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Immunovirology

Section edited by Luigi Buonaguro

The Immunovirology section focuses on translational research related to virology and immunity to virus-based diseases, with a particular interest in human oncogenic viruses.

Studies focused on the role of innate, as well as adaptive, immunity in the establishment, containment and/or progression of viral infections up to cancer, including vaccine and adjuvanting strategies, will be considered for publication. Classic immunology as well as more recent, less established "omics" approaches (genomics, proteomics, immunogenomics, pharmacogenomics) will also be considered.

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  1. Hepatitis B virus (HBV) remains a major cause of chronic hepatitis and hepatocellular carcinoma, and miRNAs play important roles in HBV pathogenesis. Our previous study has shown that miR-328-3p is upregulated...

    Authors: Xiaoyu Fu, Yi Ouyang, Juan Mo, Ronghua Li, Lei Fu and Shifang Peng

    Citation: Journal of Translational Medicine 2020 18:143

    Content type: Research

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  2. The global burden of hepatitis B virus (HBV) infection in terms of morbidity and mortality is immense. Novel treatments that can induce a protective immune response are urgently needed to effectively control t...

    Authors: Yunlong Hu, Li Tang, Zhengyu Zhu, He Meng, Tingting Chen, Sheng Zhao, Zhenchao Jin, Zhulin Wang and Guangyi Jin

    Citation: Journal of Translational Medicine 2020 18:112

    Content type: Research

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  3. Disease progression in the absence of therapy varies significantly in mono-HIV and HCV infected individuals. Virus-specific CD8+ T cells play an important role in restricting lentiviral replication and determinin...

    Authors: Si-Yao Li, Zi-Ning Zhang, Yong‑Jun Jiang, Ya‑Jing Fu and Hong Shang

    Citation: Journal of Translational Medicine 2020 18:96

    Content type: Research

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  4. Despite the effective antiretroviral treatment (ART) of HIV-infected individuals, HIV persists in a small pool. Central memory CD4+ T cells (Tcm) make a major contribution to HIV persistence. We found that unlike...

    Authors: Cheng-Bo Song, Le-Le Zhang, Xian Wu, Ya-Jing Fu, Yong-Jun Jiang, Hong Shang and Zi-Ning Zhang

    Citation: Journal of Translational Medicine 2020 18:95

    Content type: Research

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  5. To explore the modulatory effects and mechanism of secretory clusterin (sCLU) on cancer stem cell (CSC) properties in hepatocellular carcinoma (HCC).

    Authors: Wenjie Zheng, Min Yao, Mengna Wu, Junling Yang, Dengfu Yao and Li Wang

    Citation: Journal of Translational Medicine 2020 18:81

    Content type: Research

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  6. Growing evidence has suggested that immune-related genes play crucial roles in the development and progression of hepatocellular carcinoma (HCC). Nevertheless, the utility of immune-related genes for evaluatin...

    Authors: Zheng Wang, Jie Zhu, Yongjuan Liu, Changhong Liu, Wenqi Wang, Fengzhe Chen and Lixian Ma

    Citation: Journal of Translational Medicine 2020 18:67

    Content type: Research

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  7. Hepatocellular carcinoma (HCC) is the most common type of liver tumour, and is closely related to liver cirrhosis. Previous studies have focussed on the pathogenesis of liver cirrhosis developing into HCC, but...

    Authors: Chen Hao Jiang, Xin Yuan, Jiang Fen Li, Yu Fang Xie, An Zhi Zhang, Xue Li Wang, Lan Yang, Chun Xia Liu, Wei Hua Liang, Li Juan Pang, Hong Zou, Xiao Bin Cui, Xi Hua Shen, Yan Qi, Jin Fang Jiang, Wen Yi Gu…

    Citation: Journal of Translational Medicine 2020 18:40

    Content type: Research

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  8. Neuropsychiatric manifestations are frequent in patients with systemic lupus erythematosus (SLE), yet the etiology and pathogenesis of brain damage in SLE remains unclear. Because the production of autoantibod...

    Authors: Chunshu Yang, Xiaoyu Hou, Qianhui Feng, Yingzhuo Li, Xuejiao Wang, Ling Qin and Pingting Yang

    Citation: Journal of Translational Medicine 2019 17:426

    Content type: Research

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  9. Polymorphonuclear (PMN) elastase plays an important role in a variety of inflammatory disorders. Our aim was to analyse PMN elastase in idiopathic inflammatory myopathies (IIMs) and its association with diseas...

    Authors: Siyu Wu, Wanchan Peng, Yunli Zhang, Jingjing Guo, Jinfang Fu and Wei Wang

    Citation: Journal of Translational Medicine 2019 17:420

    Content type: Research

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  10. Accumulated studies reported abnormal gene expression profiles of hepatocellular carcinoma (HCC) by cDNA microarray. We tried to merge cDNA microarray data from different studies to search for stably changed g...

    Authors: Yufeng Sun, Wenchao Li, Shiqi Shen, Xuejing Yang, Bing Lu, Xiaojing Zhang, Peng Lu, Yi Shen and Juling Ji

    Citation: Journal of Translational Medicine 2019 17:390

    Content type: Research

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  11. An unexpected increased HCC recurrence and occurrence rate among HCV patients treated with direct acting antivirals combination has been reported. Aim of the study was the evaluation of early HCC occurrence ra...

    Authors: Luca Rinaldi, Alessandro Perrella, Maria Guarino, Massimo De Luca, Guido Piai, Nicola Coppola, Pia Clara Pafundi, Fortunato Ciardiello, Morena Fasano, Erika Martinelli, Giovanna Valente, Riccardo Nevola, Caterina Monari, Lucia Miglioresi, Barbara Guerrera, Massimiliano Berretta…

    Citation: Journal of Translational Medicine 2019 17:292

    Content type: Research

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  12. The sequential activation of immediate early (IE), early (E) and late (L) genes is required to allow productive herpes simplex virus type 1 (HSV-1) infection. Several evidences suggest that, together with infl...

    Authors: Francesca La Rosa, Simone Agostini, Anna Bianchi, Raffaello Nemni, Federica Piancone, Ivana Marventano, Roberta Mancuso, Marina Saresella and Mario Clerici

    Citation: Journal of Translational Medicine 2019 17:286

    Content type: Research

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  13. Current human influenza vaccines lack the adaptability to match the mutational rate of the virus and therefore require annual revisions. Because of extensive manufacturing times and the possibility that antige...

    Authors: Patrick Tjok Joe, Ioanna Christopoulou, Lien van Hoecke, Bert Schepens, Tine Ysenbaert, Carlo Heirman, Kris Thielemans, Xavier Saelens and Joeri L. Aerts

    Citation: Journal of Translational Medicine 2019 17:242

    Content type: Research

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  14. In non-human primates (NHPs) and humans, partial protection from HIV/SIV infection or suppression of replication is achievable by Env-binding antibodies and Gag-specific CD8+ T-cells targeting protective epito...

    Authors: Melanie Schwerdtfeger, Anne-Marie Carola Andersson, Lasse Neukirch and Peter Johannes Holst

    Citation: Journal of Translational Medicine 2019 17:175

    Content type: Research

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  15. In human immunodeficiency virus (HIV) infection, 10–15% of individuals exhibit a rapid decline in CD4+ T cells and become rapid progressors (RPs). Overall, understanding the factors affecting rapid disease pro...

    Authors: Ying Pan, Zi-Ning Zhang, Lin-Bo Yin, Ya-Jing Fu, Yong-Jun Jiang and Hong Shang

    Citation: Journal of Translational Medicine 2019 17:167

    Content type: Research

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  16. New and emerging transfusion–transmitted infections remain a threat to the blood supply. Blood donors are currently screened for less than half of known agents, primarily by individual tests. A screening platf...

    Authors: Valeria De Giorgi, Huizhi Zhou, Harvey J. Alter and Robert D. Allison

    Citation: Journal of Translational Medicine 2019 17:156

    Content type: Research

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  17. Previous studies have identified IFNγ as an important early barrier to oncolytic viruses including vaccinia. The existing innate and adaptive immune barriers restricting oncolytic virotherapy, however, can be ...

    Authors: Dobrin D. Draganov, Antonio F. Santidrian, Ivelina Minev, Duong Nguyen, Mehmet Okyay Kilinc, Ivan Petrov, Anna Vyalkova, Elliot Lander, Mark Berman, Boris Minev and Aladar A. Szalay

    Citation: Journal of Translational Medicine 2019 17:100

    Content type: Research

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  18. Prostaglandin E receptor 2 (EP2) is an immune modulatory molecule that regulates the balance of immunity. Here we investigated the role of EP2 in immune dysregulation in patients with acute-on-chronic liver fa...

    Authors: Yunyun Wang, Chao Chen, Jinjin Qi, Fengtian Wu, Jun Guan, Zhi Chen and Haihong Zhu

    Citation: Journal of Translational Medicine 2019 17:93

    Content type: Research

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  19. Infection with the hepatitis B virus (HBV) is an independent risk factor for liver cirrhosis and hepatocellular carcinoma, polymorphisms in HLA-DQB1 play an important role in HBV infections.

    Authors: Guojin Ou, Haixia Xu, Hao Yu, Xiao Liu, Liu Yang, Xin Ji, Jue Wang and Zhong Liu

    Citation: Journal of Translational Medicine 2018 16:362

    Content type: Research

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  20. The mitochondrial DNA (mtDNA) seems to influence in a large number of diseases, including HIV infection. Moreover, there is a substantial inter-individual variability in the CD4+ recovery in HIV-infected patie...

    Authors: Luz M. Medrano, Mónica Gutiérrez-Rivas, Julià Blanco, Marcial García, María A. Jiménez-Sousa, Yolanda M. Pacheco, Marta Montero, José Antonio Iribarren, Enrique Bernal, Onofre Juan Martínez, José M. Benito, Norma Rallón and Salvador Resino

    Citation: Journal of Translational Medicine 2018 16:343

    Content type: Research

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  21. Chikungunya virus (CHIKV), causes massive outbreaks of chikungunya infection in several regions of Asia, Africa and Central/South America. Being positive sense RNA virus, CHIKV replication within the host resu...

    Authors: Muhammad Tahir ul Qamar, Amna Bari, Muhammad Muzammal Adeel, Arooma Maryam, Usman Ali Ashfaq, Xiaoyong Du, Iqra Muneer, Hafiz Ishfaq Ahmad and Jia Wang

    Citation: Journal of Translational Medicine 2018 16:298

    Content type: Research

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  22. Subclinical mastitis (SCM) is relatively common in lactating women and may be associated with HIV shedding in breast milk. The potential association between HIV infection and breast milk immunologic factors an...

    Authors: Roxane Schaub, Stéphanie Badiou, Johannes Viljoen, Pierre Dujols, Karine Bolloré, Philippe Van de Perre, Marie-Louise Newell, Ruth Bland, Nicolas Nagot and Edouard Tuaillon

    Citation: Journal of Translational Medicine 2018 16:296

    Content type: Research

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  23. A novel prediction algorithm is needed for the identification of effective tumor associated mutated neoantigens. Only those with no homology to self wild type antigens are true predicted neoantigens (TPNAs) an...

    Authors: Annacarmen Petrizzo, Maria Tagliamonte, Angela Mauriello, Valerio Costa, Marianna Aprile, Roberta Esposito, Andrea Caporale, Antonio Luciano, Claudio Arra, Maria Lina Tornesello, Franco M. Buonaguro and Luigi Buonaguro

    Citation: Journal of Translational Medicine 2018 16:286

    Content type: Research

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  24. Maraviroc-containing combined antiretroviral therapy (MVC-cART) improved the response to the hepatitis B virus (HBV) vaccine in HIV-infected subjects younger than 50 years old. We aimed here to explore the eff...

    Authors: Inés Herrero-Fernández, Isaac Rosado-Sánchez, Miguel Genebat, Laura Tarancón-Díez, María Mar Rodríguez-Méndez, María Mar Pozo-Balado, Carmen Lozano, Ezequiel Ruiz-Mateos, Manuel Leal and Yolanda M. Pacheco

    Citation: Journal of Translational Medicine 2018 16:238

    Content type: Research

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  25. Mass cytometry, or CyTOF (Cytometry by Time-of-Flight), permits the simultaneous detection of over 40 phenotypic and functional immune markers in individual cells without the issues of spectral overlap seen in...

    Authors: Christine M. D. Lingblom, Sangeeta Kowli, Nithya Swaminathan, Holden T. Maecker and Stacie L. Lambert

    Citation: Journal of Translational Medicine 2018 16:153

    Content type: Research

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  26. The etiopathology of multiple sclerosis (MS) is believed to include genetic and environmental factors. Human leukocyte antigen (HLA) alleles, in particular,  are associated with disease susceptibility, whereas...

    Authors: Simone Agostini, Roberta Mancuso, Franca R. Guerini, Sandra D’Alfonso, Cristina Agliardi, Ambra Hernis, Milena Zanzottera, Nadia Barizzone, Maurizio A. Leone, Domenico Caputo, Marco Rovaris and Mario Clerici

    Citation: Journal of Translational Medicine 2018 16:80

    Content type: Research

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  27. NRTIs-sparing regimens exert favourable profiles on T-cell homeostasis associated parameters. Our aim was to analyze the effect of NRTIs sparing regimen (NRTI-sparing-cART) vs NRTIs-containing regimen (NRTI-cA...

    Authors: A. Gonzalez-Serna, S. Ferrando-Martinez, L. Tarancon-Diez, R. S. De Pablo-Bernal, B. Dominguez-Molina, J. L. Jiménez, M. Á. Muñoz-Fernández, M. Leal and E. Ruiz-Mateos

    Citation: Journal of Translational Medicine 2017 15:259

    Content type: Research

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  28. Anemia is frequent during HIV infection and is predictive of mortality. Although cART has demonstrated to reduce its prevalence, several patients still experience unresolved anemia. We aimed to characterize ir...

    Authors: Eugenia Quiros-Roldan, Francesco Castelli, Paola Lanza, Chiara Pezzoli, Marika Vezzoli, Giorgio Biasiotto and Isabella Zanella

    Citation: Journal of Translational Medicine 2017 15:256

    Content type: Research

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  29. There is limited information on innate immunity, especially natural killer (NK) cell function, in different chronic hepatitis B (CHB) stages. Therefore, we examined whether the clinical staging strategy accura...

    Authors: Xiaoyan Li, Liang Zhou, Lin Gu, Yurong Gu, Lubiao Chen, Yifan Lian and Yuehua Huang

    Citation: Journal of Translational Medicine 2017 15:220

    Content type: Research

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  30. A major obstacle for the development of HIV vaccines is the virus’ worldwide sequence diversity. Nevertheless, the presence of T cell epitopes within conserved regions of the virus’ structural Gag protein and ...

    Authors: Anne-Marie Carola Andersson and Peter Johannes Holst

    Citation: Journal of Translational Medicine 2016 14:343

    Content type: Research

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  31. The new microcapillary and fluorescence-based EC IVD-qualified Muse™ Auto CD4/CD4% single-platform assay (EMD Millipore Corporation, Merck Life Sciences, KGaA, Darmstadt, Germany) for CD4 T cell numeration in ...

    Authors: Christian Diamant Mossoro-Kpinde, André Kouabosso, Ralph-Sydney Mboumba Bouassa, Jean De Dieu Longo, Edouard Kokanzo, Rosine Féissona, Gérard Grésenguet and Laurent Bélec

    Citation: Journal of Translational Medicine 2016 14:326

    Content type: Research

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  32. Ebola virus (EBOV) is a Category A pathogen that is a member of Filoviridae family that causes hemorrhagic fever in humans and non-human primates. Unpredictable and devastating outbreaks of disease have recently ...

    Authors: Alfonso Rosamilia, Sarah Jacca, Giulia Tebaldi, Silvia Tiberti, Valentina Franceschi, Francesca Macchi, Sandro Cavirani, Gary Kobinger, Donald P. Knowles and Gaetano Donofrio

    Citation: Journal of Translational Medicine 2016 14:325

    Content type: Research

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  33. Many investigators detected the simian polyomavirus SV40 footprints in human brain tumors and neurologic diseases and recently it has been indicated that SV40 seems to be associated with multiple sclerosis (MS...

    Authors: Roberta Rizzo, Silvia Pietrobon, Elisa Mazzoni, Daria Bortolotti, Fernanda Martini, Massimiliano Castellazzi, Ilaria Casetta, Enrico Fainardi, Dario Di Luca, Enrico Granieri and Mauro Tognon

    Citation: Journal of Translational Medicine 2016 14:216

    Content type: Research

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  34. The FluoroSpot assay, an advancement of the ELISpot assay, enables simultaneous measurement of different analytes secreted at a single-cell level. This allows parallel detection of several cytokines secreted b...

    Authors: Nina Körber, Uta Behrends, Alexander Hapfelmeier, Ulrike Protzer and Tanja Bauer

    Citation: Journal of Translational Medicine 2016 14:175

    Content type: Methodology

    Published on:

  35. We previously demonstrated that the HLA class II transactivator CIITA inhibits HIV-1 replication in T cells by competing with the viral transactivator Tat for the binding to Cyclin T1 subunit of the P-TEFb com...

    Authors: Greta Forlani, Filippo Turrini, Silvia Ghezzi, Alessandra Tedeschi, Guido Poli, Roberto S. Accolla and Giovanna Tosi

    Citation: Journal of Translational Medicine 2016 14:94

    Content type: Research

    Published on:

  36. Autoimmune Addison’s disease (AAD) is caused by multiple genetic and environmental factors. Variants of genes encoding immunologically important proteins such as the HLA molecules are strongly associated with ...

    Authors: Kine Edvardsen, Alexander Hellesen, Eystein S. Husebye and Eirik Bratland

    Citation: Journal of Translational Medicine 2016 14:68

    Content type: Research

    Published on:

  37. The tumor immunosuppressive microenvironment represents a major obstacle to an effective tumor-specific cellular immune response.

    Authors: Maria Tagliamonte, Annacarmen Petrizzo, Maria Napolitano, Antonio Luciano, Domenica Rea, Antonio Barbieri, Claudio Arra, Piera Maiolino, Marialina Tornesello, Gennaro Ciliberto, Franco M. Buonaguro and Luigi Buonaguro

    Citation: Journal of Translational Medicine 2016 14:58

    Content type: Research

    Published on:

  38. Research challenges associated with understanding HIV persistence during antiretroviral therapy can be categorized as temporal, spatial and combinatorial. Temporal research challenges relate to the timing of e...

    Authors: Paul W. Denton, Ole S. Søgaard and Martin Tolstrup

    Citation: Journal of Translational Medicine 2016 14:44

    Content type: Review

    Published on:

  39. Human myeloid-derived suppressor cells (MDSC) have been described as a group of immature myeloid cells which exert immunosuppressive action by inhibiting function of T lymphocytes. While there is a huge scient...

    Authors: Eva Grützner, Renate Stirner, Lukas Arenz, Anastasia P. Athanasoulia, Kathrin Schrödl, Carola Berking, Johannes R. Bogner and Rika Draenert

    Citation: Journal of Translational Medicine 2016 14:2

    Content type: Methodology

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  40. In recent years the scientific literature in the field of the prostate carcinoma (PCa) pointed out on the genetic heterogeneity and mutations occurring in this tumour, while little attention was given to the c...

    Authors: Mauro Tognon and Maurizio Provenzano

    Citation: Journal of Translational Medicine 2015 13:387

    Content type: Commentary

    Published on:

  41. HPV infections are detected in sexually naive children. This has raised the question about the role of early HPV infections in either protecting or predisposing to further HPV infections. HPV16-specific cell-m...

    Authors: Hanna-Mari Koskimaa, Anna Paaso, Marij J. P. Welters, Seija Grénman, Kari Syrjänen, Sjoerd H. van der Burg and Stina Syrjänen

    Citation: Journal of Translational Medicine 2015 13:370

    Content type: Research

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  42. Virus-like particles (VLPs) based on Newcastle disease virus (NDV) core proteins, M and NP, and containing two chimera proteins, F/F and H/G, composed of the respiratory syncytial virus (RSV) fusion protein (F...

    Authors: Lori McGinnes Cullen, Jorge C. G. Blanco and Trudy G. Morrison

    Citation: Journal of Translational Medicine 2015 13:350

    Content type: Research

    Published on:

  43. Deep invasion of the normal surrounding tissue by primary cervical cancers is a prognostic parameter for postoperative radiotherapy and relatively worse survival. However, patients with tumor-specific immunity...

    Authors: Arko Gorter, Frans Prins, Merel van Diepen, Simone Punt and Sjoerd H. van der Burg

    Citation: Journal of Translational Medicine 2015 13:295

    Content type: Research

    Published on:

  44. Helminths infections have been suggested to worsen the outcome of HIV infection by polarizing the immune response towards Th2. The purpose of this study is to determine the activity of Th2 immune response by m...

    Authors: Andargachew Mulu, Belay Anagaw, Aschalew Gelaw, Fuso Ota, Afework Kassu and Sisay Yifru

    Citation: Journal of Translational Medicine 2015 13:236

    Content type: Research

    Published on:

  45. High levels of ex vivo CD4 T-cell death and the accumulation of highly differentiated and/or immunosenescent T cells have been associated with poor CD4 T-cell recovery in treated HIV-infected individuals. Howe...

    Authors: Marta Massanella, Elisabet Gómez-Mora, Jorge Carrillo, Marta Curriu, Dan Ouchi, Jordi Puig, Eugènia Negredo, Cecilia Cabrera, Bonaventura Clotet and Julià Blanco

    Citation: Journal of Translational Medicine 2015 13:230

    Content type: Research

    Published on:

  46. Filovirus virus-like particles (VLP) are strong immunogens with the potential for development into a safe, non-infectious vaccine. However, the large size and filamentous structure of this virus has heretofore...

    Authors: John H Carra, Karen A O Martins, Rowena D Schokman, Camenzind G Robinson, Jesse T Steffens and Sina Bavari

    Citation: Journal of Translational Medicine 2015 13:228

    Content type: Research

    Published on:

  47. Interleukin-7 (IL-7) is a critical factor for T cell development and for maintaining and restoring homeostasis of mature T cells. Polymorphisms at α-chain of the IL-7 receptor (IL7R or CD127) gene are related ...

    Authors: María Guzmán-Fulgencio, Juan Berenguer, María A Jiménez-Sousa, Daniel Pineda-Tenor, Teresa Aldámiz-Echevarria, Pilar García-Broncano, Ana Carrero, Mónica García-Álvarez, Francisco Tejerina, Cristina Diez, Sonia Vazquez-Morón and Salvador Resino

    Citation: Journal of Translational Medicine 2015 13:206

    Content type: Research

    Published on:

  48. For more than 240 million chronic HBV carriers worldwide, effective therapeutic HBV vaccines are urgently needed. Recently, we demonstrated that autophagosomes were efficient antigens carriers and capable to c...

    Authors: Meng Xue, Fei Fan, Lei Ding, Jingyu Liu, Shu Su, Pengfei Yin, Meng Cao, Wei Zhao, Hong-ming Hu and Lixin Wang

    Citation: Journal of Translational Medicine 2014 12:361

    Content type: Research

    Published on:

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