Journal of Translational Medicine

Featured Section: ImmunoVirology and ImmunoOncology

The ImmunoVirology and ImmunoOncology section focuses on translational research related to immunity to viral-related or cancer-related diseases.

Edited by Luigi Buonaguro, the section welcomes submissions of studies focusing on the role of innate, as well as adaptive, immunity in the establishment, containment and/or progression of viral infections as well as of cancers, including preventive or therapeutic vaccines, adjuvanting strategies and adoptive cell therapies.

Read the latest articles in the ImmunoVirology and ImmunoOncology section

Featured research: Spatial transcriptomics atlas reveals the crosstalk between cancer-associated fibroblasts and tumor microenvironment components in colorectal cancer

The tumor-promoting role of tumor microenvironment (TME) in colorectal cancer has been widely investigated in cancer biology. Cancer-associated fibroblasts (CAFs), as the main stromal component in TME, play an important role in promoting tumor progression and metastasis. Some studies have identified different types of CAFs at the single-cell level according to unique gene signatures or functions. However, the types and functions of CAFs varies in different studies or tumor types, suggesting that the functional roles of CAFs in TME is complicated and yet has not been clearly explained.

In this article, Peng and colleagues explored the corsstalk between CAFs and microenvironment in the pathogenesis of colorectal cancer in order to provide basis for precision therapy. Two types of CAFs were identified using integrated data and researchers explored the functional significance of TME.

Featured review: Emerging role of human microbiome in cancer development and response to therapy

According to the involvement of microbiota in modulating physiological processes, any alteration in its composition and diversity has been linked to a variety of pathologies, including cancer. In this bidirectional relationship, colonization with various bacterial species is correlated with a reduced or elevated risk of certain cancers. Notably, the gut microflora could potentially play a direct or indirect role in tumor initiation and progression by inducing chronic inflammation and producing toxins and metabolites. Therefore, identifying the bacterial species involved and their mechanism of action could be beneficial in preventing the onset of tumors or controlling their advancement. Likewise, the microbial community affects anti-cancer approaches’ therapeutic potential and adverse effects.

In this review, Sadrekarimi et al summarize the evidence revealing the microbiota's involvement in cancer and its mechanism, and also delineated how microbiota could predict colon carcinoma development or response to current treatments to improve clinical outcomes.

Chagasic cardiomyopathy is marked by a unique signature of activated CD4⁺ T cells

Authors: Gregório Guilherme Almeida, Inga Rimkute, Isabela Natália Pascoal Campos do Vale, Thomas Liechti, Priscilla Miranda Henriques, Ester Roffe, Fernanda Fortes de Araújo, Manoel Otávio da Costa Rocha, Silvana Maria Elói Santos, Olindo Assis Martins-Filho, Dragana Jankovic, Alan Sher, Andrea Teixeira-Carvalho, Mario Roederer and Lis Ribeiro do Valle Antonelli

Content type: Research 30 November 2022
Evaluating the frequency and the impact of pharmacogenetic alleles in an ancestrally diverse Biobank population

Authors: Shefali S. Verma, Karl Keat, Binglan Li, Glenda Hoffecker, Marjorie Risman, Katrin Sangkuhl, Michelle Whirl-Carrillo, Scott Dudek, Anurag Verma, Teri E. Klein, Marylyn D. Ritchie and Sony Tuteja

Content type: Research 28 November 2022
Unilateral acute lung injury in pig: a promising animal model

Authors: Johannes Geilen, Matthias Kainz, Bernhard Zapletal, Silvana Geleff, Wilfried Wisser, Barbara Bohle, Thomas Schweiger, Marcus J. Schultz and Edda Tschernko

Content type: Research 26 November 2022
Effects of hydrogen-rich saline in neuroinflammation and mitochondrial dysfunction in rat model of sepsis-associated encephalopathy

Authors: John Sieh Dumbuya, Siqi Li, Lili Liang, Yanchen Chen, Jiang Du and Qiyi Zeng

Content type: Research 26 November 2022
Comparison of clinical outcomes of frozen-thawed D5 and D6 blastocysts undergoing preimplantation genetic testing

Authors: Guanling Yu, Shuiying Ma, Hui Liu, Yujin Liu, Haozhen Zhang, Wenjia Zhang and Keliang Wu

Content type: Research 26 November 2022

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Eating habits and lifestyle changes during COVID-19 lockdown: an Italian survey

Authors: Laura Di Renzo, Paola Gualtieri, Francesca Pivari, Laura Soldati, Alda Attinà, Giulia Cinelli, Claudia Leggeri, Giovanna Caparello, Luigi Barrea, Francesco Scerbo, Ernesto Esposito and Antonino De Lorenzo

Content type: Research 8 June 2020
Effects of eight weeks of time-restricted feeding (16/8) on basal metabolism, maximal strength, body composition, inflammation, and cardiovascular risk factors in resistance-trained males

Authors: Tatiana Moro, Grant Tinsley, Antonino Bianco, Giuseppe Marcolin, Quirico Francesco Pacelli, Giuseppe Battaglia, Antonio Palma, Paulo Gentil, Marco Neri and Antonio Paoli

Content type: Research 13 October 2016
Why tocilizumab could be an effective treatment for severe COVID-19?

Authors: Binqing Fu, Xiaoling Xu and Haiming Wei

Content type: Commentary 14 April 2020
Influence of diet on the gut microbiome and implications for human health

Authors: Rasnik K. Singh, Hsin-Wen Chang, Di Yan, Kristina M. Lee, Derya Ucmak, Kirsten Wong, Michael Abrouk, Benjamin Farahnik, Mio Nakamura, Tian Hao Zhu, Tina Bhutani and Wilson Liao

Content type: Review 8 April 2017
Neutrophil-to-lymphocyte ratio predicts critical illness patients with 2019 coronavirus disease in the early stage

Authors: Jingyuan Liu, Yao Liu, Pan Xiang, Lin Pu, Haofeng Xiong, Chuansheng Li, Ming Zhang, Jianbo Tan, Yanli Xu, Rui Song, Meihua Song, Lin Wang, Wei Zhang, Bing Han, Li Yang, Xiaojing Wang…

Content type: Research 20 May 2020

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Journal of Translational Medicine has launched In Review, a new option that provides authors with on-demand information on the status of their manuscript, enables them to share their work with funders and their research community, and allows their colleagues to comment and collaborate - all whilst their manuscript is under review.

Meet the Editors

Get to know the Editors behind Journal of Translational Medicine!

Journal News

Please note that Journal of Translational Medicine is no longer considering submissions of study protocols.

Editor Spotlight

^{Section: Combination Strategies}

Dr Alessio Cortellini is a consultant in medical oncology and a clinical scientist with a special interest in immunotherapy of cancer and lung cancer. After leading the immunotherapy program at University of L’Aquila in Italy for more than a year, he moved to London in 2020, where he worked in the early phase clinical trial unit at Imperial College London.

In July 2022, he moved to Rome and he is now working at the Fondazione Policlinico Universitario Campus Bio-Medico in Rome. However, given the fruitful collaboration and the number of high-level research goals achieved during his fellowship at Imperial College, he is keeping his honorary academic post as Honorary Clinical Lecturer with Imperial College London.

View the previous 'Editor Spotlights' here

Our companion journal

Translational Medicine Communications. the companion journal to Journal of Translational Medicine, is an interdisciplinary forum for all scientifically valid research from across translational medicine.

The journal aims to improve transparency and reproducibility within translational medicine and considers research papers regardless of outcome or significance of findings.

Explore Translational Medicine Communications

Introducing new sections to Journal of Translational Medicine!

Cellular Metabolism Therapy

Led by Section Editor Salvatore Nesci, this new section aims to promote the translation of basic research emerging from biochemistry, molecular medicine, physiology and biotechnology into cell metabolism in order to be exploited in clinical applications.

Cellular Metabolism Therapy will consider research that covers any aspect of translational metabolic research, including (but not limited to): genetic disorders and epigenetic diseases; metabolic derangements causing neurodegeneration; immunometabolism; stroke; cardiovascular diseases; tumours; stem cell bioenergetics; ageing; carbohydrate, lipid, and protein metabolism.

Translational Signaling and System Biology

© © selvanegra / Getty Images / iStock Led by Section Editor Marcello Maggiolini, this exciting new section is dedicated to uncovering pivotal transduction signaling involved in pathophysiological processes toward a translational impact on the discovery of novel targets and therapeutics.

Translational Signaling and System Biology section welcomes articles providing new mechanistic insights on a broad range of fields, drug action through new formulations and delivery methods, novel cellular and animal models, computational and systems biology, and innovative laboratory concepts fostering translational research from the bench to the bedside.

Editor-in-Chief: Francesco Marincola, Kite Pharma, USA

Dr. Marincola received his MD, summa cum laude from the University of Milan, Italy and Surgery training at Stanford University, California. His research interest lies in translational medicine and focuses on the development of strategies for the dynamic study of patients’ response to immunotherapy. His approach has brought seminal observations regarding the mechanisms leading to rejection of tumors, allograft rejection, graft-versus-host disease and autoimmunity.

Dr. Marincola is currently Global Head of Research at Kite Pharma, Santa Monica, California. He previously was President and Chief Scientific Officer at Refuge Biotechnologies, Menlo Park, California, Distinguished Research Fellow at AbbVie Corporation in Redwood City, California, Chief Research Officer at Sidra Medical and Research Center in Doha Qatar and Tenured Investigator at the National Institutes of Health, Bethesda Maryland. Dr. Marincola founded in 2003 the Journal of Translational Medicine of which he is currently the Editor-in-Chief. He is also Editor-in-Chief of Translational Medicine Communications. He is past-president of the Society for the Immunotherapy of Cancer (SITC) and of the International Society for Translational Medicine. Dr. Marincola is editor of several biomedical books including the SITC-affiliated Cancer Immunotherapy Principles and Practice Textbook. Dr. Marincola is an award winning fiction writer author of The Wise Men of Pizzo and the Cat Behind the Window.

Aims and scope

Journal of Translational Medicine is an open access journal publishing articles focusing on information derived from human experimentation so as to optimise the communication between basic and clinical science.

The journal covers all areas of translational medicine but also has several special sections:

Cancer Metabolism
Edited by Violena Pietrobon
Cancer Microenvironment
Edited by Davide Bedognetti
Cardiovascular, Metabolic and Lipoprotein Translation
Edited by Nehal N. Mehta and Tommaso Angelone
Cell, Tissue and Gene Therapy
Edited by David Stroncek
Cellular Metabolism Therapy
Edited by Salvatore Nesci
Clinical Translation
Combination Strategies
Edited by Paolo A. Ascierto
Computational Modelling and Epidemiology
Edited by Michael Liebman and Sabrina Molinaro
Data-driven Clinical Decision Processes
Edited by Enrico Capobianco
Disease Biomarkers
Edited by Xiangdong Wang and Dr Hao Fang
Emerging Therapeutics
Edited by Gennaro Ciliberto

Fibrosis
Edited by Mary Salvatore
Hot Topics
Edited by Richard Ablin and Marcello Maggiolini
Human Reproductive Biology and Reproductive Medicine
Edited by Matteo Alessandro Avella
Illnesses of Unknown Etiology
Edited by Monica Panelli
Immune RadioBiology
Edited by Claire Vanpouille-Box
Immunobiology and Immunotherapy
Edited by Alessandra Cesano
ImmunoVirology and ImmunoOncology
Edited by Luigi Buonaguro
Medical Bioinformatics
Edited by Michele Ceccarelli
Neuroscience
Edited by Maria Jose Polanco Mora
Nutrition & Metabolism
Edited by Laura Soldati
Pain, Critical Care and Anesthesia
Edited by Yasin S. Al Makadma and Ahmed Labib

Patient-targeted Molecular Therapies
Personalized Medicine
Edited by Jingxuan Shan
Translational Cancer Biology
Edited by Cristina Maccalli
Translational Craniofacial and Dental Medicine
Edited by Giuseppe Intini
Translational Genomics and Genetics
Edited by Wei Liu
Translational Hematology
Edited by Seah H. Lim
Translational Imaging
Edited by Ravinder Reddy and Mohammed Haris
Translational Medicines 'Ecosystem'
Edited by Vijay Mahant
Translational Metagenomics
Edited by Souhaila Al Khodor
Translational Signaling and System Biology
Edited by Marcello Maggiolini

Journal of Translational Medicine

Featured Section: ImmunoVirology and ImmunoOncology

Featured research: Spatial transcriptomics atlas reveals the crosstalk between cancer-associated fibroblasts and tumor microenvironment components in colorectal cancer

Featured review: Emerging role of human microbiome in cancer development and response to therapy

Articles

Chagasic cardiomyopathy is marked by a unique signature of activated CD4⁺ T cells

Evaluating the frequency and the impact of pharmacogenetic alleles in an ancestrally diverse Biobank population

Unilateral acute lung injury in pig: a promising animal model

Effects of hydrogen-rich saline in neuroinflammation and mitochondrial dysfunction in rat model of sepsis-associated encephalopathy

Comparison of clinical outcomes of frozen-thawed D5 and D6 blastocysts undergoing preimplantation genetic testing

Eating habits and lifestyle changes during COVID-19 lockdown: an Italian survey

Effects of eight weeks of time-restricted feeding (16/8) on basal metabolism, maximal strength, body composition, inflammation, and cardiovascular risk factors in resistance-trained males

Why tocilizumab could be an effective treatment for severe COVID-19?

Influence of diet on the gut microbiome and implications for human health

Neutrophil-to-lymphocyte ratio predicts critical illness patients with 2019 coronavirus disease in the early stage

Meet the Editors

Journal News

Editor Spotlight

^{Section: Combination Strategies}

Top trending articles

Our companion journal

Introducing new sections to Journal of Translational Medicine!

Cellular Metabolism Therapy

Translational Signaling and System Biology

Editor-in-Chief: Francesco Marincola, Kite Pharma, USA

Aims and scope

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