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Cell Death and Senescence

Section edited by Lorenzo Gullazzi and Melissa Myint

© © ipopba / Getty Images / iStockThis section aims to to provide a platform for research on cell death and senescence. Dysfunctions in the molecular and cellular mechanisms through which individual eukaryotic cells respond to stress (either successfully or not) and interact with their host in the process, including (but not limited to) the DNA damage response, the unfolded protein response, autophagy, RCD and cellular senescence have been attributed pathological significance in a plethora of human disorders

This section welcomes original research contributions, review articles, and commentaries discussing mechanistic and pathophysiological aspects of these processes. 

  1. Cardiac fibrosis after myocardial infarction (MI) has been considered an important part of cardiac pathological remodeling. Immune cells, especially macrophages, are thought to be involved in the process of fi...

    Authors: Da Ke, Mingzhen Cao, Jian Ni, Yuan Yuan, Jiangyang Deng, Si Chen, Xiujun Dai and Heng Zhou
    Citation: Journal of Translational Medicine 2024 22:560
  2. The aging process of the kidneys is accompanied with several structural diseases. Abnormal fiber formation disrupts the balance of kidney structure and function, causing to end-stage renal disease and subseque...

    Authors: Ren Ji, Lin Wei, Yuxin Zan, Xiao Li, Shinan Ma, Liming Ma, Xiju He, Li Wang and Yan Ding
    Citation: Journal of Translational Medicine 2024 22:514
  3. To analyze the role of and mechanism underlying obstructive sleep apnea (OSA)-derived exosomes in inducing non-alcoholic fatty liver (NAFLD).

    Authors: Li Yang, Shijie Liu, Yan He, Lulu Gan, Qing Ni, Anni Dai, Changhuan Mu, Qian Liu, Hongyan Chen, Hongying Lu and Ruixue Sun
    Citation: Journal of Translational Medicine 2024 22:475
  4. Microtubule targeting agents (MTAs) are commonly prescribed to treat cancers and predominantly kill cancer cells in mitosis. Significantly, some MTA-treated cancer cells escape death in mitosis, exit mitosis a...

    Authors: Juan Jesus Vicente, Kainat Khan, Grant Tillinghast, José L. McFaline-Figueroa, Yasemin Sancak and Nephi Stella
    Citation: Journal of Translational Medicine 2024 22:441
  5. With the aging global population, type 2 diabetes mellitus (T2DM) and osteoporosis(OP) are becoming increasingly prevalent. Diabetic osteoporosis (DOP) is a metabolic bone disorder characterized by abnormal bo...

    Authors: Yili Chen, Wen Zhao, An Hu, Shi Lin, Ping Chen, Bing Yang, Zhirong Fan, Ji Qi, Wenhui Zhang, Huanhuan Gao, Xiubing Yu, Haiyun Chen, Luyuan Chen and Haizhou Wang
    Citation: Journal of Translational Medicine 2024 22:409
  6. Lung adenocarcinoma (LUAD), the most common and lethal subtype of lung cancer, continues to be a major health concern worldwide. Despite advances in targeted and immune therapies, only a minority of patients d...

    Authors: Zizhen Li, Wenhua Lu, Feng Yin, Peiting Zeng, Heping Li and Amin Huang
    Citation: Journal of Translational Medicine 2024 22:340
  7. Peripheral nerve injury (PNI) is commonly observed in clinical practice, yet the underlying mechanisms remain unclear. This study investigated the correlation between the expression of a Ras-related protein Ra...

    Authors: Jiayi Wang, Pin Chen, Guanjie Han, Yongjie Zhou, Xingdong Xiang, Mengxuan Bian, Lei Huang, Xiang Wang, Binfeng He and Shunyi Lu
    Citation: Journal of Translational Medicine 2024 22:194
  8. Radiotherapy can induce tumor cell autophagy, which might impair the antitumoral effect. This study aims to investigate the effect of autophagy inhibition on the targeted radionuclide therapy (TRT) efficacy of 13...

    Authors: Xingyu Liu, Danni Li, Tianbao Ma, Xiu Luo, Ye Peng, Tao Wang, Changjing Zuo and Jianming Cai
    Citation: Journal of Translational Medicine 2024 22:156
  9. Oxaliplatin resistance usually leads to therapeutic failure and poor prognosis in colorectal cancer (CRC), while the underlying mechanisms are not yet fully understood. Metabolic reprogramming is strongly link...

    Authors: Yuting Huang, Szehoi Chan, Shuna Chen, Xueqi Liu, Miao Li, Liyuan Zheng, Zhaoxia Dong, Ziyi Yang, Zixuan Liu, Disheng Zhou, Xingding Zhang and Bo Zhang
    Citation: Journal of Translational Medicine 2024 22:133
  10. (Pro)renin receptor (PRR) is highly expressed in renal tubules, which is involved in physiological and pathological processes. However, the role of PRR, expressed in renal tubular epithelial cells, in diabetic...

    Authors: Shiying Xie, Shicong Song, Sirui Liu, Qiong Li, Wei Zou, Jianting Ke and Cheng Wang
    Citation: Journal of Translational Medicine 2024 22:26
  11. Inflammatory response has been recognized as a pivotal pathophysiological process during cerebral ischemia. ChemR23 signaling is involved in the pathophysiology of various inflammatory diseases. Nevertheless, ...

    Authors: Lan Liu, Jiawei Zhang, Kaili Lu, Yaxuan Zhang, Xiaofeng Xu, Jiangshan Deng, Xiaojie Zhang, Haibing Zhang, Yuwu Zhao and Xiuzhe Wang
    Citation: Journal of Translational Medicine 2024 22:23
  12. Epigenetic regulation is reported to play a significant role in the pathogenesis of various kidney diseases, including renal cell carcinoma, acute kidney injury, renal fibrosis, diabetic nephropathy, and lupus...

    Authors: Xinzhou Yan, Yuqi Xia, Bojun Li, Zehua Ye, Lei Li, Tianhui Yuan, Baofeng Song, Weimin Yu, Ting Rao, Jinzhuo Ning, Fangyou Lin, Shuqin Mei, Zhiguo Mao, Xiangjun Zhou, Wei Li and Fan Cheng
    Citation: Journal of Translational Medicine 2024 22:9
  13. Mounting attention has been focused on defects of the autophagy-lysosomal pathway in sepsis, however, the precise mechanisms governing the autophagy-lysosomal process in sepsis are poorly known. We have previo...

    Authors: Qing Fang, Guoqing Jing, Ying Zhang, Hongyu Wang, Huan Luo, Yun Xia, Qiyan Jin, Yuping Liu, Jing Zuo, Cheng Yang, Xiaodong Zhang, Shi Liu, Xiaojing Wu and Xuemin Song
    Citation: Journal of Translational Medicine 2023 21:916
  14. The identifying of B-cell lymphoma 2 (Bcl-2) as a therapeutic target has led to a paradigm shift in acute myeloid leukemia (AML) treatment. Pyroptosis is a novel antitumor therapeutic mechanism due to its cyto...

    Authors: Fanghua Ye, Wen Zhang, Chenying Fan, Jiajia Dong, Min Peng, Wenjun Deng, Hui Zhang and Liangchun Yang
    Citation: Journal of Translational Medicine 2023 21:606