Nutrition & metabolism

Section edited by Laura Soldati

This section aims to provide a platform for the interaction and mutual validation between basic and applied research in the field of nutrition. In the area of Translational Medicine, we believe that the field ought to be taken into greater account in order to generate advanced applications for diagnosis and therapy and, at the same time, to develop new instruments of investigation.

Studies on all aspects of nutrition and metabolism with applications in medicine and biotechnology will be considered for publication. The section not only welcomes contributions that employ traditional clinical, metabolic and epidemiologic methods, but is also interested in molecular and cell biology applied to human and animal nutrition.

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  1. Research

    Phenolic compounds apigenin, hesperidin and kaempferol reduce in vitro lipid accumulation in human adipocytes

    Adipocytes derived from human mesenchymal stem cells (MSCs) are widely used to investigate adipogenesis. Taking into account both the novelty of these MSCs and the scarcity of studies focused on the effects of...

    Saioa Gómez-Zorita, Arrate Lasa, Naiara Abendaño, Alfredo Fernández-Quintela, Andrea Mosqueda-Solís, Maria Pilar Garcia-Sobreviela, Jose M. Arbonés-Mainar and Maria P. Portillo

    Journal of Translational Medicine 2017 15:237

    Published on: 21 November 2017

  2. Research

    Effect of Infla-Kine supplementation on the gene expression of inflammatory markers in peripheral mononuclear cells and on C-reactive protein in blood

    Chronic inflammation is a predisposing factor to numerous degenerative diseases including cancer, heart failure and Alzheimer’s disease. Infla-Kine is a natural supplement comprised of a proprietary blend of Lact...

    Nina A. Mikirova, Santosh Kesari, Thomas E. Ichim and Neil H. Riordan

    Journal of Translational Medicine 2017 15:213

    Published on: 20 October 2017

  3. Research

    Altered Semmes–Weinstein monofilament test results are associated with oxidative stress markers in type 2 diabetic subjects

    Different lines of evidence suggest that oxidative stress (OS) is implicated in the pathogenesis of diabetic neuropathy. The Semmes–Weinstein monofilament (SWM) test is an efficient tool for evaluating diabeti...

    Sergio Martinez-Hervás, Mercedes Molina Mendez, José Folgado, Carmen Tormos, Pilar Ascaso, Marta Peiró, Jose T. Real and Juan F. Ascaso

    Journal of Translational Medicine 2017 15:187

    Published on: 6 September 2017

  4. Research

    Can psychobiotics intake modulate psychological profile and body composition of women affected by normal weight obese syndrome and obesity? A double blind randomized clinical trial

    Evidence of probiotics effects on gut function, brain activity and emotional behaviour were provided. Probiotics can have dramatic effects on behaviour through the microbiome–gut–brain axis, through vagus nerv...

    Antonino De Lorenzo, Micaela Costacurta, Giuseppe Merra, Paola Gualtieri, Giorgia Cioccoloni, Massimiliano Marchetti, Dimitrios Varvaras, Raffaella Docimo and Laura Di Renzo

    Journal of Translational Medicine 2017 15:135

    Published on: 10 June 2017

  5. Research

    Betaine promotes cell differentiation of human osteoblasts in primary culture

    Betaine (BET), a component of many foods, is an essential osmolyte and a source of methyl groups; it also shows an antioxidant activity. Moreover, BET stimulates muscle differentiation via insulin like growth ...

    Isabella Villa, Pamela Senesi, Anna Montesano, Anita Ferraretto, Fernanda Vacante, Alice Spinello, Michela Bottani, Simona Bolamperti, Alessandro Rubinacci, Livio Luzi and Ileana Terruzzi

    Journal of Translational Medicine 2017 15:132

    Published on: 7 June 2017

  6. Research article

    Standardization of platelet releasate products for clinical applications in cell therapy: a mathematical approach

    Standardized animal-free components are required for manufacturing cell-based medicinal products. Human platelet concentrates are sources of growth factors for cell expansion but such products are characterize...

    Francesco Agostini, Jerry Polesel, Monica Battiston, Elisabetta Lombardi, Stefania Zanolin, Alessandro Da Ponte, Giuseppe Astori, Cristina Durante and Mario Mazzucato

    Journal of Translational Medicine 2017 15:107

    Published on: 19 May 2017

  7. Research

    Preliminary results demonstrating the impact of Mediterranean diet on bone health

    Nutrition is an environmental factor affecting bone health. Nutrition is considered essential to achieve and maintain optimal bone mass. Mediterranean diet (MD) has shown to prevent bone disease. Aim of this s...

    Maria Cristina Savanelli, Luigi Barrea, Paolo Emidio Macchia, Silvia Savastano, Andrea Falco, Andrea Renzullo, Elisabetta Scarano, Immacolata Cristina Nettore, Annamaria Colao and Carolina Di Somma

    Journal of Translational Medicine 2017 15:81

    Published on: 24 April 2017

  8. Review

    Influence of diet on the gut microbiome and implications for human health

    Recent studies have suggested that the intestinal microbiome plays an important role in modulating risk of several chronic diseases, including inflammatory bowel disease, obesity, type 2 diabetes, cardiovascul...

    Rasnik K. Singh, Hsin-Wen Chang, Di Yan, Kristina M. Lee, Derya Ucmak, Kirsten Wong, Michael Abrouk, Benjamin Farahnik, Mio Nakamura, Tian Hao Zhu, Tina Bhutani and Wilson Liao

    Journal of Translational Medicine 2017 15:73

    Published on: 8 April 2017

  9. Research

    Hyperbranched polyglycerol is superior to glucose for long-term preservation of peritoneal membrane in a rat model of chronic peritoneal dialysis

    Replacing glucose with a better biocompatible osmotic agent in peritoneal dialysis (PD) solutions is needed in PD clinic. We previously demonstrated the potential of hyperbranched polyglycerol (HPG) as a repla...

    Caigan Du, Asher A. Mendelson, Qiunong Guan, Ghida Dairi, Irina Chafeeva, Gerald da Roza and Jayachandran N. Kizhakkedathu

    Journal of Translational Medicine 2016 14:338

    Published on: 13 December 2016

  10. Review

    Microbiota and neurologic diseases: potential effects of probiotics

    The microbiota colonizing the gastrointestinal tract have been associated with both gastrointestinal and extra-gastrointestinal diseases. In recent years, considerable interest has been devoted to their role i...

    Giulia Umbrello and Susanna Esposito

    Journal of Translational Medicine 2016 14:298

    Published on: 19 October 2016

  11. Research

    Effects of eight weeks of time-restricted feeding (16/8) on basal metabolism, maximal strength, body composition, inflammation, and cardiovascular risk factors in resistance-trained males

    Intermittent fasting (IF) is an increasingly popular dietary approach used for weight loss and overall health. While there is an increasing body of evidence demonstrating beneficial effects of IF on blood lipi...

    Tatiana Moro, Grant Tinsley, Antonino Bianco, Giuseppe Marcolin, Quirico Francesco Pacelli, Giuseppe Battaglia, Antonio Palma, Paulo Gentil, Marco Neri and Antonio Paoli

    Journal of Translational Medicine 2016 14:290

    Published on: 13 October 2016

  12. Research

    The fibrolytic potentials of vitamin D and thymoquinone remedial therapies: insights from liver fibrosis established by CCl4 in rats

    Vitamin D (VitD) and thymoquinone (TQ) are nutraceutical agents with well-known immunomodulatory and hepatoprotective properties. This study measured whether VitD and TQ, individually or combined, could have d...

    Abdelghany Hassan Abdelghany, Mohammad A. BaSalamah, Shakir Idris, Jawwad Ahmad and Bassem Refaat

    Journal of Translational Medicine 2016 14:281

    Published on: 29 September 2016

  13. Research

    Moniliformediquinone as a potential therapeutic agent, inactivation of hepatic stellate cell and inhibition of liver fibrosis in vivo

    Moniliformediquinone (MFD), a phenanthradiquinone in Dendrobium moniliforme, was synthesized in our laboratory. Beyond its in vitro inhibitory effects on cancer cells, other biological activity of MFD is unknown....

    Tsui-Hwa Tseng, Wea-Lung Lin, Zi-Hui Chen, Yean-Jang Lee, Ming-Shiun Shie, Kam-Fai Lee, Chien-Heng Shen and Hsing-Chun Kuo

    Journal of Translational Medicine 2016 14:263

    Published on: 9 September 2016

  14. Research

    Triglyceride glucose-waist circumference, a novel and effective predictor of diabetes in first-degree relatives of type 2 diabetes patients: cross-sectional and prospective cohort study

    Body mass index (BMI), waist circumference (WC), visceral adiposity index (VAI), triglyceride glucose index (TyG), TyG-BMI, and TyG-WC have been reported as markers of insulin resistance or type 2 diabetes mel...

    Shuang Zheng, Sheng Shi, Xingxing Ren, Tingting Han, Yangxue Li, Yawen Chen, Wei Liu, Peter C. Hou and Yaomin Hu

    Journal of Translational Medicine 2016 14:260

    Published on: 7 September 2016

  15. Protocol

    Modulation of endogenous antioxidant defense and the progression of kidney disease in multi-heritage groups of patients with type 2 diabetes: PRospective EValuation of Early Nephropathy and its Treatment (PREVENT)

    Diabetes is the western world’s leading cause of end-stage renal disease. Glucose-dependent, oxidative stress is linked to the development of renal inflammation and sclerosis, which, in animal models of diabet...

    Kenneth A. Earle, Karima Zitouni, John Pepe, Maria Karaflou and James Godbold Jr

    Journal of Translational Medicine 2016 14:234

    Published on: 4 August 2016

  16. Research

    The GLP-1 receptor agonists exenatide and liraglutide activate Glucose transport by an AMPK-dependent mechanism

    Potentiation of glucose-induced insulin secretion is the main mechanism of exenatide (EXE) antidiabetic action, however, increased glucose utilization by peripheral tissues has been also reported. We here stud...

    Francesco Andreozzi, Gregory Alexander Raciti, Cecilia Nigro, Gaia Chiara Mannino, Teresa Procopio, Alberto M. Davalli, Francesco Beguinot, Giorgio Sesti, Claudia Miele and Franco Folli

    Journal of Translational Medicine 2016 14:229

    Published on: 30 July 2016

  17. Research

    Interaction between polyphenols intake and PON1 gene variants on markers of cardiovascular disease: a nutrigenetic observational study

    Paraoxonase 1 (PON1) gene polymorphisms and polyphenols intake have been reported independently associated to lipid profile and susceptibility to atherosclerosis and cardiovascular disease. However, the intera...

    Federica Rizzi, Costanza Conti, Elena Dogliotti, Annalisa Terranegra, Erika Salvi, Daniele Braga, Flavia Ricca, Sara Lupoli, Alessandra Mingione, Francesca Pivari, Caterina Brasacchio, Matteo Barcella, Martina Chittani, Francesca D’Avila, Maurizio Turiel, Monica Lazzaroni…

    Journal of Translational Medicine 2016 14:186

    Published on: 23 June 2016

  18. Research

    Bioelectrical phase angle and psoriasis: a novel association with psoriasis severity, quality of life and metabolic syndrome

    Obesity, metabolic syndrome (MetS), and psoriasis, largely driven by environmental factors, show multiple bidirectional associations, with important metabolic implications in psoriatic patients. Besides body m...

    Luigi Barrea, Paolo Emidio Macchia, Carolina Di Somma, Maddalena Napolitano, Anna Balato, Andrea Falco, Maria Cristina Savanelli, Nicola Balato, Annamaria Colao and Silvia Savastano

    Journal of Translational Medicine 2016 14:130

    Published on: 10 May 2016

  19. Research

    Hericium erinaceus mycelium and its isolated erinacine A protection from MPTP-induced neurotoxicity through the ER stress, triggering an apoptosis cascade

    Hericium erinaceus is an edible mushroom; its various pharmacological effects which have been investigated. This study aimed to demonstrate whether efficacy of oral administration of H...

    Hsing-Chun Kuo, Chien-Chang Lu, Chien-Heng Shen, Shui-Yi Tung, Meng Chiao Hsieh, Ko-Chao Lee, Li-Ya Lee, Chin-Chu Chen, Chih-Chuan Teng, Wen-Shih Huang, Te-Chuan Chen and Kam-Fai Lee

    Journal of Translational Medicine 2016 14:78

    Published on: 18 March 2016

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