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Translational Hematology

Section edited by Seah H. Lim 

The Translational hematology section of Journal of Translational Medicine will provide an international platform for presentation of high quality clinical and laboratory translational research, bridging the gap between basic research and pure clinical studies. The scope includes clinical and clinico-pathological investigations and fundamental research of translational potential in hematologic diseases. These include studies in red blood cells, white blood cells, platelets, coagulation, transfusion medicine, and cellular therapy.


We are also dedicated to education by providing a forum for reviews, commentaries, conference summaries and perspectives in new discovery of translational potentials. All submissions are subject to peer review and disclosure requirements. The rapid turn-around time for the processing, review, and publication of all manuscripts will ensure that any novel concepts or findings are current, timely, competitive, and relevant.


This section of the Journal of Translational Medicine will, therefore, be an up-to-date resource for physicians and scientists involved in translational research in hematology and related disciplines.

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  1. Myelodysplastic neoplasms (MDS) are myeloid neoplasms characterized by disordered differentiation of hematopoietic stem cells and a predisposition to acute myeloid leukemia (AML). The underline pathogenesis re...

    Authors: Xiangzong Zeng, Yichen Wang, Min Dai, Wei Li, Qingtian Huang, Lingsha Qin, Yuquan Li, Yanwen Yan, Xiangjun Xue, Fang Yi, Wenhao Li, Langyu He, Qifa Liu and Ling Qi
    Citation: Journal of Translational Medicine 2024 22:359
  2. LILRB3, a member of the leukocyte immunoglobulin-like receptor B (LILRB) family, has immunosuppressive functions and directly regulates cancer development, which indicates that LILRB3 is an attractive target f...

    Authors: Qingyan Cen, Jianyu Chen, Jiaxin Guo, Mu Chen, Hao Wang, Suwan Wu, Honghao Zhang, Xiaoling Xie and Yuhua Li
    Citation: Journal of Translational Medicine 2024 22:278
  3. Overexpression of T-cell immunoglobulin and mucin domain-containing protein 3 (TIM3) is related to the exhaustion of CD8+ tumor-infiltrating lymphocytes (TILs) in diffuse large B-cell lymphoma (DLBCL). However, t...

    Authors: Qiqi Zhu, Yiming Yang, Kexin Chen, Qiaoyu Zhang, Yifan Huang and Shunhai Jian
    Citation: Journal of Translational Medicine 2024 22:174
  4. Hemolysis is a cardinal feature of hemolytic uremic syndrome (HUS) and during hemolysis excess arginase 1 is released from red blood cells. Increased arginase activity leads to reduced L-arginine, as it is con...

    Authors: Niklas Friberg, Ida Arvidsson, Ashmita Tontanahal, Ann-Charlotte Kristoffersson, Magnus Gram, Bernard S. Kaplan and Diana Karpman
    Citation: Journal of Translational Medicine 2024 22:17
  5. Multiple myeloma (MM), an incurable disease owing to drug resistance, requires safe and effective therapies. Norcantharidin (NCTD), an active ingredient in traditional Chinese medicines, possesses activity aga...

    Authors: Yingcong Wang, Sanfeng Dong, Ke Hu, Li Xu, Qilin Feng, Bo Li, Guangli Wang, Gege Chen, Bibo Zhang, Xinyan Jia, Zhijian Xu, Xuejie Gao, Hui Zhang, Yongsheng Xie, Meiling Lu, Shuaikang Chang…
    Citation: Journal of Translational Medicine 2023 21:858
  6. The composition of the bone marrow immune microenvironment in patients with acute myeloid leukaemia (AML) was analysed by single-cell sequencing and the evolutionary role of different subpopulations of T cells...

    Authors: Xin Wu, Zhongguang Wu, Woding Deng, Rong Xu, Chunmei Ban, Xiaoying Sun and Qiangqiang Zhao
    Citation: Journal of Translational Medicine 2023 21:760
  7. Diffuse large B-cell lymphoma (DLBCL) is an aggressive malignancy. Neutrophil extracellular traps (NETs) are pathogen-trapping structures in the tumor microenvironment that affect DLBCL progression. However, t...

    Authors: Huizhong Shi, Yiming Pan, Guifen Xiang, Mingwei Wang, Yusong Huang, Liu He, Jue Wang, Qian Fang, Ling Li and Zhong Liu
    Citation: Journal of Translational Medicine 2023 21:630
  8. The tumor microenvironment (TME) is a supportive environment responsible for promoting the growth and proliferation of tumor cells. Current studies have revealed that the bone marrow mesenchymal stem cells (BM...

    Authors: Chengyun Pan, Tianzhen Hu, Ping Liu, Dan Ma, Shuyun Cao, Qin Shang, Luxin Zhang, Qingzhen Chen, Qin Fang and Jishi Wang
    Citation: Journal of Translational Medicine 2023 21:593
  9. DNA methyltransferase 3A (DNMT3A) is frequently mutated in acute myeloid leukemia (AML) with Arg882His (R882H) as the hotspot mutation. It has been reported that DNMT3A mutation plays a key role in leukemogene...

    Authors: Xuejiao Yang, Xiao Wang, Ying Yang, Zhiyang Li, Yunshuo Chen, Siqi Shang and Yueying Wang
    Citation: Journal of Translational Medicine 2023 21:481
  10. The previous studies have revealed that abnormal RNA-binding protein Musashi-2 (MSI2) expression is associated with cancer progression through post-transcriptional mechanisms, however mechanistic details of th...

    Authors: Fanfan Li, Yixiang Han, Rongrong Chen, Yinyan Jiang, Cheng Chen, Xiaofang Wang, Jifan Zhou, Qingqing Xu, Songfu Jiang, Si Zhang, Kang Yu and Shenghui Zhang
    Citation: Journal of Translational Medicine 2023 21:309
  11. Despite significant advancements in multiple myeloma (MM) therapy, the highly heterogenous treatment response hinders reliable prognosis and tailored therapeutics. Herein, we have studied the clinical utility ...

    Authors: Maria-Alexandra Papadimitriou, Konstantinos Soureas, Aristea-Maria Papanota, Panagiotis Tsiakanikas, Panagiotis G. Adamopoulos, Ioannis Ntanasis-Stathopoulos, Panagiotis Malandrakis, Maria Gavriatopoulou, Diamantis C. Sideris, Efstathios Kastritis, Margaritis Avgeris, Meletios-Athanasios Dimopoulos, Evangelos Terpos and Andreas Scorilas
    Citation: Journal of Translational Medicine 2023 21:245
  12. The intestinal barrier is a complex structure that not only regulates the influx of luminal contents into the systemic circulation but is also involved in immune, microbial, and metabolic homeostasis. Evidence...

    Authors: Elio Haroun, Prashanth Ashok Kumar, Ludovic Saba, Joseph Kassab, Krishna Ghimire, Dibyendu Dutta and Seah H. Lim
    Citation: Journal of Translational Medicine 2023 21:233
  13. Spermatogenesis associated serine rich 2 like (SPATS2L) was highly expressed in homoharringtonine (HHT) resistant acute myeloid leukemia (AML) cell lines. However, its role is little known in AML. The present ...

    Authors: Fenglin Li, Wenle Ye, Yiyi Yao, Wenwen Wei, Xiangjie Lin, Haihui Zhuang, Chenying Li, Xia Li, Qing Ling, Chao Hu, Xin Huang, Yu Qian, Shihui Mao, Jiansong Huang, Ying Lu and Jie Jin
    Citation: Journal of Translational Medicine 2023 21:115
  14. The prognosis of B-cell acute lymphoblastic leukemia (B-ALL) has improved significantly with current first-line therapy, although the recurrence of B-ALL is still a problem. Toll-like receptor 9 (TLR9) agonist...

    Authors: Ling Bai, Lei Zhou, Wei Han, Jingtao Chen, Xiaoyi Gu, Zheng Hu, Yongguang Yang, Wei Li, Xiaoying Zhang, Chao Niu, Yongchong Chen, Hui Li and Jiuwei Cui
    Citation: Journal of Translational Medicine 2023 21:108
  15. Alternative splicing (AS) of RNA is a fundamental biological process that shapes protein diversity. Many non-characteristic AS events are involved in the onset and development of acute myeloid leukemia (AML). ...

    Authors: Fang-Min Zhong, Fang-Yi Yao, Jing Liu, Mei-Yong Li, Jun-Yao Jiang, Ying Cheng, Shuai Xu, Shu-Qi Li, Nan Zhang, Bo Huang and Xiao-Zhong Wang
    Citation: Journal of Translational Medicine 2023 21:6
  16. Acute myeloid leukemia (AML) patients with normal karyotype (NK-AML) have significant variabilities in outcomes. The European Leukemia Net stratification system and some prognostic models have been used to eva...

    Authors: Yu Liu, Yufei Chen, Yajun Liu, Mengya Li, Yu Zhang, Luyao Shi, Lu Yang, Tao Li, Yafei Li, Zhongxing Jiang, Yanfang Liu, Chong Wang and Shujuan Wang
    Citation: Journal of Translational Medicine 2022 20:612
  17. Multiple myeloma (MM) is a malignancy of plasma cells that remains incurable. Toll-like receptor 4 (TLR4) acts as a stress-responsive signal, protecting mitochondria during proteasome inhibitor (PI) exposure, ...

    Authors: Chuiming Jia, Yiwei Guo, Yao Chen, Xinya Wang, Qiuting Xu, Yu Zhang and Lina Quan
    Citation: Journal of Translational Medicine 2022 20:537

    The Correction to this article has been published in Journal of Translational Medicine 2023 21:58

  18. To figure out the functions of thymic stromal lymphopoietin (TSLP) in IgG4-related disease (IgG4-RD).

    Authors: Hui Lu, Xunyao Wu, Yu Peng, Ruijie Sun, Yuxue Nie, Jingna Li, Mu Wang, Yaping Luo, Linyi Peng, Yunyun Fei, Jiaxin Zhou, Wen Zhang and Xiaofeng Zeng
    Citation: Journal of Translational Medicine 2022 20:414
  19. The BCR-ABL fusion protein is the key factor that results in the occurrence of chronic myeloid leukemia (CML). Imatinib (IM) is a targeted inhibitor of BCR-ABL to achieve complete remission. However, remission...

    Authors: Jianming Wang, Yang Liang, Yuefeng Qin, Guoyun Jiang, Yuhang Peng and Wenli Feng
    Citation: Journal of Translational Medicine 2022 20:395
  20. Acute myeloid leukemia (AML) is the most common type of acute leukemia in adults. Given the high relapse rate, more effective treatments are needed to improve clinical outcomes. We previously demonstrated that...

    Authors: Tianzhuo Zhang, Qin Fang, Ping Liu, Ping Wang, Cheng Feng and Jishi Wang
    Citation: Journal of Translational Medicine 2022 20:394
  21. Regulatory T cells (Tregs) induce immune responses and may contribute to immune escape in tumors. Accumulation of Tregs in tumors represents a critical barrier to anti-tumor immunity and immunotherapy. However...

    Authors: Xiuhua Su, Tao Sun, Meng Li, Yuan Xia, Mingying Li, Dongmei Wang, Fei Lu, Jingjing Ye and Chunyan Ji
    Citation: Journal of Translational Medicine 2022 20:378
  22. Acute Myeloid Leukemia (AML) is a hematological cancer characterized by heterogeneous hematopoietic cells. Through the use of multidimensional sequencing technologies, we previously identified a distinct myelo...

    Authors: Xue-Ping Li, Wei-Na Zhang, Jia-Ying Mao, Bai-Tian Zhao, Lu Jiang and Yan Gao
    Citation: Journal of Translational Medicine 2022 20:359
  23. Acute myeloid leukemia (AML) is the most common type of acute leukemia in adults. SEMA4D is a 150 kDa transmembrane protein that belongs to the IV class of the subfamily of semaphorin family. Previous studies ...

    Authors: Lu Liu, Lin Yang, Xiaojun Liu, Menghan Liu, Jing Liu, Xuefeng Feng, Ziyuan Nie and Jianmin Luo
    Citation: Journal of Translational Medicine 2022 20:304
  24. Autophagy plays a critical role in drug resistance in acute myeloid leukemia (AML), including the subtype with FLT3-ITD mutation. Yet how autophagy is activated and mediates resistance to FLT3 inhibitors in FL...

    Authors: Dan Xu, Yishan Chen, Ying Yang, Zhao Yin, Changfen Huang, Qiang Wang, Ling Jiang, Xuejie Jiang, Changxin Yin, Qifa Liu and Guopan Yu
    Citation: Journal of Translational Medicine 2022 20:300
  25. Despite advances in targeted agent development, effective treatment of acute myeloid leukemia (AML) remains a major clinical challenge. The B-cell lymphoma-2 (BCL-2) inhibitor exhibited promising clinical acti...

    Authors: Wenwen Wei, Shujuan Huang, Qing Ling, Shihui Mao, Yu Qian, Wenle Ye, Fenglin Li, Jiajia Pan, Xiangjie Lin, Jiansong Huang, Xin Huang, Yifan Zhai, Jie Sun and Jie Jin
    Citation: Journal of Translational Medicine 2022 20:299
  26. Aberrant epigenetic changes, like DNA methylation, histone modifications, or ubiquitination, could trigger metabolic disorders in human cancer cells. This study planed to uncover the biological roles of epigen...

    Authors: Wei Yan, Xue Shi, Huihan Wang, Aijun Liao and Wei Yang
    Citation: Journal of Translational Medicine 2022 20:296
  27. Chemoresistance serves as a huge obstacle for acute myeloid leukemia (AML) patients. To counteract the chemoresistance in AML cells, we discussed the role of maternally expressed gene 3 (MEG3) in arabinocytosi...

    Authors: Airong Wang, Yufei Chen, Luyao Shi, Mengya Li, Lingling Li, Shujuan Wang and Chong Wang
    Citation: Journal of Translational Medicine 2022 20:288
  28. Diffuse large B cell lymphoma (DLBCL) is the most common lymphoma in adults. Metabolic reprogramming in tumors is closely related to the immune microenvironment. This study aimed to explore the interactions be...

    Authors: Jing He, Ziwei Chen, Qingfeng Xue, Pingping Sun, Yuan Wang, Cindy Zhu and Wenyu Shi
    Citation: Journal of Translational Medicine 2022 20:186
  29. Myelodysplastic syndromes (MDS) are a group of heterogeneous myeloid clonal disorders characterized by ineffective haematopoiesis and immune deregulation. Emerging evidence has shown the effect of bone marrow ...

    Authors: Tong Xing, Zhong-Shi Lyu, Cai-Wen Duan, Hong-Yan Zhao, Shu-Qian Tang, Qi Wen, Yuan-Yuan Zhang, Meng Lv, Yu Wang, Lan-Ping Xu, Xiao-Hui Zhang, Xiao-Jun Huang and Yuan Kong
    Citation: Journal of Translational Medicine 2022 20:144
  30. B cell maturation antigen (BCMA), a transmembrane glycoprotein member of the tumor necrosis factor receptor superfamily 17 (TNFRSF17), highly expressed on the plasma cells of Multiple myeloma (MM) patients, as...

    Authors: Shirin Teymouri Nobari, Jafar Nouri Nojadeh and Mehdi Talebi
    Citation: Journal of Translational Medicine 2022 20:82
  31. Anemia is a significant complication of chronic inflammation and may be related to dysregulated activities among erythroblastic island (EBI) macrophages. GM-CSF was reported to be upregulated and attracted as ...

    Authors: Weijie Cao, Wenjuan Fan, Fang Wang, Yinyin Zhang, Guanghua Wu, Xiaojing Shi, Jian xiang Shi, Fengcai Gao, Meimei Yan, Rong Guo, Yingmei Li, Wei Li, Chunyan Du and Zhongxing Jiang
    Citation: Journal of Translational Medicine 2022 20:11
  32. This study aimed to recognize the hub genes associated with prognosis in follicular lymphoma (FL) treated with first-line rituximab combined with chemotherapy.

    Authors: Yu Zhou, Shasha Wang, Yunxia Tao, Haizhu Chen, Yan Qin, Xiaohui He, Shengyu Zhou, Peng Liu, Jianliang Yang, Sheng Yang, Lin Gui, Ning Lou, Zhishang Zhang, Jiarui Yao, Xiaohong Han and Yuankai Shi
    Citation: Journal of Translational Medicine 2021 19:399
  33. Painful vaso-occlusive crisis (VOC) remains the most common reason for presenting to the Emergency Department and hospitalization in patients with sickle cell disease (SCD). Although two new agents have been a...

    Authors: Tim Jang, Maria Poplawska, Emanuela Cimpeanu, George Mo, Dibyendu Dutta and Seah H. Lim
    Citation: Journal of Translational Medicine 2021 19:397
  34. Acute myeloid leukemia (AML) is the most common acute leukemia in adults, with a median age of 68 in clinical diagnosis. About 60% patients are over 60 years old. There are various treatment options for AML pa...

    Authors: Jizhang Bao, Xinhua Zhao, Jiahui Lu, Zhaoyang Hu, Minghui Hu, Xiaoxia Hu, Libing Wang, Qi Hu, Weiling Sun, Jie Wang, Hailin Chen, Hao Lu, Changgui Li, Jing Xu, Yongming Zhou and Wenwei Zhu
    Citation: Journal of Translational Medicine 2021 19:388
  35. The transcriptomic signature has not been fully elucidated in PV, as well as mRNA markers for clinical variables (thrombosis, leukemic transformation, survival, etc.). We attempted to reveal and validate cruci...

    Authors: Chao Guo, Ya-yue Gao, Qian-qian Ju, Min Wang, Chun-xia Zhang, Ming Gong and Zhen-ling Li
    Citation: Journal of Translational Medicine 2021 19:233
  36. The heterogenous cytogenetic and molecular variations were harbored by AML patients, some of which are related with AML pathogenesis and clinical outcomes. We aimed to uncover the intrinsic expression profiles...

    Authors: Chao Guo, Ya-yue Gao, Qian-qian Ju, Chun-xia Zhang, Ming Gong and Zhen-ling Li
    Citation: Journal of Translational Medicine 2021 19:228
  37. Prickle planar cell polarity protein 1 (PRICKLE1), a core component of the non-canonical Wnt/planar cell polarity (PCP) pathway, was recently reported to be upregulated and correlated with poor prognosis in so...

    Authors: Duanfeng Jiang, Yanjuan He, Qiuyu Mo, Enyi Liu, Xin Li, Lihua Huang, Qin Zhang, Fangping Chen, Yan Li and Haigang Shao
    Citation: Journal of Translational Medicine 2021 19:211
  38. Fatty acid oxidation (FAO) provides an important source of energy to promote the growth of leukemia cells. Carnitine palmitoyltransferase 1a(CPT1a), a rate-limiting enzyme of the essential step of FAO, can fac...

    Authors: Shihui Mao, Qing Ling, Jiajia Pan, Fenglin Li, Shujuan Huang, Wenle Ye, Wenwen Wei, Xiangjie Lin, Yu Qian, Yungui Wang, Xin Huang, Jiansong Huang, Jinghan Wang and Jie Jin
    Citation: Journal of Translational Medicine 2021 19:181
  39. As a common haematological malignancy, acute myeloid leukaemia (AML), particularly with extramedullary infiltration (EMI), often results in a high mortality rate and poor prognosis. Circular RNAs (circRNAs) re...

    Authors: Leilei Lin, Yu Wang, Sicheng Bian, Lili Sun, Zhibo Guo, Desheng Kong, Linlin Zhao, Dan Guo, Qi Li, Min Wu, Yuhuang Wang, Yuying Wang and Yinghua Li
    Citation: Journal of Translational Medicine 2021 19:123
  40. Epigenetic dysregulation plays important roles in leukemogenesis and the progression of acute myeloid leukemia (AML). Histone acetyltransferases (HATs) and histone deacetylases (HDACs) reciprocally regulate th...

    Authors: Xuejie Jiang, Ling Jiang, Jiaying Cheng, Fang Chen, Jinle Ni, Changxin Yin, Qiang Wang, Zhixiang Wang, Dan Fang, Zhengshan Yi, Guopan Yu, Qingxiu Zhong, Bing Z. Carter and Fanyi Meng
    Citation: Journal of Translational Medicine 2021 19:117
  41. Rho GTPase activating protein 9 (ARHGAP9) is expressed in various types of cancers and can inactivate Rho GTPases that mainly regulate cytoskeletal dynamics. However, the exact role of ARHGAP9 in acute myeloid...

    Authors: Caixia Han, Shujiao He, Ruiqi Wang, Xuefeng Gao, Hong Wang, Jingqiao Qiao, Xiangyu Meng, Yonghui Li and Li Yu
    Citation: Journal of Translational Medicine 2021 19:65
  42. IGHV mutation status is a crucial prognostic biomarker for CLL. In the present study, we investigated the transcriptomic signatures associating with IGHV mutation status and CLL prognosis.

    Authors: Chao Guo, Ya-yue Gao, Qian-qian Ju, Chun-xia Zhang, Ming Gong and Zhen-ling Li
    Citation: Journal of Translational Medicine 2021 19:42
  43. The cohesin complex plays a major role in folding the human genome into 3D structural domains. Mutations in members of the cohesin complex are known early drivers of myelodysplastic syndromes (MDS) and acute m...

    Authors: James S. Smith, Katrina M. Lappin, Stephanie G. Craig, Fabio G. Liberante, Clare M. Crean, Simon S. McDade, Alexander Thompson, Ken I. Mills and Kienan I. Savage
    Citation: Journal of Translational Medicine 2020 18:339
  44. The increased bone marrow angiogenesis is involved in the progression of multiple myeloma (MM) with the underlying mechanism poorly understood. Cancer-released exosomes could play an important role in the path...

    Authors: Liping Liu, Qinmao Ye, Langni Liu, Ji Chen Bihl, Yanfang Chen, Jing Liu and Qian Cheng
    Citation: Journal of Translational Medicine 2020 18:298