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Personalized medicine

Section edited by Lotfi Chouchane

This section aims to provide a platform for research that will revolutionize patient care through the use of novel molecular predisposing screening, diagnostic, prognostic and pharmacogenomics. Advances in human genome research are opening the door to a new paradigm for practicing medicine that promises to transform healthcare. Personalized medicine will impact the way that medicine is practiced.

Featured articles

Pharmacogenetics driving personalized medicine: analysis of genetic polymorphisms related to breast cancer medications in Italian isolated populations
Massimiliano Cocca, et al

Anti-cytokine autoantibodies in postherpetic neuralgia
Ahmad Bayat, et al



Comprehensive molecular characterization of human adipocytes reveals a transient brown phenotype
Andrea Guennoun, et al

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  1. Type 1 diabetes affects millions of people globally and requires careful management to avoid serious long-term complications, including heart and kidney disease, stroke, and loss of sight. The type 1 diabetes ...

    Authors: Ammira Al-Shabeeb Akil, Esraa Yassin, Aljazi Al-Maraghi, Elbay Aliyev, Khulod Al-Malki and Khalid A. Fakhro

    Citation: Journal of Translational Medicine 2021 19:137

    Content type: Review

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  2. The incidence of breast cancer (BC) and/or ovarian cancer (OC) is increasing in Tunisia especially in young women and mostly those with family history. However, the spectrum of BRCA mutations remains little explo...

    Authors: Dorra Ben Ayed-Guerfali, Wala Ben Kridis-Rejab, Nihel Ammous-Boukhris, Wajdi Ayadi, Slim Charfi, Afef Khanfir, Tahia Sellami-Boudawara, Mounir Frikha, Jamel Daoud and Raja Mokdad-Gargouri

    Citation: Journal of Translational Medicine 2021 19:108

    Content type: Research

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  3. Hypertension (HTN), diabetes mellitus (DM), and dyslipidemia (DL) are well-known risk factors of cardiovascular disease (CVD), but not all patients develop CVDs. Studies have been limited investigating genetic...

    Authors: Youhyun Song, Ja-Eun Choi, Yu-Jin Kwon, Hyuk-Jae Chang, Jung Oh Kim, Da-Hyun Park, Jae-Min Park, Seong-Jin Kim, Ji Won Lee and Kyung-Won Hong

    Citation: Journal of Translational Medicine 2021 19:85

    Content type: Research

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  4. Melanoma is the deadliest of skin cancers and has an increasing annual incidence worldwide. It is a multi-factorial disease most likely arising from both genetic predisposition and environmental exposure to ul...

    Authors: Clara Benna, Senthilkumar Rajendran, Giovanna Spiro, Chiara Menin, Luigi Dall’Olmo, Carlo Riccardo Rossi and Simone Mocellin

    Citation: Journal of Translational Medicine 2021 19:57

    Content type: Research

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  5. Genome-wide association studies have identified thousands of disease-associated single nucleotide polymorphisms (SNPs). A subset of these SNPs may be additively combined to generate genetic risk scores (GRSs) ...

    Authors: Carly A. Conran, Zhuqing Shi, William Kyle Resurreccion, Rong Na, Brian T. Helfand, Elena Genova, Siqun Lilly Zheng, Charles B. Brendler and Jianfeng Xu

    Citation: Journal of Translational Medicine 2021 19:41

    Content type: Research

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  6. Aberrant metabolism is the root cause of several serious health issues, creating a huge burden to health and leading to diminished life expectancy. A dysregulated metabolism induces the secretion of several mo...

    Authors: Murugan Subramanian, Anne Wojtusciszyn, Lucie Favre, Sabri Boughorbel, Jingxuan Shan, Khaled B. Letaief, Nelly Pitteloud and Lotfi Chouchane

    Citation: Journal of Translational Medicine 2020 18:472

    Content type: Review

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  7. The outbreak of coronavirus disease (COVID-19) was caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), through its surface spike glycoprotein (S-protein) recognition on the receptor Angiote...

    Authors: Xingyi Guo, Zhishan Chen, Yumin Xia, Weiqiang Lin and Hongzhi Li

    Citation: Journal of Translational Medicine 2020 18:321

    Content type: Research

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  8. Conotruncal defects (CTDs) are a type of heterogeneous congenital heart diseases (CHDs), but little is known about their etiology. Increasing evidence has demonstrated that fibroblast growth factor (FGF) 8 and...

    Authors: Shuang Zhou, Qingjie Wang, Zhuo Meng, Jiayu Peng, Yue Zhou, Wenting Song, Jian Wang, Sun Chen and Kun Sun

    Citation: Journal of Translational Medicine 2020 18:283

    Content type: Research

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  9. In the context of our Regional Program of Hereditary Cancer, individuals fulfilling the criteria are tested for germline mutations to subsequently establish the clinical management. Our standard diagnostic app...

    Authors: Carolina Velázquez, Enrique Lastra, Francisco Avila Cobos, Luis Abella, Virginia de la Cruz, Blanca Ascensión Hernando, Lara Hernández, Noemí Martínez, Mar Infante and Mercedes Durán

    Citation: Journal of Translational Medicine 2020 18:232

    Content type: Research

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  10. Radiation-induced oral mucositis (OM) is one of the most common acute complications for head and neck cancer. Severe OM is associated with radiation treatment breaks, which harms successful tumor management. R...

    Authors: Da-Wei Yang, Tong-Min Wang, Jiang-Bo Zhang, Xi-Zhao Li, Yong-Qiao He, Ruowen Xiao, Wen-Qiong Xue, Xiao-Hui Zheng, Pei-Fen Zhang, Shao-Dan Zhang, Ye-Zhu Hu, Guo-Ping Shen, Mingyuan Chen, Ying Sun and Wei-Hua Jia

    Citation: Journal of Translational Medicine 2020 18:224

    Content type: Research

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  11. Malignant serous effusion (MSE) denotes a manifestation of metastatic disease with typical high concentrations of both cancer and immune cells, making them an ideal resource for in vitro cytologic studies. Hen...

    Authors: Cheng-Guang Wu, Francesca Chiovaro, Alessandra Curioni-Fontecedro, Ruben Casanova and Alex Soltermann

    Citation: Journal of Translational Medicine 2020 18:163

    Content type: Research

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  12. Immune checkpoint inhibitors are effective in some cases of lung adenocarcinoma (LUAD). Whole-exome sequencing has revealed that the tumour mutation burden (TMB) is associated with clinical benefits among pati...

    Authors: Ying Li, Wenbin Jiang, Tianhao Li, Mengyue Li, Xin Li, Zheyang Zhang, Sainan Zhang, Yixin Liu, Wenyuan Zhao, Yunyan Gu, Lishuang Qi, Lu Ao and Zheng Guo

    Citation: Journal of Translational Medicine 2020 18:25

    Content type: Research

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  13. The 18-gene tumor inflammation signature (TIS) is a clinical research assay that enriches for clinical benefit to immune checkpoint blockade. We evaluated its ability to predict clinical benefit of immunothera...

    Authors: Diane Damotte, Sarah Warren, Jennifer Arrondeau, Pascaline Boudou-Rouquette, Audrey Mansuet-Lupo, Jérôme Biton, Hanane Ouakrim, Marco Alifano, Claire Gervais, Audrey Bellesoeur, Nora Kramkimel, Camille Tlemsani, Barbara Burroni, Angéline Duche, Franck Letourneur, Han Si…

    Citation: Journal of Translational Medicine 2019 17:357

    Content type: Research

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  14. Obesity is associated with an increased risk of insulin resistance and type 2 diabetes mellitus (T2DM). However, some obese individuals maintain their insulin sensitivity and exhibit a lower risk of associated...

    Authors: Haya Al-Sulaiti, Ilhame Diboun, Maha V. Agha, Fatima F. S. Mohamed, Stephen Atkin, Alex S. Dömling, Mohamed A. Elrayess and Nayef A. Mazloum

    Citation: Journal of Translational Medicine 2019 17:348

    Content type: Research

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  15. Liquid biopsy based on cell-free DNA circulating in plasma has shown solid results as a non-invasive biomarker. In the present study we evaluated the utility of circulating free DNA (cfDNA) and the sub-type tu...

    Authors: Marianna Alunni-Fabbroni, Kerstin Rönsch, Thomas Huber, Clemens C. Cyran, Max Seidensticker, Julia Mayerle, Maciej Pech, Bristi Basu, Chris Verslype, Julia Benckert, Peter Malfertheiner and Jens Ricke

    Citation: Journal of Translational Medicine 2019 17:328

    Content type: Research

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  16. Minimal hepatic encephalopathy (MHE) in cirrhotic patients is associated with specific changes in parameters of the immune system reflecting a more pro-inflammatory environment than in patients without MHE. Th...

    Authors: Alba Mangas-Losada, Raquel García-García, Paola Leone, María Pilar Ballester, Andrea Cabrera-Pastor, Amparo Urios, Juan-José Gallego, Juan-José Martínez-Pretel, Carla Giménez-Garzó, Fernando Revert, Desamparados Escudero-García, Joan Tosca, María Pilar Ríos, Cristina Montón, Lucia Durbán, Luis Aparicio…

    Citation: Journal of Translational Medicine 2019 17:293

    Content type: Research

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  17. Pituitary adenomas are common brain tumors. Although transsphenoidal surgery are able to achieve extensive tumor removal, the rate of recurrence ranges from 5 to 20% depending on the different subtype. Further...

    Authors: Jie Feng, Hua Gao, Qi Zhang, Yang Zhou, Chuzhong Li, Sida Zhao, Lichuan Hong, Jinjin Yang, Shuyu Hao, Wan Hong, Zhengping Zhuang, Guowang Xu and Yazhuo Zhang

    Citation: Journal of Translational Medicine 2019 17:291

    Content type: Research

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  18. Currently, in vivo model for personalised cancer drug testing is challenging. A zebrafish larvae xenograft model has been applied in recent years to cancer research, particularly for drug testing purposes, sho...

    Authors: Ahmed Al-Samadi, Katja Tuomainen, Anne Kivimäki, Abdelhakim Salem, Sakhr Al-Kubati, Aini Hyytiäinen, Mataleena Parikka, Karri Mesimäki, Tommy Wilkman, Antti Mäkitie, Reidar Grenman and Tuula Salo

    Citation: Journal of Translational Medicine 2019 17:235

    Content type: Research

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  19. Diabetes is a chronic disease associated with many problems and high costs. In recent decades, a lot of research has been carried out in order to improve methods of treatment of diabetic patients. One of the c...

    Authors: Fouad Mehraban, Arefeh Seyedarabi, Shahin Ahmadian, Vahid Mirzaaghaei and Ali Akbar Moosavi-Movahedi

    Citation: Journal of Translational Medicine 2019 17:227

    Content type: Research

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  20. The influence of DNMT3A R882 mutations on adult acute myeloid leukemia (AML) prognosis is still controversial presently. The influence of R882 allele ratio on drug response and prognosis of AML is unknown yet. Be...

    Authors: Xiao-Qing Yuan, Peng Chen, Yin-Xiao Du, Ke-Wei Zhu, Dao-Yu Zhang, Han Yan, Han Liu, Yan-Ling Liu, Shan Cao, Gan Zhou, Hui Zeng, Shu-Ping Chen, Xie-Lan Zhao, Jing Yang, Wen-Jing Zeng and Xiao-Ping Chen

    Citation: Journal of Translational Medicine 2019 17:220

    Content type: Research

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  21. Rupture of an intracranial aneurysm (IA) causes a systemic response that involves an immune/inflammatory reaction. Our previous study revealed a downregulation of genes related to T lymphocytes and an upregula...

    Authors: Michal Korostynski, Marcin Piechota, Rafal Morga, Dzesika Hoinkis, Slawomir Golda, Magdalena Zygmunt, Tomasz Dziedzic, Marek Moskala, Agnieszka Slowik and Joanna Pera

    Citation: Journal of Translational Medicine 2019 17:141

    Content type: Research

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  22. Over the past few years, next-generation sequencing (NGS) has become reliable and cost-effective, and its use in clinical practice has become a reality. A relevant role for NGS is the prediction of response to...

    Authors: Edoardo Isnaldi, Anna Garuti, Gabriella Cirmena, Stefano Scabini, Edoardo Rimini, Lorenzo Ferrando, Michela Lia, Roberto Murialdo, Lucia Tixi, Enrico Carminati, Andrea Panaro, Maurizio Gallo, Federica Grillo, Luca Mastracci, Lazzaro Repetto, Roberto Fiocca…

    Citation: Journal of Translational Medicine 2019 17:137

    Content type: Research

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  23. The dynein axonemal heavy chain (DNAH) family of genes encode the dynein axonemal heavy chain, which is involved in cell motility. Genomic variations of DNAH family members have been frequently reported in div...

    Authors: Chunchao Zhu, Qin Yang, Jia Xu, Wenyi Zhao, Zizhen Zhang, Danhua Xu, Yeqian Zhang, Enhao Zhao and Gang Zhao

    Citation: Journal of Translational Medicine 2019 17:109

    Content type: Research

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  24. SETD2, the single mediator of trimethylation of histone 3 at position lysine 36, has been reported associated with initiation progression and chemotherapy resistance in acute myeloid leukemia (AML). Whether polym...

    Authors: Suwei Wang, Xiaoqing Yuan, Yazhen Liu, Kewei Zhu, Peng Chen, Han Yan, Daoyu Zhang, Xi Li, Hui Zeng, Xielan Zhao, Xiaoping Chen, Gan Zhou and Shan Cao

    Citation: Journal of Translational Medicine 2019 17:101

    Content type: Research

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  26. MET amplification is associated with acquired resistance to first-generation epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitors (TKIs) in treating non-small-cell lung cancer (NSCLC); however, t...

    Authors: Wenxian Wang, Hong Wang, Peihua Lu, Zongyang Yu, Chunwei Xu, Wu Zhuang and Zhengbo Song

    Citation: Journal of Translational Medicine 2019 17:52

    Content type: Research

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  27. Patients with Idiopathic membranous nephropathy (IMN) have various outcomes. The aim of this study is to construct a tool for clinicians to precisely predict outcome of IMN.

    Authors: Hu Xiaofan, Xu Jing, Gao Chenni, Wu Yifan, Yu Xialian, Lin Li, Ren Hong, Zhang Wen, Wang Weiming, Pan Xiaoxia, Xie Jingyuan and Chen Nan

    Citation: Journal of Translational Medicine 2019 17:41

    Content type: Research

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  28. Among breast cancer (BC) patients, near 40% are post-menopause, and 70%–80% are hormone receptor (HR)-positive. About 30%–40% BC patients who are diagnosed as invasive carcinoma HR-positive BC would eventually...

    Authors: Jingyu Liu, Jing Li, Hui Wang, Yikai Wang, Qiongzhi He, Xuefeng Xia, Zhe-Yu Hu and Quchang Ouyang

    Citation: Journal of Translational Medicine 2019 17:27

    Content type: Research

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  29. Renal transplantation is increasingly associated with the presence of comorbidity factors such as dyslipidemia which could influence the graft outcome. We hypothesized that hypercholesterolemia could affect va...

    Authors: Thomas Kerforne, Frédéric Favreau, Tackwa Khalifeh, Souleymane Maiga, Geraldine Allain, Antoine Thierry, Manuel Dierick, Edouard Baulier, Clara Steichen and Thierry Hauet

    Citation: Journal of Translational Medicine 2019 17:26

    Content type: Research

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  30. In order to establish the workflows required to implement a real-time process involving multi-omic analysis of patient samples to support precision-guided therapeutic intervention, a tissue acquisition and ana...

    Authors: Zahi I. Mitri, Swapnil Parmar, Brett Johnson, Annette Kolodzie, Jamie M. Keck, Max Morris, Alexander R. Guimaraes, Brooke R. Beckett, Uma Borate, Charles D. Lopez, Kathleen A. Kemmer, Joshi J. Alumkal, Tomasz M. Beer, Christopher L. Corless, Gordon B. Mills, Joe W. Gray…

    Citation: Journal of Translational Medicine 2018 16:358

    Content type: Research

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  31. Current guidelines recommend angiotensin-converting-enzyme inhibitors (ACEI) or angiotensin-receptor blockers (ARB) or β-blockers (β-B) for secondary prevention in patients after an acute myocardial infarction...

    Authors: Xuhe Gong, Xiaosong Ding, Hui Chen and Hongwei Li

    Citation: Journal of Translational Medicine 2018 16:346

    Content type: Research

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  32. Dysfunction of the circadian clock and polymorphisms of some circadian genes have been linked to cancer development and progression. We investigated the relationship between circadian genes germline variation ...

    Authors: Clara Benna, Senthilkumar Rajendran, Giovanna Spiro, Saveria Tropea, Paolo Del Fiore, Carlo Riccardo Rossi and Simone Mocellin

    Citation: Journal of Translational Medicine 2018 16:338

    Content type: Research

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  33. The International Federation of Pigment Cell Societies (IFPCS) held its XXIII triennial International Pigment Cell Conference (IPCC) in Denver, Colorado in August 2017. The goal of the summit was to provide a ...

    Authors: Neil F. Box, Lionel Larue, Prashiela Manga, Lluis Montoliu, Richard A. Spritz and Fabian V. Filipp

    Citation: Journal of Translational Medicine 2018 16:252

    Content type: Commentary

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  34. Acute myeloid leukemia (AML) is a highly heterogeneous disease. MicroRNAs function as important biomarkers in the clinical prognosis of AML.

    Authors: Chen Yang, Tingting Shao, Huihui Zhang, Ninghan Zhang, Xiaoying Shi, Xuejiao Liu, Yao Yao, Linyan Xu, Shengyun Zhu, Jiang Cao, Hai Cheng, Zhiling Yan, Zhenyu Li, Mingshan Niu and Kailin Xu

    Citation: Journal of Translational Medicine 2018 16:267

    Content type: Research

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  35. Enteroviral cardiomyopathy is a life-threatening disease, and detection of enterovirus (EV) RNA in the initial endomyocardial biopsy is associated with adverse prognosis and increased mortality. Some patients ...

    Authors: Dirk Lassner, Christine S. Siegismund, Uwe Kühl, Maria Rohde, Andrea Stroux, Felicitas Escher and Heinz-Peter Schultheiss

    Citation: Journal of Translational Medicine 2018 16:249

    Content type: Research

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  36. Although precision medicine has made advances in individualized patient treatments, there needs to be continued attention on tailored population health and prevention strategies (often termed “precision popula...

    Authors: Courtney R. Lyles, Mitchell R. Lunn, Juno Obedin-Maliver and Kirsten Bibbins-Domingo

    Citation: Journal of Translational Medicine 2018 16:211

    Content type: Commentary

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  37. UDP-glucuronosyltransferase 1A subfamily (UGT1A) enzymes can inactivate cytarabine (Ara-C) by glucuronidation, and thus serves as candidate genes for interindividual difference in Ara-C response. UGT1A1 is a m...

    Authors: Peng Chen, Ke-Wei Zhu, Dao-Yu Zhang, Han Yan, Han Liu, Yan-Ling Liu, Shan Cao, Gan Zhou, Hui Zeng, Shu-Ping Chen, Xie-Lan Zhao, Jing Yang and Xiao-Ping Chen

    Citation: Journal of Translational Medicine 2018 16:197

    Content type: Research

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  38. Germline mutations in the BRCA-1 associated tumor protein 1 (BAP1) increase susceptibility to mesothelioma and other cancers. We describe a patient with a family history of peritoneal mesothelioma, who develop...

    Authors: Muaiad Kittaneh and Charles Berkelhammer

    Citation: Journal of Translational Medicine 2018 16:194

    Content type: Review

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  39. Approximately 30% of rheumatoid arthritis (RA) patients treated with Tripterysium glycosides (TG) tablets fail to achieve clinical improvement, implying the essentiality of predictive biomarkers and tools. Her...

    Authors: Yanqiong Zhang, Hailong Wang, Xia Mao, Qiuyan Guo, Weijie Li, Xiaoyue Wang, Guangyao Li and Na Lin

    Citation: Journal of Translational Medicine 2018 16:187

    Content type: Research

    Published on:

  40. Carcinoma of unknown primary (CUP) is a metastatic epithelial malignancy in the absence of an identifiable primary tumour. Prognosis for patients with CUP is poor because treatment options are generally limite...

    Authors: B. Clynick, B. Dessauvagie, G. Sterrett, N. T. Harvey, R. J. N. Allcock, C. Saunders, W. Erber and K. Meehan

    Citation: Journal of Translational Medicine 2018 16:185

    Content type: Research

    Published on:

  41. A family history of breast cancer has long been thought to indicate the presence of inherited genetic events that predispose to this disease. In North Africa, many specific epidemio-genetic characteristics hav...

    Authors: Yosr Hamdi, Maroua Boujemaa, Mariem Ben Rekaya, Cherif Ben Hamda, Najah Mighri, Houda El Benna, Nesrine Mejri, Soumaya Labidi, Nouha Daoud, Chokri Naouali, Olfa Messaoud, Mariem Chargui, Kais Ghedira, Mohamed Samir Boubaker, Ridha Mrad, Hamouda Boussen…

    Citation: Journal of Translational Medicine 2018 16:158

    Content type: Research

    Published on:

  42. The biobanks, providers of biospecimens, and the scientists, users of biological material, are both strategic actors in translational medicine but the communication about those two subjects seems to be delicat...

    Authors: Angelo Virgilio Paradiso, Maria Grazia Daidone, Vincenzo Canzonieri and Alfredo Zito

    Citation: Journal of Translational Medicine 2018 16:136

    Content type: Commentary

    Published on:

  43. Actual European pathological classification of early-stage endometrial cancer (EC) may show insufficient accuracy to precisely stratify recurrence risk, leading to potential over or under treatment. Micro-RNAs...

    Authors: Tiphaine de Foucher, Maria Sbeih, Jenifer Uzan, Sofiane Bendifallah, Marine Lefevre, Nathalie Chabbert-Buffet, Selim Aractingi, Catherine Uzan, Issam Abd Alsalam, Rana Mitri, Romain H. Fontaine, Emile Daraï, Bassam Haddad, Céline Méhats, Marcos Ballester, Geoffroy Canlorbe…

    Citation: Journal of Translational Medicine 2018 16:131

    Content type: Research

    Published on:

  44. MicroRNAs (miRNAs) play an important role in cancer biology. Neoadjuvant radiochemotherapy followed by surgery is a standard treatment for locally advanced esophageal squamous cell carcinoma (ESCC). However, a...

    Authors: Julia Slotta-Huspenina, Enken Drecoll, Marcus Feith, Daniel Habermehl, Stephanie Combs, Wilko Weichert, Marcus Bettstetter, Karen Becker and Rupert Langer

    Citation: Journal of Translational Medicine 2018 16:109

    Content type: Research

    Published on:

    The Correction to this article has been published in Journal of Translational Medicine 2018 16:128

  45. The CYP2C19 nonfunctional genotype reduces clopidogrel effectiveness after percutaneous coronary intervention (PCI). Following clinical implementation of CYP2C19 genotyping at University Florida (UF) Health Shand...

    Authors: Larisa H. Cavallari, Francesco Franchi, Fabiana Rollini, Latonya Been, Andrea Rivas, Malhar Agarwal, D. Max Smith, Kimberly Newsom, Yan Gong, Amanda R. Elsey, Petr Starostik, Julie A. Johnson and Dominick J. Angiolillo

    Citation: Journal of Translational Medicine 2018 16:92

    Content type: Research

    Published on:

  46. Cytarabine arabinoside (Ara-C) has been the core of chemotherapy for adult acute myeloid leukemia (AML). Ara-C undergoes a three-step phosphorylation into the active metabolite Ara-C triphosphosphate (ara-CTP)...

    Authors: Ke-Wei Zhu, Peng Chen, Dao-Yu Zhang, Han Yan, Han Liu, Li-Na Cen, Yan-Ling Liu, Shan Cao, Gan Zhou, Hui Zeng, Shu-Ping Chen, Xie-Lan Zhao and Xiao-Ping Chen

    Citation: Journal of Translational Medicine 2018 16:90

    Content type: Research

    Published on:

  47. Primary pulmonary enteric adenocarcinoma (PEAC) is an extremely rare variant of invasive lung cancer. It is highly heterogeneous while shares some common morphologic and immunohistochemical features with usual...

    Authors: Ming Chen, Pu Liu, Feifei Yan, Suzhen Xu, Qi Jiang, Jingying Pan, Mengye He and Peng Shen

    Citation: Journal of Translational Medicine 2018 16:81

    Content type: Research

    Published on:

  48. Breast cancer is one of the most frequent malignancies and the second leading cause of cancer-related mortality in women. MicroRNAs play a key role in breast cancer development and progression. microRNA(miR)-8...

    Authors: Yujing Gao, Hongning Ma, Chanchan Gao, Ye Lv, XueHua Chen, Rongrong Xu, Miao Sun, Xinrui Liu, Xiaohong Lu, Xiuying Pei and Pu Li

    Citation: Journal of Translational Medicine 2018 16:38

    Content type: Research

    Published on:

  49. While the promise of the Human Genome Project provided significant insights into the structure of the human genome, the complexities of disease at the individual level have made it difficult to utilize –omic i...

    Authors: Patrick J. Silva, Valerie M. Schaibley and Kenneth S. Ramos

    Citation: Journal of Translational Medicine 2018 16:28

    Content type: Review

    Published on:

  50. Breast cancer brain metastases (BCBM) develop in about 20–30% of breast cancer (BC) patients. BCBM are associated with dismal prognosis not at least due to lack of valuable molecular therapeutic targets. The a...

    Authors: Hans-Juergen Schulten, Mohammed Bangash, Sajjad Karim, Ashraf Dallol, Deema Hussein, Adnan Merdad, Fatma K. Al-Thoubaity, Jaudah Al-Maghrabi, Awatif Jamal, Fahad Al-Ghamdi, Hani Choudhry, Saleh S. Baeesa, Adeel G. Chaudhary and Mohammed H. Al-Qahtani

    Citation: Journal of Translational Medicine 2017 15:269

    Content type: Research

    Published on:

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