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Pain, Critical Care and Anesthesia

Section edited by Yasin S. Al Makadma and Ahmed Labib

Pain, Critical Care and Anesthesia section encompasses three major fields that are often tightly inter-related both historically and in everyday practice. A systematic Translational Medical approach may be our best route towards analysing common links and complete some of our limited understanding of common clinical pictures. Our section will also contribute in the understanding of mechanistic aspect of different anaesthetic agents and molecules and attempt to deepen the insight in the role of pharmacogenetics.

For that to happen, this section welcomes a very wide range of original research and review articles in related areas.

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  1. No direct approach assessing pulmonary vascular permeability exists in the current therapeutic strategy for patients with acute respiratory distress syndrome (ARDS). Transpulmonary thermodilution measures hemo...

    Authors: Yusuke Endo, Taku Miyasho, Kanako Endo, Yoshio Kawamura, Kenjiro Miyoshi, Ryosuke Takegawa, Takashi Tagami, Lance B. Becker and Kei Hayashida
    Citation: Journal of Translational Medicine 2022 20:617
    Content type: Research Published on:

  2. Growing evidence shows that C-Type Lectin Domain Containing 7A (Clec7a) may be involved into neuroinflammatory injury of various neurological diseases. However, its roles in neuropathic pain remain unclear.

    Authors: Dan Wu, Yanqiong Zhang, Chunhui Zhao, Qiuyue Li, Junhong Zhang, Jiaxin Han, Zhijian Xu, Junfang Li, Yan Ma, Ping Wang and Haiyu Xu
    Citation: Journal of Translational Medicine 2022 20:583
    Content type: Research Published on:

  3. Acute lung injury (ALI) occurs in 23% unilateral. Models of unilateral ALI were developed and used previously without clearly demonstrating the strictly unilateral nature and severity of lung injury by the key...

    Authors: Johannes Geilen, Matthias Kainz, Bernhard Zapletal, Silvana Geleff, Wilfried Wisser, Barbara Bohle, Thomas Schweiger, Marcus J. Schultz and Edda Tschernko
    Citation: Journal of Translational Medicine 2022 20:548
    Content type: Research Published on:

  4. Extracorporeal blood purification therapies targeting removal of the downstream products of the inflammatory cascade in sepsis have failed to improve mortality. As an upstream process of the inflammatory casca...

    Authors: Lei Zhou, Dong Zhang, Ling Kong, Xiaodong Xu and Dehua Gong
    Citation: Journal of Translational Medicine 2022 20:538
    Content type: Research Published on:

  5. Transcatheter arterial embolization (TAE) is one of the first-line treatments for advanced hepatocellular cancer. The pain caused by TAE is a stark complication, which remains to be prevented by biomedical eng...

    Authors: Chuan Tian, Zijian Wang, Lei Huang, Yimin Liu, Kunpeng Wu, Zhaonan Li, Bin Han, Dechao Jiao, Xinwei Han and Yanan Zhao
    Citation: Journal of Translational Medicine 2022 20:463
    Content type: Research Published on:

  6. Only a small number of patients survive an out-of-hospital cardiac arrest (CA) and can be discharged from hospital alive with a large percentage of these patients retaining neurological impairments. In recent ...

    Authors: Patrick Bernhard, Berit Amelie Bretthauer, Sam Joé Brixius, Hannah Bügener, Johannes Elias Groh, Christian Scherer, Domagoj Damjanovic, Jörg Haberstroh, Georg Trummer, Christoph Benk, Friedhelm Beyersdorf, Oliver Schilling and Jan-Steffen Pooth
    Citation: Journal of Translational Medicine 2022 20:238
    Content type: Research Published on:

  7. Acute kidney injury (AKI) is associated with high morbidity and mortality. Multiple urinary biomarkers have been identified to be associated with the prediction of AKI and outcomes. However, the accuracy of th...

    Authors: Hui Huang, Qiang Lin, Xiaomei Dai, Jiao Chen, Zhenjiang Bai, Xiaozhong Li, Fang Fang and Yanhong Li
    Citation: Journal of Translational Medicine 2022 20:102
    Content type: Research Published on:

  8. Sepsis-associated acute kidney injury (S-AKI) is a common and life-threatening complication in hospitalized and critically ill patients. This condition is an independent cause of death. This study was performe...

    Authors: Luming Zhang, Fengshuo Xu, Didi Han, Tao Huang, Shaojin Li, Haiyan Yin and Jun Lyu
    Citation: Journal of Translational Medicine 2021 19:518
    Content type: Research Published on:

  9. Despite the benefits of extracorporeal cardiopulmonary resuscitation (ECPR) in cohorts of selected patients with cardiac arrest (CA), extracorporeal membrane oxygenation (ECMO) includes an artificial oxygenati...

    Authors: Tai Yin, Lance B. Becker, Rishabh C. Choudhary, Ryosuke Takegawa, Muhammad Shoaib, Koichiro Shinozaki, Yusuke Endo, Koichiro Homma, Daniel M. Rolston, Shuhei Eguchi, Tadashi Ariyoshi, Asami Matsumoto, Kentaro Oka, Motomichi Takahashi, Tomoaki Aoki, Santiago J. Miyara…
    Citation: Journal of Translational Medicine 2021 19:462
    Content type: Research Published on:

  10. Despite much evidence supporting the monitoring of the divergence of transcutaneous partial pressure of carbon dioxide (tcPCO2) from arterial partial pressure carbon dioxide (artPCO2) as an indicator of the shock...

    Authors: Yusuke Endo, Taku Hirokawa, Taku Miyasho, Ryosuke Takegawa, Koichiro Shinozaki, Daniel M. Rolston, Lance B. Becker and Kei Hayashida
    Citation: Journal of Translational Medicine 2021 19:390
    Content type: Research Published on:

  11. Induction of long-term synaptic depression (LTD) is proposed as a treatment mechanism for chronic pain but remains untested in clinical populations. Two interlinked studies; (1) A patient-assessor blinded, ran...

    Authors: Selina Johnson, Anne Marshall, Dyfrig Hughes, Emily Holmes, Florian Henrich, Turo Nurmikko, Manohar Sharma, Bernhard Frank, Paul Bassett, Andrew Marshall, Walter Magerl and Andreas Goebel
    Citation: Journal of Translational Medicine 2021 19:458
    Content type: Research Published on:

  12. A growing body of evidence suggests that transcutaneous auricular vagus nerve stimulation (taVNS) may relieve symptoms of migraineurs. Frequency is one of the key stimulation parameters. The aim of this study ...

    Authors: Jin Cao, Yue Zhang, Hui Li, Zhaoxian Yan, Xian Liu, Xiaoyan Hou, Weicui Chen, Sierra Hodges, Jian Kong and Bo Liu
    Citation: Journal of Translational Medicine 2021 19:354
    Content type: Research Published on:

  13. To examine the effects of BI 1029539 (GS-248), a novel selective human microsomal prostaglandin E synthase-1 (mPGES-1) inhibitor, in experimental models of acute lung injury (ALI) and sepsis in transgenic mice co...

    Authors: Malarvizhi Gurusamy, Saeed Nasseri, Dileep Reddy Rampa, Huiying Feng, Dongwon Lee, Anton Pekcec, Henri Doods and Dongmei Wu
    Citation: Journal of Translational Medicine 2021 19:340
    Content type: Research Published on:

  14. Early and accurate identification of septic patients at high risk for ICU mortality can help clinicians make optimal clinical decisions and improve the patients’ outcomes. This study aimed to develop and valid...

    Authors: Jie Weng, Ruonan Hou, Xiaoming Zhou, Zhe Xu, Zhiliang Zhou, Peng Wang, Liang Wang, Chan Chen, Jinyu Wu and Zhiyi Wang
    Citation: Journal of Translational Medicine 2021 19:322
    Content type: Research Published on:

  15. Extracorporeal membrane oxygenation (ECMO) research using large animals requires a significant amount of resources, slowing down the development of new means of ECMO anticoagulation. Therefore, this study deve...

    Authors: Nao Umei, Angela Lai, Jennifer Miller, Suji Shin, Kalliope Roberts, Saif AI Qatarneh, Shingo Ichiba, Atsuhiro Sakamoto and Keith E. Cook
    Citation: Journal of Translational Medicine 2021 19:179
    Content type: Methodology Published on:

  17. Migraine and depression are highly prevalent and partly overlapping disorders that cause strong limitations in daily life. Patients tend to respond poorly to the therapies available for these diseases. Onabotu...

    Authors: Oreste Affatato, Thiago C. Moulin, Claudia Pisanu, Victoria S. Babasieva, Marco Russo, Elif I. Aydinlar, Paola Torelli, Vladimir N. Chubarev, Vadim V. Tarasov, Helgi B. Schiöth and Jessica Mwinyi
    Citation: Journal of Translational Medicine 2021 19:133
    Content type: Review Published on:

  18. Midkine is a multi-functional molecule participating in a various key pathological process. We aimed to evaluate the change of midkine in sepsis and its association with angiotensin-converting enzyme (ACE) sys...

    Authors: Jing-Yuan Xu, Wei Chang, Qin Sun, Fei Peng and Yi Yang
    Citation: Journal of Translational Medicine 2021 19:91
    Content type: Research Published on:

  19. The functional residual capacity (FRC) determines the oxygenating capacity of the lung and is heavily affected in the clinical context of the acute respiratory distress syndrome. Nitrogen-wash-in/wash-out meth...

    Authors: Joana Berger-Estilita, Matthias Haenggi, Daniel Ott and David Berger
    Citation: Journal of Translational Medicine 2021 19:36
    Content type: Research Published on:

  20. Treating severe forms of the acute respiratory distress syndrome and cardiac failure, extracorporeal membrane oxygenation (ECMO) has become an established therapeutic option. Neonatal or pediatric patients rec...

    Authors: Malte Schöps, Sascha H. Groß-Hardt, Thomas Schmitz-Rode, Ulrich Steinseifer, Daniel Brodie, Johanna C. Clauser and Christian Karagiannidis
    Citation: Journal of Translational Medicine 2021 19:2
    Content type: Research Published on:

  21. Healthcare-associated pneumonia (HCAP) is a heterogeneous disease. We redefined nursing-home- and hospital-associated infections (NHAI) group by revising existing HCAP risk factors. The NHAI group comprised nu...

    Authors: Min-gyung Baek, Seong Ji Woo, Nam Eun Kim, Chaeyun Baek, Sungho Won, Youngmi Kim, Jae Jun Lee, Hana Yi and Ji Young Hong
    Citation: Journal of Translational Medicine 2020 18:464
    Content type: Research Published on:

  22. Sepsis is a significant cause of mortality in-hospital, especially in ICU patients. Early prediction of sepsis is essential, as prompt and appropriate treatment can improve survival outcomes. Machine learning ...

    Authors: Nianzong Hou, Mingzhe Li, Lu He, Bing Xie, Lin Wang, Rumin Zhang, Yong Yu, Xiaodong Sun, Zhengsheng Pan and Kai Wang
    Citation: Journal of Translational Medicine 2020 18:462
    Content type: Research Published on:

  23. In a previous study, we reported that selective dorsal root ganglion stimulation (DRGSTIM) at DRG level L4 promoted a favorable outcome for complex regional pain syndrome (CRPS) patients along with DRGSTIM-relate...

    Authors: Thomas Kinfe, Nico von Willebrand, Andreas Stadlbauer, Michael Buchfelder, Thomas L. Yearwood, Sajjad Muhammad, Shafqat R. Chaudhry, Sascha Gravius, Thomas Randau, Klemens Winder, Christian Maihöfner, Nadine Gravius and Walter Magerl
    Citation: Journal of Translational Medicine 2020 18:403
    Content type: Research Published on:

  24. Sepsis is a leading cause of mortality and morbidity in the intensive care unit. Regulatory mechanisms underlying the disease progression and prognosis are largely unknown. The study aimed to identify master r...

    Authors: Zhongheng Zhang, Lin Chen, Ping Xu, Lifeng Xing, Yucai Hong and Pengpeng Chen
    Citation: Journal of Translational Medicine 2020 18:381
    Content type: Research Published on:

  25. Lung ischemia–reperfusion injury (LIRI) is a complex pathophysiological process that can lead to poor patient outcomes. Inflammasome-dependent macrophage pyroptosis contributes to organ damage caused by ischem...

    Authors: Lin Fei, Xiao Jingyuan, Liang Fangte, Dai Huijun, Ye Liu, Jing Ren, Lin Jinyuan and Pan Linghui
    Citation: Journal of Translational Medicine 2020 18:301
    Content type: Research Published on:

  26. Previous research has focused on intensive care unit (ICU)-acquired hypernatremia; however, ICU-acquired hyponatremia has frequently been overlooked and has rarely been studied in surgical or mixed ICUs. The a...

    Authors: Jae Kyeom Sim, Ryoung-Eun Ko, Soo Jin Na, Gee Young Suh and Kyeongman Jeon
    Citation: Journal of Translational Medicine 2020 18:268
    Content type: Research Published on:

  27. Extracorporeal membrane oxygenation (ECMO) is increasingly used in intensive care units and can modify drug pharmacokinetics and lead to under-exposure associated with treatment failure. Ceftolozane/tazobactam...

    Authors: Camille Mané, Clément Delmas, Jean Porterie, Géraldine Jourdan, Patrick Verwaerde, Bertrand Marcheix, Didier Concordet, Bernard Georges, Stéphanie Ruiz and Peggy Gandia
    Citation: Journal of Translational Medicine 2020 18:213
    Content type: Research Published on:

  28. In sepsis, the endothelial barrier becomes incompetent, with the leaking of plasma into interstitial tissues. VE-cadherin, an adherens junction protein, is the gatekeeper of endothelial cohesion. Kinins, relea...

    Authors: Stéphanie Ruiz, Fanny Vardon-Bounes, Marie Buléon, Céline Guilbeau-Frugier, Marie-Hélène Séguelas, Jean-Marie Conil, Jean-Pierre Girolami, Ivan Tack and Vincent Minville
    Citation: Journal of Translational Medicine 2020 18:174
    Content type: Research Published on:

  29. Sphingosine-1-phosphate (S1P) is a signaling phospholipid involved in pathophysiologic progression of acute respiratory distress syndrome (ARDS) through its roles in endothelial barrier function and immune mod...

    Authors: Jiangnan Zhao, Yan Tan, Li Wang, Xin Su and Yi Shi
    Citation: Journal of Translational Medicine 2020 18:156
    Content type: Research Published on:

  30. We have reported that polydatin (PD) alleviates mitochondrial dysfunction in rat models of sepsis-induced acute kidney injury (SI-AKI), but the mechanism is not well understood. Here, we investigated the role ...

    Authors: Youguang Gao, Xingui Dai, Yunfeng Li, Guicheng Li, Xianzhong Lin, Chenmu Ai, Yuanyuan Cao, Tao Li and Bo Lin
    Citation: Journal of Translational Medicine 2020 18:114
    Content type: Research Published on:

  31. An impedance threshold device (ITD) was developed to increase venous return to the heart and therefore increase cardiac output and organ blood flow during cardiopulmonary rescue (CPR). Basic CPR aims to mainta...

    Authors: Benedict Kjaergaard, Hans O. Holdgaard, Sigridur O. Magnusdottir, Søren Lundbye-Christensen and Erika F. Christensen
    Citation: Journal of Translational Medicine 2020 18:83
    Content type: Research Published on:

  32. Despite goal-directed hemodynamic therapy, vascular function may deteriorate during surgery for advanced abdominal tumor masses. Fluid administration has been shown to be associated with distinct changes in se...

    Authors: Jennifer Gehlen, Sven Klaschik, Claudia Neumann, Mignon-Denise Keyver-Paik, Alexander Mustea, Martin Soehle, Stilla Frede, Markus Velten, Andreas Hoeft and Tobias Hilbert
    Citation: Journal of Translational Medicine 2020 18:48
    Content type: Research Published on:

  33. Pain is the vital sense preventing tissue damage by harmful noxious stimuli. The capsaicin receptor TRPV1 is activated by noxious temperatures, however, acute heat pain is only marginally affected in mice afte...

    Authors: Daniela C. Rosenberger, Uta Binzen, Rolf-Detlef Treede and Wolfgang Greffrath
    Citation: Journal of Translational Medicine 2020 18:28
    Content type: Research Published on:

  34. Tibial fracture is associated with inflammatory reaction leading to severe pain syndrome. Bradykinin receptor activation is involved in inflammatory reactions, but has never been investigated in fracture pain.

    Authors: Vincent Minville, Lionel Mouledous, Acil Jaafar, Réjean Couture, Anne Brouchet, Bernard Frances, Ivan Tack and Jean-Pierre Girolami
    Citation: Journal of Translational Medicine 2019 17:346
    Content type: Research Published on:

  35. Despite advances in clinical management, there are currently no novel therapeutic targets for acute respiratory distress syndrome (ARDS). DNA methylation, as a reversible process involved in the development an...

    Authors: Shi Zhang, Zongsheng Wu, Jianfeng Xie, Yi Yang, Lei Wang and Haibo Qiu
    Citation: Journal of Translational Medicine 2019 17:345
    Content type: Research Published on:

  36. To develop a machine learning model for predicting acute respiratory distress syndrome (ARDS) events through commonly available parameters, including baseline characteristics and clinical and laboratory parame...

    Authors: Xian-Fei Ding, Jin-Bo Li, Huo-Yan Liang, Zong-Yu Wang, Ting-Ting Jiao, Zhuang Liu, Liang Yi, Wei-Shuai Bian, Shu-Peng Wang, Xi Zhu and Tong-Wen Sun
    Citation: Journal of Translational Medicine 2019 17:326
    Content type: Research Published on:

  37. Experimental studies suggest that testosterone reduces the nociceptive response after inflammatory and neuropathic stimuli, however the underlying mechanisms have not been fully elucidated. The aims of this st...

    Authors: José Osvaldo Barbosa Neto, João Batista Santos Garcia, Maria do Socorro de Souza Cartágenes, Andressa Godoy Amaral, Luiz Fernando Onuchic and Hazem Adel Ashmawi
    Citation: Journal of Translational Medicine 2019 17:287
    Content type: Research Published on:

  38. In our recent clinical trial, increased peripheral concentrations of pro-inflammatory molecular mediators were determined in complex regional pain syndrome (CRPS) patients. After 3 months adjunctive unilateral...

    Authors: Thomas M. Kinfe, Maria Asif, Krishnan V. Chakravarthy, Timothy R. Deer, Jeffery M. Kramer, Thomas L. Yearwood, Rene Hurlemann, Muhammad Sajid Hussain, Susanne Motameny, Prerana Wagle, Peter Nürnberg, Sascha Gravius, Thomas Randau, Nadine Gravius, Shafqat R. Chaudhry and Sajjad Muhammad
    Citation: Journal of Translational Medicine 2019 17:205
    Content type: Research Published on:

  39. Fibroblast growth factor 23 (FGF23) and endothelium-related biomarkers have been related to AKI in critically-ill patients. Also, FGF23 is associated with endothelial dysfunction. In this study, we investigate...

    Authors: Fernanda Macedo de Oliveira Neves, Camila Barbosa Araújo, Daniele Ferreira de Freitas, Bianca Fernandes Távora Arruda, Leonardo José Monteiro de Macêdo Filho, Vivian Brito Salles, Gdayllon Cavalcante Meneses, Alice Maria Costa Martins and Alexandre Braga Libório
    Citation: Journal of Translational Medicine 2019 17:121
    Content type: Research Published on:

  40. Therapeutic plasma exchange (PE) or plasmapheresis is an extracorporeal procedure employed to treat immunological disorders. Exosomes, nanosized vesicles of endosomal origin, mediate intercellular communicatio...

    Authors: Sujay Ramanathan, Sabrina R. Douglas, Guillermo M. Alexander, Botros B. Shenoda, James E. Barrett, Enrique Aradillas, Ahmet Sacan and Seena K. Ajit
    Citation: Journal of Translational Medicine 2019 17:81
    Content type: Research Published on:

  41. T helper (Th) cells regulate sepsis processes, including primary pathogen clear and secondary pathogen defence. The objectives of this study were to determine the early and dynamic alterations of Th1 and Th2 p...

    Authors: Ming Xue, Jianfeng Xie, Ling Liu, Yingzi Huang, Fengmei Guo, Jingyuan Xu, Yi Yang and Haibo Qiu
    Citation: Journal of Translational Medicine 2019 17:57
    Content type: Research Published on:

  42. Rising evidence indicate that oxytocin and IL-1β impact trigemino-nociceptive signaling. Current perspectives on migraine physiopathology emphasize a cytokine bias towards a pro-inflammatory status. The anti-n...

    Authors: Azize Boström, Dirk Scheele, Birgit Stoffel-Wagner, Frigga Hönig, Shafqat R. Chaudhry, Sajjad Muhammad, Rene Hurlemann, Joachim K. Krauss, Ilana S. Lendvai, Krishnan V. Chakravarthy and Thomas M. Kinfe
    Citation: Journal of Translational Medicine 2019 17:53
    Content type: Research Published on:

  43. Dexmedetomidine (DEX) has been reported to promote tumour metastases. However the underlying mechanisms remain unclear. The purpose of this study was to investigate whether DEX promotes tumour metastasis by in...

    Authors: Xiaosan Su, Yaodong Fan, Liu Yang, Jie Huang, Fei Qiao, Yu Fang and Jun Wang
    Citation: Journal of Translational Medicine 2018 16:347
    Content type: Research Published on:

  44. The ProCESS, ARISE, and ProMISe trials have failed to show that early goal-directed therapy (EGDT) reduces mortality in patients with severe sepsis and septic shock. Although lactate-guided therapy (LGT) has b...

    Authors: Xian-Fei Ding, Zi-Yue Yang, Zhen-Tao Xu, Li-Feng Li, Bo Yuan, Li-Na Guo, Le-Xin Wang, Xi Zhu and Tong-Wen Sun
    Citation: Journal of Translational Medicine 2018 16:331
    Content type: Research Published on:

  45. Widespread use of antibiotics in the intensive care unit is a potential cause of the emergence of hospital-acquired pneumonia. This study determined whether Lactobacillus salivarius feeding could reverse antibiot...

    Authors: Tzyy-Bin Tsay, Ming-Chieh Yang, Wan-Hsuan Chang, Pei-Hsuan Chen and Lee-Wei Chen
    Citation: Journal of Translational Medicine 2018 16:225
    Content type: Research Published on:

  46. Dexmedetomidine (Dex) can improve neuronal viability and protect the spinal cord from ischemia–reperfusion (I/R) injury, but the underlying mechanisms are not fully understood. This study investigated the effe...

    Authors: Zhixiang Sun, Tianyun Zhao, Shaojun Lv, Ying Gao, Joe Masters and Hao Weng
    Citation: Journal of Translational Medicine 2018 16:209
    Content type: Research Published on:

  47. It has been shown that severe insult to the immune system may trigger prolonged macrophage characteristics associated with excessive release of monocyte colony stimulating factor (M-CSF). However, it is unclea...

    Authors: Krzysztof Laudanski, Mateusz Zawadka, Jacek Polosak, Jaymin Modi, Matthew DiMeglio, Jacob Gutsche, Wilson Y. Szeto and Monika Puzianowska-Kuznicka
    Citation: Journal of Translational Medicine 2018 16:143
    Content type: Research Published on:

  48. Acute lung injury caused by renal ischemia–reperfusion is one of the leading causes of acute kidney injury-related death. Dexmedetomidine, an α2-adrenergic agonist sedative, has been found to have protective effe...

    Authors: Juanjuan Li, Qian Chen, Xinhai He, Azeem Alam, Jiaolin Ning, Bin Yi, Kaizhi Lu and Jianteng Gu
    Citation: Journal of Translational Medicine 2018 16:78
    Content type: Research Published on:

  49. Septic shock is a major cause of death in intensive care units around the world . The aim of the study was to investigate whether the novel drug R-100 (a superoxide degradation catalyst and nitric oxide donor)...

    Authors: Hiroshi Ito, Erik Malgerud, Sven Asmussen, Ernesto Lopez, Andrew L. Salzman and Perenlei Enkhbaatar
    Citation: Journal of Translational Medicine 2017 15:266
    Content type: Research Published on:

  50. Acute heart failure (AHF) is a frequent reason for hospitalization worldwide and effective treatment options are limited. It is known that AHF is a condition characterized by impaired vasorelaxation, together ...

    Authors: Roman Falls, Michael Seman, Sabine Braat, Joshua Sortino, Jason D. Allen and Christopher J. Neil
    Citation: Journal of Translational Medicine 2017 15:172
    Content type: Protocol Published on:
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