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Translational Ophthalmology

Section edited by Geoffrey Broadhead and Levon Khachigian

This section is focused on the rapidly expanding field of translational medicine as it relates to ophthalmology and vision science, as well as the role of ophthalmology in guiding the diagnosis and care of other (non-ophthalmic) diseases. Translational Ophthalmology is a section primarily aimed at (but not limited to) studies focused on mechanisms and development of novel therapies for ophthalmic conditions, new biomarkers of ocular pathology, and the role of ophthalmology and ophthalmic findings in the diagnosis and management of systemic medical conditions.

The section aims to provide a platform for research and review articles into the expanding field of translational ophthalmology and will facilitate the publication and discussion of high-quality peer-reviewed studies in this area.

  1. Diabetic retinopathy (DR) is the foremost cause of vision loss among the global working-age population, and statins are among the most frequently prescribed drugs for lipid management in patients with DR. The ...

    Authors: Chengming Chen, Huan Zhang, Yanyan Lan, Weiming Yan, Sida Liu, Yixuan Chen, Tingke Xie, Jiayi Ning, Xiaolong Yan, Lei Shang and Jing Han
    Citation: Journal of Translational Medicine 2024 22:298
  2. Global myopia prevalence poses a substantial public health burden with vision-threatening complications, necessitating effective prevention and control strategies. Precise prediction of spherical equivalent (S...

    Authors: Jing Zhao, Yanze Yu, Yiming Li, Feng Li, Zhe Zhang, Weijun Jian, Zhi Chen, Yang Shen, Xiaoying Wang, Zhengqiang Ye, Chencui Huang and Xingtao Zhou
    Citation: Journal of Translational Medicine 2024 22:289
  3. Patients with spondyloarthritis (SpA)/HLA-B27-associated acute anterior uveitis (AAU) experience recurring acute flares, which pose significant visual and financial challenges. Despite established links betwee...

    Authors: Shuming Chen, Weidi Huang, Qiaoqian Wan, Zichun Tang, Xie Li, Fang Zeng, Shuyan Zheng, Zhuo Li and Xiao Liu
    Citation: Journal of Translational Medicine 2024 22:271
  4. In diabetic retinopathy (DR), hypoxia-inducible factor (HIF-1α) induces oxidative stress by upregulating glycolysis. This process leads to neurodegeneration, particularly photoreceptor cell damage, which furth...

    Authors: Bolin Chen, Jing Zou, Lihui Xie, Yinjun Cai, Bowen Li, Wei Tan, Jinhaohao Huang, Fangling Li and Huizhuo Xu
    Citation: Journal of Translational Medicine 2024 22:245
  5. Retinal degenerative disorders (RDDs) cause vision loss by damaging retinal neurons and photoreceptors, affecting individuals of all ages. Cell-based therapy has emerged as an effective approach for the treatm...

    Authors: Alireza Soltani Khaboushan, Negar Ebadpour, Mohammad Mehdi Johari Moghadam, Zahra Rezaee, Abdol-Mohammad Kajbafzadeh and Masoumeh Majidi Zolbin
    Citation: Journal of Translational Medicine 2024 22:227
  6. Hypertension influences the inflammatory pathological changes in the retina. The function of the inflammasomes is significant. To see if Sirtuin 1 (SIRT1) regulates angiotensin II (Ang II)-induced hypertensive...

    Authors: Jing Li, Xiaochen Wang, Jie Bai, Huangzhao Wei, Wenbo Wang and Shuai Wang
    Citation: Journal of Translational Medicine 2024 22:155
  7. Retinitis pigmentosa is the prevailing genetic cause of blindness in developed nations with no effective treatments. In the pursuit of unraveling the intricate dynamics underlying this complex disease, mechani...

    Authors: Marina Esteban-Medina, Carlos Loucera, Kinza Rian, Sheyla Velasco, Lorena Olivares-González, Regina Rodrigo, Joaquin Dopazo and Maria Peña-Chilet
    Citation: Journal of Translational Medicine 2024 22:139
  8. Unilateral high myopia (uHM), commonly observed in patients with retinal diseases or only with high myopia, is frequently associated with amblyopia with poor prognosis. This study aims to reveal the clinical a...

    Authors: Yi Jiang, Xueshan Xiao, Wenmin Sun, Yingwei Wang, Shiqiang Li, Xiaoyun Jia, Panfeng Wang, J. Fielding Hejtmancik and Qingjiong Zhang
    Citation: Journal of Translational Medicine 2024 22:75
  9. Radiomics analysis of orbital magnetic resonance imaging (MRI) shows preliminary potential for intravenous glucocorticoid (IVGC) response prediction of thyroid eye disease (TED). The current region of interest...

    Authors: Haiyang Zhang, Mengda Jiang, Hoi Chi Chan, Huijie Zhang, Jiashuo Xu, Yuting Liu, Ling Zhu, Xiaofeng Tao, Duojin Xia, Lei Zhou, Yinwei Li, Jing Sun, Xuefei Song, Huifang Zhou and Xianqun Fan
    Citation: Journal of Translational Medicine 2024 22:56
  10. Age-related macular degeneration (AMD) is an irreversible eye disease that can cause blurred vision. Regular exercise has been suggested as a therapeutic strategy for treating AMD, but how exercise improves AM...

    Authors: ChangHyuk Kwon, Wonjun Cho, Sung Woo Choi, Heeseung Oh, A. M. Abd El-Aty, Ibrahim Gecili, Ji Hoon Jeong and Tae Woo Jung
    Citation: Journal of Translational Medicine 2024 22:38
  11. Electrical activity has a crucial impact on the development and survival of neurons. Numerous recent studies have shown that noninvasive electrical stimulation (NES) has neuroprotective action in various retin...

    Authors: Jiaxian Li, Wei Zhou, Lina Liang, Yamin Li, Kai Xu, Xiaoyu Li, Ziyang Huang and Yu Jin
    Citation: Journal of Translational Medicine 2024 22:28
  12. Diabetes mellitus (DM) is a progressive disease that involves multiple organs due to increased blood glucose, and diabetic retinopathy (DR) is the main complication of DM in the eyes and causes irreversible vi...

    Authors: Yihan Wang, Yujuan Liu, Junwei Fang, Xindan Xing, Hanying Wang, Xin Shi, Xinyi Liu, Tian Niu and Kun Liu
    Citation: Journal of Translational Medicine 2024 22:2
  13. Retinal degeneration (RD) is a group of disorders on irreversible vision loss. Multiple types of stem cells were used in clinical trials for RD treatment. However, it remains unknown what kinds of stem cells a...

    Authors: Qian Liu, Jun Liu, Minmei Guo, Tzu-Cheng Sung, Ting Wang, Tao Yu, Zeyu Tian, Guoping Fan, Wencan Wu and Akon Higuchi
    Citation: Journal of Translational Medicine 2023 21:910
  14. In primary open-angle glaucoma (POAG), lowering intraocular pressure (IOP) is the only proven way of slowing vision loss. Schlemm’s canal (SC) is a hybrid vascular and lymphatic vessel that mediates aqueous hu...

    Authors: Skanda Rajasundaram, Nazlee Zebardast, Puja Mehta, Anthony P. Khawaja, Alasdair Warwick, Katherine Duchinski, Stephen Burgess, Dipender Gill, Ayellet V. Segrè and Janey Wiggs
    Citation: Journal of Translational Medicine 2023 21:847
  15. Long noncoding RNAs (lncRNAs) play a key role in the occurrence and progression of myopia. However, the function of lncRNAs in retinal ganglion cells (RGCs) in the pathogenesis of myopia is still unknown. The ...

    Authors: Xuejun Wang, Qinghong Lin, Shengtao Liu, Xiaoying Li, Xiehe Kong, Yuliang Wang, Weijung Ten, Yangyi Huang, Yanting Yang, Jing Zhao, Xiaopeng Ma and Xingtao Zhou
    Citation: Journal of Translational Medicine 2023 21:785
  16. Maintenance of internal homeostasis is a sophisticated process, during which almost all organs get involved. Liver plays a central role in metabolism and involves in endocrine, immunity, detoxification and sto...

    Authors: Junhao Wu, Caihan Duan, Yuanfan Yang, Zhe Wang, Chen Tan, Chaoqun Han and Xiaohua Hou
    Citation: Journal of Translational Medicine 2023 21:712
  17. Stem cell products are increasingly entering early stage clinical trials for treating retinal degeneration. The field is learning from experience about comparability of cells proposed for preclinical and clini...

    Authors: Bin Lu, Pablo Avalos, Soshana Svendsen, Changqing Zhang, Laura Nocito, Melissa K. Jones, Cosmo Pieplow, Joshua Saylor, Sean Ghiam, Amanda Block, Michael Fernandez, Alexander V. Ljubimov, Kent Small, David Liao, Clive N. Svendsen and Shaomei Wang
    Citation: Journal of Translational Medicine 2023 21:650
  18. Photoreceptor degeneration underpinned by oxidative stress-mediated mitochondrial dysfunction and cell death leads to progressive and irreversible vision impairment. Drug treatments that protect against photor...

    Authors: Daijin Li, Jing Xu, Jie Chang, Yujue Wang, Xiaoye Du, Hanhan Wu, Jingang Cui, Peiwei Wang, Teng Zhang and Yu Chen
    Citation: Journal of Translational Medicine 2023 21:569
  19. Ocular neovascularization is a leading cause of blindness and visual impairment. While intravitreal anti-VEGF agents can be effective, they do have several drawbacks, such as endophthalmitis and drug resistanc...

    Authors: Wen Bai, Jun-Song Ren, Min Xia, Ya Zhao, Jing-Juan Ding, Xi Chen and Qin Jiang
    Citation: Journal of Translational Medicine 2023 21:555
  20. In diabetic retinopathy, increasing evidence points to a link between the pathogenesis of retinal microangiopathy and the endothelial cell-specific factor roundabout4 (ROBO4). According to earlier research, sp...

    Authors: Liangliang Zhao, Haitao Xu, Xin Liu, Yan Cheng and Jia’nan Xie
    Citation: Journal of Translational Medicine 2023 21:455
  21. Myopia has emerged as a major public health concern globally, which is tightly associated with scleral extracellular matrix (ECM) remodeling and choroidal vasculopathy. Choroidal vasculopathy has gradually bee...

    Authors: Chang Liu, Meiyan Li, Yaming Shen, Xiaoyan Han, Ruoyan Wei, Yunzhe Wang, Shanshan Xu and Xingtao Zhou
    Citation: Journal of Translational Medicine 2023 21:412
  22. Uveitis and posterior scleritis are sight-threatening diseases with undefined pathogenesis and accurate diagnosis remains challenging.

    Authors: Lingzi Wu, Lei Zhou, Jinying An, Xianfeng Shao, Hui Zhang, Chunxi Wang, Guixia Zhao, Shuang Chen, Xuexue Cui, Xinyi Zhang, Fuhua Yang, Xiaorong Li and Xiaomin Zhang
    Citation: Journal of Translational Medicine 2023 21:388