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Immune RadioBiology

Section edited by Claire Vanpouille-Box

The Iummne RadioBiology section is interested in innovative research that investigate the crosstalk between ionizing radiations (IR), the tumor microenvironment (TME) and host immunity. 

Studies considered for publication include (but not limited to) those investigating the mechanisms of radiation-induced anti-tumor immune responses, the immune-stimulatory and immuno-suppressive properties of ionizing radiation from all sources (X-rays, FLASH-RT, protons, carbon ion and radionuclides), biomarkers predictive of immune response, immune escape mechanisms elicited by IR and radioresistance. Importantly, the section welcomes translational and clinical studies assessing the combination of IR with immunotherapies (IT) with an emphasis on clinical response and outcome.

  1. This paper intends to propose a method of using TransResSEUnet2.5D network for accurate automatic segmentation of the Gross Target Volume (GTV) in Radiotherapy for lung cancer.

    Authors: Hui Xie, Zijie Chen, Jincheng Deng, Jianfang Zhang, Hanping Duan and Qing Li
    Citation: Journal of Translational Medicine 2022 20:524
  2. Radioresistance is a major cause of treatment failure in esophageal squamous cell carcinoma (ESCC) radiotherapy, and the underlying mechanisms of radioresistance are still unclear. Irradiation (IR) stimulates ...

    Authors: Xingyu Du, Xueyuan Zhang, Jing Dong, Naiyi Zou, Dong Guo, Weinan Yao, Xiaobin Wang, Shuguang Li, Chunyang Song, Ke Yan, Wenbin Shen and Shuchai Zhu
    Citation: Journal of Translational Medicine 2022 20:507
  3. Epithelial-to-mesenchymal transition (EMT) is a critical event contributing to more aggressive phenotypes in cancer cells. EMT is frequently activated in radiation-targeted cells during the course of radiother...

    Authors: Xiao-Ya Sun, Hao-Zheng Li, Da-Fei Xie, Shan-Shan Gao, Xin Huang, Hua Guan, Chen-Jun Bai and Ping-Kun Zhou
    Citation: Journal of Translational Medicine 2022 20:456
  4. Radiotherapy is the primary therapeutic option for glioblastoma. Some studies proved that radiotherapy increased the release of exosomes from cells. The mechanism by which these exosomes modify the phenotype o...

    Authors: Chunzhi Zhang, Yuan Zhou, Ya Gao, Ze Zhu, Xianliang Zeng, Weizi Liang, Songwei Sun, Xiuli Chen and Hu Wang
    Citation: Journal of Translational Medicine 2022 20:388
  5. The resistance to radiotherapy remains a major obstacle that limits the efficacy of radiotherapy in non-small cell lung cancer (NSCLC). This study aims to illustrate the molecular mechanism underlying the role...

    Authors: Li-Ming Xu, Ya-Jing Yuan, Hao Yu, Shuai Wang and Ping Wang
    Citation: Journal of Translational Medicine 2022 20:350
  6. The overall survival (OS) of stage I operable lung cancer is relatively low, and not all patients can benefit from adjuvant chemotherapy. This study aimed to develop and validate a radiomic signature (RS) for ...

    Authors: Wei Nie, Guangyu Tao, Zhenghai Lu, Jie Qian, Yaqiong Ge, Shuyuan Wang, Xueyan Zhang, Hua Zhong and Hong Yu
    Citation: Journal of Translational Medicine 2022 20:339
  7. Nasopharyngeal carcinoma (NPC) is a malignant tumor of epithelial origin in head and neck with high incidence rate in Southern China. C2orf40 has been identified as a tumor suppressor gene in many cancers. How...

    Authors: Zuozhong Xie, Wei Li, Jingang Ai, Jun Xie and Xiaowei Zhang
    Citation: Journal of Translational Medicine 2022 20:264
  8. We established a radiogenomic model to predict pathological complete response (pCR) in triple-negative breast cancer (TNBC) and explored the association between high-frequency mutations and drug resistance.

    Authors: Ying Zhang, Chao You, Yuchen Pei, Fan Yang, Daqiang Li, Yi-zhou Jiang and Zhimin Shao
    Citation: Journal of Translational Medicine 2022 20:256
  9. Nicotinamide (NAM, a variant of vitamin B3) has recently been shown to accelerate the activation of human CD4+ and CD8+ T cells exposed to repeated CD3/CD28 agonism in vitro. Here, we demonstrate that T cells inf...

    Authors: Yang Hu, Norma Bloy, Olivier Elemento and Aitziber Buqué
    Citation: Journal of Translational Medicine 2022 20:251
  10. Urinary extracellular vesicles (EVs) are a source of biomarkers with broad potential applications across clinical research, including monitoring radiation exposure. A key limitation to their implementation is ...

    Authors: Charles P. Hinzman, Meth Jayatilake, Sunil Bansal, Brian L. Fish, Yaoxiang Li, Yubo Zhang, Shivani Bansal, Michael Girgis, Anton Iliuk, Xiao Xu, Jose A. Fernandez, John H. Griffin, Elizabeth A. Ballew, Keith Unger, Marjan Boerma, Meetha Medhora…
    Citation: Journal of Translational Medicine 2022 20:199
  11. Radiotherapy is among the routine treatment options for malignant tumors. And it damages DNA and other cellular organelles in target cells by using ionizing radiation produced by various rays, killing the cell...

    Authors: Huihui Sun, Rui Sun, Xing Song, Wendong Gu and Yingjie Shao
    Citation: Journal of Translational Medicine 2022 20:189
  12. Medical applications of ionising radiation and associated radiation protection research often encounter long delays and inconsistent implementation when translated into clinical practice. A coordinated effort ...

    Authors: Sophie Bockhold, Shane J. Foley, Louise A. Rainford, Riccardo Corridori, Annika Eberstein, Christoph Hoeschen, Mark W. Konijnenberg, Susan Molyneux-Hodgson, Graciano Paulo, Joana Santos and Jonathan P. McNulty
    Citation: Journal of Translational Medicine 2022 20:137
  13. Histone deacetylases (HDACs) have been identified to be implicated in the carcinogenesis and cancer progression. The present study was performed to probe into the effect of HDAC4 on radioresistance of esophage...

    Authors: Zhonghua Lu, Yifei Yun, Yutong Zhang, Yao Ou and Meihua Wang
    Citation: Journal of Translational Medicine 2022 20:101
  14. Epidermal growth factor receptor (EGFR)-mutant lung cancers have a high risk of developing brain metastases (BM). Whole brain radiotherapy (WBRT), local radiotherapy, and WBRT + Boost are frequently used for trea...

    Authors: Guangchuan Deng, Yingyun Zhang, Jiaojiao Ke, Qi Wang, Hongyue Qin, Jianbin Li and Zhenxiang Li
    Citation: Journal of Translational Medicine 2021 19:486

    The Correction to this article has been published in Journal of Translational Medicine 2021 19:503

  15. Most head and neck cancer (HNC) patients receive radiotherapy (RT) and develop toxicities. This genome-wide association study (GWAS) was designed to identify single nucleotide polymorphisms (SNPs) associated w...

    Authors: Elnaz Naderi, Anne Petra Gerarda Crijns, Roel Johannes Henricus Marinus Steenbakkers, Johanna Geertruida Maria van den Hoek, Hendrika Marike Boezen, Behrooz Ziad Alizadeh and Johannes Albertus Langendijk
    Citation: Journal of Translational Medicine 2021 19:481
  16. Radiotherapy (RT) still represents a mainstay of treatment in clinical oncology. Traditionally, the effectiveness of radiotherapy has been attributed to the killing potential of ionizing radiation (IR) over ma...

    Authors: Turid Hellevik, Rodrigo Berzaghi, Kristin Lode, Ashraful Islam and Inigo Martinez-Zubiaurre
    Citation: Journal of Translational Medicine 2021 19:437
  17. Compared to the other members of human epidermal growth factor family receptors (HER), the role of HER3 has not been well defined in laryngeal cancer. The predictive and prognostic role of HER3 has been the fo...

    Authors: Giovanni Almadori, Antonella Coli, Eugenio De Corso, Dario Antonio Mele, Stefano Settimi, Giovanni Di Cintio, Francesca Brigato, Domenico Scannone, Thomas E. Carey, Gaetano Paludetti, Libero Lauriola and Franco Oreste Ranelletti
    Citation: Journal of Translational Medicine 2021 19:408
  18. Solute carrier family 7 member 11(SLC7A11) is a component of cysteine/glutamate transporter, which plays a key role in tumor growth; however, its underlying effect on radiosensitivity in esophageal squamous ce...

    Authors: Lei Feng, Kaikai Zhao, Liangchao Sun, Xiaoyang Yin, Junpeng Zhang, Conghe Liu and Baosheng Li
    Citation: Journal of Translational Medicine 2021 19:367
  19. Although reports implicate radioresistance as an important obstacle for the management of breast cancer, its molecular mechanism is elusive. Herein, we found that high HDGF levels are expressed significantly i...

    Authors: Lingyun Qiu, Yan Ma, Xiaohua Chen, Liheng Zhou, Haibo Zhang, Guansheng Zhong, Lei Zhang and Jianming Tang
    Citation: Journal of Translational Medicine 2021 19:344
  20. Radiotherapy is the mainstay treatment for lung adenocarcinoma, yet remains highly susceptible to resistance. Fe3O4 magnetic nanoparticles (MNPs) possess the ability to induce biological therapeutic effects. Here...

    Authors: Shuzhen Chen, Fushi Han, Dongdong Huang, Jinqian Meng, Jiapeng Chu, Meng Wang and Peijun Wang
    Citation: Journal of Translational Medicine 2021 19:337
  21. The glutathione S-transferase P1(GSTP1) is an isoenzyme in the glutathione-S transferases (GSTs) enzyme system, which is the most abundant GSTs expressed in adult lungs. Recent research shows that GSTP1 is clo...

    Authors: Xiao Lei, Lehui Du, Wei Yu, Yao Wang, Na Ma and Baolin Qu
    Citation: Journal of Translational Medicine 2021 19:297