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Translational Cancer Biology

Section edited by Cristina Maccalli

This section aims to provide a platform for the communication and dissemination of advances in cancer biology and their translational applications. Studies considered for publication include those dissecting the mechanisms of transformation, progression and metastatization, the biology of cancer stem cells and their immunological properties, the mechanisms undergoing the epithelial-to mesenchymal (EMT) transition and tumor dormancy, their relationship with immune functions and the mechanisms undergoing cancer resistance to therapies. 

This section is also dedicated to those investigations dedicated to the translational aspects and the development of novel therapies related to the aforementioned themes and the identification of patient’s responsiveness and outcome to therapies.

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  1. CD155 is a transmembrane protein that inhibits antitumor immune response and represents a predictor of worse prognosis in non-small-cell lung cancer (NSCLC). However, it remains unexplored its association with...

    Authors: Popa-Navarro Xitlally, Avilés-Salas Alejandro, Hernández-Pedro Norma, Orozco-Morales Mario, Caballé-Pérez Enrique, Castillo-Ruiz Cesar, Lucio-Lozada José, Barrios-Bernal Pedro, Hernandez-Martinez Juan-Manuel and Arrieta Oscar
    Citation: Journal of Translational Medicine 2024 22:841
    Content type: Research Published on:

  2. The roles of the transcriptional factor SIX2 have been identified in several tumors. However, its roles in gastric cancer (GC) progression have not yet been revealed. Our objective is to explore the impact and...

    Authors: Qianqian Guo, Yi Zhou, Haiwei Ni, Miaomiao Niu, Shengtao Xu, Lufeng Zheng and Wenzhou Zhang
    Citation: Journal of Translational Medicine 2024 22:832
    Content type: Research Published on:

  3. Circulating tumor cells (CTCs) are pivotal in tumor metastasis across cancers, yet their specific role in renal cancer remains unclear.

    Authors: Yibing Guan, Xueyi Liu, Juanhua Tian, Guang Yang, Fangshi Xu, Ni Guo, Lingyu Guo, Ziyan Wan, Zhixin Huang, Mei Gao and Tie Chong
    Citation: Journal of Translational Medicine 2024 22:817
    Content type: Research Published on:

  4. Recycling of integrin via endosomal vesicles is critical for the migration of cancer cells, which leads to the metastasis of pancreatic cancer and devastating cancer-related death. So, new diagnostic and thera...

    Authors: Van-Thanh Duong, Mihyang Ha, Jayoung Kim, Ji-Young Kim, Siyoung Park, Khatun Mst Reshma, Myoung-Eun Han, Dongjun Lee, Yun Hak Kim and Sae-Ock Oh
    Citation: Journal of Translational Medicine 2024 22:800
    Content type: Research Published on:

  5. We have previously demonstrated the significant reliance of pancreatic Cancer Stem Cells (PaCSCs) on mitochondrial oxidative phosphorylation (OXPHOS), which enables versatile substrate utilization, including f...

    Authors: Marta Mascaraque, Sarah Courtois, Alba Royo-García, David Barneda, Andrei M. Stoian, Isabel Villaoslada, Pilar Espiau-Romera, Ansooya Bokil, Andrés Cano-Galiano, Petra Jagust, Christopher Heeschen and Patricia Sancho
    Citation: Journal of Translational Medicine 2024 22:797
    Content type: Research Published on:

  6. Naïve CD4+ T cells and their differentiated counterparts play a significant regulatory role in the tumor immune microenvironment, yet their effects on lung adenocarcinoma (LUAD) are not fully understood.

    Authors: Runze Liu, Guangjian Yang, Hongbo Guo, Feihu Chen, Shuangqing Lu and Hui Zhu
    Citation: Journal of Translational Medicine 2024 22:781
    Content type: Research Published on:

  7. The Clustered Regularly Interspaced Short Palindromic Repeat (CRISPR)/Cas9 system, a groundbreaking innovation in genetic engineering, has revolutionized our approach to surmounting complex diseases, culminati...

    Authors: Tianye Li, Shuiquan Li, Yue Kang, Jianwei Zhou and Ming Yi
    Citation: Journal of Translational Medicine 2024 22:749
    Content type: Review Published on:

  8. Human epidermal growth factor receptor 2-positive (HER2+) breast cancer (BC), which accounts for approximately one-fifth of all BCs, are highly invasive with a high rate of recurrence and a poor prognosis. Sev...

    Authors: Gang Wang, Yuanli Wu, Yue Su, Na Qu, Bo Chen, Duanfang Zhou, Lie Yuan, Manjialan Yin, Mingpu Liu and Weiying Zhou
    Citation: Journal of Translational Medicine 2024 22:745
    Content type: Research Published on:

  9. Although there has been some progress in the treatment of primary uveal melanoma (UVM), distant metastasis remains the leading cause of death in patients. Monitoring, staging, and treatment of metastatic disea...

    Authors: Yifang Sun, Jian Wu, Qian Zhang, Pengzhen Wang, Jinglin Zhang and Yonggang Yuan
    Citation: Journal of Translational Medicine 2024 22:695
    Content type: Research Published on:

  10. Lung cancer stands as the second most prevalent malignant neoplasm worldwide. Addressing the underlying mechanisms propelling the progression of non-small cell lung cancer is of paramount importance. In this s...

    Authors: Yiru Kong, Rongrong Jiang, Hui Zhou, Mengxi Ge, Hao Lin, Yu Wang, Rongrong Yao, Qing Wang, Xiaohua Liang, Jing Li and Xinli Zhou
    Citation: Journal of Translational Medicine 2024 22:689
    Content type: Research Published on:

  12. This study aims to elucidate the functional role of IQGAP1 phosphorylation modification mediated by the SOX4/MAPK1 regulatory axis in developing pancreatic cancer through phosphoproteomics analysis.

    Authors: Chao Song, Ganggang Wang, Mengmeng Liu, Siyang Han, Meiyuan Dong, Maozhen Peng, Wenquan Wang, Yicun Wang, Yaolin Xu and Liang Liu
    Citation: Journal of Translational Medicine 2024 22:602
    Content type: Research Published on:

  13. Wnt/β-catenin signaling is a critical pathway that influences development and therapeutic response of non-small cell lung cancer (NSCLC). In recent years, many Wnt regulators, including proteins, miRNAs, lncRN...

    Authors: Zixu Zhang, David Westover, Zhantong Tang, Yue Liu, Jinghan Sun, Yunxi Sun, Runqing Zhang, Xingyue Wang, Shihui Zhou, Nigaerayi Hesilaiti, Qi Xia and Zhenfang Du
    Citation: Journal of Translational Medicine 2024 22:565
    Content type: Review Published on:

  14. The poor chemo-response and high DNA methylation of ovarian clear cell carcinoma (OCCC) have attracted extensive attentions. Recently, we revealed the mutational landscape of the human kinome and additional ca...

    Authors: Shang Li, Gert Jan Meersma, Jolanta Kupryjanczyk, Steven de Jong and G. Bea A. Wisman
    Citation: Journal of Translational Medicine 2024 22:556
    Content type: Research Published on:

  15. Hepatocellular carcinoma (HCC) is a common malignant tumor, and glutamine is vital for tumor cells. The role of glutamine transporter SLC1A5 in tumor progression and transarterial chemoembolization (TACE) effi...

    Authors: Guixiong Zhang, Yitai Xiao, Jizhou Tan, Hang Liu, Wenzhe Fan and Jiaping Li
    Citation: Journal of Translational Medicine 2024 22:543
    Content type: Research Published on:

  16. The adaptability of glioblastoma (GBM) cells, encouraged by complex interactions with the tumour microenvironment (TME), currently renders GBM an incurable cancer. Despite intensive research, with many clinica...

    Authors: Jasmine White, Madeleine P. J. White, Agadha Wickremesekera, Lifeng Peng and Clint Gray
    Citation: Journal of Translational Medicine 2024 22:540
    Content type: Review Published on:

  17. Accumulating evidence indicated that HHEX participated in the initiation and development of several cancers, but the potential roles and mechanisms of HHEX in hepatocellular carcinoma (HCC) were largely unclea...

    Authors: Huizi Li, Jin Liu, Jie Lai, Xinyao Su, Xiaofeng Wang, Jiaqing Cao, Shengxun Mao, Tong Zhang and Qiuping Gu
    Citation: Journal of Translational Medicine 2024 22:537
    Content type: Research Published on:

  18. Cancer stem-like cells (CSCs) have been extensively researched as the primary drivers of therapy resistance and tumor relapse in patients with breast cancer. However, due to lack of specific molecular markers,...

    Authors: Oana Baldasici, Olga Soritau, Andrei Roman, Carmen Lisencu, Simona Visan, Laura Maja, Bogdan Pop, Bogdan Fetica, Andrei Cismaru, Laurian Vlase, Loredana Balacescu, Ovidiu Balacescu, Aman Russom and Oana Tudoran
    Citation: Journal of Translational Medicine 2024 22:530
    Content type: Research Published on:

  20. Cartilage oligomeric matrix protein (COMP), an extracellular matrix glycoprotein, is vital in preserving cartilage integrity. Further, its overexpression is associated with the aggressiveness of several types ...

    Authors: Gilar Gorji-Bahri, B. Madhu Krishna, Catharina Hagerling, Akira Orimo, Karin Jirström, Konstantinos S. Papadakos and Anna M. Blom
    Citation: Journal of Translational Medicine 2024 22:351
    Content type: Research Published on:

  21. THOC7-AS1 and FSTL1 expression are frequently upregulated in cutaneous squamous cell carcinoma (cSCC). However, their molecular biological mechanisms remain elusive and their potential as therapeutic targets n...

    Authors: Site Yu, Xu Cui, Situo Zhou, Yun Li, Wenjie Feng, Xiangjun Zhang, Yuhui Zhong and Pihong Zhang
    Citation: Journal of Translational Medicine 2024 22:347
    Content type: Research Published on:

  22. This study aimed to assess the functions of cell division cycle protein 45 (CDC45) in Non-small cell lung cancer (NSCLC) cancer and its effects on stemness and metastasis.

    Authors: Yafeng Liu, Tao Han, Zhi Xu, Jing Wu, Jiawei Zhou, Jianqiang Guo, Rui Miao, Yingru Xing, Deyong Ge, Ying Bai and Dong Hu
    Citation: Journal of Translational Medicine 2024 22:335
    Content type: Research Published on:

  23. The progression of gallbladder cancer (GBC) is accompanied by abnormal fatty acid β-oxidation (FAO) metabolism. Different types of lipids perform various biological functions. This study aimed to determine the...

    Authors: Yang Yang, Huaifeng Li, Ke Liu, Lu Zou, Shanshan Xiang, Yajun Geng, Xuechuan Li, Shimei Qiu, Jiahua Yang, Xuya Cui, Lin li, Yang Li, Weijian Li, Siyuan Yan, Liguo Liu, Xiangsong Wu…
    Citation: Journal of Translational Medicine 2024 22:299
    Content type: Research Published on:

  24. Lipid metabolism is widely reprogrammed in tumor cells. Lipid droplet is a common organelle existing in most mammal cells, and its complex and dynamic functions in maintaining redox and metabolic balance, regu...

    Authors: Boer Deng, Weimin Kong, Xiaochang Shen, Chao Han, Ziyi Zhao, Shuning Chen, Chunxiao Zhou and Victoria Bae-Jump
    Citation: Journal of Translational Medicine 2024 22:290
    Content type: Review Published on:

  25. Although hepatitis B virus (HBV) infection is a major risk factor for hepatic cancer, the majority of HBV carriers do not develop this lethal disease. Additional molecular alterations are thus implicated in th...

    Authors: Fuqiang Huang, Jing Guo, Na Zhao, Mengjie Hou, Xiaochen Gai, Shuhui Yang, Pei Cai, Yanan Wang, Qian Ma, Qi Zhao, Li Li, Huayu Yang, Yanling Jing, Di Jin, Zhongdong Hu, Xiaojun Zha…
    Citation: Journal of Translational Medicine 2024 22:254
    Content type: Research Published on:

  26. Human discs large-associated protein 5 (DLGAP5) is reported to play a pivotal role in regulating the cell cycle and implicate in tumorigenesis and progression of various cancers. Our current research endeavore...

    Authors: Maojian Chen, Shaoping Zhang, Fan Wang, Junyi He, Wei Jiang and Li Zhang
    Citation: Journal of Translational Medicine 2024 22:209
    Content type: Research Published on:

  27. DNMT3L is a crucial DNA methylation regulatory factor, yet its function and mechanism in hepatocellular carcinoma (HCC) remain poorly understood. Bioinformatics-based big data analysis has increasingly gained ...

    Authors: Xiaokai Yan, Yao Qi, Xinyue Yao, Nanjing Zhou, Xinxin Ye and Xing Chen
    Citation: Journal of Translational Medicine 2024 22:128
    Content type: Research Published on:

  28. Malignant progression is the major cause of poor prognosis in breast cancer (BC) patients. Plasma exosomal miRNAs have been reported to be involved in tumor progression, but their roles in BC remain unclear.

    Authors: Yao Li, Lei Fan, An Yan, Xiaotian Ren, Yanyang Zhao and Bin Hua
    Citation: Journal of Translational Medicine 2024 22:112
    Content type: Research Published on:

  29. Cancer stem cells (CSCs) are a small population of cells in tumor tissues that can drive tumor initiation and promote tumor progression. A small number of previous studies indirectly mentioned the role of F-bo...

    Authors: Guodong Xiao, Weiping Lu, Jing Yuan, Zuyue Liu, Peili Wang and Huijie Fan
    Citation: Journal of Translational Medicine 2024 22:99
    Content type: Research Published on:

  30. Prostate cancer (PCa) is the second leading cause of cancer-related mortality among men worldwide, and its incidence has risen substantially in recent years. Therefore, there is an urgent need to identify nove...

    Authors: Enchong Zhang, Zhengjie Chen, Wangmin Liu, Lin Lin, Lina Wu, Johnny Guan, Jianfeng Wang, Chuize Kong, Jianbin Bi and Mo Zhang
    Citation: Journal of Translational Medicine 2024 22:12
    Content type: Research Published on:

  32. Tandem C2 domains, nuclear (TC2N) is a C2 domain-containing protein that belongs to the carboxyl-terminal type (C-type) tandem C2 protein family, and acts as an oncogenic driver in several cancers. Previously,...

    Authors: Xiang-lin Hao, Yang-fan Lv, De-feng Li, Fu-hai Bai, Ji Gong, Guang-qiang Pan, Lin-xi Su, Ya-li Wang, Wan-lei Fu, Bo Liu, Lu Huang, Dong Yan, Qiu-lin Tan, Jin-yi Liu and Qiao-nan Guo
    Citation: Journal of Translational Medicine 2024 22:6
    Content type: Research Published on:

  33. Mutations in TP53 gene is considered a main driver of hepatocellular carcinoma (HCC). While TP53 mutations are the leading cause of p53 dysfunction, their occurrence rates may drop to approximately 10% in cohorts...

    Authors: Chun Wang, Hui Kang, Yun Yi, Yang Ding, Fan Wang, Jie Luo, Mingliang Ye, Yinghui Hong, Chao Xia, Junwei Yan, Lan Liu, Jing Liu, Zibiao Zhong, Zhonglin Zhang, Qiu Zhao and Ying Chang
    Citation: Journal of Translational Medicine 2023 21:919
    Content type: Research Published on:

  34. Pancreatic cancer is an aggressive malignancy with high mortality, and cancer cell stemness and related drug resistance are considered important contributors to its poor prognosis. The objective of this study ...

    Authors: Xiao-hui Li, Gui-zhong Huang, Zi-lan Xu, Chong-yu Zhao, Xiao-yuan Dong, Bo-kang Cui and Xiao-jun Lin
    Citation: Journal of Translational Medicine 2023 21:911
    Content type: Research Published on:

  35. The occurrence of epithelial-mesenchymal transition (EMT) and immune evasion is considered to contribute to poor prognosis in lung adenocarcinoma (LUAD). Therefore, this study aims to explore the key oncogenes...

    Authors: Yafeng Liu, Tao Han, Jing Wu, Jiawei Zhou, Jianqiang Guo, Rui Miao, Zhi Xu, Yingru Xing, Ying Bai and Dong Hu
    Citation: Journal of Translational Medicine 2023 21:909
    Content type: Research Published on:

  36. Complement component 3a and its receptor (C3a/C3aR) and the nucleotide-binding oligomerization domain-like receptor protein-3 (NLRP3) inflammasome contribute to epithelial-mesenchymal transition (EMT). However...

    Authors: Danyu You, Kun Nie, Xiaoting Wu, Mengjie Weng, Liyan Yang, Yi Chen, Jiong Cui and Jianxin Wan
    Citation: Journal of Translational Medicine 2023 21:904
    Content type: Research Published on:

  37. Ovarian cancer is the leading cause of death from gynecologic illnesses worldwide. High-grade serous ovarian cancer (HGSOC) is a gynecological tumor that accounts for roughly 70% of ovarian cancer deaths in wo...

    Authors: Yuanzhi Chen, Zhicheng He, Shuting Yang, Cheng Chen, Wenyong Xiong, YingYing He and Shubai Liu
    Citation: Journal of Translational Medicine 2023 21:886
    Content type: Research Published on:

  38. Sine oculis homeobox homolog 1 (SIX1) is a transcription factor that has recently been identified as a crucial regulator of embryonic development and tumorigenesis. SIX1 is upregulated in different types of tu...

    Authors: Liantao Guo, Faminzi Li, Hanqing Liu, Deguang Kong, Chuang Chen and Shengrong Sun
    Citation: Journal of Translational Medicine 2023 21:866
    Content type: Research Published on:

  39. Glioblastoma, the most common primary malignant tumor of the brain, is associated with poor prognosis. Glioblastoma cells exhibit high proliferative and invasive properties, and glioblastoma stem cells (GSCs) ...

    Authors: Zhiyuan Liu, Songtao Wang, Kuo Yu, Kaile Chen, Liang Zhao, Jiayue Zhang, Kexiang Dai and Peng Zhao
    Citation: Journal of Translational Medicine 2023 21:863
    Content type: Research Published on:

  40. N6-methyladenosine (m6A) is the most prevalent RNA modification. Although hnRNPA2B1, as a reader of m6A modification, has been reported to promote tumorigenesis in a few types of tumors, its role in hepatocell...

    Authors: Weijie Hao, Zhimin Chen, Jingzhi Tang, Ru Yang, Wei-Qiang Gao and Huiming Xu
    Citation: Journal of Translational Medicine 2023 21:861
    Content type: Research Published on:

  41. Anaplastic thyroid carcinoma (ATC) is a deadly disease with a poor prognosis. Thus, there is a pressing need to determine the mechanism of ATC progression. The homeobox D9 (HOXD9) transcription factor has been...

    Authors: Yong Zhong, Fan Yu, Ling Yang, Yu Wang, Lin Liu, Chengyou Jia, Haidong Cai, Jianshe Yang, Shiyang Sheng, Zhongwei Lv, Li Weng, Bo Wu and Xiaoping Zhang
    Citation: Journal of Translational Medicine 2023 21:817
    Content type: Research Published on:

  42. The occurrence and progression of tumors can be established through a complex interplay among tumor cells undergoing epithelial-mesenchymal transition (EMT), invasive factors and immune cells. In this study, w...

    Authors: Muhong Wang, Chunyu Deng, Cheng Yang, Mingze Yan, Haibo Lu, Yan Zhang, Honghao Liu, Zhekuan Tong, Jiaao Ma, Jiaming Wang, Yan Zhang, Jiahao Wang, Yuhong Xuan, Haiyue Cheng, Kai Zhao, Jiaqi Zhang…
    Citation: Journal of Translational Medicine 2023 21:794
    Content type: Research Published on:

  43. Prostate cancer (PCA) is the fifth leading cause of cancer-related deaths worldwide, with limited treatment options in the advanced stages. The immunosuppressive tumor microenvironment (TME) of PCA results in ...

    Authors: Kun Zheng, Youlong Hai, Yue Xi, Yukun Zhang, Zheqi Liu, Wantao Chen, Xiaoyong Hu, Xin Zou and Jie Hao
    Citation: Journal of Translational Medicine 2023 21:789
    Content type: Research Published on:

  44. Gastric cancer (GC) ranks as the fifth most common cancer worldwide and is characterized by its significant heterogeneity and unfavorable prognosis. Thus, identifying efficient prognostic factors and understan...

    Authors: Fangyuan Qi, Yaru Wang, Bingxin Yu and Fan Li
    Citation: Journal of Translational Medicine 2023 21:766
    Content type: Research Published on:

  45. Triple-negative breast cancer (TNBC) development may be associated with tumor immune escape. This study explores whether the CHI3L1/MAF/CTLA4/S100A4 axis affects immune escape in TNBC through interplay with tr...

    Authors: Shufeng Ji, Hao Yu, Dan Zhou, Xulong Fan, Yan Duan, Yijiang Tan, Min Lang and Guoli Shao
    Citation: Journal of Translational Medicine 2023 21:721
    Content type: Research Published on:

  46. Polyploid giant cancer cells (PGCCs), a specific type of cancer stem cells (CSCs), can be induced by hypoxic microenvironments, chemical reagents, radiotherapy, and Chinese herbal medicine. Moreover, PGCCs can...

    Authors: Linlin Fan, Minying Zheng, Xinyue Zhou, Yongjun Yu, Yidi Ning, Wenzheng Fu, Jing Xu and Shiwu Zhang
    Citation: Journal of Translational Medicine 2023 21:719
    Content type: Research Published on:

  47. Cancer stem cells (CSCs) have emerged as key contributors to tumor initiation, growth, and metastasis. In addition, CSCs play a significant role in inducing immune evasion, thereby compromising the effectivene...

    Authors: Yan-Ruide Li, Ying Fang, Zibai Lyu, Yichen Zhu and Lili Yang
    Citation: Journal of Translational Medicine 2023 21:686
    Content type: Review Published on:

  48. Gastric cancer (GC) is a fatal cancer with unclear pathogenesis. In this study, we explored the function and potential mechanisms of intercellular adhesion molecule 2 (ICAM2) in the development and advancement...

    Authors: Xiaocheng Tang, Jintuan Huang, Yingming Jiang, Jun Qiu, Tuoyang Li, Weiyao Li, Zijian Chen, Zhenze Huang, Xihu Yu, Tao Yang, Xiang Ji, Rongchang Tan, Li lv, Zuli Yang and Hao Chen
    Citation: Journal of Translational Medicine 2023 21:670
    Content type: Research Published on:

  49. Ladinin-1 (LAD1), an anchoring filament protein, has been associated with several cancer types, including cancers of the colon, lungs, and breast. However, it is still unclear how and why LAD1 causes gastric c...

    Authors: Yingming Jiang, Yanchun Feng, Jintuan Huang, Zhenze Huang, Rongchang Tan, Tuoyang Li, Zijian Chen, Xiaocheng Tang, Jun Qiu, Chujun Li, Hao Chen and Zuli Yang
    Citation: Journal of Translational Medicine 2023 21:632
    Content type: Research Published on:

  50. Increasing evidence suggests that hepatocellular carcinoma (HCC) stem cells (LCSCs) play an essential part in HCC recurrence, metastasis, and chemotherapy and radiotherapy resistance. Multiple studies have dem...

    Authors: Rui Liang, Weifeng Hong, Yang Zhang, Di Ma, Jinwei Li, Yisong Shi, Qing Luo, Shisuo Du and Guanbin Song
    Citation: Journal of Translational Medicine 2023 21:631
    Content type: Research Published on:

Journal of Translational Medicine

ISSN: 1479-5876

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