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Translational Metagenomics

Section edited by Souhaila Al Khodor

© Kateryna_Kon / stock.adobe.comThe Translational Metagenomics section aims to embrace studies addressing the role of the human microbiome in health and disease. This section encompasses studies about the development and application of metagenomics, metatranscriptomics, microbial metabolomics or novel bioinformatics tools used to improve our knowledge on the microbiome. 

The Translational Metagenomics section is especially interested in studies that go beyond description of the microbial composition and include experimental models used to support the proposed role of the microbiome in human health and diseases. In addition, studies about metagenomics integration with other omics are highly recommended. Studies of pathogens interaction with the host will not be considered.

  1. Integrative analysis approaches of metagenomics and metabolomics have been widely developed to understand the association between disease and the gut microbiome. However, the different profiling patterns of di...

    Authors: Lanlan Zhao, Cheng Wang, Shanxin Peng, Xiaosong Zhu, Ziyi Zhang, Yanyan Zhao, Jinling Zhang, Guoping Zhao, Tao Zhang, Xueyuan Heng and Lei Zhang
    Citation: Journal of Translational Medicine 2022 20:459
  2. Globally, gastric cancer is the third most common cancer and the third leading cause of cancer death. Proximal and distal gastric cancers have distinct clinical and biological behaviors. The microbial composit...

    Authors: Yan Yang, Daofeng Dai, Wen Jin, Yingying Huang, Yingzi Zhang, Yiran Chen, Wankun Wang, Wu Lin, Xiangliu Chen, Jing Zhang, Haohao Wang, Haibin Zhang and Lisong Teng
    Citation: Journal of Translational Medicine 2022 20:439
  3. The pathogenesis of kidney stone disease (KSD) is not fully understood, and potential contributing factors remain to be explored. Several studies have revealed that the urinary microbiome (urobiome) of stone f...

    Authors: Sen-Yuan Hong, Yuan-Yuan Yang, Jin-Zhou Xu, Qi-Dong Xia, Shao-Gang Wang and Yang Xun
    Citation: Journal of Translational Medicine 2022 20:431
  4. In recent years, there has been a greater emphasis on the impact of microbial populations inhabiting the gastrointestinal tract on human health and disease. According to the involvement of microbiota in modula...

    Authors: Hourieh Sadrekarimi, Zhanna R. Gardanova, Morteza Bakhshesh, Farnoosh Ebrahimzadeh, Amirhossein Fakhre Yaseri, Lakshmi Thangavelu, Zahra Hasanpoor, Firoozeh Abolhasani Zadeh and Mohammad Saeed Kahrizi
    Citation: Journal of Translational Medicine 2022 20:301
  5. Chronic obstructive pulmonary disease (COPD), a prevalent, progressive respiratory disease, has become the third leading cause of death globally. Increasing evidence suggests that intestinal and pulmonary micr...

    Authors: Yu Jia, Tiantian He, Di Wu, Jiabing Tong, Jie Zhu, Zegeng Li and Jingcheng Dong
    Citation: Journal of Translational Medicine 2022 20:281
  6. Metagenomic next-generation sequencing (mNGS) is an important supplement to conventional tests for pathogen detections of pneumonia. However, mNGS pipelines were limited by irregularities, high proportion of h...

    Authors: Yukun He, Kechi Fang, Xing Shi, Donghong Yang, Lili Zhao, Wenyi Yu, Yali Zheng, Yu Xu, Xinqian Ma, Li Chen, Yu Xie, Yan Yu, Jing Wang and Zhancheng Gao
    Citation: Journal of Translational Medicine 2022 20:195
  7. The human microbiome has been linked to several diseases. Gastrointestinal diseases are still one of the most prominent area of study in host-microbiome interactions however the underlying microbial mechanisms...

    Authors: Pouyan Ghaffari, Saeed Shoaie and Lars K. Nielsen
    Citation: Journal of Translational Medicine 2022 20:173
  8. The human gastrointestinal tract is inhabited by the largest microbial community within the human body consisting of trillions of microbes called gut microbiota. The normal flora is the site of many physiologi...

    Authors: Prisca Gebrayel, Carole Nicco, Souhaila Al Khodor, Jaroslaw Bilinski, Elisabetta Caselli, Elena M. Comelli, Markus Egert, Cristina Giaroni, Tomasz M. Karpinski, Igor Loniewski, Agata Mulak, Julie Reygner, Paulina Samczuk, Matteo Serino, Mariusz Sikora, Annalisa Terranegra…
    Citation: Journal of Translational Medicine 2022 20:111
  9. Significant links between the microbiota and human health have emerged in the last 20 years. A correlation has recently been demonstrated between changes in the gut microbiota and the development of cancer. Th...

    Authors: Sa’ed H. Zyoud, Samah W. Al-Jabi, Riad Amer, Muna Shakhshir, Moyad Shahwan, Ammar A. Jairoun, Maha Akkawi and Adham Abu Taha
    Citation: Journal of Translational Medicine 2022 20:83
  10. Chronic obstructive pulmonary disease (COPD) is a prevalent, progressive respiratory disease, and acute exacerbations of COPD (AECOPD) can accelerate the deterioration of the disease. Increasing evidence sugge...

    Authors: Linfan Su, Yixian Qiao, Jinmei Luo, Rong Huang, Zhiwei Li, Hongbing Zhang, Hongmei Zhao, Jing Wang and Yi Xiao
    Citation: Journal of Translational Medicine 2022 20:76
  11. The treatment of sepsis remains a major challenge worldwide. Aminophylline has been shown to have anti-inflammatory effects; however, the role of aminophylline in sepsis, a disease characterized by immune dysr...

    Authors: Yuanzhe Li, Huayan Zhao, Guiying Sun, Yongtao Duan, Yanjun Guo, Lina Xie and Xianfei Ding
    Citation: Journal of Translational Medicine 2022 20:69
  12. It is widely acknowledged that gastric cancer seriously affects the quality of life and survival of patients. The correlation between the microbiota and gastric cancer has attracted extensive attention in rece...

    Authors: Yan Yang, Yingying Huang, Wu Lin, Jin Liu, Xiangliu Chen, Chuanzhi Chen, Xiongfei Yu and Lisong Teng
    Citation: Journal of Translational Medicine 2022 20:52
  13. Compelling evidences demonstrated that gut microbiota dysbiosis plays a critical role in the pathogenesis of inflammatory bowel diseases (IBD). Therapies for targeting the microbiota may provide alternative op...

    Authors: Fang Dong, Fangfei Xiao, Xiaolu Li, Youran Li, Xufei Wang, Guangjun Yu, Ting Zhang and Yizhong Wang
    Citation: Journal of Translational Medicine 2022 20:33
  14. Multiple myeloma is characterized by osteolytic lesions caused by reduced bone formation and activated bone resorption. An important feature of myeloma is a failure of bone healing after successful treatment. ...

    Authors: Rui Liu, Yuping Zhong, Rui Chen, Shiyi Chen, Yazhu Huang and Huan Liu
    Citation: Journal of Translational Medicine 2022 20:16
  15. The status of vaginal microbiota in persistent high-risk human papilloma virus (HR-HPV) infection is unclear. The present work aimed to identify the vaginal microbiota of persistent HPV infection and explore t...

    Authors: Ling Mei, Tao Wang, Yueyue Chen, Dongmei Wei, Yueting Zhang, Tao Cui, Jian Meng, Xiaoli Zhang, Yuqing Liu, Lisha Ding and Xiaoyu Niu
    Citation: Journal of Translational Medicine 2022 20:12
  16. Necrotizing enterocolitis (NEC) remains a life-threatening disease in neonates. Numerous studies have shown a correlation between the intestinal microbiota and NEC, but the causal link remains unclear. This study...

    Authors: Yu He, Weixia Du, Sa Xiao, Benhua Zeng, Xiang She, Dong Liu, Hua Du, Luquan Li, Fang Li, Qing Ai, Junli He, Chao Song, Hong Wei, Xiaodong Zhao and Jialin Yu
    Citation: Journal of Translational Medicine 2021 19:510
  17. In recent years, the incidence rate of Thyroid carcinoma (TC) has been increasing worldwide. Thus, research on factors of TC carcinogenesis may promote TC prevention and decrease the incidence rate. There are ...

    Authors: Daofeng Dai, Yan Yang, Yong Yang, Tianfeng Dang, Jiansheng Xiao, Weibin Wang, Lisong Teng, Juan Xu, Jing Ye and Hongqun Jiang
    Citation: Journal of Translational Medicine 2021 19:488
  18. Comparing the microbiome compositions obtained under different physiological conditions has frequently been attempted in recent years to understand the functional influence of microbiomes in the occurrence of ...

    Authors: Sukjung Choi, Jongsuk Chung, Mi-La Cho, Donghyun Park and Sun Shim Choi
    Citation: Journal of Translational Medicine 2021 19:485
  19. The causes of gestational diabetes mellitus (GDM) are still unclear. Recent studies have found that the imbalance of the gut microbiome could lead to disorders of human metabolism and immune system, resulting ...

    Authors: Yao Su, Hong-Kun Wang, Xu-Pei Gan, Li Chen, Yan-Nan Cao, De-Cui Cheng, Dong-Yao Zhang, Wen-Yu Liu, Fei-Fei Li and Xian-Ming Xu
    Citation: Journal of Translational Medicine 2021 19:366
  20. Inflammatory bowel diseases (IBD), mainly comprising ulcerative colitis (UC) and Crohn's Disease, are most often a polygenic disorder with contributions from the intestinal microbiome, defects in barrier funct...

    Authors: Juan Huang, Ziyan Yang, Yanyun Li, Xingxing Chai, Yanfang Liang, Bihua Lin, Ziyu Ye, Shaobing Zhang, Zhengping Che, Hailiang Zhang, Xueying Zhang, Zhao Zhang, Tao Chen, Weiqing Yang and Jincheng Zeng
    Citation: Journal of Translational Medicine 2021 19:356
  21. The gastrointestinal microbiome is an important component of the human body and is closely related to human health and disease. This study describes the hotspots of the human gastrointestinal microbiome resear...

    Authors: Xingzhu Yuan, Chengting Chang, Xinrong Chen and Ka Li
    Citation: Journal of Translational Medicine 2021 19:327
  22. Constipation is a common gastrointestinal dysfunction which has a potential impact on people's immune state and their quality of life. Here we investigated the effects of constipation on experimental autoimmun...

    Authors: Xiuli Lin, Yingying Liu, Lili Ma, Xiaomeng Ma, Liping Shen, Xueying Ma, Zhaoyu Chen, Hao Chen, Donghong Li, Zhumin Su and Xiaohong Chen
    Citation: Journal of Translational Medicine 2021 19:317
  23. The fecal microbiota in pancreatic ductal adenocarcinoma (PDAC) and in autoimmune pancreatitis (AIP) patients remains largely unknown. We aimed to characterize the fecal microbiota in patients with PDAC and AI...

    Authors: Wenli Zhou, De Zhang, Zhengpeng Li, Huiqing Jiang, Jingnan Li, Rongrong Ren, Xuefeng Gao, Jianfeng Li, Xin Wang, Weifeng Wang and Yunsheng Yang
    Citation: Journal of Translational Medicine 2021 19:215