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Translational Cancer Biology

Section edited by Cristina Maccalli

This section aims to provide a platform for the communication and dissemination of advances in cancer biology and their translational applications. Studies considered for publication include those dissecting the mechanisms of transformation, progression and metastatization, the biology of cancer stem cells and their immunological properties, the mechanisms undergoing the epithelial-to mesenchymal (EMT) transition and tumor dormancy, their relationship with immune functions and the mechanisms undergoing cancer resistance to therapies. 

This section is also dedicated to those investigations dedicated to the translational aspects and the development of novel therapies related to the aforementioned themes and the identification of patient’s responsiveness and outcome to therapies.

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  1. Ladinin-1 (LAD1), an anchoring filament protein, has been associated with several cancer types, including cancers of the colon, lungs, and breast. However, it is still unclear how and why LAD1 causes gastric c...

    Authors: Yingming Jiang, Yanchun Feng, Jintuan Huang, Zhenze Huang, Rongchang Tan, Tuoyang Li, Zijian Chen, Xiaocheng Tang, Jun Qiu, Chujun Li, Hao Chen and Zuli Yang
    Citation: Journal of Translational Medicine 2023 21:632
  2. Increasing evidence suggests that hepatocellular carcinoma (HCC) stem cells (LCSCs) play an essential part in HCC recurrence, metastasis, and chemotherapy and radiotherapy resistance. Multiple studies have dem...

    Authors: Rui Liang, Weifeng Hong, Yang Zhang, Di Ma, Jinwei Li, Yisong Shi, Qing Luo, Shisuo Du and Guanbin Song
    Citation: Journal of Translational Medicine 2023 21:631
  3. Fibroblast growth factor receptor (FGFR) gene family alterations are found in several cancers, indicating their importance as potential therapeutic targets. The FGFR-tyrosine kinase inhibitor (TKI) pemigatinib...

    Authors: Angelica Pace, Fabio Scirocchi, Chiara Napoletano, Ilaria Grazia Zizzari, Agnese Po, Francesca Megiorni, Angela Asquino, Paola Pontecorvi, Hassan Rahimi, Cinzia Marchese, Elisabetta Ferretti, Marianna Nuti and Aurelia Rughetti
    Citation: Journal of Translational Medicine 2023 21:626
  4. Colorectal cancer (CRC) has become a global health problem which has almost highest morbidity and mortality in all types of cancers. This study aimed to uncover the biological functions and underlying mechanis...

    Authors: Shaojun Yu, Weixing Dai, Senlin Zhao, Yongzhi Yang, Ye Xu, Jianwei Wang, Qun Deng, Jinghu He and Debing Shi
    Citation: Journal of Translational Medicine 2023 21:623
  5. A chromobox homologue 3 (CBX3) is elevated in various cancers and significantly contributes to the promotion of malignant behavior; despite this, its exact involvement in clear cell renal cell carcinoma (ccRCC...

    Authors: Jiasheng Chen, Yuxin Lin, Shukai zheng, Qingshan Chen, Shijie Tang and Xiaoping Zhong
    Citation: Journal of Translational Medicine 2023 21:600
  6. Pancreatic ductal adenocarcinoma (PDAC) is expected to soon surpass colorectal cancer as a leading cause of cancer mortality in both males and females in the US, only lagging behind lung cancer. The lethality ...

    Authors: Nuno Bastos, Stéphanie A. Castaldo, Bárbara Adem, José C. Machado, Carlos A. Melo and Sonia A. Melo
    Citation: Journal of Translational Medicine 2023 21:578
  7. Alpha-melanocyte stimulating hormone (α-MSH) and its receptor, melanocortin 1 receptor (MC1R), have been proposed as potential target for anti-cancer strategies in melanoma research, due to their tissue specif...

    Authors: Luigi Dall’Olmo, Nicole Papa, Nicoletta Concetta Surdo, Ilaria Marigo and Simone Mocellin
    Citation: Journal of Translational Medicine 2023 21:562
  8. Hepatocellular carcinoma (HCC) is one of the most prevalent malignancies worldwide because of rapid progression and high incidence of metastasis or recurrence. Accumulating evidence shows that CD58-expressing ...

    Authors: Chuanzheng Wang, Fei Cao, Jiahao Cao, Zhen Jiao, Yuting You, Yu Xiong, Wenxiu Zhao and Xiaomin Wang
    Citation: Journal of Translational Medicine 2023 21:539
  9. Epithelial cell adhesion molecule (EpCAM) is known to highly expression and promotes cancer progression in many cancer types, including colorectal cancer. While metastasis is one of the main causes of cancer t...

    Authors: Chi-Chiu Lee, Chia-Jui Yu, Sushree Shankar Panda, Kai-Chi Chen, Kang-Hao Liang, Wan-Chen Huang, Yu-Shiuan Wang, Pei-Chin Ho and Han-Chung Wu
    Citation: Journal of Translational Medicine 2023 21:530
  10. Breast cancer (BC) has posed a great threat to world health as the leading cause of cancer death among women. Previous evidence demonstrated that germ cell-specific gene 2 (GSG2) was involved in the regulation...

    Authors: Yu Tang, Gaosai Dai, Yupeng Yang and Huantao Liu
    Citation: Journal of Translational Medicine 2023 21:523
  11. Programmed cell death (PCD) plays an important role in many aspects of individual development, maintenance of body homeostasis and pathological processes. Ferroptosis is a novel form of PCD characterized by th...

    Authors: Qi Zhang, Xinfeng Fan, Xinyu Zhang and Shaoqing Ju
    Citation: Journal of Translational Medicine 2023 21:514
  12. Bladder cancer is one of the most common malignant tumors of the urinary system and is associated with a poor prognosis once invasion and distant metastases occur. Epithelial-mesenchymal transition (EMT) drive...

    Authors: Qinrong Ping, Chunhui Wang, Xin Cheng, Yiming Zhong, Ruping Yan, Meng Yang, Yunqiang Shi, Xiangmeng Li, Xiao Li, Wenwen Huang, Liqiong Wang, Xiaofang Bi, Libing Hu, Yang Yang, Yingbao Wang, Rui Gong…
    Citation: Journal of Translational Medicine 2023 21:475
  13. The glycosyltransferase CHSY3 is a CHSY family member, yet its importance in the context of gastric cancer development remains incompletely understood. The present study was thus developed to explore the mecha...

    Authors: Xinkun Huang, Yonghui Liu, Chenyu Qian, Qicheng Shen, Menglong Wu, Bin Zhu and Ying Feng
    Citation: Journal of Translational Medicine 2023 21:474
  14. Epithelial ovarian cancer is the leading cause of death from gynecologic cancer, in which serous ovarian carcinoma (SOC) is the most common histological subtype. Although PARP inhibitors (PARPi) and antiangiog...

    Authors: Xiaohui Yang, Minying Zheng, Yidi Ning, Jie Sun, Yongjun Yu and Shiwu Zhang
    Citation: Journal of Translational Medicine 2023 21:456
  15. USP51 is a deubiquitinase (DUB), that is involved in diverse cellular processes. Accumulating evidence has demonstrated that USP51 contributes to cancer development. However, its impact on non-small cell lung ...

    Authors: Jin Chen, Zhongqiu Wu, Wenyi Deng, Minying Tang, Lvying Wu, Na Lin, Liuyan Chen, Yunfeng Fu, Min Zhao, Changguo Chen and Wenting Li
    Citation: Journal of Translational Medicine 2023 21:453
  16. Aberrant ubiquitin-proteasome system (UPS) triggers various disorders of biological events and contributes to progression of tumorigenesis. The tripartite motif containing 22 (TRIM22) was demonstrated to parti...

    Authors: Xiaoli Gu, Wei Min, Yibin Zeng, Ni Fan and Qihong Qian
    Citation: Journal of Translational Medicine 2023 21:443
  17. Intra-tumoral heterogeneity (ITH) is a distinguished hallmark of cancer, and cancer stem cells (CSCs) contribute to this malignant characteristic. Therefore, it is of great significance to investigate and even...

    Authors: Runtian Wang, Kun Xu, Qin Chen, Qin Hu, Jian Zhang and Xiaoxiang Guan
    Citation: Journal of Translational Medicine 2023 21:409
  18. Insulin like growth factor II mRNA binding protein 3 (IGF2BP3) is an RNA binding protein with multiple roles in regulation of gene expression at the post-transcriptional level and is implicated in tumorigenesi...

    Authors: Feifei Yang, Qiang Ma, Bo Huang, Xiaolin Wang, Xiaojuan Pan, Ting Yu, Lingyu Ran, Shan Jiang, Haiping Li, Ye Chen, Yuying Liu, Ce Liang, Junwu Ren, Yuying Zhang, Shimin Wang, Wei Li…
    Citation: Journal of Translational Medicine 2023 21:402
  19. Bone marrow metastasis (BMM) is underestimated in gastric cancer (GC). GC with BMM frequently complicate critical hematological abnormalities like diffused intravascular coagulation and microangiopathic hemoly...

    Authors: Caiqin Wang, Bo Xie, Shi Yin, Jianghua Cao, Junhao Huang, Longyang Jin, Ge Du, Xiaohui Zhai, Rongqin Zhang, Shanshan Li, Taiyuan Cao, Hongen Yu, Xinjuan Fan, Zuli Yang, Junsheng Peng, Jian Xiao…
    Citation: Journal of Translational Medicine 2023 21:399
  20. Ovarian cancer (OC) has high mortality and poor prognosis for lacking of specific biomarkers and typical clinical symptoms in the early stage. CEBPG is an important regulator in tumor development, yet it is un...

    Authors: Xiaoqian Zhang, Xiaocui Zheng, Xiang Ying, Weiwei Xie, Yujia Yin and Xipeng Wang
    Citation: Journal of Translational Medicine 2023 21:334
  21. Pancreatic ductal adenocarcinoma (PDAC) has a low survival, its incidence is rising and little therapeutic improvements are expected in the near future. It has been observed that Epithelial-to-Mesenchymal tran...

    Authors: Jos van Pelt, Bob Meeusen, Rita Derua, Liesbeth Guffens, Eric Van Cutsem, Veerle Janssens and Chris Verslype
    Citation: Journal of Translational Medicine 2023 21:317
  22. Gallbladder cancer (GBC) is the most prevalent and invasive biliary tract malignancy. As a GTPase-activating protein, Neurofibromin 1 (NF1) is a tumor suppressor that negatively regulates the RAS signaling pat...

    Authors: Lingxiao Zhang, Lin Jiang, Ling Zeng, Zhaohui Jin, Xuanjia Dong, Yuhan Zhang, Litian Chen, Yijun Shu, Yingbin Liu and Ying Huang
    Citation: Journal of Translational Medicine 2023 21:306
  23. Metastatic prostate cancer (mPCa) has a poor prognosis with limited treatment options. The high mobility of tumor cells is the key driving characteristic of metastasis. However, the mechanism is complex and fa...

    Authors: Zean Li, Yiran Tao, Ze Gao, Shirong Peng, Yiming Lai, Kaiwen Li, Xu Chen and Hai Huang
    Citation: Journal of Translational Medicine 2023 21:303
  24. Epithelial-to-mesenchymal transition (EMT) and cancer stem-like cells (CSLCs) play crucial role in tumor metastasis and drug-resistance. Disheveled3 (DVL3) is involved in malignant behaviors of cancer. However...

    Authors: Zhengguang Li, Zhirong Yang, Wei Liu, Wanglong Zhu, Lan Yin, Zhenyu Han, Yu Xian, Jie Wen, Hualong Tang, Xinyue Lin, Yuhan Yang, Jingyi Wang and Kun Zhang
    Citation: Journal of Translational Medicine 2023 21:302
  25. Osteosarcoma is a type of bone cancer that predominantly affects young individuals, including children and adolescents. The disease progresses through heterogeneous genetic alterations, and patients often deve...

    Authors: Ravi Chauhan, Ashna Gupta, Lakshay Malhotra, Ajaz A. Bhat, Raj K. Pandita, Tariq Masoodi, Gunjan Dagar, Hana Q. Sadida, Sara K. Al-Marzooqi, Atul Batra, Sameer Bakhshi, Mehar Chand Sharma, Pranay Tanwar, Shah Alam Khan, Ethayathulla Abdul Samath, Shahab Uddin…
    Citation: Journal of Translational Medicine 2023 21:286
  26. The primary cilia (PC) is a microtubule-based and nonmotile organelle which protrudes from the surface of almost all mammalian cells. At present, PC has been found to be a deficiency or loss in multiple cancer...

    Authors: Jingxian Li, Yuanjiong Qi, Bo Li, Yan Liu, Kuo Yang, Zhihong Zhang, Jianqiang Zhu and E. Du
    Citation: Journal of Translational Medicine 2023 21:281
  27. Oral squamous cell carcinoma (OSCC), an HPV-negative head and neck cancer, frequently metastasizes to the regional lymph nodes but only occasionally beyond. Initial phases of metastasis are associated with an ...

    Authors: Kai Horny, Christoph Sproll, Lukas Peiffer, Frauke Furtmann, Patricia Gerhardt, Jan Gravemeyer, Nikolas H. Stoecklein, Ivelina Spassova and Jürgen C. Becker
    Citation: Journal of Translational Medicine 2023 21:267
  28. Metastasis, the leading cause of cancer-related death in patients diagnosed with ovarian cancer (OC), is a complex process that involves multiple biological effects. With the continuous development of sequenci...

    Authors: Jiahao Guo, Xiaoyang Han, Jie Li, Zhefeng Li, Junjie Yi, Yan Gao, Xiaoting Zhao and Wentao Yue
    Citation: Journal of Translational Medicine 2023 21:254
  29. Cancer-associated fibroblasts (CAFs), an important component of the tumor microenvironment (TME), play crucial roles in tumor stemness. It has been shown in various cancer studies that stanniocalcin-1 (STC1) i...

    Authors: Shuya Bai, Yuchong Zhao, Wei Chen, Wang Peng, Yun Wang, Si Xiong, Aruna, Yanling Li, Yilei Yang, Shiru Chen, Bin Cheng and Ronghua Wang
    Citation: Journal of Translational Medicine 2023 21:236
  30. The prognosis of pancreatic cancer patients remains relatively poor. Although some patients would receive surgical resection, distant metastasis frequently occurs within one year. Epithelial-mesenchymal transi...

    Authors: Yuanyang Wang, Cheng Qin, Bangbo Zhao, Zeru Li, Tianyu Li, Xiaoying Yang, Yutong Zhao and Weibin Wang
    Citation: Journal of Translational Medicine 2023 21:201
  31. The interaction between the tumor-microenvironment (TME) and the cancer cells has emerged as a key player in colorectal cancer (CRC) metastasis. A small proportion of CRC cells which undergo epithelial-mesench...

    Authors: Jinsen Zheng, Rongzhang Dou, Xinyao Zhang, Bo Zhong, Chenggang Fang, Qian Xu, Ziyang Di, Sihao Huang, Zaihuan Lin, Jialin Song, Shuyi Wang and Bin Xiong
    Citation: Journal of Translational Medicine 2023 21:153
  32. Cancer-testis antigens (CTAs) are often expressed in tumor and testicular tissues but not in other normal tissues. To date, there has been no comprehensive study of the expression and clinical significance of ...

    Authors: Yu Miao, Yosuke Konno, Baojin Wang, Lin Zhu, Tianyue Zhai, Kei Ihira, Noriko Kobayashi, Hidemichi Watari, Xin Jin, Junming Yue, Peixin Dong and Mingyan Fang
    Citation: Journal of Translational Medicine 2023 21:151
  33. Histone deacetylases (HDAC) contribute to oncogenic program, pointing to their inhibitors as a potential strategy against cancers. We, thus, studied the mechanism of HDAC inhibitor ITF2357 in resistance of mut...

    Authors: Jian Cui, Fei Xu, Wei Bai, Tiantian Zhao, Junbo Hong and Wei Zuo
    Citation: Journal of Translational Medicine 2023 21:125
  34. Metastasis is the predominant cause of mortality in patients with breast cancer. Long noncoding RNAs (lncRNAs) have been shown to drive important phenotypes in tumors, including invasion and metastasis. Howeve...

    Authors: Rong Guo, Yonghui Su, Qi Zhang, Bingqiu Xiu, Sheng Huang, Weiru Chi, Liyi Zhang, Lun Li, Jianjing Hou, Jia Wang, Jiajian Chen, Yayun Chi, Jingyan Xue and Jiong Wu
    Citation: Journal of Translational Medicine 2023 21:120
  35. The role of microRNA (miRNA) in modulating the function of cancer stem cells through diverse signaling pathway has been evidenced. We here identified a role of microRNA (miRNA) family, specifically miR-148/152...

    Authors: Xiaoying Li, Lin Li and Jiangying Wu
    Citation: Journal of Translational Medicine 2023 21:105
  36. Sirtuin 3 (Sirt3) is a controversial regulator of carcinogenesis. It residents in the mitochondria and gradually decays during aging. In this study, we tried to investigate the role of Sirt3 in carcinogenesis ...

    Authors: Liyi Wu, Xinyi Yan, Ruibo Sun, Ye Ma, Wanyu Yao, Baogui Gao, Qingyuan Zhang, Junxiong You, Hao Wang, Qinrui Han and Xuegang Sun
    Citation: Journal of Translational Medicine 2023 21:81
  37. Clear cell renal cell carcinoma (ccRCC) is a major worldwide health problem due to its high prevalence and mortality rate. A disintegrin and metalloproteinase 12 (ADAM12) is aberrantly expressed in various can...

    Authors: Jinming Xu, Yan Wang, Jiahao Jiang, Cong Yin and Bentao Shi
    Citation: Journal of Translational Medicine 2023 21:56
  38. Deterioration of normal intestinal epithelial cells is crucial for colorectal tumorigenesis. However, the process of epithelial cell deterioration and molecular networks that contribute to this process remain ...

    Authors: Xiaoqi Huang, Chongyin Han, Jiayuan Zhong, Jiaqi Hu, Yabin Jin, Qinqin Zhang, Wei Luo, Rui Liu and Fei Ling
    Citation: Journal of Translational Medicine 2023 21:45
  39. Esophageal squamous cell carcinoma (ESCC) is a deadly gastrointestinal malignancy, and chemotherapy resistance is a key factor leading to its poor prognosis. M2 tumor-associated macrophages (M2-TAMs) may be an...

    Authors: Kaige Yang, Yufang Xie, Lele Xue, Fanping Li, Chenghua Luo, Weihua Liang, Haijun Zhang, Ya Li, Yilin Ren, Mengmeng Zhao, Weinan Wang, Jia Liu, Xihua Shen, Wenhu Zhou, Jing Fei, Weigang Chen…
    Citation: Journal of Translational Medicine 2023 21:26
  40. Gastric cancer (GC) is the fifth most common cancer and the third most common cause of cancer death worldwide. Plant homeodomain (PHD)-finger domain protein PHF5A has been demonstrated to play a promoting role...

    Authors: Zhandong Zhang, Liangqun Peng, Wei Yang, Baodong Li, Yawei Hua and Suxia Luo
    Citation: Journal of Translational Medicine 2023 21:5
  41. Solid tumors are stiffer than their surrounding normal tissues; however, their interior stiffness is not uniform. Under certain conditions, cancer cells can acquire stem-like phenotypes. However, it remains un...

    Authors: Jiayun Wei, Jia Yao, Chendong Yang, Yongcui Mao, Dan Zhu, Ye Xie, Pinyan Liu, Mengchao Yan, Longfei Ren, Yan Lin, Qiuxia Zheng and Xun Li
    Citation: Journal of Translational Medicine 2022 20:555
  42. The tumour microenvironment and cirrhotic liver are excellent sources of cancer-associated fibroblasts (CAFs), which participate in carcinogenesis. Thus, it is important to clarify the crosstalk between CAFs a...

    Authors: Jungang Zhao, Rizhao Li, Jiacheng Li, Ziyan Chen, Zixia Lin, Baofu Zhang, Liming Deng, Gang Chen and Yi Wang
    Citation: Journal of Translational Medicine 2022 20:520
  43. Pancreatic cancer (PC) is a highly malignant tumor which threatens human’s health. Long non-coding RNAs (lncRNAs) are implicated in many cancers, including PC, but their mechanisms in PC have not yet been enti...

    Authors: Dandan Yu, Zhigang Zhao, Li Wang, Shishi Qiao, Zhen Yang, Qiang Wen and Guanghui Zhu
    Citation: Journal of Translational Medicine 2022 20:511
  44. Hepatocellular carcinoma (HCC) is one of the most common and malignant tumors in the digestive tract. Tumor Suppressor Candidate 3 (TUSC3) is one subunit of the endoplasmic reticulum Oligosaccharyl transferase...

    Authors: Ruxia Deng, Xiansheng Lu, Chang Hong, Rui Cai, Ping Wang, Le Xiong, Xiaoyu Wang, Qiaoyu Chen and Jie Lin
    Citation: Journal of Translational Medicine 2022 20:485
  45. Metastasis is the primary cause of cancer-related mortality. Metastasis involves a complex multistep process during which individual tumor cells spread primarily through destruction of the endothelial barrier,...

    Authors: Guoxin Zhang, Mengyuan Li, Dandan Zhou, Xingjiu Yang, Wenlong Zhang and Ran Gao
    Citation: Journal of Translational Medicine 2022 20:446
  46. Adrenocortical carcinoma (ACC) is an extremely rare, aggressive tumor with few effective therapeutic options or drugs. Mitotane (Mtn), which is the only authorized therapeutic drug, came out in 1970 and is sti...

    Authors: Liwen Ren, Yihui Yang, Wan Li, Xiangjin Zheng, Jinyi Liu, Sha Li, Hong Yang, Yizhi Zhang, Binbin Ge, Sen Zhang, Weiqi Fu, Dexin Dong, Guanhua Du and Jinhua Wang
    Citation: Journal of Translational Medicine 2022 20:444
  47. Gallbladder cancer (GBC) is a highly aggressive malignant cancer in the biliary system with poor prognosis. XPO1 (chromosome region maintenance 1 or CRM1) mediates the nuclear export of several proteins, mainl...

    Authors: Cheng Zhao, Zi-yi Yang, Jian Zhang, Ou Li, Shi-lei Liu, Chen Cai, Yi-jun Shu, Li-jia Pan, Wei Gong and Ping Dong
    Citation: Journal of Translational Medicine 2022 20:434
  48. Esophageal squamous cell carcinoma (ESCC) is one of the most severe cancers and is characterized by chemotherapy resistance and poor prognosis associated with epithelial-mesenchymal transition (EMT). In a prev...

    Authors: Yuto Kubo, Koji Tanaka, Yasunori Masuike, Tsuyoshi Takahashi, Kotaro Yamashita, Tomoki Makino, Takuro Saito, Kazuyoshi Yamamoto, Tomoyuki Tsujimoto, Takashi Harino, Yukinori Kurokawa, Makoto Yamasaki, Kiyokazu Nakajima, Hidetoshi Eguchi and Yuichiro Doki
    Citation: Journal of Translational Medicine 2022 20:383
  49. Osteosarcoma is one of the most malignant tumors, and it occurs mostly in children and adolescents. Currently, surgery and chemotherapy are the main treatments. The recurrence rate is high and the prognosis is...

    Authors: Wenhao Chen, Yuxiang Lin, Meichen Jiang, Qingshui Wang and Qiang Shu
    Citation: Journal of Translational Medicine 2022 20:355
  50. PolyC-RNA-binding protein 1 (PCBP1) functions as a tumour suppressor and RNA regulator that is downregulated in human cancers. Here, we aimed to reveal the biological function of PCBP1 in lung adenocarcinoma (...

    Authors: Yujia Zheng, Zheng Zhou, Ran Wei, Chu Xiao, Hao Zhang, Tao Fan, Bo Zheng, Chunxiang Li and Jie He
    Citation: Journal of Translational Medicine 2022 20:343