Medical bioinformatics

Section edited by Samir K. Brahmachari

The explosion of genome sequencing data along with genotype to phenotype correlation studies has created data deluge in the area of biomedical sciences. The aim of the Medical bioinformatics section is to aid the development and maturation of the field by providing a platform for the translation of these datasets into useful clinical applications. The increase in computing capabilities and availability of different data from advanced technologies will allow researchers to build System Biology models of various diseases in order to efficiently develop new therapeutic interventions and reduce the current prohibitively large costs of drug discovery.

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  1. Research

    Statistically controlled identification of differentially expressed genes in one-to-one cell line comparisons of the CMAP database for drug repositioning

    The Connectivity Map (CMAP) database, an important public data source for drug repositioning, archives gene expression profiles from cancer cell lines treated with and without bioactive small molecules. Howeve...

    Jun He, Haidan Yan, Hao Cai, Xiangyu Li, Qingzhou Guan, Weicheng Zheng, Rou Chen, Huaping Liu, Kai Song, Zheng Guo and Xianlong Wang

    Journal of Translational Medicine 2017 15:198

    Published on: 29 September 2017

  2. Research

    Antibiotics-induced depletion of mice microbiota induces changes in host serotonin biosynthesis and intestinal motility

    The gastrointestinal motility is affected by gut microbiota and the relationship between them has become a hot topic. However, mechanisms of microbiota in regulating motility have not been well defined. We thu...

    Xiaolong Ge, Chao Ding, Wei Zhao, Lizhi Xu, Hongliang Tian, Jianfeng Gong, Minsheng Zhu, Jieshou Li and Ning Li

    Journal of Translational Medicine 2017 15:13

    Published on: 13 January 2017

  3. Research

    Prediction of anti-inflammatory proteins/peptides: an insilico approach

    The current therapy for inflammatory and autoimmune disorders involves the use of nonspecific anti-inflammatory drugs and other immunosuppressant, which are often accompanied with potential side effects. As an...

    Sudheer Gupta, Ashok K. Sharma, Vibhuti Shastri, Midhun K. Madhu and Vineet K. Sharma

    Journal of Translational Medicine 2017 15:7

    Published on: 6 January 2017

  4. Research

    Guizhi-Shaoyao-Zhimu decoction attenuates rheumatoid arthritis partially by reversing inflammation-immune system imbalance

    Guizhi-Shaoyao-Zhimu decoction (GSZD) has been extensively used for rheumatoid arthritis (RA) therapy. Marked therapeutic efficacy of GSZD acting on RA has been demonstrated in several long-term clinical trial...

    Qiuyan Guo, Xia Mao, Yanqiong Zhang, Shuqin Meng, Yue Xi, Yi Ding, Xiaocun Zhang, Yuntao Dai, Xia Liu, Chao Wang, Yuting Li and Na Lin

    Journal of Translational Medicine 2016 14:165

    Published on: 8 June 2016

  5. Review

    Regulatory mechanisms of microRNA expression

    MicroRNAs (miRs, miRNAs) are small molecules of 18–22 nucleotides that serve as important regulators of gene expression at the post-transcriptional level. One of the mechanisms through which miRNAs regulate ge...

    Lyudmila F. Gulyaeva and Nicolay E. Kushlinskiy

    Journal of Translational Medicine 2016 14:143

    Published on: 20 May 2016

  6. Research

    Development and validation of new glomerular filtration rate predicting models for Chinese patients with type 2 diabetes

    Previous researches has depicted that the performance of the recommended glomerular filtration rate (GFR)-estimating equations in the type 2 diabetic population is inferior to that in the non-diabetic populati...

    Jinxia Chen, Hua Tang, Hui Huang, Linsheng Lv, Yanni Wang, Xun Liu and Tanqi Lou

    Journal of Translational Medicine 2015 13:317

    Published on: 28 September 2015

  7. Research

    Comparative study of anti-angiogenic activities of luteolin, lectin and lupeol biomolecules

    Angiogenesis is a hallmark feature in the initiation, progression and growth of tumour. There are various factors for promotion of angiogenesis on one hand and on the other hand, biomolecules have been report...

    Rashmi K. Ambasta, Saurabh Kumar Jha, Dhiraj Kumar, Renu Sharma, Niraj Kumar Jha and Pravir Kumar

    Journal of Translational Medicine 2015 13:307

    Published on: 18 September 2015

  8. Research

    miFRame: analysis and visualization of miRNA sequencing data in neurological disorders

    While in the past decades nucleic acid analysis has been predominantly carried out using quantitative low- and high-throughput approaches such as qRT-PCR and microarray technology, next-generation sequencing (...

    Christina Backes, Jan Haas, Petra Leidinger, Karen Frese, Thomas Großmann, Klemens Ruprecht, Benjamin Meder, Eckart Meese and Andreas Keller

    Journal of Translational Medicine 2015 13:224

    Published on: 14 July 2015

  9. Research

    Systems level mapping of metabolic complexity in Mycobacterium tuberculosis to identify high-value drug targets

    The effectiveness of current therapeutic regimens for Mycobacterium tuberculosis (Mtb) is diminished by the need for prolonged therapy and the rise of drug resistant/tolerant strains. This global health threat, d...

    Rohit Vashisht, Ashwini G Bhat, Shreeram Kushwaha, Anshu Bhardwaj, OSDD Consortium and Samir K Brahmachari

    Journal of Translational Medicine 2014 12:263

    Published on: 11 October 2014

  10. Research

    Identification of candidate miRNA biomarkers from miRNA regulatory network with application to prostate cancer

    MicroRNAs (miRNAs) are a class of non-coding regulatory RNAs approximately 22 nucleotides in length that play a role in a wide range of biological processes. Abnormal miRNA function has been implicated in vari...

    Wenyu Zhang, Jin Zang, Xinhua Jing, Zhandong Sun, Wenying Yan, Dongrong Yang, Feng Guo and Bairong Shen

    Journal of Translational Medicine 2014 12:66

    Published on: 11 March 2014

  11. Meeting report

    Dry computational approaches for wet medical problems

    This is a report on the 4th international conference in ‘Quantitative Biology and Bioinformatics in Modern Medicine’ held in Belfast (UK), 19–20 September 2013. The aim of the conference was to bring together ...

    Frank Emmert-Streib, Shu-Dong Zhang and Peter Hamilton

    Journal of Translational Medicine 2014 12:26

    Published on: 25 January 2014

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