Skip to main content

Cellular Metabolism Therapy

Section Edited by Salvatore Nesci

Cellular Metabolism Therapy aims to promote the translation of basic research emerging from biochemistry, molecular medicine, physiology and biotechnology into cell metabolism in order to be exploited in clinical applications. 

Studies considered for publication will cover any aspect of translational metabolic research, including (but not limited to): genetic disorders and epigenetic diseases; metabolic derangements causing neurodegeneration; immunometabolism; stroke; cardiovascular diseases; tumours; stem cell bioenergetics; ageing; carbohydrate, lipid, and protein metabolism.


  1. Cardiovascular disease (CVD) is the leading cause of noncommunicable disease-related death worldwide, and effective therapeutic strategies against CVD are urgently needed. Mitochondria dysfunction involves in ...

    Authors: Mingchu Sun, Wenhua Jiang, Nan Mu, Zihui Zhang, Lu Yu and Heng Ma
    Citation: Journal of Translational Medicine 2023 21:347
    Content type: Review Published on:

  2. Malignant melanoma is one of the most common tumours and has the highest mortality rate of all types of skin cancers worldwide. Traditional and novel therapeutic approaches, including surgery, targeted therapy...

    Authors: Fei Du, Lu-han Yang, Jiao Liu, Jian Wang, Lianpeng Fan, Suwit Duangmano, Hao Liu, Minghua Liu, Jun Wang, Xiaolin Zhong, Zhuo Zhang and Fang Wang
    Citation: Journal of Translational Medicine 2023 21:345
    Content type: Review Published on:

  3. Interleukin-17A (IL-17A), a proinflammatory cytokine primarily secreted by Th17 cells, γδT cells and natural killer T (NKT) cells, performs essential roles in the microenvironment of certain inflammation-relat...

    Authors: Wen-Qing Feng, Yu-Chen Zhang, Zhuo-Qing Xu, Su-Yue Yu, Jian-ting Huo, Abudumaimaitijiang Tuersun, Min-Hua Zheng, Jing-Kun Zhao, Ya-Ping Zong and Ai-Guo Lu
    Citation: Journal of Translational Medicine 2023 21:335
    Content type: Research Published on:

  4. People with mitochondrial disease (MtD) are susceptible to metabolic decompensation and neurological symptom progression in response to an infection. Increasing evidence suggests that mitochondrial dysfunction...

    Authors: Emily B. Warren, Eliza M. Gordon-Lipkin, Foo Cheung, Jinguo Chen, Amrita Mukherjee, Richard Apps, John S. Tsang, Jillian Jetmore, Melissa L. Schlein, Shannon Kruk, Yuanjiu Lei, A. Phillip West and Peter J. McGuire
    Citation: Journal of Translational Medicine 2023 21:331
    Content type: Research Published on:

  5. Oral squamous cell carcinoma (OSCC) is one of the most prevalent and fatal oral cancers. Mitochondria-targeting therapies represent promising strategies against various cancers, but their applications in treat...

    Authors: Yafei Zhang, Bingqian Yang, Chengwei Tu, Yifan Ping, Shuhong Chen, Tong Wu, Zheyu Zhao, Yixin Mao, Zhan Yang, Zelin Cao, Jianmin Li, Kate Huang, Xi Ding, Gang Wu, Peng Zou, Zhennan Deng…
    Citation: Journal of Translational Medicine 2023 21:328
    Content type: Research Published on:

  6. Cervical cancer remains one of the most prevalent cancers worldwide. Accumulating evidence suggests that specificity protein 1 (Sp1) plays a pivotal role in tumour progression. The underlying role and mechanis...

    Authors: Xu Xu, Xiaona Wang, Qihui Chen, Aman Zheng, Donglu Li, Ziqi Meng, Xinran Li, Hanchen Cai, Wangzhi Li, Shiyuan Huang and Fan Wang
    Citation: Journal of Translational Medicine 2023 21:307
    Content type: Research Published on:

  7. Available literature documents that ischemic stroke can disrupt the morphology and function of mitochondria and that the latter in other disease models can be preserved by neuropilin-1 (NRP-1) via oxidative st...

    Authors: Ting Guo, Manli Chen, Ji Liu, Zengyu Wei, Jinjin Yuan, Wenwen Wu, Zhiyun Wu, Yongxing Lai, Zijun Zhao, Hongbin Chen and Nan Liu
    Citation: Journal of Translational Medicine 2023 21:297
    Content type: Research Published on:

  8. Immune-mediated rejection was the major cause of graft dysfunction. Although the advances in immunosuppressive agents have markedly reduced the incidence of T-cell-mediated rejection after transplantation. How...

    Authors: Yannan Zhang, Jiannan He, Zhe Yang, Haofeng Zheng, Haoxiang Deng, Zihuan Luo, Qipeng Sun and Qiquan Sun
    Citation: Journal of Translational Medicine 2023 21:295
    Content type: Research Published on:

  10. The Hypoxia inducible gene domain family member 2A (HIGD2A) protein is indispensable for the assembly of the mitochondrial respiratory supercomplex, which has been implicated in cell proliferation and cell sur...

    Authors: Kuiyuan Huang, Ziying Liu, Zhanglian Xie, Xiaoran Li, Haixing Zhang, Yu Chen, Yiran Wang, Zimo Lin, Chuanjiang Li, Hongyan Liu and Xiaoyong Zhang
    Citation: Journal of Translational Medicine 2023 21:253
    Content type: Research Published on:

  11. Lung adenocarcinoma (LUAD) is the most prevalent subtype of lung cancer with high morbidity and mortality rates. Due to the heterogeneity of LUAD, its characteristics remain poorly understood. Exploring the cl...

    Authors: Yichun Xu, Yong Yang, Yichao Wang, Jun Su, Tianlong Chan, Jiajing Zhou, Yi Gong, Ke Wang, Yifeng Gu, Congmeng Zhang, Guanjin Wu, Ling Bi, Xiong Qin and Junsong Han
    Citation: Journal of Translational Medicine 2023 21:250
    Content type: Research Published on:

    The Correction to this article has been published in Journal of Translational Medicine 2023 21:268

  12. Substantial evidence suggests that immunoproteasome is implicated in the various neurological diseases such as stroke, multiple sclerosis and neurodegenerative diseases. However, whether the immunoproteasome i...

    Authors: Xingyong Chen, Yanguang Mao, Yueting Guo, Dongyun Xiao, Zejing Lin, Yiyi Huang, Ying Chun Liu, Xu Zhang and Yinzhou Wang
    Citation: Journal of Translational Medicine 2023 21:226
    Content type: Research Published on:

  13. Both the crystalline and soluble forms of cholesterol increase macrophage secretion of interleukin 1β (IL-1β), aggravating the inflammatory response in atherosclerosis (AS). However, the link between cholester...

    Authors: Huanzhi Zhang, Ni Xia, Tingting Tang, Shaofang Nie, Lingfeng Zha, Min Zhang, Bingjie Lv, Yuzhi Lu, Jiao Jiao, Jingyong Li and Xiang Cheng
    Citation: Journal of Translational Medicine 2023 21:224
    Content type: Research Published on:

  14. Diabetic cardiomyopathy (DCM) has been considered as a major threat to health in individuals with diabetes. GrpE-like 2 (Grpel2), a nucleotide exchange factor, has been shown to regulate mitochondrial import p...

    Authors: Rongjin Yang, Xiaomeng Zhang, Yunyun Zhang, Yingfan Wang, Man Li, Yuancui Meng, Jianbang Wang, Xue Wen, Jun Yu and Pan Chang
    Citation: Journal of Translational Medicine 2023 21:200
    Content type: Research Published on:

  15. The incidence and mortality of gastric cancer ranks fifth and fourth worldwide among all malignancies, respectively. Accumulating evidences have revealed the close relationship between mitochondrial dysfunctio...

    Authors: Jingjia Chang, Hao Wu, Jin Wu, Ming Liu, Wentao Zhang, Yanfen Hu, Xintong Zhang, Jing Xu, Li Li, Pengfei Yu and Jianjun Zhu
    Citation: Journal of Translational Medicine 2023 21:191
    Content type: Research Published on:

  16. The inner membrane mitochondrial protein (IMMT) is a central unit of the mitochondrial contact site and cristae organizing system (MICOS). While researchers continue to demonstrate the physiological function o...

    Authors: Hung-Yu Lin, Hsing-Ju Wu and Pei-Yi Chu
    Citation: Journal of Translational Medicine 2023 21:189
    Content type: Research Published on:

  17. To explore the association between translocase of the inner mitochondrial membrane 13 (Timm13) and liver fibrosis.

    Authors: Xiaomin Liao, Xianxian Ruan, Xianbin Wu, Zhejun Deng, Shanyu Qin and Haixing Jiang
    Citation: Journal of Translational Medicine 2023 21:188
    Content type: Research Published on:

  18. Necroptosis of macrophages is a necessary element in reinforcing intrapulmonary inflammation during acute lung injury (ALI). However, the molecular mechanism that sparks macrophage necroptosis is still unclear...

    Authors: Wen-Jing Zhong, Jun Zhang, Jia-Xi Duan, Chen-Yu Zhang, Sheng-Chao Ma, Yu-Sheng Li, Nan-Shi-Yu Yang, Hui-Hui Yang, Jian-Bing Xiong, Cha-Xiang Guan, Zhi-Xing Jiang, Zhi-Jian You and Yong Zhou
    Citation: Journal of Translational Medicine 2023 21:179
    Content type: Research Published on:

  19. Mitochondria represent a major source of reactive oxygen species (ROS) in cells, and the direct increase in ROS content is the primary cause of oxidative stress, which plays an important role in tumor prolifer...

    Authors: Shiao Tong, Minqi Xia, Yang Xu, Qian Sun, Liguo Ye, Fanen Yuan, Yixuan Wang, Jiayang Cai, Zhang Ye and Daofeng Tian
    Citation: Journal of Translational Medicine 2023 21:136
    Content type: Research Published on:

  20. The incidence and mortality rate of gastrointestinal cancers are high worldwide. Increasing studies have illustrated that the occurrence, progression, metastasis and prognosis of cancers are intimately linked ...

    Authors: Weili Liu, Yuan Gao, Hua Li, Xinxing Wang, Min Jin, Zhiqiang Shen, Dong Yang, Xuelian Zhang, Zilin Wei, Zhaoli Chen and Junwen Li
    Citation: Journal of Translational Medicine 2023 21:107
    Content type: Research Published on:

  21. Diabetic cardiomyopathy (DCM) is one of the common cardiovascular complications of diabetes and a leading cause of death in diabetic patients. Mitochondrial metabolism and immune-inflammation are key for DCM p...

    Authors: Cheng Peng, Yanxiu Zhang, Xueyan Lang and Yao Zhang
    Citation: Journal of Translational Medicine 2023 21:66
    Content type: Research Published on:

  22. Although β-catenin signaling cascade is frequently altered in human cancers, targeting this pathway has not been approved for cancer treatment.

    Authors: Yuting Wu, Shuhui Yang, Luyang Han, Kezhuo Shang, Baohui Zhang, Xiaochen Gai, Weiwei Deng, Fangming Liu and Hongbing Zhang
    Citation: Journal of Translational Medicine 2023 21:50
    Content type: Research Published on:

  23. MOTS-c is a peptide encoded by the short open reading frame of the mitochondrial 12S rRNA gene. It is significantly expressed in response to stress or exercise and translocated to the nucleus, where it regulat...

    Authors: Wei Wan, Lieliang Zhang, Yue Lin, Xiuqing Rao, Xifeng Wang, Fuzhou Hua and Jun Ying
    Citation: Journal of Translational Medicine 2023 21:36
    Content type: Review Published on:

  24. The disruption of blood-brain barrier (BBB), predominantly made up by brain microvascular endothelial cells (BMECs), is one of the characteristics of Alzheimer’s disease (AD). Thus, improving BMEC function may...

    Authors: Can Wan, Xiao-Qi Liu, Mei Chen, Hui-Han Ma, Guang-Liang Wu, Li-Jun Qiao, Ye-Feng Cai and Shi-Jie Zhang
    Citation: Journal of Translational Medicine 2023 21:34
    Content type: Research Published on:

  25. Mitochondria determine the physiological status of most eukaryotes. Mitochondrial dynamics plays an important role in maintaining mitochondrial homeostasis, and the disorder in mitochondrial dynamics could aff...

    Authors: Ao-ran Liu, Zhi Lv, Zi-wei Yan, Xiao-yang Wu, Li-rong Yan, Li-ping Sun, Yuan Yuan and Qian Xu
    Citation: Journal of Translational Medicine 2023 21:27
    Content type: Review Published on:

  26. Myocardial infarction (MI) has recently accounted for more than one-third of global mortality. Multiple molecular pathological pathways, such as oxidative stress, inflammation, and mitochondrial dysfunction, h...

    Authors: Chanon Piamsiri, Chayodom Maneechote, Kewarin Jinawong, Busarin Arunsak, Titikorn Chunchai, Wichwara Nawara, Siriporn C Chattipakorn and Nipon Chattipakorn
    Citation: Journal of Translational Medicine 2023 21:16
    Content type: Research Published on:

  27. There is no available viable treatment for Sepsis-Induced Cardiomyopathy (SIC), a common sepsis complication with a higher fatality risk. The septic patients showed an abnormal activation of the renin angioten...

    Authors: Xin-Sen Chen, Jing-Rui Cui, Xiang-Long Meng, Shu-Hang Wang, Wei Wei, Yu-Lei Gao, Song-Tao Shou, Yan-Cun Liu and Yan-Fen Chai
    Citation: Journal of Translational Medicine 2023 21:2
    Content type: Research Published on:

  28. Myeloid-derived suppressor cells (MDSCs), which are immature heterogeneous bone marrow cells, have been described as potent immune regulators in human and murine cancer models. The distribution of MDSCs varies...

    Authors: Xiaoli Lou, Deyong Gao, Liyuan Yang, Yue Wang and Yanqiang Hou
    Citation: Journal of Translational Medicine 2023 21:1
    Content type: Review Published on:

  29. Mitochondrial autophagy maintains mitochondrial function and cellular homeostasis and plays a critical role in the pathological process of cerebral ischemia/reperfusion injury (CIRI). Whether Gypenoside XVII (...

    Authors: Weijie Xie, Ting Zhu, Shuxia Zhang and Xiaobo Sun
    Citation: Journal of Translational Medicine 2022 20:622
    Content type: Research Published on:

  30. Several metabolic disorders and malignancies are directly related to abnormal mitochondrial solute carrier family 25 (SLC25A) members activity. However, its biological role in pancreatic cancer (PC) is not ent...

    Authors: Qiang Zhang, Yubao Tang, Shuai Sun, Qiuyi Xie, Jie Yao, Xiaodong Wang, Jianjun Qian and Zhennan Li
    Citation: Journal of Translational Medicine 2022 20:592
    Content type: Research Published on:

  31. Myocardial dysfunction played a vital role in organ damage after sepsis. Fluid resuscitation was the essential treatment in which Lactate Ringer's solution (LR) was commonly used. Since LR easily led to hyperl...

    Authors: Lei Tan, Han She, Jie Zheng, Xiaoyong Peng, Ningke Guo, Bindan Zhang, Yue Sun, Chunhua Ma, Shenglian Xu, Daiqin Bao, Yuanqun Zhou, Qinghui Li, Qingxiang Mao, Liangming Liu, Yi Hu and Tao Li
    Citation: Journal of Translational Medicine 2022 20:591
    Content type: Research Published on:

  32. Mitochondrial dysfunction is an important pathogenic event in acute kidney injury (AKI). GCN5L1 is a specific acetyltransferase in mitochondria, which regulates glucose and fatty acid metabolism. However, the ...

    Authors: Tingting Lv, Yu Zhang, XingZhao Ji, Shengnan Sun, Li Xu, Weixia Ma, Yi Liu and Qiang Wan
    Citation: Journal of Translational Medicine 2022 20:571
    Content type: Research Published on:

  33. Mitochondrial diseases (MD) are a heterogeneous group of multisystem disorders involving metabolic errors. MD are characterized by extremely heterogeneous symptoms, ranging from organ-specific to multisystem d...

    Authors: Vladislav O. Soldatov, Marina V. Kubekina, Marina Yu. Skorkina, Andrei E. Belykh, Tatiana V. Egorova, Mikhail V. Korokin, Mikhail V. Pokrovskiy, Alexey V. Deykin and Plamena R. Angelova
    Citation: Journal of Translational Medicine 2022 20:562
    Content type: Review Published on:

    The Correction to this article has been published in Journal of Translational Medicine 2023 21:96

  34. Destruction of articular cartilage and bone is the main cause of joint dysfunction in rheumatoid arthritis (RA). Acid-sensing ion channel 1a (ASIC1a) is a key molecule that mediates the destruction of RA artic...

    Authors: Zhuoyan Zai, Yayun Xu, Xuewen Qian, Zihan Li, Ziyao Ou, Tao Zhang, Longfei Wang, Yian Ling, Xiaoqing Peng, Yihao Zhang and Feihu Chen
    Citation: Journal of Translational Medicine 2022 20:561
    Content type: Research Published on:

  35. The COVID-19 pandemic has become a huge threat to human health, infecting millions of people worldwide and causing enormous economic losses. Many novel small molecule drugs have been developed to treat patient...

    Authors: Keyu Kong, Yongyun Chang, Hua Qiao, Chen Zhao, Xuzhuo Chen, Kewei Rong, Pu Zhang, Minghao Jin, Jingwei Zhang, Huiwu Li and Zanjing Zhai
    Citation: Journal of Translational Medicine 2022 20:549
    Content type: Research Published on:

  36. Sepsis-associated encephalopathy (SAE) is one of the most common types of sepsis-related organ dysfunction without overt central nervous system (CNS) infection. It is associated with higher mortality, low qual...

    Authors: John Sieh Dumbuya, Siqi Li, Lili Liang, Yanchen Chen, Jiang Du and Qiyi Zeng
    Citation: Journal of Translational Medicine 2022 20:546
    Content type: Research Published on:

  37. Metabolic diseases, including obesity, diabetes, and nonalcoholic fatty liver disease (NAFLD), are rising in both incidence and prevalence and remain a major global health and socioeconomic burden in the twent...

    Authors: Yifei Chen, Fuji Yang, Ying Chu, Zhihua Yun, Yongmin Yan and Jianhua Jin
    Citation: Journal of Translational Medicine 2022 20:483
    Content type: Review Published on:

  38. Explanted livers from patients with inherited metabolic liver diseases possess the potential to be a cell source of good-quality hepatocytes for hepatocyte transplantation (HT). This study evaluated the therap...

    Authors: Guang-Peng Zhou, Shi-Peng Li, Yi-Zhou Jiang, Jie Sun, Yu-Le Tan, Zhi-Gui Zeng, Lin Wei, Wei Qu, Li-Ying Sun and Zhi-Jun Zhu
    Citation: Journal of Translational Medicine 2022 20:479
    Content type: Research Published on:

  39. Adipose tissue-derived adipokines are involved in various crosstalk between adipose tissue and other organs. Omentin1, a novel adipokine, exerts vital roles in the maintenance of body metabolism, insulin resis...

    Authors: Jingui Hu, Tao Liu, Fei Fu, Zekun Cui, Qiong Lai, Yuanyuan Zhang, Boyang Yu, Fuming Liu, Junping Kou and Fang Li
    Citation: Journal of Translational Medicine 2022 20:447
    Content type: Research Published on:

  40. Glioblastoma (GBM) is the most common primary malignant brain tumor that leads to lethality. Several studies have demonstrated that mitochondria play an important role in GBM and that mitochondria-related gene...

    Authors: Jun Su, Yue Li, Qing Liu, Gang Peng, Chaoying Qin and Yang Li
    Citation: Journal of Translational Medicine 2022 20:440
    Content type: Research Published on:

Journal of Translational Medicine

ISSN: 1479-5876

Contact us