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Cellular Metabolism Therapy

Section Edited by Salvatore Nesci

Cellular Metabolism Therapy aims to promote the translation of basic research emerging from biochemistry, molecular medicine, physiology and biotechnology into cell metabolism in order to be exploited in clinical applications. 

Studies considered for publication will cover any aspect of translational metabolic research, including (but not limited to): genetic disorders and epigenetic diseases; metabolic derangements causing neurodegeneration; immunometabolism; stroke; cardiovascular diseases; tumours; stem cell bioenergetics; ageing; carbohydrate, lipid, and protein metabolism.


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  1. Right ventricle failure (RVF) is a progressive heart disease that has yet to be fully understood at the molecular level. Elevated M-type pyruvate kinase 2 (PKM2) tetramerization alleviates heart failure, but d...

    Authors: Lizhe Guo, Lu Wang, Gang Qin, Junjie Zhang, Jin Peng, Longyan Li, Xiang Chen, Dandan Wang, Jian Qiu and E. Wang
    Citation: Journal of Translational Medicine 2023 21:888
  2. Despite recent advances in locoregional, systemic, and novel checkpoint inhibitor treatment, hepatocellular carcinoma (HCC) is still associated with poor prognosis. The feasibility of potentially curative live...

    Authors: Dominik T. Koch, Haochen Yu, Iris Beirith, Malte Schirren, Moritz Drefs, Yunfei Liu, Mathilda Knoblauch, Dionysios Koliogiannis, Weiwei Sheng, Enrico N. De Toni, Alexandr V. Bazhin, Bernhard W. Renz, Markus O. Guba, Jens Werner and Matthias Ilmer
    Citation: Journal of Translational Medicine 2023 21:876
  3. Mammalian intestinal epithelium constantly undergoes rapid self-renewal and regeneration sustained by intestinal stem cells (ISCs) within crypts. Inducible nitric oxide synthase (iNOS) is an important regulato...

    Authors: Lingxiao Huang, Zhenni Xu, Xudan Lei, Yujun Huang, Siyu Tu, Lu Xu, Jieying Xia and Dengqun Liu
    Citation: Journal of Translational Medicine 2023 21:852
  4. Activated osteoclasts cause excessive bone resorption, and disrupt bone homeostasis, leading to osteoporosis. The extracellular signal-regulated kinase (ERK) signaling is the classical pathway related to osteo...

    Authors: Tao Yang, Weiwei Chen, Kai Gan, Chaofeng Wang, Xiaoxiao Xie, Yuangang Su, Haoyu Lian, Jiake Xu, Jinmin Zhao and Qian Liu
    Citation: Journal of Translational Medicine 2023 21:839
  5. Doxorubicin (DOX)-induced cardiotoxicity (DIC) is a major impediment to its clinical application. It is indispensable to explore alternative treatment molecules or drugs for mitigating DIC. WGX50, an organic e...

    Authors: Panpan Tai, Xinyu Chen, Guihua Jia, Guanjun Chen, Lian Gong, Yaxin Cheng, Zhuan Li, Heng Wang, Aiyan Chen, Ganghua Zhang, Yuxing Zhu, Mengqing Xiao, Zhanwang Wang, Yunqing Liu, Dongyong Shan, Dong He…
    Citation: Journal of Translational Medicine 2023 21:823
  6. Rett syndrome is a neuropediatric disease occurring due to mutations in MECP2 and characterized by a regression in the neuronal development following a normal postnatal growth, which results in the loss of acquir...

    Authors: Uliana Musokhranova, Cristina Grau, Cristina Vergara, Laura Rodríguez-Pascau, Clara Xiol, Alba A. Castells, Soledad Alcántara, Pilar Rodríguez-Pombo, Pilar Pizcueta, Marc Martinell, Angels García-Cazorla and Alfonso Oyarzábal
    Citation: Journal of Translational Medicine 2023 21:756
  7. Copper (Cu) is an essential element that is involved in a variety of biochemical processes. Both deficiency and accumulation of Cu are associated with various diseases; and a high amount of accumulated Cu in c...

    Authors: Mojtaba Tarin, Maryam Babaie, Hossein Eshghi, Maryam M. Matin and Amir Sh. Saljooghi
    Citation: Journal of Translational Medicine 2023 21:745
  8. Colorectal cancer (CRC) is one of the most common malignant tumors globally, with high morbidity and mortality. Endoplasmic reticulum is a major organelle responsible for protein synthesis, processing, and tra...

    Authors: Hufei Wang, Zhi Li, Yangbao Tao, Suwen Ou, Jinhua Ye, Songlin Ran, Kangjia Luo, Zilong Guan, Jun Xiang, Guoqing Yan, Yang Wang, Tianyi Ma, Shan Yu, Yanni Song and Rui Huang
    Citation: Journal of Translational Medicine 2023 21:713
  9. Extracellular matrix stiffness is emerging as a crucial mechanical cue that drives the progression of various diseases, such as cancer, fibrosis, and inflammation. The matrix stiffness of the nucleus pulposus ...

    Authors: Wencan Ke, Bingjin Wang, Zhiwei Liao, Yu Song, Gaocai Li, Liang Ma, Kun Wang, Shuai Li, Wenbin Hua and Cao Yang
    Citation: Journal of Translational Medicine 2023 21:711
  10. Breast cancer is, despite screening, not always detected early enough and is together with other tumor types known to shed genetic information in circulation. Unlike single-copy nuclear DNA, mitochondrial DNA ...

    Authors: Yanni Li, Kristina Sundquist, Sakshi Vats, Mun-Gwan Hong, Xiao Wang, Yilun Chen, Anna Hedelius, Lao H. Saal, Jan Sundquist and Ashfaque A. Memon
    Citation: Journal of Translational Medicine 2023 21:696
  11. Cisplatin is a widely used and effective chemotherapeutic agent against cancer. However, nephrotoxicity is one of the most common side effects of cisplatin, and it can proceed to acute kidney injury (AKI). Stu...

    Authors: Fei Deng, Heping Zhang, Wei Zhou, Shijie Ma, Yuwei Kang, Wei Yang, Liangbin Zhao and Wei Qin
    Citation: Journal of Translational Medicine 2023 21:695
  12. A large body of evidence indicates the existence of a complex pathophysiological relationship between cardiovascular diseases and cancer. Mitochondria are crucial organelles whose optimal activity is determine...

    Authors: Carmine Rocca, Teresa Soda, Ernestina Marianna De Francesco, Marco Fiorillo, Francesco Moccia, Giuseppe Viglietto, Tommaso Angelone and Nicola Amodio
    Citation: Journal of Translational Medicine 2023 21:635
  13. Mitochondrial dysfunction is reiteratively involved in the pathogenesis of diverse neurodegenerative diseases. Current in vitro and in vivo approaches support that mitochondrial dysfunction is branded by sever...

    Authors: Felipe A. Bustamante-Barrientos, Noymar Luque-Campos, María Jesús Araya, Eliana Lara-Barba, Javiera de Solminihac, Carolina Pradenas, Luis Molina, Yeimi Herrera-Luna, Yildy Utreras-Mendoza, Roberto Elizondo-Vega, Ana María Vega-Letter and Patricia Luz-Crawford
    Citation: Journal of Translational Medicine 2023 21:613
  14. Fabry disease (FD) is a rare lysosomal storage disorder caused by mutations in the GLA gene, resulting in reduced or lack of α-galactosidase A activity. This results in the accumulation of globotriaosylceramid...

    Authors: Hassan Osman Alhassan Elsaid, Mariell Rivedal, Eleni Skandalou, Einar Svarstad, Camilla Tøndel, Even Birkeland, Øystein Eikrem, Janka Babickova, Hans-Peter Marti and Jessica Furriol
    Citation: Journal of Translational Medicine 2023 21:591
  15. Lower-grade glioma (LGG) is a highly heterogeneous disease that presents challenges in accurately predicting patient prognosis. Mitochondria play a central role in the energy metabolism of eukaryotic cells and...

    Authors: Hu Qin, Aimitaji Abulaiti, Aierpati Maimaiti, Zulihuma Abulaiti, Guofeng Fan, Yirizhati Aili, Wenyu Ji, Zengliang Wang and Yongxin Wang
    Citation: Journal of Translational Medicine 2023 21:588
  16. Human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) are seed cells that can be used for alternative treatment of myocardial damage. However, their immaturity limits their clinical applicatio...

    Authors: Huiwen Liu, Li Wang, Hao Xu, Bin Tan, Qin Yi, Hongrong Deng, Yunxia Chen, Bolin He, Jie Tian and Jing Zhu
    Citation: Journal of Translational Medicine 2023 21:581
  17. Benign prostatic hyperplasia (BPH) is a common disease in elderly men, mainly resulted from an imbalance between cell proliferation and death. Glutathione peroxidase 3 (GPX3) was one of the differentially expr...

    Authors: Yan Li, Yongying Zhou, Daoquan Liu, Zhen Wang, Jizhang Qiu, Junchao Zhang, Ping Chen, Guang Zeng, Yuming Guo, Xinghuan Wang, Michael E. DiSanto and Xinhua Zhang
    Citation: Journal of Translational Medicine 2023 21:575
  18. Rheumatoid arthritis (RA) is an autoimmune disease that exhibits a high degree of heterogeneity, marked by unpredictable disease flares and significant variations in the response to available treatments. The l...

    Authors: Qi Wang, Qi-Chao Gao, Qi-Chuan Wang, Li Wu, Qi Yu and Pei-Feng He
    Citation: Journal of Translational Medicine 2023 21:561
  19. Peripheral nerve injury can cause neuroinflammation and neuromodulation that lead to mitochondrial dysfunction and neuronal apoptosis in the dorsal root ganglion (DRG) and spinal cord, contributing to neuropat...

    Authors: Yaseen Awad-Igbaria, Nadine Ferreira, Ali Keadan, Reem Sakas, Doron Edelman, Alon Shamir, Jean Francous-Soustiel and Eilam Palzur
    Citation: Journal of Translational Medicine 2023 21:545
  20. Glioblastoma (GBM) is a brain tumor with the highest level of malignancy and the worst prognosis in the central nervous system. Mitochondrial metabolism plays a vital role in the occurrence and development of ...

    Authors: Tongxuan Guo, Changyong Wu, Lingni Zhou, Junhao Zhang, Wanzhou Wang, Yang Shen, Ludong Zhang, Mingshan Niu, Xu Zhang, Rutong Yu and Xuejiao Liu
    Citation: Journal of Translational Medicine 2023 21:532
  21. Colorectal cancer (CRC) can be classified into four molecular subtypes (CMS) among which CMS1 is associated with the best prognosis, while CMS4, the mesenchymal subtype, has the worst outcome. Although mitocho...

    Authors: Jean Bastin, Marine Sroussi, Ivan Nemazanyy, Pierre Laurent-Puig, Sophie Mouillet-Richard and Fatima Djouadi
    Citation: Journal of Translational Medicine 2023 21:522
  22. Mitochondria are the only organelles regulated by two genomes. The coordinated translation of nuclear DNA (nDNA) and mitochondrial DNA (mtDNA), which together co-encode the subunits of the oxidative phosphoryl...

    Authors: Jiaoyan Ma, Liankun Sun, Weinan Gao, Yang Li and Delu Dong
    Citation: Journal of Translational Medicine 2023 21:512
  23. Metabolic dysfunction-associated fatty liver disease (MAFLD) is among the most widespread metabolic disease globally, and its associated complications including insulin resistance and diabetes have become thre...

    Authors: Youwei Zheng, Shiting Wang, Jialiang Wu and Yong Wang
    Citation: Journal of Translational Medicine 2023 21:510
  24. Mitochondria play important roles in maintaining cellular homeostasis and skeletal muscle health, and damage to mitochondria can lead to a series of pathophysiological changes. Mitochondrial dysfunction can le...

    Authors: Xin Chen, Yanan Ji, Ruiqi Liu, Xucheng Zhu, Kexin Wang, Xiaoming Yang, Boya Liu, Zihui Gao, Yan Huang, Yuntian Shen, Hua Liu and Hualin Sun
    Citation: Journal of Translational Medicine 2023 21:503
  25. Diabetes is associated with an increased risk of cognitive decline and dementia. These diseases are linked with mitochondrial dysfunction, most likely as a consequence of excessive formation of mitochondria-as...

    Authors: Yanmin Chang, Cailin Wang, Jiahui Zhu, Siyi Zheng, Shangqi Sun, Yanqing Wu, Xingjun Jiang, Lulu Li, Rong Ma and Gang Li
    Citation: Journal of Translational Medicine 2023 21:494
  26. Lipid metabolism plays an important role in liver regeneration, but its regulation still requires further research. In this study, lipid metabolites involved in mouse liver regeneration at different time point...

    Authors: Xi Zhou, Guobin Huang, Lu Wang, Yuanyuan Zhao, Junbo Li, Dong Chen, Lai Wei, Zhishui Chen and Bo Yang
    Citation: Journal of Translational Medicine 2023 21:487
  27. Sepsis-associated encephalopathy (SAE) is characterized by diffuse brain dysfunction, long-term cognitive impairment, and increased morbidity and mortality. The current treatment for SAE is mainly symptomatic;...

    Authors: Yuqiang Liu, Han Yang, Nanbo Luo, Yifei Fu, Fang Qiu, Zhenglong Pan, Xiongjuan Li, Wenling Jian, Xinping Yang, Qingsheng Xue, Yan Luo, Buwei Yu and Zhiheng Liu
    Citation: Journal of Translational Medicine 2023 21:486
  28. Bone regeneration therapy is clinically important, and targeted regulation of endoplasmic reticulum (ER) stress is important in regenerative medicine. The processing of proteins in the ER controls cell fate. T...

    Authors: Tingyu Wu, Yaping Jiang, Weipeng Shi, Yingzhen Wang and Tao Li
    Citation: Journal of Translational Medicine 2023 21:480
  29. Interleukin-1 receptor antagonist (IL-1RA), a member of the IL-1 family, has diverse roles in cancer development. However, the role of IL-1RA in oral squamous cell carcinoma (OSCC), in particular the underlyin...

    Authors: Shyng-Shiou F. Yuan, Yun-Ming Wang, Leong-Perng Chan, Amos C. Hung, Hieu D. H. Nguyen, Yuk-Kwan Chen, Stephen Chu‐Sung Hu, Steven Lo and Yen-Yun Wang
    Citation: Journal of Translational Medicine 2023 21:473
  30. Cell pyroptosis has a strong proinflammatory effect, but it is unclear whether pyroptosis of liver macrophages exacerbates liver tissue damage during liver ischemia‒reperfusion (I/R) injury. Maresin1 (MaR1) ha...

    Authors: Tong Li, Houshuai Zeng, Wenjing Xian, Hongxing Cai, Jianbo Zhang, Shiji Zhou, Yingxue Yang, Min Luo and Peng Zhu
    Citation: Journal of Translational Medicine 2023 21:472
  31. Pulmonary arterial hypertension (PAH) is a highly prevalent cardiopulmonary disorder characterized by vascular remodeling and increased resistance in pulmonary artery. Mitochondrial coiled–coil–helix–coiled–co...

    Authors: Yu Wang, Zhenyu Zeng, Zhaoxiang Zeng, Guojun Chu and Xinghua Shan
    Citation: Journal of Translational Medicine 2023 21:464
  32. Alzheimer's disease (AD) is the most common neurodegenerative disease. Mitochondrial dysfunction and immune responses are important factors in the pathogenesis of AD, but their crosstalk in AD has not been stu...

    Authors: Yaodan Zhang, Yuyang Miao, Jin Tan, Fanglian Chen, Ping Lei and Qiang Zhang
    Citation: Journal of Translational Medicine 2023 21:458
  33. Osteoarthritis (OA), in which macrophage-driven synovitis is considered closely related to cartilage destruction and could occur at any stage, is an inflammatory arthritis. However, there are no effective targ...

    Authors: Zhen Zhang, Shujun Xie, Jin Qian, Fengqiang Gao, Wenjian Jin, Lingqiao Wang, Lili Yan, Hao Chen, Wangxiang Yao, Maoqiang Li, Xuepeng Wang and Liulong Zhu
    Citation: Journal of Translational Medicine 2023 21:452
  34. Endothelial cells (ECs) angiogenesis is the process of sprouting new vessels from the existing ones, playing critical roles in physiological and pathological processes such as wound healing, placentation, isch...

    Authors: Zhen Luo, Jianbo Yao, Zhe Wang and Jianxiong Xu
    Citation: Journal of Translational Medicine 2023 21:441
  35. Inflammation and immune dysfunction with classically activated macrophages(M1) infiltration are important mechanisms in the progression of atherosclerosis (AS). Dynamin-related protein 1 (DRP1)-dependent mitoc...

    Authors: Ze-da-zhong Su, Chun-qiu Li, Hua-wei Wang, Min-ming Zheng and Qing-wei Chen
    Citation: Journal of Translational Medicine 2023 21:427
  36. Acute-on-chronic liver failure (ACLF) is a severe syndrome with high short-term mortality, but the pathophysiology still remains largely unknown. Immune dysregulation and metabolic disorders contribute to the ...

    Authors: Bo Peng, Hao Li, Kai Liu, Pengpeng Zhang, Quan Zhuang, Junhui Li, Min Yang, Ke Cheng and Yingzi Ming
    Citation: Journal of Translational Medicine 2023 21:419
  37. The family with sequence similarity 20-member C (FAM20C) kinase, a Golgi casein kinase, which is responsible for phosphorylating the majority of the extracellular phosphoproteins within S-x-E/pS motifs, and is...

    Authors: Xinpeng Liu, Lili Jiang, Wenxuan Zhang, Jiahui Zhang, Xinrui Luan, Yuanbo Zhan, Tuo Wang, Junlong Da, Lixue Liu, Shujian Zhang, Yuyao Guo, Kai Zhang, Zhiping Wang, Nan Miao, Xiaohua Xie, Peihong Liu…
    Citation: Journal of Translational Medicine 2023 21:417
  38. Nucleus pulposus cell (NPC) death and progressive reduction play important roles in intervertebral disc degeneration (IVDD). As part of a damage-associated molecular pattern, mitochondrial DNA (mtDNA) can be r...

    Authors: Peng Lu, Huayong Zheng, Hao Meng, Chuan Liu, Lianhong Duan, Jianzheng Zhang, Zhicheng Zhang, Jie Gao, Yang Zhang and Tiansheng Sun
    Citation: Journal of Translational Medicine 2023 21:389
  39. Cardiovascular disease (CVD) is the leading cause of noncommunicable disease-related death worldwide, and effective therapeutic strategies against CVD are urgently needed. Mitochondria dysfunction involves in ...

    Authors: Mingchu Sun, Wenhua Jiang, Nan Mu, Zihui Zhang, Lu Yu and Heng Ma
    Citation: Journal of Translational Medicine 2023 21:347
  40. Malignant melanoma is one of the most common tumours and has the highest mortality rate of all types of skin cancers worldwide. Traditional and novel therapeutic approaches, including surgery, targeted therapy...

    Authors: Fei Du, Lu-han Yang, Jiao Liu, Jian Wang, Lianpeng Fan, Suwit Duangmano, Hao Liu, Minghua Liu, Jun Wang, Xiaolin Zhong, Zhuo Zhang and Fang Wang
    Citation: Journal of Translational Medicine 2023 21:345
  41. Interleukin-17A (IL-17A), a proinflammatory cytokine primarily secreted by Th17 cells, γδT cells and natural killer T (NKT) cells, performs essential roles in the microenvironment of certain inflammation-relat...

    Authors: Wen-Qing Feng, Yu-Chen Zhang, Zhuo-Qing Xu, Su-Yue Yu, Jian-ting Huo, Abudumaimaitijiang Tuersun, Min-Hua Zheng, Jing-Kun Zhao, Ya-Ping Zong and Ai-Guo Lu
    Citation: Journal of Translational Medicine 2023 21:335
  42. People with mitochondrial disease (MtD) are susceptible to metabolic decompensation and neurological symptom progression in response to an infection. Increasing evidence suggests that mitochondrial dysfunction...

    Authors: Emily B. Warren, Eliza M. Gordon-Lipkin, Foo Cheung, Jinguo Chen, Amrita Mukherjee, Richard Apps, John S. Tsang, Jillian Jetmore, Melissa L. Schlein, Shannon Kruk, Yuanjiu Lei, A. Phillip West and Peter J. McGuire
    Citation: Journal of Translational Medicine 2023 21:331
  43. Oral squamous cell carcinoma (OSCC) is one of the most prevalent and fatal oral cancers. Mitochondria-targeting therapies represent promising strategies against various cancers, but their applications in treat...

    Authors: Yafei Zhang, Bingqian Yang, Chengwei Tu, Yifan Ping, Shuhong Chen, Tong Wu, Zheyu Zhao, Yixin Mao, Zhan Yang, Zelin Cao, Jianmin Li, Kate Huang, Xi Ding, Gang Wu, Peng Zou, Zhennan Deng…
    Citation: Journal of Translational Medicine 2023 21:328
  44. Cervical cancer remains one of the most prevalent cancers worldwide. Accumulating evidence suggests that specificity protein 1 (Sp1) plays a pivotal role in tumour progression. The underlying role and mechanis...

    Authors: Xu Xu, Xiaona Wang, Qihui Chen, Aman Zheng, Donglu Li, Ziqi Meng, Xinran Li, Hanchen Cai, Wangzhi Li, Shiyuan Huang and Fan Wang
    Citation: Journal of Translational Medicine 2023 21:307
  45. Available literature documents that ischemic stroke can disrupt the morphology and function of mitochondria and that the latter in other disease models can be preserved by neuropilin-1 (NRP-1) via oxidative st...

    Authors: Ting Guo, Manli Chen, Ji Liu, Zengyu Wei, Jinjin Yuan, Wenwen Wu, Zhiyun Wu, Yongxing Lai, Zijun Zhao, Hongbin Chen and Nan Liu
    Citation: Journal of Translational Medicine 2023 21:297
  46. Immune-mediated rejection was the major cause of graft dysfunction. Although the advances in immunosuppressive agents have markedly reduced the incidence of T-cell-mediated rejection after transplantation. How...

    Authors: Yannan Zhang, Jiannan He, Zhe Yang, Haofeng Zheng, Haoxiang Deng, Zihuan Luo, Qipeng Sun and Qiquan Sun
    Citation: Journal of Translational Medicine 2023 21:295
  47. Recent evidence has shown significant roles of mitochondria-derived vesicles (MDVs) in mitochondrial quality control (MQC) system. Under mild stress condition, MDVs are formed to carry the malfunctioned mitoch...

    Authors: Sakdithep Chaiyarit and Visith Thongboonkerd
    Citation: Journal of Translational Medicine 2023 21:294

    The Correction to this article has been published in Journal of Translational Medicine 2023 21:460

  48. The Hypoxia inducible gene domain family member 2A (HIGD2A) protein is indispensable for the assembly of the mitochondrial respiratory supercomplex, which has been implicated in cell proliferation and cell sur...

    Authors: Kuiyuan Huang, Ziying Liu, Zhanglian Xie, Xiaoran Li, Haixing Zhang, Yu Chen, Yiran Wang, Zimo Lin, Chuanjiang Li, Hongyan Liu and Xiaoyong Zhang
    Citation: Journal of Translational Medicine 2023 21:253
  49. Lung adenocarcinoma (LUAD) is the most prevalent subtype of lung cancer with high morbidity and mortality rates. Due to the heterogeneity of LUAD, its characteristics remain poorly understood. Exploring the cl...

    Authors: Yichun Xu, Yong Yang, Yichao Wang, Jun Su, Tianlong Chan, Jiajing Zhou, Yi Gong, Ke Wang, Yifeng Gu, Congmeng Zhang, Guanjin Wu, Ling Bi, Xiong Qin and Junsong Han
    Citation: Journal of Translational Medicine 2023 21:250

    The Correction to this article has been published in Journal of Translational Medicine 2023 21:268

  50. Substantial evidence suggests that immunoproteasome is implicated in the various neurological diseases such as stroke, multiple sclerosis and neurodegenerative diseases. However, whether the immunoproteasome i...

    Authors: Xingyong Chen, Yanguang Mao, Yueting Guo, Dongyun Xiao, Zejing Lin, Yiyi Huang, Ying Chun Liu, Xu Zhang and Yinzhou Wang
    Citation: Journal of Translational Medicine 2023 21:226