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Cellular Metabolism Therapy

Section Edited by Salvatore Nesci

Cellular Metabolism Therapy aims to promote the translation of basic research emerging from biochemistry, molecular medicine, physiology and biotechnology into cell metabolism in order to be exploited in clinical applications. 

Studies considered for publication will cover any aspect of translational metabolic research, including (but not limited to): genetic disorders and epigenetic diseases; metabolic derangements causing neurodegeneration; immunometabolism; stroke; cardiovascular diseases; tumours; stem cell bioenergetics; ageing; carbohydrate, lipid, and protein metabolism.


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  1. Sorafenib resistance is becoming increasingly common and disadvantageous for hepatocellular carcinoma (HCC) treatment. Ferroptosis is an iron dependent programmed cell death underlying the mechanism of sorafen...

    Authors: Xiuya Hu, Peiyu Zhang, Sai Li, Jiaqi Zhang, Danni Wang, Zihan Wang, Lu Zhu and Lingdi Wang
    Citation: Journal of Translational Medicine 2024 22:593
  2. Acute myocardial infarction (AMI) is a serious condition that occurs when part of the heart is subjected to ischemia episodes, following partial or complete occlusion of the epicardial coronary arteries. The r...

    Authors: Esther Densu Agyapong, Gaia Pedriali, Daniela Ramaccini, Esmaa Bouhamida, Elena Tremoli, Carlotta Giorgi, Paolo Pinton and Giampaolo Morciano
    Citation: Journal of Translational Medicine 2024 22:552
  3. Inflammation and endothelial barrier dysfunction are the major pathophysiological changes in acute respiratory distress syndrome (ARDS). Sphingosine-1-phosphate receptor 3 (S1PR3), a G protein-coupled receptor...

    Authors: Junnan Peng, Rui Tang, Jing He, Qian Yu, Daoxin Wang and Di Qi
    Citation: Journal of Translational Medicine 2024 22:535
  4. Given the insidious and high-fatality nature of cardiovascular diseases (CVDs), the emergence of fluoride as a newly identified risk factor demands serious consideration alongside traditional risk factors. Whi...

    Authors: Yan-Shu Li, Ru-Ru Yang, Xin-Ying Li, Wei-Wei Liu, Yi-Ming Zhao, Ming-Man Zu, Yi-Hong Gao, Min-Qi Huo, Yu-Ting Jiang and Bing-Yun Li
    Citation: Journal of Translational Medicine 2024 22:528
  5. Acetaminophen (APAP)-induced liver injury (AILI) is a pressing public health concern. Although evidence suggests that Bifidobacterium adolescentis (B. adolescentis) can be used to treat liver disease, it is uncle...

    Authors: Ping Qin, Yanru Li, Yangjing Su, Ze Wang, Rong Wu, Xiaoqi Liang, Yunong Zeng, Peiheng Guo, Zhichao Yu, Xintao Huang, Hong Yang, Zhenhua Zeng, Xiaoshan Zhao, Shenhai Gong, Jiaochan Han, Zhongqing Chen…
    Citation: Journal of Translational Medicine 2024 22:525
  6. As a key factor in determining testis size and sperm number, sertoli cells (SCs) play a crucial role in male infertility. Heat stress (HS) reduces SCs counts, negatively impacting nutrient transport and supply...

    Authors: Yu Hu, Nan Jian Luo, Lu Gan, Hong Yan Xue, Ke Yan Luo, Jiao Jiao Zhang and Xian Zhong Wang
    Citation: Journal of Translational Medicine 2024 22:501
  7. Myocardial ischemia-reperfusion injury (MIRI) is caused by reperfusion after ischemic heart disease. LncRNA Snhg1 regulates the progression of various diseases. N6-methyladenosine (m6A) is the frequent RNA modifi...

    Authors: Linlin Liu, Jiahong Wu, Cheng Lu, Yan Ma, Jiayi Wang, Jie Xu, Xiaoli Yang, Xuan Zhang, Hua Wang, Jieyu Xu and Jiehan Zhang
    Citation: Journal of Translational Medicine 2024 22:499
  8. Intercellular mitochondrial transfer (MT) is a newly discovered form of cell-to-cell signalling involving the active incorporation of healthy mitochondria into stressed/injured recipient cells, contributing to...

    Authors: Roberto Iorio, Sabrina Petricca, Vincenzo Mattei and Simona Delle Monache
    Citation: Journal of Translational Medicine 2024 22:491
  9. Mild therapeutic hypothermia (MTH) is an important method for perioperative prevention and treatment of myocardial ischemia–reperfusion injury (MIRI). Modifying mitochondrial proteins after protein translation...

    Authors: Wei Deng, Yixuan Chen, Jing Zhang, Jitao Ling, Zhou Xu, Zicheng Zhu, Xiaoyi Tang, Xiao Liu, Deju Zhang, Hong Zhu, Haili Lang, Lieliang Zhang, Fuzhou Hua, Shuchun Yu, Kejian Qian and Peng Yu
    Citation: Journal of Translational Medicine 2024 22:489
  10. Ulcerative colitis (UC) is an idiopathic, chronic inflammatory condition of the colon, characterized by repeated attacks, a lack of effective treatment options, and significant physical and mental health compl...

    Authors: Yue-Rong Tan, Si-Yang Shen, Xin-Yi Li, Peng-Fei Yi, Ben-Dong Fu and Lu-Yuan Peng
    Citation: Journal of Translational Medicine 2024 22:488
  11. The maintenance of mitochondrial homeostasis is critical for tumor initiation and malignant progression because it increases tumor cell survival and growth. The molecular events controlling mitochondrial integ...

    Authors: Kun Jiao, Guiqin Xu, Yun Liu, Zhaojuan Yang, Lvzhu Xiang, Zehong Chen, Chen Xu, You Zuo, Zhibai Wu, Ningqian Zheng, Wangjie Xu, Li Zhang and Yongzhong Liu
    Citation: Journal of Translational Medicine 2024 22:485
  12. Disturbance in mitochondrial homeostasis within proximal tubules is a critical characteristic associated with diabetic kidney disease (DKD). CaMKKβ/AMPK signaling plays an important role in regulating mitochon...

    Authors: Fei Han, Shi Wu, Ya Dong, Yanjie Liu, Bei Sun and Liming Chen
    Citation: Journal of Translational Medicine 2024 22:465
  13. Inherited deficiency of thymidine phosphorylase (TP), encoded by TYMP, leads to a rare disease with multiple mitochondrial DNA (mtDNA) abnormalities, mitochondrial neurogastrointestinal encephalomyopathy (MNGIE)....

    Authors: Jixiang Du, Fuchen Liu, Xihan Liu, Dandan Zhao, Dongdong Wang, Hongsheng Sun, Chuanzhu Yan and Yuying Zhao
    Citation: Journal of Translational Medicine 2024 22:449
  14. Biological-derived hydroxyapatite is widely used as a bone substitute for addressing bone defects, but its limited osteoconductive properties necessitate further improvement. The osteo-immunomodulatory propert...

    Authors: Kaidi Chen, Seongmin Ha, Leyao Xu, Chengwu Liu, Yuanxiang Liu, Xiayi Wu, Zhipeng Li, Shiyu Wu, Bo Yang and Zhuofan Chen
    Citation: Journal of Translational Medicine 2024 22:437
  15. Subarachnoid hemorrhage (SAH) represents a form of cerebrovascular event characterized by a notable mortality and morbidity rate. Fibroblast growth factor 21 (FGF21), a versatile hormone predominantly synthesi...

    Authors: Yue Ma, Zhiqin Liu, Lele Deng, Jingjing Du, Zenghui Fan, Tian Ma, Jing Xiong, Xue Xiuyun, Naibing Gu, Zhengli Di and Yu Zhang
    Citation: Journal of Translational Medicine 2024 22:436
  16. Glioblastoma is an aggressive brain tumor linked to significant angiogenesis and poor prognosis. Anti-angiogenic therapies with vascular endothelial growth factor receptor 2 (VEGFR2) inhibition have been inves...

    Authors: Min Guo, Junhao Zhang, Jiang Han, Yingyue Hu, Hao Ni, Juan Yuan, Yang Sun, Meijuan Liu, Lifen Gao, Wangjun Liao, Chunhong Ma, Yaou Liu, Shuijie Li and Nailin Li
    Citation: Journal of Translational Medicine 2024 22:419
  17. The progression of diabetic cardiomyopathy (DCM) is noticeably influenced by mitochondrial dysfunction. Variants of caveolin 3 (CAV3) play important roles in cardiovascular diseases. However, the potential rol...

    Authors: Ping Guo, Shuiqing Hu, Xiaohui Liu, Miaomiao He, Jie Li, Tingqiong Ma, Man Huang, Qin Fang and Yan Wang
    Citation: Journal of Translational Medicine 2024 22:390
  18. Interleukin-33 (IL-33), an emerging cytokine within the IL-1 family, assumes a pivotal function in the control of obesity. However, the specific mechanism of its regulation of obesity formation remains unclear...

    Authors: Danning Xu, Siqi Zhuang, Hongzhi Chen, Mengjie Jiang, Ping Jiang, Qian Wang, Xuemei Wang, Ruohong Chen, Haoneng Tang and Lingli Tang
    Citation: Journal of Translational Medicine 2024 22:363
  19. Acute pancreatitis (AP) is a clinically common acute abdominal disease, whose pathogenesis remains unclear. The severe patients usually have multiple complications and lack specific drugs, leading to a high mo...

    Authors: Kaige Yang, Rongli Xie, Guohui Xiao, Zhifeng Zhao, Min Ding, Tingyu Lin, Yiu Sing Tsang, Ying Chen, Dan Xu and Jian Fei
    Citation: Journal of Translational Medicine 2024 22:346
  20. The treatment of spinal cord injury (SCI) has always been a significant research focus of clinical neuroscience, with inhibition of microglia-mediated neuro-inflammation as well as oxidative stress key to succ...

    Authors: Yanan Zhang, Qian Deng, Hongxiang Hong, Zhanyang Qian, Bowen Wan and Mingjie Xia
    Citation: Journal of Translational Medicine 2024 22:304
  21. The mitochondria and endoplasmic reticulum (ER) communicate via contact sites known as mitochondria associated membranes (MAMs). Many important cellular functions such as bioenergetics, mitophagy, apoptosis, a...

    Authors: Yi Li, Hua-bin Wang, Jin-long Cao, Wen-jun Zhang, Hai-long Wang, Chang-hong Xu, Kun-peng Li, Yi Liu, Ji-rong Wang, Hua-lan Ha, Sheng-jun Fu and Li Yang
    Citation: Journal of Translational Medicine 2024 22:261
  22. Mitochondria produce adenosine triphosphate through respiratory activities to power sperm differentiation and motility, and decreased mitochondrial respiratory activity can result in poor sperm motility and as...

    Authors: Yining Liu, Tongtong Li, Mingze Shi, Yanling Wan, Hanzhen Li, Mingyu Zhang, Ziqi Wang, Shiyu Wang, Yue Lv, Gang Lu, Hongbin Liu, Haobo Zhang and Tao Huang
    Citation: Journal of Translational Medicine 2024 22:240
  23. Mitochondrial transplantation (MTx) has emerged as a novel therapeutic strategy, particularly effective in diseases characterized by mitochondrial dysfunction. This review synthesizes current knowledge on MTx,...

    Authors: Tomoaki Aoki, Yusuke Endo, Eriko Nakamura, Cyrus E. Kuschner, Jacob Kazmi, Parmeshar Singh, Tai Yin, Lance B. Becker and Kei Hayashida
    Citation: Journal of Translational Medicine 2024 22:230
  24. Non-alcoholic fatty liver disease (NAFLD) is becoming increasingly prevalent worldwide, emerging as a significant health issue on a global scale. Berberine exhibits potential for treating NAFLD, but clinical e...

    Authors: Qilong Nie, Mingyang Li, Caiyang Huang, Yongwei Yuan, Qiuyan Liang, Xiaojun Ma, Tengyu Qiu and Jianhong Li
    Citation: Journal of Translational Medicine 2024 22:225
  25. Cellular stress associated with static-cold storage (SCS) and warm reperfusion of donor lungs can contribute to ischemia–reperfusion (IR) injury during transplantation. Adding cytoprotective agents to the pres...

    Authors: Dejan Bojic, Tanroop Aujla, Junichi Sugihara, Aaron Wong, Shaf Keshavjee and Mingyao Liu
    Citation: Journal of Translational Medicine 2024 22:221
  26. Non-alcoholic fatty liver disease (NAFLD) is a multifaceted metabolic disorder, whose global prevalence is rapidly increasing. Acetyl CoA carboxylases 1 (ACACA) is the key enzyme that controls the rate of fatt...

    Authors: Jian Dong, Muzi Li, Runsheng Peng, Yuchuan Zhang, Zilin Qiao and Na Sun
    Citation: Journal of Translational Medicine 2024 22:196
  27. Targeting drugs to the mitochondrial level shows great promise for acute and chronic treatment of traumatic brain injury (TBI) in both military and civilian sectors. Perhaps the greatest obstacle to the succes...

    Authors: Jignesh D. Pandya, Sudeep Musyaju, Hiren R. Modi, Starlyn L. Okada-Rising, Zachary S. Bailey, Anke H. Scultetus and Deborah A. Shear
    Citation: Journal of Translational Medicine 2024 22:167
  28. The role of mitochondrial dynamics, encompassing fission, fusion, and mitophagy, in cancer progression has been extensively studied. However, the specific impact of mitochondrial dynamics on hepatocellular car...

    Authors: La Zhang, Xiuzhen Zhang, Haichuan Liu, Changhong Yang, Jiyao Yu, Wei Zhao, Jiao Guo, Baoyong Zhou and Ning Jiang
    Citation: Journal of Translational Medicine 2024 22:73
  29. Loss-of-function mutations in the PRKN gene, encoding Parkin, are the most common cause of autosomal recessive Parkinson’s disease (PD). We have previously identified mitoch

    Authors: Alessandra Zanon, Marianna Guida, Alexandros A. Lavdas, Corrado Corti, Maria Paulina Castelo Rueda, Alessandro Negro, Peter P. Pramstaller, Francisco S. Domingues, Andrew A. Hicks and Irene Pichler
    Citation: Journal of Translational Medicine 2024 22:59
  30. Heart transplantation (HT) has been approved as an optimal therapeutic regimen for patients with terminal-stage cardiac failure. However, cold ischaemia‒reperfusion (I/R) injury remains an unavoidable and outs...

    Authors: Shun Yuan, Yanjia Che, Zhiwei Wang, Kai Xing, Xiaoping Xie and Yuanyang Chen
    Citation: Journal of Translational Medicine 2023 21:925
  31. Metabolic dysfunction-associated fatty liver disease (MAFLD) is one of the most prevalent metabolic syndromes worldwide. However, no approved pharmacological treatments are available for MAFLD. Chenpi, one kin...

    Authors: Jing-wen Yang, Ying Zou, Jun Chen, Chen Cui, Jia Song, Meng-meng Yang, Jing Gao, Hui-qing Hu, Long-qing Xia, Li-ming Wang, Xiao-yu Lv, Li Chen and Xin-guo Hou
    Citation: Journal of Translational Medicine 2023 21:921
  32. SARS-CoV-2, the pathogen of COVID-19, is a worldwide threat to human health and causes a long-term burden on the cardiovascular system. Individuals with pre-existing cardiovascular diseases are at higher risk ...

    Authors: Shiyu Dai, Ting Cao, Han Shen, Xuejing Zong, Wenyu Gu, Hanghang Li, Lei Wei, Haoyue Huang, Yunsheng Yu, Yihuan Chen, Wenxue Ye, Fei Hua, Hongyou Fan and Zhenya Shen
    Citation: Journal of Translational Medicine 2023 21:915
  33. Osteosarcoma (OS) is the most common primary malignant bone tumor in children and adolescents, with poor outcomes for patients with metastatic disease or chemotherapy resistance. Cirsiliol is a recently found ...

    Authors: Mengliang Luo, Zexin Su, Haotian Gao, Jianye Tan, Rongdong Liao, Jiancheng Yang and Lijun Lin
    Citation: Journal of Translational Medicine 2023 21:907
  34. Right ventricle failure (RVF) is a progressive heart disease that has yet to be fully understood at the molecular level. Elevated M-type pyruvate kinase 2 (PKM2) tetramerization alleviates heart failure, but d...

    Authors: Lizhe Guo, Lu Wang, Gang Qin, Junjie Zhang, Jin Peng, Longyan Li, Xiang Chen, Dandan Wang, Jian Qiu and E. Wang
    Citation: Journal of Translational Medicine 2023 21:888
  35. Despite recent advances in locoregional, systemic, and novel checkpoint inhibitor treatment, hepatocellular carcinoma (HCC) is still associated with poor prognosis. The feasibility of potentially curative live...

    Authors: Dominik T. Koch, Haochen Yu, Iris Beirith, Malte Schirren, Moritz Drefs, Yunfei Liu, Mathilda Knoblauch, Dionysios Koliogiannis, Weiwei Sheng, Enrico N. De Toni, Alexandr V. Bazhin, Bernhard W. Renz, Markus O. Guba, Jens Werner and Matthias Ilmer
    Citation: Journal of Translational Medicine 2023 21:876
  36. Mammalian intestinal epithelium constantly undergoes rapid self-renewal and regeneration sustained by intestinal stem cells (ISCs) within crypts. Inducible nitric oxide synthase (iNOS) is an important regulato...

    Authors: Lingxiao Huang, Zhenni Xu, Xudan Lei, Yujun Huang, Siyu Tu, Lu Xu, Jieying Xia and Dengqun Liu
    Citation: Journal of Translational Medicine 2023 21:852
  37. Activated osteoclasts cause excessive bone resorption, and disrupt bone homeostasis, leading to osteoporosis. The extracellular signal-regulated kinase (ERK) signaling is the classical pathway related to osteo...

    Authors: Tao Yang, Weiwei Chen, Kai Gan, Chaofeng Wang, Xiaoxiao Xie, Yuangang Su, Haoyu Lian, Jiake Xu, Jinmin Zhao and Qian Liu
    Citation: Journal of Translational Medicine 2023 21:839
  38. Doxorubicin (DOX)-induced cardiotoxicity (DIC) is a major impediment to its clinical application. It is indispensable to explore alternative treatment molecules or drugs for mitigating DIC. WGX50, an organic e...

    Authors: Panpan Tai, Xinyu Chen, Guihua Jia, Guanjun Chen, Lian Gong, Yaxin Cheng, Zhuan Li, Heng Wang, Aiyan Chen, Ganghua Zhang, Yuxing Zhu, Mengqing Xiao, Zhanwang Wang, Yunqing Liu, Dongyong Shan, Dong He…
    Citation: Journal of Translational Medicine 2023 21:823
  39. Rett syndrome is a neuropediatric disease occurring due to mutations in MECP2 and characterized by a regression in the neuronal development following a normal postnatal growth, which results in the loss of acquir...

    Authors: Uliana Musokhranova, Cristina Grau, Cristina Vergara, Laura Rodríguez-Pascau, Clara Xiol, Alba A. Castells, Soledad Alcántara, Pilar Rodríguez-Pombo, Pilar Pizcueta, Marc Martinell, Angels García-Cazorla and Alfonso Oyarzábal
    Citation: Journal of Translational Medicine 2023 21:756
  40. Copper (Cu) is an essential element that is involved in a variety of biochemical processes. Both deficiency and accumulation of Cu are associated with various diseases; and a high amount of accumulated Cu in c...

    Authors: Mojtaba Tarin, Maryam Babaie, Hossein Eshghi, Maryam M. Matin and Amir Sh. Saljooghi
    Citation: Journal of Translational Medicine 2023 21:745
  41. Colorectal cancer (CRC) is one of the most common malignant tumors globally, with high morbidity and mortality. Endoplasmic reticulum is a major organelle responsible for protein synthesis, processing, and tra...

    Authors: Hufei Wang, Zhi Li, Yangbao Tao, Suwen Ou, Jinhua Ye, Songlin Ran, Kangjia Luo, Zilong Guan, Jun Xiang, Guoqing Yan, Yang Wang, Tianyi Ma, Shan Yu, Yanni Song and Rui Huang
    Citation: Journal of Translational Medicine 2023 21:713
  42. Extracellular matrix stiffness is emerging as a crucial mechanical cue that drives the progression of various diseases, such as cancer, fibrosis, and inflammation. The matrix stiffness of the nucleus pulposus ...

    Authors: Wencan Ke, Bingjin Wang, Zhiwei Liao, Yu Song, Gaocai Li, Liang Ma, Kun Wang, Shuai Li, Wenbin Hua and Cao Yang
    Citation: Journal of Translational Medicine 2023 21:711
  43. Breast cancer is, despite screening, not always detected early enough and is together with other tumor types known to shed genetic information in circulation. Unlike single-copy nuclear DNA, mitochondrial DNA ...

    Authors: Yanni Li, Kristina Sundquist, Sakshi Vats, Mun-Gwan Hong, Xiao Wang, Yilun Chen, Anna Hedelius, Lao H. Saal, Jan Sundquist and Ashfaque A. Memon
    Citation: Journal of Translational Medicine 2023 21:696
  44. Cisplatin is a widely used and effective chemotherapeutic agent against cancer. However, nephrotoxicity is one of the most common side effects of cisplatin, and it can proceed to acute kidney injury (AKI). Stu...

    Authors: Fei Deng, Heping Zhang, Wei Zhou, Shijie Ma, Yuwei Kang, Wei Yang, Liangbin Zhao and Wei Qin
    Citation: Journal of Translational Medicine 2023 21:695
  45. A large body of evidence indicates the existence of a complex pathophysiological relationship between cardiovascular diseases and cancer. Mitochondria are crucial organelles whose optimal activity is determine...

    Authors: Carmine Rocca, Teresa Soda, Ernestina Marianna De Francesco, Marco Fiorillo, Francesco Moccia, Giuseppe Viglietto, Tommaso Angelone and Nicola Amodio
    Citation: Journal of Translational Medicine 2023 21:635
  46. Mitochondrial dysfunction is reiteratively involved in the pathogenesis of diverse neurodegenerative diseases. Current in vitro and in vivo approaches support that mitochondrial dysfunction is branded by sever...

    Authors: Felipe A. Bustamante-Barrientos, Noymar Luque-Campos, María Jesús Araya, Eliana Lara-Barba, Javiera de Solminihac, Carolina Pradenas, Luis Molina, Yeimi Herrera-Luna, Yildy Utreras-Mendoza, Roberto Elizondo-Vega, Ana María Vega-Letter and Patricia Luz-Crawford
    Citation: Journal of Translational Medicine 2023 21:613
  47. Fabry disease (FD) is a rare lysosomal storage disorder caused by mutations in the GLA gene, resulting in reduced or lack of α-galactosidase A activity. This results in the accumulation of globotriaosylceramid...

    Authors: Hassan Osman Alhassan Elsaid, Mariell Rivedal, Eleni Skandalou, Einar Svarstad, Camilla Tøndel, Even Birkeland, Øystein Eikrem, Janka Babickova, Hans-Peter Marti and Jessica Furriol
    Citation: Journal of Translational Medicine 2023 21:591
  48. Lower-grade glioma (LGG) is a highly heterogeneous disease that presents challenges in accurately predicting patient prognosis. Mitochondria play a central role in the energy metabolism of eukaryotic cells and...

    Authors: Hu Qin, Aimitaji Abulaiti, Aierpati Maimaiti, Zulihuma Abulaiti, Guofeng Fan, Yirizhati Aili, Wenyu Ji, Zengliang Wang and Yongxin Wang
    Citation: Journal of Translational Medicine 2023 21:588