  29. Chimeric antigen receptor macrophage (CAR-M) therapy is a novel cancer immunotherapy approach that integrates CAR structure and macrophage functions. CAR-M therapy has shown unique and impressive antitumor eff...

    Authors: Yi Huo, Han Zhang, Longqi Sa, Wenjing Zheng, Yang He, Haohan Lyu, Mengjie Sun, Lingling Zhang, Lequn Shan, Angang Yang and Tao Wang
    Citation: Journal of Translational Medicine 2023 21:225
    Content type: Research Published on:

  30. Despite remarkable progress, the immunotherapies currently used in the clinic, such as immune checkpoint blockade (ICB) therapy, still have limited efficacy against many types of solid tumors. One major barrie...

    Authors: Meir Azulay, Michal Shahar, Eitan Shany, Eti Elbaz, Sveta Lifshits, Marie Törngren, Adam Friedmann, Robert Kramer and Gunnar Hedlund
    Citation: Journal of Translational Medicine 2023 21:222
    Content type: Research Published on:

  31. Gastrointestinal stromal tumors (GISTs) are the prevailing sarcomas of the gastrointestinal tract. Tyrosine kinase inhibitors (TKIs) therapy, exemplified by Imatinib mesylate (IM), constitutes the established ...

    Authors: Yu Zhao, Zuyi Weng, Xuan Zhou, Zhi Xu, Bei Cao, Bin Wang and Juan Li
    Citation: Journal of Translational Medicine 2023 21:219
    Content type: Research Published on:

  32. Psoriasis is a common, chronic and relapsing immune-related inflammatory dermal disease. Patients with psoriasis suffering from the recurrences is mainly caused by immune response disorder. Thus, our study is ...

    Authors: Yingxi Li, Lin Li, Yao Tian, Jing Luo, Junkai Huang, Litao Zhang, Junling Zhang, Xiaoxia Li and Lizhi Hu
    Citation: Journal of Translational Medicine 2023 21:182
    Content type: Research Published on:

  33. Muscle-invasive urothelial bladder cancer (MIBC) is associated with limited response rates to systemic therapy, risk of recurrence and death. Tumor infiltrating immune cells have been associated with outcome a...

    Authors: Florestan J. Koll, Severine Banek, Luis Kluth, Jens Köllermann, Katrin Bankov, Felix K.-H. Chun, Peter J. Wild, Andreas Weigert and Henning Reis
    Citation: Journal of Translational Medicine 2023 21:124
    Content type: Research Published on:

  34. Inadequate immunity caused by poor immune surveillance leads to tumorigenesis, while excessive immunity due to breakdown of immune tolerance causes autoimmune genesis. Although the function of immunity during ...

    Authors: Yuan Sui, Shuping Li, Xue-Qi Fu, Zhizhuang Joe Zhao and Shu Xing
    Citation: Journal of Translational Medicine 2023 21:109
    Content type: Research Published on:

  35. CD4+ cytotoxic T cells (CD4 CTLs) are CD4+ T cells with major histocompatibility complex-II-restricted cytotoxic function. Under pathologic conditions, CD4 CTLs hasten the development of autoimmune disease or vir...

    Authors: Ziyi Chen, Meng Zhang, Yufeng Liu, Zhe Chen, Ling Wang, Wenjuan Wang, Jincheng Wang, Mingqian He, Bingyin Shi and Yue Wang
    Citation: Journal of Translational Medicine 2023 21:74
    Content type: Research Published on:

  36. Eosinophilic esophagitis (EoE) is a chronic immune-mediated rare disease, characterized by esophageal dysfunctions. It is likely to be primarily activated by food antigens and is classified as a chronic diseas...

    Authors: Luca Massimino, Alberto Barchi, Francesco Vito Mandarino, Salvatore Spanò, Luigi Antonio Lamparelli, Edoardo Vespa, Sandro Passaretti, Laurent Peyrin-Biroulet, Edoardo Vincenzo Savarino, Vipul Jairath, Federica Ungaro and Silvio Danese
    Citation: Journal of Translational Medicine 2023 21:46
    Content type: Research Published on:

  37. Ulcerative colitis (UC) is a form of chronic inflammatory bowel disease of nonspecific origin. This study used an RNA-Sequencing (RNA-Seq) approach to evaluate the transcriptomic landscape of a well-stratified...

    Authors: Xiaoli Pang, Hongxiao Song, Xiaolu Li, Fengchao Xu, Bingxun Lei, Fei Wang, Jing Xu, Lingli Qi, Libo Wang and Guangyun Tan
    Citation: Journal of Translational Medicine 2023 21:30
    Content type: Research Published on:

  38. Breast cancer is a complex disease with a highly immunosuppressive tumor microenvironment, and has limited clinical response to immune checkpoint blockade (ICB) therapy. T-helper 2 (Th2) cells, an important co...

    Authors: Yuru Chen, Jiazheng Sun, Yachan Luo, Jiazhou Liu, Xiaoyu Wang, Rui Feng, Jing Huang, Huimin Du, Qin Li, Jinxiang Tan, Guosheng Ren, Xiaoyi Wang and Hongzhong Li
    Citation: Journal of Translational Medicine 2022 20:615
    Content type: Research Published on:

  39. To identify novel DNA methylation-regulated differentially expressed genes (MeDEGs) in RA by integrated analysis of DNA methylation and RNA-Seq data.

    Authors: Runrun Zhang, Cen Chang, Yehua Jin, LingXia Xu, Ping Jiang, Kai Wei, Linshuai Xu, Shicheng Guo, Songtao Sun and Dongyi He
    Citation: Journal of Translational Medicine 2022 20:481
    Content type: Research Published on:

  40. Immunotherapy has dramatically improved cancer treatment by inhibiting or activating specific cell receptors, thus unleashing the host anti-tumor response. However, the engagement of the three main immune chec...

    Authors: Claudia Giampietri, Francesca Scatozza, Elena Crecca, Virginia Vigiano Benedetti, Pier Giorgio Natali and Antonio Facchiano
    Citation: Journal of Translational Medicine 2022 20:467
    Content type: Research Published on:

  41. Metastasis is a major obstacle in the treatment of cervical cancer (CC), and SPOP-mediated regulatory effects are involved in metastasis. However, the mechanisms have not been fully elucidated.

    Authors: Jiangchun Wu, Yong Wu, Qinhao Guo, Siyu chen, Simin Wang, Xiaohua Wu, Jun Zhu and Xingzhu Ju
    Citation: Journal of Translational Medicine 2022 20:384
    Content type: Research Published on:

  42. The IO Score is a 27-gene immuno-oncology (IO) classifier that has previously predicted benefit to immune checkpoint inhibitor (ICI) therapy in triple negative breast cancer (TNBC) and non-small cell lung canc...

    Authors: Robert S. Seitz, Michael E. Hurwitz, Tyler J. Nielsen, Daniel B. Bailey, Matthew G. Varga, Brian Z. Ring, Carrie F. Metts, Brock L. Schweitzer, Kimberly McGregor and Douglas T. Ross
    Citation: Journal of Translational Medicine 2022 20:370
    Content type: Research Published on:

  43. To construct a predictive model of immunotherapy efficacy for patients with lung squamous cell carcinoma (LUSC) based on the degree of tumor-infiltrating immune cells (TIIC) in the tumor microenvironment (TME).

    Authors: Lingge Yang, Shuli Wei, Jingnan Zhang, Qiongjie Hu, Wansong Hu, Mengqing Cao, Long Zhang, Yongfang Wang, Pingli Wang and Kai Wang
    Citation: Journal of Translational Medicine 2022 20:364
    Content type: Research Published on:

  44. Approximately 8–9% of the world’s population is affected by autoimmune diseases, and yet the mechanism of autoimmunity trigger is largely understudied. Two unique cell death modalities, ferroptosis and pyropto...

    Authors: Danfeng Zhang, Yadan Li, Chunyan Du, Lina Sang, Liu Liu, Yingmei Li, Fang Wang, Wenjuan Fan, Ping Tang, Sidong Zhang, Dandan Chen, Yanmei Wang, Xiaoyi Wang, Xinsheng Xie, Zhongxing Jiang, Yongping Song…
    Citation: Journal of Translational Medicine 2022 20:363
    Content type: Research Published on:

  45. Except for B7-CD28 family members, more novel immune checkpoints are being discovered. They are closely associated with tumor immune microenvironment and regulate the function of many immune cells. Various can...

    Authors: Nan Sun, Yuejun Luo, Bo Zheng, Zhihui Zhang, Chaoqi Zhang, Zhen Zhang, Guochao Zhang, Fengwei Tan, Qi Xue, Shugeng Gao and Jie He
    Citation: Journal of Translational Medicine 2022 20:332
    Content type: Research Published on:

  46. Ulcerative colitis (UC) is a heterogeneous disorder with complex pathogenesis. Therefore, in the present study, we aimed to assess genome-wide DNA methylation changes associated explicitly with the pathogenesi...

    Authors: Hao-ming Xu, Jing Xu, Mei-feng Yang, Yu-jie Liang, Quan-zhou Peng, Yuan Zhang, Cheng-mei Tian, Yu-qiang Nie, Li-sheng Wang, Jun Yao and De-feng Li
    Citation: Journal of Translational Medicine 2022 20:289
    Content type: Research Published on:

  47. TIGIT/CD155 has attracted widespread attention as a new immune checkpoint and a potential target for cancer immunotherapy. In our study, we evaluated the role of TIGIT/CD155 checkpoints in the progression of c...

    Authors: Lu Liu, Aihong Wang, Xiaoli Liu, Sai Han, Yu Sun, Junhua Zhang, Lingyu Guo and Youzhong Zhang
    Citation: Journal of Translational Medicine 2022 20:280
    Content type: Research Published on:

  48. High immune infiltration is associated with favourable prognosis in patients with non-small-cell lung cancer (NSCLC), but an automated workflow for characterizing immune infiltration, with high validity and re...

    Authors: Huan Lin, Xipeng Pan, Zhengyun Feng, Lixu Yan, Junjie Hua, Yanting Liang, Chu Han, Zeyan Xu, Yumeng Wang, Lin Wu, Yanfen Cui, Xiaomei Huang, Zhenwei Shi, Xin Chen, Xiaobo Chen, Qingling Zhang…
    Citation: Journal of Translational Medicine 2022 20:261
    Content type: Research Published on:
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