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Nutrition & metabolism

Section edited by Laura Soldati

This section aims to provide a platform for the interaction and mutual validation between basic and applied research in the field of nutrition. In the area of Translational Medicine, we believe that the field ought to be taken into greater account in order to generate advanced applications for diagnosis and therapy and, at the same time, to develop new instruments of investigation.

Studies on all aspects of nutrition and metabolism with applications in medicine and biotechnology will be considered for publication. The section not only welcomes contributions that employ traditional clinical, metabolic and epidemiologic methods, but is also interested in molecular and cell biology applied to human and animal nutrition.

Featured articles

Hericium erinaceus mycelium and its isolated erinacine A protection from MPTP-induced neurotoxicity through the ER stress, triggering an apoptosis cascade
Hsing-Chun Kuo, et al

Obesity and colorectal cancer: molecular features of adipose tissue
Javier Martinez-Useros and Jesus Garcia-Foncillas



Role of a polyphenol-enriched preparation on chemoprevention of mammary carcinoma through cancer stem cells and inflammatory pathways modulation
Tri Vuong, et al

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  1. Non-alcoholic fatty liver disease (NAFLD) is a metabolic disorder with abnormal lipid metabolism. The present study was to identify regulatory genes related to lipid droplets (LDs) abnormal accumulation in NAFLD.

    Authors: Zhiyong He, Yangyang Bin, Guangshun Chen, Qiang Li, Wenling Fan, Yongqiang Ma, Junfang Yi, Xiaohua Luo, Zhi Tan and Jiequn Li
    Citation: Journal of Translational Medicine 2022 20:529
  2. Identifying patterns of variation in obesity indices and other cardiometabolic risk factors before the diagnosis of type 2 diabetes could provide insight into the critical period when drastic changes occurred ...

    Authors: Fatemeh Koohi, Nooshin Ahmadi, Fereidoun Azizi, Davood Khalili and Majid Valizadeh
    Citation: Journal of Translational Medicine 2022 20:518
  3. Diabetic kidney disease (DKD) is among the most important causes for chronic kidney disease. Anthocyanins (ANT) are polyphenolic compounds present in various food and play an important role in ameliorating hyp...

    Authors: Yi-Xi Li, Yong-Ping Lu, Donge Tang, Bo Hu, Ze-Yu Zhang, Hong-Wei Wu, Li-Jing Fan, Kai-Wen Cai, Chun Tang, Yi-Qing Zhang, Ling Hong, Jing-jing Dong, Bao-zhang Guan, Liang-Hong Yin, Yong Dai, Wei-bin Bai…
    Citation: Journal of Translational Medicine 2022 20:510
  4. Apparent mineralocorticoid excess is an autosomal recessive form of monogenic disease characterized by juvenile resistant low-renin hypertension, marked hypokalemic alkalosis, low aldosterone levels, and high ...

    Authors: Yi-ting Lu, Di Zhang, Qiong-yu Zhang, Ze-ming Zhou, Kun-qi Yang, Xian-liang Zhou and Fan Peng
    Citation: Journal of Translational Medicine 2022 20:500
  5. This paper aimed to examine the effects of probiotics on eight factors in the prediabetic population by meta-analysis, namely, fasting blood glucose (FBG), glycated haemoglobin A1c (HbA1c), homeostatic model a...

    Authors: Ya Li, You Wu, Lili Wu, Lingling Qin and Tonghua Liu
    Citation: Journal of Translational Medicine 2022 20:498
  6. To explore the roles of Annexin A2 (ANXA2) on hepatocyte pyroptosis and hepatic fibrosis in nonalcoholic steatohepatitis (NASH) and underlying molecular mechanism.

    Authors: Yun Feng, Wenhua Li, Zhuoya Wang, Ruling Zhang, Yan Li, Lijuan Zang, Peiwen Wang, Zhenghong Li and Yuwei Dong
    Citation: Journal of Translational Medicine 2022 20:497
  7. Obesity (waist circumference, body mass index (BMI)) and lifestyle factors (dietary habits, smoking, alcohol drinking, Sedentary behavior) have been associated with risk of benign prostatic hyperplasia (BPH) i...

    Authors: Yong-Bo Wang, Lan Yang, Yu-Qing Deng, Si-Yu Yan, Li-Sha Luo, Ping Chen and Xian-Tao Zeng
    Citation: Journal of Translational Medicine 2022 20:495
  8. Osteoporosis (OP) is a systemic bone disease characterized by the decreased bone mass and destruction of bone microstructure, which tends to result in the enhanced bone fragility and related fractures, as well...

    Authors: Yuan-Wei Zhang, Mu-Min Cao, Ying-Juan Li, Xiang-Xu Chen, Qian Yu and Yun-Feng Rui
    Citation: Journal of Translational Medicine 2022 20:490
  9. Evidence about the relationship between triglyceride-to-high-density lipoprotein cholesterol (TG/HDL-C) ratio and prediabetes (Pre-DM) in Chinese non-obese people with a normal range of low-density lipoprotein...

    Authors: Liling Wu, Xiaodan Wu, Haofei Hu and Qijun Wan
    Citation: Journal of Translational Medicine 2022 20:484
  10. Proteinuria is an unfavorable clinical condition highly associated with a risk of renal and cardiovascular disease in chronic kidney disease (CKD). However, whether all proteinuria forms are linked to renal im...

    Authors: Chun Gan, Xindi Zhou, Dan Chen, Huan Chi, Jiawen Qiu, Hui You, Yaxi Chen, Mo Wang, Haiping Yang, Wei Jiang and Qiu Li
    Citation: Journal of Translational Medicine 2022 20:480
  11. The combined association of triglyceride-glucose (TyG) index and different systolic blood pressure (SBP) levels with all-cause and cardiovascular mortality among the general population remains unclear.

    Authors: Yu Yu, Min Gu, Hao Huang, Sijing Cheng, Yu Deng, Chi Cai, Xuhua Chen, Hongxia Niu, Xiaohui Ning and Wei Hua
    Citation: Journal of Translational Medicine 2022 20:478
  12. Nutritional assessment and quality of life (QOL) have become important indices for therapeutic efficacy in patients with malignancies. We aim to develop and validate an easy-to-use questionnaire with prognosti...

    Authors: Bingdong Zhang, Yuerui Li and Yongbing Chen
    Citation: Journal of Translational Medicine 2022 20:477
  13. Trimethylamine oxide (TMAO) is a biomarker in cardiovascular and renal diseases. TMAO originates from the oxidation of trimethylamine (TMA), a product of gut microbiota and manufacturing industries-derived pol...

    Authors: Klaudia M. Maksymiuk, Mateusz Szudzik, Marta Gawryś-Kopczyńska, Maksymilian Onyszkiewicz, Emilia Samborowska, Izabella Mogilnicka and Marcin Ufnal
    Citation: Journal of Translational Medicine 2022 20:470
  14. Probiotics have been defined as “living microorganisms that create health benefits in the host when taken in sufficient amounts. Recent developments in the understanding of the relationship between the microbi...

    Authors: Duygu Ağagündüz, Feray Gençer Bingöl, Elif Çelik, Özge Cemali, Çiler Özenir, Fatih Özoğul and Raffaele Capasso
    Citation: Journal of Translational Medicine 2022 20:460
  15. C1q/tumor necrosis factor-related protein 1 (CTRP1) is an adipokine secreted by adipose tissue, related to chondrocyte proliferation, inflammation, and glucose homeostasis. However, the therapeutic effects on ...

    Authors: Mingzhi Ren, Jianfei Pan, Xueying Yu, Kaile Chang, Xiaopeng Yuan and Chunbo Zhang
    Citation: Journal of Translational Medicine 2022 20:449
  16. Akkermansia muciniphila (A. muciniphila) is present in the human gut microbiota from infancy and gradually increases in adulthood. The potential impact of the abundance of A. muciniphila has been studied in major...

    Authors: Arun Prasath Lakshmanan, Selvasankar Murugesan, Souhaila Al Khodor and Annalisa Terranegra
    Citation: Journal of Translational Medicine 2022 20:430
  17. Diabetic kidney disease (DKD) is the leading cause of end-stage renal disease (ESRD) worldwide. SGLT2 inhibitors are clinically effective in halting DKD progression. However, the underlying mechanisms remain u...

    Authors: Yong-Ping Lu, Ze-Yu Zhang, Hong-Wei Wu, Li-Jing Fang, Bo Hu, Chun Tang, Yi-Qing Zhang, Lianghong Yin, Dong-E. Tang, Zhi-Hua Zheng, Ting Zhu and Yong Dai
    Citation: Journal of Translational Medicine 2022 20:420
  18. The association between body mass index (BMI) and Alzheimer's disease (AD) remains controversial. Genetic and environmental factors are now considered contributors to AD risk. However, little is known about th...

    Authors: Shiqi Yuan, Wentao Wu, Wen Ma, Xiaxuan Huang, Tao Huang, MIn Peng, Anding Xu and Jun Lyu
    Citation: Journal of Translational Medicine 2022 20:417
  19. Berberine (BBR), an isoquinoline alkaloid isolated from Rhizoma Coptis, is widely used in the treatment of hyperlipidemia (HLP) in China. At present, the efficacy of BBR against HLP is relatively clear, but th...

    Authors: Yuting Chen, Kaipeng Li, Han Zhao, Zhangsen Hao, Yuxin Yang, Mingming Gao and Ding Zhao
    Citation: Journal of Translational Medicine 2022 20:412
  20. Omega-3 may alleviate the severity of coronavirus disease 2019 (COVID-19) by reducing the C-reactive protein (CRP) level, a marker for systemic inflammation. Because the scientific evidence indicating such a r...

    Authors: Amira Mohamed Taha, Ahmad Shehata Shaarawy, Mohamed Mosad Omar, Khaled Abouelmagd, Noran Magdy Shalma, Mais Alhashemi, Hala Mahmoud Ahmed, Ahmed Hafez Allam and Mohamed Abd-ElGawad
    Citation: Journal of Translational Medicine 2022 20:401
  21. An imbalance in the expression of vascular endothelial growth factor (VEGF) and its receptor (VEGF-R) during pregnancy plays an important role in the pathogenesis of gestational diabetes mellitus (GDM) and ecl...

    Authors: Alayi Bolatai, Yujing He and Na Wu
    Citation: Journal of Translational Medicine 2022 20:400
  22. By identifying individuals at high risk for non-alcoholic fatty liver disease (NAFLD), interventional programs could be targeted more effectively. Some studies have demonstrated that triglyceride glucose-body ...

    Authors: Haofei Hu, Yong Han, Changchun Cao and Yongcheng He
    Citation: Journal of Translational Medicine 2022 20:398
  23. NorthCape4000 (NC4000) is the most participated ultra-endurance cycling race. Eight healthy male Caucasian amateur cyclists were evaluated: (a) before starting the preparation period; (b) in the week preceding...

    Authors: Maria Teresa Valenti, Michele Braggio, Arianna Minoia, Gianluigi Dorelli, Jessica Bertacco, Francesco Bertoldo, Mattia Cominacini, Tonia De Simone, Maria Grazia Romanelli, Lekhana Bhandary, Monica Mottes and Luca Dalle Carbonare
    Citation: Journal of Translational Medicine 2022 20:397
  24. The association between oral dysbiosis and chronic kidney disease (CKD) has gained increasing attention in recent years. Diabetes and hypertension are the most common conditions in CKD. However, a case–control...

    Authors: Fengping Liu, Jiayi Sheng, Lei Hu, Bin Zhang, Wei Guo, Yang Wang, Yifeng Gu, Peng Jiang, Hao Lin, Brako Lydia, Yifan Sun, Yifan Tang, Chaoqun Gu, Shichao Wei, Qixiao Zhai, Weiguo Chen…
    Citation: Journal of Translational Medicine 2022 20:387
  25. Recently, a few studies have indicated a relationship between the gut microbiota and IgA nephropathy (IgAN). Whether the gut microbiota participates in the pathogenesis of IgAN and whether probiotics are effec...

    Authors: Jiaxing Tan, Lingqiu Dong, Zheng Jiang, Li Tan, Xinyao Luo, Gaiqin Pei, Aiya Qin, Zhengxia Zhong, Xiang Liu, Yi Tang and Wei Qin
    Citation: Journal of Translational Medicine 2022 20:382
  26. Currently, there is no approved medication for non-alcoholic fatty liver disease management. Pre-clinical and clinical studies showed that several bioactive molecules in plants or foods (i.e., curcumin complex...

    Authors: Yvelise Ferro, Roberta Pujia, Elisa Mazza, Lidia Lascala, Oscar Lodari, Samantha Maurotti, Arturo Pujia and Tiziana Montalcini
    Citation: Journal of Translational Medicine 2022 20:377
  27. Adopting healthy lifestyles and staying mentally health are two cost-effective modifiable strategies that cancer survivors can implement in self-management. We aimed to evaluate the independent, mediation, int...

    Authors: Zhao-yan Liu, Chen Wang, Yao-jun Zhang and Hui-lian Zhu
    Citation: Journal of Translational Medicine 2022 20:376
  28. The role of trimethylamine-N-oxide (TMAO) in the development of diabetes remains controversial, and prospective data are few. We aimed to investigate the association between serum TMAO and incident type 2 diab...

    Authors: Shu-yi Li, Si Chen, Xiao-ting Lu, Ai-ping Fang, Yu-ming Chen, Rong-zhu Huang, Xin-lei Lin, Zi-hui Huang, Jing-fei Ma, Bi-xia Huang and Hui-lian Zhu
    Citation: Journal of Translational Medicine 2022 20:374
  29. There is limited evidence regarding the impact of pregnancy loss on the subsequent risk of metabolic disorders. We aimed to investigate whether history of pregnancy loss is associated with the subsequent risk ...

    Authors: Maryam Rahmati, Marzieh Saei Ghare Naz, Fereidoun Azizi and Fahimeh Ramezani Tehrani
    Citation: Journal of Translational Medicine 2022 20:372
  30. Primary hyperparathyroidism (PHPT) is mainly caused by parathyroid adenoma, which produces excess parathyroid hormones. Its pathogenic mechanisms have not yet been fully understood. To investigate the mechanis...

    Authors: Wen-Xuan Zhou, Shu Wang, Ting-Chao Wu, Ling-Chao Cheng, Yao Du, Wei Wu, Chen Lin, Xin-Ying Li and Zhong-Liang Hu
    Citation: Journal of Translational Medicine 2022 20:368
  31. To compare efficacy and safety of fecal microbiota transplantation (FMT) with glucocorticoid as induction therapy in ulcerative colitis (UC).

    Authors: Chunlan Huang, Zehua Huang, Ling Ding, Yang Fu, Junjie Fan, Qixiang Mei, Lihong Lou, Jingjing Wang, Nuoming Yin, Yingying Lu, Sanwei Guo and Yue Zeng
    Citation: Journal of Translational Medicine 2022 20:354
  32. Several studies suggest that dietary fiber intake may reduce mortality risk, but this might depend on the fiber types and the evidence regarding the role of soluble fiber or insoluble fiber on death risk remai...

    Authors: Xin Xu, Junmiao Zhang, Yanhui Zhang, Honggang Qi and Ping Wang
    Citation: Journal of Translational Medicine 2022 20:344
  33. NAFLD and NASH are emerging as primary causes of chronic liver disease, indicating a need for an effective treatment. Mutaflor® probiotic, a microbial treatment of interest, was effective in sustaining remissi...

    Authors: Noha M. Hany, Sanaa Eissa, Manal Basyouni, Amany H. Hasanin, Yasmin M. Aboul-Ela, Nagwa M. Abo Elmagd, Iman F. Montasser, Mahmoud A. Ali, Paul J. Skipp and Marwa Matboli
    Citation: Journal of Translational Medicine 2022 20:342
  34. Vascular endothelial growth factor B (VEGFB) was regarded to improve lipid metabolism and reduce obesity-related hyperlipidemia. Whether VEGFB participates in lipid metabolism in nonalcoholic fatty liver disea...

    Authors: Rongrong Li, Yuqi Li, Xueling Yang, Yaorui Hu, Haining Yu and Yana Li
    Citation: Journal of Translational Medicine 2022 20:341
  35. Physical independence is crucial for overall health in the elderly individuals. The life expectancy of women has been shown to be higher than that of men, which is also known as the “male–female health-surviva...

    Authors: Qiao Zhu, Ping Ping, Pei Zhang, Chaoxue Ning, Yali Zhao, Yao Yao, Xiubing Li and Shihui Fu
    Citation: Journal of Translational Medicine 2022 20:340
  36. Hyperkalemia is a common and potentially life-threatening electrolyte disorder in maintenance hemodialysis (MHD) patients. This study aimed to evaluate the efficacy and safety of potassium-lowering regimens du...

    Authors: Lan Yao, Xiaoyang Xing, Yubao Li, Fangxing Zhang, Ping Li, Xianhui Liang and Pei Wang
    Citation: Journal of Translational Medicine 2022 20:333
  37. The oral ecosystem conditions dental health, and is known to be positively modified by oral hygiene which cannot always be performed between meals, especially outside home. It is therefore important to identif...

    Authors: Erna Cecilia Lorenzini, Barbara Lazzari, Gianluca Martino Tartaglia, Giampietro Farronato, Valentina Lanteri, Sara Botti, Filippo Biscarini, Paolo Cozzi and Alessandra Stella
    Citation: Journal of Translational Medicine 2022 20:312
  38. The development of diabetes vascular calcification (VC) is tightly associated with the inhibition of vascular smooth muscle cell (VSMC) autophagy. Previously, our team found that miR-32-5p (miR-32) promotes ma...

    Authors: Jingsong Cao, Cong Chen, Qian Chen, Yan Gao, Zhibo Zhao, Qing Yuan, Anqi Li, Shiqi Yang, Yuqi He, Xuyu Zu and Jianghua Liu
    Citation: Journal of Translational Medicine 2022 20:307
  39. Nonalcoholic fatty liver disease (NAFLD) is one of the most common chronic liver diseases and has become a huge public health issue worldwide. Inhibition of nucleotide oligomerization domain-like receptors con...

    Authors: Chao Wu, Yanqin Bian, Bingjie Lu, Dan Wang, Nisma Lena Bahaji Azami, Gang Wei, Feng Ma and Mingyu Sun
    Citation: Journal of Translational Medicine 2022 20:294
  40. Bariatric surgery is an effective therapy for individuals with severe obesity to achieve sustainable weight loss and to reduce comorbidities. Examining the molecular signature of subcutaneous adipose tissue (S...

    Authors: Annie Bouchard-Mercier, Juan de Toro-Martín, Mélanie Nadeau, Odette Lescelleur, Stéfane Lebel, Denis Richard, Laurent Biertho, André Tchernof and Marie-Claude Vohl
    Citation: Journal of Translational Medicine 2022 20:283
  41. Adipose tissue homeostasis is at the heart of many metabolic syndromes such as diabetes. Previously it has been demonstrated that adipose tissues from diabetic patients are senescent but whether this contribut...

    Authors: Hao Lin, Xiaonan Chen, Jianan Pan, Jiahan Ke, Alian Zhang, Yangyang Liu, Changqian Wang, Alex Chia Yu Chang and Jun Gu
    Citation: Journal of Translational Medicine 2022 20:278
  42. Conventional and unconventional lipid parameters are associated with diabetes risk, the comparative studies on lipid parameters for predicting future diabetes risk, however, are still extremely limited, and th...

    Authors: Guotai Sheng, Maobin Kuang, Ruijuan Yang, Yanjia Zhong, Shuhua Zhang and Yang Zou
    Citation: Journal of Translational Medicine 2022 20:266
  43. Currently, remnant cholesterol (RC), lipoprotein(a) [Lp(a)], and inflammation are considered the principal residual cardiovascular risk (RCVR) factors. This study sought to evaluate the combined impact of RC, ...

    Authors: Hui-Hui Liu, Yuan-Lin Guo, Cheng-Gang Zhu, Na-Qiong Wu, Ying Gao, Rui-Xia Xu, Qian Dong, Jie Qian, Ke-Fei Dou and Jian-Jun Li
    Citation: Journal of Translational Medicine 2022 20:243
  44. Physical activity (PA) may protect against infertility by modulating the hypothalamic-pituitary–gonadal axis, thereby reducing gonadotropin levels, elevating immune function, and inhibiting inflammation and ci...

    Authors: Fangfang Xie, Yanli You, Chong Guan, Yuanjia Gu, Fei Yao and Jiatuo Xu
    Citation: Journal of Translational Medicine 2022 20:237
  45. Cardiometabolic disease (CMD) increases the risk of mortality, but the extent to which this can be offset by adherence to a healthy lifestyle is unknown. We aimed to investigate whether and to what extent a co...

    Authors: Chenjie Xu and Zhi Cao
    Citation: Journal of Translational Medicine 2022 20:234
  46. Familial hypercholesterolemia (FH) is a metabolic disease in which patients are prone to develop premature atherosclerosis (AS). Sorbin and SH3 Domain Containing 2 (SORBS2) is known to play a role in coronary ...

    Authors: Ming-Ming Liu, Jia Peng, Yuan-Lin Guo, Cheng-Gang Zhu, Na-Qiong Wu, Rui-Xia Xu, Qian Dong, Chuan-Jue Cui and Jian-Jun Li
    Citation: Journal of Translational Medicine 2022 20:233
  47. In 2010, November 16th, the Mediterranean diet was given the recognition of UNESCO as an “Intangible Heritage of Humanity” as this dietary pattern is rooted in the preservation of tradition, land, and biodiver...

    Authors: Annamaria Colao, Claudia Vetrani, Giovanna Muscogiuri, Luigi Barrea, Antonia Tricopoulou, Laura Soldati and Prisco Piscitelli
    Citation: Journal of Translational Medicine 2022 20:232
  48. Cigarette smoking (CS) is a strong risk factor for idiopathic pulmonary fibrosis (IPF). It can activate lung fibroblasts (LF) by inducing redox imbalance. We previously showed that clearing mitochondrial react...

    Authors: Yue Zhang, Ting Li, Miaoxia Pan, Wei Wang, Wenhui Huang, Yafei Yuan, Zhanzhan Xie, Yixin Chen, Jun Peng, Xu Li and Ying Meng
    Citation: Journal of Translational Medicine 2022 20:222
  49. Diabetic retinopathy (DR), especially proliferative diabetic retinopathy (PDR) is a common cause of blindness and visual impairment. Early prediction of its occurrence and progression is important to improved ...

    Authors: Huan Wang, Zhen Guo and Yu Xu
    Citation: Journal of Translational Medicine 2022 20:219

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