Skip to main content


Translational hematology

Section edited by Seah H. Lim 

The Translational hematology section of Journal of Translational Medicine will provide an international platform for presentation of high quality clinical and laboratory translational research, bridging the gap between basic research and pure clinical studies. The scope includes clinical and clinico-pathological investigations and fundamental research of translational potential in hematologic diseases. These include studies in red blood cells, white blood cells, platelets, coagulation, transfusion medicine, and cellular therapy.

We are also dedicated to education by providing a forum for reviews, commentaries, conference summaries and perspectives in new discovery of translational potentials. All submissions are subject to peer review and disclosure requirements. The rapid turn-around time for the processing, review, and publication of all manuscripts will ensure that any novel concepts or findings are current, timely, competitive, and relevant.

This section of the Journal of Translational Medicine will, therefore, be an up-to-date resource for physicians and scientists involved in translational research in hematology and related disciplines.

  1. Content type: Research

    Diffuse large B-cell lymphoma (DLBCL) is classified into germinal center-like (GCB) and non-germinal center-like (non-GCB) cell-of-origin groups, entities driven by different oncogenic pathways with different ...

    Authors: Yocanxóchitl Perfecto-Avalos, Alejandro Garcia-Gonzalez, Ana Hernandez-Reynoso, Gildardo Sánchez-Ante, Carlos Ortiz-Hidalgo, Sean-Patrick Scott, Rita Q. Fuentes-Aguilar, Ricardo Diaz-Dominguez, Grettel León-Martínez, Verónica Velasco-Vales, Mara A. Cárdenas-Escudero, José A. Hernández-Hernández, Arturo Santos, José R. Borbolla-Escoboza and Luis Villela

    Citation: Journal of Translational Medicine 2019 17:198

    Published on:

  2. Content type: Research

    Elevated protein expressions of CD markers such as IL2RA/CD25, CXCR4/CD184, CD34 and CD56 are associated with adverse prognosis in acute myeloid leukemia (AML). However, the prognostic value of mRNA expression...

    Authors: Wen Du, Jing He, Wei Zhou, Simin Shu, Juan Li, Wei Liu, Yun Deng, Cong Lu, Shengyan Lin, Yaokun Ma, Yanli He, Jine Zheng, Jiang Zhu, Lijuan Bai, Xiaoqing Li, Junxia Yao…

    Citation: Journal of Translational Medicine 2019 17:191

    Published on:

  3. Content type: Research

    Due to recurrent hypoxia-reperfusion injury induced by vaso-occlusive crises (VOC), patients with sickle cell disease (SCD) may have intestinal injury and increased permeability. These may explain the qualitat...

    Authors: Dibyendu Dutta, Barbara Methe, Salomon Amar, Alison Morris and Seah H. Lim

    Citation: Journal of Translational Medicine 2019 17:183

    Published on:

  4. Content type: Research

    Aberrant metabolism is a hallmark of cancer cells. Recently, ATP citrate-lyase (ACLY) expression was demonstrated as an independent predictor of clinical outcome in solid tumors. However, no systematic study was ...

    Authors: Jinghan Wang, Wenle Ye, Xiao Yan, Qi Guo, Qiuling Ma, Fang Lin, Jiansong Huang and Jie Jin

    Citation: Journal of Translational Medicine 2019 17:149

    Published on:

  5. Content type: Research

    Acute myeloid leukemia can develop as myoblasts infiltrate into organs and tissues anywhere other than the bone marrow, which called extramedullary infiltration (EMI), indicating a poor prognosis. Circular RNA...

    Authors: Chengfang Lv, Lili Sun, Zhibo Guo, Huibo Li, Desheng Kong, Bingqi Xu, Leilei Lin, Tianjiao Liu, Dan Guo, Jin Zhou and Yinghua Li

    Citation: Journal of Translational Medicine 2018 16:361

    Published on:

  6. Content type: Review

    The myeloproliferative neoplasms (MPN), polycythaemia vera (PV), essential thrombocythemia (ET) and primary myelofibrosis (PMF) are linked by a propensity to thrombosis formation and a risk of leukaemic transf...

    Authors: Graeme Greenfield, Suzanne McPherson, Ken Mills and Mary Frances McMullin

    Citation: Journal of Translational Medicine 2018 16:360

    Published on:

  7. Content type: Research

    Antitumor immune response of programmed cell death ligand (PD-L1) has shown clinical value not only in Hodgkin lymphoma and EBV-associated lymphomas but also in EBV-negative diffuse large B cell lymphoma (DLBC...

    Authors: Hyun Jung Kwon, Jeong Mi Yang, Jeong-Ok Lee, Jong Seok Lee and Jin Ho Paik

    Citation: Journal of Translational Medicine 2018 16:320

    Published on:

  8. Content type: Research

    Platycodin D (PD) is one of the major bioactive components of the roots of Platycodon grandiflorum and possesses multiple biological and pharmacological properties, such as antiviral, anti-inflammatory, and anti-...

    Authors: Qi Luo, Guangyu Wei, Xiaoqing Wu, Kai Tang, Mengdi Xu, Yulu Wu, Yun Liu, Xiaoqian Li, Zengtian Sun, Wen Ju, Kunming Qi, Chong Chen, Zhiling Yan, Hai Cheng, Feng Zhu, Zhenyu Li…

    Citation: Journal of Translational Medicine 2018 16:311

    Published on:

  9. Content type: Research

    In acute lymphoblastic leukemia (ALL), high ABCB1 gene expression has been associated with treatment resistance, which affects patient prognosis. Many preclinical reports and retrospective population studies h...

    Authors: Christian Ramos-Peñafiel, Irma Olarte-Carrillo, Rafael Cerón-Maldonado, Etta Rozen-Fuller, Juan Julio Kassack-Ipiña, Guillermo Meléndez-Mier, Juan Collazo-Jaloma and Adolfo Martínez-Tovar

    Citation: Journal of Translational Medicine 2018 16:245

    Published on:

  10. Content type: Commentary

    Non-typhoidal Salmonella usually induces self-limiting gastroenteritis. However, in many parts of Africa, especially in individuals who are malnourished, infected with malaria, or have sickle cell disease, the...

    Authors: Seah H. Lim, Barbara A. Methé, Bettina M. Knoll, Alison Morris and Stephen K. Obaro

    Citation: Journal of Translational Medicine 2018 16:239

    Published on:

  11. Content type: Research

    γδ T cells are associated with the pathogenesis of coronary atherosclerotic heart disease, but the relationship between the development of acute myocardial infarction (AMI) and γδ T cells is not clear. So we a...

    Authors: Xiao-ming Chen, Tao Zhang, Dan Qiu, Jian-yi Feng, Zhen-yi Jin, Qiang Luo, Xin-yu Wang and Xiu-li Wu

    Citation: Journal of Translational Medicine 2018 16:189

    Published on:

  12. Content type: Research

    In chronic lymphocytic leukemia (CLL) disease onset and progression are influenced by the behavior of specific CD4+ T cell subsets, such as T regulatory cells (Tregs). Here, we focused on the phenotypic and funct...

    Authors: Serena De Matteis, Chiara Molinari, Giulia Abbati, Tania Rossi, Roberta Napolitano, Martina Ghetti, Andrea Ghelli Luserna Di Rorà, Gerardo Musuraca, Alessandro Lucchesi, Gian Matteo Rigolin, Antonio Cuneo, Daniele Calistri, Pier Paolo Fattori, Massimiliano Bonafè and Giovanni Martinelli

    Citation: Journal of Translational Medicine 2018 16:172

    Published on:

  13. Content type: Research

    The immunomodulatory effects of granulocyte colony-stimulating factor (G-CSF) on T cells result in a low incidence of acute graft-versus-host disease (aGVHD) in G-CSF-mobilized allogeneic peripheral blood stem...

    Authors: Li Xuan, Xiuli Wu, Dan Qiu, Li Gao, Hui Liu, Zhiping Fan, Fen Huang, Zhenyi Jin, Jing Sun, Yangqiu Li and Qifa Liu

    Citation: Journal of Translational Medicine 2018 16:144

    Published on:

  14. Content type: Research

    Although impaired myeloid-derived suppressor cells (MDSCs) recently have been studied in immune thrombocytopenia (ITP), another myeloid-derived cell population signified as M2 macrophages has not been investig...

    Authors: Xia Shao, Boting Wu, Luya Cheng, Feng Li, Yanxia Zhan, Chanjuan Liu, Lili Ji, Zhihui Min, Yang Ke, Lihua Sun, Hao Chen and Yunfeng Cheng

    Citation: Journal of Translational Medicine 2018 16:48

    Published on:

  15. Content type: Research

    Gene polymorphisms at microRNA-binding sites (poly-miRTS) may affect gene transcription and expression through miRNA regulation, which is associated with cancer susceptibility, sensitivity to chemotherapy and ...

    Authors: Hai-xia Cao, Chao-feng Miao, Liang Yan, Ping Tang, Li-rong Zhang and Ling Sun

    Citation: Journal of Translational Medicine 2017 15:235

    Published on:

  16. Content type: Research

    As one of the major treatment obstacles in Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ALL), relapse of Ph+ALL may result from the persistence of leukemia-propagating cells (LPCs). Research ...

    Authors: Yuan Kong, Yi-Lin Wu, Yang Song, Min-Min Shi, Xie-Na Cao, Hong-Yan Zhao, Ya-Zhen Qin, Yue-Yun Lai, Hao Jiang, Qian Jiang and Xiao-Jun Huang

    Citation: Journal of Translational Medicine 2017 15:184

    Published on:

  17. Content type: Review

    Acute myeloid leukemia (AML) is a heterogenous disease associated with distinct genetic and molecular abnormalities. Somatic mutations result in dysregulation of intracellular signaling pathways, epigenetics, ...

    Authors: Seah H. Lim, Patrycja M. Dubielecka and Vikram M. Raghunathan

    Citation: Journal of Translational Medicine 2017 15:183

    Published on:

  18. Content type: Research

    Cytogenetic aberrations and gene mutations have long been regarded as independent prognostic markers in AML, both of which can lead to misexpression of some key genes related to hematopoiesis. It is believed t...

    Authors: Yong-Mei Zhu, Pan-Pan Wang, Jin-Yan Huang, Yun-Shuo Chen, Bing Chen, Yu-Jun Dai, Han Yan, Yi Hu, Wen-Yan Cheng, Ting-Ting Ma, Sai-Juan Chen and Yang Shen

    Citation: Journal of Translational Medicine 2017 15:178

    Published on:

  19. Content type: Research

    Changes in glucose and energy metabolism contribute to the altered phenotype of cancer cells and are the basis for positron emission tomography with 18F-fluoro-2-deoxy-d-glucose (FDG) to visualize tumors in vivo....

    Authors: Martina Broecker-Preuss, Nina Becher-Boveleth, Andreas Bockisch, Ulrich Dührsen and Stefan Müller

    Citation: Journal of Translational Medicine 2017 15:158

    Published on:

  20. Content type: Research

    Changes in adaptive immune cells after chemotherapy in adult acute myeloid leukemia (AML) may have implications for the success of immunotherapy. This study was designed to determine the functional capacity of...

    Authors: Meghali Goswami, Gabrielle Prince, Angelique Biancotto, Susan Moir, Lela Kardava, Brian H. Santich, Foo Cheung, Yuri Kotliarov, Jinguo Chen, Rongye Shi, Huizhi Zhou, Hana Golding, Jody Manischewitz, Lisa King, Lauren M. Kunz, Kimberly Noonan…

    Citation: Journal of Translational Medicine 2017 15:155

    Published on:

  21. Content type: Research

    Poor graft function (PGF) is a life-threatening complication after allogeneic hematopoietic stem cell transplantation (allo-HSCT). Nevertheless, whether abnormalities of T cell subsets in the bone marrow (BM)...

    Authors: Yuan Kong, Yu-Tong Wang, Xie-Na Cao, Yang Song, Yu-Hong Chen, Yu-Qian Sun, Yu Wang, Xiao-Hui Zhang, Lan-Ping Xu and Xiao-Jun Huang

    Citation: Journal of Translational Medicine 2017 15:57

    Published on:

  22. Content type: Review

    Toll-like receptor 9 (TLR9) is expressed in a variety of B-cell malignancies and works as a bridge between innate and adaptive immunity. CpG oligodeoxynucleotides (CpG ODNs), TLR9 agonists, are able to induce ...

    Authors: Ling Bai, Wei Chen, Jingtao Chen, Wei Li, Lei Zhou, Chao Niu, Wei Han and Jiuwei Cui

    Citation: Journal of Translational Medicine 2017 15:51

    Published on:

  23. Content type: Research

    Acute graft-versus-host disease (aGVHD) remains a major obstacle against favorable clinical outcomes following allogeneic hematopoietic stem cell transplantation (allo-HSCT). T helper cells including Th17 play...

    Authors: Yushi Yao, Lei Wang, Jihao Zhou and Xinyou Zhang

    Citation: Journal of Translational Medicine 2017 15:28

    Published on: