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Translational cancer biology

Section edited by Cristina Maccalli

This section aims to provide a platform for the communication and dissemination of advances in cancer biology and their translational applications. Studies considered for publication include those dissecting the mechanisms of transformation, progression and metastatization, the biology of cancer stem cells and their immunological properties, the mechanisms undergoing the epithelial-to mesenchymal (EMT) transition and tumor dormancy, their relationship with immune functions and the mechanisms undergoing cancer resistance to therapies. 

This section is also dedicated to those investigations dedicated to the translational aspects and the development of novel therapies related to the aforementioned themes and the identification of patient’s responsiveness and outcome to therapies.

  1. Cancer stem cells (CSCs) are key regulators in the processes of tumor initiation, progression, and recurrence. The mechanism that maintains their stemness remains enigmatic, although the role of several long n...

    Authors: Yu-Shui Ma, Xiao-Li Yang, Yu-Shan Liu, Hua Ding, Jian-Jun Wu, Yi Shi, Cheng-You Jia, Gai-Xia Lu, Dan-Dan Zhang, Hui-Min Wang, Pei-Yao Wang, Fei Yu, Zhong-Wei Lv, Gao-Ren Wang, Ji-Bin Liu and Da Fu

    Citation: Journal of Translational Medicine 2021 19:400

    Content type: Research

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  2. EMT is an important biological process in the mechanism of tumor invasion and metastasis. However, there are still many unknowns about the specific mechanism of EMT in tumor. At present, a comprehensive analys...

    Authors: Yang Yang, Mingyang Feng, LiangLiang Bai, Weiting Liao, Kexun Zhou, Mengxi Zhang, Qiuji Wu, Feng Wen, Wanting Lei, Pengfei Zhang, Nan Zhang, Jiaxing Huang and Qiu Li

    Citation: Journal of Translational Medicine 2021 19:391

    Content type: Research

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  3. The recurrence and metastasis of nasopharyngeal cancer (NPC) may be mainly attributed to the persistence of cancer stem cells (CSCs); however, the linkage mechanism has yet to be fully elucidated.

    Authors: Mengyang Zhao, Zibo Tang, Yijun Wang, Jiaojiao Ding, Ying Guo and Tianhui Gao

    Citation: Journal of Translational Medicine 2021 19:387

    Content type: Research

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  4. Ubiquitin-conjugating enzyme E2T (UBE2T) acts as an oncogene in various types of cancer. However, the mechanisms behind its oncogenic role remain unclear in lung cancer. This study aims to explore the function...

    Authors: Jinhong Zhu, Haijiao Ao, Mingdong Liu, Kui Cao and Jianqun Ma

    Citation: Journal of Translational Medicine 2021 19:374

    Content type: Research

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  5. Although the rapid development of diagnosis and treatment has improved prognosis in early breast cancer, challenges from different therapeutic response remain due to breast cancer heterogeneity. DEAD-box helic...

    Authors: Shan Li, Jinfei Ma, Ang Zheng, Xinyue Song, Si Chen and Feng Jin

    Citation: Journal of Translational Medicine 2021 19:334

    Content type: Research

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  6. Pancreatic cancer (PC) is one of the most fatal digestive system cancers. tripartite motif-29 (TRIM29) has been reported as oncogene in several human cancers. However, the precise role and underlying signal ca...

    Authors: Xueqiang Deng, Xiaowei Fu, Hong Teng, Lu Fang, Bo Liang, Rengui Zeng, Lian Chen and Yeqing Zou

    Citation: Journal of Translational Medicine 2021 19:332

    Content type: Research

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  7. Circular RNA (circRNA) has been demonstrated to participate in cervical cancer development. In this study, we analyzed the role of hsa_circ_0000520 in cervical cancer.

    Authors: Qingling Zheng, Jin Zhang, Ting Zhang, Yanxiang Liu, Xiuluan Du, Xin Dai and Donghua Gu

    Citation: Journal of Translational Medicine 2021 19:314

    Content type: Research

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  8. Colorectal cancer (CRC) is a common malignant tumour of the digestive tract that is characterized by high patient morbidity and mortality rates. Claudin-7 (Cldn7), a tight junction protein, was recently report...

    Authors: Chang Xu, Yu-han Ding, Kun Wang, Mengdi Hao, Huimin Li and Lei Ding

    Citation: Journal of Translational Medicine 2021 19:311

    Content type: Research

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  9. Metastasis and invasion are crucial in determining the mortality of cervical carcinoma (CC) patients. The epithelial–mesenchymal transition (EMT) is now a universal explanation for the mechanisms of tumor meta...

    Authors: Haoqi Zhao, Lan Wang, Shufang Wang, Xihua Chen, Min Liang, Xin Zhang, Jiedong Wang and Xiangbo Xu

    Citation: Journal of Translational Medicine 2021 19:295

    Content type: Research

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  10. Colorectal cancer is the third most common diagnosis. Oxaliplatin is used as first-line treatment of colon cancer. However, oxaliplatin resistance greatly reduces its therapeutic effect. SRPK1 involves in pre-...

    Authors: Jing-Qiang Huang, He-Feng Li, Jing Zhu, Jun-Wei Song, Xian-Bin Zhang, Peng Gong, Qiu-Yu Liu, Chun-Hui Zhou, Liang Wang and Li-Yun Gong

    Citation: Journal of Translational Medicine 2021 19:280

    Content type: Research

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  11. Intratumour heterogeneous gene expression among cancer and cancer stem cells (CSCs) can cause failure of current targeted therapies because each drug aims to target the function of a single gene. Long mononucl...

    Authors: Narumol Bhummaphan, Piyapat Pin-on, Preeyaporn Plaimee Phiboonchaiyanan, Jirattha Siriluksana, Chatchawit Aporntewan, Pithi Chanvorachote and Apiwat Mutirangura

    Citation: Journal of Translational Medicine 2021 19:231

    Content type: Research

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  12. There is growing evidence discussing the role of long non-coding RNAs (lncRNAs) in cervical cancer (CC). We performed this study to explore the impact of exosomal lncRNA urothelial cancer-associated 1 (UCA1) i...

    Authors: Zhihui Gao, Qianqing Wang, Mei Ji, Xiangcui Guo, Li Li and Xiaoke Su

    Citation: Journal of Translational Medicine 2021 19:229

    Content type: Research

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  13. It has been established that microRNA (miR)-449a is anti-tumorigenic in cancers, including lung cancer. Therefore, this study further explored miR-449a-mediated mechanism in lung cancer, mainly focusing on lys...

    Authors: Shan Hu, Peng Cao, Kangle Kong, Peng Han, Yu Deng, Fan Li and Bo Zhao

    Citation: Journal of Translational Medicine 2021 19:224

    Content type: Research

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  14. Generally, cancer cells undergo metabolic reprogramming to adapt to energetic and biosynthetic requirements that support their uncontrolled proliferation. However, the mutual relationship between two critical ...

    Authors: Guoshu Bi, Yunyi Bian, Jiaqi Liang, Jiacheng Yin, Runmei Li, Mengnan Zhao, Yiwei Huang, Tao Lu, Cheng Zhan, Hong Fan and Qun Wang

    Citation: Journal of Translational Medicine 2021 19:219

    Content type: Research

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  15. Eukaryotic translation initiation factor 6 (eIF6) has a crucial function in the maturation of 60S ribosomal subunits, and it controls the initiation of protein translation. Although emerging studies indicate t...

    Authors: Liping Sun, Shuguang Liu, Xiaopai Wang, Xuefeng Zheng, Ya Chen and Hong Shen

    Citation: Journal of Translational Medicine 2021 19:216

    Content type: Research

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  16. As a significant cause of malignancy mortality, gastric carcinoma (GC) has been well documented to be an often-fatal diagnosis. Despite the limitations of effective therapy, immunotherapy has emerged as a prom...

    Authors: Qianmei Fu, Xiaohong Tan, Huaming Tang and Jijiang Liu

    Citation: Journal of Translational Medicine 2021 19:210

    Content type: Research

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  17. Clear cell renal cell carcinoma (ccRCC) is the most common and aggressive type of renal malignancy. Methyltransferase like 13 (METTL13) functions as an oncogene in most of human cancers, but its function and m...

    Authors: Zhuonan Liu, Tianshui Sun, Chiyuan Piao, Zhe Zhang and Chuize Kong

    Citation: Journal of Translational Medicine 2021 19:209

    Content type: Research

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  18. Tumor metastasis is the main cause of death of cancer patients, and cancer stem cells (CSCs) is the basis of tumor metastasis. However, systematic analysis of the stemness of prostate cancer cells is still not...

    Authors: Zao Dai and Ping Liu

    Citation: Journal of Translational Medicine 2021 19:206

    Content type: Research

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  19. Lung cancer is one of the most widely spread cancers in the world and half of the non-small cell lung cancers are lung adenocarcinoma (LUAD). Although there were several drugs been approved for LUAD therapy, a...

    Authors: Guangyan Kan, Ziyang Wang, Chunjie Sheng, Chen Yao, Yizhi Mao and Shuai Chen

    Citation: Journal of Translational Medicine 2021 19:161

    Content type: Research

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  20. CKLF like MARVEL transmembrane domain containing 6 (CMTM6) has been associated with the development in many kinds of cancers. However, the roles of CMTM6 in hepatocellular carcinoma (HCC) are largely unknown. ...

    Authors: Xiaoting Huang, Leyang Xiang, Baiyao Wang, Jijie Hu, Chunshan Liu, Anbang Ren, Kunpeng Du, Gengtai Ye, Yingying Liang, Yunqiang Tang, Dinghua Yang and Yawei Yuan

    Citation: Journal of Translational Medicine 2021 19:120

    Content type: Research

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  21. Glucose-regulating protein 78 (GRP78) is a molecular chaperone in the endoplasmic reticulum (ER) that promotes folding and assembly of proteins, controls the quality of proteins, and regulates ER stress signal...

    Authors: Shengkai Xia, Wenzhe Duan, Wenwen Liu, Xinri Zhang and Qi Wang

    Citation: Journal of Translational Medicine 2021 19:118

    Content type: Review

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  22. Bladder cancer (BCa) is a common malignancy characterized by high heterogeneity, yet the current treatment modalities are limited. The aim of the present investigation was to unravel the functional role of Kar...

    Authors: Fanchang Zeng, Liumei Luo, Daoyuan Li, Juncheng Guo and Min Guo

    Citation: Journal of Translational Medicine 2021 19:112

    Content type: Research

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  23. Ovarian cancer (OV) is the deadliest gynecological cancer. Transmembrane protein 119 (TMEM119) has been reported as oncogene in several human cancers. However, the function of TMEM119 in OV is still poorly known.

    Authors: Tianshui Sun, Fangfang Bi, Zhuonan Liu and Qing Yang

    Citation: Journal of Translational Medicine 2021 19:111

    Content type: Research

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  24. As a significant cause of cancer deaths worldwide, breast cancer continues to be a troublesome malignancy. Long non-coding RNAs (lncRNAs) have been implicated in the development of breast cancer. Abnormal meth...

    Authors: Aixia Hu, Fan Hong, Daohong Li, Yuwei Jin, Lingfei Kon, Ziguang Xu, Hui He and Qi Xie

    Citation: Journal of Translational Medicine 2021 19:95

    Content type: Research

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  25. Nasopharyngeal carcinoma (NPC) is one of the most common malignancy in head and neck. With the development of treatments, the prognosis has improved these years, but metastasis is still the main cause of treat...

    Authors: Hui Tian, Si Shi, Bo You, Qicheng Zhang, Miao Gu and Yiwen You

    Citation: Journal of Translational Medicine 2021 19:77

    Content type: Research

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  26. Studies of molecular mechanisms underlying tumor cell signaling highlighted a critical role for kinases in carcinogenesis and cancer progression. To this regard, protein kinases regulates a number of critical ...

    Authors: Francesca Benedetti, Sabrina Curreli, Robert C. Gallo and Davide Zella

    Citation: Journal of Translational Medicine 2021 19:60

    Content type: Research

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  27. Colorectal cancer (CRC) is a common malignant tumor globally. Meanwhile, LINC01116 has been proposed as risk factor for various tumors, including CRC. But the regulation of LINC01116 in CRC required more valid...

    Authors: Weijie Liang, Jie Wu and Xinguang Qiu

    Citation: Journal of Translational Medicine 2021 19:45

    Content type: Research

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  28. Non-small cell lung cancer (NSCLC) is a common type of lung cancer. Extracellular vehicles (EVs) are nano-sized particles containing proteins, lipids, and miRNAs secreted by various cells, which play important...

    Authors: Liming Gao, Qi Tian, Tong Wu, Shanshan Shi, Xiaobo Yin, Lijie Liu, Lei Zheng, Ping Wang, Yaling Tian and Shufeng Xu

    Citation: Journal of Translational Medicine 2021 19:37

    Content type: Research

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  29. The ability of tumor cells to spread from their origin place and form secondary tumor foci is determined by the epithelial–mesenchymal transition process. In epithelial tumors such as prostate cancer (PCa), th...

    Authors: Martyna Parol, Arkadiusz Gzil, Magdalena Bodnar and Dariusz Grzanka

    Citation: Journal of Translational Medicine 2021 19:28

    Content type: Review

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  30. Driver genes of GBM may be crucial for the onset of isocitrate dehydrogenase (IDH)-wildtype (WT) glioblastoma (GBM). However, it is still unknown whether the genes are expressed in the identical cluster of cells....

    Authors: Seon-Jin Yoon, Hye Young Son, Jin-Kyoung Shim, Ju Hyung Moon, Eui-Hyun Kim, Jong Hee Chang, Wan Yee Teo, Se Hoon Kim, Sahng Wook Park, Yong-Min Huh and Seok-Gu Kang

    Citation: Journal of Translational Medicine 2020 18:482

    Content type: Research

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  31. Platelet derived growth factor receptor alpha (PDGFRα) has been considered as a relevant factor in tumor proliferation, angiogenesis and metastatic dissemination. It was a target of tyrosine kinase (TK) inhibi...

    Authors: Nadia Ben Jemii, Haifa Tounsi-Kettiti, Hamza Yaiche, Najla Mezghanni, Amira Jaballah Gabteni, Emna Fehri, Chayma Ben Fayala, Sonia Abdelhak and Samir Boubaker

    Citation: Journal of Translational Medicine 2020 18:440

    Content type: Research

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  32. Cancer stem cells (CSCs) play an important role in drug resistance, recurrence, and metastasis of tumors. Considering the heterogeneity of tumors, this study aimed to explore the key genes regulating stem cell...

    Authors: Rui Guo, Aining Chu and Yuehua Gong

    Citation: Journal of Translational Medicine 2020 18:418

    Content type: Research

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  33. Molecular classification has laid the framework for exploring glioma biology and treatment strategies. Pro-neural to mesenchymal transition (PMT) of glioma is known to be associated with aggressive phenotypes,...

    Authors: Qingyu Liang, Gefei Guan, Xue Li, Chunmi Wei, Jianqi Wu, Peng Cheng, Anhua Wu and Wen Cheng

    Citation: Journal of Translational Medicine 2020 18:378

    Content type: Research

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