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Nutrition & metabolism

Section edited by Laura Soldati

This section aims to provide a platform for the interaction and mutual validation between basic and applied research in the field of nutrition. In the area of Translational Medicine, we believe that the field ought to be taken into greater account in order to generate advanced applications for diagnosis and therapy and, at the same time, to develop new instruments of investigation.

Studies on all aspects of nutrition and metabolism with applications in medicine and biotechnology will be considered for publication. The section not only welcomes contributions that employ traditional clinical, metabolic and epidemiologic methods, but is also interested in molecular and cell biology applied to human and animal nutrition.

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  1. Content type: Research

    DNA methylation has been evidenced as a potential epigenetic mechanism related to various candidate genes to development of obesity. Therefore, the objective of this study was to evaluate the DNA methylation l...

    Authors: Yohanna de Oliveira, Raquel Patrícia Ataíde Lima, Rafaella Cristhine Pordeus Luna, Mussara Gomes Cavalcanti Alves Monteiro, Cássia Surama Oliveira da Silva, Rayner Anderson Ferreira do Nascimento, Keylha Querino de Farias Lima, Ana Hermínia Andrade e Silva, Flávia Emília Leite de Lima Ferreira, Rodrigo Pinheiro de Toledo Vianna, Ronei Marcos de Moraes, Naila Francis Paulo de Oliveira, Aléssio Tony Cavalcanti de Almeida, Alexandre Sérgio Silva, Alcides da Silva Diniz, Maria José de Carvalho Costa…

    Citation: Journal of Translational Medicine 2018 16:152

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  2. Content type: Research

    Chronic respiratory diseases, whose one of the hallmarks is oxidative stress, are still incurable and need novel therapeutic tools and pharmaceutical agents. The phenolic compounds contained in grape are endow...

    Authors: S. Castellani, A. Trapani, A. Spagnoletta, L. di Toma, T. Magrone, S. Di Gioia, D. Mandracchia, G. Trapani, E. Jirillo and M. Conese

    Citation: Journal of Translational Medicine 2018 16:140

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  3. Content type: Review

    Immunotherapy has matured into standard treatment for several cancers, but much remains to be done to extend the reach of its effectiveness particularly to cancers that are resistant within each indication. Th...

    Authors: Laura Soldati, Laura Di Renzo, Emilio Jirillo, Paolo A. Ascierto, Francesco M. Marincola and Antonino De Lorenzo

    Citation: Journal of Translational Medicine 2018 16:75

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  4. Content type: Review

    Extensive research within the last several decades has revealed that the major risk factors for most chronic diseases are infections, obesity, alcohol, tobacco, radiation, environmental pollutants, and diet. I...

    Authors: Ajaikumar B. Kunnumakkara, Bethsebie L. Sailo, Kishore Banik, Choudhary Harsha, Sahdeo Prasad, Subash Chandra Gupta, Alok Chandra Bharti and Bharat B. Aggarwal

    Citation: Journal of Translational Medicine 2018 16:14

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  5. Content type: Research

    Numerous studies have investigated the role of the monounsaturated fatty acid and other dietary factors in the prevention of cognitive decline but the short-term effect of a low dose of extravirgin olive oil o...

    Authors: Elisa Mazza, Antonietta Fava, Yvelise Ferro, Stefania Rotundo, Stefano Romeo, Domenico Bosco, Arturo Pujia and Tiziana Montalcini

    Citation: Journal of Translational Medicine 2018 16:10

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  6. Content type: Research

    The present randomized clinical trial characterized the beneficial effects of a multi-strain probiotics supplementation on improving circulating endotoxin levels (primary endpoint) and other cardiometabolic bi...

    Authors: Shaun Sabico, Ayah Al-Mashharawi, Nasser M. Al-Daghri, Sobhy Yakout, Abdullah M. Alnaami, Majed S. Alokail and Philip G. McTernan

    Citation: Journal of Translational Medicine 2017 15:249

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  7. Content type: Research

    Adipocytes derived from human mesenchymal stem cells (MSCs) are widely used to investigate adipogenesis. Taking into account both the novelty of these MSCs and the scarcity of studies focused on the effects of...

    Authors: Saioa Gómez-Zorita, Arrate Lasa, Naiara Abendaño, Alfredo Fernández-Quintela, Andrea Mosqueda-Solís, Maria Pilar Garcia-Sobreviela, Jose M. Arbonés-Mainar and Maria P. Portillo

    Citation: Journal of Translational Medicine 2017 15:237

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  8. Content type: Research

    Chronic inflammation is a predisposing factor to numerous degenerative diseases including cancer, heart failure and Alzheimer’s disease. Infla-Kine is a natural supplement comprised of a proprietary blend of Lact...

    Authors: Nina A. Mikirova, Santosh Kesari, Thomas E. Ichim and Neil H. Riordan

    Citation: Journal of Translational Medicine 2017 15:213

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  9. Content type: Research

    Different lines of evidence suggest that oxidative stress (OS) is implicated in the pathogenesis of diabetic neuropathy. The Semmes–Weinstein monofilament (SWM) test is an efficient tool for evaluating diabeti...

    Authors: Sergio Martinez-Hervás, Mercedes Molina Mendez, José Folgado, Carmen Tormos, Pilar Ascaso, Marta Peiró, Jose T. Real and Juan F. Ascaso

    Citation: Journal of Translational Medicine 2017 15:187

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  10. Content type: Research

    Evidence of probiotics effects on gut function, brain activity and emotional behaviour were provided. Probiotics can have dramatic effects on behaviour through the microbiome–gut–brain axis, through vagus nerv...

    Authors: Antonino De Lorenzo, Micaela Costacurta, Giuseppe Merra, Paola Gualtieri, Giorgia Cioccoloni, Massimiliano Marchetti, Dimitrios Varvaras, Raffaella Docimo and Laura Di Renzo

    Citation: Journal of Translational Medicine 2017 15:135

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  11. Content type: Research

    Betaine (BET), a component of many foods, is an essential osmolyte and a source of methyl groups; it also shows an antioxidant activity. Moreover, BET stimulates muscle differentiation via insulin like growth ...

    Authors: Isabella Villa, Pamela Senesi, Anna Montesano, Anita Ferraretto, Fernanda Vacante, Alice Spinello, Michela Bottani, Simona Bolamperti, Alessandro Rubinacci, Livio Luzi and Ileana Terruzzi

    Citation: Journal of Translational Medicine 2017 15:132

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  12. Content type: Research article

    Standardized animal-free components are required for manufacturing cell-based medicinal products. Human platelet concentrates are sources of growth factors for cell expansion but such products are characterize...

    Authors: Francesco Agostini, Jerry Polesel, Monica Battiston, Elisabetta Lombardi, Stefania Zanolin, Alessandro Da Ponte, Giuseppe Astori, Cristina Durante and Mario Mazzucato

    Citation: Journal of Translational Medicine 2017 15:107

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  13. Content type: Research

    Nutrition is an environmental factor affecting bone health. Nutrition is considered essential to achieve and maintain optimal bone mass. Mediterranean diet (MD) has shown to prevent bone disease. Aim of this s...

    Authors: Maria Cristina Savanelli, Luigi Barrea, Paolo Emidio Macchia, Silvia Savastano, Andrea Falco, Andrea Renzullo, Elisabetta Scarano, Immacolata Cristina Nettore, Annamaria Colao and Carolina Di Somma

    Citation: Journal of Translational Medicine 2017 15:81

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  14. Content type: Review

    Recent studies have suggested that the intestinal microbiome plays an important role in modulating risk of several chronic diseases, including inflammatory bowel disease, obesity, type 2 diabetes, cardiovascul...

    Authors: Rasnik K. Singh, Hsin-Wen Chang, Di Yan, Kristina M. Lee, Derya Ucmak, Kirsten Wong, Michael Abrouk, Benjamin Farahnik, Mio Nakamura, Tian Hao Zhu, Tina Bhutani and Wilson Liao

    Citation: Journal of Translational Medicine 2017 15:73

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  15. Content type: Research

    Replacing glucose with a better biocompatible osmotic agent in peritoneal dialysis (PD) solutions is needed in PD clinic. We previously demonstrated the potential of hyperbranched polyglycerol (HPG) as a repla...

    Authors: Caigan Du, Asher A. Mendelson, Qiunong Guan, Ghida Dairi, Irina Chafeeva, Gerald da Roza and Jayachandran N. Kizhakkedathu

    Citation: Journal of Translational Medicine 2016 14:338

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  16. Content type: Research

    Intermittent fasting (IF) is an increasingly popular dietary approach used for weight loss and overall health. While there is an increasing body of evidence demonstrating beneficial effects of IF on blood lipi...

    Authors: Tatiana Moro, Grant Tinsley, Antonino Bianco, Giuseppe Marcolin, Quirico Francesco Pacelli, Giuseppe Battaglia, Antonio Palma, Paulo Gentil, Marco Neri and Antonio Paoli

    Citation: Journal of Translational Medicine 2016 14:290

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  17. Content type: Research

    Vitamin D (VitD) and thymoquinone (TQ) are nutraceutical agents with well-known immunomodulatory and hepatoprotective properties. This study measured whether VitD and TQ, individually or combined, could have d...

    Authors: Abdelghany Hassan Abdelghany, Mohammad A. BaSalamah, Shakir Idris, Jawwad Ahmad and Bassem Refaat

    Citation: Journal of Translational Medicine 2016 14:281

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  18. Content type: Research

    Moniliformediquinone (MFD), a phenanthradiquinone in Dendrobium moniliforme, was synthesized in our laboratory. Beyond its in vitro inhibitory effects on cancer cells, other biological activity of MFD is unknown....

    Authors: Tsui-Hwa Tseng, Wea-Lung Lin, Zi-Hui Chen, Yean-Jang Lee, Ming-Shiun Shie, Kam-Fai Lee, Chien-Heng Shen and Hsing-Chun Kuo

    Citation: Journal of Translational Medicine 2016 14:263

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  19. Content type: Research

    Body mass index (BMI), waist circumference (WC), visceral adiposity index (VAI), triglyceride glucose index (TyG), TyG-BMI, and TyG-WC have been reported as markers of insulin resistance or type 2 diabetes mel...

    Authors: Shuang Zheng, Sheng Shi, Xingxing Ren, Tingting Han, Yangxue Li, Yawen Chen, Wei Liu, Peter C. Hou and Yaomin Hu

    Citation: Journal of Translational Medicine 2016 14:260

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