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Fibrosis

Section edited by Mary Salvatore

The Fibrosis section aims to gather current high-quality research to better understand the process of normal tissue repair as well as the pathogenetic mechanisms responsible for the onset and progression of tissue fibrosis that leads to organ dysfunction and failure. Fibrosis is the common denominator in a variety of chronic diseases including idiopathic pulmonary fibrosis, liver cirrhosis, and ulcerative colitis, among others. These fibrotic diseases affect a vast number of people across the world significantly impacting the quality of their life and increasing health care costs.

The section will focus on high-quality research from basic science to clinical trials. The expert members of our Editorial Board are committed to ensuring a productive scientific discussion and welcome your thought-provoking contributions to Fibrosis.


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  1. Myocardial fibrosis, a hallmark of heart disease, is closely associated with macrophages, yet the genetic pathophysiology remains incompletely understood. In this study, we utilized integrated single-cell tran...

    Authors: Yong-Zheng Zhang, Yang Wu, Meng-jia Li, Aerzu Mijiti and Lu-Feng Cheng
    Citation: Journal of Translational Medicine 2024 22:839
    Content type: Research Published on:

  3. High levels of lactate are positively associated with prognosis and mortality in pulmonary hypertension (PH). Lactate dehydrogenase A (LDHA) is a key enzyme for the production of lactate. This study is underta...

    Authors: Daiqian Wu, Shuo Wang, Fengxian Wang, Qing Zhang, Zhen Zhang and Xingbing Li
    Citation: Journal of Translational Medicine 2024 22:738
    Content type: Research Published on:

  4. Atrial fibrillation (AF) is associated with increased risk of stroke and mortality. It has been reported that the process of atrial fibrosis was regulated by β-catenin in rats with AF. However, pathophysiologi...

    Authors: Ying Bai, Rui Li, Jun-Feng Hao, Lian-Wan Chen, Si-Tong Liu, Xi-Lin Zhang, Gregory Y. H. Lip, Jin-Kui Yang, Yi-Xi Zou and Hao Wang
    Citation: Journal of Translational Medicine 2024 22:734
    Content type: Research Published on:

  5. Synovial fibrosis is a common complication of knee osteoarthritis (KOA), a pathological process characterized by myofibroblast activation and excessive extracellular matrix (ECM) deposition. Fibroblast-like sy...

    Authors: Taiyang Liao, Lei Shi, Chenglong He, Deren Liu, Yibao Wei, Zhenyuan Ma, Peimin Wang, Jun Mao and Peng Wu
    Citation: Journal of Translational Medicine 2024 22:715
    Content type: Research Published on:

  6. Severe COVID-19 infection has been associated with the development of pulmonary fibrosis, a condition that significantly affects patient prognosis. Understanding the underlying cellular communication mechanism...

    Authors: Lei Guo, Qiong Chen, Mengying Xu, Jing Huang and Hua Ye
    Citation: Journal of Translational Medicine 2024 22:698
    Content type: Research Published on:

  7. Silicosis is an irreversible fibrotic disease of the lung caused by chronic exposure to silica dust, which manifests as infiltration of inflammatory cells, excessive secretion of pro-inflammatory cytokines, an...

    Authors: Tong-Tong Liu, Hai-Fei Sun, Ming-Ze Tang, Hao-Ran Shen, Zhen Shen, Yan-Xing Han, Yun Zhan and Jian-Dong Jiang
    Citation: Journal of Translational Medicine 2024 22:682
    Content type: Research Published on:

  8. Renal interstitial fibrosis (RIF) is a progressive, irreversible terminal kidney disease with a poor prognosis and high mortality. Angiopoietin-like 4 (ANGPTL4) is known to be associated with fibrosis in vario...

    Authors: Yan Li, Shuang Chen, Qian Yang, Xiao Liu, Weiming Zhou, Ting Kang, Weihua Wu and Santao Ou
    Citation: Journal of Translational Medicine 2024 22:649
    Content type: Research Published on:

    The Correction to this article has been published in Journal of Translational Medicine 2024 22:776

  10. Fibrosis is a pathological process involving the abnormal deposition of connective tissue, resulting from improper tissue repair in response to sustained injury caused by hypoxia, infection, or physical damage...

    Authors: Sofia Maria Tarchi, Mary Salvatore, Philip Lichtenstein, Thillai Sekar, Kathleen Capaccione, Lyndon Luk, Hiram Shaish, Jasnit Makkar, Elise Desperito, Jay Leb, Benjamin Navot, Jonathan Goldstein, Sherelle Laifer, Volkan Beylergil, Hong Ma, Sachin Jambawalikar…
    Citation: Journal of Translational Medicine 2024 22:616
    Content type: Review Published on:

  11. Fibrosis is the aberrant process of connective tissue deposition from abnormal tissue repair in response to sustained tissue injury caused by hypoxia, infection, or physical damage. It can affect almost all or...

    Authors: Sofia Maria Tarchi, Mary Salvatore, Philip Lichtenstein, Thillai Sekar, Kathleen Capaccione, Lyndon Luk, Hiram Shaish, Jasnit Makkar, Elise Desperito, Jay Leb, Benjamin Navot, Jonathan Goldstein, Sherelle Laifer, Volkan Beylergil, Hong Ma, Sachin Jambawalikar…
    Citation: Journal of Translational Medicine 2024 22:610
    Content type: Review Published on:

  12. Sustained injury from factors such as hypoxia, infection, or physical damage may provoke improper tissue repair and the anomalous deposition of connective tissue that causes fibrosis. This phenomenon may take ...

    Authors: Sofia Maria Tarchi, Mary Salvatore, Philip Lichtenstein, Thillai Sekar, Kathleen Capaccione, Lyndon Luk, Hiram Shaish, Jasnit Makkar, Elise Desperito, Jay Leb, Benjamin Navot, Jonathan Goldstein, Sherelle Laifer, Volkan Beylergil, Hong Ma, Sachin Jambawalikar…
    Citation: Journal of Translational Medicine 2024 22:609
    Content type: Review Published on:

  13. CCN4 (cellular communication network factor 4), a highly conserved, secreted cysteine-rich matricellular protein is emerging as a key player in the development and progression of numerous disease pathologies, ...

    Authors: Kirti Singh and Sunday S. Oladipupo
    Citation: Journal of Translational Medicine 2024 22:601
    Content type: Review Published on:

  14. Interstitial lung disease (ILD) is the primary cause of mortality in systemic sclerosis (SSc), an autoimmune disease characterized by tissue fibrosis. SSc-related ILD (SSc-ILD) occurs more frequently in female...

    Authors: Shih-Ching Lee, Chen-Hao Huang, Yen-Jen Oyang, Hsuan-Cheng Huang and Hsueh-Fen Juan
    Citation: Journal of Translational Medicine 2024 22:600
    Content type: Research Published on:

  15. Monocyte-derived alveolar macrophages (Mo_AMs) are increasingly recognised as potential pathogenic factors for idiopathic pulmonary fibrosis (IPF). While scRNAseq analysis has proven valuable in the transcript...

    Authors: Miaomiao Zhang, Jinghao Zhang, Haisheng Hu, Yuan Zhou, ZhiWei Lin, Hui Jing and Baoqing Sun
    Citation: Journal of Translational Medicine 2024 22:598
    Content type: Research Published on:

  16. The transforming growth factor-beta (TGF-β) signaling pathway is a vital regulator of cell proliferation, differentiation, apoptosis, and extracellular matrix production. It functions through canonical SMAD-me...

    Authors: Anna O. Giarratana, Conor M. Prendergast, Mary M. Salvatore and Kathleen M. Capaccione
    Citation: Journal of Translational Medicine 2024 22:594
    Content type: Review Published on:

  17. Both cancer and fibrosis are diseases involving dysregulation of cell signaling pathways resulting in an altered cellular microenvironment which ultimately leads to progression of the condition. The two diseas...

    Authors: Alireza Baniasadi, Jeeban P. Das, Conor M. Prendergast, Zahra Beizavi, Hong Y. Ma, Muhammad Yaman Jaber and Kathleen M. Capaccione
    Citation: Journal of Translational Medicine 2024 22:567
    Content type: Review Published on:

  18. Fibrogenesis within ovarian endometrioma (endometrioma), mainly induced by transforming growth factor-β (TGF-β), is characterized by myofibroblast over-activation and excessive extracellular matrix (ECM) depos...

    Authors: Yi Gong, Mian Liu, Qianqian Zhang, Jinjing Li, Hong Cai, Jing Ran, Linna Ma, Yanlin Ma and Song Quan
    Citation: Journal of Translational Medicine 2024 22:561
    Content type: Research Published on:

  19. The pathogenesis of thyroid-associated orbitopathy (TAO) remains incompletely understand. The interaction between immunocytes and orbital fibroblasts (OFs) play a critical role in orbital inflammatory and fibr...

    Authors: Li Wei, Qinying Huang, Yunhai Tu, Shihan Song, Xiaobo Zhang, Bo Yu, Yufen Liu, Ziwei Li, Qing Huang, Lili Chen, Bo Liu, Shenglan Xu, Tong Li, Xiyuan Liu, Xiaozhou Hu, Weijie Liu…
    Citation: Journal of Translational Medicine 2024 22:546
    Content type: Research Published on:

  20. Diabetic cardiomyopathy (DCM), a serious complication of diabetes, leads to structural and functional abnormalities of the heart and ultimately evolves to heart failure. IL-37 exerts a substantial influence on...

    Authors: Qingyu Huang, Tongqing Chen, Jian Li, Yiming Wang, Huairui Shi, Yifei Yu, Qingwei Ji, Xiaoyan Shen, Tao Sun, Haiming Shi, Xinping Luo, Bo Jin, Yan You and Bangwei Wu
    Citation: Journal of Translational Medicine 2024 22:494
    Content type: Research Published on:

  21. Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive, fibrotic interstitial lung diseases, which mainly existed in middle-aged and elderly people. The accumulation of reactive oxygen species (ROS) is ...

    Authors: Zhiheng Sun, Zhihua Ji, Huiwen Meng, Wanyu He, Bin Li, Xiaoyue Pan, Yanlin Zhou and Guoying Yu
    Citation: Journal of Translational Medicine 2024 22:479
    Content type: Research Published on:

  22. Interstitial lung disease (ILD) represents a significant complication of rheumatoid arthritis (RA) that lacks effective treatment options. This study aimed to investigate the intrinsic mechanism by which resve...

    Authors: Nannan Liu, Xuefei Fan, Yubao Shao, Suhuan Chen, Taorong Wang, Tao Yao and Xiaoyu Chen
    Citation: Journal of Translational Medicine 2024 22:457
    Content type: Research Published on:

  23. Endometriosis, characterized by the presence of active endometrial-like tissues outside the uterus, causes symptoms like dysmenorrhea and infertility due to the fibrosis of endometrial cells, which involves ex...

    Authors: Mengjie Yang, Hong Jiang, Xinyu Ding, Lu Zhang, Huaying Zhang, Jiahao Chen, Lijun Li, Xinqin He, Zhixiong Huang and Qionghua Chen
    Citation: Journal of Translational Medicine 2024 22:445
    Content type: Research Published on:

  24. To explore the impact of microRNA 146a (miR-146a) and the underlying mechanisms in profibrotic changes following glaucoma filtering surgery (GFS) in rats and stimulation by transforming growth factor (TGF)-β1 ...

    Authors: Ruiqi Han, Huimin Zhong, Yang Zhang, Huan Yu, Yumeng Zhang, Shouyue Huang, Zijian Yang and Yisheng Zhong
    Citation: Journal of Translational Medicine 2024 22:440
    Content type: Research Published on:

  25. Tumors are highly complex and heterogenous ecosystems where malignant cells interact with healthy cells and the surrounding extracellular matrix (ECM). Solid tumors contain large ECM deposits that can constitu...

    Authors: Rowie Borst, Linde Meyaard and M. Ines Pascoal Ramos
    Citation: Journal of Translational Medicine 2024 22:382
    Content type: Review Published on:

  26. MicroRNA (miRNA)-21-5p participates in various biological processes, including cancer and autoimmune diseases. However, its role in the development of fibrosis in the in vivo model of systemic sclerosis (SSc) ...

    Authors: Jin-Sil Park, Chongtae Kim, JeongWon Choi, Ha Yeon Jeong, Young-Mee Moon, Hoin Kang, Eun Kyung Lee, Mi-La Cho and Sung-Hwan Park
    Citation: Journal of Translational Medicine 2024 22:323
    Content type: Research Published on:

  27. Paraquat (PQ) is a widely used and highly toxic herbicide that poses a significant risk to human health. The main consequence of PQ poisoning is pulmonary fibrosis, which can result in respiratory failure and ...

    Authors: Min Zhang, Xiang Xue, Zhenshuai Lou, Yanhong Lin, Qian Li and Changbao Huang
    Citation: Journal of Translational Medicine 2024 22:310
    Content type: Research Published on:

  28. The aberrant secretion and excessive deposition of type I collagen (Col1) are important factors in the pathogenesis of myocardial fibrosis in dilated cardiomyopathy (DCM). However, the precise molecular mechan...

    Authors: Hongjie Shi, Ming Yuan, Jie Cai, Lan Lan, Yumou Wang, Wei Wang, Jianliang Zhou, Bin Wang, Wenjun Yu, Zhe Dong, Dawei Deng, Qiaofeng Qian, Yang Li, Xianwu Zhou and Jinping Liu
    Citation: Journal of Translational Medicine 2024 22:297
    Content type: Research Published on:

  29. Idiopathic Pulmonary Fibrosis (IPF) is a type of chronic interstitial pneumonia, often fatal, with elusive causes and a bleak prognosis. Its treatment options are limited and largely ineffective. Early detecti...

    Authors: Wenhua Gan, Wenwen Song, Yujuan Gao, Xuexue Zheng, Fengjuan Wang, Zirui Zhang, Ke Zen, Hongwei Liang and Xin Yan
    Citation: Journal of Translational Medicine 2024 22:264
    Content type: Research Published on:

  30. Peritoneal fibrosis is the prevailing complication induced by prolonged exposure to high glucose in patients undergoing peritoneal dialysis.

    Authors: Qiong Song, Pengbo Wang, Huan Wang, Meijing Pan, Xiujuan Li, Zhuan’e Yao, Wei Wang, Guangbo Tang and Sen Zhou
    Citation: Journal of Translational Medicine 2024 22:243
    Content type: Research Published on:

  31. Kidney transplantation stands out as the most effective renal replacement therapy for patients grappling with end-stage renal disease. However, post-transplant renal fibrosis is a prevalent and irreversible co...

    Authors: Xinhao Niu, Cuidi Xu, Yin Celeste Cheuk, Xiaoqing Xu, Lifei Liang, Pingbao Zhang and Ruiming Rong
    Citation: Journal of Translational Medicine 2024 22:186
    Content type: Research Published on:

  32. The need for radiotherapy among the elderly rises with increasing life expectancy and a corresponding increase of elderly cancer patients. Radiation-induced skin injury is one of the most frequent adverse effe...

    Authors: Yan Chen, Le Ma, Zhuo Cheng, Zhihe Hu, Yang Xu, Jie Wu, Yali Dai and Chunmeng Shi
    Citation: Journal of Translational Medicine 2024 22:176
    Content type: Research Published on:

  33. The autophagy adapter SQSTM1/p62 is crucial for maintaining homeostasis in various organs and cells due to its protein–protein interaction domains and involvement in diverse physiological and pathological proc...

    Authors: Jing Feng, Yan Li, Yu Zhang, Shengnan Sun, Jian Sun, Quanlin Xu, Xingzhao Ji, Yi Liu and Qiang Wan
    Citation: Journal of Translational Medicine 2024 22:161
    Content type: Research Published on:

  34. Pulmonary hypertension (PH) is a complex multifactorial vascular pathology characterized by an increased pulmonary arterial pressure, vasoconstriction, remodelling of the pulmonary vasculature, thrombosis in s...

    Authors: Ioana Karla Comarița, Gabriela Tanko, Iliuță Laurențiu Anghelache and Adriana Georgescu
    Citation: Journal of Translational Medicine 2024 22:137
    Content type: Research Published on:

  35. Esophageal strictures significantly impair patient quality of life and present a therapeutic challenge, particularly due to the high recurrence post-ESD/EMR. Current treatments manage symptoms rather than addr...

    Authors: Fang Yang, Yiwei Hu, Zewen Shi, Mujie Liu, Kefeng Hu, Guoliang Ye, Qian Pang, Ruixia Hou, Keqi Tang and Yabin Zhu
    Citation: Journal of Translational Medicine 2024 22:123
    Content type: Review Published on:

  36. Liver fibrosis contributes to significant morbidity and mortality in Western nations, primarily attributed to chronic hepatitis C virus (HCV) infection. Hypoxia and immune status have been reported to be signi...

    Authors: Chuwen Chen, Haozheng Cai, Junyi Shen, Xiaoyun Zhang, Wei Peng, Chuan Li, Haopeng Lv and Tianfu Wen
    Citation: Journal of Translational Medicine 2024 22:116
    Content type: Research Published on:

  37. Idiopathic pulmonary fibrosis (IPF) is a globally prevalent, progressive disease with limited treatment options and poor prognosis. Because of its irreversible disease progression, IPF affects the quality and ...

    Authors: Jie Tan, Qianfei Xue, Xiao Hu and Junling Yang
    Citation: Journal of Translational Medicine 2024 22:95
    Content type: Review Published on:

  38. Nonalcoholic steatohepatitis (NASH) is a progressive manifestation of nonalcoholic fatty liver disease (NAFLD) that can lead to fibrosis, cirrhosis, and hepatocellular carcinoma (HCC). Despite the growing know...

    Authors: Yuan Ni, Maoqing Lu, Ming Li, Xixi Hu, Feng Li, Yan Wang and Dong Xue
    Citation: Journal of Translational Medicine 2024 22:72
    Content type: Research Published on:

  39. Evaluate the behavior of lung nodules occurring in areas of pulmonary fibrosis and compare them to pulmonary nodules occurring in the non-fibrotic lung parenchyma.

    Authors: Mary M. Salvatore, Yucheng Liu, Boyu Peng, Hao Yun Hsu, Anjali Saqi, Wei-Yann Tsai, Cheng-Shiun Leu and Sachin Jambawalikar
    Citation: Journal of Translational Medicine 2024 22:67
    Content type: Research Published on:

  40. Osteoarthritis (OA) is a chronic degenerative disease resulting joint disability and pain. Accumulating evidences suggest that chondrocyte extracellular matrix calcification plays an important role in the deve...

    Authors: Rong Peng, Jie Shang, Ning Jiang, Hsu Chi-Jen, Yu Gu, Baizhou Xing, Renan Hu, Biao Wu, Dawei Wang, Xianghe Xu and Huading Lu
    Citation: Journal of Translational Medicine 2024 22:52
    Content type: Research Published on:

  41. Upper tract urothelial carcinoma (UTUC) is a rare disease, belonging to the same category of urothelial cancers as bladder cancer (BC). Despite sharing similar non-surgical treatment modalities, UTUC demonstra...

    Authors: Keqiang Li, Zhenlin Huang, Guoqing Xie, Budeng Huang, Liang Song, Yu Zhang and Jinjian Yang
    Citation: Journal of Translational Medicine 2024 22:24
    Content type: Research Published on:

  42. Chronic lung diseases include an array of conditions that impact airways and lung structures, leading to considerable societal burdens. Mesenchymal stem cells (MSCs) and their exosomes (MSC-exos) can be used f...

    Authors: Zhengyao Zhai, Tairong Cui, Jialiang Chen, Xulong Mao and Ting Zhang
    Citation: Journal of Translational Medicine 2023 21:895
    Content type: Review Published on:

  43. Chronic obstructive pulmonary disease (COPD) has impacted approximately 390 million people worldwide and the morbidity is increasing every year. However, due to the poor treatment efficacy of COPD, exploring n...

    Authors: Wenhua Wang, Huaihuai Peng, Menghao Zeng, Jie Liu, Guibin Liang and Zhihui He
    Citation: Journal of Translational Medicine 2023 21:881
    Content type: Research Published on:

  44. The use of umbilical cord mesenchymal stem cells (UC-MSCs) is a burgeoning method for the treatment of liver cirrhosis. However, the secretory phenotype and regulatory ability of UC-MSCs are easily affected by...

    Authors: Ye Xie, Jia Yao, Mengchao Yan, Yan Lin, Jiayun Wei, Haiping Wang, Yongcui Mao, Pinyan Liu and Xun Li
    Citation: Journal of Translational Medicine 2023 21:832
    Content type: Research Published on:

  46. Idiopathic pulmonary fibrosis (IPF) is the most common idiopathic interstitial lung disease. Clinical models to accurately evaluate the prognosis of IPF are currently lacking. This study aimed to construct an ...

    Authors: Xiaoyun Cheng, Zhichao Feng, Boyu Pan, Qingxiang Liu, Yuanyuan Han, Lijun Zou, Pengfei Rong and Jie Meng
    Citation: Journal of Translational Medicine 2023 21:805
    Content type: Research Published on:

  47. The exact mechanism and target molecules of liver fibrosis have remained largely elusive. Here, we investigated the role of long noncoding RNA Gm9866(lncRNA-Gm9866) on liver fibrosis.

    Authors: Xiaomin Liao, Xianxian Ruan, Peishan Yao, Dan Yang, Xianbin Wu, Xia Zhou, Jie Jing, Dafu Wei, Yaodan Liang, Taicheng Zhang, Shanyu Qin and Haixing Jiang
    Citation: Journal of Translational Medicine 2023 21:778
    Content type: Research Published on:

  48. Hepatic ischemia–reperfusion (IR) injury is the primary reason for complications following hepatectomy and liver transplantation (LT). Insulin-induced gene 2 (Insig2) is one of several proteins that anchor the...

    Authors: Yichao Wu, Changbiao Li, Abid Ali Khan, Kangchen Chen, Renyi Su, Shengjun Xu, Yiyang Sun, Fengqiang Gao, Kai Wang, Xiaodong Wang, Zhengxing Lian, Shuo Wang, Mengyuan Yu, Xin Hu, Fan Yang, Shusen Zheng…
    Citation: Journal of Translational Medicine 2023 21:739
    Content type: Research Published on:

  49. Cancer remains the leading cause of death around the world. In cancer treatment, over 50% of cancer patients receive radiotherapy alone or in multimodal combinations with other therapies. One of the adverse co...

    Authors: Zuxiang Yu, Chaoyu Xu, Bin Song, Shihao Zhang, Chong Chen, Changlong Li and Shuyu Zhang
    Citation: Journal of Translational Medicine 2023 21:708
    Content type: Review Published on:

  50. Bone marrow fibrosis represents an important structural change in the marrow that interferes with some of its normal functions. The aetiopathogenesis of fibrosis is not well established except in its primary f...

    Authors: Kanjaksha Ghosh, Durjoy K. Shome, Bipin Kulkarni, Malay K. Ghosh and Kinjalka Ghosh
    Citation: Journal of Translational Medicine 2023 21:703
    Content type: Review Published on:

Journal of Translational Medicine

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