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Patient-targeted molecular therapies

Section edited by Francesco Chiappelli and Francesco Piva

The mission of this section is to enrich the overall mandate of the journal through effectively capturing the growing sector of molecular targeted therapies with broad therapeutic applicability, benefiting from a patient-centered outcomes research focus and translational effectiveness approach, to generate adequate information during research and early development stages, as well as consensus on the best available evidence.

This section has a unique and defining objective and rationale relative to the other sections that focus primarily on translational immunology and oncology. In contrast, this section will add the complementary discourse between translational research and translational effectiveness. In doing so, it will expand the overall vision of the journal, and address current, timely and cutting edge research and reviews about patient-centered targeted therapies, in context of translating cost and benefit effectiveness to specific clinical settings.

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  1. Content type: Research

    Periodontitis is an infectious disease that manifests as alveolar bone loss surrounding the roots of teeth. Diabetes aggravates periodontitis-induced alveolar bone loss via suppression of bone formation. Inter...

    Authors: Ji-Hye Kim, Ae Ri Kim, Yun Hui Choi, Aeryun Kim, Yongsung Sohn, Gye-Hyeong Woo, Jeong-Heon Cha, Eun-Jung Bak and Yun-Jung Yoo

    Citation: Journal of Translational Medicine 2018 16:70

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  2. Content type: Research

    Around 30% of patients with inflammatory bowel disease (IBD) are refractory to current IBD drugs or relapse over time. Novel treatments are called for, and low dose Naltrexone (LDN) may provide a safe, easily ...

    Authors: Mitchell R. K. L. Lie, Janine van der Giessen, Gwenny M. Fuhler, Alison de Lima, Maikel P. Peppelenbosch, Cokkie van der Ent and C. Janneke van der Woude

    Citation: Journal of Translational Medicine 2018 16:55

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  3. Content type: Research

    We investigated antitumor activity and underlying mechanisms of DNA topoisomerase I (TopI) inhibitor gimatecan and irinotecan in gastric cancer (GC) in vitro cell lines and in vivo patient-derived xenograft (P...

    Authors: Zuhua Chen, Zhentao Liu, Wenwen Huang, Zhongwu Li, Jianling Zou, Jingyuan Wang, Xiaoting Lin, Beifang Li, Dongshao Chen, Yanting Hu, Jiafu Ji, Jing Gao and Lin Shen

    Citation: Journal of Translational Medicine 2017 15:253

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  4. Content type: Research

    About 10–15% of adult, and most pediatric, gastrointestinal stromal tumors (GIST) lack mutations in KIT, PDGFRA, SDHx, or RAS pathway components (KRAS, BRAF, NF1). The identification of additional mutated gene...

    Authors: Eileen Shi, Juliann Chmielecki, Chih-Min Tang, Kai Wang, Michael C. Heinrich, Guhyun Kang, Christopher L. Corless, David Hong, Katherine E. Fero, James D. Murphy, Paul T. Fanta, Siraj M. Ali, Martina De Siena, Adam M. Burgoyne, Sujana Movva, Lisa Madlensky…

    Citation: Journal of Translational Medicine 2016 14:339

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  5. Content type: Research

    Pancreatic acinar cell carcinoma (PACC) is a rare malignancy, accounting for <1 % of all pancreatic neoplasms. Very few retrospective studies are available to help guide management. We previously reported the ...

    Authors: Jason C. Hall, Laura A. Marlow, Adam C. Mathias, Louis K. Dawson, William F. Durham, Kenneth A. Meshaw, Robert J. Mullin, Aidan J. Synnott, Daniel L. Small, Murli Krishna, Daniel von Hoff, Julia Schüler, Steven N. Hart, Fergus J. Couch, Gerardo Colon-Otero and John A. Copland

    Citation: Journal of Translational Medicine 2016 14:129

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  6. Content type: Research

    Leiomyosarcoma (LMS) is a common type of soft tissue sarcoma that responds poorly to standard chemotherapy. Thus the goal of this study was to identify novel selective therapies that may be effective in leiomy...

    Authors: Yael Babichev, Leah Kabaroff, Alessandro Datti, David Uehling, Methvin Isaac, Rima Al-awar, Michael Prakesch, Ren X. Sun, Paul C. Boutros, Rosemarie Venier, Brendan C. Dickson and Rebecca A. Gladdy

    Citation: Journal of Translational Medicine 2016 14:67

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  7. Content type: Research

    Protein arginine methyltransferase 5 (PRMT5), a type II PRMT, is highly expressed in some tumors, but its role in hepatocellular carcinoma (HCC) is still unknown.

    Authors: Baolai Zhang, Shuhong Dong, Zhongxin Li, Li Lu, Su Zhang, Xue Chen, Xiaobo Cen and Yongjie Wu

    Citation: Journal of Translational Medicine 2015 13:349

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  8. Content type: Research

    The STAT3 transcription factor is a major intracellular signaling protein and is frequently dysregulated in the most common and lethal brain malignancy in adults, glioblastoma multiforme (GBM). Activation of ...

    Authors: Rajesh Mukthavaram, Xiao Ouyang, Rohit Saklecha, Pengfei Jiang, Natsuko Nomura, Sandeep C Pingle, Fang Guo, Milan Makale and Santosh Kesari

    Citation: Journal of Translational Medicine 2015 13:269

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  9. Content type: Research

    Although targeted therapies have improved the clinical outcomes of cancer treatment, tumors resistance to targeted drug are often detected too late and cause mortality. CSE1L is secreted from tumor and its pho...

    Authors: Woan-Ruoh Lee, Shing-Chuan Shen, Yi-Hsien Shih, Chia-Lun Chou, Jonathan Te-Peng Tseng, Szu-Ying Chin, Kao-Hui Liu, Yen-Chou Chen and Ming-Chung Jiang

    Citation: Journal of Translational Medicine 2015 13:191

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  10. Content type: Research

    Ganglioglioma (GG) and pilocytic astrocytoma (PA) represent the most frequent low-grade gliomas (LGG) occurring in paediatric age. LGGs not amenable of complete resection (CR) represent a challenging subgroup ...

    Authors: Francesca del Bufalo, Andrea Carai, Lorenzo Figà-Talamanca, Benedetta Pettorini, Conor Mallucci, Felice Giangaspero, Manila Antonelli, Manuela Badiali, Loredana Moi, Giuseppe Bianco, Antonella Cacchione, Franco Locatelli, Elisabetta Ferretti and Angela Mastronuzzi

    Citation: Journal of Translational Medicine 2014 12:356

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  11. Content type: Methodology

    Saliva has long been used as a sampling source for clinical diagnosis of oral disease such as oral squamous cell carcinoma, or therapeutic drug monitoring. The aims of this study was to ascertain if saliva RNA...

    Authors: Dongmei Chen, Najie Song, Runfang Ni, Jiangning Zhao, Jiasheng Hu, Quanyi Lu and Qingge Li

    Citation: Journal of Translational Medicine 2014 12:321

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  12. Content type: Research

    The KRAS oncogene was one of the earliest discoveries of genetic alterations in colorectal and lung cancers. Moreover, KRAS somatic mutations might be used for predicting the efficiency of anti-EGFR therapeutic d...

    Authors: Ming-Yii Huang, Hsueh-Chiao Liu, Li-Chen Yen, Jia-Yuan Chang, Jian-Jhang Huang, Jaw-Yuan Wang, Chao-Peng Hsiao and Shiu-Ru Lin

    Citation: Journal of Translational Medicine 2014 12:147

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  13. Content type: Review

    In the post-genomic era, it has become evident that genetic changes alone are not sufficient to understand most disease processes including pancreatic cancer. Genome sequencing has revealed a complex set of ge...

    Authors: Daniel Ansari, Linus Aronsson, Agata Sasor, Charlotte Welinder, Melinda Rezeli, György Marko-Varga and Roland Andersson

    Citation: Journal of Translational Medicine 2014 12:87

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  14. Content type: Research

    Medulloepithelioma (ME) is a rare embryonal tumor predominantly located in the eye or in the central nervous system without an established treatment.

    Authors: Maria Debora De Pasquale, Maria Antonietta De Ioris, Angela Gallo, Angela Mastronuzzi, Alessandro Crocoli, Raffaele Cozza and Renata Boldrini

    Citation: Journal of Translational Medicine 2014 12:49

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  15. Content type: Research

    PRL-3 is a member of phosphatases of regenerating liver family, characterized by phosphatase active domain and C-terminal prenylation motif. Overexpression of PRL-3 has been implicated in multiple cancers. Her...

    Authors: Xiaofang Xing, Shenyi Lian, Ying Hu, Ziyu Li, Lianhai Zhang, Xianzi Wen, Hong Du, Yongning Jia, Zhixue Zheng, Lin Meng, Chengchao Shou and Jiafu Ji

    Citation: Journal of Translational Medicine 2013 11:309

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    The Erratum to this article has been published in Journal of Translational Medicine 2014 12:73

  16. Content type: Research

    Rho GTPases play important roles in cytoskeleton organization, cell cycle progression and are key regulators of tumor progression. Strategies to modulate increased Rho GTPase activities during cancer progressi...

    Authors: Karin Zins, Sandun Gunawardhana, Trevor Lucas, Dietmar Abraham and Seyedhossein Aharinejad

    Citation: Journal of Translational Medicine 2013 11:295

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  17. Content type: Research

    Triple-negative breast cancer (TNBC) is an aggressive clinical subtype of breast cancer that is characterized by the lack of estrogen receptor (ER) and progesterone receptor (PR) expression as well as human ep...

    Authors: Birdal Bilir, Omer Kucuk and Carlos S Moreno

    Citation: Journal of Translational Medicine 2013 11:280

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  18. Content type: Research

    Effective eradication of high-risk primary prostate cancer (HRPCa) could significantly decrease mortality from prostate cancer. However, the discovery of curative therapies for HRPCa is hampered by the lack of...

    Authors: Hongjuan Zhao, Alan Thong, Rosalie Nolley, Stephen W Reese, Jennifer Santos, Alexandre Ingels and Donna M Peehl

    Citation: Journal of Translational Medicine 2013 11:199

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  19. Content type: Research

    Flotillin-2 (FLOT2) has been implicated in several signaling pathways in tumor cells. Our study aimed to investigate the expression pattern and clinicopathological significance of FLOT2 in patients with breast...

    Authors: Xi Wang, Qi Yang, Ling Guo, Xing-Hua Li, Xiao-Hui Zhao, Li-Bing Song and Huan-Xin Lin

    Citation: Journal of Translational Medicine 2013 11:190

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