Skip to main content

Emerging Therapeutics

Section edited by Gennaro Ciliberto

© Parilov / stock.adobe.comThe Emerging Therapeutics section is dedicated to the wave of emerging therapeutics arising from the intense research efforts and therapeutic breakthroughs based on recent scientific and technological developments. 

The section is interested in original papers, reviews and perspectives on the advancements in the field, including genetic vaccines, monoclonal antibodies, CAR-Ts, gene therapy with viral vectors, clinical applications of CRISPR/CAS9 gene editing, microbiota-modulating approaches, ‘omics approaches, emerging therapeutics from the development of new technologies for drug development, and discovery of new intervention targets and the possibility for new drug combinations.

  1. Liver cancer is the fifth leading cause of cancer death worldwide, but early diagnosis and treatment of liver cancer remains a clinical challenge. How to screen and diagnose liver cancer early and prolong the ...

    Authors: Lihua Wang, Zheng Zhu, Qi Liang, Yecheng Tao, Gaowei Jin, Yaoyao Zhong, Jichen Dai, Ruixia Dai, Zhixiang Wang, Junbo Chen, Lingjie Zhou, Shouyu Ke, Bin Zheng, Linhua Lan, Xiaokun Lin and Tongke Chen
    Citation: Journal of Translational Medicine 2022 20:530
  2. Non-small cell lung cancer (NSCLC) is the most common lung cancer with high mortality across the world, but it is challenging to develop an effective therapy for NSCLC. Celastrol is a natural bioactive compoun...

    Authors: Zhucheng Zhao, Yanmao Wang, Yuyan Gong, Xian Wang, Luyao Zhang, Haiyang Zhao, Jifa Li, Jiandong Zhu, Xiaoying Huang, Chengguang Zhao, Lehe Yang and Liangxing Wang
    Citation: Journal of Translational Medicine 2022 20:525
  3. Pulmonary fibrosis is a chronic progressive fibrotic interstitial lung disease characterized by excessive extracellular matrix (ECM) deposition caused by activated fibroblasts. Increasing evidence shows that m...

    Authors: Demin Cheng, Ziwei Li, Yue Wang, Haojie Xiong, Wenqing Sun, Siyun Zhou, Yi Liu and Chunhui Ni
    Citation: Journal of Translational Medicine 2022 20:523
  4. We reported that PARP-1 regulates genes whose products are crucial for asthma, in part, by controlling STAT6 integrity speculatively through a calpain-dependent mechanism. We wished to decipher the PARP-1/STAT...

    Authors: Jeffrey Wang, Mohamed A. Ghonim, Salome V. Ibba, Hanh H. Luu, Yucel Aydin, Peter A. Greer and A. Hamid Boulares
    Citation: Journal of Translational Medicine 2022 20:521
  5. Colorectal cancer (CRC) is one of the most commonly diagnosed human malignancies. Ribosomal protein L31 (RPL31, aka eL31) is a component of the 60S large ribosomal subunit, and its expression pattern and funct...

    Authors: Gaowa Sharen, Xiongfeng Li, Jiaxin Sun, Lei Zhang, Wen Xi, Xiaodong Zhao, Fei Han, Longlong Jia, Rong A, Haidong Cheng and Mingxing Hou
    Citation: Journal of Translational Medicine 2022 20:493
  6. Pancreatic adenocarcinoma (PAAD) is one of the most common malignant tumors of the digestive tract. Pyroptosis is a newly discovered programmed cell death that highly correlated with the prognosis of tumors. H...

    Authors: Cheng Yan, Yandie Niu, Feng Li, Wei Zhao and Liukai Ma
    Citation: Journal of Translational Medicine 2022 20:455
  7. Liver hepatocellular carcinoma (LIHC) ranks sixth among the most common types of cancer with a high mortality rate. Cuproptosis is a newly discovered type of cell death in tumor, which is characterized by accu...

    Authors: Cheng Yan, Yandie Niu, Liukai Ma, Lifang Tian and Jiahao Ma
    Citation: Journal of Translational Medicine 2022 20:452
  8. Gliomas account for about 80% of all malignant brain and other central nervous system (CNS) tumors. Temozolomide (TMZ) resistance represents a major treatment hurdle. Adrenomedullin (ADM) has been reported to ...

    Authors: Zongze He, Meixiong Cheng, Junting Hu, Lingtong Liu, Ping Liu, Longyi Chen, Deqian Cao and Jian Tang
    Citation: Journal of Translational Medicine 2022 20:443
  9. Colorectal cancer (CRC) is one of the most common malignancies and the patient survival rate remains unacceptably low. The anti-programmed cell death-1 (PD-1)/programmed cell death ligand 1 (PD-L1) antibody-ba...

    Authors: Lian-sheng Cheng, Yong-feng Cheng, Wen-ting Liu, Aolin Shen, Dayan Zhang, Tingjuan Xu, Wu Yin, Min Cheng, Xiaopeng Ma, Fengrong Wang, Qun Zhao, Xiaoli Zeng, Yan Zhang and Guodong Shen
    Citation: Journal of Translational Medicine 2022 20:415
  10. Nonalcoholic steatohepatitis (NASH) occupies a substantial proportion of chronic liver disease worldwide, of which pathogenesis needs further research. Recent studies have demonstrated the significant roles of...

    Authors: Boqiang Liu, Yuanshi Tian, Jing He, Qiuxia Gu, Binghan Jin, Hao Shen, Weiqi Li, Liang Shi, Hong Yu, Ge Shan and Xiujun Cai
    Citation: Journal of Translational Medicine 2022 20:393
  11. Castration-resistant prostate cancer (CRPC) is a major cause of recurrence and mortality among prostate cancer (PCa) patients. Myeloid-derived suppressor cells (MDSCs) regulate castration resistance in PCa. Pr...

    Authors: Feng Gao, Qiaoping Xu, Zhe Tang, Nan Zhang, Yasheng Huang, Zhongyi Li, Yuliang Dai, Qiqi Yu and Jingyu Zhu
    Citation: Journal of Translational Medicine 2022 20:346
  12. Endometrial cancer (EC) is the most common gynecological malignancy in developed countries. Efficacy of the bromodomain 4 (BRD4) inhibitor JQ1 has been reported for the treatment of various human cancers, but ...

    Authors: Yingxin Pang, Gaigai Bai, Jing Zhao, Xuan Wei, Rui Li, Jie Li, Shunxue Hu, Lu Peng, Peishu Liu and Hongluan Mao
    Citation: Journal of Translational Medicine 2022 20:336
  13. Effective treatment is needed for advanced, inoperable, or chemotherapy-resistant cervical cancer patients. Immunotherapy has become a new treatment modality for cervical cancer patients, and there is an urgen...

    Authors: Siyang Zhang, Han Wang, Jiao Liu, Tao Tao, Zhi Zeng and Min Wang
    Citation: Journal of Translational Medicine 2022 20:334
  14. Our previous study has identified a novel circRNA (circDIDO1) that is down-regulated in gastric cancer (GC) and significantly inhibits GC progression. The purpose of this study is to identify the molecular mec...

    Authors: Zhen Guo, Yu Zhang, Wenrong Xu, Xu Zhang and Jiajia Jiang
    Citation: Journal of Translational Medicine 2022 20:326
  15. Enolase is an essential enzyme in the process of glycolysis and has been implicated in cancer progression. Though dysregulation of ENOs has been reported in multiple cancers, their prognostic value and specifi...

    Authors: Zhengnan Huang, Yilin Yan, Tengjiao Wang, Zeyi Wang, Jinming Cai, Xiangqian Cao, Chenkai Yang, Fang Zhang, Gang Wu and Bing Shen
    Citation: Journal of Translational Medicine 2022 20:315
  16. Patients with triple-negative breast cancer (TNBC) are better responders to neoadjuvant chemotherapy; however, they are poor in the durability of response with decreased overall and progression-free survival.

    Authors: Zhao-ying Yang, Cheng-wei Jiang, Wen-long Zhang and Guang Sun
    Citation: Journal of Translational Medicine 2022 20:276
  17. Ovarian cancer (OC) is a major threat to women’s health. Mesenchymal stem cells (MSCs) are key regulators in cellular communication by secreting extracellular vesicles (EVs) that are involved in OC. This study...

    Authors: Xiaoying Wang, Lili Jiang and Qifang Liu
    Citation: Journal of Translational Medicine 2022 20:258
  18. Mutated and non-mutated genes interact to drive cancer growth and metastasis. While research has focused on understanding the impact of mutated genes on cancer biology, understanding non-mutated genes that are...

    Authors: Halema Al-Farsi, Iman Al-Azwani, Joel A. Malek, Lotfi Chouchane, Arash Rafii and Najeeb M. Halabi
    Citation: Journal of Translational Medicine 2022 20:244
  19. The Great Debate session at the 2021 Melanoma Bridge virtual congress (December 2–4) featured counterpoint views from experts on seven important issues in melanoma. The debates considered the use of adoptive c...

    Authors: Paolo A. Ascierto, Allison Betof Warner, Christian Blank, Corrado Caracò, Sandra Demaria, Jeffrey E. Gershenwald, Nikhil I. Khushalani, Georgina V. Long, Jason J. Luke, Janice M. Mehnert, Caroline Robert, Piotr Rutkowski, Hussein A. Tawbi, Iman Osman and Igor Puzanov
    Citation: Journal of Translational Medicine 2022 20:200
  20. In this study we aimed to investigate signaling pathways that drive therapy resistance in esophageal adenocarcinoma (EAC). Paraffin-embedded material was analyzed in two patient cohorts: (i) 236 EAC patients w...

    Authors: A. Creemers, A. P. van der Zalm, A. van de Stolpe, L. Holtzer, M. Stoffels, G. K. J. Hooijer, E. A. Ebbing, H. van Ooijen, A. G. C. van Brussel, E. M. G. Aussems-Custers, M. I. van Berge Henegouwen, M. C. C. M. Hulshof, J. J. G. H. M. Bergman, S. L. Meijer, M. F. Bijlsma and H. W. M. van Laarhoven
    Citation: Journal of Translational Medicine 2022 20:183
  21. Exosomes are microvesicles secreted by cells. They contain a variety of bioactive substances with important roles in intercellular communication. Circular RNA (circRNA), a type of nucleic acid molecule found i...

    Authors: Dong Ye, Mengdan Gong, Yongqin Deng, Shuai Fang, Yujie Cao, Yizhen Xiang and Zhisen Shen
    Citation: Journal of Translational Medicine 2022 20:161
  22. JAK1 and JAK2 have been implicated in fibrosis and cancer as a fibroblast-related marker; however, their role in liver fibrosis has not been elucidated. Here, we aim to determine the effect and underlying mech...

    Authors: Zhenghui Song, Xinhui Liu, Wan Zhang, Yue Luo, Hua Xiao, Yun Liu, Guanqi Dai, Jian Hong and Aimin Li
    Citation: Journal of Translational Medicine 2022 20:157
  23. Urokinase-type plasminogen activator receptor (uPAR) is an attractive target for the treatment of cancer, because it is expressed at low levels in healthy tissues but at high levels in malignant tumours. uPAR ...

    Authors: Bing-Tao Zhai, Huan Tian, Jing Sun, Jun-Bo Zou, Xiao-Fei Zhang, Jiang-Xue Cheng, Ya-Jun Shi, Yu Fan and Dong-Yan Guo
    Citation: Journal of Translational Medicine 2022 20:135
  24. Lenvatinib is a multitargeted tyrosine kinase inhibitor that is being tested in combination with immune checkpoint inhibitors to treat advanced gastric cancer; however, little data exists regarding the efficac...

    Authors: John D. Karalis, Lynn Y. Yoon, Suntrea T. G. Hammer, Changjin Hong, Min Zhu, Ibrahim Nassour, Michelle R. Ju, Shu Xiao, Esther C. Castro-Dubon, Deepak Agrawal, Jorge Suarez, Scott I. Reznik, John C. Mansour, Patricio M. Polanco, Adam C. Yopp, Herbert J. Zeh III…
    Citation: Journal of Translational Medicine 2022 20:116
  25. Gastric cancer (GC) is one of the most common malignancies, and an increasing number of studies have shown that its pathogenesis is regulated by various miRNAs. In this study, we investigated the role of miR-8...

    Authors: Shenshuo Gao, Zhikai Zhang, Xubin Wang, Yan Ma, Chensheng Li, Hongjun Liu, Changqing Jing, Leping Li and Xiaobo Guo
    Citation: Journal of Translational Medicine 2022 20:115
  26. Cardiovascular impairment contributes to increased mortality in preterm infants with chronic lung disease. Macitentan, an endothelin-1 receptor antagonist, has the potential to attenuate pulmonary and cardiova...

    Authors: Philipp Baumann, Francesco Greco, Susanne Wiegert, Sven Wellmann, Giovanni Pellegrini and Vincenzo Cannizzaro
    Citation: Journal of Translational Medicine 2022 20:77
  27. Glioblastoma is currently an incurable cancer. Genome-wide association studies have demonstrated that 41 genetic variants are associated with glioblastoma and may provide an option for drug development.

    Authors: Wei-Zhi Lin, Yen-Chun Liu, Meng-Chang Lee, Chi-Tun Tang, Gwo-Jang Wu, Yu-Tien Chang, Chi-Ming Chu and Chia-Yang Shiau
    Citation: Journal of Translational Medicine 2022 20:70
  28. Young patients with colorectal cancer (CRC) exhibit poor prognoses compared to older patients due to the difficulty in early diagnosis and treatment. However, the underlying molecular characteristics are still...

    Authors: Tae Won Kim, Hye Kyung Hong, Chung Lee, Sunmin Kim, Woo Yong Lee, Seong Hyeon Yun, Hee Cheol Kim, Jung Wook Huh, Yoon Ah Park, Je-Gun Joung, Woong-Yang Park and Yong Beom Cho
    Citation: Journal of Translational Medicine 2021 19:446
  29. The lectin galactoside-binding soluble 3 binding protein (LGALS3BP) is a secreted, hyperglycosylated protein expressed by the majority of human cells. It was first identified as cancer and metastasis associate...

    Authors: Emily Capone, Stefano Iacobelli and Gianluca Sala
    Citation: Journal of Translational Medicine 2021 19:405
  30. Poorly cohesive (PC) is a unique histologic subtype of gastric cancer (GC), with an increasing incidence in recent years. However, the molecular characteristics and therapeutic targets of PC GC are not yet wel...

    Authors: Yue Wang, Tao Shi, Xuan Wang, Jinwei Hu, Lixia Yu, Qin Liu, Nandie Wu, Baorui Liu and Jia Wei
    Citation: Journal of Translational Medicine 2021 19:401
  31. Recent studies have showed that IKBKE is overexpressed in several kinds of cancers and that IKBKE-knockdown inhibits tumor progression. In this article, we first verified that two glioblastoma cell lines, U87-...

    Authors: Xin Wang, Jie Lu, Jing Li, Yang Liu, Gaochao Guo and Qiang Huang
    Citation: Journal of Translational Medicine 2021 19:396
  32. Lung adenocarcinoma (LUAD) is a common subtype of lung cancer with high recurrence rate and fatality. Circ_0001361 has been recognized as key regulators in various malignancies, but its roles in LUAD remain am...

    Authors: Hong-Yu Shen, Liu-Xi Shi, Lin Wang, Le-Ping Fang, Wei Xu, Ju-Qing Xu, Bo-Qiang Fan and Wei-Fei Fan
    Citation: Journal of Translational Medicine 2021 19:389

    The Correction to this article has been published in Journal of Translational Medicine 2021 19:476

  33. Pancreatic cancer is one of the most serious digestive malignancies. At present, there is an extreme lack of effective strategies in clinical treatment. The purpose of this study is to identify key genes and p...

    Authors: Yueqin Feng, Yuguan Jiang and Fengjin Hao
    Citation: Journal of Translational Medicine 2021 19:373
  34. As an important part of tumor immunotherapy for adjunct, therapeutic tumor vaccines have been effective against multiple solid cancers, while their efficacy against lower grade glioma (LGG) remains undefined. ...

    Authors: Liguo Ye, Long Wang, Ji’an Yang, Ping Hu, Chunyu Zhang, Shi’ao Tong, Zhennan Liu and Daofeng Tian
    Citation: Journal of Translational Medicine 2021 19:352
  35. DNA damage response plays critical roles in tumor pathogenesis and radiotherapy resistance. Protein phosphorylation is a critical mechanism in regulation of DNA damage response; however, the key mediators for ...

    Authors: Jia Liu, Jingyi Li, Zhao Sun, Yangmiao Duan, Fengqin Wang, Guangwei Wei and Jing-Hua Yang
    Citation: Journal of Translational Medicine 2021 19:339
  36. In recent years, long non-coding RNAs (lncRNAs) have attracted much attention because of its regulatory role in occurrence and progression of tumors, including triple-negative breast cancer (TNBC). LncRNA PITP...

    Authors: Bolong Liu, Pingbo Yao, Feng Xiao, Jianjin Guo, Lianghui Wu and Yong Yang
    Citation: Journal of Translational Medicine 2021 19:333
  37. Reversible enzymatic methylation of mammalian mRNA is widespread and serves crucial regulatory functions, but little is known to what degree chemical alkylators mediate overlapping modifications and whether ce...

    Authors: Kristian Lied Wollen, Lars Hagen, Cathrine B. Vågbø, Renana Rabe, Tobias S. Iveland, Per Arne Aas, Animesh Sharma, Bjørnar Sporsheim, Hilde O. Erlandsen, Vuk Palibrk, Magnar Bjørås, Davi M. Fonseca, Nima Mosammaparast and Geir Slupphaug
    Citation: Journal of Translational Medicine 2021 19:287
  38. Improved understanding of tumor immunology has enabled the development of therapies that harness the immune system and prevent immune escape. Numerous clinical trials and real-world experience has provided evi...

    Authors: Paolo A. Ascierto, Carlo Bifulco, Fortunato Ciardiello, Sandra Demaria, Leisha A. Emens, Robert Ferris, Silvia C. Formenti, Jerome Galon, Samir N. Khleif, Tomas Kirchhoff, Jennifer McQuade, Kunle Odunsi, Akash Patnaik, Chrystal M. Paulos, Janis M. Taube, John Timmerman…
    Citation: Journal of Translational Medicine 2021 19:238