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Translational Ophthalmology

Section edited by Geoffrey Broadhead and Levon Khachigian

This section is focused on the rapidly expanding field of translational medicine as it relates to ophthalmology and vision science, as well as the role of ophthalmology in guiding the diagnosis and care of other (non-ophthalmic) diseases. Translational Ophthalmology is a section primarily aimed at (but not limited to) studies focused on mechanisms and development of novel therapies for ophthalmic conditions, new biomarkers of ocular pathology, and the role of ophthalmology and ophthalmic findings in the diagnosis and management of systemic medical conditions.

The section aims to provide a platform for research and review articles into the expanding field of translational ophthalmology and will facilitate the publication and discussion of high-quality peer-reviewed studies in this area.

  1. Stem cell products are increasingly entering early stage clinical trials for treating retinal degeneration. The field is learning from experience about comparability of cells proposed for preclinical and clini...

    Authors: Bin Lu, Pablo Avalos, Soshana Svendsen, Changqing Zhang, Laura Nocito, Melissa K. Jones, Cosmo Pieplow, Joshua Saylor, Sean Ghiam, Amanda Block, Michael Fernandez, Alexander V. Ljubimov, Kent Small, David Liao, Clive N. Svendsen and Shaomei Wang
    Citation: Journal of Translational Medicine 2023 21:650
  2. Photoreceptor degeneration underpinned by oxidative stress-mediated mitochondrial dysfunction and cell death leads to progressive and irreversible vision impairment. Drug treatments that protect against photor...

    Authors: Daijin Li, Jing Xu, Jie Chang, Yujue Wang, Xiaoye Du, Hanhan Wu, Jingang Cui, Peiwei Wang, Teng Zhang and Yu Chen
    Citation: Journal of Translational Medicine 2023 21:569
  3. Ocular neovascularization is a leading cause of blindness and visual impairment. While intravitreal anti-VEGF agents can be effective, they do have several drawbacks, such as endophthalmitis and drug resistanc...

    Authors: Wen Bai, Jun-Song Ren, Min Xia, Ya Zhao, Jing-Juan Ding, Xi Chen and Qin Jiang
    Citation: Journal of Translational Medicine 2023 21:555
  4. In diabetic retinopathy, increasing evidence points to a link between the pathogenesis of retinal microangiopathy and the endothelial cell-specific factor roundabout4 (ROBO4). According to earlier research, sp...

    Authors: Liangliang Zhao, Haitao Xu, Xin Liu, Yan Cheng and Jia’nan Xie
    Citation: Journal of Translational Medicine 2023 21:455
  5. Myopia has emerged as a major public health concern globally, which is tightly associated with scleral extracellular matrix (ECM) remodeling and choroidal vasculopathy. Choroidal vasculopathy has gradually bee...

    Authors: Chang Liu, Meiyan Li, Yaming Shen, Xiaoyan Han, Ruoyan Wei, Yunzhe Wang, Shanshan Xu and Xingtao Zhou
    Citation: Journal of Translational Medicine 2023 21:412
  6. Uveitis and posterior scleritis are sight-threatening diseases with undefined pathogenesis and accurate diagnosis remains challenging.

    Authors: Lingzi Wu, Lei Zhou, Jinying An, Xianfeng Shao, Hui Zhang, Chunxi Wang, Guixia Zhao, Shuang Chen, Xuexue Cui, Xinyi Zhang, Fuhua Yang, Xiaorong Li and Xiaomin Zhang
    Citation: Journal of Translational Medicine 2023 21:388