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Nutrition & Metabolism

Section edited by Laura Soldati

This section aims to provide a platform for the interaction and mutual validation between basic and applied research in the field of nutrition. In the area of Translational Medicine, we believe that the field ought to be taken into greater account in order to generate advanced applications for diagnosis and therapy and, at the same time, to develop new instruments of investigation.

Studies on all aspects of nutrition and metabolism with applications in medicine and biotechnology will be considered for publication. The section not only welcomes contributions that employ traditional clinical, metabolic and epidemiologic methods, but is also interested in molecular and cell biology applied to human and animal nutrition.

Featured articles

Hericium erinaceus mycelium and its isolated erinacine A protection from MPTP-induced neurotoxicity through the ER stress, triggering an apoptosis cascade
Hsing-Chun Kuo, et al

Obesity and colorectal cancer: molecular features of adipose tissue
Javier Martinez-Useros and Jesus Garcia-Foncillas



Role of a polyphenol-enriched preparation on chemoprevention of mammary carcinoma through cancer stem cells and inflammatory pathways modulation
Tri Vuong, et al

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  1. The morbidity of gestational diabetes mellitus (GDM) is increasing and is associated with adverse perinatal outcomes and long-term maternal and infant health. The exact mechanism underlying changes in plasma f...

    Authors: Haoyi Du, Danyang Li, Laura Monjowa Molive and Na Wu
    Citation: Journal of Translational Medicine 2024 22:180
  2. Proximal tubular cells (PTCs) play a critical role in the progression of diabetic kidney disease (DKD). As one of important progenitor markers, CD133 was reported to indicate the regeneration of dedifferentiat...

    Authors: Yuhan Zhang, Lusi Xu, Congcong Guo, Xianzhi Li, Yutian Tian, Lin Liao and Jianjun Dong
    Citation: Journal of Translational Medicine 2024 22:159
  3. Hidradenitis suppurativa (HS), an inflammatory-based dermatological condition often associated with obesity, poses significant challenges in management. The very low-calorie ketogenic diet (VLCKD) has shown ef...

    Authors: Ludovica Verde, Sara Cacciapuoti, Giuseppina Caiazzo, Matteo Megna, Fabrizio Martora, Annarita Cavaliere, Maria Mattera, Maria Maisto, Gian Carlo Tenore, Annamaria Colao, Silvia Savastano, Giovanna Muscogiuri and Luigi Barrea
    Citation: Journal of Translational Medicine 2024 22:149
  4. Excessive energy intake in modern society has led to an epidemic surge in metabolic diseases, such as obesity and type 2 diabetes, posing profound threats to women’s reproductive health. However, the precise i...

    Authors: Congcong Liu, Yunde Dou, Mengge Zhang, Shan Han, Shourui Hu, Yuxuan Li, Zhiheng Yu, Yue Liu, Xiaofan Liang, Zi-Jiang Chen, Han Zhao and Yuqing Zhang
    Citation: Journal of Translational Medicine 2024 22:145
  5. Bone is a metabolically active tissue containing different cell types acting as endocrine targets and effectors. Further, bone is a dynamic depot for calcium, phosphorous and other essential minerals. The tiss...

    Authors: Amir Mohammad Malvandi, Esra Halilaj, Martina Faraldi, Laura Mangiavini, Simone Cristoni, Valerio Leoni and Giovanni Lombardi
    Citation: Journal of Translational Medicine 2024 22:143
  6. Overweight is known to be an important risk factor for colorectal cancer (CRC), and the differences in intestinal flora among CRC patients with different BMI status have not been clearly defined. The purpose o...

    Authors: Yongqi Huang, Xiaoliang Huang, Zhen Wang, Fuhai He, Zigui Huang, Chuanbin Chen, Binzhe Tang, Mingjian Qin, Yongzhi Wu, Chenyan Long, Weizhong Tang, Xianwei Mo and Jungang Liu
    Citation: Journal of Translational Medicine 2024 22:142
  7. Overweight and obesity are established risk factors for various types of cancers including colorectal cancer (CRC). However the underlying molecular mechanisms remain unclear. An in-depth understanding of the ...

    Authors: Guozhong Xiao, Yihui Zheng, Huaxian Chen, Minyi Luo, Chaoxin Yang, Donglin Ren, Pengfei Qin, Heng Zhang and Hongcheng Lin
    Citation: Journal of Translational Medicine 2024 22:134
  8. Vitamin D (VD) is implicated in various health conditions, including colorectal cancer (CRC). To investigate potential relationships between pre-chemotherapy VD levels and the time-to-outcome in metastatic CRC...

    Authors: Alessandro Ottaiano, Maria Lucia Iacovino, Mariachiara Santorsola, Sergio Facchini, Domenico Iervolino, Francesco Perri, Guglielmo Nasti, Vincenzo Quagliariello, Nicola Maurea, Andrea Ronchi, Bianca Arianna Facchini, Alessia Bignucolo and Massimiliano Berretta
    Citation: Journal of Translational Medicine 2024 22:119
  9. Converging data have suggested that monocytic inflammation and C-reactive protein (CRP) are biologically intertwined processes and are involved in diabetogenesis. This study aimed to investigate the associatio...

    Authors: Dan Wu, Genyuan Chen, Yulong Lan, Shuohua Chen, Xiong Ding, Chiju Wei, Lois Balmer, Wei Wang, Shouling Wu and Wencan Xu
    Citation: Journal of Translational Medicine 2024 22:110
  10. Atherosclerosis is a chronic, progressive, inflammatory disease that occurs in the arterial wall. Despite recent advancements in treatment aimed at improving efficacy and prolonging survival, atherosclerosis r...

    Authors: Huiling Lin, Ming Zhang, Mi Hu, Yangkai Zhang, WeiWei Jiang, Wanying Tang, Yuxin Ouyang, Liping Jiang, Yali Mi, Zhi Chen, Pingping He, Guojun Zhao and Xinping Ouyang
    Citation: Journal of Translational Medicine 2024 22:97
  11. Obesity, a condition associated with the development of widespread cardiovascular disease, metabolic disorders, and other health complications, has emerged as a significant global health issue. Oleanolic acid ...

    Authors: Tianfeng Liu, Jiliang Wang, Ying Tong, Lele Wu, Ying Xie, Ping He, Shujue Lin and Xuguang Hu
    Citation: Journal of Translational Medicine 2024 22:86
  12. Mediterranean Diet (MD) has many health benefits, particularly in reducing cardiovascular risk (CVR). However, it is still little known if there are any sex differences in following this nutritional pattern an...

    Authors: Luigi Barrea, Ludovica Verde, Rosario Suárez, Evelyn Frias-Toral, Celina Andrade Vásquez, Annamaria Colao, Silvia Savastano and Giovanna Muscogiuri
    Citation: Journal of Translational Medicine 2024 22:44
  13. Dietary sulfur amino acid restriction (SAAR) improves metabolic health in animals. In this study, we investigated the effect of dietary SAAR on body weight, body composition, resting metabolic rate, gene expre...

    Authors: Thomas Olsen, Emma Stolt, Bente Øvrebø, Amany Elshorbagy, Elena C. Tore, Sindre Lee-Ødegård, Hannibal Troensegaard, Hanna Johannessen, Beate Doeland, Anna A. D. Vo, Anja F. Dahl, Karianne Svendsen, Magne Thoresen, Helga Refsum, Russell Rising, Kristýna Barvíková…
    Citation: Journal of Translational Medicine 2024 22:40
  14. Patients with type 2 diabetes mellitus (T2DM) are at higher risk of developing atherosclerosis. Previous studies have analyzed the factors associated with diabetic macrovascular disease, although whether these...

    Authors: Jin Chen, Wenwen Li, Jingzhu Cao, Yuhan Lu, Chaoqun Wang and Jin Lu
    Citation: Journal of Translational Medicine 2024 22:18
  15. Pain is a worldwide problem requiring an effective, affordable, non-addictive therapy. Using the edible plant broccoli, a growth protocol was developed to induce a concentrated combinatorial of potential anti-...

    Authors: Aleksandra A. Gurgul, Yahya Najjar, Ana Chee, Howard An, Chun-Tao Che, Thomas J. Park and Katherine M. Warpeha
    Citation: Journal of Translational Medicine 2023 21:922
  16. Previous studies have demonstrated that high-density lipoprotein cholesterol (HDL-C) plays an anti-atherosclerosis role through reverse cholesterol transport. Several studies have validated the efficacy and sa...

    Authors: Yilin Chen, Fengwei Zhang, Jijia Sun and Lei Zhang
    Citation: Journal of Translational Medicine 2023 21:920
  17. Bioelectrical impedance analysis (BIA) is a rapid and user-friendly technique for assessing body composition in sports. Currently, no sport-specific predictive equations are available, and the utilization of g...

    Authors: Francesco Campa, Tindaro Bongiovanni, Alessio Rossi, Giuseppe Cerullo, Andrea Casolo, Giulia Martera, Athos Trecroci, Tatiana Moro and Antonio Paoli
    Citation: Journal of Translational Medicine 2023 21:912
  18. Obesity, characterized by visceral adipose tissue (VAT) expansion, is closely associated with metabolic dysfunction-associated steatotic liver disease (MASLD) and metabolic dysfunction-associated steatohepatit...

    Authors: Noel Salvoza, Pablo Giraudi, Silvia Gazzin, Deborah Bonazza, Silvia Palmisano, Nicolò de Manzini, Fabrizio Zanconati, Alan Raseni, Francesca Sirianni, Claudio Tiribelli and Natalia Rosso
    Citation: Journal of Translational Medicine 2023 21:906
  19. The consumption of various herbal infusions was and is common in the traditional Mediterranean diet, and apparently are used in many other regions of the world outside of the Mediterranean region. The present ...

    Authors: Ekaterina-Michaela Tomou, Eleni Peppa and Antonia Trichopoulou
    Citation: Journal of Translational Medicine 2023 21:899
  20. The current body of evidence on the association between the ratio of triglycerides to high-density lipoprotein cholesterol (TG/HDL-c) and the reversal of prediabetes to normoglycemia remains limited. The aim o...

    Authors: Zhiqiang Huang, Yong Han, Haofei Hu, Changchun Cao, Dehong Liu and Zhibin Wang
    Citation: Journal of Translational Medicine 2023 21:868
  21. Psoriasis is a chronic inflammatory skin disease with metabolic abnormalities serving as important contributors for pathogenesis and progression. Polyunsaturated fatty acids (PUFAs) have been found to be assoc...

    Authors: Xin Wang, Rui Ma, Rongcan Shi, Hui Qin, Wenjuan Chen, Zengyang Yu, Yangfeng Ding, Chen Peng and Yuling Shi
    Citation: Journal of Translational Medicine 2023 21:834
  22. Med-Index is a one-health front-of-pack (FOP) label, based on Mediterranean diet (MedDiet) principles, developed to summarize information about the nutritional properties and related-health benefits of any foo...

    Authors: Roberta Zupo, Fabio Castellana, Prisco Piscitelli, Pasquale Crupi, Addolorata Desantis, Enrico Greco, Franca Paola Severino, Manuela Pulimeno, Andrea Guazzini, Tassos C. Kyriakides, Vasilis Vasiliou, Antonia Trichopoulou, Laura Soldati, Carlo La Vecchia, Giovanni De Gaetano, Maria Benedetta Donati…
    Citation: Journal of Translational Medicine 2023 21:755
  23. The available evidence indicates that the severity of metabolic syndrome tends to worsen progressively over time. We assessed the trajectory of age and sex-specific continuous MetS severity score (cMetS-S) and...

    Authors: Atieh Amouzegar, Mohammadjavad Honarvar, Safdar Masoumi, Davood Khalili, Fereidoun Azizi and Ladan Mehran
    Citation: Journal of Translational Medicine 2023 21:750
  24. This study aimed to develop a simplified diagnostic tool for assessing sarcopenia and myosteatosis in gastrointestinal cancer patients, focusing on the creatinine to cystatin C ratio (CCR) as an evaluation mar...

    Authors: Hao Liu, Junjie Wang, Shanjun Tan, Zhige Zhang, Mingyue Yan, Jun Han, Xiangyu Sui, Fan Yang and Guohao Wu
    Citation: Journal of Translational Medicine 2023 21:744
  25. Changes in the gut microbiota composition is a hallmark of chronic kidney disease (CKD), and interventions targeting the gut microbiota present a potent approach for CKD treatment. This study aimed to evaluate...

    Authors: Hao-Jie Zhong, Xinqiang Xie, Wen-Jia Chen, Yu-Pei Zhuang, Xuan Hu, Ying-Li Cai, Hong-Lie Zeng, Chuanxing Xiao, Ying Li, Yu Ding, Liang Xue, Moutong Chen, Jumei Zhang, Qingping Wu and Xing-Xiang He
    Citation: Journal of Translational Medicine 2023 21:740
  26. Whether serum vitamin D mediate vascular diseases in prediabetic populations remains unclear. This study aimed to determine the associations between circulating 25-hydroxyvitamin D [25(OH)D] levels and vitamin...

    Authors: Pingting Zhong, Zhuoting Zhu, Yunlong Wang, Wenyong Huang, Mingguang He and Wei Wang
    Citation: Journal of Translational Medicine 2023 21:724
  27. Early-stage detection of chronic kidney diseases (CKD) is important to treatment that may slow and occasionally halt CKD progression. CKD of diverse etiologies share similar histologic patterns of glomeruloscl...

    Authors: Colleen S. Curran and Jeffrey B. Kopp
    Citation: Journal of Translational Medicine 2023 21:706
  28. The increasing prevalence of metabolic and cardiovascular diseases poses a significant challenge to global healthcare systems. Regular physical activity (PA) is recognized for its positive impact on cardiovasc...

    Authors: Chang Sheng, Weihua Huang, Wei Wang, Guoqiang Lin, Mingmei Liao and Pu Yang
    Citation: Journal of Translational Medicine 2023 21:705
  29. Non-alcoholic fatty liver disease (NAFLD) is a common liver disease increasing cardiovascular disease (CVD) morbidity and mortality. Autoantibodies against apolipoprotein A-1 (AAA-1) are a possible novel CVD r...

    Authors: Sabrina Pagano, Stephan J. L. Bakker, Catherine Juillard, Stefania Vossio, Dimitri Moreau, Karim J. Brandt, François Mach, Robin P. F. Dullaart and Nicolas Vuilleumier
    Citation: Journal of Translational Medicine 2023 21:694
  30. Migraine is the second world’s cause of disability. Among non-pharmacological treatments, nutritional intervention, particularly ketogenic diet, represents one of the most promising approaches.

    Authors: Massimiliano Caprio, Eleonora Moriconi, Elisabetta Camajani, Alessandra Feraco, Vincenzo Marzolla, Laura Vitiello, Stefania Proietti, Andrea Armani, Stefania Gorini, Caterina Mammi, Gabriella Egeo, Cinzia Aurilia, Giulia Fiorentini, Carlo Tomino and Piero Barbanti
    Citation: Journal of Translational Medicine 2023 21:692
  31. Metabolic syndrome (MetS), a worldwide public health problem, affects human health and quality of life in a dramatic manner. A growing evidence base suggests that MetS is strongly associated with levels of sys...

    Authors: Yang Zhao, Wenyu Shao, Qihan Zhu, Rui Zhang, Tao Sun, Bijia Wang and Xiaofei Hu
    Citation: Journal of Translational Medicine 2023 21:691
  32. There is little prospective evidence exists about whether adherence to a diabetes risk reduction diet (DRRD) is related to a significant reduction in renal cancer risk. We sought to clarify whether adherence t...

    Authors: Ling Xiang, Yi Xiao, Zhiquan Xu, Haoyun Luo, Xiaorui Ren, Qi Wei, Zhiyong Zhu, Yahui Jiang, Yunhao Tang, Hongmei He, Zhihang Zhou, Haitao Gu, Yaxu Wang and Linglong Peng
    Citation: Journal of Translational Medicine 2023 21:684
  33. Previous studies have assessed the association between antidiabetic drugs and stroke risk, but the results are inconsistent. Mendelian randomization (MR) was used to assess effects of antidiabetic drugs on str...

    Authors: Yahui Zhu, Mao Li, Hongfen Wang, Fei Yang, Xinyuan Pang, Rongrong Du, Jinghong Zhang and Xusheng Huang
    Citation: Journal of Translational Medicine 2023 21:681
  34. This study aims to comprehensively investigate the phenotypic and genetic relationships between four common lipids (high-density lipoprotein cholesterol, HDL-C; low-density lipoprotein cholesterol, LDL-C; tota...

    Authors: Yutong Wang, Li Zhang, Wenqiang Zhang, Mingshuang Tang, Huijie Cui, Xueyao Wu, Xunying Zhao, Lin Chen, Peijing Yan, Chao Yang, Chenghan Xiao, Yanqiu Zou, Yunjie Liu, Ling Zhang, Chunxia Yang, Yuqin Yao…
    Citation: Journal of Translational Medicine 2023 21:671
  35. Plant-based dietary patterns may affect colorectal cancer (CRC) related outcomes, while risks differ in the quality of plant foods. We aimed to examine the association of plant-based diet quality with risks of...

    Authors: Fubin Liu, Yanling Lv, Yu Peng, Yating Qiao, Peng Wang, Changyu Si, Xixuan Wang, Jianxiao Gong, Huijun Zhou, Ming Zhang, Liangkai Chen and Fangfang Song
    Citation: Journal of Translational Medicine 2023 21:669
  36. Osteoporosis is a systemic bone disease characterized by low bone mass, microarchitectural deterioration, increased bone fragility, and fracture susceptibility. It commonly occurs in older people, especially p...

    Authors: Dong Wu, Lei Li, Zhun Wen and Guangbin Wang
    Citation: Journal of Translational Medicine 2023 21:668
  37. The prevention and treatment of osteoarthritis (OA) pose a major challenge in its research. The synovium is a critical tissue in the systematic treatment of OA. The present study aimed to investigate potential...

    Authors: Zhuangzhuang Jin, He Zhang, Lunhao Bai, Lingyu Yue, Weiming Zhang, Jiajian Liang, Bohan Chang, Yue Yang, Zhehan Hu, Liang Chen and Chuanji Guo
    Citation: Journal of Translational Medicine 2023 21:661
  38. Vitamin D deficiency is common among the population, but its relationship with mortality of postmenopausal females is unclear. The aim of this study is to explore the association between serum 25-Hydroxyvitami...

    Authors: Jia-Wei Shi, Jiang-Nan Wu, Xiao-Yong Zhu, Wen-Hui Zhou, Jin-Ying Yang and Ming-Qing Li
    Citation: Journal of Translational Medicine 2023 21:629
  39. Owing to the heterogeneity of Alzheimer's disease (AD), its pathogenic mechanisms are yet to be fully elucidated. Evidence suggests an important role of metabolism in the pathophysiology of AD. Herein, we iden...

    Authors: Piaopiao Lian, Xing Cai, Cailin Wang, Ke Liu, Xiaoman Yang, Yi Wu, Zhaoyuan Zhang, Zhuoran Ma, Xuebing Cao and Yan Xu
    Citation: Journal of Translational Medicine 2023 21:628
  40. Triglyceride glucose index (TyG index) has been recommended as an alternative indicator of insulin resistance. However, the association between TyG and regression from prediabetes to normoglycemia remains to b...

    Authors: Xiaojie Chen, Danfeng Liu, Weiting He, Haofei Hu and Wenjian Wang
    Citation: Journal of Translational Medicine 2023 21:624
  41. Chronic obstructive pulmonary disease (COPD) patients often exhibit gastrointestinal symptoms, A potential association between COPD and Colorectal Cancer (CRC) has been indicated, warranting further examination.

    Authors: Youtao Zhou, Zikai Lin, Shuojia Xie, Yuan Gao, Haobin Zhou, Fengzhen Chen, Yuewu Fu, Cuiyan Yang and Chuanfeng Ke
    Citation: Journal of Translational Medicine 2023 21:587
  42. Insulin resistance (IR) is considered the main driver of obesity related metabolic complications, and is related to oxidative stress and inflammation, which in turn promote each other. There is currently no sp...

    Authors: Álvaro González-Domínguez, Thalía Belmonte, Jesús Domínguez-Riscart, Pablo Ruiz-Ocaña, Inés Muela-Zarzuela, Ana Saez-Benito, Raúl Montañez-Martínez, Rosa M. Mateos and Alfonso M. Lechuga-Sancho
    Citation: Journal of Translational Medicine 2023 21:559
  43. Limited research has been conducted on the potential relationship between the dietary inflammation index (DII) and mortality, particularly in individuals with Helicobacter pylori (H. pylori) infection. This st...

    Authors: Yu-Jun Xiong, Lei-Lei Du, Yun-Lian Diao, Jun Wen, Xiang-Bin Meng, Jun Gao, Chun-Li Shao, Wen-Yao Wang, Xing-yun Zhu and Yi-Da Tang
    Citation: Journal of Translational Medicine 2023 21:538
  44. Studies have examined the effect of weight change on osteoporosis, but the results were controversial. Among them, few had looked at weight change over the life span. This study aimed to fill this gap and inve...

    Authors: Jiacheng Wang, Yi Zheng, Yawen Wang, Chengjun Zhang, Yanfeng Jiang, Chen Suo, Mei Cui, Tiejun Zhang, Xingdong Chen and Kelin Xu
    Citation: Journal of Translational Medicine 2023 21:536
  45. No evidence has been found of a relationship between remnant cholesterol (RC) and the likelihood of gestational diabetes mellitus (GDM) in pregnant women. The aim of our study was to investigate the link betwe...

    Authors: Yajing Gao, Yanhua Hu and Lan Xiang
    Citation: Journal of Translational Medicine 2023 21:531
  46. This paper aimed to examine the effects of probiotics on eight factors in overweight or obese children by meta-analysis, namely, body mass index (BMI), total cholesterol (TC), triglyceride (TG), high-density l...

    Authors: Ya Li, Tonghua Liu, Lingling Qin and Lili Wu
    Citation: Journal of Translational Medicine 2023 21:525
  47. Abdominal obesity has long been considered as a crucial risk factor of stroke. Chinese visceral adiposity index (CVAI), a novel surrogate indicator of abdominal obesity, has been confirmed as a better predicto...

    Authors: Zenglei Zhang, Lin Zhao, Yiting Lu, Xu Meng and Xianliang Zhou
    Citation: Journal of Translational Medicine 2023 21:518

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