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Cancer Metabolism

Section edited by Violena Pietrobon

© © natali_mis / stock.adobeTumor cells reprogram nutrient acquisition and metabolic pathways to support abnormal growth and metastasis, a dysfunctional process that is a hallmark of cancer. 

The Cancer Metabolism section will offer a solid framework to promote and disseminate innovative studies examining metabolic reprogramming in cancer cells, including fatty acid, mitochondrial, glycolytic and other metabolic networks.

We are interested in research that investigates and characterizes metabolic alterations in tumors at the molecular level by explaining why this reprogramming occurs and identifying links between such phenomena and cell proliferation and metastasis. We will also consider studies regarding the correlation between genomic mutations, gene expression, epigenetic regulation and metabolic pathway alterations. Of particular interest are investigations focused on translational and clinical aspects and those regarding metabolically targeted pharmacological therapies, with emphasis on patient responsiveness.

  1. Prostatic cancer (PCa) is one of the most common malignant tumors in men worldwide. Emerging evidence indicates significance of hypoxia and immunity in PCa invasion and metastasis. This study aimed to develop ...

    Authors: Fang Lyu, Yunxue Li, Zhecheng Yan, Qingliu He, Lulin Cheng, Pu Zhang, Bing Liu, Chunyu Liu, Yarong Song and Yifei Xing
    Citation: Journal of Translational Medicine 2022 20:202
  2. 90% of esophageal cancer are esophageal squamous cell carcinoma (ESCC) and ESCC has a very poor prognosis and high mortality. Nevertheless, the key metabolic pathways associated with ESCC progression haven’t b...

    Authors: Tao Yang, Ruting Hui, Jessica Nouws, Maor Sauler, Tianyang Zeng and Qingchen Wu
    Citation: Journal of Translational Medicine 2022 20:127
  3. Targeting glutamine metabolism is previously indicated as a potential and attractive strategy for gastric cancer (GC) therapy. However, the underlying mechanisms responsible for the modification of glutamine m...

    Authors: Haofeng Liu, Qiu Xue, Hongzhou Cai, Xiaohui Jiang, Guangxin Cao, Tie Chen, Yuan Chen and Ding Wang
    Citation: Journal of Translational Medicine 2022 20:120
  4. Colorectal cancer (CRC) is one of the lethal cancers with a high mortality rate worldwide and understanding the mechanisms behind its progression is critical for improving patients’ prognosis and developing th...

    Authors: Yu Liu, Wentao Tang, Li Ren, Tianyu Liu, Meng Yang, Ye Wei, Yijiao Chen, Meiling Ji, Guosong Chen, Wenju Chang and Jianmin Xu
    Citation: Journal of Translational Medicine 2022 20:106
  5. The tumor microenvironment (TME) plays an important role in the occurrence and development of gastric cancer (GC) and is widely used to assess the treatment outcomes of GC patients. Immunohistochemistry (IHC) ...

    Authors: Tao Chen, Xunjun Li, Qingyi Mao, Yiyun Wang, Hanyi Li, Chen Wang, Yuyang Shen, Erjia Guo, Qinglie He, Jie Tian, Mansheng Zhu, Jing Wu, Weiqi Liang, Hao Liu, Jiang Yu and Guoxin Li
    Citation: Journal of Translational Medicine 2022 20:100
  6. Lung cancer remains a huge challenge to public health because of its high incidence and mortality, and lung adenocarcinoma (LUAD) is the main subtype of lung cancer. Hypoxia-induced vascular endothelial growth...

    Authors: Zhi Xia, Jian Xiao, Ziyu Dai and Qiong Chen
    Citation: Journal of Translational Medicine 2022 20:72
  7. Cutaneous melanoma exhibits heterogeneous metastatic patterns and prognosis. In this regard, liver metastasis, which is detected in ~ 10–20% of stage 4 patients, came to the fore of melanoma research, as it re...

    Authors: Sebastian A. Wohlfeil, Verena Häfele, Bianca Dietsch, Céline Weller, Carsten Sticht, Anna Sophia Jauch, Manuel Winkler, Christian David Schmid, Anna Lena Irkens, Ana Olsavszky, Kai Schledzewski, Philipp-Sebastian Reiners-Koch, Sergij Goerdt and Cyrill Géraud
    Citation: Journal of Translational Medicine 2022 20:62
  8. Loss-of-function mutations or abnormal expressions of E ubiquitin ligases contributes to tumorigenesis. TRIM38 was reported to regulate immunity, inflammatory responses or apoptosis, but its roles in tumor pro...

    Authors: Xiaojing Wang, Hongchao He, Wenbin Rui, Ning Zhang, Yu Zhu and Xin Xie
    Citation: Journal of Translational Medicine 2021 19:508
  9. Prostate cancer (PCa) belongs to an epithelial malignancy that occurs in the prostate gland and is the most common malignancy of the male genitourinary system. Referring to related literature, circSERPINA3 has...

    Authors: Zengshu Xing, Sailian Li, Zhenxiang Liu, Chong Zhang and Zhiming Bai
    Citation: Journal of Translational Medicine 2021 19:492
  10. Glycolysis affects tumor growth, invasion, chemotherapy resistance, and the tumor microenvironment. In this study, we aimed to construct a glycolysis-related prognostic model for ovarian cancer and analyze its...

    Authors: Jianlei Bi, Fangfang Bi, Xue Pan and Qing Yang
    Citation: Journal of Translational Medicine 2021 19:382
  11. Angiogenesis is the process of capillary sprouting from pre-existing vessels and it plays a critical role in the carcinogenic process of lung adenocarcinoma (LUAD). However, the association of angiogenesis reg...

    Authors: Songhua Cai, Xiaotong Guo, Chujian Huang, Youjun Deng, Longde Du, Wenyi Liu, Chenglin Yang, Hongbo Zhao, Kai Ma, Lixu Wang, Jie He and Zhentao Yu
    Citation: Journal of Translational Medicine 2021 19:361
  12. Accumulating evidence highlights the critical roles of fibroblast growth factors (FGFs) in regulating the progression of multiple human cancers, including non-small cell lung cancer (NSCLC). In this study, we ...

    Authors: Xiaowei Wu, Minjie Li, Ying Li, Yu Deng, Shun Ke, Fan Li, Yujin Wang and Shuchang Zhou
    Citation: Journal of Translational Medicine 2021 19:353
  13. Tumor-associated macrophages (TAM) are immunosuppressive cells that contribute to impaired anti-cancer immunity. Iron plays a critical role in regulating macrophage function. However, it is still elusive wheth...

    Authors: Jia-Lei Sun, Ning-Ping Zhang, Ru-Chen Xu, Guang-Cong Zhang, Zhi-Yong Liu, Weinire Abuduwaili, Fu Wang, Xiang-Nan Yu, Xuan Shi, Guang-Qi Song, Hao Wu, Tao-Tao Liu, Xi-Zhong Shen, Bin Deng, Shu-Qiang Weng, Ling Dong…
    Citation: Journal of Translational Medicine 2021 19:347
  14. Metabolic reprograming have been associated with cancer occurrence and progression within the tumor immune microenvironment. However, the prognostic potential of metabolism-related genes in colorectal cancer (...

    Authors: Dagui Lin, Wenhua Fan, Rongxin Zhang, Enen Zhao, Pansong Li, Wenhao Zhou, Jianhong Peng and Liren Li
    Citation: Journal of Translational Medicine 2021 19:279
  15. Currently, no molecular classification is established for bladder cancer based on metabolic characteristics. Therefore, we conducted a comprehensive analysis of bladder cancer metabolism-related genes using mu...

    Authors: Chaozhi Tang, Meng Yu, Jiakang Ma and Yuyan Zhu
    Citation: Journal of Translational Medicine 2021 19:205
  16. Liver fibrosis occurs in response to any etiology of chronic liver injury. Lack of appropriate clinical intervention will lead to liver cirrhosis or hepatocellular carcinoma (HCC), seriously affecting the qual...

    Authors: Jingyao Cai, Min Hu, Zhiyang Chen and Zeng Ling
    Citation: Journal of Translational Medicine 2021 19:186