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Nutrition & metabolism

Section edited by Laura Soldati

This section aims to provide a platform for the interaction and mutual validation between basic and applied research in the field of nutrition. In the area of Translational Medicine, we believe that the field ought to be taken into greater account in order to generate advanced applications for diagnosis and therapy and, at the same time, to develop new instruments of investigation.

Studies on all aspects of nutrition and metabolism with applications in medicine and biotechnology will be considered for publication. The section not only welcomes contributions that employ traditional clinical, metabolic and epidemiologic methods, but is also interested in molecular and cell biology applied to human and animal nutrition.

Featured articles

Hericium erinaceus mycelium and its isolated erinacine A protection from MPTP-induced neurotoxicity through the ER stress, triggering an apoptosis cascade
Hsing-Chun Kuo, et al

Obesity and colorectal cancer: molecular features of adipose tissue
Javier Martinez-Useros and Jesus Garcia-Foncillas



Role of a polyphenol-enriched preparation on chemoprevention of mammary carcinoma through cancer stem cells and inflammatory pathways modulation
Tri Vuong, et al

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  1. Fecal microbiota transplantation (FMT) is considered an effective treatment for slow transit constipation (STC); nevertheless, the mechanism remains unclear.

    Authors: Lulu Xie, Chen Xu, Yadong Fan, Yuwei Li, Ying Wang, Xiaoyu Zhang, Shuang Yu, Jida Wang, Rundong Chai, Zeyu Zhao, Yutong Jin, Zhe Xu, Shuwu Zhao and Yuhong Bian

    Citation: Journal of Translational Medicine 2021 19:490

    Content type: Research

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  2. Secretory phospholipase A2 group IIA (sPLA2-IIA) is an independent risk factor for cardiovascular disease, but its role on high-density lipoprotein cholesterol (HDL-C) level has not been clarified. The aim of ...

    Authors: Ling Liang, Qiang Xie, Changqing Sun, Yuanhui Wu, Wei Zhang and Weihua Li

    Citation: Journal of Translational Medicine 2021 19:484

    Content type: Research

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  3. Obesity is associated with chronic low-grade inflammation, contributing to an increasing prevalence of chronic metabolic diseases, such as insulin resistance, non-alcoholic fatty liver disease (NALFD), and ste...

    Authors: Jingchang Ma, Wei Hu, Dongliang Zhang, Jiangang Xie, Chujun Duan, Yitian Liu, Yuling Wang, Xuexue Xu, Kun Cheng, Boquan Jin, Yuan Zhang and Ran Zhuang

    Citation: Journal of Translational Medicine 2021 19:477

    Content type: Research

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  4. MicroRNA-146a-5p (miR-146a-5p) is a key regulator of inflammatory processes. Expression of miR-146a-5p is altered in target organs of diabetic complications and deficiency of miR-146a-5p has been implicated in...

    Authors: Federica Barutta, Beatrice Corbetta, Stefania Bellini, Simonetta Guarrera, Giuseppe Matullo, Michela Scandella, Casper Schalkwijk, Coen D. Stehouwer, Nish Chaturvedi, Sabita S. Soedamah-Muthu, Marilena Durazzo and Gabriella Gruden

    Citation: Journal of Translational Medicine 2021 19:475

    Content type: Research

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  5. It is well known that malnutrition is a frequent co-morbidity in cancer patients, especially in those with head and neck neoplasms. This may be due both to the presence of dysphagia symptoms and to the appeara...

    Authors: Maria Giulia Cristofaro, Ida Barca, Francesco Ferragina, Daniela Novembre, Yvelise Ferro, Roberta Pujia and Tiziana Montalcini

    Citation: Journal of Translational Medicine 2021 19:472

    Content type: Research

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  6. Diabetes mellitus (DM), a most common chronic disease, is featured with impaired endothelial function and bioavailability of nitric oxide (NO), while E3 ubiquitin ligase appears to alleviate endothelial dysfun...

    Authors: Qingsong Jin, Liangyan Lin, Tiantian Zhao, Xiaoyan Yao, Yaqin Teng, Dongdong Zhang, Yongjun Jin and Meizi Yang

    Citation: Journal of Translational Medicine 2021 19:469

    Content type: Research

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  7. Osteosarcoma (OS) is the most frequent primary bone cancer, affecting mostly children and adolescents. Although much progress has been made throughout the years towards treating primary OS, the 5-year survival...

    Authors: Taiana Campos Leite, Rebecca Jean Watters, Kurt Richard Weiss and Giuseppe Intini

    Citation: Journal of Translational Medicine 2021 19:450

    Content type: Review

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  8. Bitter taste-sensing type 2 receptors (TAS2Rs or T2Rs), belonging to the subgroup of family A G-protein coupled receptors (GPCRs), are of crucial importance in the perception of bitterness. Although in the fir...

    Authors: Kamila Tuzim and Agnieszka Korolczuk

    Citation: Journal of Translational Medicine 2021 19:440

    Content type: Review

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    The Correction to this article has been published in Journal of Translational Medicine 2021 19:478

  9. The number of older people is estimated to increase from 524 million in 2010 to 1.5 billion in 2050. The factors and models of human longevity and successful aging are questions that have intrigued individuals...

    Authors: Shihui Fu, Ping Ping, Yulong Li, Bo Li, Yali Zhao, Yao Yao and Pei Zhang

    Citation: Journal of Translational Medicine 2021 19:436

    Content type: Research

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  10. Human milk is a vehicle for bioactive compounds and beneficial bacteria which promote the establishment of a healthy gut microbiome of newborns, especially of preterm infants. Pasteurized donor human milk (PDH...

    Authors: D. Mallardi, C. Tabasso, P. Piemontese, S. Morandi, T. Silvetti, F. Biscarini, P. Cremonesi, B. Castiglioni, V. Pica, M. Stuknyte, I. De Noni, O. Amato, N. Liotto, F. Mosca and P. Roggero

    Citation: Journal of Translational Medicine 2021 19:420

    Content type: Research

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  11. Peritoneal dialysis (PD) is a form of dialysis to replace the function of kidney, that uses the peritoneum as a dialysis membrane to remove metabolites and water retained in the body. Vitamin D deficiency is p...

    Authors: Chi Zhang, Junsheng Wang, Xiaohui Xie and Dong Sun

    Citation: Journal of Translational Medicine 2021 19:411

    Content type: Research

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  12. Metabolism is one of the most complex cellular biochemical reactions, providing energy and substances for basic activities such as cell growth and proliferation. Early studies have shown that glucose is an imp...

    Authors: Beibei Luo, Xin Zhou, Qingming Tang, Ying Yin, Guangxia Feng, Shue Li and Lili Chen

    Citation: Journal of Translational Medicine 2021 19:410

    Content type: Review

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  13. Sphingosine Kinase (SphK) that catalyzes sphingosine (Sph) to sphingosine 1-phosphate (S1P), plays a key role in both sphingolipid metabolism and cellular signaling. While SphK has been implicated in type 2 di...

    Authors: Qi Chen, Wei Wang, Ming-Feng Xia, You-li Lu, Hua Bian, Chen Yu, Xiao-Ying Li, Mathew A. Vadas, Xin Gao, Huan-Dong Lin and Pu Xia

    Citation: Journal of Translational Medicine 2021 19:393

    Content type: Research

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  14. Gestational diabetes mellitus (GDM) is a serious public health issue affecting 9–15% of all pregnancies worldwide. Recently, it has been suggested that extracellular vesicles (EVs) play a role throughout gesta...

    Authors: Soumyalekshmi Nair, Dominic Guanzon, Nanthini Jayabalan, Andrew Lai, Katherin Scholz-Romero, Priyakshi Kalita de Croft, Valeska Ormazabal, Carlos Palma, Emilio Diaz, Elizabeth A. McCarthy, Alexis Shub, Jezid Miranda, Eduard Gratacós, Fátima Crispi, Gregory Duncombe, Martha Lappas…

    Citation: Journal of Translational Medicine 2021 19:360

    Content type: Research

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  15. Diabetic nephropathy (DN) is a leading cause of renal failure, whereas the effective and early diagnostic biomarkers are still lacking.

    Authors: Ye Feng, Xin Zhong, Hai-Feng Ni, Cui Wang, Tao-Tao Tang, Li-Ting Wang, Kai-Yun Song, Ri-Ning Tang, Hong Liu, Bi-Cheng Liu and Lin-Li Lv

    Citation: Journal of Translational Medicine 2021 19:355

    Content type: Research

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  16. Given the clinical low efficient treatment based on mono-brain-target design in Alzheimer’s disease (AD) and an increasing emphasis on microbiome-gut-brain axis which was considered as a crucial pathway to aff...

    Authors: Jie Gao, Nian Zhou, Yongkang Wu, Mengna Lu, Qixue Wang, Chenyi Xia, Mingmei Zhou and Ying Xu

    Citation: Journal of Translational Medicine 2021 19:351

    Content type: Research

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  17. The roles of FTO gene and the level of serum 25-OH-vitamin D in obesity are frequently reported. This study aimed to investigate the interactions of serum 25-OH-vitamin D level, FTO and IRX3 genes expression, ...

    Authors: Maryam Gholamalizadeh, Saeid Doaei, Zohreh Mokhtari, Vahideh Jalili, Fatemeh Bourbour, Saeed Omidi, Kamal Ebrahimi, Naser Kalantari, Sheyda Abdi, Ghasem Azizi Tabesh, Mohammad Naimi Joubani, Esmaeil Roohbakhsh and Seyed Alireza Mosavi Jarrahi

    Citation: Journal of Translational Medicine 2021 19:350

    Content type: Research

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  18. Chronotype is defined as a trait determining the subject circadian preference in behavioral and biological rhythms relative to external light–dark cycle. Although individual differences in chronotype have been...

    Authors: Luigi Barrea, Giovanna Muscogiuri, Gabriella Pugliese, Roberta Modica, Daniela Laudisio, Sara Aprano, Antongiulio Faggiano, Annamaria Colao and Silvia Savastano

    Citation: Journal of Translational Medicine 2021 19:324

    Content type: Research

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  19. Type 1 diabetes mellitus (T1DM) is a chronic autoimmune disease caused by severe loss of pancreatic β cells. Immune cells are key mediators of β cell destruction. This study attempted to investigate the role o...

    Authors: Jian Lin, Yuanhua Lu, Bizhou Wang, Ping Jiao and Jie Ma

    Citation: Journal of Translational Medicine 2021 19:319

    Content type: Research

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  20. Sarcopenia is a loss of muscle mass and strength causing disability, morbidity, and mortality in older adults, which is characterized by alterations of the neuromuscular junctions (NMJs). SNAP-25 is essential ...

    Authors: Simone Agostini, Roberta Mancuso, Andrea Saul Costa, Franca Rosa Guerini, Fabio Trecate, Rossella Miglioli, Elisabetta Menna, Beatrice Arosio and Mario Clerici

    Citation: Journal of Translational Medicine 2021 19:315

    Content type: Research

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  21. The coronavirus disease 2019 (COVID-19) pandemic has struck globally and is exerting a devastating toll on humans. The pandemic has led to calls for widespread vitamin D supplementation in public. However, evi...

    Authors: Zhiyong Cui and Yun Tian

    Citation: Journal of Translational Medicine 2021 19:300

    Content type: Research

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  22. Diabetic nephropathy (DN) has an increasing global prevalence with excessive health expenditure and burden. Exosomal mRNAs regulate intercellular communications and participate in the pathogenesis of various d...

    Authors: Ehsan Hashemi, Hojat Dehghanbanadaki, Alireza Abbasi Baharanchi, Katayoon Forouzanfar, Ardeshir Kakaei, Seyed Mohammad Mohammadi, Saba Zeidi and Farideh Razi

    Citation: Journal of Translational Medicine 2021 19:299

    Content type: Research

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  23. Subjects with chronic obstructive pulmonary disease (COPD) are prone to accelerated decay of muscle strength and mass with advancing age. This is believed to be driven by disease-inherent systemic pathophysiol...

    Authors: Knut Sindre Mølmen, Daniel Hammarström, Gunnar Slettaløkken Falch, Morten Grundtvig, Lise Koll, Marita Hanestadhaugen, Yusuf Khan, Rafi Ahmad, Bente Malerbakken, Tore Jørgen Rødølen, Roger Lien, Bent R. Rønnestad, Truls Raastad and Stian Ellefsen

    Citation: Journal of Translational Medicine 2021 19:292

    Content type: Research

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  24. Understanding the distinct patterns (trajectories) of variation in blood lipid levels before diagnosing cardiovascular disease (CVD) might carry important implications for improving disease prevention or treat...

    Authors: Fatemeh Koohi, Davood Khalili, Mohammad Ali Mansournia, Farzad Hadaegh and Hamid Soori

    Citation: Journal of Translational Medicine 2021 19:286

    Content type: Research

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  25. The association between serum advanced oxidation protein products (AOPP) and mortality risk remains equivocal. We aimed to assess the correlation of serum AOPP levels with the risk of all-cause mortality in he...

    Authors: Chun Zhou, Yuanyuan Zhang, Jianghua Chen, Changlin Mei, Fei Xiong, Wei Shi, Wei Zhou, Xusheng Liu, Shiren Sun, Jianwei Tian, Ziliang Ye, Qimeng Wu, Xianhui Qin, Jianping Jiang and Fan Fan Hou

    Citation: Journal of Translational Medicine 2021 19:284

    Content type: Research

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  26. Fasting plasma glucose (FPG) and 2-h post challenge plasma glucose (2 h-PCPG), whether as continuous or categorical variables, are associated with incident cardiovascular disease (CVD) and diabetes; however, t...

    Authors: Maryam Kabootari, Samaneh Asgari, Seyedeh Maryam Ghavam, Hengameh Abdi, Fereidoun Azizi and Farzad Hadaegh

    Citation: Journal of Translational Medicine 2021 19:277

    Content type: Research

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  27. Obstructive sleep apnea (OSA), a sleep disorder frequently observed in individuals living with obesity, consists of repeated involuntary breathing obstructions during sleep, leading to intermittent hypoxia (IH...

    Authors: Renée Morin, Jean-François Mauger, Ruwan Amaratunga and Pascal Imbeault

    Citation: Journal of Translational Medicine 2021 19:268

    Content type: Research

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  28. The hallmark of non-alcoholic fatty liver disease (NAFLD) is the excessive hepatic lipid accumulation. Currently, no pharmacotherapy exists for NAFLD. However, the glucagon-like peptide-1 receptor agonists hav...

    Authors: Khaoula Errafii, Neyla S. Al-Akl, Olfa Khalifa and Abdelilah Arredouani

    Citation: Journal of Translational Medicine 2021 19:235

    Content type: Research

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  29. Alcohol consumption is one of the modifiable risk factors for intracerebral hemorrhage, which accounts for approximately 10–20% of all strokes worldwide. We evaluated the association of stroke with genetic pol...

    Authors: Chun-Hsiang Lin, Oswald Ndi Nfor, Chien-Chang Ho, Shu-Yi Hsu, Disline Manli Tantoh, Yi-Chia Liaw, Mochly-Rosen Daria, Che-Hong Chen and Yung-Po Liaw

    Citation: Journal of Translational Medicine 2021 19:227

    Content type: Research

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  30. Until now, epidemiological evidence regarding the association between vitamin C intake (both diet and supplements) and Parkinson’s disease (PD) remains inconsistent. Hence, it is necessary to establish the cau...

    Authors: Haijie Liu, Yan Zhang, Haihua Zhang, Longcai Wang, Tao Wang, Zhifa Han, Liyong Wu and Guiyou Liu

    Citation: Journal of Translational Medicine 2021 19:221

    Content type: Research

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  31. The intestinal barrier plays an important role in the defense against infections, and nutritional, endocrine, and immune functions. The gut microbiota playing an important role in development of the gastrointe...

    Authors: Mariusz Kaczmarczyk, Ulrike Löber, Karolina Adamek, Dagmara Węgrzyn, Karolina Skonieczna-Żydecka, Damian Malinowski, Igor Łoniewski, Lajos Markó, Thomas Ulas, Sofia K. Forslund and Beata Łoniewska

    Citation: Journal of Translational Medicine 2021 19:177

    Content type: Research

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  32. sarcopenia is a highly prevalent condition in elderly individuals which is characterized by loss of muscle mass and functions; recent results showed that it is also associated with inflammation. Rehabilitation...

    Authors: Francesca La Rosa, Simone Agostini, Marina Saresella, Andrea Saul Costa, Federica Piancone, Rossella Miglioli, Fabio Trecate and Mario Clerici

    Citation: Journal of Translational Medicine 2021 19:172

    Content type: Research

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  33. Acne is a chronic, inflammatory and debilitating skin disorder. Dietary factors and nutritional status are among the exacerbating factors of acne. Phase angle (PhA), a direct measure of Bioelectrical Impedance...

    Authors: Luigi Barrea, Marianna Donnarumma, Sara Cacciapuoti, Giovanna Muscogiuri, Ludovica De Gregorio, Chiara Blasio, Silvia Savastano, Annamaria Colao and Gabriella Fabbrocini

    Citation: Journal of Translational Medicine 2021 19:171

    Content type: Research

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  34. Vitamin D status in patients with COVID-19 is an on-going controversial issue. This study aims to determine differences in the serum 25(OH)D concentrations of Arab Gulf adult residents screened for SARS-CoV-2 ...

    Authors: Nasser M. Al-Daghri, Osama E. Amer, Naif H. Alotaibi, Dara A. Aldisi, Mushira A. Enani, Eman Sheshah, Naji J. Aljohani, Naemah Alshingetti, Suliman Y. Alomar, Hanan Alfawaz, Syed D. Hussain, Abdullah M. Alnaami and Shaun Sabico

    Citation: Journal of Translational Medicine 2021 19:166

    Content type: Research

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  35. Dietary sulfur amino acid (SAA) restriction is an established animal model for increasing lifespan and improving metabolic health. Data from human studies are limited. In the study outlined in this protocol, w...

    Authors: Emma Stolt, Thomas Olsen, Amany Elshorbagy, Viktor Kožich, Marleen van Greevenbroek, Bente Øvrebø, Magne Thoresen, Helga Refsum, Kjetil Retterstøl and Kathrine J. Vinknes

    Citation: Journal of Translational Medicine 2021 19:153

    Content type: Protocol

    Published on:

  36. Nonalcoholic fatty liver disease (NAFLD) is a common metabolic disease that affects 20–30% of individuals worldwide. Liver puncture remains the gold standard for the diagnosis of liver diseases despite limitat...

    Authors: Cheng Hu, Tao Wang, Xiaoyu Zhuang, Qiaoli Sun, Xiaochun Wang, Hui Lin, Mingli Feng, Jiaqi Zhang, Qin Cao and Yuanye Jiang

    Citation: Journal of Translational Medicine 2021 19:152

    Content type: Research

    Published on:

  37. Time-restricted feeding (TRF) is a form of intermittent fasting, which is beneficial for weight loss and cardiometabolic health. Polycystic ovary syndrome (PCOS) is one of the most common reproductive endocrin...

    Authors: Chunzhu Li, Chuan Xing, Jiaqi Zhang, Han Zhao, Wenjing Shi and Bing He

    Citation: Journal of Translational Medicine 2021 19:148

    Content type: Research

    Published on:

  38. Coronavirus disease (COVID-19) pandemic has affected health and lifestyle behaviors of people globally. This project aims to identify the impact of COVID-19 on lifestyle behavior of individuals in the Middle E...

    Authors: Mohamed Abouzid, Dina M. El-Sherif, Nael Kamel Eltewacy, Nesrine Ben Hadj Dahman, Salah A. Okasha, Sherief Ghozy and Sheikh Mohammed Shariful Islam

    Citation: Journal of Translational Medicine 2021 19:129

    Content type: Research

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  39. Omega-3 polyunsaturated fatty acids (n3-PUFAs) may exert beneficial effects on the immune system of patients with viral infections. This paper aimed to examine the effect of n3-PUFA supplementation on inflamma...

    Authors: Saeid Doaei, Somayeh Gholami, Samira Rastgoo, Maryam Gholamalizadeh, Fatemeh Bourbour, Seyedeh Elaheh Bagheri, Forough Samipoor, Mohammad Esmail Akbari, Mahdi Shadnoush, Fereshteh Ghorat, Seyed Alireza Mosavi Jarrahi, Narjes Ashouri Mirsadeghi, Azadeh Hajipour, Parvin Joola, Alireza Moslem and Mark O. Goodarzi

    Citation: Journal of Translational Medicine 2021 19:128

    Content type: Research

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    The Letter to the Editor to this article has been published in Journal of Translational Medicine 2021 19:282

  40. Muscle wasting, low protein intake, hypoalbuminemia, low body mass, and chronic fatigue are prevalent in hemodialysis patients. Impaired creatine status may be an often overlooked, potential contributor to the...

    Authors: Adrian Post, Joëlle C. Schutten, Daan Kremer, Yvonne van der Veen, Dion Groothof, Camilo G. Sotomayor, Christa A. Koops, Pim de Blaauw, Ido P. Kema, Ralf Westerhuis, Theo Wallimann, M. Rebecca Heiner-Fokkema, Stephan J. L. Bakker and Casper F. M. Franssen

    Citation: Journal of Translational Medicine 2021 19:115

    Content type: Research

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  41. Non-alcoholic steatohepatitis (NASH) is a key stage in leading development of non-alcoholic simple fatty liver (NAFL) into cirrhosis and even liver cancer. This study aimed at exploring the lncRNAs expression ...

    Authors: Liangying Ye, Dan Zhao, Yangzhi Xu, Jiaen Lin, Jiahui Xu, Kunyuan Wang, Zhanhui Ye, Yufeng Luo, Shiming Liu and Hui Yang

    Citation: Journal of Translational Medicine 2021 19:101

    Content type: Research

    Published on:

  42. To identify sex specific trajectories of waist circumference (WC),triglyceride (TG), total cholesterol (TC), high density lipoprotein cholesterol (HDL-C) and fasting plasma glucose (FPG) during adulthood and e...

    Authors: Noushin Sadat Ahanchi, Seyed Saeed Tamehri Zadeh, Davood Khalili, Fereidoun Azizi and Farzad Hadaegh

    Citation: Journal of Translational Medicine 2021 19:84

    Content type: Research

    Published on:

  43. Non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH) are highly prevalent comorbidities in patients with Type 2 diabetes. While many of these patients eventually will need treatme...

    Authors: Victoria Svop Jensen, Christian Fledelius, Christina Zachodnik, Jesper Damgaard, Helle Nygaard, Kristina Steinicke Tornqvist, Rikke Kaae Kirk, Birgitte Martine Viuff, Erik Max Wulff, Jens Lykkesfeldt and Henning Hvid

    Citation: Journal of Translational Medicine 2021 19:80

    Content type: Research

    Published on:

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