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Translational Hematology

Section edited by Seah H. Lim 

The Translational hematology section of Journal of Translational Medicine will provide an international platform for presentation of high quality clinical and laboratory translational research, bridging the gap between basic research and pure clinical studies. The scope includes clinical and clinico-pathological investigations and fundamental research of translational potential in hematologic diseases. These include studies in red blood cells, white blood cells, platelets, coagulation, transfusion medicine, and cellular therapy.

We are also dedicated to education by providing a forum for reviews, commentaries, conference summaries and perspectives in new discovery of translational potentials. All submissions are subject to peer review and disclosure requirements. The rapid turn-around time for the processing, review, and publication of all manuscripts will ensure that any novel concepts or findings are current, timely, competitive, and relevant.

This section of the Journal of Translational Medicine will, therefore, be an up-to-date resource for physicians and scientists involved in translational research in hematology and related disciplines.

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  1. Multiple myeloma (MM) is a malignancy of plasma cells that remains incurable. Toll-like receptor 4 (TLR4) acts as a stress-responsive signal, protecting mitochondria during proteasome inhibitor (PI) exposure, ...

    Authors: Lina Quan, Chuiming Jia, Yiwei Guo, Yao Chen, Xinya Wang, Qiuting Xu and Yu Zhang
    Citation: Journal of Translational Medicine 2022 20:537
  2. To figure out the functions of thymic stromal lymphopoietin (TSLP) in IgG4-related disease (IgG4-RD).

    Authors: Hui Lu, Xunyao Wu, Yu Peng, Ruijie Sun, Yuxue Nie, Jingna Li, Mu Wang, Yaping Luo, Linyi Peng, Yunyun Fei, Jiaxin Zhou, Wen Zhang and Xiaofeng Zeng
    Citation: Journal of Translational Medicine 2022 20:414
  3. The BCR-ABL fusion protein is the key factor that results in the occurrence of chronic myeloid leukemia (CML). Imatinib (IM) is a targeted inhibitor of BCR-ABL to achieve complete remission. However, remission...

    Authors: Jianming Wang, Yang Liang, Yuefeng Qin, Guoyun Jiang, Yuhang Peng and Wenli Feng
    Citation: Journal of Translational Medicine 2022 20:395
  4. Acute myeloid leukemia (AML) is the most common type of acute leukemia in adults. Given the high relapse rate, more effective treatments are needed to improve clinical outcomes. We previously demonstrated that...

    Authors: Tianzhuo Zhang, Qin Fang, Ping Liu, Ping Wang, Cheng Feng and Jishi Wang
    Citation: Journal of Translational Medicine 2022 20:394
  5. Regulatory T cells (Tregs) induce immune responses and may contribute to immune escape in tumors. Accumulation of Tregs in tumors represents a critical barrier to anti-tumor immunity and immunotherapy. However...

    Authors: Xiuhua Su, Tao Sun, Meng Li, Yuan Xia, Mingying Li, Dongmei Wang, Fei Lu, Jingjing Ye and Chunyan Ji
    Citation: Journal of Translational Medicine 2022 20:378
  6. Acute Myeloid Leukemia (AML) is a hematological cancer characterized by heterogeneous hematopoietic cells. Through the use of multidimensional sequencing technologies, we previously identified a distinct myelo...

    Authors: Xue-Ping Li, Wei-Na Zhang, Jia-Ying Mao, Bai-Tian Zhao, Lu Jiang and Yan Gao
    Citation: Journal of Translational Medicine 2022 20:359
  7. Acute myeloid leukemia (AML) is the most common type of acute leukemia in adults. SEMA4D is a 150 kDa transmembrane protein that belongs to the IV class of the subfamily of semaphorin family. Previous studies ...

    Authors: Lu Liu, Lin Yang, Xiaojun Liu, Menghan Liu, Jing Liu, Xuefeng Feng, Ziyuan Nie and Jianmin Luo
    Citation: Journal of Translational Medicine 2022 20:304
  8. Autophagy plays a critical role in drug resistance in acute myeloid leukemia (AML), including the subtype with FLT3-ITD mutation. Yet how autophagy is activated and mediates resistance to FLT3 inhibitors in FL...

    Authors: Dan Xu, Yishan Chen, Ying Yang, Zhao Yin, Changfen Huang, Qiang Wang, Ling Jiang, Xuejie Jiang, Changxin Yin, Qifa Liu and Guopan Yu
    Citation: Journal of Translational Medicine 2022 20:300
  9. Despite advances in targeted agent development, effective treatment of acute myeloid leukemia (AML) remains a major clinical challenge. The B-cell lymphoma-2 (BCL-2) inhibitor exhibited promising clinical acti...

    Authors: Wenwen Wei, Shujuan Huang, Qing Ling, Shihui Mao, Yu Qian, Wenle Ye, Fenglin Li, Jiajia Pan, Xiangjie Lin, Jiansong Huang, Xin Huang, Yifan Zhai, Jie Sun and Jie Jin
    Citation: Journal of Translational Medicine 2022 20:299
  10. Aberrant epigenetic changes, like DNA methylation, histone modifications, or ubiquitination, could trigger metabolic disorders in human cancer cells. This study planed to uncover the biological roles of epigen...

    Authors: Wei Yan, Xue Shi, Huihan Wang, Aijun Liao and Wei Yang
    Citation: Journal of Translational Medicine 2022 20:296
  11. Chemoresistance serves as a huge obstacle for acute myeloid leukemia (AML) patients. To counteract the chemoresistance in AML cells, we discussed the role of maternally expressed gene 3 (MEG3) in arabinocytosi...

    Authors: Airong Wang, Yufei Chen, Luyao Shi, Mengya Li, Lingling Li, Shujuan Wang and Chong Wang
    Citation: Journal of Translational Medicine 2022 20:288
  12. Diffuse large B cell lymphoma (DLBCL) is the most common lymphoma in adults. Metabolic reprogramming in tumors is closely related to the immune microenvironment. This study aimed to explore the interactions be...

    Authors: Jing He, Ziwei Chen, Qingfeng Xue, Pingping Sun, Yuan Wang, Cindy Zhu and Wenyu Shi
    Citation: Journal of Translational Medicine 2022 20:186
  13. Myelodysplastic syndromes (MDS) are a group of heterogeneous myeloid clonal disorders characterized by ineffective haematopoiesis and immune deregulation. Emerging evidence has shown the effect of bone marrow ...

    Authors: Tong Xing, Zhong-Shi Lyu, Cai-Wen Duan, Hong-Yan Zhao, Shu-Qian Tang, Qi Wen, Yuan-Yuan Zhang, Meng Lv, Yu Wang, Lan-Ping Xu, Xiao-Hui Zhang, Xiao-Jun Huang and Yuan Kong
    Citation: Journal of Translational Medicine 2022 20:144
  14. B cell maturation antigen (BCMA), a transmembrane glycoprotein member of the tumor necrosis factor receptor superfamily 17 (TNFRSF17), highly expressed on the plasma cells of Multiple myeloma (MM) patients, as...

    Authors: Shirin Teymouri Nobari, Jafar Nouri Nojadeh and Mehdi Talebi
    Citation: Journal of Translational Medicine 2022 20:82
  15. Anemia is a significant complication of chronic inflammation and may be related to dysregulated activities among erythroblastic island (EBI) macrophages. GM-CSF was reported to be upregulated and attracted as ...

    Authors: Weijie Cao, Wenjuan Fan, Fang Wang, Yinyin Zhang, Guanghua Wu, Xiaojing Shi, Jian xiang Shi, Fengcai Gao, Meimei Yan, Rong Guo, Yingmei Li, Wei Li, Chunyan Du and Zhongxing Jiang
    Citation: Journal of Translational Medicine 2022 20:11
  16. This study aimed to recognize the hub genes associated with prognosis in follicular lymphoma (FL) treated with first-line rituximab combined with chemotherapy.

    Authors: Yu Zhou, Shasha Wang, Yunxia Tao, Haizhu Chen, Yan Qin, Xiaohui He, Shengyu Zhou, Peng Liu, Jianliang Yang, Sheng Yang, Lin Gui, Ning Lou, Zhishang Zhang, Jiarui Yao, Xiaohong Han and Yuankai Shi
    Citation: Journal of Translational Medicine 2021 19:399
  17. Painful vaso-occlusive crisis (VOC) remains the most common reason for presenting to the Emergency Department and hospitalization in patients with sickle cell disease (SCD). Although two new agents have been a...

    Authors: Tim Jang, Maria Poplawska, Emanuela Cimpeanu, George Mo, Dibyendu Dutta and Seah H. Lim
    Citation: Journal of Translational Medicine 2021 19:397
  18. Acute myeloid leukemia (AML) is the most common acute leukemia in adults, with a median age of 68 in clinical diagnosis. About 60% patients are over 60 years old. There are various treatment options for AML pa...

    Authors: Jizhang Bao, Xinhua Zhao, Jiahui Lu, Zhaoyang Hu, Minghui Hu, Xiaoxia Hu, Libing Wang, Qi Hu, Weiling Sun, Jie Wang, Hailin Chen, Hao Lu, Changgui Li, Jing Xu, Yongming Zhou and Wenwei Zhu
    Citation: Journal of Translational Medicine 2021 19:388
  19. The transcriptomic signature has not been fully elucidated in PV, as well as mRNA markers for clinical variables (thrombosis, leukemic transformation, survival, etc.). We attempted to reveal and validate cruci...

    Authors: Chao Guo, Ya-yue Gao, Qian-qian Ju, Min Wang, Chun-xia Zhang, Ming Gong and Zhen-ling Li
    Citation: Journal of Translational Medicine 2021 19:233
  20. The heterogenous cytogenetic and molecular variations were harbored by AML patients, some of which are related with AML pathogenesis and clinical outcomes. We aimed to uncover the intrinsic expression profiles...

    Authors: Chao Guo, Ya-yue Gao, Qian-qian Ju, Chun-xia Zhang, Ming Gong and Zhen-ling Li
    Citation: Journal of Translational Medicine 2021 19:228
  21. Prickle planar cell polarity protein 1 (PRICKLE1), a core component of the non-canonical Wnt/planar cell polarity (PCP) pathway, was recently reported to be upregulated and correlated with poor prognosis in so...

    Authors: Duanfeng Jiang, Yanjuan He, Qiuyu Mo, Enyi Liu, Xin Li, Lihua Huang, Qin Zhang, Fangping Chen, Yan Li and Haigang Shao
    Citation: Journal of Translational Medicine 2021 19:211
  22. Fatty acid oxidation (FAO) provides an important source of energy to promote the growth of leukemia cells. Carnitine palmitoyltransferase 1a(CPT1a), a rate-limiting enzyme of the essential step of FAO, can fac...

    Authors: Shihui Mao, Qing Ling, Jiajia Pan, Fenglin Li, Shujuan Huang, Wenle Ye, Wenwen Wei, Xiangjie Lin, Yu Qian, Yungui Wang, Xin Huang, Jiansong Huang, Jinghan Wang and Jie Jin
    Citation: Journal of Translational Medicine 2021 19:181
  23. As a common haematological malignancy, acute myeloid leukaemia (AML), particularly with extramedullary infiltration (EMI), often results in a high mortality rate and poor prognosis. Circular RNAs (circRNAs) re...

    Authors: Leilei Lin, Yu Wang, Sicheng Bian, Lili Sun, Zhibo Guo, Desheng Kong, Linlin Zhao, Dan Guo, Qi Li, Min Wu, Yuhuang Wang, Yuying Wang and Yinghua Li
    Citation: Journal of Translational Medicine 2021 19:123
  24. Epigenetic dysregulation plays important roles in leukemogenesis and the progression of acute myeloid leukemia (AML). Histone acetyltransferases (HATs) and histone deacetylases (HDACs) reciprocally regulate th...

    Authors: Xuejie Jiang, Ling Jiang, Jiaying Cheng, Fang Chen, Jinle Ni, Changxin Yin, Qiang Wang, Zhixiang Wang, Dan Fang, Zhengshan Yi, Guopan Yu, Qingxiu Zhong, Bing Z. Carter and Fanyi Meng
    Citation: Journal of Translational Medicine 2021 19:117
  25. Rho GTPase activating protein 9 (ARHGAP9) is expressed in various types of cancers and can inactivate Rho GTPases that mainly regulate cytoskeletal dynamics. However, the exact role of ARHGAP9 in acute myeloid...

    Authors: Caixia Han, Shujiao He, Ruiqi Wang, Xuefeng Gao, Hong Wang, Jingqiao Qiao, Xiangyu Meng, Yonghui Li and Li Yu
    Citation: Journal of Translational Medicine 2021 19:65
  26. IGHV mutation status is a crucial prognostic biomarker for CLL. In the present study, we investigated the transcriptomic signatures associating with IGHV mutation status and CLL prognosis.

    Authors: Chao Guo, Ya-yue Gao, Qian-qian Ju, Chun-xia Zhang, Ming Gong and Zhen-ling Li
    Citation: Journal of Translational Medicine 2021 19:42
  27. The cohesin complex plays a major role in folding the human genome into 3D structural domains. Mutations in members of the cohesin complex are known early drivers of myelodysplastic syndromes (MDS) and acute m...

    Authors: James S. Smith, Katrina M. Lappin, Stephanie G. Craig, Fabio G. Liberante, Clare M. Crean, Simon S. McDade, Alexander Thompson, Ken I. Mills and Kienan I. Savage
    Citation: Journal of Translational Medicine 2020 18:339
  28. The increased bone marrow angiogenesis is involved in the progression of multiple myeloma (MM) with the underlying mechanism poorly understood. Cancer-released exosomes could play an important role in the path...

    Authors: Liping Liu, Qinmao Ye, Langni Liu, Ji Chen Bihl, Yanfang Chen, Jing Liu and Qian Cheng
    Citation: Journal of Translational Medicine 2020 18:298
  29. NUDT15 and TPMT variants are strong genetic determinants of thiopurine-induced hematological toxicity that results in therapeutic failure in pediatric acute lymphoblastic leukemia (ALL). However, many patients wi...

    Authors: Yoomi Park, Hyery Kim, Heewon Seo, Jung Yoon Choi, Youngeun Ma, Sunmin Yun, Byung-Joo Min, Myung-Eui Seo, Keon Hee Yoo, Hyoung Jin Kang, Ho Joon Im and Ju Han Kim
    Citation: Journal of Translational Medicine 2020 18:265
  30. Overexpression of Wilms’ tumor-1 (WT1) transcription factor facilitates proliferation in acute myeloid leukemia (AML). However, whether WT1 is enriched in the leukemia-initiating cells (LICs) and leukemia stem ce...

    Authors: Bin Zhou, Xianghong Jin, Weiwei Jin, Xingzhou Huang, Yanfei Wu, Haiying Li, Weijian Zhu, Xiaoyi Qin, Haige Ye and Shenmeng Gao
    Citation: Journal of Translational Medicine 2020 18:254
  31. HDAC inhibitors (HDACi) belong to a new group of chemotherapeutics that are increasingly used in the treatment of lymphocyte-derived malignancies, but their mechanisms of action remain poorly understood. Here ...

    Authors: Tobias S. Iveland, Lars Hagen, Animesh Sharma, Mirta M. L. Sousa, Antonio Sarno, Kristian Lied Wollen, Nina Beate Liabakk and Geir Slupphaug
    Citation: Journal of Translational Medicine 2020 18:159

    The Correction to this article has been published in Journal of Translational Medicine 2021 19:243

  32. Myelodysplastic syndrome (MDS) can progress to acute myeloid leukemia (AML), and conventional chemotherapy (decitabine) does not effectively inhibit tumor cells. Enhancer of zeste homologue 2 (EZH2) and Heme o...

    Authors: Zhengchang He, Siyu Zhang, Dan Ma, Qin Fang, Liping Yang, Shaoxian Shen, Ying Chen, Lingli Ren and Jishi Wang
    Citation: Journal of Translational Medicine 2019 17:366
  33. Diffuse large B-cell lymphoma (DLBCL) is classified into germinal center-like (GCB) and non-germinal center-like (non-GCB) cell-of-origin groups, entities driven by different oncogenic pathways with different ...

    Authors: Yocanxóchitl Perfecto-Avalos, Alejandro Garcia-Gonzalez, Ana Hernandez-Reynoso, Gildardo Sánchez-Ante, Carlos Ortiz-Hidalgo, Sean-Patrick Scott, Rita Q. Fuentes-Aguilar, Ricardo Diaz-Dominguez, Grettel León-Martínez, Verónica Velasco-Vales, Mara A. Cárdenas-Escudero, José A. Hernández-Hernández, Arturo Santos, José R. Borbolla-Escoboza and Luis Villela
    Citation: Journal of Translational Medicine 2019 17:198
  34. Elevated protein expressions of CD markers such as IL2RA/CD25, CXCR4/CD184, CD34 and CD56 are associated with adverse prognosis in acute myeloid leukemia (AML). However, the prognostic value of mRNA expression...

    Authors: Wen Du, Jing He, Wei Zhou, Simin Shu, Juan Li, Wei Liu, Yun Deng, Cong Lu, Shengyan Lin, Yaokun Ma, Yanli He, Jine Zheng, Jiang Zhu, Lijuan Bai, Xiaoqing Li, Junxia Yao…
    Citation: Journal of Translational Medicine 2019 17:191
  35. Due to recurrent hypoxia-reperfusion injury induced by vaso-occlusive crises (VOC), patients with sickle cell disease (SCD) may have intestinal injury and increased permeability. These may explain the qualitat...

    Authors: Dibyendu Dutta, Barbara Methe, Salomon Amar, Alison Morris and Seah H. Lim
    Citation: Journal of Translational Medicine 2019 17:183
  36. Aberrant metabolism is a hallmark of cancer cells. Recently, ATP citrate-lyase (ACLY) expression was demonstrated as an independent predictor of clinical outcome in solid tumors. However, no systematic study was ...

    Authors: Jinghan Wang, Wenle Ye, Xiao Yan, Qi Guo, Qiuling Ma, Fang Lin, Jiansong Huang and Jie Jin
    Citation: Journal of Translational Medicine 2019 17:149
  37. Acute myeloid leukemia can develop as myoblasts infiltrate into organs and tissues anywhere other than the bone marrow, which called extramedullary infiltration (EMI), indicating a poor prognosis. Circular RNA...

    Authors: Chengfang Lv, Lili Sun, Zhibo Guo, Huibo Li, Desheng Kong, Bingqi Xu, Leilei Lin, Tianjiao Liu, Dan Guo, Jin Zhou and Yinghua Li
    Citation: Journal of Translational Medicine 2018 16:361
  38. The myeloproliferative neoplasms (MPN), polycythaemia vera (PV), essential thrombocythemia (ET) and primary myelofibrosis (PMF) are linked by a propensity to thrombosis formation and a risk of leukaemic transf...

    Authors: Graeme Greenfield, Suzanne McPherson, Ken Mills and Mary Frances McMullin
    Citation: Journal of Translational Medicine 2018 16:360
  39. Antitumor immune response of programmed cell death ligand (PD-L1) has shown clinical value not only in Hodgkin lymphoma and EBV-associated lymphomas but also in EBV-negative diffuse large B cell lymphoma (DLBC...

    Authors: Hyun Jung Kwon, Jeong Mi Yang, Jeong-Ok Lee, Jong Seok Lee and Jin Ho Paik
    Citation: Journal of Translational Medicine 2018 16:320
  40. Platycodin D (PD) is one of the major bioactive components of the roots of Platycodon grandiflorum and possesses multiple biological and pharmacological properties, such as antiviral, anti-inflammatory, and anti-...

    Authors: Qi Luo, Guangyu Wei, Xiaoqing Wu, Kai Tang, Mengdi Xu, Yulu Wu, Yun Liu, Xiaoqian Li, Zengtian Sun, Wen Ju, Kunming Qi, Chong Chen, Zhiling Yan, Hai Cheng, Feng Zhu, Zhenyu Li…
    Citation: Journal of Translational Medicine 2018 16:311
  41. In acute lymphoblastic leukemia (ALL), high ABCB1 gene expression has been associated with treatment resistance, which affects patient prognosis. Many preclinical reports and retrospective population studies h...

    Authors: Christian Ramos-Peñafiel, Irma Olarte-Carrillo, Rafael Cerón-Maldonado, Etta Rozen-Fuller, Juan Julio Kassack-Ipiña, Guillermo Meléndez-Mier, Juan Collazo-Jaloma and Adolfo Martínez-Tovar
    Citation: Journal of Translational Medicine 2018 16:245
  42. Non-typhoidal Salmonella usually induces self-limiting gastroenteritis. However, in many parts of Africa, especially in individuals who are malnourished, infected with malaria, or have sickle cell disease, the...

    Authors: Seah H. Lim, Barbara A. Methé, Bettina M. Knoll, Alison Morris and Stephen K. Obaro
    Citation: Journal of Translational Medicine 2018 16:239
  43. γδ T cells are associated with the pathogenesis of coronary atherosclerotic heart disease, but the relationship between the development of acute myocardial infarction (AMI) and γδ T cells is not clear. So we a...

    Authors: Xiao-ming Chen, Tao Zhang, Dan Qiu, Jian-yi Feng, Zhen-yi Jin, Qiang Luo, Xin-yu Wang and Xiu-li Wu
    Citation: Journal of Translational Medicine 2018 16:189
  44. In chronic lymphocytic leukemia (CLL) disease onset and progression are influenced by the behavior of specific CD4+ T cell subsets, such as T regulatory cells (Tregs). Here, we focused on the phenotypic and funct...

    Authors: Serena De Matteis, Chiara Molinari, Giulia Abbati, Tania Rossi, Roberta Napolitano, Martina Ghetti, Andrea Ghelli Luserna Di Rorà, Gerardo Musuraca, Alessandro Lucchesi, Gian Matteo Rigolin, Antonio Cuneo, Daniele Calistri, Pier Paolo Fattori, Massimiliano Bonafè and Giovanni Martinelli
    Citation: Journal of Translational Medicine 2018 16:172
  45. The immunomodulatory effects of granulocyte colony-stimulating factor (G-CSF) on T cells result in a low incidence of acute graft-versus-host disease (aGVHD) in G-CSF-mobilized allogeneic peripheral blood stem...

    Authors: Li Xuan, Xiuli Wu, Dan Qiu, Li Gao, Hui Liu, Zhiping Fan, Fen Huang, Zhenyi Jin, Jing Sun, Yangqiu Li and Qifa Liu
    Citation: Journal of Translational Medicine 2018 16:144