Translational hematology

Section edited by Seah H. Lim 

The Translational hematology section of Journal of Translational Medicine will provide an international platform for presentation of high quality clinical and laboratory translational research, bridging the gap between basic research and pure clinical studies. The scope includes clinical and clinico-pathological investigations and fundamental research of translational potential in hematologic diseases. These include studies in red blood cells, white blood cells, platelets, coagulation, transfusion medicine, and cellular therapy.

We are also dedicated to education by providing a forum for reviews, commentaries, conference summaries and perspectives in new discovery of translational potentials. All submissions are subject to peer review and disclosure requirements. The rapid turn-around time for the processing, review, and publication of all manuscripts will ensure that any novel concepts or findings are current, timely, competitive, and relevant.

This section of the Journal of Translational Medicine will, therefore, be an up-to-date resource for physicians and scientists involved in translational research in hematology and related disciplines.

  1. Research

    Polymorphisms at microRNA binding sites of Ara-C and anthracyclines-metabolic pathway genes are associated with outcome of acute myeloid leukemia patients

    Gene polymorphisms at microRNA-binding sites (poly-miRTS) may affect gene transcription and expression through miRNA regulation, which is associated with cancer susceptibility, sensitivity to chemotherapy and ...

    Hai-xia Cao, Chao-feng Miao, Liang Yan, Ping Tang, Li-rong Zhang and Ling Sun

    Journal of Translational Medicine 2017 15:235

    Published on: 15 November 2017

  2. Research

    Ruxolitinib/nilotinib cotreatment inhibits leukemia-propagating cells in Philadelphia chromosome-positive ALL

    As one of the major treatment obstacles in Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ALL), relapse of Ph+ALL may result from the persistence of leukemia-propagating cells (LPCs). Research ...

    Yuan Kong, Yi-Lin Wu, Yang Song, Min-Min Shi, Xie-Na Cao, Hong-Yan Zhao, Ya-Zhen Qin, Yue-Yun Lai, Hao Jiang, Qian Jiang and Xiao-Jun Huang

    Journal of Translational Medicine 2017 15:184

    Published on: 30 August 2017

  3. Review

    Molecular targeting in acute myeloid leukemia

    Acute myeloid leukemia (AML) is a heterogenous disease associated with distinct genetic and molecular abnormalities. Somatic mutations result in dysregulation of intracellular signaling pathways, epigenetics, ...

    Seah H. Lim, Patrycja M. Dubielecka and Vikram M. Raghunathan

    Journal of Translational Medicine 2017 15:183

    Published on: 29 August 2017

  4. Research

    Gene mutational pattern and expression level in 560 acute myeloid leukemia patients and their clinical relevance

    Cytogenetic aberrations and gene mutations have long been regarded as independent prognostic markers in AML, both of which can lead to misexpression of some key genes related to hematopoiesis. It is believed t...

    Yong-Mei Zhu, Pan-Pan Wang, Jin-Yan Huang, Yun-Shuo Chen, Bing Chen, Yu-Jun Dai, Han Yan, Yi Hu, Wen-Yan Cheng, Ting-Ting Ma, Sai-Juan Chen and Yang Shen

    Journal of Translational Medicine 2017 15:178

    Published on: 22 August 2017

  5. Research

    Regulation of glucose uptake in lymphoma cell lines by c-MYC- and PI3K-dependent signaling pathways and impact of glycolytic pathways on cell viability

    Changes in glucose and energy metabolism contribute to the altered phenotype of cancer cells and are the basis for positron emission tomography with 18F-fluoro-2-deoxy-d-glucose (FDG) to visualize tumors in vivo....

    Martina Broecker-Preuss, Nina Becher-Boveleth, Andreas Bockisch, Ulrich Dührsen and Stefan Müller

    Journal of Translational Medicine 2017 15:158

    Published on: 19 July 2017

  6. Research

    Impaired B cell immunity in acute myeloid leukemia patients after chemotherapy

    Changes in adaptive immune cells after chemotherapy in adult acute myeloid leukemia (AML) may have implications for the success of immunotherapy. This study was designed to determine the functional capacity of...

    Meghali Goswami, Gabrielle Prince, Angelique Biancotto, Susan Moir, Lela Kardava, Brian H. Santich, Foo Cheung, Yuri Kotliarov, Jinguo Chen, Rongye Shi, Huizhi Zhou, Hana Golding, Jody Manischewitz, Lisa King, Lauren M. Kunz, Kimberly Noonan…

    Journal of Translational Medicine 2017 15:155

    Published on: 10 July 2017

  7. Research

    Aberrant T cell responses in the bone marrow microenvironment of patients with poor graft function after allogeneic hematopoietic stem cell transplantation

    Poor graft function (PGF) is a life-threatening complication after allogeneic hematopoietic stem cell transplantation (allo-HSCT). Nevertheless, whether abnormalities of T cell subsets in the bone marrow (BM)...

    Yuan Kong, Yu-Tong Wang, Xie-Na Cao, Yang Song, Yu-Hong Chen, Yu-Qian Sun, Yu Wang, Xiao-Hui Zhang, Lan-Ping Xu and Xiao-Jun Huang

    Journal of Translational Medicine 2017 15:57

    Published on: 14 March 2017

  8. Review

    Heterogeneity of Toll-like receptor 9 signaling in B cell malignancies and its potential therapeutic application

    Toll-like receptor 9 (TLR9) is expressed in a variety of B-cell malignancies and works as a bridge between innate and adaptive immunity. CpG oligodeoxynucleotides (CpG ODNs), TLR9 agonists, are able to induce ...

    Ling Bai, Wei Chen, Jingtao Chen, Wei Li, Lei Zhou, Chao Niu, Wei Han and Jiuwei Cui

    Journal of Translational Medicine 2017 15:51

    Published on: 27 February 2017