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Emerging Therapeutics

Section edited by Gennaro Ciliberto

© Parilov / stock.adobe.comThe Emerging Therapeutics section is dedicated to the wave of emerging therapeutics arising from the intense research efforts and therapeutic breakthroughs based on recent scientific and technological developments. 

The section is interested in original papers, reviews and perspectives on the advancements in the field, including genetic vaccines, monoclonal antibodies, CAR-Ts, gene therapy with viral vectors, clinical applications of CRISPR/CAS9 gene editing, microbiota-modulating approaches, ‘omics approaches, emerging therapeutics from the development of new technologies for drug development, and discovery of new intervention targets and the possibility for new drug combinations.

  1. The lectin galactoside-binding soluble 3 binding protein (LGALS3BP) is a secreted, hyperglycosylated protein expressed by the majority of human cells. It was first identified as cancer and metastasis associate...

    Authors: Emily Capone, Stefano Iacobelli and Gianluca Sala

    Citation: Journal of Translational Medicine 2021 19:405

    Content type: Review

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  2. Poorly cohesive (PC) is a unique histologic subtype of gastric cancer (GC), with an increasing incidence in recent years. However, the molecular characteristics and therapeutic targets of PC GC are not yet wel...

    Authors: Yue Wang, Tao Shi, Xuan Wang, Jinwei Hu, Lixia Yu, Qin Liu, Nandie Wu, Baorui Liu and Jia Wei

    Citation: Journal of Translational Medicine 2021 19:401

    Content type: Research

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  3. Recent studies have showed that IKBKE is overexpressed in several kinds of cancers and that IKBKE-knockdown inhibits tumor progression. In this article, we first verified that two glioblastoma cell lines, U87-...

    Authors: Xin Wang, Jie Lu, Jing Li, Yang Liu, Gaochao Guo and Qiang Huang

    Citation: Journal of Translational Medicine 2021 19:396

    Content type: Research

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  4. Lung adenocarcinoma (LUAD) is a common subtype of lung cancer with high recurrence rate and fatality. Circ_0001361 has been recognized as key regulators in various malignancies, but its roles in LUAD remain am...

    Authors: Hong-Yu Shen, Liu-Xi Shi, Lin Wang, Le-Ping Fang, Wei Xu, Ju-Qing Xu, Bo-Qiang Fan and Wei-Fei Fan

    Citation: Journal of Translational Medicine 2021 19:389

    Content type: Research

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  5. Pancreatic cancer is one of the most serious digestive malignancies. At present, there is an extreme lack of effective strategies in clinical treatment. The purpose of this study is to identify key genes and p...

    Authors: Yueqin Feng, Yuguan Jiang and Fengjin Hao

    Citation: Journal of Translational Medicine 2021 19:373

    Content type: Research

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  6. As an important part of tumor immunotherapy for adjunct, therapeutic tumor vaccines have been effective against multiple solid cancers, while their efficacy against lower grade glioma (LGG) remains undefined. ...

    Authors: Liguo Ye, Long Wang, Ji’an Yang, Ping Hu, Chunyu Zhang, Shi’ao Tong, Zhennan Liu and Daofeng Tian

    Citation: Journal of Translational Medicine 2021 19:352

    Content type: Research

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  7. DNA damage response plays critical roles in tumor pathogenesis and radiotherapy resistance. Protein phosphorylation is a critical mechanism in regulation of DNA damage response; however, the key mediators for ...

    Authors: Jia Liu, Jingyi Li, Zhao Sun, Yangmiao Duan, Fengqin Wang, Guangwei Wei and Jing-Hua Yang

    Citation: Journal of Translational Medicine 2021 19:339

    Content type: Research

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  8. In recent years, long non-coding RNAs (lncRNAs) have attracted much attention because of its regulatory role in occurrence and progression of tumors, including triple-negative breast cancer (TNBC). LncRNA PITP...

    Authors: Bolong Liu, Pingbo Yao, Feng Xiao, Jianjin Guo, Lianghui Wu and Yong Yang

    Citation: Journal of Translational Medicine 2021 19:333

    Content type: Research

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  9. Reversible enzymatic methylation of mammalian mRNA is widespread and serves crucial regulatory functions, but little is known to what degree chemical alkylators mediate overlapping modifications and whether ce...

    Authors: Kristian Lied Wollen, Lars Hagen, Cathrine B. Vågbø, Renana Rabe, Tobias S. Iveland, Per Arne Aas, Animesh Sharma, Bjørnar Sporsheim, Hilde O. Erlandsen, Vuk Palibrk, Magnar Bjørås, Davi M. Fonseca, Nima Mosammaparast and Geir Slupphaug

    Citation: Journal of Translational Medicine 2021 19:287

    Content type: Research

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  10. Improved understanding of tumor immunology has enabled the development of therapies that harness the immune system and prevent immune escape. Numerous clinical trials and real-world experience has provided evi...

    Authors: Paolo A. Ascierto, Carlo Bifulco, Fortunato Ciardiello, Sandra Demaria, Leisha A. Emens, Robert Ferris, Silvia C. Formenti, Jerome Galon, Samir N. Khleif, Tomas Kirchhoff, Jennifer McQuade, Kunle Odunsi, Akash Patnaik, Chrystal M. Paulos, Janis M. Taube, John Timmerman…

    Citation: Journal of Translational Medicine 2021 19:238

    Content type: Meeting report

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