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Section edited by Luigi Buonaguro

The Immunovirology section focuses on translational research related to virology and immunity to virus-based diseases, with a particular interest in human oncogenic viruses.

Studies focused on the role of innate, as well as adaptive, immunity in the establishment, containment and/or progression of viral infections up to cancer, including vaccine and adjuvanting strategies, will be considered for publication. Classic immunology as well as more recent, less established "omics" approaches (genomics, proteomics, immunogenomics, pharmacogenomics) will also be considered.

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  1. Content type: Research

    Mass cytometry, or CyTOF (Cytometry by Time-of-Flight), permits the simultaneous detection of over 40 phenotypic and functional immune markers in individual cells without the issues of spectral overlap seen in...

    Authors: Christine M. D. Lingblom, Sangeeta Kowli, Nithya Swaminathan, Holden T. Maecker and Stacie L. Lambert

    Citation: Journal of Translational Medicine 2018 16:153

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  2. Content type: Research

    The etiopathology of multiple sclerosis (MS) is believed to include genetic and environmental factors. Human leukocyte antigen (HLA) alleles, in particular,  are associated with disease susceptibility, whereas...

    Authors: Simone Agostini, Roberta Mancuso, Franca R. Guerini, Sandra D’Alfonso, Cristina Agliardi, Ambra Hernis, Milena Zanzottera, Nadia Barizzone, Maurizio A. Leone, Domenico Caputo, Marco Rovaris and Mario Clerici

    Citation: Journal of Translational Medicine 2018 16:80

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  3. Content type: Research

    NRTIs-sparing regimens exert favourable profiles on T-cell homeostasis associated parameters. Our aim was to analyze the effect of NRTIs sparing regimen (NRTI-sparing-cART) vs NRTIs-containing regimen (NRTI-cA...

    Authors: A. Gonzalez-Serna, S. Ferrando-Martinez, L. Tarancon-Diez, R. S. De Pablo-Bernal, B. Dominguez-Molina, J. L. Jiménez, M. Á. Muñoz-Fernández, M. Leal and E. Ruiz-Mateos

    Citation: Journal of Translational Medicine 2017 15:259

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  4. Content type: Research

    Anemia is frequent during HIV infection and is predictive of mortality. Although cART has demonstrated to reduce its prevalence, several patients still experience unresolved anemia. We aimed to characterize ir...

    Authors: Eugenia Quiros-Roldan, Francesco Castelli, Paola Lanza, Chiara Pezzoli, Marika Vezzoli, Giorgio Biasiotto and Isabella Zanella

    Citation: Journal of Translational Medicine 2017 15:256

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  5. Content type: Research

    There is limited information on innate immunity, especially natural killer (NK) cell function, in different chronic hepatitis B (CHB) stages. Therefore, we examined whether the clinical staging strategy accura...

    Authors: Xiaoyan Li, Liang Zhou, Lin Gu, Yurong Gu, Lubiao Chen, Yifan Lian and Yuehua Huang

    Citation: Journal of Translational Medicine 2017 15:220

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  6. Content type: Research

    A major obstacle for the development of HIV vaccines is the virus’ worldwide sequence diversity. Nevertheless, the presence of T cell epitopes within conserved regions of the virus’ structural Gag protein and ...

    Authors: Anne-Marie Carola Andersson and Peter Johannes Holst

    Citation: Journal of Translational Medicine 2016 14:343

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  7. Content type: Research

    The new microcapillary and fluorescence-based EC IVD-qualified Muse™ Auto CD4/CD4% single-platform assay (EMD Millipore Corporation, Merck Life Sciences, KGaA, Darmstadt, Germany) for CD4 T cell numeration in ...

    Authors: Christian Diamant Mossoro-Kpinde, André Kouabosso, Ralph-Sydney Mboumba Bouassa, Jean De Dieu Longo, Edouard Kokanzo, Rosine Féissona, Gérard Grésenguet and Laurent Bélec

    Citation: Journal of Translational Medicine 2016 14:326

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  8. Content type: Research

    Ebola virus (EBOV) is a Category A pathogen that is a member of Filoviridae family that causes hemorrhagic fever in humans and non-human primates. Unpredictable and devastating outbreaks of disease have recently ...

    Authors: Alfonso Rosamilia, Sarah Jacca, Giulia Tebaldi, Silvia Tiberti, Valentina Franceschi, Francesca Macchi, Sandro Cavirani, Gary Kobinger, Donald P. Knowles and Gaetano Donofrio

    Citation: Journal of Translational Medicine 2016 14:325

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  9. Content type: Research

    Many investigators detected the simian polyomavirus SV40 footprints in human brain tumors and neurologic diseases and recently it has been indicated that SV40 seems to be associated with multiple sclerosis (MS...

    Authors: Roberta Rizzo, Silvia Pietrobon, Elisa Mazzoni, Daria Bortolotti, Fernanda Martini, Massimiliano Castellazzi, Ilaria Casetta, Enrico Fainardi, Dario Di Luca, Enrico Granieri and Mauro Tognon

    Citation: Journal of Translational Medicine 2016 14:216

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  10. Content type: Methodology

    The FluoroSpot assay, an advancement of the ELISpot assay, enables simultaneous measurement of different analytes secreted at a single-cell level. This allows parallel detection of several cytokines secreted b...

    Authors: Nina Körber, Uta Behrends, Alexander Hapfelmeier, Ulrike Protzer and Tanja Bauer

    Citation: Journal of Translational Medicine 2016 14:175

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  11. Content type: Research

    We previously demonstrated that the HLA class II transactivator CIITA inhibits HIV-1 replication in T cells by competing with the viral transactivator Tat for the binding to Cyclin T1 subunit of the P-TEFb com...

    Authors: Greta Forlani, Filippo Turrini, Silvia Ghezzi, Alessandra Tedeschi, Guido Poli, Roberto S. Accolla and Giovanna Tosi

    Citation: Journal of Translational Medicine 2016 14:94

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  12. Content type: Research

    Autoimmune Addison’s disease (AAD) is caused by multiple genetic and environmental factors. Variants of genes encoding immunologically important proteins such as the HLA molecules are strongly associated with ...

    Authors: Kine Edvardsen, Alexander Hellesen, Eystein S. Husebye and Eirik Bratland

    Citation: Journal of Translational Medicine 2016 14:68

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  13. Content type: Research

    The tumor immunosuppressive microenvironment represents a major obstacle to an effective tumor-specific cellular immune response.

    Authors: Maria Tagliamonte, Annacarmen Petrizzo, Maria Napolitano, Antonio Luciano, Domenica Rea, Antonio Barbieri, Claudio Arra, Piera Maiolino, Marialina Tornesello, Gennaro Ciliberto, Franco M. Buonaguro and Luigi Buonaguro

    Citation: Journal of Translational Medicine 2016 14:58

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  14. Content type: Review

    Research challenges associated with understanding HIV persistence during antiretroviral therapy can be categorized as temporal, spatial and combinatorial. Temporal research challenges relate to the timing of e...

    Authors: Paul W. Denton, Ole S. Søgaard and Martin Tolstrup

    Citation: Journal of Translational Medicine 2016 14:44

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  15. Content type: Methodology

    Human myeloid-derived suppressor cells (MDSC) have been described as a group of immature myeloid cells which exert immunosuppressive action by inhibiting function of T lymphocytes. While there is a huge scient...

    Authors: Eva Grützner, Renate Stirner, Lukas Arenz, Anastasia P. Athanasoulia, Kathrin Schrödl, Carola Berking, Johannes R. Bogner and Rika Draenert

    Citation: Journal of Translational Medicine 2016 14:2

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  16. Content type: Commentary

    In recent years the scientific literature in the field of the prostate carcinoma (PCa) pointed out on the genetic heterogeneity and mutations occurring in this tumour, while little attention was given to the c...

    Authors: Mauro Tognon and Maurizio Provenzano

    Citation: Journal of Translational Medicine 2015 13:387

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  17. Content type: Research

    HPV infections are detected in sexually naive children. This has raised the question about the role of early HPV infections in either protecting or predisposing to further HPV infections. HPV16-specific cell-m...

    Authors: Hanna-Mari Koskimaa, Anna Paaso, Marij J. P. Welters, Seija Grénman, Kari Syrjänen, Sjoerd H. van der Burg and Stina Syrjänen

    Citation: Journal of Translational Medicine 2015 13:370

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  18. Content type: Research

    Virus-like particles (VLPs) based on Newcastle disease virus (NDV) core proteins, M and NP, and containing two chimera proteins, F/F and H/G, composed of the respiratory syncytial virus (RSV) fusion protein (F...

    Authors: Lori McGinnes Cullen, Jorge C. G. Blanco and Trudy G. Morrison

    Citation: Journal of Translational Medicine 2015 13:350

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  19. Content type: Research

    Deep invasion of the normal surrounding tissue by primary cervical cancers is a prognostic parameter for postoperative radiotherapy and relatively worse survival. However, patients with tumor-specific immunity...

    Authors: Arko Gorter, Frans Prins, Merel van Diepen, Simone Punt and Sjoerd H. van der Burg

    Citation: Journal of Translational Medicine 2015 13:295

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