Disease biomarkers

Section edited by Xiangdong Wang

This section aims to bridge the identification and validation of discovered gene or protein-based, network or dynamic network biomarkers with human diseases, patient phenotypes, or clinical applications, and accelerate the development of human disease-specific biomarkers for the early diagnosis, monitoring, evaluation, and prediction of diseases. Conditions including cancers, cardiovascular and metabolic diseases will be the focus of study. This section will promote the innovation and development of disease-specific biomarkers by integrating multidisciplinary aspects of science.

Studies considered for publication include those regarding the development of advanced biotechnologies for biomarker discovery and development, identifying biomarkers associated with the early detection of diseases, monitoring of disease severity and duration as well as patient responses to therapies, prediction of patient outcomes and the evaluation, regulation and ethics of disease biomarkers.

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  1. Research

    Quantification of mutant SPOP proteins in prostate cancer using mass spectrometry-based targeted proteomics

    Speckle-type POZ protein (SPOP) is an E3 ubiquitin ligase adaptor protein that functions as a potential tumor suppressor, and SPOP mutations have been identified in ~10% of human prostate cancers. However, it ...

    Hui Wang, Christopher E. Barbieri, Jintang He, Yuqian Gao, Tujin Shi, Chaochao Wu, Athena A. Schepmoes, Thomas L. Fillmore, Sung-Suk Chae, Dennis Huang, Juan Miguel Mosquera, Wei-Jun Qian, Richard D. Smith, Sudhir Srivastava, Jacob Kagan, David G. Camp II…

    Journal of Translational Medicine 2017 15:175

    Published on: 15 August 2017

  2. Research

    Proteomic analysis of sputum reveals novel biomarkers for various presentations of asthma

    It is now recognized that asthma can present in different forms. Typically, asthma present with symptoms of wheeze, breathlessness and cough. Atypical forms of asthma such as cough variant asthma (CVA) or che...

    Chao Cao, Wen Li, Wen Hua, Fugui Yan, Hao Zhang, Huaqiong Huang, Yinghua Ying, Na Li, Fen Lan, Shaobin Wang, Xiao Chen, Jing Li, Jinkai Liu, Tianwen Lai, Zhengqiang Bao, Yuan Cao…

    Journal of Translational Medicine 2017 15:171

    Published on: 4 August 2017

  3. Research

    Survival impact of pre-treatment neutrophils on oropharyngeal and laryngeal cancer patients undergoing definitive radiotherapy

    Squamous cell carcinoma of the head and neck (HNSCC) represents an array of disease processes with a generally unfavorable prognosis. Inflammation plays an important role in tumor development and response to t...

    Whitney A. Sumner, William A. Stokes, Ayman Oweida, Kiersten L. Berggren, Jessica D. McDermott, David Raben, Diana Abbott, Bernard Jones, Gregory Gan and Sana D. Karam

    Journal of Translational Medicine 2017 15:168

    Published on: 2 August 2017

  4. Research

    Comparative analysis of the EGFR, HER2, c-MYC, and MET variations in colorectal cancer determined by three different measures: gene copy number gain, amplification status and the 2013 ASCO/CAP guideline criterion for HER2 testing of breast cancer

    The purpose of this study was to explore gene copy number (GCN) variation of EGFR, HER2, c-MYC, and MET in patients with primary colorectal cancer (CRC).

    Yoonjin Kwak, Sumi Yun, Soo Kyung Nam, An Na Seo, Kyu Sang Lee, Eun Shin, Heung-Kwon Oh, Duck Woo Kim, Sung Bum Kang, Woo Ho Kim and Hye Seung Lee

    Journal of Translational Medicine 2017 15:167

    Published on: 1 August 2017

  5. Review

    The European ME/CFS Biomarker Landscape project: an initiative of the European network EUROMENE

    Myalgic encephalomyelitis or chronic fatigue syndrome (ME/CFS) is a common and severe disease with a considerable social and economic impact. So far, the etiology is not known, and neither a diagnostic marker ...

    Carmen Scheibenbogen, Helma Freitag, Julià Blanco, Enrica Capelli, Eliana Lacerda, Jerome Authier, Mira Meeus, Jesus Castro Marrero, Zaiga Nora-Krukle, Elisa Oltra, Elin Bolle Strand, Evelina Shikova, Slobodan Sekulic and Modra Murovska

    Journal of Translational Medicine 2017 15:162

    Published on: 26 July 2017

  6. Research

    High expression of ETS2 predicts poor prognosis in acute myeloid leukemia and may guide treatment decisions

    ETS2 is a downstream effector of the RAS/RAF/ERK pathway, which plays a critical role in the development of malignant tumor. However, the clinical impact of ETS2 expression in AML rema...

    Lin Fu, Huaping Fu, Qingyun Wu, Yifan Pang, Keman Xu, Lei Zhou, Jianlin Qiao, Xiaoyan Ke, Kailin Xu and Jinlong Shi

    Journal of Translational Medicine 2017 15:159

    Published on: 19 July 2017

  7. Research

    Identification of clear cell renal cell carcinoma and oncocytoma using a three-gene promoter methylation panel

    Promoter methylation has emerged as a promising class of epigenetic biomarkers for diagnosis and prognosis of renal cell tumors (RCTs). Although differential gene promoter methylation patterns have been report...

    Ana Sílvia Pires-Luís, Pedro Costa-Pinheiro, Maria João Ferreira, Luís Antunes, Francisco Lobo, Jorge Oliveira, Rui Henrique and Carmen Jerónimo

    Journal of Translational Medicine 2017 15:149

    Published on: 29 June 2017

  8. Research

    Development of an objective gene expression panel as an alternative to self-reported symptom scores in human influenza challenge trials

    Influenza challenge trials are important for vaccine efficacy testing. Currently, disease severity is determined by self-reported scores to a list of symptoms which can be highly subjective. A more objective m...

    Julius Muller, Eneida Parizotto, Richard Antrobus, James Francis, Campbell Bunce, Amanda Stranks, Marshall Nichols, Micah McClain, Adrian V. S. Hill, Adaikalavan Ramasamy and Sarah C. Gilbert

    Journal of Translational Medicine 2017 15:134

    Published on: 8 June 2017

  9. Research

    Distinct expression profile of HCMV encoded miRNAs in plasma from oral lichen planus patients

    Oral lichen planus (OLP) is a T cell-mediated autoimmune disease. The aetiology and molecular mechanisms of OLP remain unclear. Human cytomegalovirus (HCMV) infection is a causal factor in the development of v...

    Meng Ding, Xiang Wang, Cheng Wang, Xiaoshuang Liu, Ke Zen, Wenmei Wang, Chen-Yu Zhang and Chunni Zhang

    Journal of Translational Medicine 2017 15:133

    Published on: 7 June 2017

  10. Research

    Osteoclast profile of medication-related osteonecrosis of the jaw secondary to bisphosphonate therapy: a comparison with osteoradionecrosis and osteomyelitis

    The medication-related osteonecrosis of the jaw secondary to bisphosphonate therapy [MRONJ (BP)] is characterized by non-healing exposed bone in the maxillofacial region. The pathogenesis of MRONJ (BP) is not ...

    Christian Gross, Manuel Weber, Kay Creutzburg, Patrick Möbius, Raimund Preidl, Kerstin Amann and Falk Wehrhan

    Journal of Translational Medicine 2017 15:128

    Published on: 6 June 2017

  11. Research

    Distinct pathophysiological cytokine profiles for discrimination between autoimmune pancreatitis, chronic pancreatitis, and pancreatic ductal adenocarcinoma

    Discriminating between autoimmune pancreatitis (AIP), chronic pancreatitis (CP), and pancreatic ductal adenocarcinoma (PDAC) can be challenging. In this retrospective study, levels of serum and tissue cytokine...

    Sahar Ghassem-Zadeh, Matthias M. Gaida, Szilard Szanyi, Hans Acha-Orbea, Jean-Louis Frossard, Ulf Hinz, Thilo Hackert, Oliver Strobel and Klaus Felix

    Journal of Translational Medicine 2017 15:126

    Published on: 2 June 2017

  12. Research

    Aberrant monocyte responses predict and characterize dengue virus infection in individuals with severe disease

    Currently, several assays can diagnose acute dengue infection. However, none of these assays can predict the severity of the disease. Biomarkers that predicts the likelihood that a dengue patient will develop ...

    Yean K. Yong, Hong Y. Tan, Soe Hui Jen, Esaki M. Shankar, Santha K. Natkunam, Jameela Sathar, Rishya Manikam and Shamala D. Sekaran

    Journal of Translational Medicine 2017 15:121

    Published on: 31 May 2017

  13. Research

    Correlation of cell-free DNA plasma concentration with severity of non-alcoholic fatty liver disease

    The assessment of fibrosis and inflammatory activity is essential to identify patients with non-alcoholic fatty liver disease (NAFLD) at risk for progressive disease. Serum markers and ultrasound-based methods...

    Thomas Karlas, Lara Weise, Stephanie Kuhn, Felix Krenzien, Matthias Mehdorn, David Petroff, Nicolas Linder, Alexander Schaudinn, Harald Busse, Volker Keim, Johann Pratschke, Johannes Wiegand, Katrin Splith and Moritz Schmelzle

    Journal of Translational Medicine 2017 15:106

    Published on: 19 May 2017

  14. Research

    Bovis Bacillus Calmette–Guerin (BCG) infection induces exosomal miRNA release by human macrophages

    Tuberculosis (TB) remains a significant global health concern and its diagnosis is challenging due to the limitations in the specificity and sensitivity of the current diagnostic tests. Exosomes are bioactive ...

    Shamila D. Alipoor, Esmaeil Mortaz, Payam Tabarsi, Parissa Farnia, Mehdi Mirsaeidi, Johan Garssen, Masoud Movassaghi and Ian M. Adcock

    Journal of Translational Medicine 2017 15:105

    Published on: 12 May 2017

  15. Research

    Up-regulated expression of substance P in CD8+ T cells and NK1R on monocytes of atopic dermatitis

    Large numbers of CD8+ T cells were observed in atopic dermatitis (AD) skin, and monocytes from AD patients showed increased prostaglandin E2 production. However, little is known about the expression of substance ...

    Zenan Zhang, Wenjiao Zheng, Hua Xie, Ruonan Chai, Junling Wang, Huiyun Zhang and Shaoheng He

    Journal of Translational Medicine 2017 15:93

    Published on: 1 May 2017

  16. Review

    Apoptosis in ischemic heart disease

    Apoptosis plays an important role in the myocardial loss after acute myocardial infarction and participates in the process of subsequent left ventricular remodeling and development of symptomatic heart failure...

    Elena Teringova and Petr Tousek

    Journal of Translational Medicine 2017 15:87

    Published on: 1 May 2017

  17. Research

    Detection of newly produced T and B lymphocytes by digital PCR in blood stored dry on nylon flocked swabs

    A normal number of T-cell receptor excision circles (TRECs) and K-deleting recombination excision circles (KRECs) is considered a biomarker for adequate new T- and B-cell production. In newborns, detection of ...

    Marion Vaglio Tessitore, Alessandra Sottini, Aldo M. Roccaro, Claudia Ghidini, Simona Bernardi, Giovanni Martellosio, Federico Serana and Luisa Imberti

    Journal of Translational Medicine 2017 15:70

    Published on: 5 April 2017

  18. Research

    Association of atrial fibrillation susceptibility genes, atrial fibrillation phenotypes and response to catheter ablation: a gene-based analysis of GWAS data

    Previous studies have suggested PITX2, KCNN3 and ZFHX3 as atrial fibrillation (AF) susceptibility genes. Single common genetic polymorphisms of those genes have been linked with AF phenotypes and rhythm outcome o...

    Daniela Husser, Petra Büttner, Laura Ueberham, Borislav Dinov, Philipp Sommer, Arash Arya, Gerhard Hindricks and Andreas Bollmann

    Journal of Translational Medicine 2017 15:71

    Published on: 5 April 2017

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