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Cancer Metabolism

Section edited by Violena Pietrobon

© © natali_mis / stock.adobeTumor cells reprogram nutrient acquisition and metabolic pathways to support abnormal growth and metastasis, a dysfunctional process that is a hallmark of cancer. 

The Cancer Metabolism section will offer a solid framework to promote and disseminate innovative studies examining metabolic reprogramming in cancer cells, including fatty acid, mitochondrial, glycolytic and other metabolic networks.

We are interested in research that investigates and characterizes metabolic alterations in tumors at the molecular level by explaining why this reprogramming occurs and identifying links between such phenomena and cell proliferation and metastasis. We will also consider studies regarding the correlation between genomic mutations, gene expression, epigenetic regulation and metabolic pathway alterations. Of particular interest are investigations focused on translational and clinical aspects and those regarding metabolically targeted pharmacological therapies, with emphasis on patient responsiveness.

  1. Glycolysis affects tumor growth, invasion, chemotherapy resistance, and the tumor microenvironment. In this study, we aimed to construct a glycolysis-related prognostic model for ovarian cancer and analyze its...

    Authors: Jianlei Bi, Fangfang Bi, Xue Pan and Qing Yang

    Citation: Journal of Translational Medicine 2021 19:382

    Content type: Research

    Published on:

  2. Angiogenesis is the process of capillary sprouting from pre-existing vessels and it plays a critical role in the carcinogenic process of lung adenocarcinoma (LUAD). However, the association of angiogenesis reg...

    Authors: Songhua Cai, Xiaotong Guo, Chujian Huang, Youjun Deng, Longde Du, Wenyi Liu, Chenglin Yang, Hongbo Zhao, Kai Ma, Lixu Wang, Jie He and Zhentao Yu

    Citation: Journal of Translational Medicine 2021 19:361

    Content type: Research

    Published on:

  3. Accumulating evidence highlights the critical roles of fibroblast growth factors (FGFs) in regulating the progression of multiple human cancers, including non-small cell lung cancer (NSCLC). In this study, we ...

    Authors: Xiaowei Wu, Minjie Li, Ying Li, Yu Deng, Shun Ke, Fan Li, Yujin Wang and Shuchang Zhou

    Citation: Journal of Translational Medicine 2021 19:353

    Content type: Research

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  4. Tumor-associated macrophages (TAM) are immunosuppressive cells that contribute to impaired anti-cancer immunity. Iron plays a critical role in regulating macrophage function. However, it is still elusive wheth...

    Authors: Jia-Lei Sun, Ning-Ping Zhang, Ru-Chen Xu, Guang-Cong Zhang, Zhi-Yong Liu, Weinire Abuduwaili, Fu Wang, Xiang-Nan Yu, Xuan Shi, Guang-Qi Song, Hao Wu, Tao-Tao Liu, Xi-Zhong Shen, Bin Deng, Shu-Qiang Weng, Ling Dong…

    Citation: Journal of Translational Medicine 2021 19:347

    Content type: Research

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  5. Metabolic reprograming have been associated with cancer occurrence and progression within the tumor immune microenvironment. However, the prognostic potential of metabolism-related genes in colorectal cancer (...

    Authors: Dagui Lin, Wenhua Fan, Rongxin Zhang, Enen Zhao, Pansong Li, Wenhao Zhou, Jianhong Peng and Liren Li

    Citation: Journal of Translational Medicine 2021 19:279

    Content type: Research

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  6. Currently, no molecular classification is established for bladder cancer based on metabolic characteristics. Therefore, we conducted a comprehensive analysis of bladder cancer metabolism-related genes using mu...

    Authors: Chaozhi Tang, Meng Yu, Jiakang Ma and Yuyan Zhu

    Citation: Journal of Translational Medicine 2021 19:205

    Content type: Research

    Published on:

  7. Liver fibrosis occurs in response to any etiology of chronic liver injury. Lack of appropriate clinical intervention will lead to liver cirrhosis or hepatocellular carcinoma (HCC), seriously affecting the qual...

    Authors: Jingyao Cai, Min Hu, Zhiyang Chen and Zeng Ling

    Citation: Journal of Translational Medicine 2021 19:186

    Content type: Review

    Published on: