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Pain, Critical Care and Anesthesia

Section edited by Yasin S. Al Makadma and Ahmed Labib

Pain, Critical Care and Anesthesia section encompasses three major fields that are often tightly inter-related both historically and in everyday practice. A systematic Translational Medical approach may be our best route towards analysing common links and complete some of our limited understanding of common clinical pictures. Our section will also contribute in the understanding of mechanistic aspect of different anaesthetic agents and molecules and attempt to deepen the insight in the role of pharmacogenetics.

For that to happen, this section welcomes a very wide range of original research and review articles in related areas.

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  1. Despite the benefits of extracorporeal cardiopulmonary resuscitation (ECPR) in cohorts of selected patients with cardiac arrest (CA), extracorporeal membrane oxygenation (ECMO) includes an artificial oxygenati...

    Authors: Tai Yin, Lance B. Becker, Rishabh C. Choudhary, Ryosuke Takegawa, Muhammad Shoaib, Koichiro Shinozaki, Yusuke Endo, Koichiro Homma, Daniel M. Rolston, Shuhei Eguchi, Tadashi Ariyoshi, Asami Matsumoto, Kentaro Oka, Motomichi Takahashi, Tomoaki Aoki, Santiago J. Miyara…

    Citation: Journal of Translational Medicine 2021 19:462

    Content type: Research

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  2. Despite much evidence supporting the monitoring of the divergence of transcutaneous partial pressure of carbon dioxide (tcPCO2) from arterial partial pressure carbon dioxide (artPCO2) as an indicator of the shock...

    Authors: Yusuke Endo, Taku Hirokawa, Taku Miyasho, Ryosuke Takegawa, Koichiro Shinozaki, Daniel M. Rolston, Lance B. Becker and Kei Hayashida

    Citation: Journal of Translational Medicine 2021 19:390

    Content type: Research

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  3. Induction of long-term synaptic depression (LTD) is proposed as a treatment mechanism for chronic pain but remains untested in clinical populations. Two interlinked studies; (1) A patient-assessor blinded, ran...

    Authors: Selina Johnson, Anne Marshall, Dyfrig Hughes, Emily Holmes, Florian Henrich, Turo Nurmikko, Manohar Sharma, Bernhard Frank, Paul Bassett, Andrew Marshall, Walter Magerl and Andreas Goebel

    Citation: Journal of Translational Medicine 2021 19:458

    Content type: Research

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  4. A growing body of evidence suggests that transcutaneous auricular vagus nerve stimulation (taVNS) may relieve symptoms of migraineurs. Frequency is one of the key stimulation parameters. The aim of this study ...

    Authors: Jin Cao, Yue Zhang, Hui Li, Zhaoxian Yan, Xian Liu, Xiaoyan Hou, Weicui Chen, Sierra Hodges, Jian Kong and Bo Liu

    Citation: Journal of Translational Medicine 2021 19:354

    Content type: Research

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  5. To examine the effects of BI 1029539 (GS-248), a novel selective human microsomal prostaglandin E synthase-1 (mPGES-1) inhibitor, in experimental models of acute lung injury (ALI) and sepsis in transgenic mice co...

    Authors: Malarvizhi Gurusamy, Saeed Nasseri, Dileep Reddy Rampa, Huiying Feng, Dongwon Lee, Anton Pekcec, Henri Doods and Dongmei Wu

    Citation: Journal of Translational Medicine 2021 19:340

    Content type: Research

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  6. Early and accurate identification of septic patients at high risk for ICU mortality can help clinicians make optimal clinical decisions and improve the patients’ outcomes. This study aimed to develop and valid...

    Authors: Jie Weng, Ruonan Hou, Xiaoming Zhou, Zhe Xu, Zhiliang Zhou, Peng Wang, Liang Wang, Chan Chen, Jinyu Wu and Zhiyi Wang

    Citation: Journal of Translational Medicine 2021 19:322

    Content type: Research

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  7. Extracorporeal membrane oxygenation (ECMO) research using large animals requires a significant amount of resources, slowing down the development of new means of ECMO anticoagulation. Therefore, this study deve...

    Authors: Nao Umei, Angela Lai, Jennifer Miller, Suji Shin, Kalliope Roberts, Saif AI Qatarneh, Shingo Ichiba, Atsuhiro Sakamoto and Keith E. Cook

    Citation: Journal of Translational Medicine 2021 19:179

    Content type: Methodology

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  8. Migraine and depression are highly prevalent and partly overlapping disorders that cause strong limitations in daily life. Patients tend to respond poorly to the therapies available for these diseases. Onabotu...

    Authors: Oreste Affatato, Thiago C. Moulin, Claudia Pisanu, Victoria S. Babasieva, Marco Russo, Elif I. Aydinlar, Paola Torelli, Vladimir N. Chubarev, Vadim V. Tarasov, Helgi B. Schiöth and Jessica Mwinyi

    Citation: Journal of Translational Medicine 2021 19:133

    Content type: Review

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  9. Midkine is a multi-functional molecule participating in a various key pathological process. We aimed to evaluate the change of midkine in sepsis and its association with angiotensin-converting enzyme (ACE) sys...

    Authors: Jing-Yuan Xu, Wei Chang, Qin Sun, Fei Peng and Yi Yang

    Citation: Journal of Translational Medicine 2021 19:91

    Content type: Research

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  10. The functional residual capacity (FRC) determines the oxygenating capacity of the lung and is heavily affected in the clinical context of the acute respiratory distress syndrome. Nitrogen-wash-in/wash-out meth...

    Authors: Joana Berger-Estilita, Matthias Haenggi, Daniel Ott and David Berger

    Citation: Journal of Translational Medicine 2021 19:36

    Content type: Research

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  11. Treating severe forms of the acute respiratory distress syndrome and cardiac failure, extracorporeal membrane oxygenation (ECMO) has become an established therapeutic option. Neonatal or pediatric patients rec...

    Authors: Malte Schöps, Sascha H. Groß-Hardt, Thomas Schmitz-Rode, Ulrich Steinseifer, Daniel Brodie, Johanna C. Clauser and Christian Karagiannidis

    Citation: Journal of Translational Medicine 2021 19:2

    Content type: Research

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  12. Healthcare-associated pneumonia (HCAP) is a heterogeneous disease. We redefined nursing-home- and hospital-associated infections (NHAI) group by revising existing HCAP risk factors. The NHAI group comprised nu...

    Authors: Min-gyung Baek, Seong Ji Woo, Nam Eun Kim, Chaeyun Baek, Sungho Won, Youngmi Kim, Jae Jun Lee, Hana Yi and Ji Young Hong

    Citation: Journal of Translational Medicine 2020 18:464

    Content type: Research

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  13. Sepsis is a significant cause of mortality in-hospital, especially in ICU patients. Early prediction of sepsis is essential, as prompt and appropriate treatment can improve survival outcomes. Machine learning ...

    Authors: Nianzong Hou, Mingzhe Li, Lu He, Bing Xie, Lin Wang, Rumin Zhang, Yong Yu, Xiaodong Sun, Zhengsheng Pan and Kai Wang

    Citation: Journal of Translational Medicine 2020 18:462

    Content type: Research

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  14. In a previous study, we reported that selective dorsal root ganglion stimulation (DRGSTIM) at DRG level L4 promoted a favorable outcome for complex regional pain syndrome (CRPS) patients along with DRGSTIM-relate...

    Authors: Thomas Kinfe, Nico von Willebrand, Andreas Stadlbauer, Michael Buchfelder, Thomas L. Yearwood, Sajjad Muhammad, Shafqat R. Chaudhry, Sascha Gravius, Thomas Randau, Klemens Winder, Christian Maihöfner, Nadine Gravius and Walter Magerl

    Citation: Journal of Translational Medicine 2020 18:403

    Content type: Research

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  15. Sepsis is a leading cause of mortality and morbidity in the intensive care unit. Regulatory mechanisms underlying the disease progression and prognosis are largely unknown. The study aimed to identify master r...

    Authors: Zhongheng Zhang, Lin Chen, Ping Xu, Lifeng Xing, Yucai Hong and Pengpeng Chen

    Citation: Journal of Translational Medicine 2020 18:381

    Content type: Research

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  16. Lung ischemia–reperfusion injury (LIRI) is a complex pathophysiological process that can lead to poor patient outcomes. Inflammasome-dependent macrophage pyroptosis contributes to organ damage caused by ischem...

    Authors: Lin Fei, Xiao Jingyuan, Liang Fangte, Dai Huijun, Ye Liu, Jing Ren, Lin Jinyuan and Pan Linghui

    Citation: Journal of Translational Medicine 2020 18:301

    Content type: Research

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  17. Previous research has focused on intensive care unit (ICU)-acquired hypernatremia; however, ICU-acquired hyponatremia has frequently been overlooked and has rarely been studied in surgical or mixed ICUs. The a...

    Authors: Jae Kyeom Sim, Ryoung-Eun Ko, Soo Jin Na, Gee Young Suh and Kyeongman Jeon

    Citation: Journal of Translational Medicine 2020 18:268

    Content type: Research

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  18. Extracorporeal membrane oxygenation (ECMO) is increasingly used in intensive care units and can modify drug pharmacokinetics and lead to under-exposure associated with treatment failure. Ceftolozane/tazobactam...

    Authors: Camille Mané, Clément Delmas, Jean Porterie, Géraldine Jourdan, Patrick Verwaerde, Bertrand Marcheix, Didier Concordet, Bernard Georges, Stéphanie Ruiz and Peggy Gandia

    Citation: Journal of Translational Medicine 2020 18:213

    Content type: Research

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  19. In sepsis, the endothelial barrier becomes incompetent, with the leaking of plasma into interstitial tissues. VE-cadherin, an adherens junction protein, is the gatekeeper of endothelial cohesion. Kinins, relea...

    Authors: Stéphanie Ruiz, Fanny Vardon-Bounes, Marie Buléon, Céline Guilbeau-Frugier, Marie-Hélène Séguelas, Jean-Marie Conil, Jean-Pierre Girolami, Ivan Tack and Vincent Minville

    Citation: Journal of Translational Medicine 2020 18:174

    Content type: Research

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  20. Sphingosine-1-phosphate (S1P) is a signaling phospholipid involved in pathophysiologic progression of acute respiratory distress syndrome (ARDS) through its roles in endothelial barrier function and immune mod...

    Authors: Jiangnan Zhao, Yan Tan, Li Wang, Xin Su and Yi Shi

    Citation: Journal of Translational Medicine 2020 18:156

    Content type: Research

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  21. We have reported that polydatin (PD) alleviates mitochondrial dysfunction in rat models of sepsis-induced acute kidney injury (SI-AKI), but the mechanism is not well understood. Here, we investigated the role ...

    Authors: Youguang Gao, Xingui Dai, Yunfeng Li, Guicheng Li, Xianzhong Lin, Chenmu Ai, Yuanyuan Cao, Tao Li and Bo Lin

    Citation: Journal of Translational Medicine 2020 18:114

    Content type: Research

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  22. An impedance threshold device (ITD) was developed to increase venous return to the heart and therefore increase cardiac output and organ blood flow during cardiopulmonary rescue (CPR). Basic CPR aims to mainta...

    Authors: Benedict Kjaergaard, Hans O. Holdgaard, Sigridur O. Magnusdottir, Søren Lundbye-Christensen and Erika F. Christensen

    Citation: Journal of Translational Medicine 2020 18:83

    Content type: Research

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  23. Despite goal-directed hemodynamic therapy, vascular function may deteriorate during surgery for advanced abdominal tumor masses. Fluid administration has been shown to be associated with distinct changes in se...

    Authors: Jennifer Gehlen, Sven Klaschik, Claudia Neumann, Mignon-Denise Keyver-Paik, Alexander Mustea, Martin Soehle, Stilla Frede, Markus Velten, Andreas Hoeft and Tobias Hilbert

    Citation: Journal of Translational Medicine 2020 18:48

    Content type: Research

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  24. Pain is the vital sense preventing tissue damage by harmful noxious stimuli. The capsaicin receptor TRPV1 is activated by noxious temperatures, however, acute heat pain is only marginally affected in mice afte...

    Authors: Daniela C. Rosenberger, Uta Binzen, Rolf-Detlef Treede and Wolfgang Greffrath

    Citation: Journal of Translational Medicine 2020 18:28

    Content type: Research

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  25. Tibial fracture is associated with inflammatory reaction leading to severe pain syndrome. Bradykinin receptor activation is involved in inflammatory reactions, but has never been investigated in fracture pain.

    Authors: Vincent Minville, Lionel Mouledous, Acil Jaafar, Réjean Couture, Anne Brouchet, Bernard Frances, Ivan Tack and Jean-Pierre Girolami

    Citation: Journal of Translational Medicine 2019 17:346

    Content type: Research

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  26. Despite advances in clinical management, there are currently no novel therapeutic targets for acute respiratory distress syndrome (ARDS). DNA methylation, as a reversible process involved in the development an...

    Authors: Shi Zhang, Zongsheng Wu, Jianfeng Xie, Yi Yang, Lei Wang and Haibo Qiu

    Citation: Journal of Translational Medicine 2019 17:345

    Content type: Research

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  27. To develop a machine learning model for predicting acute respiratory distress syndrome (ARDS) events through commonly available parameters, including baseline characteristics and clinical and laboratory parame...

    Authors: Xian-Fei Ding, Jin-Bo Li, Huo-Yan Liang, Zong-Yu Wang, Ting-Ting Jiao, Zhuang Liu, Liang Yi, Wei-Shuai Bian, Shu-Peng Wang, Xi Zhu and Tong-Wen Sun

    Citation: Journal of Translational Medicine 2019 17:326

    Content type: Research

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  28. Experimental studies suggest that testosterone reduces the nociceptive response after inflammatory and neuropathic stimuli, however the underlying mechanisms have not been fully elucidated. The aims of this st...

    Authors: José Osvaldo Barbosa Neto, João Batista Santos Garcia, Maria do Socorro de Souza Cartágenes, Andressa Godoy Amaral, Luiz Fernando Onuchic and Hazem Adel Ashmawi

    Citation: Journal of Translational Medicine 2019 17:287

    Content type: Research

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  29. In our recent clinical trial, increased peripheral concentrations of pro-inflammatory molecular mediators were determined in complex regional pain syndrome (CRPS) patients. After 3 months adjunctive unilateral...

    Authors: Thomas M. Kinfe, Maria Asif, Krishnan V. Chakravarthy, Timothy R. Deer, Jeffery M. Kramer, Thomas L. Yearwood, Rene Hurlemann, Muhammad Sajid Hussain, Susanne Motameny, Prerana Wagle, Peter Nürnberg, Sascha Gravius, Thomas Randau, Nadine Gravius, Shafqat R. Chaudhry and Sajjad Muhammad

    Citation: Journal of Translational Medicine 2019 17:205

    Content type: Research

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  30. Fibroblast growth factor 23 (FGF23) and endothelium-related biomarkers have been related to AKI in critically-ill patients. Also, FGF23 is associated with endothelial dysfunction. In this study, we investigate...

    Authors: Fernanda Macedo de Oliveira Neves, Camila Barbosa Araújo, Daniele Ferreira de Freitas, Bianca Fernandes Távora Arruda, Leonardo José Monteiro de Macêdo Filho, Vivian Brito Salles, Gdayllon Cavalcante Meneses, Alice Maria Costa Martins and Alexandre Braga Libório

    Citation: Journal of Translational Medicine 2019 17:121

    Content type: Research

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  31. Therapeutic plasma exchange (PE) or plasmapheresis is an extracorporeal procedure employed to treat immunological disorders. Exosomes, nanosized vesicles of endosomal origin, mediate intercellular communicatio...

    Authors: Sujay Ramanathan, Sabrina R. Douglas, Guillermo M. Alexander, Botros B. Shenoda, James E. Barrett, Enrique Aradillas, Ahmet Sacan and Seena K. Ajit

    Citation: Journal of Translational Medicine 2019 17:81

    Content type: Research

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  32. T helper (Th) cells regulate sepsis processes, including primary pathogen clear and secondary pathogen defence. The objectives of this study were to determine the early and dynamic alterations of Th1 and Th2 p...

    Authors: Ming Xue, Jianfeng Xie, Ling Liu, Yingzi Huang, Fengmei Guo, Jingyuan Xu, Yi Yang and Haibo Qiu

    Citation: Journal of Translational Medicine 2019 17:57

    Content type: Research

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  33. Rising evidence indicate that oxytocin and IL-1β impact trigemino-nociceptive signaling. Current perspectives on migraine physiopathology emphasize a cytokine bias towards a pro-inflammatory status. The anti-n...

    Authors: Azize Boström, Dirk Scheele, Birgit Stoffel-Wagner, Frigga Hönig, Shafqat R. Chaudhry, Sajjad Muhammad, Rene Hurlemann, Joachim K. Krauss, Ilana S. Lendvai, Krishnan V. Chakravarthy and Thomas M. Kinfe

    Citation: Journal of Translational Medicine 2019 17:53

    Content type: Research

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  34. Dexmedetomidine (DEX) has been reported to promote tumour metastases. However the underlying mechanisms remain unclear. The purpose of this study was to investigate whether DEX promotes tumour metastasis by in...

    Authors: Xiaosan Su, Yaodong Fan, Liu Yang, Jie Huang, Fei Qiao, Yu Fang and Jun Wang

    Citation: Journal of Translational Medicine 2018 16:347

    Content type: Research

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  35. The ProCESS, ARISE, and ProMISe trials have failed to show that early goal-directed therapy (EGDT) reduces mortality in patients with severe sepsis and septic shock. Although lactate-guided therapy (LGT) has b...

    Authors: Xian-Fei Ding, Zi-Yue Yang, Zhen-Tao Xu, Li-Feng Li, Bo Yuan, Li-Na Guo, Le-Xin Wang, Xi Zhu and Tong-Wen Sun

    Citation: Journal of Translational Medicine 2018 16:331

    Content type: Research

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  36. Widespread use of antibiotics in the intensive care unit is a potential cause of the emergence of hospital-acquired pneumonia. This study determined whether Lactobacillus salivarius feeding could reverse antibiot...

    Authors: Tzyy-Bin Tsay, Ming-Chieh Yang, Wan-Hsuan Chang, Pei-Hsuan Chen and Lee-Wei Chen

    Citation: Journal of Translational Medicine 2018 16:225

    Content type: Research

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  37. Dexmedetomidine (Dex) can improve neuronal viability and protect the spinal cord from ischemia–reperfusion (I/R) injury, but the underlying mechanisms are not fully understood. This study investigated the effe...

    Authors: Zhixiang Sun, Tianyun Zhao, Shaojun Lv, Ying Gao, Joe Masters and Hao Weng

    Citation: Journal of Translational Medicine 2018 16:209

    Content type: Research

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  38. It has been shown that severe insult to the immune system may trigger prolonged macrophage characteristics associated with excessive release of monocyte colony stimulating factor (M-CSF). However, it is unclea...

    Authors: Krzysztof Laudanski, Mateusz Zawadka, Jacek Polosak, Jaymin Modi, Matthew DiMeglio, Jacob Gutsche, Wilson Y. Szeto and Monika Puzianowska-Kuznicka

    Citation: Journal of Translational Medicine 2018 16:143

    Content type: Research

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  39. Acute lung injury caused by renal ischemia–reperfusion is one of the leading causes of acute kidney injury-related death. Dexmedetomidine, an α2-adrenergic agonist sedative, has been found to have protective effe...

    Authors: Juanjuan Li, Qian Chen, Xinhai He, Azeem Alam, Jiaolin Ning, Bin Yi, Kaizhi Lu and Jianteng Gu

    Citation: Journal of Translational Medicine 2018 16:78

    Content type: Research

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  40. Septic shock is a major cause of death in intensive care units around the world . The aim of the study was to investigate whether the novel drug R-100 (a superoxide degradation catalyst and nitric oxide donor)...

    Authors: Hiroshi Ito, Erik Malgerud, Sven Asmussen, Ernesto Lopez, Andrew L. Salzman and Perenlei Enkhbaatar

    Citation: Journal of Translational Medicine 2017 15:266

    Content type: Research

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  41. Acute heart failure (AHF) is a frequent reason for hospitalization worldwide and effective treatment options are limited. It is known that AHF is a condition characterized by impaired vasorelaxation, together ...

    Authors: Roman Falls, Michael Seman, Sabine Braat, Joshua Sortino, Jason D. Allen and Christopher J. Neil

    Citation: Journal of Translational Medicine 2017 15:172

    Content type: Protocol

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  42. To assess whether circadian patterns of temperature correlate with further values of intracranial pressure (ICP) in severe brain injury treated with hypothermia.

    Authors: Adriano Barreto Nogueira, Eva Annen, Oliver Boss, Faraneh Farokhzad, Christopher Sikorski and Emanuela Keller

    Citation: Journal of Translational Medicine 2017 15:170

    Content type: Research

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  43. Previous findings have demonstrated that lumbar radicular pain after disc herniation may be associated with up-regulation of inflammatory mediators. In the present study we examined the possible role of extrac...

    Authors: Aurora Moen, Daniel Jacobsen, Santosh Phuyal, Anna Legfeldt, Fred Haugen, Cecilie Røe and Johannes Gjerstad

    Citation: Journal of Translational Medicine 2017 15:89

    Content type: Research

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  44. The vitamin C deficiency disease scurvy is characterised by musculoskeletal pain and recent epidemiological evidence has indicated an association between suboptimal vitamin C status and spinal pain. Furthermor...

    Authors: Anitra C. Carr and Cate McCall

    Citation: Journal of Translational Medicine 2017 15:77

    Content type: Review

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  45. Sepsis delays wound re-epithelialization. In this study we explored the effect of human sepsis sera as well as the effects of cytokines, growth factors and exosomes of sepsis sera treated normal fibroblasts (N...

    Authors: Henna Jaurila, Vesa Koivukangas, Marjo Koskela, Fiia Gäddnäs, Sirpa Salo, Johanna Korvala, Maija Risteli, Toni Karhu, Karl-Heinz Herzig, Tuula Salo and Tero I. Ala-Kokko

    Citation: Journal of Translational Medicine 2017 15:11

    Content type: Research

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  46. Extracorporeal cardiopulmonary resuscitation (E-CPR) is increasingly used as a rescue method in the management of cardiac arrest and provides the opportunity to rapidly induce therapeutic hypothermia. The surv...

    Authors: Harald A. Bergan, Per S. Halvorsen, Helge Skulstad, Erik Fosse and Jan F. Bugge

    Citation: Journal of Translational Medicine 2016 14:345

    Content type: Research

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  47. The C-allele of the aquaporin (AQP5) -1364A/C polymorphism is associated with decreased AQP5 expression but increased 30-day survival in patients with severe sepsis. AQP5 expression might affect survival via a...

    Authors: Katharina Rump, Matthias Unterberg, Lars Bergmann, Agnes Bankfalvi, Anil Menon, Simon Schäfer, André Scherag, Zainab Bazzi, Winfried Siffert, Jürgen Peters and Michael Adamzik

    Citation: Journal of Translational Medicine 2016 14:321

    Content type: Research

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  48. Sepsis is characterized by the loss of the perm-selectivity properties of the glomerular filtration barrier (GFB) with consequent albuminuria. We examined whether the pharmacokinetics–pharmacodynamics (PK/PD) ...

    Authors: Valentina Selmi, Beatrice Loriga, Luca Vitali, Martina Carlucci, Alessandro Di Filippo, Giulio Carta, Eleonora Sgambati, Lorenzo Tofani, Angelo Raffaele De Gaudio, Andrea Novelli and Chiara Adembri

    Citation: Journal of Translational Medicine 2016 14:316

    Content type: Research

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  49. Acute respiratory distress syndrome (ARDS) remains a common organ dysfunction in the critically ill patient. Mechanisms for its development have focused on immune mediated causes, aspects of our understanding ...

    Authors: Sean F. Monaghan, Chun-Shiang Chung, Yaping Chen, Joanne Lomas-Neira, William G. Fairbrother, Daithi S. Heffernan, William G. Cioffi and Alfred Ayala

    Citation: Journal of Translational Medicine 2016 14:312

    Content type: Research

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