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ImmunoVirology and ImmunoOncology

Section edited by Luigi Buonaguro and Maria Tagliamonte

The ImmunoVirology and ImmunoOncology section focuses on translational research related to immunity to viral-related or cancer-related diseases.

Studies focused on the role of innate, as well as adaptive, immunity in the establishment, containment and/or progression of viral infections as well as of cancers, including preventive or therapeutic vaccines, adjuvanting strategies and adoptive cell therapies will be considered for publication. Classic immunology as well as up-to-date "omics" approaches (genomics, proteomics, proteogenomics, immunogenomics, pharmacogenomics) will be considered.
 

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  1. Although it is becoming evident that individual’s immune system has a decisive influence on SARS-CoV-2 disease progression, pathogenesis is largely unknown. In this study, we aimed to profile the host transcri...

    Authors: Abul Bashar Mir Md. Khademul Islam, Md. Abdullah-Al-Kamran Khan, Rasel Ahmed, Md. Sabbir Hossain, Shah Md. Tamim Kabir, Md. Shahidul Islam and A. M. A. M. Zonaed Siddiki
    Citation: Journal of Translational Medicine 2021 19:32
    Content type: Research Published on:

  2. COVID-19 has caused a global pandemic and the death toll is increasing. However, there is no definitive information regarding the type of clinical specimens that is the best for SARS-CoV-2 detection, the antib...

    Authors: Ling Li, Chianru Tan, Jia Zeng, Chen Luo, Shi Hu, Yanke Peng, Wenjuan Li, Zhixiong Xie, Yueming Ling, Xuejun Zhang, E. Deng, Haixia Xu, Jue Wang, Yudi Xie, Yaling Zhou, Wei Zhang…
    Citation: Journal of Translational Medicine 2021 19:30
    Content type: Research Published on:

  3. The tumor immunological microenvironment (TIME) has a prominent impact on prognosis and immunotherapy. However, the heterogeneous TIME and the mechanisms by which TIME affects immunotherapy have not been eluci...

    Authors: Zaoqu Liu, Yuyuan Zhang, Chengcheng Shi, Xueliang Zhou, Kaihao Xu, Dechao Jiao, Zhenqiang Sun and Xinwei Han
    Citation: Journal of Translational Medicine 2021 19:5
    Content type: Research Published on:

  4. Tracking the genetic variability of Severe Acute Respiratory Syndrome CoronaVirus 2 (SARS-CoV-2) is a crucial challenge. Mainly to identify target sequences in order to generate robust vaccines and neutralizin...

    Authors: Alice Massacci, Eleonora Sperandio, Lorenzo D’Ambrosio, Mariano Maffei, Fabio Palombo, Luigi Aurisicchio, Gennaro Ciliberto and Matteo Pallocca
    Citation: Journal of Translational Medicine 2020 18:494
    Content type: Research Published on:

  5. In 1918 an unknown infectious agent spread around the world infecting over one-third of the general population and killing almost 50 million people. Many countries were at war, the First World War. Since Spain...

    Authors: Raffaele Scarpa, Francesco Caso, Luisa Costa, Saverio Passavanti, Maria Grazia Vitale, Claudia Trojaniello, Antonio Del Puente and Paolo A. Ascierto
    Citation: Journal of Translational Medicine 2020 18:489
    Content type: Review Published on:

  6. Although immune modulation is a promising therapeutic avenue in coronavirus disease 2019 (COVID-19), the most relevant targets remain to be found. COVID-19 has peculiar characteristics and outcomes, suggesting...

    Authors: Mathieu Blot, Jean-Baptiste Bour, Jean Pierre Quenot, Abderrahmane Bourredjem, Maxime Nguyen, Julien Guy, Serge Monier, Marjolaine Georges, Audrey Large, Auguste Dargent, Alexandre Guilhem, Suzanne Mouries-Martin, Jeremy Barben, Belaid Bouhemad, Pierre-Emmanuel Charles, Pascal Chavanet…
    Citation: Journal of Translational Medicine 2020 18:457
    Content type: Research Published on:

    The Correction to this article has been published in Journal of Translational Medicine 2021 19:100

  7. The restoration of host hepatitis B virus (HBV)-specific antiviral immunity is an effective strategy for hepatitis B recovery. Follicular dendritic cells (FDCs) play a crucial role in immune regulation. The go...

    Authors: Xiaoyi Li, Qifan Zhang, Wanyue Zhang, Guofu Ye, Yanchen Ma, Chunhua Wen, Shuqin Gu, Libo Tang and Yongyin Li
    Citation: Journal of Translational Medicine 2020 18:417
    Content type: Research Published on:

  8. Since the first outbreak of SARS-CoV-2, the clinical characteristics of the Coronavirus Disease 2019 (COVID-19) have been progressively changed. Data reporting a viral intra-host and inter-host evolution favou...

    Authors: Francesca Caccuri, Alberto Zani, Serena Messali, Marta Giovanetti, Antonella Bugatti, Giovanni Campisi, Federica Filippini, Erika Scaltriti, Massimo Ciccozzi, Simona Fiorentini and Arnaldo Caruso
    Citation: Journal of Translational Medicine 2020 18:362
    Content type: Research Published on:

  9. COVID-19 caused by a novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) originated in Wuhan (Hubei province, China) during late 2019. It has spread across the globe affecting nearly 21 million ...

    Authors: Sina Salajegheh Tazerji, Phelipe Magalhães Duarte, Parastoo Rahimi, Fatemeh Shahabinejad, Santosh Dhakal, Yashpal Singh Malik, Awad A. Shehata, Juan Lama, Jörn Klein, Muhammad Safdar, Md. Tanvir Rahman, Krzysztof J. Filipiak, Alfonso J. Rodríguez-Morales, Md. Abdus Sobur, Farrokhreza Kabir, Bita Vazir…
    Citation: Journal of Translational Medicine 2020 18:358
    Content type: Review Published on:

  10. The outbreak of Coronavirus disease of 2019 (COVID-19) caused by the Severe Acute Respiratory Syndrome coronavirus 2 (SARS-CoV-2), has posed a serious health threat. The increasing number of COVID-19 cases aro...

    Authors: Manoj Kumar and Souhaila Al Khodor
    Citation: Journal of Translational Medicine 2020 18:353
    Content type: Review Published on:

  11. Understanding how HLA polymorphisms may affect both susceptibility, course and severity of Covid-19 infection could help both at the clinical level to identify individuals at higher risk from the disease and a...

    Authors: Simona Pisanti, Joris Deelen, Anna Maria Gallina, Mariella Caputo, Marianna Citro, Mario Abate, Nicoletta Sacchi, Carmine Vecchione and Rosanna Martinelli
    Citation: Journal of Translational Medicine 2020 18:352
    Content type: Research Published on:

  12. The new Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2), which was first detected in Wuhan (China) in December of 2019 is responsible for the current global pandemic. Phylogenetic analysis reveale...

    Authors: Francesca Benedetti, Greg A. Snyder, Marta Giovanetti, Silvia Angeletti, Robert C. Gallo, Massimo Ciccozzi and Davide Zella
    Citation: Journal of Translational Medicine 2020 18:329
    Content type: Research Published on:

  13. Liver cancer is among the most common malignancy worldwide. Hepatocellular carcinoma (HCC), the principal histological subtype of liver cancer, is globally the third most common cause of cancer-related mortali...

    Authors: Xia Qin, Jian Zhang, Yu Lin, Xue-ming Sun, Jia-ning Zhang and Zhi-qiang Cheng
    Citation: Journal of Translational Medicine 2020 18:326
    Content type: Research Published on:

  14. In less than 20 years, three deadly coronaviruses, SARS-CoV, MERS-CoV and SARS-CoV-2, have emerged in human population causing hundreds to hundreds of thousands of deaths. Other coronaviruses are causing epizo...

    Authors: Laure Perrin-Cocon, Olivier Diaz, Clémence Jacquemin, Valentine Barthel, Eva Ogire, Christophe Ramière, Patrice André, Vincent Lotteau and Pierre-Olivier Vidalain
    Citation: Journal of Translational Medicine 2020 18:319
    Content type: Review Published on:

  15. HIV-1 Vpr encodes a 14 kDa protein that has been implicated in viral pathogenesis through modulation of several host cell functions. In addition to pro-apoptotic and cytostatic properties, Vpr can redirect cel...

    Authors: Patrick Eldin, Sophie Péron, Anastasia Galashevskaya, Nicolas Denis-Lagache, Michel Cogné, Geir Slupphaug and Laurence Briant
    Citation: Journal of Translational Medicine 2020 18:310
    Content type: Research Published on:

  16. In the past decade, cervical cancer has gone from being the second to the fourth most common cancer in women worldwide, but remains the second most common in developing countries. This cancer is most commonly ...

    Authors: Elham Hassen, Devendra Bansal, Randa Ghdira, Anouar Chaieb, Hedi Khairi, Abdelfattah Zakhama, Sami Remadi, Johan Hoebeke, Ali A. Sultan and Lotfi Chouchane
    Citation: Journal of Translational Medicine 2020 18:288
    Content type: Research Published on:

  17. The recent outbreak by SARS-CoV-2 has generated a chaos in global health and economy and claimed/infected a large number of lives. Closely resembling with SARS CoV, the present strain has manifested exceptiona...

    Authors: Amrita Banerjee, Dipannita Santra and Smarajit Maiti
    Citation: Journal of Translational Medicine 2020 18:281
    Content type: Research Published on:

  18. Severe acute respiratory syndrome (SARS) has been initiating pandemics since the beginning of the century. In December 2019, the world was hit again by a devastating SARS episode that has so far infected almos...

    Authors: Nitin Chitranshi, Vivek K. Gupta, Rashi Rajput, Angela Godinez, Kanishka Pushpitha, Ting Shen, Mehdi Mirzaei, Yuyi You, Devaraj Basavarajappa, Veer Gupta and Stuart L. Graham
    Citation: Journal of Translational Medicine 2020 18:278
    Content type: Research Published on:

  19. The genomic alterations of intrahepatic cholangiocarcinoma (ICC) in the Chinese population have not been fully revealed. Molecular profiling may provide a reference for clinical management, especially targeted...

    Authors: Longrong Wang, Hongxu Zhu, Yiming Zhao, Qi Pan, Anrong Mao, Weiping Zhu, Ning Zhang, Zhenhai Lin, Jiamin Zhou, Yilin Wang, Yongfa Zhang, Miao Wang, Yun Feng, Xigan He, Weiqi Xu and Lu Wang
    Citation: Journal of Translational Medicine 2020 18:273
    Content type: Research Published on:

  21. The novel coronavirus disease 2019 (COVID-19) broke out globally. Early prediction of the clinical progression was essential but still unclear. We aimed to evaluate the timeline of COVID-19 development and ana...

    Authors: Fang Wang, Mengyuan Qu, Xuan Zhou, Kai Zhao, Changxiang Lai, Qiyuan Tang, Wenjie Xian, Ruikun Chen, Xuan Li, Zhiyu Li, Qing He and Lei Liu
    Citation: Journal of Translational Medicine 2020 18:270
    Content type: Research Published on:

  22. With the aim of providing a dynamic evaluation of the effects of basic environmental parameters on COVID-19-related death rate, we assessed the correlation between average monthly high temperatures and populat...

    Authors: Francesca Benedetti, Maria Pachetti, Bruna Marini, Rudy Ippodrino, Robert C. Gallo, Massimo Ciccozzi and Davide Zella
    Citation: Journal of Translational Medicine 2020 18:251
    Content type: Research Published on:

  23. Post-transcriptional methylation modifications, including 5-methylcytosine (m5C) modification, are closely related to the tumorigenesis of cancers. However, the mRNA profile of m5C modification in hepatocellul...

    Authors: Qiyao Zhang, Qingyuan Zheng, Xiao Yu, Yuting He and Wenzhi Guo
    Citation: Journal of Translational Medicine 2020 18:245
    Content type: Research Published on:

  24. The persistence of HIV-1 in reservoir cells is one of the major obstacles to eradicating the virus in infected individuals receiving combination antiretroviral therapy (ART). HIV-1 persists in infected cells a...

    Authors: Chiara Orlandi, Benedetta Canovari, Federica Bozzano, Francesco Marras, Zeno Pasquini, Francesco Barchiesi, Andrea De Maria, Mauro Magnani and Anna Casabianca
    Citation: Journal of Translational Medicine 2020 18:204
    Content type: Research Published on:

  25. A new human coronavirus named SARS-CoV-2 was identified in several cases of acute respiratory syndrome in Wuhan, China in December 2019. On March 11 2020, WHO declared the SARS-CoV-2 infection to be a pandemic...

    Authors: Luigi Buonaguro, Maria Tagliamonte, Maria Lina Tornesello and Franco M. Buonaguro
    Citation: Journal of Translational Medicine 2020 18:185
    Content type: Commentary Published on:

  26. SARS-CoV-2 is a RNA coronavirus responsible for the pandemic of the Severe Acute Respiratory Syndrome (COVID-19). RNA viruses are characterized by a high mutation rate, up to a million times higher than that o...

    Authors: Maria Pachetti, Bruna Marini, Francesca Benedetti, Fabiola Giudici, Elisabetta Mauro, Paola Storici, Claudio Masciovecchio, Silvia Angeletti, Massimo Ciccozzi, Robert C. Gallo, Davide Zella and Rudy Ippodrino
    Citation: Journal of Translational Medicine 2020 18:179
    Content type: Research Published on:

  27. Early detection of treatment failure may improve clinical outcome and overall survival in patients with head and neck cancer after first-line treatment. Circulating cell-free HPV16 DNA (cfHPV16 DNA) was evalua...

    Authors: Tomasz W. Rutkowski, Agnieszka M. Mazurek, Mirosław Śnietura, Beata Hejduk, Maja Jędrzejewska, Barbara Bobek-Billewicz, Andrea d’Amico, Wojciech Pigłowski, Andrzej Wygoda, Krzysztof Składowski, Zofia Kołosza and Piotr Widłak
    Citation: Journal of Translational Medicine 2020 18:167
    Content type: Research Published on:

  28. Hepatitis B virus (HBV) remains a major cause of chronic hepatitis and hepatocellular carcinoma, and miRNAs play important roles in HBV pathogenesis. Our previous study has shown that miR-328-3p is upregulated...

    Authors: Xiaoyu Fu, Yi Ouyang, Juan Mo, Ronghua Li, Lei Fu and Shifang Peng
    Citation: Journal of Translational Medicine 2020 18:143
    Content type: Research Published on:

  29. The global burden of hepatitis B virus (HBV) infection in terms of morbidity and mortality is immense. Novel treatments that can induce a protective immune response are urgently needed to effectively control t...

    Authors: Yunlong Hu, Li Tang, Zhengyu Zhu, He Meng, Tingting Chen, Sheng Zhao, Zhenchao Jin, Zhulin Wang and Guangyi Jin
    Citation: Journal of Translational Medicine 2020 18:112
    Content type: Research Published on:

  30. Disease progression in the absence of therapy varies significantly in mono-HIV and HCV infected individuals. Virus-specific CD8+ T cells play an important role in restricting lentiviral replication and determinin...

    Authors: Si-Yao Li, Zi-Ning Zhang, Yong‑Jun Jiang, Ya‑Jing Fu and Hong Shang
    Citation: Journal of Translational Medicine 2020 18:96
    Content type: Research Published on:

  31. Despite the effective antiretroviral treatment (ART) of HIV-infected individuals, HIV persists in a small pool. Central memory CD4+ T cells (Tcm) make a major contribution to HIV persistence. We found that unlike...

    Authors: Cheng-Bo Song, Le-Le Zhang, Xian Wu, Ya-Jing Fu, Yong-Jun Jiang, Hong Shang and Zi-Ning Zhang
    Citation: Journal of Translational Medicine 2020 18:95
    Content type: Research Published on:

  32. To explore the modulatory effects and mechanism of secretory clusterin (sCLU) on cancer stem cell (CSC) properties in hepatocellular carcinoma (HCC).

    Authors: Wenjie Zheng, Min Yao, Mengna Wu, Junling Yang, Dengfu Yao and Li Wang
    Citation: Journal of Translational Medicine 2020 18:81
    Content type: Research Published on:

  33. Growing evidence has suggested that immune-related genes play crucial roles in the development and progression of hepatocellular carcinoma (HCC). Nevertheless, the utility of immune-related genes for evaluatin...

    Authors: Zheng Wang, Jie Zhu, Yongjuan Liu, Changhong Liu, Wenqi Wang, Fengzhe Chen and Lixian Ma
    Citation: Journal of Translational Medicine 2020 18:67
    Content type: Research Published on:

  34. Hepatocellular carcinoma (HCC) is the most common type of liver tumour, and is closely related to liver cirrhosis. Previous studies have focussed on the pathogenesis of liver cirrhosis developing into HCC, but...

    Authors: Chen Hao Jiang, Xin Yuan, Jiang Fen Li, Yu Fang Xie, An Zhi Zhang, Xue Li Wang, Lan Yang, Chun Xia Liu, Wei Hua Liang, Li Juan Pang, Hong Zou, Xiao Bin Cui, Xi Hua Shen, Yan Qi, Jin Fang Jiang, Wen Yi Gu…
    Citation: Journal of Translational Medicine 2020 18:40
    Content type: Research Published on:

  35. Neuropsychiatric manifestations are frequent in patients with systemic lupus erythematosus (SLE), yet the etiology and pathogenesis of brain damage in SLE remains unclear. Because the production of autoantibod...

    Authors: Chunshu Yang, Xiaoyu Hou, Qianhui Feng, Yingzhuo Li, Xuejiao Wang, Ling Qin and Pingting Yang
    Citation: Journal of Translational Medicine 2019 17:426
    Content type: Research Published on:

  36. Polymorphonuclear (PMN) elastase plays an important role in a variety of inflammatory disorders. Our aim was to analyse PMN elastase in idiopathic inflammatory myopathies (IIMs) and its association with diseas...

    Authors: Siyu Wu, Wanchan Peng, Yunli Zhang, Jingjing Guo, Jinfang Fu and Wei Wang
    Citation: Journal of Translational Medicine 2019 17:420
    Content type: Research Published on:

  37. Accumulated studies reported abnormal gene expression profiles of hepatocellular carcinoma (HCC) by cDNA microarray. We tried to merge cDNA microarray data from different studies to search for stably changed g...

    Authors: Yufeng Sun, Wenchao Li, Shiqi Shen, Xuejing Yang, Bing Lu, Xiaojing Zhang, Peng Lu, Yi Shen and Juling Ji
    Citation: Journal of Translational Medicine 2019 17:390
    Content type: Research Published on:

  38. An unexpected increased HCC recurrence and occurrence rate among HCV patients treated with direct acting antivirals combination has been reported. Aim of the study was the evaluation of early HCC occurrence ra...

    Authors: Luca Rinaldi, Alessandro Perrella, Maria Guarino, Massimo De Luca, Guido Piai, Nicola Coppola, Pia Clara Pafundi, Fortunato Ciardiello, Morena Fasano, Erika Martinelli, Giovanna Valente, Riccardo Nevola, Caterina Monari, Lucia Miglioresi, Barbara Guerrera, Massimiliano Berretta…
    Citation: Journal of Translational Medicine 2019 17:292
    Content type: Research Published on:

  39. The sequential activation of immediate early (IE), early (E) and late (L) genes is required to allow productive herpes simplex virus type 1 (HSV-1) infection. Several evidences suggest that, together with infl...

    Authors: Francesca La Rosa, Simone Agostini, Anna Bianchi, Raffaello Nemni, Federica Piancone, Ivana Marventano, Roberta Mancuso, Marina Saresella and Mario Clerici
    Citation: Journal of Translational Medicine 2019 17:286
    Content type: Research Published on:

  40. Current human influenza vaccines lack the adaptability to match the mutational rate of the virus and therefore require annual revisions. Because of extensive manufacturing times and the possibility that antige...

    Authors: Patrick Tjok Joe, Ioanna Christopoulou, Lien van Hoecke, Bert Schepens, Tine Ysenbaert, Carlo Heirman, Kris Thielemans, Xavier Saelens and Joeri L. Aerts
    Citation: Journal of Translational Medicine 2019 17:242
    Content type: Research Published on:

  41. In non-human primates (NHPs) and humans, partial protection from HIV/SIV infection or suppression of replication is achievable by Env-binding antibodies and Gag-specific CD8+ T-cells targeting protective epito...

    Authors: Melanie Schwerdtfeger, Anne-Marie Carola Andersson, Lasse Neukirch and Peter Johannes Holst
    Citation: Journal of Translational Medicine 2019 17:175
    Content type: Research Published on:

  42. In human immunodeficiency virus (HIV) infection, 10–15% of individuals exhibit a rapid decline in CD4+ T cells and become rapid progressors (RPs). Overall, understanding the factors affecting rapid disease pro...

    Authors: Ying Pan, Zi-Ning Zhang, Lin-Bo Yin, Ya-Jing Fu, Yong-Jun Jiang and Hong Shang
    Citation: Journal of Translational Medicine 2019 17:167
    Content type: Research Published on:

  43. New and emerging transfusion–transmitted infections remain a threat to the blood supply. Blood donors are currently screened for less than half of known agents, primarily by individual tests. A screening platf...

    Authors: Valeria De Giorgi, Huizhi Zhou, Harvey J. Alter and Robert D. Allison
    Citation: Journal of Translational Medicine 2019 17:156
    Content type: Research Published on:

  44. Previous studies have identified IFNγ as an important early barrier to oncolytic viruses including vaccinia. The existing innate and adaptive immune barriers restricting oncolytic virotherapy, however, can be ...

    Authors: Dobrin D. Draganov, Antonio F. Santidrian, Ivelina Minev, Duong Nguyen, Mehmet Okyay Kilinc, Ivan Petrov, Anna Vyalkova, Elliot Lander, Mark Berman, Boris Minev and Aladar A. Szalay
    Citation: Journal of Translational Medicine 2019 17:100
    Content type: Research Published on:

    The Correction to this article has been published in Journal of Translational Medicine 2021 19:414

  46. Prostaglandin E receptor 2 (EP2) is an immune modulatory molecule that regulates the balance of immunity. Here we investigated the role of EP2 in immune dysregulation in patients with acute-on-chronic liver fa...

    Authors: Yunyun Wang, Chao Chen, Jinjin Qi, Fengtian Wu, Jun Guan, Zhi Chen and Haihong Zhu
    Citation: Journal of Translational Medicine 2019 17:93
    Content type: Research Published on:

  47. Infection with the hepatitis B virus (HBV) is an independent risk factor for liver cirrhosis and hepatocellular carcinoma, polymorphisms in HLA-DQB1 play an important role in HBV infections.

    Authors: Guojin Ou, Haixia Xu, Hao Yu, Xiao Liu, Liu Yang, Xin Ji, Jue Wang and Zhong Liu
    Citation: Journal of Translational Medicine 2018 16:362
    Content type: Research Published on:

  48. The mitochondrial DNA (mtDNA) seems to influence in a large number of diseases, including HIV infection. Moreover, there is a substantial inter-individual variability in the CD4+ recovery in HIV-infected patie...

    Authors: Luz M. Medrano, Mónica Gutiérrez-Rivas, Julià Blanco, Marcial García, María A. Jiménez-Sousa, Yolanda M. Pacheco, Marta Montero, José Antonio Iribarren, Enrique Bernal, Onofre Juan Martínez, José M. Benito, Norma Rallón and Salvador Resino
    Citation: Journal of Translational Medicine 2018 16:343
    Content type: Research Published on:

  49. Chikungunya virus (CHIKV), causes massive outbreaks of chikungunya infection in several regions of Asia, Africa and Central/South America. Being positive sense RNA virus, CHIKV replication within the host resu...

    Authors: Muhammad Tahir ul Qamar, Amna Bari, Muhammad Muzammal Adeel, Arooma Maryam, Usman Ali Ashfaq, Xiaoyong Du, Iqra Muneer, Hafiz Ishfaq Ahmad and Jia Wang
    Citation: Journal of Translational Medicine 2018 16:298
    Content type: Research Published on:

  50. Subclinical mastitis (SCM) is relatively common in lactating women and may be associated with HIV shedding in breast milk. The potential association between HIV infection and breast milk immunologic factors an...

    Authors: Roxane Schaub, Stéphanie Badiou, Johannes Viljoen, Pierre Dujols, Karine Bolloré, Philippe Van de Perre, Marie-Louise Newell, Ruth Bland, Nicolas Nagot and Edouard Tuaillon
    Citation: Journal of Translational Medicine 2018 16:296
    Content type: Research Published on:
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