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Translational cancer biology

Section edited by Cristina Maccalli

This section aims to provide a platform for the communication and dissemination of advances in cancer biology and their translational applications. Studies considered for publication include those dissecting the mechanisms of transformation, progression and metastatization, the biology of cancer stem cells and their immunological properties, the mechanisms undergoing the epithelial-to mesenchymal (EMT) transition and tumor dormancy, their relationship with immune functions and the mechanisms undergoing cancer resistance to therapies. 

This section is also dedicated to those investigations dedicated to the translational aspects and the development of novel therapies related to the aforementioned themes and the identification of patient’s responsiveness and outcome to therapies.

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  1. An increasing number of studies have demonstrated that long non-coding RNAs (lncRNAs) serve as key regulators in tumor development and progression. However, only a few lncRNAs have been functionally characteri...

    Authors: Jixu Wang, Futao Hou, Lusheng Tang, Ke Xiao, Tengfei Yang, Zhiqiang Wang and Gu Liu
    Citation: Journal of Translational Medicine 2022 20:220
  2. NOS1 expression predicts poor prognosis in patients with melanoma. However, the molecular function of NOS1 in the type I IFN response and immune escape of melanoma is still unknown.

    Authors: Xi Chen, Zhiwei Zou, Qianli Wang, Wenwen Gao, Sisi Zeng, Shuangyan Ye, Pengfei Xu, Mengqiu Huang, Keyi Li, Jianping Chen, Zhuo Zhong, Qianbing Zhang, Bingtao Hao and Qiuzhen Liu
    Citation: Journal of Translational Medicine 2022 20:205
  3. Knowledge of the role of CYP2E1 in hepatocarcinogenesis is largely based on epidemiological and animal studies, with a primary focus on the role of CYP2E1 in metabolic activation of procarcinogens. Few studies...

    Authors: Lili Zhu, Xiaobei Yang, Jingyu Feng, Jian Mao, Qidong Zhang, Mengru He, Yang Mi, Yingwu Mei, Ge Jin and Haifeng Zhang
    Citation: Journal of Translational Medicine 2022 20:194
  4. Triosephosphate isomerase 1 (TPI1), as a key glycolytic enzyme, is upregulated in multiple cancers. However, expression profile and regulatory mechanism of TPI1 in breast cancer (BRCA) remain mysterious.

    Authors: Xiaoying Jin, Dandan Wang, Mengxia Lei, Yan Guo, Yuqing Cui, Fengzhi Chen, Weiling Sun and Xuesong Chen
    Citation: Journal of Translational Medicine 2022 20:191
  5. Studies have revealed an important role of activating transcription factor 1 (ATF1) and phosphorylated ATF1 at Ser63 in tumors. Our previous study identified Thr184 as a novel phosphorylation site of ATF1. How...

    Authors: Tong Li, Huiyuan Cao, Sa Wu, Peimin Zhong, Jie Ding, Jing Wang, Fangfang Wang, Zhiwei He and Guo-Liang Huang
    Citation: Journal of Translational Medicine 2022 20:169
  6. Metastasis is critical for endometrial cancer (EC) progression and prognosis. Accumulating evidence suggests that circular RNAs (circRNAs) can operate as independent functional entities. However, the functiona...

    Authors: Rui Shi, Wei Zhang, Jun Zhang, Zhicheng Yu, Lanfen An, Rong Zhao, Xing Zhou, Ziwei Wang, Sitian Wei and Hongbo Wang
    Citation: Journal of Translational Medicine 2022 20:139
  7. Prostate cancer is the second most common cancer in men, and some new target genes are needed to predict the risk of prostate cancer progression and the treatment.

    Authors: Xing-cheng Wu, Yu-zhong Yu, Yu-zhi Zuo, Xian-Lu Song, Zhi-en Zhou, Yu Xiao, Dao-sheng Luo, Wei-gang Yan and Shan-Chao Zhao
    Citation: Journal of Translational Medicine 2022 20:91
  8. Peroxisome proliferator-activated receptor-beta/delta (PPARδ) was considered as the key regulator involved in the evolution of various tumors. Given that PPARδ potential role in hepatocellular carcinoma (HCC) ...

    Authors: Wei Han, Nan Wang, Rui Kong, Wen Bao and Jie Lu
    Citation: Journal of Translational Medicine 2022 20:86
  9. Papillary thyroid carcinoma (PTC) is one of most prevalent malignant endocrine neoplasms, and it is associated with a high frequency of BRAF gene mutations, which lead to lymphatic metastasis and distant metas...

    Authors: Xing Chen, Shan Lin, Ying Lin, Songsong Wu, Minling Zhuo, Ailong Zhang, Junjie Zheng and Zhenhui You
    Citation: Journal of Translational Medicine 2022 20:79
  10. Adrenocortical carcinoma (ACC) is an aggressive and rare malignant tumor and is prone to local invasion and metastasis. And, overexpressed Centromere Protein F (CENPF) is closely related to the oncogenesis of ...

    Authors: Yu-gang Huang, Dan Li, Li Wang, Xiao-min Su and Xian-bin Tang
    Citation: Journal of Translational Medicine 2022 20:78
  11. Emerging evidence suggests that long non-coding RNAs (lncRNAs) play important roles in the metastasis and recurrence of hepatocellular carcinoma (HCC). A kinds of lncRNAs were found to be involved in regulatin...

    Authors: Zhanjun Chen, Leyang Xiang, Longhai Li, Huohui Ou, Yinghao Fang, Yuyan Xu, Qin Liu, Zhigang Hu, Yu Huang, Xianghong Li and Dinghua Yang
    Citation: Journal of Translational Medicine 2022 20:75
  12. Long non-coding RNAs (lncRNAs) are involved in the development of hepatocellular carcinoma (HCC). We aimed to investigate the function of LINC01146 in HCC.

    Authors: Xiaoyun Ma, Meile Mo, Chao Tan, Jennifer Hui Juan Tan, Huishen Huang, Bihu Liu, Dongping Huang, Shun Liu, Xiaoyun Zeng and Xiaoqiang Qiu
    Citation: Journal of Translational Medicine 2022 20:57
  13. Chronic kidney disease (CKD) is characterized by high morbidity and mortality and is difficult to cure. Renal interstitial fibrosis (RIF) is a major determinant of, and commonly occurs within, CKD progression....

    Authors: Jieqing Zhou, Hong Jiang, Hongkun Jiang, Yan Fan, Jing Zhang, Xiaoxue Ma, Xuewei Yang, Yu Sun and Xing Zhao
    Citation: Journal of Translational Medicine 2022 20:54
  14. Cervical cancer (CC) is one of the most common gynecological tumors that threatens women's health and lives. Aberrant expression of PIWI-interacting RNA (piRNA) is closely related with a range of cancers and c...

    Authors: Qi Xie, Zhen Li, Xiao Luo, Dan Wang, Yao Zhou, Jingge Zhao, Suhua Gao, Yongguang Yang, Wanying Fu, Lingfei Kong and Tingyi Sun
    Citation: Journal of Translational Medicine 2022 20:51
  15. FOXA1 is associated with malignant tumors, but the function of FOXA1 in EOC is unclear. HDAC3 can influence the proliferation, migration and invasion ability of EOC. In this study, we wanted to explore the fun...

    Authors: Tong Lou, Chongdong Liu, Hong Qu, Zhiqiang Zhang, Shuzhen Wang and Huiyu Zhuang
    Citation: Journal of Translational Medicine 2022 20:19
  16. Cytidine nucleotide triphosphate synthase 1 (CTPS1) is a CTP synthase which play critical roles in DNA synthesis. However, its biological regulation and mechanism in triple-negative breast cancer (TNBC) has no...

    Authors: Yuxiang Lin, Jie Zhang, Yan Li, Wenhui Guo, Lili Chen, Minyan Chen, Xiaobin Chen, Wenzhe Zhang, Xuan Jin, Meichen Jiang, Han Xiao, Chuan Wang, Chuangui Song and Fangmeng Fu
    Citation: Journal of Translational Medicine 2022 20:17
  17. Exosomes, membranous nanovesicles, naturally bringing proteins, mRNAs, and microRNAs (miRNAs), play crucial roles in tumor pathogenesis. This study was to investigate the role of miR-155-3p from M2 macrophages...

    Authors: Li Song, Bin Luan, Qingrong Xu, Ruihe Shi and Xiufang Wang
    Citation: Journal of Translational Medicine 2022 20:13
  18. LINC00491 was involved in some tumors development, but its function in liver cancer has not been reported. This study aimed to investigate LINC00491 expression and function in liver cancer progression.

    Authors: Wei Wang, Tao Yang, Dongsheng Li, Yinpeng Huang, Guang Bai and Qing Li
    Citation: Journal of Translational Medicine 2021 19:504
  19. Breast cancer remains one of the most dreadful female malignancies globally, in which cancer stem cells (CSCs) play crucial functions. Circular RNAs have drawn great attention in cancer research area and propo...

    Authors: Yi-Ping Liu, Jin-Yu Heng, Xin-Yu Zhao and En-You Li
    Citation: Journal of Translational Medicine 2021 19:467
  20. Circular RNAs (circRNAs) are pivotal regulators of various human cancers and circ-ERBB2 is abnormally expressed in breast cancer cells. However, the role and mechanism of circ-ERBB2 in HER2-positive breast can...

    Authors: Jin-xiu Zhong, Yun-yuan Kong, Rong-guang Luo, Guo-jin Xia, Wen-xing He, Xue-zhong Chen, Wei-wei Tan, Qing-jie Chen, Yu-yin Huang and Yan-xing Guan
    Citation: Journal of Translational Medicine 2021 19:455
  21. Gastric cancer (GC) is the fifth most commonly diagnosed cancer worldwide. Due to the dismal prognosis, identifying novel therapeutic targets in GC is urgently needed. Evidences have shown that miRNAs played c...

    Authors: Yixun Lu, Benlong Zhang, Baohua Wang, Di Wu, Chuang Wang, Yunhe Gao, Wenquan Liang, Hongqing Xi, Xinxin Wang and Lin Chen
    Citation: Journal of Translational Medicine 2021 19:432
  22. Colorectal cancer is one of the most common malignancy in the world. It has been reported that cancer stem cells (CSCs) serve as the primary drivers of tumorigenesis and tumor progression. There is an urgent n...

    Authors: Yifan Li, Jing Xun, Botao Wang, Yuan Ma, Lanqiu Zhang, Lei Yang, Ruifang Gao, Jun Guan, Tianyu Liu, Hejun Gao, Ximo Wang and Qi Zhang
    Citation: Journal of Translational Medicine 2021 19:429
  23. This research aimed to investigate the expression and function of FAM83A in the proliferation and metastasis in head and neck squamous cell carcinoma (HNSCC). FAM83A mRNA and protein expressions in HNSCC were ...

    Authors: Huan Ji, Haiyang Song, Zeyu Wang, Pengfei Jiao, Jiani Xu, Xuan Li, Hongming Du, Heming Wu and Yi Zhong
    Citation: Journal of Translational Medicine 2021 19:423
  24. Clear cell renal cell carcinoma (ccRCC) is the most common malignant tumor of the kidney. New and reliable biomarkers are in urgent need for ccRCC diagnosis and prognosis. The CENP family is overexpressed in m...

    Authors: Qi Wang, Jiaju Xu, Zhiyong Xiong, Tianbo Xu, Jingchong Liu, Yuenan Liu, Jiaping Chen, Jian Shi, Yi Shou, Changjie Yue, Di Liu, Huageng Liang, Hongmei Yang, Xiong Yang and Xiaoping Zhang
    Citation: Journal of Translational Medicine 2021 19:417
  25. Cancer stem cells (CSCs) are key regulators in the processes of tumor initiation, progression, and recurrence. The mechanism that maintains their stemness remains enigmatic, although the role of several long n...

    Authors: Yu-Shui Ma, Xiao-Li Yang, Yu-Shan Liu, Hua Ding, Jian-Jun Wu, Yi Shi, Cheng-You Jia, Gai-Xia Lu, Dan-Dan Zhang, Hui-Min Wang, Pei-Yao Wang, Fei Yu, Zhong-Wei Lv, Gao-Ren Wang, Ji-Bin Liu and Da Fu
    Citation: Journal of Translational Medicine 2021 19:400
  26. EMT is an important biological process in the mechanism of tumor invasion and metastasis. However, there are still many unknowns about the specific mechanism of EMT in tumor. At present, a comprehensive analys...

    Authors: Yang Yang, Mingyang Feng, LiangLiang Bai, Weiting Liao, Kexun Zhou, Mengxi Zhang, Qiuji Wu, Feng Wen, Wanting Lei, Pengfei Zhang, Nan Zhang, Jiaxing Huang and Qiu Li
    Citation: Journal of Translational Medicine 2021 19:391
  27. The recurrence and metastasis of nasopharyngeal cancer (NPC) may be mainly attributed to the persistence of cancer stem cells (CSCs); however, the linkage mechanism has yet to be fully elucidated.

    Authors: Mengyang Zhao, Zibo Tang, Yijun Wang, Jiaojiao Ding, Ying Guo and Tianhui Gao
    Citation: Journal of Translational Medicine 2021 19:387
  28. Ubiquitin-conjugating enzyme E2T (UBE2T) acts as an oncogene in various types of cancer. However, the mechanisms behind its oncogenic role remain unclear in lung cancer. This study aims to explore the function...

    Authors: Jinhong Zhu, Haijiao Ao, Mingdong Liu, Kui Cao and Jianqun Ma
    Citation: Journal of Translational Medicine 2021 19:374
  29. Although the rapid development of diagnosis and treatment has improved prognosis in early breast cancer, challenges from different therapeutic response remain due to breast cancer heterogeneity. DEAD-box helic...

    Authors: Shan Li, Jinfei Ma, Ang Zheng, Xinyue Song, Si Chen and Feng Jin
    Citation: Journal of Translational Medicine 2021 19:334
  30. Pancreatic cancer (PC) is one of the most fatal digestive system cancers. tripartite motif-29 (TRIM29) has been reported as oncogene in several human cancers. However, the precise role and underlying signal ca...

    Authors: Xueqiang Deng, Xiaowei Fu, Hong Teng, Lu Fang, Bo Liang, Rengui Zeng, Lian Chen and Yeqing Zou
    Citation: Journal of Translational Medicine 2021 19:332
  31. Circular RNA (circRNA) has been demonstrated to participate in cervical cancer development. In this study, we analyzed the role of hsa_circ_0000520 in cervical cancer.

    Authors: Qingling Zheng, Jin Zhang, Ting Zhang, Yanxiang Liu, Xiuluan Du, Xin Dai and Donghua Gu
    Citation: Journal of Translational Medicine 2021 19:314
  32. Colorectal cancer (CRC) is a common malignant tumour of the digestive tract that is characterized by high patient morbidity and mortality rates. Claudin-7 (Cldn7), a tight junction protein, was recently report...

    Authors: Chang Xu, Yu-han Ding, Kun Wang, Mengdi Hao, Huimin Li and Lei Ding
    Citation: Journal of Translational Medicine 2021 19:311
  33. Metastasis and invasion are crucial in determining the mortality of cervical carcinoma (CC) patients. The epithelial–mesenchymal transition (EMT) is now a universal explanation for the mechanisms of tumor meta...

    Authors: Haoqi Zhao, Lan Wang, Shufang Wang, Xihua Chen, Min Liang, Xin Zhang, Jiedong Wang and Xiangbo Xu
    Citation: Journal of Translational Medicine 2021 19:295
  34. Colorectal cancer is the third most common diagnosis. Oxaliplatin is used as first-line treatment of colon cancer. However, oxaliplatin resistance greatly reduces its therapeutic effect. SRPK1 involves in pre-...

    Authors: Jing-Qiang Huang, He-Feng Li, Jing Zhu, Jun-Wei Song, Xian-Bin Zhang, Peng Gong, Qiu-Yu Liu, Chun-Hui Zhou, Liang Wang and Li-Yun Gong
    Citation: Journal of Translational Medicine 2021 19:280
  35. Intratumour heterogeneous gene expression among cancer and cancer stem cells (CSCs) can cause failure of current targeted therapies because each drug aims to target the function of a single gene. Long mononucl...

    Authors: Narumol Bhummaphan, Piyapat Pin-on, Preeyaporn Plaimee Phiboonchaiyanan, Jirattha Siriluksana, Chatchawit Aporntewan, Pithi Chanvorachote and Apiwat Mutirangura
    Citation: Journal of Translational Medicine 2021 19:231
  36. There is growing evidence discussing the role of long non-coding RNAs (lncRNAs) in cervical cancer (CC). We performed this study to explore the impact of exosomal lncRNA urothelial cancer-associated 1 (UCA1) i...

    Authors: Zhihui Gao, Qianqing Wang, Mei Ji, Xiangcui Guo, Li Li and Xiaoke Su
    Citation: Journal of Translational Medicine 2021 19:229
  37. It has been established that microRNA (miR)-449a is anti-tumorigenic in cancers, including lung cancer. Therefore, this study further explored miR-449a-mediated mechanism in lung cancer, mainly focusing on lys...

    Authors: Shan Hu, Peng Cao, Kangle Kong, Peng Han, Yu Deng, Fan Li and Bo Zhao
    Citation: Journal of Translational Medicine 2021 19:224
  38. Generally, cancer cells undergo metabolic reprogramming to adapt to energetic and biosynthetic requirements that support their uncontrolled proliferation. However, the mutual relationship between two critical ...

    Authors: Guoshu Bi, Yunyi Bian, Jiaqi Liang, Jiacheng Yin, Runmei Li, Mengnan Zhao, Yiwei Huang, Tao Lu, Cheng Zhan, Hong Fan and Qun Wang
    Citation: Journal of Translational Medicine 2021 19:219
  39. Eukaryotic translation initiation factor 6 (eIF6) has a crucial function in the maturation of 60S ribosomal subunits, and it controls the initiation of protein translation. Although emerging studies indicate t...

    Authors: Liping Sun, Shuguang Liu, Xiaopai Wang, Xuefeng Zheng, Ya Chen and Hong Shen
    Citation: Journal of Translational Medicine 2021 19:216
  40. As a significant cause of malignancy mortality, gastric carcinoma (GC) has been well documented to be an often-fatal diagnosis. Despite the limitations of effective therapy, immunotherapy has emerged as a prom...

    Authors: Qianmei Fu, Xiaohong Tan, Huaming Tang and Jijiang Liu
    Citation: Journal of Translational Medicine 2021 19:210
  41. Clear cell renal cell carcinoma (ccRCC) is the most common and aggressive type of renal malignancy. Methyltransferase like 13 (METTL13) functions as an oncogene in most of human cancers, but its function and m...

    Authors: Zhuonan Liu, Tianshui Sun, Chiyuan Piao, Zhe Zhang and Chuize Kong
    Citation: Journal of Translational Medicine 2021 19:209
  42. Tumor metastasis is the main cause of death of cancer patients, and cancer stem cells (CSCs) is the basis of tumor metastasis. However, systematic analysis of the stemness of prostate cancer cells is still not...

    Authors: Zao Dai and Ping Liu
    Citation: Journal of Translational Medicine 2021 19:206
  43. Lung cancer is one of the most widely spread cancers in the world and half of the non-small cell lung cancers are lung adenocarcinoma (LUAD). Although there were several drugs been approved for LUAD therapy, a...

    Authors: Guangyan Kan, Ziyang Wang, Chunjie Sheng, Chen Yao, Yizhi Mao and Shuai Chen
    Citation: Journal of Translational Medicine 2021 19:161
  44. CKLF like MARVEL transmembrane domain containing 6 (CMTM6) has been associated with the development in many kinds of cancers. However, the roles of CMTM6 in hepatocellular carcinoma (HCC) are largely unknown. ...

    Authors: Xiaoting Huang, Leyang Xiang, Baiyao Wang, Jijie Hu, Chunshan Liu, Anbang Ren, Kunpeng Du, Gengtai Ye, Yingying Liang, Yunqiang Tang, Dinghua Yang and Yawei Yuan
    Citation: Journal of Translational Medicine 2021 19:120
  45. Glucose-regulating protein 78 (GRP78) is a molecular chaperone in the endoplasmic reticulum (ER) that promotes folding and assembly of proteins, controls the quality of proteins, and regulates ER stress signal...

    Authors: Shengkai Xia, Wenzhe Duan, Wenwen Liu, Xinri Zhang and Qi Wang
    Citation: Journal of Translational Medicine 2021 19:118
  46. Ovarian cancer (OV) is the deadliest gynecological cancer. Transmembrane protein 119 (TMEM119) has been reported as oncogene in several human cancers. However, the function of TMEM119 in OV is still poorly known.

    Authors: Tianshui Sun, Fangfang Bi, Zhuonan Liu and Qing Yang
    Citation: Journal of Translational Medicine 2021 19:111