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Pain, Critical Care and Anesthesia

Section edited by Yasin S. Al Makadma

Pain, Critical Care and Anesthesia section encompasses three major fields that are often tightly inter-related both historically and in everyday practice. A systematic Translational Medical approach may be our best route towards analysing common links and complete some of our limited understanding of common clinical pictures. Our section will also contribute in the understanding of mechanistic aspect of different anaesthetic agents and molecules and attempt to deepen the insight in the role of pharmacogenetics.

For that to happen, this section welcomes a very wide range of original research and review articles in related areas.

  1. Content type: Research

    Despite advances in clinical management, there are currently no novel therapeutic targets for acute respiratory distress syndrome (ARDS). DNA methylation, as a reversible process involved in the development an...

    Authors: Shi Zhang, Zongsheng Wu, Jianfeng Xie, Yi Yang, Lei Wang and Haibo Qiu

    Citation: Journal of Translational Medicine 2019 17:345

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  2. Content type: Research

    To develop a machine learning model for predicting acute respiratory distress syndrome (ARDS) events through commonly available parameters, including baseline characteristics and clinical and laboratory parame...

    Authors: Xian-Fei Ding, Jin-Bo Li, Huo-Yan Liang, Zong-Yu Wang, Ting-Ting Jiao, Zhuang Liu, Liang Yi, Wei-Shuai Bian, Shu-Peng Wang, Xi Zhu and Tong-Wen Sun

    Citation: Journal of Translational Medicine 2019 17:326

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  3. Content type: Research

    Experimental studies suggest that testosterone reduces the nociceptive response after inflammatory and neuropathic stimuli, however the underlying mechanisms have not been fully elucidated. The aims of this st...

    Authors: José Osvaldo Barbosa Neto, João Batista Santos Garcia, Maria do Socorro de Souza Cartágenes, Andressa Godoy Amaral, Luiz Fernando Onuchic and Hazem Adel Ashmawi

    Citation: Journal of Translational Medicine 2019 17:287

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  4. Content type: Research

    In our recent clinical trial, increased peripheral concentrations of pro-inflammatory molecular mediators were determined in complex regional pain syndrome (CRPS) patients. After 3 months adjunctive unilateral...

    Authors: Thomas M. Kinfe, Maria Asif, Krishnan V. Chakravarthy, Timothy R. Deer, Jeffery M. Kramer, Thomas L. Yearwood, Rene Hurlemann, Muhammad Sajid Hussain, Susanne Motameny, Prerana Wagle, Peter Nürnberg, Sascha Gravius, Thomas Randau, Nadine Gravius, Shafqat R. Chaudhry and Sajjad Muhammad

    Citation: Journal of Translational Medicine 2019 17:205

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  5. Content type: Research

    Fibroblast growth factor 23 (FGF23) and endothelium-related biomarkers have been related to AKI in critically-ill patients. Also, FGF23 is associated with endothelial dysfunction. In this study, we investigate...

    Authors: Fernanda Macedo de Oliveira Neves, Camila Barbosa Araújo, Daniele Ferreira de Freitas, Bianca Fernandes Távora Arruda, Leonardo José Monteiro de Macêdo Filho, Vivian Brito Salles, Gdayllon Cavalcante Meneses, Alice Maria Costa Martins and Alexandre Braga Libório

    Citation: Journal of Translational Medicine 2019 17:121

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  6. Content type: Research

    Therapeutic plasma exchange (PE) or plasmapheresis is an extracorporeal procedure employed to treat immunological disorders. Exosomes, nanosized vesicles of endosomal origin, mediate intercellular communicatio...

    Authors: Sujay Ramanathan, Sabrina R. Douglas, Guillermo M. Alexander, Botros B. Shenoda, James E. Barrett, Enrique Aradillas, Ahmet Sacan and Seena K. Ajit

    Citation: Journal of Translational Medicine 2019 17:81

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  7. Content type: Research

    T helper (Th) cells regulate sepsis processes, including primary pathogen clear and secondary pathogen defence. The objectives of this study were to determine the early and dynamic alterations of Th1 and Th2 p...

    Authors: Ming Xue, Jianfeng Xie, Ling Liu, Yingzi Huang, Fengmei Guo, Jingyuan Xu, Yi Yang and Haibo Qiu

    Citation: Journal of Translational Medicine 2019 17:57

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  8. Content type: Research

    Rising evidence indicate that oxytocin and IL-1β impact trigemino-nociceptive signaling. Current perspectives on migraine physiopathology emphasize a cytokine bias towards a pro-inflammatory status. The anti-n...

    Authors: Azize Boström, Dirk Scheele, Birgit Stoffel-Wagner, Frigga Hönig, Shafqat R. Chaudhry, Sajjad Muhammad, Rene Hurlemann, Joachim K. Krauss, Ilana S. Lendvai, Krishnan V. Chakravarthy and Thomas M. Kinfe

    Citation: Journal of Translational Medicine 2019 17:53

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  9. Content type: Research

    Dexmedetomidine (DEX) has been reported to promote tumour metastases. However the underlying mechanisms remain unclear. The purpose of this study was to investigate whether DEX promotes tumour metastasis by in...

    Authors: Xiaosan Su, Yaodong Fan, Liu Yang, Jie Huang, Fei Qiao, Yu Fang and Jun Wang

    Citation: Journal of Translational Medicine 2018 16:347

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  10. Content type: Research

    The ProCESS, ARISE, and ProMISe trials have failed to show that early goal-directed therapy (EGDT) reduces mortality in patients with severe sepsis and septic shock. Although lactate-guided therapy (LGT) has b...

    Authors: Xian-Fei Ding, Zi-Yue Yang, Zhen-Tao Xu, Li-Feng Li, Bo Yuan, Li-Na Guo, Le-Xin Wang, Xi Zhu and Tong-Wen Sun

    Citation: Journal of Translational Medicine 2018 16:331

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  11. Content type: Research

    Widespread use of antibiotics in the intensive care unit is a potential cause of the emergence of hospital-acquired pneumonia. This study determined whether Lactobacillus salivarius feeding could reverse antibiot...

    Authors: Tzyy-Bin Tsay, Ming-Chieh Yang, Wan-Hsuan Chang, Pei-Hsuan Chen and Lee-Wei Chen

    Citation: Journal of Translational Medicine 2018 16:225

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  12. Content type: Research

    Dexmedetomidine (Dex) can improve neuronal viability and protect the spinal cord from ischemia–reperfusion (I/R) injury, but the underlying mechanisms are not fully understood. This study investigated the effe...

    Authors: Zhixiang Sun, Tianyun Zhao, Shaojun Lv, Ying Gao, Joe Masters and Hao Weng

    Citation: Journal of Translational Medicine 2018 16:209

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  13. Content type: Research

    It has been shown that severe insult to the immune system may trigger prolonged macrophage characteristics associated with excessive release of monocyte colony stimulating factor (M-CSF). However, it is unclea...

    Authors: Krzysztof Laudanski, Mateusz Zawadka, Jacek Polosak, Jaymin Modi, Matthew DiMeglio, Jacob Gutsche, Wilson Y. Szeto and Monika Puzianowska-Kuznicka

    Citation: Journal of Translational Medicine 2018 16:143

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  14. Content type: Research

    Acute lung injury caused by renal ischemia–reperfusion is one of the leading causes of acute kidney injury-related death. Dexmedetomidine, an α2-adrenergic agonist sedative, has been found to have protective effe...

    Authors: Juanjuan Li, Qian Chen, Xinhai He, Azeem Alam, Jiaolin Ning, Bin Yi, Kaizhi Lu and Jianteng Gu

    Citation: Journal of Translational Medicine 2018 16:78

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  15. Content type: Research

    Septic shock is a major cause of death in intensive care units around the world . The aim of the study was to investigate whether the novel drug R-100 (a superoxide degradation catalyst and nitric oxide donor)...

    Authors: Hiroshi Ito, Erik Malgerud, Sven Asmussen, Ernesto Lopez, Andrew L. Salzman and Perenlei Enkhbaatar

    Citation: Journal of Translational Medicine 2017 15:266

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  16. Content type: Protocol

    Acute heart failure (AHF) is a frequent reason for hospitalization worldwide and effective treatment options are limited. It is known that AHF is a condition characterized by impaired vasorelaxation, together ...

    Authors: Roman Falls, Michael Seman, Sabine Braat, Joshua Sortino, Jason D. Allen and Christopher J. Neil

    Citation: Journal of Translational Medicine 2017 15:172

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  17. Content type: Research

    To assess whether circadian patterns of temperature correlate with further values of intracranial pressure (ICP) in severe brain injury treated with hypothermia.

    Authors: Adriano Barreto Nogueira, Eva Annen, Oliver Boss, Faraneh Farokhzad, Christopher Sikorski and Emanuela Keller

    Citation: Journal of Translational Medicine 2017 15:170

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  18. Content type: Research

    Previous findings have demonstrated that lumbar radicular pain after disc herniation may be associated with up-regulation of inflammatory mediators. In the present study we examined the possible role of extrac...

    Authors: Aurora Moen, Daniel Jacobsen, Santosh Phuyal, Anna Legfeldt, Fred Haugen, Cecilie Røe and Johannes Gjerstad

    Citation: Journal of Translational Medicine 2017 15:89

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  19. Content type: Review

    The vitamin C deficiency disease scurvy is characterised by musculoskeletal pain and recent epidemiological evidence has indicated an association between suboptimal vitamin C status and spinal pain. Furthermor...

    Authors: Anitra C. Carr and Cate McCall

    Citation: Journal of Translational Medicine 2017 15:77

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  20. Content type: Research

    Sepsis delays wound re-epithelialization. In this study we explored the effect of human sepsis sera as well as the effects of cytokines, growth factors and exosomes of sepsis sera treated normal fibroblasts (N...

    Authors: Henna Jaurila, Vesa Koivukangas, Marjo Koskela, Fiia Gäddnäs, Sirpa Salo, Johanna Korvala, Maija Risteli, Toni Karhu, Karl-Heinz Herzig, Tuula Salo and Tero I. Ala-Kokko

    Citation: Journal of Translational Medicine 2017 15:11

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  21. Content type: Research

    Extracorporeal cardiopulmonary resuscitation (E-CPR) is increasingly used as a rescue method in the management of cardiac arrest and provides the opportunity to rapidly induce therapeutic hypothermia. The surv...

    Authors: Harald A. Bergan, Per S. Halvorsen, Helge Skulstad, Erik Fosse and Jan F. Bugge

    Citation: Journal of Translational Medicine 2016 14:345

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  22. Content type: Research

    The C-allele of the aquaporin (AQP5) -1364A/C polymorphism is associated with decreased AQP5 expression but increased 30-day survival in patients with severe sepsis. AQP5 expression might affect survival via a...

    Authors: Katharina Rump, Matthias Unterberg, Lars Bergmann, Agnes Bankfalvi, Anil Menon, Simon Schäfer, André Scherag, Zainab Bazzi, Winfried Siffert, Jürgen Peters and Michael Adamzik

    Citation: Journal of Translational Medicine 2016 14:321

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  23. Content type: Research

    Sepsis is characterized by the loss of the perm-selectivity properties of the glomerular filtration barrier (GFB) with consequent albuminuria. We examined whether the pharmacokinetics–pharmacodynamics (PK/PD) ...

    Authors: Valentina Selmi, Beatrice Loriga, Luca Vitali, Martina Carlucci, Alessandro Di Filippo, Giulio Carta, Eleonora Sgambati, Lorenzo Tofani, Angelo Raffaele De Gaudio, Andrea Novelli and Chiara Adembri

    Citation: Journal of Translational Medicine 2016 14:316

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  24. Content type: Research

    Acute respiratory distress syndrome (ARDS) remains a common organ dysfunction in the critically ill patient. Mechanisms for its development have focused on immune mediated causes, aspects of our understanding ...

    Authors: Sean F. Monaghan, Chun-Shiang Chung, Yaping Chen, Joanne Lomas-Neira, William G. Fairbrother, Daithi S. Heffernan, William G. Cioffi and Alfred Ayala

    Citation: Journal of Translational Medicine 2016 14:312

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  25. Content type: Research

    The noble gas helium induces pre- and postconditioning in animals and humans. Volatile anesthetics induce cardioprotection in humans undergoing coronary artery bypass graft (CABG) surgery. We hypothesized that...

    Authors: Kirsten F. Smit, Daniel Brevoord, Stefan De Hert, Bas A. de Mol, Raphaela P. Kerindongo, Susan van Dieren, Wolfgang S. Schlack, Markus W. Hollmann, Nina C. Weber and Benedikt Preckel

    Citation: Journal of Translational Medicine 2016 14:294

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  26. Content type: Research

    Current research highlights the role of microcirculatory disorders in post-cardiac arrest patients. Affected microcirculation shows not only dissociation from systemic hemodynamics but also strong connection t...

    Authors: Petra Krupičková, Mikuláš Mlček, Michal Huptych, Zuzana Mormanová, Tomáš Bouček, Tomáš Belza, Stanislav Lacko, Miloš Černý, Petr Neužil, Otomar Kittnar, Aleš Linhart and Jan Bělohlávek

    Citation: Journal of Translational Medicine 2016 14:163

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  27. Content type: Research

    Ketamine provides relief for a subset of patients with complex regional pain syndrome (CRPS). The poor responders had a lower body mass index (BMI) relative to responders. Regulation of proopiomelanocortin (PO...

    Authors: Botros B. Shenoda, Guillermo M. Alexander and Seena K. Ajit

    Citation: Journal of Translational Medicine 2016 14:64

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  28. Content type: Research

    Volume resuscitation with hydroxyethyl starch (HES) is controversially discussed and we recently showed that HES perfusion impairs endothelial and epithelial intestinal barrier integrity. Here we investigated ...

    Authors: Yuk Lung Wong, Ingmar Lautenschläger, Karina Zitta, Christin Schildhauer, Kerstin Parczany, Christoph Röcken, Markus Steinfath, Norbert Weiler and Martin Albrecht

    Citation: Journal of Translational Medicine 2016 14:60

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  29. Content type: Review

    The repair of organs and tissues has stepped into a prospective era of regenerative medicine. However, basic research and clinical practice in the lung regeneration remains crawling. Owing to the complicated t...

    Authors: Ce Yang, Jianxin Jiang, Xuetao Yang, Haiyan Wang and Juan Du

    Citation: Journal of Translational Medicine 2016 14:47

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  30. Content type: Research

    In kidney transplantation, the conditions of organ preservation following removal influence function recovery. Current static preservation procedures are generally based on immersion in a cold-storage solution...

    Authors: Alice Faure, Laurie Bruzzese, Jean-Guillaume Steinberg, Yves Jammes, Julia Torrents, Stephane V. Berdah, Emmanuelle Garnier, Tristan Legris, Anderson Loundou, Matthieu Chalopin, Guy Magalon, Regis Guieu, Emmanuel Fenouillet and Eric Lechevallier

    Citation: Journal of Translational Medicine 2016 14:40

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  31. Content type: Research

    Post-liver transplantation acute lung injury (ALI) severely affects patients’ survival, whereas the mechanism is unclear and effective therapy is lacking. The authors postulated that reperfusion-induced increa...

    Authors: Xinjin Chi, Na Guo, Weifeng Yao, Yi Jin, Wanling Gao, Jun Cai and Ziqing Hei

    Citation: Journal of Translational Medicine 2016 14:35

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  32. Content type: Research

    Regional anesthesia has several advantages over general anesthesia but requires accurate needle placement to be effective. To achieve accurate placement, a needle equipped with optical fibers that allows tiss...

    Authors: Benno H. W. Hendriks, Andrea J. R. Balthasar, Gerald W. Lucassen, Marjolein van der Voort, Manfred Mueller, Vishnu V. Pully, Torre M. Bydlon, Christian Reich, Arnold T. M. H. van Keersop, Jeroen Kortsmit, Gerrit C. Langhout and Geert-Jan van Geffen

    Citation: Journal of Translational Medicine 2015 13:380

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  33. Content type: Research

    Processed Chuanwu (PCW), the mother root of Aconitum carmichaelii Debeaux, has been widely used as a classic Traditional Chinese Medicine for pain relieve for over two millennia clinic...

    Authors: Chao Wang, Danni Sun, Chunfang Liu, Chunyan Zhu, Xianghong Jing, Shuping Chen, Cuiling Liu, Kai Zhi, Tengfei Xu, Hui Wang, Junling Liu, Ying Xu, Zhiqiang Liu and Na Lin

    Citation: Journal of Translational Medicine 2015 13:284

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  34. Content type: Research

    Diabetic neuropathy is one of the most common complications of diabetes and causes various problems in daily life. The aim of this study was to assess the effect of regional anaesthesia on post surgery opioid ...

    Authors: Anne Gomez-Brouchet, Nelly Blaes, Lionel Mouledous, Olivier Fourcade, Ivan Tack, Bernard Francès, Jean-Pierre Girolami and Vincent Minville

    Citation: Journal of Translational Medicine 2015 13:208

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  35. Content type: Research

    To investigate whether pretreatment with dexmedetomidine (Dex) has a protective effect against acute lung injury (ALI) in an orthotopic autologous liver transplantation (OALT) rat model and to explore the mech...

    Authors: Xinjin Chi, Xiaoxia Wei, Wanling Gao, Jianqiang Guan, Xiaofan Yu, Yiheng Wang, Xi Li and Jun Cai

    Citation: Journal of Translational Medicine 2015 13:190

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  36. Content type: Research

    Early acute kidney injury (AKI) in severely burned patients predicts a high mortality that is multi-factorial. Hydrogen has been reported to alleviate organ injury via selective quenching of reactive oxygen sp...

    Authors: Song-Xue Guo, Quan Fang, Chuan-Gang You, Yun-Yun Jin, Xin-Gang Wang, Xin-Lei Hu and Chun-Mao Han

    Citation: Journal of Translational Medicine 2015 13:183

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  37. Content type: Research

    Acupuncture has analgesic effect to most pain conditions. Many neuroimaging studies were conducted to explore acupoint specificity in pain and other condition, but till now there is still discrepancy. Based on...

    Authors: Mingxiao Yang, Jie Yang, Fang Zeng, Peng Liu, Zhenhong Lai, Shufang Deng, Li Fang, Wenzhong Song, Hongjun Xie and Fanrong Liang

    Citation: Journal of Translational Medicine 2014 12:351

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