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Nutrition & metabolism

Section edited by Laura Soldati

This section aims to provide a platform for the interaction and mutual validation between basic and applied research in the field of nutrition. In the area of Translational Medicine, we believe that the field ought to be taken into greater account in order to generate advanced applications for diagnosis and therapy and, at the same time, to develop new instruments of investigation.

Studies on all aspects of nutrition and metabolism with applications in medicine and biotechnology will be considered for publication. The section not only welcomes contributions that employ traditional clinical, metabolic and epidemiologic methods, but is also interested in molecular and cell biology applied to human and animal nutrition.

Featured articles

Hericium erinaceus mycelium and its isolated erinacine A protection from MPTP-induced neurotoxicity through the ER stress, triggering an apoptosis cascade
Hsing-Chun Kuo, et al

Obesity and colorectal cancer: molecular features of adipose tissue
Javier Martinez-Useros and Jesus Garcia-Foncillas



Role of a polyphenol-enriched preparation on chemoprevention of mammary carcinoma through cancer stem cells and inflammatory pathways modulation
Tri Vuong, et al

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  1. To observe the effect of rapid weight loss (RWL) methods over 3 days on muscle damage in judokas.

    Authors: Roberto Roklicer, Nemanja Lakicevic, Valdemar Stajer, Tatjana Trivic, Antonino Bianco, Diba Mani, Zoran Milosevic, Nebojsa Maksimovic, Antonio Paoli and Patrik Drid

    Citation: Journal of Translational Medicine 2020 18:142

    Content type: Research

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  2. It is unclear the role of longitudinal trajectory of serum uric acid (SUA) on the development of non-alcoholic fatty liver disease (NAFLD). We aimed to determine whether longitudinal SUA trajectories are assoc...

    Authors: Zhimin Ma, Chaonan Xu, Xiaoping Kang, Shan Zhang, Haibin Li, Lixin Tao, Deqiang Zheng, Xiuhua Guo and Xinghua Yang

    Citation: Journal of Translational Medicine 2020 18:133

    Content type: Research

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  3. Kidney stone disease (KSD) is more common in individuals with hypertension (HTN) than in individuals with normotension (NTN). Urinary dysbiosis is associated with urinary tract disease and systemic diseases. H...

    Authors: Fengping Liu, Nan Zhang, Peng Jiang, Qixiao Zhai, Chen Li, Deshui Yu, Yan Wu, Yuwei Zhang, Longxian Lv, Xinyu Xu and Ninghan Feng

    Citation: Journal of Translational Medicine 2020 18:130

    Content type: Research

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  4. The role of the human microbiome in human health and disease has been studied in various body sites. However, compared to the gut microbiome, where most of the research focus is, the salivary microbiome still ...

    Authors: Selvasankar Murugesan, Sara Fahad Al Ahmad, Parul Singh, Marwa Saadaoui, Manoj Kumar and Souhaila Al Khodor

    Citation: Journal of Translational Medicine 2020 18:127

    Content type: Research

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  5. Dietary restriction of methionine and cysteine is a well-described model that improves metabolic health in rodents. To investigate the translational potential in humans, we evaluated the effects of dietary met...

    Authors: Thomas Olsen, Bente Øvrebø, Nadia Haj-Yasein, Sindre Lee, Karianne Svendsen, Marit Hjorth, Nasser E. Bastani, Frode Norheim, Christian A. Drevon, Helga Refsum and Kathrine J. Vinknes

    Citation: Journal of Translational Medicine 2020 18:122

    Content type: Research

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  6. Human defensin-5 (HD-5) is a key antimicrobial peptide which plays an important role in host immune defense, while the short half-life greatly limits its clinical application. The purpose of this study was to ...

    Authors: Lishan Zeng, Jiasheng Tan, Meng Xue, Le Liu, Mingming Wang, Liping Liang, Jun Deng, Wei Chen and Ye Chen

    Citation: Journal of Translational Medicine 2020 18:107

    Content type: Research

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  7. Thiazide diuretics reduce the risk of recurrent kidney calculi in patients with kidney calculi or hypercalciuria. However, whether thiazide diuretics can definitely prevent recurrent kidney calculi remains unc...

    Authors: Dan-feng Li, Yu-lu Gao, Hong-chao Liu, Xiao-chen Huang, Rui-fang Zhu and Chang-tai Zhu

    Citation: Journal of Translational Medicine 2020 18:106

    Content type: Review

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  8. Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in women during reproductive age. It is characterised clinically by oligo-ovulation or anovulation, hyper-androgenism, and the presence of...

    Authors: Antonio Paoli, Laura Mancin, Maria Cristina Giacona, Antonino Bianco and Massimiliano Caprio

    Citation: Journal of Translational Medicine 2020 18:104

    Content type: Research

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  9. The present study compared the effects of training and detraining periods of high-intensity interval training (HIIT), moderate-intensity interval training (MIIT) and moderate-intensity continuous training (MIC...

    Authors: Victor Silveira Coswig, Matheus Barbalho, Rodolfo Raiol, Fabrício Boscolo Del Vecchio, Rodrigo Ramirez-Campillo and Paulo Gentil

    Citation: Journal of Translational Medicine 2020 18:88

    Content type: Research

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  10. Despite the efficacy of immune checkpoint inhibitors (ICIs) only the 20–30% of treated patients present long term benefits. The metabolic changes occurring in the gut microbiota metabolome are herein proposed ...

    Authors: Andrea Botticelli, Pamela Vernocchi, Federico Marini, Andrea Quagliariello, Bruna Cerbelli, Sofia Reddel, Federica Del Chierico, Francesca Di Pietro, Raffaele Giusti, Alberta Tomassini, Ottavia Giampaoli, Alfredo Miccheli, Ilaria Grazia Zizzari, Marianna Nuti, Lorenza Putignani and Paolo Marchetti

    Citation: Journal of Translational Medicine 2020 18:49

    Content type: Research

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  11. There are several effective therapies for osteoporosis but these agents might cause serious adverse events. Lycopene intake could prevent bone loss, however studies on its effects on bone are scarce. Our aim w...

    Authors: Cristina Russo, Yvelise Ferro, Samantha Maurotti, Maria Antonietta Salvati, Elisa Mazza, Roberta Pujia, Rosa Terracciano, Giuseppina Maggisano, Rosario Mare, Sandro Giannini, Stefano Romeo, Arturo Pujia and Tiziana Montalcini

    Citation: Journal of Translational Medicine 2020 18:43

    Content type: Research

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  12. Circadian rhythms play a fundamental role in the progression of cardiovascular events. Almost all cardiovascular diseases have a circadian misalignment usually characterized by changes in metabolites. This stu...

    Authors: Huanjun Wang, Xiaoming Wang, Dongmei Qi, Mengjia Sun, Qingqing Hou, Yunlun Li and Haiqiang Jiang

    Citation: Journal of Translational Medicine 2020 18:38

    Content type: Research

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  13. The manipulation of gut microbiota as a target has been suggested to reduce the risks for a number of diseases such as type 2 diabetes mellitus (T2DM). Conversely, T2DM is associated with complications such as...

    Authors: Mohammad Morshedi, Maryam Saghafi-Asl and Elaheh-Sadat Hosseinifard

    Citation: Journal of Translational Medicine 2020 18:18

    Content type: Research

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  14. Epidemiologic studies show that cocaine- and amphetamine-regulated transcript prepropeptide (CARTPT) gene polymorphism modifies diet-obesity relationships. However, the interaction between CARTPT gene polymorp...

    Authors: Mahsa Mahmoudi-Nezhad, Mahdieh Abbasalizad Farhangi and Houman Kahroba

    Citation: Journal of Translational Medicine 2020 18:16

    Content type: Research

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  15. The growth differentiation factor 11 (GDF11) was shown to reverse age-related hypertrophy on cardiomyocytes and considered as anti-aging rejuvenation factor. The role of GDF11 in regulating metabolic homeostas...

    Authors: Bingxin Lu, Jianing Zhong, Jianfei Pan, Xiaopeng Yuan, Mingzhi Ren, Liping Jiang, Yuqing Yang, Guisheng Zhang, Dexi Liu and Chunbo Zhang

    Citation: Journal of Translational Medicine 2019 17:422

    Content type: Research

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  16. Tacrolimus (FK506)-induced diabetes mellitus is one of the most important factors of post-transplant diabetes mellitus (PTDM). However, the detailed mechanisms underlying PTDM are still unclear. Farnesoid X re...

    Authors: Ling Li, Huijia Zhao, Binyao Chen, Zhipeng Fan, Ning Li, Jiang Yue and Qifa Ye

    Citation: Journal of Translational Medicine 2019 17:418

    Content type: Research

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  17. Currently, many clinical trials have shown that inulin-type fructans (ITF) supplementation is associated with glycemic control; nevertheless, the results are inconclusive. The aim of this meta-analysis of rand...

    Authors: Long Wang, Hong Yang, Hao Huang, Chao Zhang, Hong-Xia Zuo, Pan Xu, Yu-Ming Niu and Shi-Shi Wu

    Citation: Journal of Translational Medicine 2019 17:410

    Content type: Research

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  18. The “nonclassic” apparent mineralocorticoid excess (NC-AME) has been identified in approximately 7% of general population. This phenotype is characterized by low plasma renin activity (PRA), high serum cortiso...

    Authors: Alejandra Tapia-Castillo, Dominic Guanzon, Carlos Palma, Andrew Lai, Eric Barros, Fidel Allende, Andrea Vecchiola, Carlos E. Fardella, Carlos Salomón and Cristian A. Carvajal

    Citation: Journal of Translational Medicine 2019 17:392

    Content type: Research

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  19. Conflicting evidence exists on the relationship between body mass index (BMI) and serum uric acid (SUA). Therefore, we aimed to evaluate the SUA–BMI relationship in a large-scale epidemiological survey in coas...

    Authors: Hui Zhou, Zhen Liu, Zhong Chao, Yeqing Chao, Lidan Ma, Xiaoyu Cheng, Yangang Wang, Changgui Li and Ying Chen

    Citation: Journal of Translational Medicine 2019 17:389

    Content type: Research

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  20. Cystic fibrosis (CF) is one of the most frequent genetic diseases and the median survival of these patients has improved in the last few decades, therefore it becomes necessary to evaluate the long-term compli...

    Authors: Silvia Lai, Sandro Mazzaferro, Anna Paola Mitterhofer, Enea Bonci, Paolo Giangreco Marotta, Francesco Pelligra, Manuel Murciano, Camilla Celani, Patrizia Troiani, Giuseppe Cimino and Paolo Palange

    Citation: Journal of Translational Medicine 2019 17:388

    Content type: Research

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  21. Alcohol withdrawal syndrome (AWS) is routinely treated with B-vitamins. However, the relationship between thiamine status and outcome is rarely examined. The aim of the present study was to examine the relatio...

    Authors: Donogh Maguire, Dinesh Talwar, Alana Burns, Anthony Catchpole, Fiona Stefanowicz, Gordon Robson, David P. Ross, David Young, Alastair Ireland, Ewan Forrest, Peter Galloway, Michael Adamson, Eoghan Colgan, Hannah Bell, Lesley Orr, Joanna-Lee Kerr…

    Citation: Journal of Translational Medicine 2019 17:384

    Content type: Research

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  22. Breastfeeding is the ideal source of infant nutrition. Human milk consists not only of nutrients but also biologically active components. Among these latter compounds, exosomes contain proteins, lipids, mRNAs ...

    Authors: Shimon Reif, Yaffa Elbaum Shiff and Regina Golan-Gerstl

    Citation: Journal of Translational Medicine 2019 17:325

    Content type: Research

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  23. To investigate the association of serum levels of 25(OH)D and 1,25(OH)2D3 in healthy and non-healthy controls with Crohn’s disease (CD) and ulcerative colitis (UC).

    Authors: Xi-Xi Li, Yang Liu, Jie Luo, Zhen-Dong Huang, Chao Zhang and Yan Fu

    Citation: Journal of Translational Medicine 2019 17:323

    Content type: Research

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  24. This study was conducted to investigate whether the daily consumption of haem, non-haem, total iron and red meat can affect the occurrence of metabolic syndrome (MetS) and its components.

    Authors: Zohre Esfandiar, Firoozeh Hosseini-Esfahani, Parvin Mirmiran, Ali-Siamak Habibi-Moeini and Fereidoun Azizi

    Citation: Journal of Translational Medicine 2019 17:313

    Content type: Research

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  25. Adipose tissue remodeling plays a significant role in obesity-induced insulin resistance. Published studies reported that level of trigger receptor expressed on myeloid cells 2 (TREM2) in adipose tissue is up-...

    Authors: Can Liu, Pinhao Li, Hui Li, Sicong Wang, Lifeng Ding, Hanbin Wang, Hui Ye, Yue Jin, Jinchao Hou, Xiangming Fang and Qiang Shu

    Citation: Journal of Translational Medicine 2019 17:300

    Content type: Research

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  26. The effects of fasting on health in non-human models have been widely publicised for a long time and emerging evidence support the idea that these effects can be applicable to human practice.

    Authors: Iftikhar Alam, Rahmat Gul, Joni Chong, Crystal Tze Ying Tan, Hui Xian Chin, Glenn Wong, Radhouene Doggui and Anis Larbi

    Citation: Journal of Translational Medicine 2019 17:272

    Content type: Research

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  27. Obesity is a chronic and systemic inflammatory disorder and an important risk factor for the onset of several chronic syndromes. Adipose tissue (AT) plays a crucial role in the development of obesity, promotin...

    Authors: Federica Tomay, Alessandra Marinelli, Valerio Leoni, Claudio Caccia, Andrea Matros, Hans-Peter Mock, Chiara Tonelli and Katia Petroni

    Citation: Journal of Translational Medicine 2019 17:237

    Content type: Research

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  28. Diabetic nephropathy (DN) is associated with high risk of cardiovascular disease and mortality. Exosomal microRNAs (miRNAs) regulate gene expression in a variety of tissues and play important roles in the path...

    Authors: Hyoungnae Kim, Yun-Ui Bae, Jin Seok Jeon, Hyunjin Noh, Hyeong Kyu Park, Dong Won Byun, Dong Cheol Han, Seongho Ryu and Soon Hyo Kwon

    Citation: Journal of Translational Medicine 2019 17:236

    Content type: Research

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  29. Lifestyle intervention may have a critical effect on the association between genetics and obesity. This study aimed to investigate changes in FTO and IRX3 gene expression in obese and overweight male adolescents ...

    Authors: Saeid Doaei, Naser Kalantari, Pantea Izadi, Tuire Salonurmi, Alireza Mosavi Jarrahi, Shahram Rafieifar, Ghasem Azizi Tabesh, Ghazaleh Rahimzadeh, Maryam Gholamalizadeh and Mark O. Goodarzi

    Citation: Journal of Translational Medicine 2019 17:176

    Content type: Research

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  30. Obesity must be considered a real pathology. In the world wide, obesity represent one of the major public health issue associated with increased morbidity and mortality. Overweight or obesity, in fact, signifi...

    Authors: Antonino De Lorenzo, Santo Gratteri, Paola Gualtieri, Andrea Cammarano, Pierfrancesco Bertucci and Laura Di Renzo

    Citation: Journal of Translational Medicine 2019 17:169

    Content type: Review

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  31. Non-alcoholic fatty liver disease (NAFLD) is the most common liver disease in humans, and ranges from steatosis to non-alcoholic steatohepatitis (NASH), the latter with risk of progression to cirrhosis. The Gö...

    Authors: Camilla Schumacher-Petersen, Berit Østergaard Christoffersen, Rikke Kaae Kirk, Trine Pagh Ludvigsen, Nora Elisabeth Zois, Henrik Duelund Pedersen, Mogens Vyberg and Lisbeth Høier Olsen

    Citation: Journal of Translational Medicine 2019 17:110

    Content type: Research

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  32. Human growth is a complex mechanism that depends on genetic, environmental, nutritional and hormonal factors. The main hormone involved in growth at each stage of development is growth hormone (GH) and its med...

    Authors: Susanna Esposito, Alberto Leonardi, Lucia Lanciotti, Marta Cofini, Giulia Muzi and Laura Penta

    Citation: Journal of Translational Medicine 2019 17:87

    Content type: Review

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  33. Gastrointestinal microbiome has drawn an increasing amount of attention over the past decades. There is emerging evidence that the gut flora plays a major role in the pathogenesis of certain diseases. We aimed...

    Authors: Xiaoquan Huang, Xiaowen Fan, Jun Ying and Shiyao Chen

    Citation: Journal of Translational Medicine 2019 17:67

    Content type: Research

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  34. Glycolysis is altered in various kidney diseases, but little is known about glycolysis in pre-eclampsia, a multi-system disorder with major pathological effects on the kidney. Urinary exosomes provide a non-in...

    Authors: R. Ellis, M. Katerelos, S. W. Choy, N. Cook, M. Lee, K. Paizis, G. Pell, S. Walker, D. A. Power and P. F. Mount

    Citation: Journal of Translational Medicine 2019 17:60

    Content type: Research

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  35. Obesity is associated with impaired glucose tolerance which is a risk factor for cardiovascular risk. However, the oral glucose tolerance test (OGTT) is not usually performed in patients with normal fasting gl...

    Authors: Belén Pérez-Pevida, Jorge M. Núñez-Córdoba, Sonia Romero, Alexander Dimitri Miras, Patricia Ibañez, Neus Vila, María Ángeles Margall, Camilo Silva, Javier Salvador, Gema Frühbeck and Javier Escalada

    Citation: Journal of Translational Medicine 2019 17:48

    Content type: Research

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  36. Ischemia–reperfusion injury is caused by a period of ischemia followed by massive blood flow into a tissue that had experienced restricted blood flow. The severity of the injury is dependent on the time the ti...

    Authors: Michael D. Wetzel and Joseph C. Wenke

    Citation: Journal of Translational Medicine 2019 17:33

    Content type: Review

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  37. Early life is a period of drastic epigenetic remodeling in which the epigenome is especially sensitive to extrinsic and intrinsic influence. However, the epigenome-wide dynamics of the DNA methylation changes ...

    Authors: Raúl F. Pérez, Pablo Santamarina, Juan Ramón Tejedor, Rocío G. Urdinguio, Julio Álvarez-Pitti, Pau Redon, Agustín F. Fernández, Mario F. Fraga and Empar Lurbe

    Citation: Journal of Translational Medicine 2019 17:15

    Content type: Research

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  38. Intramuscular triglycerides (IMTGs) represent an important energy supply and a dynamic fat-storage depot that can expand during periods of elevated lipid availability and a fatty acid source. Ultrasonography (...

    Authors: Giovanni Tarantino, Susan Costantini, Vincenzo Citro, Paolo Conforti, Francesca Capone, Angela Sorice and Domenico Capone

    Citation: Journal of Translational Medicine 2019 17:8

    Content type: Research

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  39. Dysbiosis represents changes in composition and structure of the gut microbiome community (microbiome), which may dictate the physiological phenotype (health or disease). Recent technological advances and effo...

    Authors: Yuan-Yuan Chen, Dan-Qian Chen, Lin Chen, Jing-Ru Liu, Nosratola D. Vaziri, Yan Guo and Ying-Yong Zhao

    Citation: Journal of Translational Medicine 2019 17:5

    Content type: Review

    Published on:

  40. This systematic review and meta-analysis summarized the most recent evidence on the efficacy of intermittent energy restriction (IER) versus continuous energy restriction on weight-loss, body composition, bloo...

    Authors: Iolanda Cioffi, Andrea Evangelista, Valentina Ponzo, Giovannino Ciccone, Laura Soldati, Lidia Santarpia, Franco Contaldo, Fabrizio Pasanisi, Ezio Ghigo and Simona Bo

    Citation: Journal of Translational Medicine 2018 16:371

    Content type: Review

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  41. l-Fucose (Fuc), a six-deoxy hexose monosaccharide, is present endogenously in humans and animals and has a wide range of biological functions. In the present study, we aimed to examine the effect of Fuc on obes.....

    Authors: Guangyan Wu, Mengwei Niu, Wenli Tang, Jingjuan Hu, Guoquan Wei, Zhanke He, Yangping Chen, Yong Jiang and Peng Chen

    Citation: Journal of Translational Medicine 2018 16:344

    Content type: Research

    Published on:

  42. Endoplasmic reticulum (ER) stress, which can promote lipid metabolism disorders and steatohepatitis, contributes significantly to the pathogenesis of nonalcoholic fatty liver disease (NAFLD). Calcium (Ca2+) homeo...

    Authors: Xiaobo Gao, Shun Guo, Song Zhang, An Liu, Lei Shi and Yan Zhang

    Citation: Journal of Translational Medicine 2018 16:319

    Content type: Research

    Published on:

    The Correction to this article has been published in Journal of Translational Medicine 2019 17:277

  43. The cytokine, interleukin-18 (IL-18), was originally identified as an interferon-γ-inducing proinflammatory factor; however, there is increasing evidence suggesting that it has non-immunological effects on phy...

    Authors: Kyosuke Yamanishi, Seishi Maeda, Sachi Kuwahara-Otani, Takuya Hashimoto, Kaoru Ikubo, Keiichiro Mukai, Keiji Nakasho, Naomi Gamachi, Yosif El-Darawish, Wen Li, Daisuke Okuzaki, Yuko Watanabe, Hiromichi Yamanishi, Haruki Okamura and Hisato Matsunaga

    Citation: Journal of Translational Medicine 2018 16:314

    Content type: Research

    Published on:

  44. The Mediterranean diet (MeD) plays a key role in the prevention of obesity. Among the genes involved in obesity, the Fat mass and obesity-associated gene (FTO) is one of the most known, but its interaction wit...

    Authors: Laura Di Renzo, Giorgia Cioccoloni, Simone Falco, Ludovico Abenavoli, Alessandra Moia, Paola Sinibaldi Salimei and Antonino De Lorenzo

    Citation: Journal of Translational Medicine 2018 16:308

    Content type: Research

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  45. Insulin resistance and beta cell dysfunction were reported to be responsible for gestational diabetes mellitus (GDM). However, little is known about the heterogeneity of these factors and its influences on per...

    Authors: Yingfeng Liu, Wolin Hou, Xiyan Meng, Weijing Zhao, Jiemin Pan, Junling Tang, Yajuan Huang, Minfang Tao and Fang Liu

    Citation: Journal of Translational Medicine 2018 16:289

    Content type: Research

    Published on:

  46. Microbiota and bile acids in the gastrointestinal tract profoundly alter systemic metabolic processes. In obese subjects, gradual weight loss ameliorates adipose tissue inflammation and related systemic change...

    Authors: José O. Alemán, Nicholas A. Bokulich, Jonathan R. Swann, Jeanne M. Walker, Joel Correa De Rosa, Thomas Battaglia, Adele Costabile, Alexandros Pechlivanis, Yupu Liang, Jan L. Breslow, Martin J. Blaser and Peter R. Holt

    Citation: Journal of Translational Medicine 2018 16:244

    Content type: Research

    Published on:

  47. The developmental origins of health and disease theory states that a disturbance in the early life environment can contribute to disease risk in later life. Leptin and insulin are anorectic hormones involved i...

    Authors: Annette Vriens, Michelle Plusquin, Willy Baeyens, Liesbeth Bruckers, Elly Den Hond, Ilse Loots, Vera Nelen, Greet Schoeters, Bram G. Janssen and Tim S. Nawrot

    Citation: Journal of Translational Medicine 2018 16:224

    Content type: Research

    Published on:

  48. A characteristic feature of malignant cells, such as colorectal cancer cells, is a profound decrease in the level of 5-hydroxymethylcytosine, a product of 5-methylcytosine oxidation by TET enzymes. Recent stud...

    Authors: Marta Starczak, Ewelina Zarakowska, Martyna Modrzejewska, Tomasz Dziaman, Anna Szpila, Kinga Linowiecka, Jolanta Guz, Justyna Szpotan, Maciej Gawronski, Anna Labejszo, Ariel Liebert, Zbigniew Banaszkiewicz, Maria Klopocka, Marek Foksinski, Daniel Gackowski and Ryszard Olinski

    Citation: Journal of Translational Medicine 2018 16:204

    Content type: Research

    Published on:

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