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Cellular Metabolism Therapy

Section Edited by Salvatore Nesci

Cellular Metabolism Therapy aims to promote the translation of basic research emerging from biochemistry, molecular medicine, physiology and biotechnology into cell metabolism in order to be exploited in clinical applications. 

Studies considered for publication will cover any aspect of translational metabolic research, including (but not limited to): genetic disorders and epigenetic diseases; metabolic derangements causing neurodegeneration; immunometabolism; stroke; cardiovascular diseases; tumours; stem cell bioenergetics; ageing; carbohydrate, lipid, and protein metabolism.


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  1. The treatment of spinal cord injury (SCI) has always been a significant research focus of clinical neuroscience, with inhibition of microglia-mediated neuro-inflammation as well as oxidative stress key to succ...

    Authors: Yanan Zhang, Qian Deng, Hongxiang Hong, Zhanyang Qian, Bowen Wan and Mingjie Xia
    Citation: Journal of Translational Medicine 2024 22:304
  2. The mitochondria and endoplasmic reticulum (ER) communicate via contact sites known as mitochondria associated membranes (MAMs). Many important cellular functions such as bioenergetics, mitophagy, apoptosis, a...

    Authors: Yi Li, Hua-bin Wang, Jin-long Cao, Wen-jun Zhang, Hai-long Wang, Chang-hong Xu, Kun-peng Li, Yi Liu, Ji-rong Wang, Hua-lan Ha, Sheng-jun Fu and Li Yang
    Citation: Journal of Translational Medicine 2024 22:261
  3. Mitochondria produce adenosine triphosphate through respiratory activities to power sperm differentiation and motility, and decreased mitochondrial respiratory activity can result in poor sperm motility and as...

    Authors: Yining Liu, Tongtong Li, Mingze Shi, Yanling Wan, Hanzhen Li, Mingyu Zhang, Ziqi Wang, Shiyu Wang, Yue Lv, Gang Lu, Hongbin Liu, Haobo Zhang and Tao Huang
    Citation: Journal of Translational Medicine 2024 22:240
  4. Mitochondrial transplantation (MTx) has emerged as a novel therapeutic strategy, particularly effective in diseases characterized by mitochondrial dysfunction. This review synthesizes current knowledge on MTx,...

    Authors: Tomoaki Aoki, Yusuke Endo, Eriko Nakamura, Cyrus E. Kuschner, Jacob Kazmi, Parmeshar Singh, Tai Yin, Lance B. Becker and Kei Hayashida
    Citation: Journal of Translational Medicine 2024 22:230
  5. Non-alcoholic fatty liver disease (NAFLD) is becoming increasingly prevalent worldwide, emerging as a significant health issue on a global scale. Berberine exhibits potential for treating NAFLD, but clinical e...

    Authors: Qilong Nie, Mingyang Li, Caiyang Huang, Yongwei Yuan, Qiuyan Liang, Xiaojun Ma, Tengyu Qiu and Jianhong Li
    Citation: Journal of Translational Medicine 2024 22:225
  6. Cellular stress associated with static-cold storage (SCS) and warm reperfusion of donor lungs can contribute to ischemia–reperfusion (IR) injury during transplantation. Adding cytoprotective agents to the pres...

    Authors: Dejan Bojic, Tanroop Aujla, Junichi Sugihara, Aaron Wong, Shaf Keshavjee and Mingyao Liu
    Citation: Journal of Translational Medicine 2024 22:221
  7. Non-alcoholic fatty liver disease (NAFLD) is a multifaceted metabolic disorder, whose global prevalence is rapidly increasing. Acetyl CoA carboxylases 1 (ACACA) is the key enzyme that controls the rate of fatt...

    Authors: Jian Dong, Muzi Li, Runsheng Peng, Yuchuan Zhang, Zilin Qiao and Na Sun
    Citation: Journal of Translational Medicine 2024 22:196
  8. Targeting drugs to the mitochondrial level shows great promise for acute and chronic treatment of traumatic brain injury (TBI) in both military and civilian sectors. Perhaps the greatest obstacle to the succes...

    Authors: Jignesh D. Pandya, Sudeep Musyaju, Hiren R. Modi, Starlyn L. Okada-Rising, Zachary S. Bailey, Anke H. Scultetus and Deborah A. Shear
    Citation: Journal of Translational Medicine 2024 22:167
  9. The role of mitochondrial dynamics, encompassing fission, fusion, and mitophagy, in cancer progression has been extensively studied. However, the specific impact of mitochondrial dynamics on hepatocellular car...

    Authors: La Zhang, Xiuzhen Zhang, Haichuan Liu, Changhong Yang, Jiyao Yu, Wei Zhao, Jiao Guo, Baoyong Zhou and Ning Jiang
    Citation: Journal of Translational Medicine 2024 22:73
  10. Loss-of-function mutations in the PRKN gene, encoding Parkin, are the most common cause of autosomal recessive Parkinson’s disease (PD). We have previously identified mitoch

    Authors: Alessandra Zanon, Marianna Guida, Alexandros A. Lavdas, Corrado Corti, Maria Paulina Castelo Rueda, Alessandro Negro, Peter P. Pramstaller, Francisco S. Domingues, Andrew A. Hicks and Irene Pichler
    Citation: Journal of Translational Medicine 2024 22:59
  11. Heart transplantation (HT) has been approved as an optimal therapeutic regimen for patients with terminal-stage cardiac failure. However, cold ischaemia‒reperfusion (I/R) injury remains an unavoidable and outs...

    Authors: Shun Yuan, Yanjia Che, Zhiwei Wang, Kai Xing, Xiaoping Xie and Yuanyang Chen
    Citation: Journal of Translational Medicine 2023 21:925
  12. Metabolic dysfunction-associated fatty liver disease (MAFLD) is one of the most prevalent metabolic syndromes worldwide. However, no approved pharmacological treatments are available for MAFLD. Chenpi, one kin...

    Authors: Jing-wen Yang, Ying Zou, Jun Chen, Chen Cui, Jia Song, Meng-meng Yang, Jing Gao, Hui-qing Hu, Long-qing Xia, Li-ming Wang, Xiao-yu Lv, Li Chen and Xin-guo Hou
    Citation: Journal of Translational Medicine 2023 21:921
  13. SARS-CoV-2, the pathogen of COVID-19, is a worldwide threat to human health and causes a long-term burden on the cardiovascular system. Individuals with pre-existing cardiovascular diseases are at higher risk ...

    Authors: Shiyu Dai, Ting Cao, Han Shen, Xuejing Zong, Wenyu Gu, Hanghang Li, Lei Wei, Haoyue Huang, Yunsheng Yu, Yihuan Chen, Wenxue Ye, Fei Hua, Hongyou Fan and Zhenya Shen
    Citation: Journal of Translational Medicine 2023 21:915
  14. Osteosarcoma (OS) is the most common primary malignant bone tumor in children and adolescents, with poor outcomes for patients with metastatic disease or chemotherapy resistance. Cirsiliol is a recently found ...

    Authors: Mengliang Luo, Zexin Su, Haotian Gao, Jianye Tan, Rongdong Liao, Jiancheng Yang and Lijun Lin
    Citation: Journal of Translational Medicine 2023 21:907
  15. Right ventricle failure (RVF) is a progressive heart disease that has yet to be fully understood at the molecular level. Elevated M-type pyruvate kinase 2 (PKM2) tetramerization alleviates heart failure, but d...

    Authors: Lizhe Guo, Lu Wang, Gang Qin, Junjie Zhang, Jin Peng, Longyan Li, Xiang Chen, Dandan Wang, Jian Qiu and E. Wang
    Citation: Journal of Translational Medicine 2023 21:888
  16. Despite recent advances in locoregional, systemic, and novel checkpoint inhibitor treatment, hepatocellular carcinoma (HCC) is still associated with poor prognosis. The feasibility of potentially curative live...

    Authors: Dominik T. Koch, Haochen Yu, Iris Beirith, Malte Schirren, Moritz Drefs, Yunfei Liu, Mathilda Knoblauch, Dionysios Koliogiannis, Weiwei Sheng, Enrico N. De Toni, Alexandr V. Bazhin, Bernhard W. Renz, Markus O. Guba, Jens Werner and Matthias Ilmer
    Citation: Journal of Translational Medicine 2023 21:876
  17. Mammalian intestinal epithelium constantly undergoes rapid self-renewal and regeneration sustained by intestinal stem cells (ISCs) within crypts. Inducible nitric oxide synthase (iNOS) is an important regulato...

    Authors: Lingxiao Huang, Zhenni Xu, Xudan Lei, Yujun Huang, Siyu Tu, Lu Xu, Jieying Xia and Dengqun Liu
    Citation: Journal of Translational Medicine 2023 21:852
  18. Activated osteoclasts cause excessive bone resorption, and disrupt bone homeostasis, leading to osteoporosis. The extracellular signal-regulated kinase (ERK) signaling is the classical pathway related to osteo...

    Authors: Tao Yang, Weiwei Chen, Kai Gan, Chaofeng Wang, Xiaoxiao Xie, Yuangang Su, Haoyu Lian, Jiake Xu, Jinmin Zhao and Qian Liu
    Citation: Journal of Translational Medicine 2023 21:839
  19. Doxorubicin (DOX)-induced cardiotoxicity (DIC) is a major impediment to its clinical application. It is indispensable to explore alternative treatment molecules or drugs for mitigating DIC. WGX50, an organic e...

    Authors: Panpan Tai, Xinyu Chen, Guihua Jia, Guanjun Chen, Lian Gong, Yaxin Cheng, Zhuan Li, Heng Wang, Aiyan Chen, Ganghua Zhang, Yuxing Zhu, Mengqing Xiao, Zhanwang Wang, Yunqing Liu, Dongyong Shan, Dong He…
    Citation: Journal of Translational Medicine 2023 21:823
  20. Rett syndrome is a neuropediatric disease occurring due to mutations in MECP2 and characterized by a regression in the neuronal development following a normal postnatal growth, which results in the loss of acquir...

    Authors: Uliana Musokhranova, Cristina Grau, Cristina Vergara, Laura Rodríguez-Pascau, Clara Xiol, Alba A. Castells, Soledad Alcántara, Pilar Rodríguez-Pombo, Pilar Pizcueta, Marc Martinell, Angels García-Cazorla and Alfonso Oyarzábal
    Citation: Journal of Translational Medicine 2023 21:756
  21. Copper (Cu) is an essential element that is involved in a variety of biochemical processes. Both deficiency and accumulation of Cu are associated with various diseases; and a high amount of accumulated Cu in c...

    Authors: Mojtaba Tarin, Maryam Babaie, Hossein Eshghi, Maryam M. Matin and Amir Sh. Saljooghi
    Citation: Journal of Translational Medicine 2023 21:745
  22. Colorectal cancer (CRC) is one of the most common malignant tumors globally, with high morbidity and mortality. Endoplasmic reticulum is a major organelle responsible for protein synthesis, processing, and tra...

    Authors: Hufei Wang, Zhi Li, Yangbao Tao, Suwen Ou, Jinhua Ye, Songlin Ran, Kangjia Luo, Zilong Guan, Jun Xiang, Guoqing Yan, Yang Wang, Tianyi Ma, Shan Yu, Yanni Song and Rui Huang
    Citation: Journal of Translational Medicine 2023 21:713
  23. Extracellular matrix stiffness is emerging as a crucial mechanical cue that drives the progression of various diseases, such as cancer, fibrosis, and inflammation. The matrix stiffness of the nucleus pulposus ...

    Authors: Wencan Ke, Bingjin Wang, Zhiwei Liao, Yu Song, Gaocai Li, Liang Ma, Kun Wang, Shuai Li, Wenbin Hua and Cao Yang
    Citation: Journal of Translational Medicine 2023 21:711
  24. Breast cancer is, despite screening, not always detected early enough and is together with other tumor types known to shed genetic information in circulation. Unlike single-copy nuclear DNA, mitochondrial DNA ...

    Authors: Yanni Li, Kristina Sundquist, Sakshi Vats, Mun-Gwan Hong, Xiao Wang, Yilun Chen, Anna Hedelius, Lao H. Saal, Jan Sundquist and Ashfaque A. Memon
    Citation: Journal of Translational Medicine 2023 21:696
  25. Cisplatin is a widely used and effective chemotherapeutic agent against cancer. However, nephrotoxicity is one of the most common side effects of cisplatin, and it can proceed to acute kidney injury (AKI). Stu...

    Authors: Fei Deng, Heping Zhang, Wei Zhou, Shijie Ma, Yuwei Kang, Wei Yang, Liangbin Zhao and Wei Qin
    Citation: Journal of Translational Medicine 2023 21:695
  26. A large body of evidence indicates the existence of a complex pathophysiological relationship between cardiovascular diseases and cancer. Mitochondria are crucial organelles whose optimal activity is determine...

    Authors: Carmine Rocca, Teresa Soda, Ernestina Marianna De Francesco, Marco Fiorillo, Francesco Moccia, Giuseppe Viglietto, Tommaso Angelone and Nicola Amodio
    Citation: Journal of Translational Medicine 2023 21:635
  27. Mitochondrial dysfunction is reiteratively involved in the pathogenesis of diverse neurodegenerative diseases. Current in vitro and in vivo approaches support that mitochondrial dysfunction is branded by sever...

    Authors: Felipe A. Bustamante-Barrientos, Noymar Luque-Campos, María Jesús Araya, Eliana Lara-Barba, Javiera de Solminihac, Carolina Pradenas, Luis Molina, Yeimi Herrera-Luna, Yildy Utreras-Mendoza, Roberto Elizondo-Vega, Ana María Vega-Letter and Patricia Luz-Crawford
    Citation: Journal of Translational Medicine 2023 21:613
  28. Fabry disease (FD) is a rare lysosomal storage disorder caused by mutations in the GLA gene, resulting in reduced or lack of α-galactosidase A activity. This results in the accumulation of globotriaosylceramid...

    Authors: Hassan Osman Alhassan Elsaid, Mariell Rivedal, Eleni Skandalou, Einar Svarstad, Camilla Tøndel, Even Birkeland, Øystein Eikrem, Janka Babickova, Hans-Peter Marti and Jessica Furriol
    Citation: Journal of Translational Medicine 2023 21:591
  29. Lower-grade glioma (LGG) is a highly heterogeneous disease that presents challenges in accurately predicting patient prognosis. Mitochondria play a central role in the energy metabolism of eukaryotic cells and...

    Authors: Hu Qin, Aimitaji Abulaiti, Aierpati Maimaiti, Zulihuma Abulaiti, Guofeng Fan, Yirizhati Aili, Wenyu Ji, Zengliang Wang and Yongxin Wang
    Citation: Journal of Translational Medicine 2023 21:588
  30. Human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) are seed cells that can be used for alternative treatment of myocardial damage. However, their immaturity limits their clinical applicatio...

    Authors: Huiwen Liu, Li Wang, Hao Xu, Bin Tan, Qin Yi, Hongrong Deng, Yunxia Chen, Bolin He, Jie Tian and Jing Zhu
    Citation: Journal of Translational Medicine 2023 21:581
  31. Benign prostatic hyperplasia (BPH) is a common disease in elderly men, mainly resulted from an imbalance between cell proliferation and death. Glutathione peroxidase 3 (GPX3) was one of the differentially expr...

    Authors: Yan Li, Yongying Zhou, Daoquan Liu, Zhen Wang, Jizhang Qiu, Junchao Zhang, Ping Chen, Guang Zeng, Yuming Guo, Xinghuan Wang, Michael E. DiSanto and Xinhua Zhang
    Citation: Journal of Translational Medicine 2023 21:575
  32. Rheumatoid arthritis (RA) is an autoimmune disease that exhibits a high degree of heterogeneity, marked by unpredictable disease flares and significant variations in the response to available treatments. The l...

    Authors: Qi Wang, Qi-Chao Gao, Qi-Chuan Wang, Li Wu, Qi Yu and Pei-Feng He
    Citation: Journal of Translational Medicine 2023 21:561
  33. Peripheral nerve injury can cause neuroinflammation and neuromodulation that lead to mitochondrial dysfunction and neuronal apoptosis in the dorsal root ganglion (DRG) and spinal cord, contributing to neuropat...

    Authors: Yaseen Awad-Igbaria, Nadine Ferreira, Ali Keadan, Reem Sakas, Doron Edelman, Alon Shamir, Jean Francous-Soustiel and Eilam Palzur
    Citation: Journal of Translational Medicine 2023 21:545
  34. Glioblastoma (GBM) is a brain tumor with the highest level of malignancy and the worst prognosis in the central nervous system. Mitochondrial metabolism plays a vital role in the occurrence and development of ...

    Authors: Tongxuan Guo, Changyong Wu, Lingni Zhou, Junhao Zhang, Wanzhou Wang, Yang Shen, Ludong Zhang, Mingshan Niu, Xu Zhang, Rutong Yu and Xuejiao Liu
    Citation: Journal of Translational Medicine 2023 21:532
  35. Colorectal cancer (CRC) can be classified into four molecular subtypes (CMS) among which CMS1 is associated with the best prognosis, while CMS4, the mesenchymal subtype, has the worst outcome. Although mitocho...

    Authors: Jean Bastin, Marine Sroussi, Ivan Nemazanyy, Pierre Laurent-Puig, Sophie Mouillet-Richard and Fatima Djouadi
    Citation: Journal of Translational Medicine 2023 21:522
  36. Mitochondria are the only organelles regulated by two genomes. The coordinated translation of nuclear DNA (nDNA) and mitochondrial DNA (mtDNA), which together co-encode the subunits of the oxidative phosphoryl...

    Authors: Jiaoyan Ma, Liankun Sun, Weinan Gao, Yang Li and Delu Dong
    Citation: Journal of Translational Medicine 2023 21:512
  37. Metabolic dysfunction-associated fatty liver disease (MAFLD) is among the most widespread metabolic disease globally, and its associated complications including insulin resistance and diabetes have become thre...

    Authors: Youwei Zheng, Shiting Wang, Jialiang Wu and Yong Wang
    Citation: Journal of Translational Medicine 2023 21:510
  38. Mitochondria play important roles in maintaining cellular homeostasis and skeletal muscle health, and damage to mitochondria can lead to a series of pathophysiological changes. Mitochondrial dysfunction can le...

    Authors: Xin Chen, Yanan Ji, Ruiqi Liu, Xucheng Zhu, Kexin Wang, Xiaoming Yang, Boya Liu, Zihui Gao, Yan Huang, Yuntian Shen, Hua Liu and Hualin Sun
    Citation: Journal of Translational Medicine 2023 21:503
  39. Diabetes is associated with an increased risk of cognitive decline and dementia. These diseases are linked with mitochondrial dysfunction, most likely as a consequence of excessive formation of mitochondria-as...

    Authors: Yanmin Chang, Cailin Wang, Jiahui Zhu, Siyi Zheng, Shangqi Sun, Yanqing Wu, Xingjun Jiang, Lulu Li, Rong Ma and Gang Li
    Citation: Journal of Translational Medicine 2023 21:494
  40. Lipid metabolism plays an important role in liver regeneration, but its regulation still requires further research. In this study, lipid metabolites involved in mouse liver regeneration at different time point...

    Authors: Xi Zhou, Guobin Huang, Lu Wang, Yuanyuan Zhao, Junbo Li, Dong Chen, Lai Wei, Zhishui Chen and Bo Yang
    Citation: Journal of Translational Medicine 2023 21:487
  41. Sepsis-associated encephalopathy (SAE) is characterized by diffuse brain dysfunction, long-term cognitive impairment, and increased morbidity and mortality. The current treatment for SAE is mainly symptomatic;...

    Authors: Yuqiang Liu, Han Yang, Nanbo Luo, Yifei Fu, Fang Qiu, Zhenglong Pan, Xiongjuan Li, Wenling Jian, Xinping Yang, Qingsheng Xue, Yan Luo, Buwei Yu and Zhiheng Liu
    Citation: Journal of Translational Medicine 2023 21:486
  42. Bone regeneration therapy is clinically important, and targeted regulation of endoplasmic reticulum (ER) stress is important in regenerative medicine. The processing of proteins in the ER controls cell fate. T...

    Authors: Tingyu Wu, Yaping Jiang, Weipeng Shi, Yingzhen Wang and Tao Li
    Citation: Journal of Translational Medicine 2023 21:480
  43. Interleukin-1 receptor antagonist (IL-1RA), a member of the IL-1 family, has diverse roles in cancer development. However, the role of IL-1RA in oral squamous cell carcinoma (OSCC), in particular the underlyin...

    Authors: Shyng-Shiou F. Yuan, Yun-Ming Wang, Leong-Perng Chan, Amos C. Hung, Hieu D. H. Nguyen, Yuk-Kwan Chen, Stephen Chu‐Sung Hu, Steven Lo and Yen-Yun Wang
    Citation: Journal of Translational Medicine 2023 21:473
  44. Cell pyroptosis has a strong proinflammatory effect, but it is unclear whether pyroptosis of liver macrophages exacerbates liver tissue damage during liver ischemia‒reperfusion (I/R) injury. Maresin1 (MaR1) ha...

    Authors: Tong Li, Houshuai Zeng, Wenjing Xian, Hongxing Cai, Jianbo Zhang, Shiji Zhou, Yingxue Yang, Min Luo and Peng Zhu
    Citation: Journal of Translational Medicine 2023 21:472
  45. Pulmonary arterial hypertension (PAH) is a highly prevalent cardiopulmonary disorder characterized by vascular remodeling and increased resistance in pulmonary artery. Mitochondrial coiled–coil–helix–coiled–co...

    Authors: Yu Wang, Zhenyu Zeng, Zhaoxiang Zeng, Guojun Chu and Xinghua Shan
    Citation: Journal of Translational Medicine 2023 21:464
  46. Alzheimer's disease (AD) is the most common neurodegenerative disease. Mitochondrial dysfunction and immune responses are important factors in the pathogenesis of AD, but their crosstalk in AD has not been stu...

    Authors: Yaodan Zhang, Yuyang Miao, Jin Tan, Fanglian Chen, Ping Lei and Qiang Zhang
    Citation: Journal of Translational Medicine 2023 21:458
  47. Osteoarthritis (OA), in which macrophage-driven synovitis is considered closely related to cartilage destruction and could occur at any stage, is an inflammatory arthritis. However, there are no effective targ...

    Authors: Zhen Zhang, Shujun Xie, Jin Qian, Fengqiang Gao, Wenjian Jin, Lingqiao Wang, Lili Yan, Hao Chen, Wangxiang Yao, Maoqiang Li, Xuepeng Wang and Liulong Zhu
    Citation: Journal of Translational Medicine 2023 21:452
  48. Endothelial cells (ECs) angiogenesis is the process of sprouting new vessels from the existing ones, playing critical roles in physiological and pathological processes such as wound healing, placentation, isch...

    Authors: Zhen Luo, Jianbo Yao, Zhe Wang and Jianxiong Xu
    Citation: Journal of Translational Medicine 2023 21:441
  49. Inflammation and immune dysfunction with classically activated macrophages(M1) infiltration are important mechanisms in the progression of atherosclerosis (AS). Dynamin-related protein 1 (DRP1)-dependent mitoc...

    Authors: Ze-da-zhong Su, Chun-qiu Li, Hua-wei Wang, Min-ming Zheng and Qing-wei Chen
    Citation: Journal of Translational Medicine 2023 21:427