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Nutrition & Metabolism

Section edited by Laura Soldati

This section aims to provide a platform for the interaction and mutual validation between basic and applied research in the field of nutrition. In the area of Translational Medicine, we believe that the field ought to be taken into greater account in order to generate advanced applications for diagnosis and therapy and, at the same time, to develop new instruments of investigation.

Studies on all aspects of nutrition and metabolism with applications in medicine and biotechnology will be considered for publication. The section not only welcomes contributions that employ traditional clinical, metabolic and epidemiologic methods, but is also interested in molecular and cell biology applied to human and animal nutrition.

Featured articles

Hericium erinaceus mycelium and its isolated erinacine A protection from MPTP-induced neurotoxicity through the ER stress, triggering an apoptosis cascade
Hsing-Chun Kuo, et al

Obesity and colorectal cancer: molecular features of adipose tissue
Javier Martinez-Useros and Jesus Garcia-Foncillas



Role of a polyphenol-enriched preparation on chemoprevention of mammary carcinoma through cancer stem cells and inflammatory pathways modulation
Tri Vuong, et al

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  1. The Mediterranean Diet (MD) has garnered increasing attention for its potential protective effects against gastric cancer (GC). The MD’s rich content of antioxidants, polyphenols, and other bioactive compounds...

    Authors: Claudia Reytor-González, Ana Karina Zambrano, Martha Montalvan, Evelyn Frias-Toral, Alison Simancas-Racines and Daniel Simancas-Racines
    Citation: Journal of Translational Medicine 2024 22:483
  2. The measurement of the skin carotenoids using the Veggie Meter® has emerged as a rapid objective method for assessing fruit and vegetable intake, highly recommended by the Mediterranean Diet (MD), which repres...

    Authors: Giuseppina Augimeri, Manuel Soto, Fabrizio Ceraudo, Giovanna Caparello, Melisa Villegas Figueroa, Mirko Cesario, Lorenzo S. Caputi, Berniza Calderón and Daniela Bonofiglio
    Citation: Journal of Translational Medicine 2024 22:424
  3. The Mediterranean diet (MedDiet) is a widely studied dietary pattern reflecting the culinary traditions of Mediterranean regions. High adherence to MedDiet correlates with reduced blood pressure and lower card...

    Authors: Ana Karina Zambrano, Santiago Cadena-Ullauri, Viviana A. Ruiz-Pozo, Rafael Tamayo-Trujillo, Elius Paz-Cruz, Patricia Guevara-Ramírez, Evelyn Frias-Toral and Daniel Simancas-Racines
    Citation: Journal of Translational Medicine 2024 22:417
  4. Quinic acid (QA) and its derivatives have good lipid-lowering and hepatoprotective functions, but their role in atherosclerosis remains unknown. This study attempted to investigate the mechanism of QA on ather...

    Authors: Qiao Jin, Chiyuan Zhang, Ran Chen, Luping Jiang, Hongli Li, Pengcui Wu and Liang Li
    Citation: Journal of Translational Medicine 2024 22:352
  5. The COVID-19 pandemic caused societal disruption in the United States and most of the world, affecting many aspects of life, including healthcare and health-related behaviors such as diet, food security, and p...

    Authors: Giovanna Muscogiuri, Lindsay Kohler, Oscar Parra, Lisa Soltani, Douglas Spegman, Dawn Coletta and Lawrence J. Mandarino
    Citation: Journal of Translational Medicine 2024 22:342
  6. Acne, a chronic inflammatory disease impacting the pilosebaceous unit, is influenced significantly by inflammation and oxidative stress, and is commonly associated with obesity. Similarly, obesity is also asso...

    Authors: Ludovica Verde, Evelyn Frias-Toral, Sara Cacciapuoti, Daniel Simancas-Racines, Matteo Megna, Giuseppina Caiazzo, Luca Potestio, Maria Maisto, Gian Carlo Tenore, Annamaria Colao, Silvia Savastano, Giovanna Muscogiuri and Luigi Barrea
    Citation: Journal of Translational Medicine 2024 22:322
  7. Dihydromyricetin (DHM), a flavonoid compound of natural origin, has been identified in high concentrations in ampelopsis grossedentata and has a broad spectrum of biological and pharmacological functions, particu...

    Authors: Yan Yang, Wen Qiu, Jiyuan Xiao, Jie Sun, Xuan Ren and Luxia Jiang
    Citation: Journal of Translational Medicine 2024 22:309
  8. Ulcerative colitisis (UC) classified as a form of inflammatory bowel diseases (IBD) characterized by chronic, nonspecific, and recurrent symptoms with a poor prognosis. Common clinical manifestations of UC inc...

    Authors: Fazheng Yu, Xueyu Hu, HongLin Ren, Xiaoxu Wang, Ruoran Shi, Jian Guo, Jiang Chang, Xiaoshi Zhou, Yuanyuan Jin, Yansong Li, Zengshan Liu and Pan Hu
    Citation: Journal of Translational Medicine 2024 22:308
  9. Over the last decades, the Mediterranean diet gained enormous scientific, social, and commercial attention due to proven positive effects on health and undeniable taste that facilitated a widespread popularity...

    Authors: Justyna Godos, Francesca Scazzina, Corrado Paternò Castello, Francesca Giampieri, José L. Quiles, Mercedes Briones Urbano, Maurizio Battino, Fabio Galvano, Licia Iacoviello, Giovanni de Gaetano, Marialaura Bonaccio and Giuseppe Grosso
    Citation: Journal of Translational Medicine 2024 22:294
  10. Angiopoietin-like protein 3 (ANGPTL3) is secreted by hepatocytes and inhibits lipoprotein lipase and endothelial lipase activity. Previous studies reported the correlation between plasma ANGPTL3 levels and hig...

    Authors: Longyan Yang, Yan Wang, Yongsong Xu, Kun Li, Ruili Yin, Lijie Zhang, Di Wang, Lingling Wei, Jianan Lang, Yanan Cheng, Lu Wang, Jing Ke and Dong Zhao
    Citation: Journal of Translational Medicine 2024 22:263
  11. Albuminuria, the presence of excess of protein in urine, is a well-known risk factor for early kidney damage among diabetic/prediabetic patients. There is a complex interaction between physical activity (PA) a...

    Authors: Bingquan Xiong, Yufan Wang, Juan He, Lisha Wang, Rui He, Min Zhu, Jiaxing Wang, Yingrui Li, Bin Liu, Kaihu Xiao and Qiang She
    Citation: Journal of Translational Medicine 2024 22:252
  12. Flavonoids are a class of secondary plant metabolites that have been shown to have multiple health benefits, including antioxidant and anti-inflammatory. This study was to explore the association between dieta...

    Authors: Runmiao Wu, Xu Zhu, Gongchang Guan, Qianwei Cui, Ling Zhu, Yujie Xing and Jingsha Zhao
    Citation: Journal of Translational Medicine 2024 22:205
  13. Metabolic and bariatric surgery (MBS) is safe and efficacious in treating adolescents with severe obesity. Behavioral/lifestyle programs can support successful preparation for surgery and post-MBS weight loss,...

    Authors: Maral Misserian, Alicia Wheelington, Rashon King, Jackson Francis, M. Sunil Mathew, Marlyn A. Allicock, Bethany R. Cartwright, Adejumoke Adewunmi, Aparajita Chandrasekhar, Dhatri Polavarapu, Faisal G. Qureshi, Sarah E. Barlow and Sarah E. Messiah
    Citation: Journal of Translational Medicine 2024 22:197
  14. The morbidity of gestational diabetes mellitus (GDM) is increasing and is associated with adverse perinatal outcomes and long-term maternal and infant health. The exact mechanism underlying changes in plasma f...

    Authors: Haoyi Du, Danyang Li, Laura Monjowa Molive and Na Wu
    Citation: Journal of Translational Medicine 2024 22:180
  15. Proximal tubular cells (PTCs) play a critical role in the progression of diabetic kidney disease (DKD). As one of important progenitor markers, CD133 was reported to indicate the regeneration of dedifferentiat...

    Authors: Yuhan Zhang, Lusi Xu, Congcong Guo, Xianzhi Li, Yutian Tian, Lin Liao and Jianjun Dong
    Citation: Journal of Translational Medicine 2024 22:159
  16. Hidradenitis suppurativa (HS), an inflammatory-based dermatological condition often associated with obesity, poses significant challenges in management. The very low-calorie ketogenic diet (VLCKD) has shown ef...

    Authors: Ludovica Verde, Sara Cacciapuoti, Giuseppina Caiazzo, Matteo Megna, Fabrizio Martora, Annarita Cavaliere, Maria Mattera, Maria Maisto, Gian Carlo Tenore, Annamaria Colao, Silvia Savastano, Giovanna Muscogiuri and Luigi Barrea
    Citation: Journal of Translational Medicine 2024 22:149
  17. Excessive energy intake in modern society has led to an epidemic surge in metabolic diseases, such as obesity and type 2 diabetes, posing profound threats to women’s reproductive health. However, the precise i...

    Authors: Congcong Liu, Yunde Dou, Mengge Zhang, Shan Han, Shourui Hu, Yuxuan Li, Zhiheng Yu, Yue Liu, Xiaofan Liang, Zi-Jiang Chen, Han Zhao and Yuqing Zhang
    Citation: Journal of Translational Medicine 2024 22:145
  18. Bone is a metabolically active tissue containing different cell types acting as endocrine targets and effectors. Further, bone is a dynamic depot for calcium, phosphorous and other essential minerals. The tiss...

    Authors: Amir Mohammad Malvandi, Esra Halilaj, Martina Faraldi, Laura Mangiavini, Simone Cristoni, Valerio Leoni and Giovanni Lombardi
    Citation: Journal of Translational Medicine 2024 22:143

    The Correction to this article has been published in Journal of Translational Medicine 2024 22:303

  19. Overweight is known to be an important risk factor for colorectal cancer (CRC), and the differences in intestinal flora among CRC patients with different BMI status have not been clearly defined. The purpose o...

    Authors: Yongqi Huang, Xiaoliang Huang, Zhen Wang, Fuhai He, Zigui Huang, Chuanbin Chen, Binzhe Tang, Mingjian Qin, Yongzhi Wu, Chenyan Long, Weizhong Tang, Xianwei Mo and Jungang Liu
    Citation: Journal of Translational Medicine 2024 22:142
  20. Overweight and obesity are established risk factors for various types of cancers including colorectal cancer (CRC). However the underlying molecular mechanisms remain unclear. An in-depth understanding of the ...

    Authors: Guozhong Xiao, Yihui Zheng, Huaxian Chen, Minyi Luo, Chaoxin Yang, Donglin Ren, Pengfei Qin, Heng Zhang and Hongcheng Lin
    Citation: Journal of Translational Medicine 2024 22:134
  21. Vitamin D (VD) is implicated in various health conditions, including colorectal cancer (CRC). To investigate potential relationships between pre-chemotherapy VD levels and the time-to-outcome in metastatic CRC...

    Authors: Alessandro Ottaiano, Maria Lucia Iacovino, Mariachiara Santorsola, Sergio Facchini, Domenico Iervolino, Francesco Perri, Guglielmo Nasti, Vincenzo Quagliariello, Nicola Maurea, Andrea Ronchi, Bianca Arianna Facchini, Alessia Bignucolo and Massimiliano Berretta
    Citation: Journal of Translational Medicine 2024 22:119
  22. Converging data have suggested that monocytic inflammation and C-reactive protein (CRP) are biologically intertwined processes and are involved in diabetogenesis. This study aimed to investigate the associatio...

    Authors: Dan Wu, Genyuan Chen, Yulong Lan, Shuohua Chen, Xiong Ding, Chiju Wei, Lois Balmer, Wei Wang, Shouling Wu and Wencan Xu
    Citation: Journal of Translational Medicine 2024 22:110
  23. Atherosclerosis is a chronic, progressive, inflammatory disease that occurs in the arterial wall. Despite recent advancements in treatment aimed at improving efficacy and prolonging survival, atherosclerosis r...

    Authors: Huiling Lin, Ming Zhang, Mi Hu, Yangkai Zhang, WeiWei Jiang, Wanying Tang, Yuxin Ouyang, Liping Jiang, Yali Mi, Zhi Chen, Pingping He, Guojun Zhao and Xinping Ouyang
    Citation: Journal of Translational Medicine 2024 22:97
  24. Obesity, a condition associated with the development of widespread cardiovascular disease, metabolic disorders, and other health complications, has emerged as a significant global health issue. Oleanolic acid ...

    Authors: Tianfeng Liu, Jiliang Wang, Ying Tong, Lele Wu, Ying Xie, Ping He, Shujue Lin and Xuguang Hu
    Citation: Journal of Translational Medicine 2024 22:86
  25. Mediterranean Diet (MD) has many health benefits, particularly in reducing cardiovascular risk (CVR). However, it is still little known if there are any sex differences in following this nutritional pattern an...

    Authors: Luigi Barrea, Ludovica Verde, Rosario Suárez, Evelyn Frias-Toral, Celina Andrade Vásquez, Annamaria Colao, Silvia Savastano and Giovanna Muscogiuri
    Citation: Journal of Translational Medicine 2024 22:44
  26. Dietary sulfur amino acid restriction (SAAR) improves metabolic health in animals. In this study, we investigated the effect of dietary SAAR on body weight, body composition, resting metabolic rate, gene expre...

    Authors: Thomas Olsen, Emma Stolt, Bente Øvrebø, Amany Elshorbagy, Elena C. Tore, Sindre Lee-Ødegård, Hannibal Troensegaard, Hanna Johannessen, Beate Doeland, Anna A. D. Vo, Anja F. Dahl, Karianne Svendsen, Magne Thoresen, Helga Refsum, Russell Rising, Kristýna Barvíková…
    Citation: Journal of Translational Medicine 2024 22:40
  27. Patients with type 2 diabetes mellitus (T2DM) are at higher risk of developing atherosclerosis. Previous studies have analyzed the factors associated with diabetic macrovascular disease, although whether these...

    Authors: Jin Chen, Wenwen Li, Jingzhu Cao, Yuhan Lu, Chaoqun Wang and Jin Lu
    Citation: Journal of Translational Medicine 2024 22:18
  28. Pain is a worldwide problem requiring an effective, affordable, non-addictive therapy. Using the edible plant broccoli, a growth protocol was developed to induce a concentrated combinatorial of potential anti-...

    Authors: Aleksandra A. Gurgul, Yahya Najjar, Ana Chee, Howard An, Chun-Tao Che, Thomas J. Park and Katherine M. Warpeha
    Citation: Journal of Translational Medicine 2023 21:922
  29. Previous studies have demonstrated that high-density lipoprotein cholesterol (HDL-C) plays an anti-atherosclerosis role through reverse cholesterol transport. Several studies have validated the efficacy and sa...

    Authors: Yilin Chen, Fengwei Zhang, Jijia Sun and Lei Zhang
    Citation: Journal of Translational Medicine 2023 21:920
  30. Bioelectrical impedance analysis (BIA) is a rapid and user-friendly technique for assessing body composition in sports. Currently, no sport-specific predictive equations are available, and the utilization of g...

    Authors: Francesco Campa, Tindaro Bongiovanni, Alessio Rossi, Giuseppe Cerullo, Andrea Casolo, Giulia Martera, Athos Trecroci, Tatiana Moro and Antonio Paoli
    Citation: Journal of Translational Medicine 2023 21:912
  31. Obesity, characterized by visceral adipose tissue (VAT) expansion, is closely associated with metabolic dysfunction-associated steatotic liver disease (MASLD) and metabolic dysfunction-associated steatohepatit...

    Authors: Noel Salvoza, Pablo Giraudi, Silvia Gazzin, Deborah Bonazza, Silvia Palmisano, Nicolò de Manzini, Fabrizio Zanconati, Alan Raseni, Francesca Sirianni, Claudio Tiribelli and Natalia Rosso
    Citation: Journal of Translational Medicine 2023 21:906
  32. The consumption of various herbal infusions was and is common in the traditional Mediterranean diet, and apparently are used in many other regions of the world outside of the Mediterranean region. The present ...

    Authors: Ekaterina-Michaela Tomou, Eleni Peppa and Antonia Trichopoulou
    Citation: Journal of Translational Medicine 2023 21:899
  33. The current body of evidence on the association between the ratio of triglycerides to high-density lipoprotein cholesterol (TG/HDL-c) and the reversal of prediabetes to normoglycemia remains limited. The aim o...

    Authors: Zhiqiang Huang, Yong Han, Haofei Hu, Changchun Cao, Dehong Liu and Zhibin Wang
    Citation: Journal of Translational Medicine 2023 21:868
  34. Psoriasis is a chronic inflammatory skin disease with metabolic abnormalities serving as important contributors for pathogenesis and progression. Polyunsaturated fatty acids (PUFAs) have been found to be assoc...

    Authors: Xin Wang, Rui Ma, Rongcan Shi, Hui Qin, Wenjuan Chen, Zengyang Yu, Yangfeng Ding, Chen Peng and Yuling Shi
    Citation: Journal of Translational Medicine 2023 21:834
  35. Med-Index is a one-health front-of-pack (FOP) label, based on Mediterranean diet (MedDiet) principles, developed to summarize information about the nutritional properties and related-health benefits of any foo...

    Authors: Roberta Zupo, Fabio Castellana, Prisco Piscitelli, Pasquale Crupi, Addolorata Desantis, Enrico Greco, Franca Paola Severino, Manuela Pulimeno, Andrea Guazzini, Tassos C. Kyriakides, Vasilis Vasiliou, Antonia Trichopoulou, Laura Soldati, Carlo La Vecchia, Giovanni De Gaetano, Maria Benedetta Donati…
    Citation: Journal of Translational Medicine 2023 21:755
  36. The available evidence indicates that the severity of metabolic syndrome tends to worsen progressively over time. We assessed the trajectory of age and sex-specific continuous MetS severity score (cMetS-S) and...

    Authors: Atieh Amouzegar, Mohammadjavad Honarvar, Safdar Masoumi, Davood Khalili, Fereidoun Azizi and Ladan Mehran
    Citation: Journal of Translational Medicine 2023 21:750
  37. This study aimed to develop a simplified diagnostic tool for assessing sarcopenia and myosteatosis in gastrointestinal cancer patients, focusing on the creatinine to cystatin C ratio (CCR) as an evaluation mar...

    Authors: Hao Liu, Junjie Wang, Shanjun Tan, Zhige Zhang, Mingyue Yan, Jun Han, Xiangyu Sui, Fan Yang and Guohao Wu
    Citation: Journal of Translational Medicine 2023 21:744
  38. Changes in the gut microbiota composition is a hallmark of chronic kidney disease (CKD), and interventions targeting the gut microbiota present a potent approach for CKD treatment. This study aimed to evaluate...

    Authors: Hao-Jie Zhong, Xinqiang Xie, Wen-Jia Chen, Yu-Pei Zhuang, Xuan Hu, Ying-Li Cai, Hong-Lie Zeng, Chuanxing Xiao, Ying Li, Yu Ding, Liang Xue, Moutong Chen, Jumei Zhang, Qingping Wu and Xing-Xiang He
    Citation: Journal of Translational Medicine 2023 21:740
  39. Whether serum vitamin D mediate vascular diseases in prediabetic populations remains unclear. This study aimed to determine the associations between circulating 25-hydroxyvitamin D [25(OH)D] levels and vitamin...

    Authors: Pingting Zhong, Zhuoting Zhu, Yunlong Wang, Wenyong Huang, Mingguang He and Wei Wang
    Citation: Journal of Translational Medicine 2023 21:724
  40. Early-stage detection of chronic kidney diseases (CKD) is important to treatment that may slow and occasionally halt CKD progression. CKD of diverse etiologies share similar histologic patterns of glomeruloscl...

    Authors: Colleen S. Curran and Jeffrey B. Kopp
    Citation: Journal of Translational Medicine 2023 21:706
  41. The increasing prevalence of metabolic and cardiovascular diseases poses a significant challenge to global healthcare systems. Regular physical activity (PA) is recognized for its positive impact on cardiovasc...

    Authors: Chang Sheng, Weihua Huang, Wei Wang, Guoqiang Lin, Mingmei Liao and Pu Yang
    Citation: Journal of Translational Medicine 2023 21:705
  42. Non-alcoholic fatty liver disease (NAFLD) is a common liver disease increasing cardiovascular disease (CVD) morbidity and mortality. Autoantibodies against apolipoprotein A-1 (AAA-1) are a possible novel CVD r...

    Authors: Sabrina Pagano, Stephan J. L. Bakker, Catherine Juillard, Stefania Vossio, Dimitri Moreau, Karim J. Brandt, François Mach, Robin P. F. Dullaart and Nicolas Vuilleumier
    Citation: Journal of Translational Medicine 2023 21:694
  43. Migraine is the second world’s cause of disability. Among non-pharmacological treatments, nutritional intervention, particularly ketogenic diet, represents one of the most promising approaches.

    Authors: Massimiliano Caprio, Eleonora Moriconi, Elisabetta Camajani, Alessandra Feraco, Vincenzo Marzolla, Laura Vitiello, Stefania Proietti, Andrea Armani, Stefania Gorini, Caterina Mammi, Gabriella Egeo, Cinzia Aurilia, Giulia Fiorentini, Carlo Tomino and Piero Barbanti
    Citation: Journal of Translational Medicine 2023 21:692
  44. Metabolic syndrome (MetS), a worldwide public health problem, affects human health and quality of life in a dramatic manner. A growing evidence base suggests that MetS is strongly associated with levels of sys...

    Authors: Yang Zhao, Wenyu Shao, Qihan Zhu, Rui Zhang, Tao Sun, Bijia Wang and Xiaofei Hu
    Citation: Journal of Translational Medicine 2023 21:691
  45. There is little prospective evidence exists about whether adherence to a diabetes risk reduction diet (DRRD) is related to a significant reduction in renal cancer risk. We sought to clarify whether adherence t...

    Authors: Ling Xiang, Yi Xiao, Zhiquan Xu, Haoyun Luo, Xiaorui Ren, Qi Wei, Zhiyong Zhu, Yahui Jiang, Yunhao Tang, Hongmei He, Zhihang Zhou, Haitao Gu, Yaxu Wang and Linglong Peng
    Citation: Journal of Translational Medicine 2023 21:684
  46. Previous studies have assessed the association between antidiabetic drugs and stroke risk, but the results are inconsistent. Mendelian randomization (MR) was used to assess effects of antidiabetic drugs on str...

    Authors: Yahui Zhu, Mao Li, Hongfen Wang, Fei Yang, Xinyuan Pang, Rongrong Du, Jinghong Zhang and Xusheng Huang
    Citation: Journal of Translational Medicine 2023 21:681
  47. Plant-based dietary patterns may affect colorectal cancer (CRC) related outcomes, while risks differ in the quality of plant foods. We aimed to examine the association of plant-based diet quality with risks of...

    Authors: Fubin Liu, Yanling Lv, Yu Peng, Yating Qiao, Peng Wang, Changyu Si, Xixuan Wang, Jianxiao Gong, Huijun Zhou, Ming Zhang, Liangkai Chen and Fangfang Song
    Citation: Journal of Translational Medicine 2023 21:669

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