Skip to main content

Immunovirology

Section edited by Luigi Buonaguro

The Immunovirology section focuses on translational research related to virology and immunity to virus-based diseases, with a particular interest in human oncogenic viruses.

Studies focused on the role of innate, as well as adaptive, immunity in the establishment, containment and/or progression of viral infections up to cancer, including vaccine and adjuvanting strategies, will be considered for publication. Classic immunology as well as more recent, less established "omics" approaches (genomics, proteomics, immunogenomics, pharmacogenomics) will also be considered.

Page 1 of 3

  1. The outbreak of Coronavirus disease of 2019 (COVID-19) caused by the Severe Acute Respiratory Syndrome coronavirus 2 (SARS-CoV-2), has posed a serious health threat. The increasing number of COVID-19 cases aro...

    Authors: Manoj Kumar and Souhaila Al Khodor

    Citation: Journal of Translational Medicine 2020 18:353

    Content type: Review

    Published on:

  2. Understanding how HLA polymorphisms may affect both susceptibility, course and severity of Covid-19 infection could help both at the clinical level to identify individuals at higher risk from the disease and a...

    Authors: Simona Pisanti, Joris Deelen, Anna Maria Gallina, Mariella Caputo, Marianna Citro, Mario Abate, Nicoletta Sacchi, Carmine Vecchione and Rosanna Martinelli

    Citation: Journal of Translational Medicine 2020 18:352

    Content type: Research

    Published on:

  3. The new Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2), which was first detected in Wuhan (China) in December of 2019 is responsible for the current global pandemic. Phylogenetic analysis reveale...

    Authors: Francesca Benedetti, Greg A. Snyder, Marta Giovanetti, Silvia Angeletti, Robert C. Gallo, Massimo Ciccozzi and Davide Zella

    Citation: Journal of Translational Medicine 2020 18:329

    Content type: Research

    Published on:

  4. Liver cancer is among the most common malignancy worldwide. Hepatocellular carcinoma (HCC), the principal histological subtype of liver cancer, is globally the third most common cause of cancer-related mortali...

    Authors: Xia Qin, Jian Zhang, Yu Lin, Xue-ming Sun, Jia-ning Zhang and Zhi-qiang Cheng

    Citation: Journal of Translational Medicine 2020 18:326

    Content type: Research

    Published on:

  5. In less than 20 years, three deadly coronaviruses, SARS-CoV, MERS-CoV and SARS-CoV-2, have emerged in human population causing hundreds to hundreds of thousands of deaths. Other coronaviruses are causing epizo...

    Authors: Laure Perrin-Cocon, Olivier Diaz, Clémence Jacquemin, Valentine Barthel, Eva Ogire, Christophe Ramière, Patrice André, Vincent Lotteau and Pierre-Olivier Vidalain

    Citation: Journal of Translational Medicine 2020 18:319

    Content type: Review

    Published on:

  6. HIV-1 Vpr encodes a 14 kDa protein that has been implicated in viral pathogenesis through modulation of several host cell functions. In addition to pro-apoptotic and cytostatic properties, Vpr can redirect cel...

    Authors: Patrick Eldin, Sophie Péron, Anastasia Galashevskaya, Nicolas Denis-Lagache, Michel Cogné, Geir Slupphaug and Laurence Briant

    Citation: Journal of Translational Medicine 2020 18:310

    Content type: Research

    Published on:

  7. In the past decade, cervical cancer has gone from being the second to the fourth most common cancer in women worldwide, but remains the second most common in developing countries. This cancer is most commonly ...

    Authors: Elham Hassen, Devendra Bansal, Randa Ghdira, Anouar Chaieb, Hedi Khairi, Abdelfattah Zakhama, Sami Remadi, Johan Hoebeke, Ali A. Sultan and Lotfi Chouchane

    Citation: Journal of Translational Medicine 2020 18:288

    Content type: Research

    Published on:

  8. The recent outbreak by SARS-CoV-2 has generated a chaos in global health and economy and claimed/infected a large number of lives. Closely resembling with SARS CoV, the present strain has manifested exceptiona...

    Authors: Amrita Banerjee, Dipannita Santra and Smarajit Maiti

    Citation: Journal of Translational Medicine 2020 18:281

    Content type: Research

    Published on:

  9. Severe acute respiratory syndrome (SARS) has been initiating pandemics since the beginning of the century. In December 2019, the world was hit again by a devastating SARS episode that has so far infected almos...

    Authors: Nitin Chitranshi, Vivek K. Gupta, Rashi Rajput, Angela Godinez, Kanishka Pushpitha, Ting Shen, Mehdi Mirzaei, Yuyi You, Devaraj Basavarajappa, Veer Gupta and Stuart L. Graham

    Citation: Journal of Translational Medicine 2020 18:278

    Content type: Research

    Published on:

  10. The genomic alterations of intrahepatic cholangiocarcinoma (ICC) in the Chinese population have not been fully revealed. Molecular profiling may provide a reference for clinical management, especially targeted...

    Authors: Longrong Wang, Hongxu Zhu, Yiming Zhao, Qi Pan, Anrong Mao, Weiping Zhu, Ning Zhang, Zhenhai Lin, Jiamin Zhou, Yilin Wang, Yongfa Zhang, Miao Wang, Yun Feng, Xigan He, Weiqi Xu and Lu Wang

    Citation: Journal of Translational Medicine 2020 18:273

    Content type: Research

    Published on:

  11. The novel coronavirus disease 2019 (COVID-19) broke out globally. Early prediction of the clinical progression was essential but still unclear. We aimed to evaluate the timeline of COVID-19 development and ana...

    Authors: Fang Wang, Mengyuan Qu, Xuan Zhou, Kai Zhao, Changxiang Lai, Qiyuan Tang, Wenjie Xian, Ruikun Chen, Xuan Li, Zhiyu Li, Qing He and Lei Liu

    Citation: Journal of Translational Medicine 2020 18:270

    Content type: Research

    Published on:

  12. With the aim of providing a dynamic evaluation of the effects of basic environmental parameters on COVID-19-related death rate, we assessed the correlation between average monthly high temperatures and populat...

    Authors: Francesca Benedetti, Maria Pachetti, Bruna Marini, Rudy Ippodrino, Robert C. Gallo, Massimo Ciccozzi and Davide Zella

    Citation: Journal of Translational Medicine 2020 18:251

    Content type: Research

    Published on:

  13. Post-transcriptional methylation modifications, including 5-methylcytosine (m5C) modification, are closely related to the tumorigenesis of cancers. However, the mRNA profile of m5C modification in hepatocellul...

    Authors: Qiyao Zhang, Qingyuan Zheng, Xiao Yu, Yuting He and Wenzhi Guo

    Citation: Journal of Translational Medicine 2020 18:245

    Content type: Research

    Published on:

  14. The persistence of HIV-1 in reservoir cells is one of the major obstacles to eradicating the virus in infected individuals receiving combination antiretroviral therapy (ART). HIV-1 persists in infected cells a...

    Authors: Chiara Orlandi, Benedetta Canovari, Federica Bozzano, Francesco Marras, Zeno Pasquini, Francesco Barchiesi, Andrea De Maria, Mauro Magnani and Anna Casabianca

    Citation: Journal of Translational Medicine 2020 18:204

    Content type: Research

    Published on:

  15. A new human coronavirus named SARS-CoV-2 was identified in several cases of acute respiratory syndrome in Wuhan, China in December 2019. On March 11 2020, WHO declared the SARS-CoV-2 infection to be a pandemic...

    Authors: Luigi Buonaguro, Maria Tagliamonte, Maria Lina Tornesello and Franco M. Buonaguro

    Citation: Journal of Translational Medicine 2020 18:185

    Content type: Commentary

    Published on:

  16. SARS-CoV-2 is a RNA coronavirus responsible for the pandemic of the Severe Acute Respiratory Syndrome (COVID-19). RNA viruses are characterized by a high mutation rate, up to a million times higher than that o...

    Authors: Maria Pachetti, Bruna Marini, Francesca Benedetti, Fabiola Giudici, Elisabetta Mauro, Paola Storici, Claudio Masciovecchio, Silvia Angeletti, Massimo Ciccozzi, Robert C. Gallo, Davide Zella and Rudy Ippodrino

    Citation: Journal of Translational Medicine 2020 18:179

    Content type: Research

    Published on:

  17. Early detection of treatment failure may improve clinical outcome and overall survival in patients with head and neck cancer after first-line treatment. Circulating cell-free HPV16 DNA (cfHPV16 DNA) was evalua...

    Authors: Tomasz W. Rutkowski, Agnieszka M. Mazurek, Mirosław Śnietura, Beata Hejduk, Maja Jędrzejewska, Barbara Bobek-Billewicz, Andrea d’Amico, Wojciech Pigłowski, Andrzej Wygoda, Krzysztof Składowski, Zofia Kołosza and Piotr Widłak

    Citation: Journal of Translational Medicine 2020 18:167

    Content type: Research

    Published on:

  18. Hepatitis B virus (HBV) remains a major cause of chronic hepatitis and hepatocellular carcinoma, and miRNAs play important roles in HBV pathogenesis. Our previous study has shown that miR-328-3p is upregulated...

    Authors: Xiaoyu Fu, Yi Ouyang, Juan Mo, Ronghua Li, Lei Fu and Shifang Peng

    Citation: Journal of Translational Medicine 2020 18:143

    Content type: Research

    Published on:

  19. The global burden of hepatitis B virus (HBV) infection in terms of morbidity and mortality is immense. Novel treatments that can induce a protective immune response are urgently needed to effectively control t...

    Authors: Yunlong Hu, Li Tang, Zhengyu Zhu, He Meng, Tingting Chen, Sheng Zhao, Zhenchao Jin, Zhulin Wang and Guangyi Jin

    Citation: Journal of Translational Medicine 2020 18:112

    Content type: Research

    Published on:

  20. Disease progression in the absence of therapy varies significantly in mono-HIV and HCV infected individuals. Virus-specific CD8+ T cells play an important role in restricting lentiviral replication and determinin...

    Authors: Si-Yao Li, Zi-Ning Zhang, Yong‑Jun Jiang, Ya‑Jing Fu and Hong Shang

    Citation: Journal of Translational Medicine 2020 18:96

    Content type: Research

    Published on:

  21. Despite the effective antiretroviral treatment (ART) of HIV-infected individuals, HIV persists in a small pool. Central memory CD4+ T cells (Tcm) make a major contribution to HIV persistence. We found that unlike...

    Authors: Cheng-Bo Song, Le-Le Zhang, Xian Wu, Ya-Jing Fu, Yong-Jun Jiang, Hong Shang and Zi-Ning Zhang

    Citation: Journal of Translational Medicine 2020 18:95

    Content type: Research

    Published on:

  22. To explore the modulatory effects and mechanism of secretory clusterin (sCLU) on cancer stem cell (CSC) properties in hepatocellular carcinoma (HCC).

    Authors: Wenjie Zheng, Min Yao, Mengna Wu, Junling Yang, Dengfu Yao and Li Wang

    Citation: Journal of Translational Medicine 2020 18:81

    Content type: Research

    Published on:

  23. Growing evidence has suggested that immune-related genes play crucial roles in the development and progression of hepatocellular carcinoma (HCC). Nevertheless, the utility of immune-related genes for evaluatin...

    Authors: Zheng Wang, Jie Zhu, Yongjuan Liu, Changhong Liu, Wenqi Wang, Fengzhe Chen and Lixian Ma

    Citation: Journal of Translational Medicine 2020 18:67

    Content type: Research

    Published on:

  24. Hepatocellular carcinoma (HCC) is the most common type of liver tumour, and is closely related to liver cirrhosis. Previous studies have focussed on the pathogenesis of liver cirrhosis developing into HCC, but...

    Authors: Chen Hao Jiang, Xin Yuan, Jiang Fen Li, Yu Fang Xie, An Zhi Zhang, Xue Li Wang, Lan Yang, Chun Xia Liu, Wei Hua Liang, Li Juan Pang, Hong Zou, Xiao Bin Cui, Xi Hua Shen, Yan Qi, Jin Fang Jiang, Wen Yi Gu…

    Citation: Journal of Translational Medicine 2020 18:40

    Content type: Research

    Published on:

  25. Neuropsychiatric manifestations are frequent in patients with systemic lupus erythematosus (SLE), yet the etiology and pathogenesis of brain damage in SLE remains unclear. Because the production of autoantibod...

    Authors: Chunshu Yang, Xiaoyu Hou, Qianhui Feng, Yingzhuo Li, Xuejiao Wang, Ling Qin and Pingting Yang

    Citation: Journal of Translational Medicine 2019 17:426

    Content type: Research

    Published on:

  26. Polymorphonuclear (PMN) elastase plays an important role in a variety of inflammatory disorders. Our aim was to analyse PMN elastase in idiopathic inflammatory myopathies (IIMs) and its association with diseas...

    Authors: Siyu Wu, Wanchan Peng, Yunli Zhang, Jingjing Guo, Jinfang Fu and Wei Wang

    Citation: Journal of Translational Medicine 2019 17:420

    Content type: Research

    Published on:

  27. Accumulated studies reported abnormal gene expression profiles of hepatocellular carcinoma (HCC) by cDNA microarray. We tried to merge cDNA microarray data from different studies to search for stably changed g...

    Authors: Yufeng Sun, Wenchao Li, Shiqi Shen, Xuejing Yang, Bing Lu, Xiaojing Zhang, Peng Lu, Yi Shen and Juling Ji

    Citation: Journal of Translational Medicine 2019 17:390

    Content type: Research

    Published on:

  28. An unexpected increased HCC recurrence and occurrence rate among HCV patients treated with direct acting antivirals combination has been reported. Aim of the study was the evaluation of early HCC occurrence ra...

    Authors: Luca Rinaldi, Alessandro Perrella, Maria Guarino, Massimo De Luca, Guido Piai, Nicola Coppola, Pia Clara Pafundi, Fortunato Ciardiello, Morena Fasano, Erika Martinelli, Giovanna Valente, Riccardo Nevola, Caterina Monari, Lucia Miglioresi, Barbara Guerrera, Massimiliano Berretta…

    Citation: Journal of Translational Medicine 2019 17:292

    Content type: Research

    Published on:

  29. The sequential activation of immediate early (IE), early (E) and late (L) genes is required to allow productive herpes simplex virus type 1 (HSV-1) infection. Several evidences suggest that, together with infl...

    Authors: Francesca La Rosa, Simone Agostini, Anna Bianchi, Raffaello Nemni, Federica Piancone, Ivana Marventano, Roberta Mancuso, Marina Saresella and Mario Clerici

    Citation: Journal of Translational Medicine 2019 17:286

    Content type: Research

    Published on:

  30. Current human influenza vaccines lack the adaptability to match the mutational rate of the virus and therefore require annual revisions. Because of extensive manufacturing times and the possibility that antige...

    Authors: Patrick Tjok Joe, Ioanna Christopoulou, Lien van Hoecke, Bert Schepens, Tine Ysenbaert, Carlo Heirman, Kris Thielemans, Xavier Saelens and Joeri L. Aerts

    Citation: Journal of Translational Medicine 2019 17:242

    Content type: Research

    Published on:

  31. In non-human primates (NHPs) and humans, partial protection from HIV/SIV infection or suppression of replication is achievable by Env-binding antibodies and Gag-specific CD8+ T-cells targeting protective epito...

    Authors: Melanie Schwerdtfeger, Anne-Marie Carola Andersson, Lasse Neukirch and Peter Johannes Holst

    Citation: Journal of Translational Medicine 2019 17:175

    Content type: Research

    Published on:

  32. In human immunodeficiency virus (HIV) infection, 10–15% of individuals exhibit a rapid decline in CD4+ T cells and become rapid progressors (RPs). Overall, understanding the factors affecting rapid disease pro...

    Authors: Ying Pan, Zi-Ning Zhang, Lin-Bo Yin, Ya-Jing Fu, Yong-Jun Jiang and Hong Shang

    Citation: Journal of Translational Medicine 2019 17:167

    Content type: Research

    Published on:

  33. New and emerging transfusion–transmitted infections remain a threat to the blood supply. Blood donors are currently screened for less than half of known agents, primarily by individual tests. A screening platf...

    Authors: Valeria De Giorgi, Huizhi Zhou, Harvey J. Alter and Robert D. Allison

    Citation: Journal of Translational Medicine 2019 17:156

    Content type: Research

    Published on:

  34. Previous studies have identified IFNγ as an important early barrier to oncolytic viruses including vaccinia. The existing innate and adaptive immune barriers restricting oncolytic virotherapy, however, can be ...

    Authors: Dobrin D. Draganov, Antonio F. Santidrian, Ivelina Minev, Duong Nguyen, Mehmet Okyay Kilinc, Ivan Petrov, Anna Vyalkova, Elliot Lander, Mark Berman, Boris Minev and Aladar A. Szalay

    Citation: Journal of Translational Medicine 2019 17:100

    Content type: Research

    Published on:

  35. Prostaglandin E receptor 2 (EP2) is an immune modulatory molecule that regulates the balance of immunity. Here we investigated the role of EP2 in immune dysregulation in patients with acute-on-chronic liver fa...

    Authors: Yunyun Wang, Chao Chen, Jinjin Qi, Fengtian Wu, Jun Guan, Zhi Chen and Haihong Zhu

    Citation: Journal of Translational Medicine 2019 17:93

    Content type: Research

    Published on:

  36. Infection with the hepatitis B virus (HBV) is an independent risk factor for liver cirrhosis and hepatocellular carcinoma, polymorphisms in HLA-DQB1 play an important role in HBV infections.

    Authors: Guojin Ou, Haixia Xu, Hao Yu, Xiao Liu, Liu Yang, Xin Ji, Jue Wang and Zhong Liu

    Citation: Journal of Translational Medicine 2018 16:362

    Content type: Research

    Published on:

  37. The mitochondrial DNA (mtDNA) seems to influence in a large number of diseases, including HIV infection. Moreover, there is a substantial inter-individual variability in the CD4+ recovery in HIV-infected patie...

    Authors: Luz M. Medrano, Mónica Gutiérrez-Rivas, Julià Blanco, Marcial García, María A. Jiménez-Sousa, Yolanda M. Pacheco, Marta Montero, José Antonio Iribarren, Enrique Bernal, Onofre Juan Martínez, José M. Benito, Norma Rallón and Salvador Resino

    Citation: Journal of Translational Medicine 2018 16:343

    Content type: Research

    Published on:

  38. Chikungunya virus (CHIKV), causes massive outbreaks of chikungunya infection in several regions of Asia, Africa and Central/South America. Being positive sense RNA virus, CHIKV replication within the host resu...

    Authors: Muhammad Tahir ul Qamar, Amna Bari, Muhammad Muzammal Adeel, Arooma Maryam, Usman Ali Ashfaq, Xiaoyong Du, Iqra Muneer, Hafiz Ishfaq Ahmad and Jia Wang

    Citation: Journal of Translational Medicine 2018 16:298

    Content type: Research

    Published on:

  39. Subclinical mastitis (SCM) is relatively common in lactating women and may be associated with HIV shedding in breast milk. The potential association between HIV infection and breast milk immunologic factors an...

    Authors: Roxane Schaub, Stéphanie Badiou, Johannes Viljoen, Pierre Dujols, Karine Bolloré, Philippe Van de Perre, Marie-Louise Newell, Ruth Bland, Nicolas Nagot and Edouard Tuaillon

    Citation: Journal of Translational Medicine 2018 16:296

    Content type: Research

    Published on:

  40. A novel prediction algorithm is needed for the identification of effective tumor associated mutated neoantigens. Only those with no homology to self wild type antigens are true predicted neoantigens (TPNAs) an...

    Authors: Annacarmen Petrizzo, Maria Tagliamonte, Angela Mauriello, Valerio Costa, Marianna Aprile, Roberta Esposito, Andrea Caporale, Antonio Luciano, Claudio Arra, Maria Lina Tornesello, Franco M. Buonaguro and Luigi Buonaguro

    Citation: Journal of Translational Medicine 2018 16:286

    Content type: Research

    Published on:

  41. Maraviroc-containing combined antiretroviral therapy (MVC-cART) improved the response to the hepatitis B virus (HBV) vaccine in HIV-infected subjects younger than 50 years old. We aimed here to explore the eff...

    Authors: Inés Herrero-Fernández, Isaac Rosado-Sánchez, Miguel Genebat, Laura Tarancón-Díez, María Mar Rodríguez-Méndez, María Mar Pozo-Balado, Carmen Lozano, Ezequiel Ruiz-Mateos, Manuel Leal and Yolanda M. Pacheco

    Citation: Journal of Translational Medicine 2018 16:238

    Content type: Research

    Published on:

  42. Mass cytometry, or CyTOF (Cytometry by Time-of-Flight), permits the simultaneous detection of over 40 phenotypic and functional immune markers in individual cells without the issues of spectral overlap seen in...

    Authors: Christine M. D. Lingblom, Sangeeta Kowli, Nithya Swaminathan, Holden T. Maecker and Stacie L. Lambert

    Citation: Journal of Translational Medicine 2018 16:153

    Content type: Research

    Published on:

  43. The etiopathology of multiple sclerosis (MS) is believed to include genetic and environmental factors. Human leukocyte antigen (HLA) alleles, in particular,  are associated with disease susceptibility, whereas...

    Authors: Simone Agostini, Roberta Mancuso, Franca R. Guerini, Sandra D’Alfonso, Cristina Agliardi, Ambra Hernis, Milena Zanzottera, Nadia Barizzone, Maurizio A. Leone, Domenico Caputo, Marco Rovaris and Mario Clerici

    Citation: Journal of Translational Medicine 2018 16:80

    Content type: Research

    Published on:

  44. NRTIs-sparing regimens exert favourable profiles on T-cell homeostasis associated parameters. Our aim was to analyze the effect of NRTIs sparing regimen (NRTI-sparing-cART) vs NRTIs-containing regimen (NRTI-cA...

    Authors: A. Gonzalez-Serna, S. Ferrando-Martinez, L. Tarancon-Diez, R. S. De Pablo-Bernal, B. Dominguez-Molina, J. L. Jiménez, M. Á. Muñoz-Fernández, M. Leal and E. Ruiz-Mateos

    Citation: Journal of Translational Medicine 2017 15:259

    Content type: Research

    Published on:

  45. Anemia is frequent during HIV infection and is predictive of mortality. Although cART has demonstrated to reduce its prevalence, several patients still experience unresolved anemia. We aimed to characterize ir...

    Authors: Eugenia Quiros-Roldan, Francesco Castelli, Paola Lanza, Chiara Pezzoli, Marika Vezzoli, Giorgio Biasiotto and Isabella Zanella

    Citation: Journal of Translational Medicine 2017 15:256

    Content type: Research

    Published on:

  46. There is limited information on innate immunity, especially natural killer (NK) cell function, in different chronic hepatitis B (CHB) stages. Therefore, we examined whether the clinical staging strategy accura...

    Authors: Xiaoyan Li, Liang Zhou, Lin Gu, Yurong Gu, Lubiao Chen, Yifan Lian and Yuehua Huang

    Citation: Journal of Translational Medicine 2017 15:220

    Content type: Research

    Published on:

  47. A major obstacle for the development of HIV vaccines is the virus’ worldwide sequence diversity. Nevertheless, the presence of T cell epitopes within conserved regions of the virus’ structural Gag protein and ...

    Authors: Anne-Marie Carola Andersson and Peter Johannes Holst

    Citation: Journal of Translational Medicine 2016 14:343

    Content type: Research

    Published on:

  48. The new microcapillary and fluorescence-based EC IVD-qualified Muse™ Auto CD4/CD4% single-platform assay (EMD Millipore Corporation, Merck Life Sciences, KGaA, Darmstadt, Germany) for CD4 T cell numeration in ...

    Authors: Christian Diamant Mossoro-Kpinde, André Kouabosso, Ralph-Sydney Mboumba Bouassa, Jean De Dieu Longo, Edouard Kokanzo, Rosine Féissona, Gérard Grésenguet and Laurent Bélec

    Citation: Journal of Translational Medicine 2016 14:326

    Content type: Research

    Published on:

Annual Journal Metrics