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Translational Cancer Biology

Section edited by Cristina Maccalli

This section aims to provide a platform for the communication and dissemination of advances in cancer biology and their translational applications. Studies considered for publication include those dissecting the mechanisms of transformation, progression and metastatization, the biology of cancer stem cells and their immunological properties, the mechanisms undergoing the epithelial-to mesenchymal (EMT) transition and tumor dormancy, their relationship with immune functions and the mechanisms undergoing cancer resistance to therapies. 

This section is also dedicated to those investigations dedicated to the translational aspects and the development of novel therapies related to the aforementioned themes and the identification of patient’s responsiveness and outcome to therapies.

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  1. Human discs large-associated protein 5 (DLGAP5) is reported to play a pivotal role in regulating the cell cycle and implicate in tumorigenesis and progression of various cancers. Our current research endeavore...

    Authors: Maojian Chen, Shaoping Zhang, Fan Wang, Junyi He, Wei Jiang and Li Zhang
    Citation: Journal of Translational Medicine 2024 22:209
  2. DNMT3L is a crucial DNA methylation regulatory factor, yet its function and mechanism in hepatocellular carcinoma (HCC) remain poorly understood. Bioinformatics-based big data analysis has increasingly gained ...

    Authors: Xiaokai Yan, Yao Qi, Xinyue Yao, Nanjing Zhou, Xinxin Ye and Xing Chen
    Citation: Journal of Translational Medicine 2024 22:128
  3. Malignant progression is the major cause of poor prognosis in breast cancer (BC) patients. Plasma exosomal miRNAs have been reported to be involved in tumor progression, but their roles in BC remain unclear.

    Authors: Yao Li, Lei Fan, An Yan, Xiaotian Ren, Yanyang Zhao and Bin Hua
    Citation: Journal of Translational Medicine 2024 22:112
  4. Cancer stem cells (CSCs) are a small population of cells in tumor tissues that can drive tumor initiation and promote tumor progression. A small number of previous studies indirectly mentioned the role of F-bo...

    Authors: Guodong Xiao, Weiping Lu, Jing Yuan, Zuyue Liu, Peili Wang and Huijie Fan
    Citation: Journal of Translational Medicine 2024 22:99
  5. Prostate cancer (PCa) is the second leading cause of cancer-related mortality among men worldwide, and its incidence has risen substantially in recent years. Therefore, there is an urgent need to identify nove...

    Authors: Enchong Zhang, Zhengjie Chen, Wangmin Liu, Lin Lin, Lina Wu, Johnny Guan, Jianfeng Wang, Chuize Kong, Jianbin Bi and Mo Zhang
    Citation: Journal of Translational Medicine 2024 22:12
  6. Tandem C2 domains, nuclear (TC2N) is a C2 domain-containing protein that belongs to the carboxyl-terminal type (C-type) tandem C2 protein family, and acts as an oncogenic driver in several cancers. Previously,...

    Authors: Xiang-lin Hao, Yang-fan Lv, De-feng Li, Fu-hai Bai, Ji Gong, Guang-qiang Pan, Lin-xi Su, Ya-li Wang, Wan-lei Fu, Bo Liu, Lu Huang, Dong Yan, Qiu-lin Tan, Jin-yi Liu and Qiao-nan Guo
    Citation: Journal of Translational Medicine 2024 22:6
  7. Mutations in TP53 gene is considered a main driver of hepatocellular carcinoma (HCC). While TP53 mutations are the leading cause of p53 dysfunction, their occurrence rates may drop to approximately 10% in cohorts...

    Authors: Chun Wang, Hui Kang, Yun Yi, Yang Ding, Fan Wang, Jie Luo, Mingliang Ye, Yinghui Hong, Chao Xia, Junwei Yan, Lan Liu, Jing Liu, Zibiao Zhong, Zhonglin Zhang, Qiu Zhao and Ying Chang
    Citation: Journal of Translational Medicine 2023 21:919
  8. Pancreatic cancer is an aggressive malignancy with high mortality, and cancer cell stemness and related drug resistance are considered important contributors to its poor prognosis. The objective of this study ...

    Authors: Xiao-hui Li, Gui-zhong Huang, Zi-lan Xu, Chong-yu Zhao, Xiao-yuan Dong, Bo-kang Cui and Xiao-jun Lin
    Citation: Journal of Translational Medicine 2023 21:911
  9. The occurrence of epithelial-mesenchymal transition (EMT) and immune evasion is considered to contribute to poor prognosis in lung adenocarcinoma (LUAD). Therefore, this study aims to explore the key oncogenes...

    Authors: Yafeng Liu, Tao Han, Jing Wu, Jiawei Zhou, Jianqiang Guo, Rui Miao, Zhi Xu, Yingru Xing, Ying Bai and Dong Hu
    Citation: Journal of Translational Medicine 2023 21:909
  10. Complement component 3a and its receptor (C3a/C3aR) and the nucleotide-binding oligomerization domain-like receptor protein-3 (NLRP3) inflammasome contribute to epithelial-mesenchymal transition (EMT). However...

    Authors: Danyu You, Kun Nie, Xiaoting Wu, Mengjie Weng, Liyan Yang, Yi Chen, Jiong Cui and Jianxin Wan
    Citation: Journal of Translational Medicine 2023 21:904
  11. Ovarian cancer is the leading cause of death from gynecologic illnesses worldwide. High-grade serous ovarian cancer (HGSOC) is a gynecological tumor that accounts for roughly 70% of ovarian cancer deaths in wo...

    Authors: Yuanzhi Chen, Zhicheng He, Shuting Yang, Cheng Chen, Wenyong Xiong, YingYing He and Shubai Liu
    Citation: Journal of Translational Medicine 2023 21:886
  12. Sine oculis homeobox homolog 1 (SIX1) is a transcription factor that has recently been identified as a crucial regulator of embryonic development and tumorigenesis. SIX1 is upregulated in different types of tu...

    Authors: Liantao Guo, Faminzi Li, Hanqing Liu, Deguang Kong, Chuang Chen and Shengrong Sun
    Citation: Journal of Translational Medicine 2023 21:866
  13. Glioblastoma, the most common primary malignant tumor of the brain, is associated with poor prognosis. Glioblastoma cells exhibit high proliferative and invasive properties, and glioblastoma stem cells (GSCs) ...

    Authors: Zhiyuan Liu, Songtao Wang, Kuo Yu, Kaile Chen, Liang Zhao, Jiayue Zhang, Kexiang Dai and Peng Zhao
    Citation: Journal of Translational Medicine 2023 21:863
  14. N6-methyladenosine (m6A) is the most prevalent RNA modification. Although hnRNPA2B1, as a reader of m6A modification, has been reported to promote tumorigenesis in a few types of tumors, its role in hepatocell...

    Authors: Weijie Hao, Zhimin Chen, Jingzhi Tang, Ru Yang, Wei-Qiang Gao and Huiming Xu
    Citation: Journal of Translational Medicine 2023 21:861
  15. Anaplastic thyroid carcinoma (ATC) is a deadly disease with a poor prognosis. Thus, there is a pressing need to determine the mechanism of ATC progression. The homeobox D9 (HOXD9) transcription factor has been...

    Authors: Yong Zhong, Fan Yu, Ling Yang, Yu Wang, Lin Liu, Chengyou Jia, Haidong Cai, Jianshe Yang, Shiyang Sheng, Zhongwei Lv, Li Weng, Bo Wu and Xiaoping Zhang
    Citation: Journal of Translational Medicine 2023 21:817
  16. The occurrence and progression of tumors can be established through a complex interplay among tumor cells undergoing epithelial-mesenchymal transition (EMT), invasive factors and immune cells. In this study, w...

    Authors: Muhong Wang, Chunyu Deng, Cheng Yang, Mingze Yan, Haibo Lu, Yan Zhang, Honghao Liu, Zhekuan Tong, Jiaao Ma, Jiaming Wang, Yan Zhang, Jiahao Wang, Yuhong Xuan, Haiyue Cheng, Kai Zhao, Jiaqi Zhang…
    Citation: Journal of Translational Medicine 2023 21:794
  17. Prostate cancer (PCA) is the fifth leading cause of cancer-related deaths worldwide, with limited treatment options in the advanced stages. The immunosuppressive tumor microenvironment (TME) of PCA results in ...

    Authors: Kun Zheng, Youlong Hai, Yue Xi, Yukun Zhang, Zheqi Liu, Wantao Chen, Xiaoyong Hu, Xin Zou and Jie Hao
    Citation: Journal of Translational Medicine 2023 21:789
  18. Gastric cancer (GC) ranks as the fifth most common cancer worldwide and is characterized by its significant heterogeneity and unfavorable prognosis. Thus, identifying efficient prognostic factors and understan...

    Authors: Fangyuan Qi, Yaru Wang, Bingxin Yu and Fan Li
    Citation: Journal of Translational Medicine 2023 21:766
  19. Triple-negative breast cancer (TNBC) development may be associated with tumor immune escape. This study explores whether the CHI3L1/MAF/CTLA4/S100A4 axis affects immune escape in TNBC through interplay with tr...

    Authors: Shufeng Ji, Hao Yu, Dan Zhou, Xulong Fan, Yan Duan, Yijiang Tan, Min Lang and Guoli Shao
    Citation: Journal of Translational Medicine 2023 21:721
  20. Polyploid giant cancer cells (PGCCs), a specific type of cancer stem cells (CSCs), can be induced by hypoxic microenvironments, chemical reagents, radiotherapy, and Chinese herbal medicine. Moreover, PGCCs can...

    Authors: Linlin Fan, Minying Zheng, Xinyue Zhou, Yongjun Yu, Yidi Ning, Wenzheng Fu, Jing Xu and Shiwu Zhang
    Citation: Journal of Translational Medicine 2023 21:719
  21. Cancer stem cells (CSCs) have emerged as key contributors to tumor initiation, growth, and metastasis. In addition, CSCs play a significant role in inducing immune evasion, thereby compromising the effectivene...

    Authors: Yan-Ruide Li, Ying Fang, Zibai Lyu, Yichen Zhu and Lili Yang
    Citation: Journal of Translational Medicine 2023 21:686
  22. Gastric cancer (GC) is a fatal cancer with unclear pathogenesis. In this study, we explored the function and potential mechanisms of intercellular adhesion molecule 2 (ICAM2) in the development and advancement...

    Authors: Xiaocheng Tang, Jintuan Huang, Yingming Jiang, Jun Qiu, Tuoyang Li, Weiyao Li, Zijian Chen, Zhenze Huang, Xihu Yu, Tao Yang, Xiang Ji, Rongchang Tan, Li lv, Zuli Yang and Hao Chen
    Citation: Journal of Translational Medicine 2023 21:670
  23. Ladinin-1 (LAD1), an anchoring filament protein, has been associated with several cancer types, including cancers of the colon, lungs, and breast. However, it is still unclear how and why LAD1 causes gastric c...

    Authors: Yingming Jiang, Yanchun Feng, Jintuan Huang, Zhenze Huang, Rongchang Tan, Tuoyang Li, Zijian Chen, Xiaocheng Tang, Jun Qiu, Chujun Li, Hao Chen and Zuli Yang
    Citation: Journal of Translational Medicine 2023 21:632
  24. Increasing evidence suggests that hepatocellular carcinoma (HCC) stem cells (LCSCs) play an essential part in HCC recurrence, metastasis, and chemotherapy and radiotherapy resistance. Multiple studies have dem...

    Authors: Rui Liang, Weifeng Hong, Yang Zhang, Di Ma, Jinwei Li, Yisong Shi, Qing Luo, Shisuo Du and Guanbin Song
    Citation: Journal of Translational Medicine 2023 21:631
  25. Fibroblast growth factor receptor (FGFR) gene family alterations are found in several cancers, indicating their importance as potential therapeutic targets. The FGFR-tyrosine kinase inhibitor (TKI) pemigatinib...

    Authors: Angelica Pace, Fabio Scirocchi, Chiara Napoletano, Ilaria Grazia Zizzari, Agnese Po, Francesca Megiorni, Angela Asquino, Paola Pontecorvi, Hassan Rahimi, Cinzia Marchese, Elisabetta Ferretti, Marianna Nuti and Aurelia Rughetti
    Citation: Journal of Translational Medicine 2023 21:626
  26. Colorectal cancer (CRC) has become a global health problem which has almost highest morbidity and mortality in all types of cancers. This study aimed to uncover the biological functions and underlying mechanis...

    Authors: Shaojun Yu, Weixing Dai, Senlin Zhao, Yongzhi Yang, Ye Xu, Jianwei Wang, Qun Deng, Jinghu He and Debing Shi
    Citation: Journal of Translational Medicine 2023 21:623
  27. A chromobox homologue 3 (CBX3) is elevated in various cancers and significantly contributes to the promotion of malignant behavior; despite this, its exact involvement in clear cell renal cell carcinoma (ccRCC...

    Authors: Jiasheng Chen, Yuxin Lin, Shukai zheng, Qingshan Chen, Shijie Tang and Xiaoping Zhong
    Citation: Journal of Translational Medicine 2023 21:600
  28. Pancreatic ductal adenocarcinoma (PDAC) is expected to soon surpass colorectal cancer as a leading cause of cancer mortality in both males and females in the US, only lagging behind lung cancer. The lethality ...

    Authors: Nuno Bastos, Stéphanie A. Castaldo, Bárbara Adem, José C. Machado, Carlos A. Melo and Sonia A. Melo
    Citation: Journal of Translational Medicine 2023 21:578
  29. Alpha-melanocyte stimulating hormone (α-MSH) and its receptor, melanocortin 1 receptor (MC1R), have been proposed as potential target for anti-cancer strategies in melanoma research, due to their tissue specif...

    Authors: Luigi Dall’Olmo, Nicole Papa, Nicoletta Concetta Surdo, Ilaria Marigo and Simone Mocellin
    Citation: Journal of Translational Medicine 2023 21:562
  30. Hepatocellular carcinoma (HCC) is one of the most prevalent malignancies worldwide because of rapid progression and high incidence of metastasis or recurrence. Accumulating evidence shows that CD58-expressing ...

    Authors: Chuanzheng Wang, Fei Cao, Jiahao Cao, Zhen Jiao, Yuting You, Yu Xiong, Wenxiu Zhao and Xiaomin Wang
    Citation: Journal of Translational Medicine 2023 21:539
  31. Epithelial cell adhesion molecule (EpCAM) is known to highly expression and promotes cancer progression in many cancer types, including colorectal cancer. While metastasis is one of the main causes of cancer t...

    Authors: Chi-Chiu Lee, Chia-Jui Yu, Sushree Shankar Panda, Kai-Chi Chen, Kang-Hao Liang, Wan-Chen Huang, Yu-Shiuan Wang, Pei-Chin Ho and Han-Chung Wu
    Citation: Journal of Translational Medicine 2023 21:530

    The Correction to this article has been published in Journal of Translational Medicine 2024 22:36

  32. Breast cancer (BC) has posed a great threat to world health as the leading cause of cancer death among women. Previous evidence demonstrated that germ cell-specific gene 2 (GSG2) was involved in the regulation...

    Authors: Yu Tang, Gaosai Dai, Yupeng Yang and Huantao Liu
    Citation: Journal of Translational Medicine 2023 21:523
  33. Programmed cell death (PCD) plays an important role in many aspects of individual development, maintenance of body homeostasis and pathological processes. Ferroptosis is a novel form of PCD characterized by th...

    Authors: Qi Zhang, Xinfeng Fan, Xinyu Zhang and Shaoqing Ju
    Citation: Journal of Translational Medicine 2023 21:514
  34. Bladder cancer is one of the most common malignant tumors of the urinary system and is associated with a poor prognosis once invasion and distant metastases occur. Epithelial-mesenchymal transition (EMT) drive...

    Authors: Qinrong Ping, Chunhui Wang, Xin Cheng, Yiming Zhong, Ruping Yan, Meng Yang, Yunqiang Shi, Xiangmeng Li, Xiao Li, Wenwen Huang, Liqiong Wang, Xiaofang Bi, Libing Hu, Yang Yang, Yingbao Wang, Rui Gong…
    Citation: Journal of Translational Medicine 2023 21:475
  35. The glycosyltransferase CHSY3 is a CHSY family member, yet its importance in the context of gastric cancer development remains incompletely understood. The present study was thus developed to explore the mecha...

    Authors: Xinkun Huang, Yonghui Liu, Chenyu Qian, Qicheng Shen, Menglong Wu, Bin Zhu and Ying Feng
    Citation: Journal of Translational Medicine 2023 21:474
  36. Epithelial ovarian cancer is the leading cause of death from gynecologic cancer, in which serous ovarian carcinoma (SOC) is the most common histological subtype. Although PARP inhibitors (PARPi) and antiangiog...

    Authors: Xiaohui Yang, Minying Zheng, Yidi Ning, Jie Sun, Yongjun Yu and Shiwu Zhang
    Citation: Journal of Translational Medicine 2023 21:456
  37. USP51 is a deubiquitinase (DUB), that is involved in diverse cellular processes. Accumulating evidence has demonstrated that USP51 contributes to cancer development. However, its impact on non-small cell lung ...

    Authors: Jin Chen, Zhongqiu Wu, Wenyi Deng, Minying Tang, Lvying Wu, Na Lin, Liuyan Chen, Yunfeng Fu, Min Zhao, Changguo Chen and Wenting Li
    Citation: Journal of Translational Medicine 2023 21:453
  38. Aberrant ubiquitin-proteasome system (UPS) triggers various disorders of biological events and contributes to progression of tumorigenesis. The tripartite motif containing 22 (TRIM22) was demonstrated to parti...

    Authors: Xiaoli Gu, Wei Min, Yibin Zeng, Ni Fan and Qihong Qian
    Citation: Journal of Translational Medicine 2023 21:443
  39. Intra-tumoral heterogeneity (ITH) is a distinguished hallmark of cancer, and cancer stem cells (CSCs) contribute to this malignant characteristic. Therefore, it is of great significance to investigate and even...

    Authors: Runtian Wang, Kun Xu, Qin Chen, Qin Hu, Jian Zhang and Xiaoxiang Guan
    Citation: Journal of Translational Medicine 2023 21:409
  40. Insulin like growth factor II mRNA binding protein 3 (IGF2BP3) is an RNA binding protein with multiple roles in regulation of gene expression at the post-transcriptional level and is implicated in tumorigenesi...

    Authors: Feifei Yang, Qiang Ma, Bo Huang, Xiaolin Wang, Xiaojuan Pan, Ting Yu, Lingyu Ran, Shan Jiang, Haiping Li, Ye Chen, Yuying Liu, Ce Liang, Junwu Ren, Yuying Zhang, Shimin Wang, Wei Li…
    Citation: Journal of Translational Medicine 2023 21:402
  41. Bone marrow metastasis (BMM) is underestimated in gastric cancer (GC). GC with BMM frequently complicate critical hematological abnormalities like diffused intravascular coagulation and microangiopathic hemoly...

    Authors: Caiqin Wang, Bo Xie, Shi Yin, Jianghua Cao, Junhao Huang, Longyang Jin, Ge Du, Xiaohui Zhai, Rongqin Zhang, Shanshan Li, Taiyuan Cao, Hongen Yu, Xinjuan Fan, Zuli Yang, Junsheng Peng, Jian Xiao…
    Citation: Journal of Translational Medicine 2023 21:399
  42. Ovarian cancer (OC) has high mortality and poor prognosis for lacking of specific biomarkers and typical clinical symptoms in the early stage. CEBPG is an important regulator in tumor development, yet it is un...

    Authors: Xiaoqian Zhang, Xiaocui Zheng, Xiang Ying, Weiwei Xie, Yujia Yin and Xipeng Wang
    Citation: Journal of Translational Medicine 2023 21:334
  43. Pancreatic ductal adenocarcinoma (PDAC) has a low survival, its incidence is rising and little therapeutic improvements are expected in the near future. It has been observed that Epithelial-to-Mesenchymal tran...

    Authors: Jos van Pelt, Bob Meeusen, Rita Derua, Liesbeth Guffens, Eric Van Cutsem, Veerle Janssens and Chris Verslype
    Citation: Journal of Translational Medicine 2023 21:317
  44. Gallbladder cancer (GBC) is the most prevalent and invasive biliary tract malignancy. As a GTPase-activating protein, Neurofibromin 1 (NF1) is a tumor suppressor that negatively regulates the RAS signaling pat...

    Authors: Lingxiao Zhang, Lin Jiang, Ling Zeng, Zhaohui Jin, Xuanjia Dong, Yuhan Zhang, Litian Chen, Yijun Shu, Yingbin Liu and Ying Huang
    Citation: Journal of Translational Medicine 2023 21:306
  45. Metastatic prostate cancer (mPCa) has a poor prognosis with limited treatment options. The high mobility of tumor cells is the key driving characteristic of metastasis. However, the mechanism is complex and fa...

    Authors: Zean Li, Yiran Tao, Ze Gao, Shirong Peng, Yiming Lai, Kaiwen Li, Xu Chen and Hai Huang
    Citation: Journal of Translational Medicine 2023 21:303
  46. Epithelial-to-mesenchymal transition (EMT) and cancer stem-like cells (CSLCs) play crucial role in tumor metastasis and drug-resistance. Disheveled3 (DVL3) is involved in malignant behaviors of cancer. However...

    Authors: Zhengguang Li, Zhirong Yang, Wei Liu, Wanglong Zhu, Lan Yin, Zhenyu Han, Yu Xian, Jie Wen, Hualong Tang, Xinyue Lin, Yuhan Yang, Jingyi Wang and Kun Zhang
    Citation: Journal of Translational Medicine 2023 21:302
  47. Osteosarcoma is a type of bone cancer that predominantly affects young individuals, including children and adolescents. The disease progresses through heterogeneous genetic alterations, and patients often deve...

    Authors: Ravi Chauhan, Ashna Gupta, Lakshay Malhotra, Ajaz A. Bhat, Raj K. Pandita, Tariq Masoodi, Gunjan Dagar, Hana Q. Sadida, Sara K. Al-Marzooqi, Atul Batra, Sameer Bakhshi, Mehar Chand Sharma, Pranay Tanwar, Shah Alam Khan, Ethayathulla Abdul Samath, Shahab Uddin…
    Citation: Journal of Translational Medicine 2023 21:286
  48. The primary cilia (PC) is a microtubule-based and nonmotile organelle which protrudes from the surface of almost all mammalian cells. At present, PC has been found to be a deficiency or loss in multiple cancer...

    Authors: Jingxian Li, Yuanjiong Qi, Bo Li, Yan Liu, Kuo Yang, Zhihong Zhang, Jianqiang Zhu and E. Du
    Citation: Journal of Translational Medicine 2023 21:281
  49. Oral squamous cell carcinoma (OSCC), an HPV-negative head and neck cancer, frequently metastasizes to the regional lymph nodes but only occasionally beyond. Initial phases of metastasis are associated with an ...

    Authors: Kai Horny, Christoph Sproll, Lukas Peiffer, Frauke Furtmann, Patricia Gerhardt, Jan Gravemeyer, Nikolas H. Stoecklein, Ivelina Spassova and Jürgen C. Becker
    Citation: Journal of Translational Medicine 2023 21:267