Skip to content

Advertisement

Disease biomarkers

Section edited by Xiangdong Wang

This section aims to bridge the identification and validation of discovered gene or protein-based, network or dynamic network biomarkers with human diseases, patient phenotypes, or clinical applications, and accelerate the development of human disease-specific biomarkers for the early diagnosis, monitoring, evaluation, and prediction of diseases. Conditions including cancers, cardiovascular and metabolic diseases will be the focus of study. This section will promote the innovation and development of disease-specific biomarkers by integrating multidisciplinary aspects of science.

Studies considered for publication include those regarding the development of advanced biotechnologies for biomarker discovery and development, identifying biomarkers associated with the early detection of diseases, monitoring of disease severity and duration as well as patient responses to therapies, prediction of patient outcomes and the evaluation, regulation and ethics of disease biomarkers.

Page 1 of 11
  1. Content type: Research

    Nonalcoholic fatty liver disease (NAFLD) is a prevalent complication of extreme obesity. Loading of the liver with fat can progress to inflammation and fibrosis including cirrhosis. The molecular factors invol...

    Authors: Xin Chu, Qunyan Jin, Hui Chen, G. Craig Wood, Anthony Petrick, William Strodel, Jon Gabrielsen, Peter Benotti, Tooraj Mirshahi, David J. Carey, Christopher D. Still, Johanna K. DiStefano and Glenn S. Gerhard

    Citation: Journal of Translational Medicine 2018 16:108

    Published on:

  2. Content type: Research

    Human tissues are invaluable resources for researchers worldwide. Biobanks are repositories of such human tissues and can have a strategic importance for genetic research, clinical care, and future discoveries...

    Authors: Ehsan Ullah, Raghvendra Mall, Reda Rawi, Naima M. Moustaid, Adeel A. Butt and Halima Bensmail

    Citation: Journal of Translational Medicine 2018 16:99

    Published on:

  3. Content type: Research

    Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is clinically defined and characterised by persistent disabling tiredness and exertional malaise, leading to functional impairment.

    Authors: Alice M. Richardson, Don P. Lewis, Badia Kita, Helen Ludlow, Nigel P. Groome, Mark P. Hedger, David M. de Kretser and Brett A. Lidbury

    Citation: Journal of Translational Medicine 2018 16:97

    Published on:

  4. Content type: Research

    Urinary miRNAs may potentially serve as noninvasive biomarkers in various kidney diseases to reflect disease activity, severity and progression, especially those correlated with the pathogenesis of kidney dise...

    Authors: Changming Zhang, Shaoshan Liang, Shuiqin Cheng, Wei Li, Xia Wang, Chunxia Zheng, Caihong Zeng, Shaolin Shi, Lu Xie, Ke Zen and Zhihong Liu

    Citation: Journal of Translational Medicine 2018 16:91

    Published on:

  5. Content type: Review

    Squamous cell carcinoma (SCC) is well-known for its high rate of metastasis with poor prognosis. CD109 is a glycosylphosphatidylinositol-anchored cell-surface glycoprotein. Recently, CD109 emerges as a potenti...

    Authors: Ruixia Qi, Fengyun Dong, Qiang Liu, Yoshiki Murakumo and Ju Liu

    Citation: Journal of Translational Medicine 2018 16:88

    Published on:

  6. Content type: Research

    S100A9 protein, which is recently classified as a novel damage associated molecular pattern, is released from stressed cells undergoing necrosis or secreted by living cells undergoing a stress that act as endo...

    Authors: Rui Wu, Yuhong Zhang, Yu Xiang, Yishu Tang, Fang Cui, Ju Cao, Lan Zhou, Yan You and Liang Duan

    Citation: Journal of Translational Medicine 2018 16:83

    Published on:

  7. Content type: Research

    Telocytes (TCs), a recently discovered novel type of interstitial cells, were also found in a wide variety of human and mammalian reproductive organs/tissues, including uterus, oviduct and placenta. Previously...

    Authors: Xiao-Juan Jiang, Dragos Cretoiu, Zong-Ji Shen and Xiao-Jun Yang

    Citation: Journal of Translational Medicine 2018 16:85

    Published on:

  8. Content type: Research

    Immune checkpoint inhibitors (anti-CTLA-4, anti-PD-1, or the combination) enhance anti-tumor immune responses, yielding durable clinical benefit in several cancer types, including melanoma. However, a subset o...

    Authors: Michael F. Gowen, Keith M. Giles, Danny Simpson, Jeremy Tchack, Hua Zhou, Una Moran, Zarmeena Dawood, Anna C. Pavlick, Shaohui Hu, Melissa A. Wilson, Hua Zhong, Michelle Krogsgaard, Tomas Kirchhoff and Iman Osman

    Citation: Journal of Translational Medicine 2018 16:82

    Published on:

  9. Content type: Research

    Squamous cell carcinoma (SCC) of the conjunctiva is a common cancer in Africa mainly associated with solar ultraviolet (UV) exposure and human immunodeficiency virus (HIV) infection. We analyzed the role of HI...

    Authors: Noemy Starita, Luigi Buonaguro, Franco M. Buonaguro and Maria Lina Tornesello

    Citation: Journal of Translational Medicine 2018 16:77

    Published on:

  10. Content type: Research

    This study addresses whether the association of adiponectin gene (ADIPOQ) variants with idiopathic recurrent pregnancy loss (RPL) is influenced by obesity.

    Authors: Maryam Dendana, Wael Bahia, Ramzi R. Finan, Mariam Al-Mutawa and Wassim Y. Almawi

    Citation: Journal of Translational Medicine 2018 16:76

    Published on:

  11. Content type: Research

    Controversy exists in previous studies on macrophage M1/M2 polarization in chronic obstructive pulmonary disease (COPD). We hypothesized that formyl peptide receptor (FPR), a marker of efferocytosis and mediat...

    Authors: Yung-Che Chen, Meng-Chih Lin, Chih-Hung Lee, Shih-Feng Liu, Chin-Chou Wang, Wen-Feng Fang, Tung-Ying Chao, Chao-Chien Wu, Yu-Feng Wei, Huang-Chih Chang, Chia-Cheng Tsen and Hung-Chen Chen

    Citation: Journal of Translational Medicine 2018 16:69

    Published on:

  12. Content type: Research

    Human neutrophil antigen 3 (HNA-3) is encoded by the SLC44A2 gene. Antibodies against HNAs can cause severe, often fatal, transfusion reactions, known as transfusion-related acute lung injury, and neonatal neu...

    Authors: Guo-Jin Ou, Pin-Can Su, Hao Yu, Xin Ji, Fan Liu, Sheng-Lan Wang, Yu-Jie Kong, Ling Li, Jue Wang, Zhong Liu and Willy Albert Flegel

    Citation: Journal of Translational Medicine 2018 16:67

    Published on:

  13. Content type: Research

    MicroRNAs are of special interest in cancer research and hold significant promise as diagnostic and prognostic biomarkers for malignant disease. MiR-362-5p have been found to exert both oncogenic and tumor sup...

    Authors: Qiu-Ling Ma, Jing-Han Wang, Min Yang, Huan-ping Wang and Jie Jin

    Citation: Journal of Translational Medicine 2018 16:68

    Published on:

  14. Content type: Research

    Circulating microRNAs (miRNAs) are emerging as novel biomarkers for detecting cardiovascular diseases. In this study, we aimed to investigate the usefulness of miRNAs as biomarkers in diagnosing and predicting...

    Authors: Yong Song, Hilda Higgins, Jing Guo, Katrina Harrison, En Nee Schultz, Belinda J. Hales, Eric K. Moses, Jack Goldblatt, Nicholas Pachter and Guicheng Zhang

    Citation: Journal of Translational Medicine 2018 16:42

    Published on:

  15. Content type: Research

    An extensive crosstalk co-regulates the Hippo and Wnt pathway. Preclinical studies revealed that the Hippo transducers YAP/TAZ mediate a number of oncogenic functions in gastric cancer (GC). Moreover, comprehe...

    Authors: Elisa Melucci, Beatrice Casini, Livia Ronchetti, Laura Pizzuti, Francesca Sperati, Matteo Pallocca, Francesca De Nicola, Frauke Goeman, Enzo Gallo, Carla Azzurra Amoreo, Domenico Sergi, Irene Terrenato, Patrizia Vici, Luigi Di Lauro, Maria Grazia Diodoro, Edoardo Pescarmona…

    Citation: Journal of Translational Medicine 2018 16:22

    Published on:

  16. Content type: Research

    Dental caries is a major worldwide oral disease afflicting a large proportion of children. As an important host factor of caries susceptibility, saliva plays a significant role in the occurrence and developmen...

    Authors: Kun Wang, Yufei Wang, Xiuqing Wang, Qian Ren, Sili Han, Longjiang Ding, Zhongcheng Li, Xuedong Zhou, Wei Li and Linglin Zhang

    Citation: Journal of Translational Medicine 2018 16:11

    Published on:

  17. Content type: Research

    Bladder cancer (BCa) is one of the most common cancers in the urinary system among the world. Previous studies suggested that TMEM40 expression level was significantly associated with clinicopathological param...

    Authors: Zhen-Fei Zhang, Han-Rong Zhang, Qing-Yan Zhang, Shu-Yu Lai, Yu-Zhen Feng, Yi Zhou, Si-Rong Zheng, Rong Shi and Jue-Yu Zhou

    Citation: Journal of Translational Medicine 2018 16:9

    Published on:

  18. Content type: Research

    To screen tumors with microsatellite instability (MSI) arising due to DNA mismatch repair deficiency (dMMR), a panel of five quasi-monomorphic mononucleotide-repeat markers amplified in a multiplex PCR (Pentap...

    Authors: Yuko Takehara, Takeshi Nagasaka, Akihiro Nyuya, Tomoko Haruma, Junko Haraga, Yoshiko Mori, Keiichiro Nakamura, Toshiyoshi Fujiwara, C. Richard Boland and Ajay Goel

    Citation: Journal of Translational Medicine 2018 16:5

    Published on:

  19. Content type: Research

    Plasma extracellular vesicles (EVs), especially exosome-like vesicles (ELVs), are being increasingly explored as a source of potential noninvasive disease biomarkers. The discovery of blood-based biomarkers as...

    Authors: Ruzena Stranska, Laurens Gysbrechts, Jens Wouters, Pieter Vermeersch, Katarzyna Bloch, Daan Dierickx, Graciela Andrei and Robert Snoeck

    Citation: Journal of Translational Medicine 2018 16:1

    Published on:

  20. Content type: Research

    In our previous study, we revealed that MEG3 was a tumor suppressor gene in retinoblastoma and inhibited proliferation of retinoblastoma cells by regulating the activity of the Wnt/β-catenin pathway. Here, we ...

    Authors: Yali Gao, Peng Huang and Jun Zhang

    Citation: Journal of Translational Medicine 2017 15:268

    Published on:

Page 1 of 11

2016 Journal Metrics

Advertisement