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Disease biomarkers

Section edited by Xiangdong Wang

This section aims to bridge the identification and validation of discovered gene or protein-based, network or dynamic network biomarkers with human diseases, patient phenotypes, or clinical applications, and accelerate the development of human disease-specific biomarkers for the early diagnosis, monitoring, evaluation, and prediction of diseases. Conditions including cancers, cardiovascular and metabolic diseases will be the focus of study. This section will promote the innovation and development of disease-specific biomarkers by integrating multidisciplinary aspects of science.

Studies considered for publication include those regarding the development of advanced biotechnologies for biomarker discovery and development, identifying biomarkers associated with the early detection of diseases, monitoring of disease severity and duration as well as patient responses to therapies, prediction of patient outcomes and the evaluation, regulation and ethics of disease biomarkers.

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  1. Nonalcoholic fatty liver disease (NAFLD) is the main cause for hepatocellular carcinoma (HCC). This study was intended to identify the function of long non-coding RNA (lncRNA) lncARSR in NAFLD and its role in ...

    Authors: Yuan Chi, Zheng Gong, He Xin, Ziwen Wang and Zhaoyu Liu

    Citation: Journal of Translational Medicine 2020 18:126

    Content type: Research

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  2. Rats with hyperandrogen-induced polycystic ovary syndrome (PCOS) have been shown to develop ovarian oxidative stress (OS) and fibrosis. The Sirt1 agonist, resveratrol, can reduce OS through inhibiting p66Shc i...

    Authors: Daojuan Wang, Tingyu Wang, Rong Wang, Xinlin Zhang, Lei Wang, Zou Xiang, Lingjia Zhuang, Shanmei Shen, Hongwei Wang, Qian Gao and Yong Wang

    Citation: Journal of Translational Medicine 2020 18:84

    Content type: Research

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  3. Clear cell renal cell carcinoma (ccRCC) is one of the most aggressive urological malignancies. MicroRNAs (miRNAs) are post-transcriptional gene regulators in tumor pathophysiology. As miRNAs exert cooperative ...

    Authors: Jiajia Chen, Yuqing Zhong and Liangzhi Li

    Citation: Journal of Translational Medicine 2020 18:69

    Content type: Research

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  4. Circulating tumor cells (CTCs) has been demonstrated as a promising liquid biopsy marker for breast cancer (BC). However, the intra-patient heterogeneity of CTCs remains a challenge to clinical application. We...

    Authors: Jing Chen, Changsheng Ye, Jianyu Dong, Shunwang Cao, Yanwei Hu, Bo Situ, Xiaoxue Xi, Sihua Qin, Jiasen Xu, Zhen Cai, Lei Zheng and Qian Wang

    Citation: Journal of Translational Medicine 2020 18:59

    Content type: Research

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  5. Predicting the clinical course of prostate cancer is challenging due to the wide biological spectrum of the disease. The objective of our study was to identify prostate cancer prognostic markers in patients ‘s...

    Authors: Michael A. Kiebish, Jennifer Cullen, Prachi Mishra, Amina Ali, Eric Milliman, Leonardo O. Rodrigues, Emily Y. Chen, Vladimir Tolstikov, Lixia Zhang, Kiki Panagopoulos, Punit Shah, Yongmei Chen, Gyorgy Petrovics, Inger L. Rosner, Isabell A. Sesterhenn, David G. McLeod…

    Citation: Journal of Translational Medicine 2020 18:10

    Content type: Research

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  6. The timely diagnosis of bacterial meningitis is of utmost importance due to the need to institute antibiotic treatment as early as possible. Moreover, the differentiation from other causes of meningitis/enceph...

    Authors: Leonardo Silva de Araujo, Kevin Pessler, Kurt-Wolfram Sühs, Natalia Novoselova, Frank Klawonn, Maike Kuhn, Volkhard Kaever, Kirsten Müller-Vahl, Corinna Trebst, Thomas Skripuletz, Martin Stangel and Frank Pessler

    Citation: Journal of Translational Medicine 2020 18:9

    Content type: Research

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  7. Serum protein glycosylation is an area of investigation in inflammatory arthritic disorders such as rheumatoid arthritis (RA). Indeed, some studies highlighted abnormalities of protein glycosylation in RA. Con...

    Authors: Federica Ciregia, Dominique Baiwir, Gaël Cobraiville, Thibaut Dewael, Gabriel Mazzucchelli, Valérie Badot, Silvana Di Romana, Paschalis Sidiras, Tatiana Sokolova, Patrick Durez, Michel G. Malaise and Dominique de Seny

    Citation: Journal of Translational Medicine 2020 18:8

    Content type: Research

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  8. The prevalence of autoimmune hepatitis (AIH) is increasing, and its early clinical diagnosis is difficult. The pathogenesis of AIH remains unclear, and AIH-related studies are largely limited because of lack o...

    Authors: Han Wang, Wei Yan, Zuohua Feng, Yuan Gao, Liu Zhang, Xinxia Feng and Dean Tian

    Citation: Journal of Translational Medicine 2020 18:3

    Content type: Research

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  9. Lung cancer is the leading cause of cancer-related death worldwide, and the timely and serial assessment of low-dose computed tomography (LDCT) in high-risk populations remains a challenge. Furthermore, testin...

    Authors: Ruochuan Zang, Xinfeng Wang, Runsen Jin, Yuanyuan Lei, Jianbing Huang, Chengming Liu, Sufei Zheng, Fang Zhou, Qian Wu, Nan Sun, Shugeng Gao and Jie He

    Citation: Journal of Translational Medicine 2019 17:430

    Content type: Research

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  10. Telocytes (TCs) are newly identified interstitial cells that participate in tissue protection and repair. The present study investigated the mechanisms underlying the protective effect of TCs in a mouse model ...

    Authors: Yile Zhou, Yajie Yang, Tao Liang, Yan Hu, Haihong Tang, Dongli Song and Hao Fang

    Citation: Journal of Translational Medicine 2019 17:427

    Content type: Research

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  11. Chemokines are small chemotactic cytokines involved in inflammation, cell migration, and immune regulation in both physiological and pathological contexts. Here, we investigated the profile of chemokines durin...

    Authors: Xiaowan Yin, Zhuo Wang, Tong Wu, Meichen Ma, Zining Zhang, Zhenxing Chu, Qinghai Hu, Haibo Ding, Xiaoxu Han, Junjie Xu, Hong Shang and Yongjun Jiang

    Citation: Journal of Translational Medicine 2019 17:417

    Content type: Research

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  12. Mid-regional pro atrial natriuretic peptide (MR-proANP) is an established biomarker for heart failure, based on its key role in regulating homeostasis of water balance and blood pressure. The aim of the study ...

    Authors: Eray Yagmur, Johanna Hermine Sckaer, Ger H. Koek, Ralf Weiskirchen, Christian Trautwein, Alexander Koch and Frank Tacke

    Citation: Journal of Translational Medicine 2019 17:415

    Content type: Research

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  13. Treatment stratification based on bone marrow minimal residual disease (MRD) at set time points has resulted in considerably improved survival in pediatric acute lymphoblastic leukemia (ALL). Treatment respons...

    Authors: Andrea Rzepiel, Nóra Kutszegi, András Gézsi, Judit C. Sági, Bálint Egyed, György Péter, Henriett Butz, Gábor Nyírő, Judit Müller, Gábor T. Kovács, Csaba Szalai, Ágnes F. Semsei and Dániel J. Erdélyi

    Citation: Journal of Translational Medicine 2019 17:372

    Content type: Research

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  14. There continues to be a great need for better biomarkers and host-directed treatment targets for community-acquired pneumonia (CAP). Alterations in phospholipid metabolism may constitute a source of small mole...

    Authors: Haroon Arshad, Juan Carlos López Alfonso, Raimo Franke, Katina Michaelis, Leonardo Araujo, Aamna Habib, Yuliya Zboromyrska, Eva Lücke, Emilia Strungaru, Manas K. Akmatov, Haralampos Hatzikirou, Michael Meyer-Hermann, Astrid Petersmann, Matthias Nauck, Mark Brönstrup, Ursula Bilitewski…

    Citation: Journal of Translational Medicine 2019 17:365

    Content type: Research

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  15. Growing evidence has demonstrated immune reactivity as a confirmed important carcinogenesis and therapy efficacy for clear cell renal cell carcinoma (ccRCC). Aquaporin 9 (AQP9) is involved in many immune-relat...

    Authors: Wen-Hao Xu, Shen-Nan Shi, Yue Xu, Jun Wang, Hong-Kai Wang, Da-Long Cao, Guo-Hai Shi, Yuan-Yuan Qu, Hai-Liang Zhang and Ding-Wei Ye

    Citation: Journal of Translational Medicine 2019 17:363

    Content type: Research

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  16. Emerging evidence shows that microRNA-130 (miRNA-130) family may be useful as prognostic biomarkers in cancer. However, there is no confirmation in an independent validation study. The aim of this study was to...

    Authors: Zhen Peng, Fujiao Duan, Jingjing Yin, Yajing Feng, Zhongyu Yang and Jia Shang

    Citation: Journal of Translational Medicine 2019 17:347

    Content type: Research

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  17. Noninvasive prognostic biomarkers are needed for advanced non-small cell lung cancer (NSCLC) patients with different histological types to identify cases with poor survival. Here, we investigated the prognosti...

    Authors: Chao Liu, Wang Jing, Ning An, Aijie Li, Weiwei Yan, Hui Zhu and Jinming Yu

    Citation: Journal of Translational Medicine 2019 17:344

    Content type: Research

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  18. MicroRNAs (miRNAs) are promising biomarkers due to their structural stability and distinct expression profile in various cancers. We wanted to explore the miRNA expression in benign breast tissue and breast ca...

    Authors: Line Moi, Tonje Braaten, Khalid Al-Shibli, Eiliv Lund and Lill-Tove Rasmussen Busund

    Citation: Journal of Translational Medicine 2019 17:334

    Content type: Research

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  19. Brain metastases (BM) are the most common intracranial tumors. 2–14% of BM patients present with unknown primary site despite intensive evaluations. This study aims to evaluate the performance of a 90-gene exp...

    Authors: Yulong Zheng, Yongfeng Ding, Qifeng Wang, Yifeng Sun, Xiaodong Teng, Qiqi Gao, Weixiang Zhong, Xiaofeng Lou, Cheng Xiao, Chengshu Chen, Qinghua Xu and Nong Xu

    Citation: Journal of Translational Medicine 2019 17:331

    Content type: Research

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  20. DNA methylation can regulate the role of long noncoding RNAs (lncRNAs) in the development of lung adenocarcinoma (LUAD). The present study aimed to identify methylation-driven lncRNAs and mRNAs as biomarkers i...

    Authors: Rui Li, Yi-E Yang, Yun-Hong Yin, Meng-Yu Zhang, Hao Li and Yi-Qing Qu

    Citation: Journal of Translational Medicine 2019 17:324

    Content type: Research

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  21. Advances in microRNAs (miRNAs) biomarkers have generated disease markers with potential clinical values. However, none of these published results have been applied in clinic until today. The main reason could ...

    Authors: Yanqin Niu, Sijian Xia, Mingyang Su, Quanjin Dang, Kang Kang, Li Li and Deming Gou

    Citation: Journal of Translational Medicine 2019 17:316

    Content type: Research

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  22. Conventional clinical biomarkers cannot accurately differentiate indolent from aggressive prostate cancer (PCa). We investigated the usefulness of a biomarker panel measured exclusively in biofluids for assess...

    Authors: Xavier Ruiz-Plazas, Esther Rodríguez-Gallego, Marta Alves, Antonio Altuna-Coy, Javier Lozano-Bartolomé, Manel Portero-Otin, Joan Francesc García-Fontgivell, Salomé Martínez-González, José Segarra and Matilde R. Chacón

    Citation: Journal of Translational Medicine 2019 17:307

    Content type: Research

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  23. Annexins are involved in vesicle trafficking, cell proliferation and apoptosis, but their functional mechanisms in ovarian cancer remain unclear. In this study, we analyzed Annexins in ovarian cancer using dif...

    Authors: Rui Gou, Liancheng Zhu, Mingjun Zheng, Qian Guo, Yuexin Hu, Xiao Li, Juanjuan Liu and Bei Lin

    Citation: Journal of Translational Medicine 2019 17:275

    Content type: Research

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  24. Numerous evidence has suggested that long non-coding RNA (lncRNA) acts an important role in tumor biology. This study focuses on the identification of novel prognostic lncRNA biomarkers predicting tumor recurr...

    Authors: Fangyao Chen, Zhe Li, Changyu Deng and Hong Yan

    Citation: Journal of Translational Medicine 2019 17:299

    Content type: Research

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  25. Perrault syndrome is a rare autosomal recessive disorder that is characterized by the association of sensorineural hearing impairment and ovarian dysgenesis in females, whereas males have only hearing impairme...

    Authors: María Domínguez-Ruiz, Alberto García-Martínez, Marc Corral-Juan, Ángel I. Pérez-Álvarez, Ana M. Plasencia, Manuela Villamar, Miguel A. Moreno-Pelayo, Antoni Matilla-Dueñas, Manuel Menéndez-González and Ignacio del Castillo

    Citation: Journal of Translational Medicine 2019 17:290

    Content type: Research

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  26. Hepatocellular carcinoma is the second most deadly cancer with late presentation and limited treatment options, highlighting an urgent need to better understand HCC to facilitate the identification of early-st...

    Authors: Yu Jin, Wai Yeow Lee, Soo Ting Toh, Chandana Tennakoon, Han Chong Toh, Pierce Kah-Hoe Chow, Alexander Y.-F. Chung, Samuel S. Chong, London L.-P.-J. Ooi, Wing-Kin Sung and Caroline G.-L. Lee

    Citation: Journal of Translational Medicine 2019 17:273

    Content type: Research

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  27. Primary Sjögren’s syndrome (pSS) is an autoimmune disorder mainly characterized by exocrine gland injury. Costimulatory molecules play an important role in immune-regulatory networks. Although B7 family costim...

    Authors: Ping Li, Ying Yang, Yi Jin, Rui Zhao, Chen Dong, Wenjie Zheng, Tianyi Zhang, Jing Li and Zhifeng Gu

    Citation: Journal of Translational Medicine 2019 17:268

    Content type: Research

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  28. Noninvasive and effective methods of early diagnosis of colorectal cancer (CRC) are underexplored. Inflammation is known to play an important role in the tumor microenvironment of CRC. Therefore, the aim of th...

    Authors: Dan Wang, Weitang Yuan, Yaping Wang, Qian Wu, Li Yang, Feng Li, Xinfeng Chen, Zhen Zhang, Weina Yu, Nomathamsanqa Resegofetse Maimela, Ling Cao, Dong Wang, Junxia Wang, Zhenqiang Sun, Jinbo Liu and Yi Zhang

    Citation: Journal of Translational Medicine 2019 17:253

    Content type: Research

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  29. Mitochondrial DNA (mtDNA) haplogroups have been associated with advanced liver fibrosis and cirrhosis in patients coinfected with human immunodeficiency virus (HIV) and hepatitis C virus (HCV). Our aim was to ...

    Authors: Teresa Aldámiz-Echevarría, Salvador Resino, José M. Bellón, María A. Jiménez-Sousa, Pilar Miralles, Luz M. Medrano, Ana Carrero, Cristina Díez, Leire Pérez-Latorre, Chiara Fanciulli, Pilar Garcia-Broncano and Juan Berenguer

    Citation: Journal of Translational Medicine 2019 17:244

    Content type: Research

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  30. Indoleamine 2,3-dioxygenase catalyzes the conversion of tryptophan to kynurenine, an immunosuppressive metabolite involved in T regulatory cell differentiation. Indoleamine 2,3-dioxygenase is expressed in many...

    Authors: Concetta Elisa Onesti, François Boemer, Claire Josse, Stephane Leduc, Vincent Bours and Guy Jerusalem

    Citation: Journal of Translational Medicine 2019 17:239

    Content type: Research

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  31. Chronic kidney disease (CKD) is a universal chronic disease in China. The balance of the gut microbiome is highly crucial for a healthy human body, especially for the immune system. However, the relationship b...

    Authors: Yang Li, Xinhuan Su, Lei Zhang, Yanwei Liu, Min Shi, Chenxiao Lv, Ying Gao, Dongmei Xu and Zunsong Wang

    Citation: Journal of Translational Medicine 2019 17:228

    Content type: Research

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  32. Lynch syndrome (LS) is a highly penetrant inherited cancer predisposition syndrome, characterized by autosomal dominant inheritance and germline mutations in DNA mismatch repair genes. Despite several genetic ...

    Authors: Amira Jaballah-Gabteni, Haifa Tounsi, Maria Kabbage, Yosr Hamdi, Sahar Elouej, Ines Ben Ayed, Mouna Medhioub, Moufida Mahmoudi, Hamza Dallali, Hamza Yaiche, Nadia Ben Jemii, Afifa Maaloul, Najla Mezghani, Sonia Abdelhak, Lamine Hamzaoui, Mousaddak Azzouz…

    Citation: Journal of Translational Medicine 2019 17:212

    Content type: Research

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  33. Glioma is the most common primary malignant brain tumor in adults with a poor prognosis. ARL3 is a member of the ARF family, and plays a key role in ciliary function and lipid-modified protein trafficking. ARL...

    Authors: Yulin Wang, Weijiang Zhao, Xin Liu, Gefei Guan and Minghua Zhuang

    Citation: Journal of Translational Medicine 2019 17:210

    Content type: Research

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  34. Colorectal cancer (CRC) is the third leading cause of cancer-related mortality worldwide. Current systematic methods for diagnosing have inherent limitations so development of a minimally-invasive diagnosis, b...

    Authors: Berta Roman-Canal, Jordi Tarragona, Cristian Pablo Moiola, Sònia Gatius, Sarah Bonnin, Maria Ruiz-Miró, José Enrique Sierra, Maria Rufas, Esperanza González, José M. Porcel, Antonio Gil-Moreno, Juan M. Falcón-Pérez, Julia Ponomarenko, Xavier Matias-Guiu and Eva Colas

    Citation: Journal of Translational Medicine 2019 17:208

    Content type: Research

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  35. Due to the phenotypic and molecular diversity of hepatocellular carcinomas (HCC), it is still a challenge to determine patients’ prognosis. We aim to identify new prognostic markers for resected HCC patients.

    Authors: Gui-Qi Zhu, Yi Yang, Er-Bao Chen, Biao Wang, Kun Xiao, Shi-Ming Shi, Zheng-Jun Zhou, Shao-Lai Zhou, Zheng Wang, Ying-Hong Shi, Jia Fan, Jian Zhou, Tian-Shu Liu and Zhi Dai

    Citation: Journal of Translational Medicine 2019 17:203

    Content type: Research

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  36. Platelets not only contribute to hemostasis but also to the regulation of inflammatory reactions and cancer pathogenesis. We hypothesized that blood platelet count would be associated with systemic inflammatio...

    Authors: Juha P. Väyrynen, Sara A. Väyrynen, Päivi Sirniö, Ilkka Minkkinen, Kai Klintrup, Toni Karhu, Jyrki Mäkelä, Karl-Heinz Herzig, Tuomo J. Karttunen, Anne Tuomisto and Markus J. Mäkinen

    Citation: Journal of Translational Medicine 2019 17:199

    Content type: Research

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  37. Early diagnosis is critical to reduce the mortality caused by nasopharyngeal carcinoma (NPC). MicroRNAs (miRNAs) are dysregulated and play important roles in carcinogenesis. Therefore, this study aimed to iden...

    Authors: Wen Wen, Shi-Juan Mai, Huan-Xin Lin, Mei-Yin Zhang, Jia-Ling Huang, Xin Hua, Chao Lin, Zhi-Qing Long, Zi-Jian Lu, Xiao-Qing Sun, Sai-Lan Liu, Qi Yang, Qian Zhu, Hui-Yun Wang and Ling Guo

    Citation: Journal of Translational Medicine 2019 17:186

    Content type: Research

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  38. SWATH-MS has emerged as the strategy of choice for biomarker discovery due to the proteome coverage achieved in acquisition and provision to re-interrogate the data. However, in quantitative analysis using SWA...

    Authors: Mythreyi Narasimhan, Sadhana Kannan, Aakash Chawade, Atanu Bhattacharjee and Rukmini Govekar

    Citation: Journal of Translational Medicine 2019 17:184

    Content type: Research

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  39. Prostate cancer is an extremely heterogeneous disease. Despite being clinically similar, some tumours are more likely to recur after surgery compared to others. Distinguishing those that need adjuvant or salva...

    Authors: C. Hoey, M. Ahmed, A. Fotouhi Ghiam, D. Vesprini, X. Huang, K. Commisso, A. Commisso, J. Ray, E. Fokas, D. A. Loblaw, H. H. He and S. K. Liu

    Citation: Journal of Translational Medicine 2019 17:173

    Content type: Research

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  40. Amyotrophic lateral sclerosis (ALS) is a debilitating disease with few treatment options. Progress towards new therapies requires validated disease biomarkers, but there is no consensus on which fluid-based me...

    Authors: William R. Swindell, Colin P. S. Kruse, Edward O. List, Darlene E. Berryman and John J. Kopchick

    Citation: Journal of Translational Medicine 2019 17:170

    Content type: Research

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  41. Acute myeloid leukemia (AML) is a heterogeneous disease in terms of genetic basis, clinical, biological and prognostic, and is a malignant clonal disease of leukemia stem cells (LSCs). Nearly half of adult AML...

    Authors: Ying Song, Weilong Zhang, Xue He, Xiaoni Liu, Ping Yang, Jing Wang, Kai Hu, Weiyou Liu, Xiuru Zhang, Hongmei Jing and Xiaoliang Yuan

    Citation: Journal of Translational Medicine 2019 17:166

    Content type: Research

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  42. Translational medicine (TM) is an emerging domain that aims to facilitate medical or biological advances efficiently from the scientist to the clinician. Central to the TM vision is to narrow the gap between b...

    Authors: Laura Bravo-Merodio, John A. Williams, Georgios V. Gkoutos and Animesh Acharjee

    Citation: Journal of Translational Medicine 2019 17:155

    Content type: Research

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  43. The high mortality of patients with non-small cell lung cancer (NSCLC) emphasizes the necessity of identifying a robust and reliable prognostic signature for NSCLC patients. This study aimed to identify and va...

    Authors: Shuguang Zuo, Min Wei, Hailin Zhang, Anxian Chen, Junhua Wu, Jiwu Wei and Jie Dong

    Citation: Journal of Translational Medicine 2019 17:152

    Content type: Research

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  44. The available prognostic scoring systems for severe acute pancreatitis (SAP) have limitations that restrict their clinical value. The aim of this study was to develop a simple model (score) that could rapidly ...

    Authors: Wandong Hong, Keith D. Lillemoe, Shuang Pan, Vincent Zimmer, Evangelos Kontopantelis, Simon Stock, Maddalena Zippi, Chao Wang and Mengtao Zhou

    Citation: Journal of Translational Medicine 2019 17:146

    Content type: Research

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  45. The distant metastasis of cancer cells is a risk factor for tumor lethality and poor prognosis in non-small-cell lung carcinoma (NSCLC). Increased SOX9 expression has been associated with clinical stage and po...

    Authors: Jing-Qiang Huang, Fa-Kai Wei, Xiu-Li Xu, Shi-Xing Ye, Jun-Wei Song, Pei-Kun Ding, Jing Zhu, He-Feng Li, Xin-Ping Luo, Hui Gong, Li Su, Lin Yang and Li-Yun Gong

    Citation: Journal of Translational Medicine 2019 17:143

    Content type: Research

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  46. Serum GP73 is a useful biomarker in assessing hepatic fibrosis degree. The aim of this study was to evaluate the predictive value of serum GP73 level for posthepatectomy short-term outcomes in hepatocellular c...

    Authors: Meng-yun Ke, Xiao-ning Wu, Yao Zhang, Saisai Wang, Yi Lv and Jian Dong

    Citation: Journal of Translational Medicine 2019 17:140

    Content type: Research

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  47. Acute kidney injury (AKI) is a common complication of acute myocardial infarction (AMI), and is associated with adverse outcomes. The study aimed to identify a miRNA signature for the early diagnosis of post-A...

    Authors: Pei-Chun Fan, Chia-Chun Chen, Chen-Ching Peng, Chih-Hsiang Chang, Chia-Hung Yang, Chi Yang, Lichieh Julie Chu, Yung-Chang Chen, Chih-Wei Yang, Yu-Sun Chang and Pao-Hsien Chu

    Citation: Journal of Translational Medicine 2019 17:139

    Content type: Research

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  48. While prostate cancer can often manifest as an indolent disease, the development of locally-advanced or metastatic disease can cause significant morbidity or mortality. Elucidation of molecular mechanisms cont...

    Authors: Aruz Mesci, Fabrice Lucien, Xiaoyong Huang, Eric H. Wang, David Shin, Michelle Meringer, Christianne Hoey, Jessica Ray, Paul C. Boutros, Hon S. Leong and Stanley K. Liu

    Citation: Journal of Translational Medicine 2019 17:125

    Content type: Research

    Published on:

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