Pain, Critical Care and Anesthesia

Section edited by Yasin S. Al Makadma

Pain, Critical Care and Anesthesia section encompasses three major fields that are often tightly inter-related both historically and in everyday practice. A systematic Translational Medical approach may be our best route towards analysing common links and complete some of our limited understanding of common clinical pictures. Our section will also contribute in the understanding of mechanistic aspect of different anaesthetic agents and molecules and attempt to deepen the insight in the role of pharmacogenetics.

For that to happen, this section welcomes a very wide range of original research and review articles in related areas.

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  1. Research

    MicroRNA-223 demonstrated experimentally in exosome-like vesicles is associated with decreased risk of persistent pain after lumbar disc herniation

    Previous findings have demonstrated that lumbar radicular pain after disc herniation may be associated with up-regulation of inflammatory mediators. In the present study we examined the possible role of extrac...

    Aurora Moen, Daniel Jacobsen, Santosh Phuyal, Anna Legfeldt, Fred Haugen, Cecilie Røe and Johannes Gjerstad

    Journal of Translational Medicine 2017 15:89

    Published on: 1 May 2017

  2. Review

    The role of vitamin C in the treatment of pain: new insights

    The vitamin C deficiency disease scurvy is characterised by musculoskeletal pain and recent epidemiological evidence has indicated an association between suboptimal vitamin C status and spinal pain. Furthermor...

    Anitra C. Carr and Cate McCall

    Journal of Translational Medicine 2017 15:77

    Published on: 14 April 2017

  3. Research

    Inhibitory effects of serum from sepsis patients on epithelial cell migration in vitro: a case control study

    Sepsis delays wound re-epithelialization. In this study we explored the effect of human sepsis sera as well as the effects of cytokines, growth factors and exosomes of sepsis sera treated normal fibroblasts (N...

    Henna Jaurila, Vesa Koivukangas, Marjo Koskela, Fiia Gäddnäs, Sirpa Salo, Johanna Korvala, Maija Risteli, Toni Karhu, Karl-Heinz Herzig, Tuula Salo and Tero I. Ala-Kokko

    Journal of Translational Medicine 2017 15:11

    Published on: 13 January 2017

  4. Research

    Does therapeutic hypothermia during extracorporeal cardiopulmonary resuscitation preserve cardiac function?

    Extracorporeal cardiopulmonary resuscitation (E-CPR) is increasingly used as a rescue method in the management of cardiac arrest and provides the opportunity to rapidly induce therapeutic hypothermia. The surv...

    Harald A. Bergan, Per S. Halvorsen, Helge Skulstad, Erik Fosse and Jan F. Bugge

    Journal of Translational Medicine 2016 14:345

    Published on: 20 December 2016

  5. Research

    AQP5-1364A/C polymorphism and the AQP5 expression influence sepsis survival and immune cell migration: a prospective laboratory and patient study

    The C-allele of the aquaporin (AQP5) -1364A/C polymorphism is associated with decreased AQP5 expression but increased 30-day survival in patients with severe sepsis. AQP5 expression might affect survival via a...

    Katharina Rump, Matthias Unterberg, Lars Bergmann, Agnes Bankfalvi, Anil Menon, Simon Schäfer, André Scherag, Zainab Bazzi, Winfried Siffert, Jürgen Peters and Michael Adamzik

    Journal of Translational Medicine 2016 14:321

    Published on: 21 November 2016

  6. Research

    Changes in ceftriaxone pharmacokinetics/pharmacodynamics during the early phase of sepsis: a prospective, experimental study in the rat

    Sepsis is characterized by the loss of the perm-selectivity properties of the glomerular filtration barrier (GFB) with consequent albuminuria. We examined whether the pharmacokinetics–pharmacodynamics (PK/PD) ...

    Valentina Selmi, Beatrice Loriga, Luca Vitali, Martina Carlucci, Alessandro Di Filippo, Giulio Carta, Eleonora Sgambati, Lorenzo Tofani, Angelo Raffaele De Gaudio, Andrea Novelli and Chiara Adembri

    Journal of Translational Medicine 2016 14:316

    Published on: 15 November 2016

  7. Research

    Soluble programmed cell death receptor-1 (sPD-1): a potential biomarker with anti-inflammatory properties in human and experimental acute respiratory distress syndrome (ARDS)

    Acute respiratory distress syndrome (ARDS) remains a common organ dysfunction in the critically ill patient. Mechanisms for its development have focused on immune mediated causes, aspects of our understanding ...

    Sean F. Monaghan, Chun-Shiang Chung, Yaping Chen, Joanne Lomas-Neira, William G. Fairbrother, Daithi S. Heffernan, William G. Cioffi and Alfred Ayala

    Journal of Translational Medicine 2016 14:312

    Published on: 11 November 2016

  8. Research

    Effect of helium pre- or postconditioning on signal transduction kinases in patients undergoing coronary artery bypass graft surgery

    The noble gas helium induces pre- and postconditioning in animals and humans. Volatile anesthetics induce cardioprotection in humans undergoing coronary artery bypass graft (CABG) surgery. We hypothesized that...

    Kirsten F. Smit, Daniel Brevoord, Stefan De Hert, Bas A. de Mol, Raphaela P. Kerindongo, Susan van Dieren, Wolfgang S. Schlack, Markus W. Hollmann, Nina C. Weber and Benedikt Preckel

    Journal of Translational Medicine 2016 14:294

    Published on: 14 October 2016

  9. Research

    Microcirculatory blood flow during cardiac arrest and cardiopulmonary resuscitation does not correlate with global hemodynamics: an experimental study

    Current research highlights the role of microcirculatory disorders in post-cardiac arrest patients. Affected microcirculation shows not only dissociation from systemic hemodynamics but also strong connection t...

    Petra Krupičková, Mikuláš Mlček, Michal Huptych, Zuzana Mormanová, Tomáš Bouček, Tomáš Belza, Stanislav Lacko, Miloš Černý, Petr Neužil, Otomar Kittnar, Aleš Linhart and Jan Bělohlávek

    Journal of Translational Medicine 2016 14:163

    Published on: 8 June 2016

  10. Research

    Hsa-miR-34a mediated repression of corticotrophin releasing hormone receptor 1 regulates pro-opiomelanocortin expression in patients with complex regional pain syndrome

    Ketamine provides relief for a subset of patients with complex regional pain syndrome (CRPS). The poor responders had a lower body mass index (BMI) relative to responders. Regulation of proopiomelanocortin (PO...

    Botros B. Shenoda, Guillermo M. Alexander and Seena K. Ajit

    Journal of Translational Medicine 2016 14:64

    Published on: 3 March 2016

  11. Research

    Adverse effects of hydroxyethyl starch (HES 130/0.4) on intestinal barrier integrity and metabolic function are abrogated by supplementation with Albumin

    Volume resuscitation with hydroxyethyl starch (HES) is controversially discussed and we recently showed that HES perfusion impairs endothelial and epithelial intestinal barrier integrity. Here we investigated ...

    Yuk Lung Wong, Ingmar Lautenschläger, Karina Zitta, Christin Schildhauer, Kerstin Parczany, Christoph Röcken, Markus Steinfath, Norbert Weiler and Martin Albrecht

    Journal of Translational Medicine 2016 14:60

    Published on: 27 February 2016

  12. Research

    Effectiveness of pure argon for renal transplant preservation in a preclinical pig model of heterotopic autotransplantation

    In kidney transplantation, the conditions of organ preservation following removal influence function recovery. Current static preservation procedures are generally based on immersion in a cold-storage solution...

    Alice Faure, Laurie Bruzzese, Jean-Guillaume Steinberg, Yves Jammes, Julia Torrents, Stephane V. Berdah, Emmanuelle Garnier, Tristan Legris, Anderson Loundou, Matthieu Chalopin, Guy Magalon, Regis Guieu, Emmanuel Fenouillet and Eric Lechevallier

    Journal of Translational Medicine 2016 14:40

    Published on: 4 February 2016

  13. Research

    Induction of heme oxygenase-1 by hemin protects lung against orthotopic autologous liver transplantation-induced acute lung injury in rats

    Post-liver transplantation acute lung injury (ALI) severely affects patients’ survival, whereas the mechanism is unclear and effective therapy is lacking. The authors postulated that reperfusion-induced increa...

    Xinjin Chi, Na Guo, Weifeng Yao, Yi Jin, Wanling Gao, Jun Cai and Ziqing Hei

    Journal of Translational Medicine 2016 14:35

    Published on: 2 February 2016

  14. Research

    Nerve detection with optical spectroscopy for regional anesthesia procedures

    Regional anesthesia has several advantages over general anesthesia but requires accurate needle placement to be effective. To achieve accurate placement, a needle equipped with optical fibers that allows tiss...

    Benno H. W. Hendriks, Andrea J. R. Balthasar, Gerald W. Lucassen, Marjolein van der Voort, Manfred Mueller, Vishnu V. Pully, Torre M. Bydlon, Christian Reich, Arnold T. M. H. van Keersop, Jeroen Kortsmit, Gerrit C. Langhout and Geert-Jan van Geffen

    Journal of Translational Medicine 2015 13:380

    Published on: 15 December 2015

  15. Research

    Mother root of Aconitum carmichaelii Debeaux exerts antinociceptive effect in Complete Freund’s Adjuvant-induced mice: roles of dynorphin/kappa-opioid system and transient receptor potential vanilloid type-1 ion channel

    Processed Chuanwu (PCW), the mother root of Aconitum carmichaelii Debeaux, has been widely used as a classic Traditional Chinese Medicine for pain relieve for over two millennia clinic...

    Chao Wang, Danni Sun, Chunfang Liu, Chunyan Zhu, Xianghong Jing, Shuping Chen, Cuiling Liu, Kai Zhi, Tengfei Xu, Hui Wang, Junling Liu, Ying Xu, Zhiqiang Liu and Na Lin

    Journal of Translational Medicine 2015 13:284

    Published on: 30 August 2015

  16. Research

    Beneficial effects of levobupivacaine regional anaesthesia on postoperative opioid induced hyperalgesia in diabetic mice

    Diabetic neuropathy is one of the most common complications of diabetes and causes various problems in daily life. The aim of this study was to assess the effect of regional anaesthesia on post surgery opioid ...

    Anne Gomez-Brouchet, Nelly Blaes, Lionel Mouledous, Olivier Fourcade, Ivan Tack, Bernard Francès, Jean-Pierre Girolami and Vincent Minville

    Journal of Translational Medicine 2015 13:208

    Published on: 2 July 2015

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