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Immune RadioBiology

Section edited by Claire Vanpouille-Box

The Iummne RadioBiology section is interested in innovative research that investigate the crosstalk between ionizing radiations (IR), the tumor microenvironment (TME) and host immunity. 

Studies considered for publication include (but not limited to) those investigating the mechanisms of radiation-induced anti-tumor immune responses, the immune-stimulatory and immuno-suppressive properties of ionizing radiation from all sources (X-rays, FLASH-RT, protons, carbon ion and radionuclides), biomarkers predictive of immune response, immune escape mechanisms elicited by IR and radioresistance. Importantly, the section welcomes translational and clinical studies assessing the combination of IR with immunotherapies (IT) with an emphasis on clinical response and outcome.

  1. The recurrence of hepatocellular carcinoma (HCC) after radiofrequency ablation (RFA) remains a major clinical problem. Cells that survive the sublethal heat stress that is induced by incomplete RFA are the mai...

    Authors: Chao Peng, Xi Li, Feng Ao, Ting Li, Jingpei Guo, Junfeng Liu, Xiaoting Zhang, Jinyan Gu, Junjie Mao and Bin Zhou
    Citation: Journal of Translational Medicine 2023 21:218
  2. Apurinic/apyrimidinic endonuclease 1 (APE1) imparts radio-resistance by repairing isolated lesions via the base excision repair (BER) pathway, but whether and how it is involved in the formation and/or repair ...

    Authors: Qin Zhang, Lujie Yang, Han Gao, Xunjie Kuang, He Xiao, Chen Yang, Yi Cheng, Lei Zhang, Xin Guo, Yong Zhong and Mengxia Li
    Citation: Journal of Translational Medicine 2023 21:183
  3. Radiotherapy resistance is the main cause of low tumor regression for locally advanced rectum adenocarcinoma (READ). The biomarkers correlated to radiotherapy sensitivity and potential molecular mechanisms hav...

    Authors: Pengfei Zhao, Hongchao Zhen, Hong Zhao, Yongjie Huang and Bangwei Cao
    Citation: Journal of Translational Medicine 2023 21:176
  4. Alpha-emitter radiopharmaceutical therapy (αRPT) has shown promising outcomes in metastatic disease. However, the short range of the alpha particles necessitates dosimetry on a near-cellular spatial scale. Cur...

    Authors: Remco Bastiaannet, Ioanna Liatsou, Robert F Hobbs and George Sgouros
    Citation: Journal of Translational Medicine 2023 21:144
  5. Radiotherapy resistance is the main cause of treatment failure in nasopharyngeal carcinoma (NPC), which leads to poor prognosis. It is urgent to elucidate the molecular mechanisms underlying radiotherapy resis...

    Authors: Enni Chen, Jiajia Huang, Miao Chen, Jiawei Wu, Puyun Ouyang, Xiaonan Wang, Dingbo Shi, Zhiqiao Liu, Wancui Zhu, Haohui Sun, Shanshan Yang, Baoyu Zhang, Wuguo Deng, Huijuan Qiu and Fangyun Xie
    Citation: Journal of Translational Medicine 2023 21:134
  6. Preclinical evidence from us and others demonstrates that the anticancer effects of cyclin-dependent kinase 4/6 (CDK4/6) inhibitors can be enhanced with focal radiation therapy (RT), but only when RT is delive...

    Authors: Vanessa Klapp, Aitziber Buqué, Norma Bloy, Ai Sato, Takahiro Yamazaki, Xi Kathy Zhou, Silvia C. Formenti, Lorenzo Galluzzi and Giulia Petroni
    Citation: Journal of Translational Medicine 2023 21:110
  7. Nasopharyngeal carcinoma (NPC) is a kind of epithelial carcinoma that is common in East and Southeast Asia. Distant metastasis after radiotherapy remains the main cause of treatment failure and preradiotherapy...

    Authors: Xiaotian Xu, Fangze Wei, Lin Xiao, Runye Wu, Baojun Wei, Shengkai Huang, Junlin Yi and Wei Cui
    Citation: Journal of Translational Medicine 2023 21:64
  8. Radiotherapy (RT) is the standard treatment for nasopharyngeal carcinoma (NPC). However, due to individual differences in radiosensitivity, biomarkers are needed to tailored radiotherapy to cancer patients. Ho...

    Authors: Lu-Lu Yu, Bi-Wen Hu, Han-Xue Huang, Bing Yu, Qi Xiao, Qiao-Li Lv, Chen-Hui Luo, Cheng-Xian Guo, Jin-Gao Li, Xiao-Xue Xie and Ji-Ye Yin
    Citation: Journal of Translational Medicine 2023 21:11
  9. The most common form of treatment for non-metastatic lung cancer is surgery-based combination therapy, which may also include adjuvant radiotherapy or chemotherapy. Second primary malignancies (SPMs) are uncom...

    Authors: Bolun Zhou, Ruochuan Zang, Peng Song, Moyan Zhang, Fenglong Bie, Guangyu Bai, Yuan Li, Qilin Huai, Yuning Han and Shugeng Gao
    Citation: Journal of Translational Medicine 2023 21:10
  10. Sterile alpha motif domain and histidine-aspartate domain-containing protein 1 (SAMHD1) is a DNA end resection factor, which is involved in DNA damage repair and innate immunity. However, the role of SAMHD1 in...

    Authors: Yangyi Li, Yuke Gao, Xueping Jiang, Yajie Cheng, Jianguo Zhang, Liexi Xu, Xinyu Liu, Zhengrong Huang, Conghua Xie and Yan Gong
    Citation: Journal of Translational Medicine 2022 20:628
  11. Radiotherapy is one of the main treatments for esophageal squamous cell carcinoma (ESCC), but its efficacy is limited by radioresistance. MicroRNAs play a crucial role in posttranscriptional regulation, which ...

    Authors: Xiaobo Shi, Xiaoxiao Liu, Shan Huang, Yu Hao, Shupei Pan, Yue Ke, Wei Guo, Yuchen Wang and Hongbing Ma
    Citation: Journal of Translational Medicine 2022 20:626
  12. Radiation-induced lung injury (RILI) often occurs during clinical chest radiotherapy and acute irradiation from accidental nuclear leakage. This study explored the role of monophosphoryl lipid A (MPLA) in RILI.

    Authors: Xingdong Guo, Lehui Du, Na Ma, Pei Zhang, Yuan Wang, Yanan Han, Xiang Huang, Qian Zhang, Xin Tan, Xiao Lei and Baolin Qu
    Citation: Journal of Translational Medicine 2022 20:597
  13. In the management of head and neck cancer (HNC) patients, local recurrence is a common cause of treatment failure. Only a few patients with recurrent HNC (rHNC) are eligible for salvage surgery and the majorit...

    Authors: Yue Li, Yuliang Jiang, Bin Qiu, Haitao Sun and Junjie Wang
    Citation: Journal of Translational Medicine 2022 20:566
  14. This paper intends to propose a method of using TransResSEUnet2.5D network for accurate automatic segmentation of the Gross Target Volume (GTV) in Radiotherapy for lung cancer.

    Authors: Hui Xie, Zijie Chen, Jincheng Deng, Jianfang Zhang, Hanping Duan and Qing Li
    Citation: Journal of Translational Medicine 2022 20:524
  15. Radioresistance is a major cause of treatment failure in esophageal squamous cell carcinoma (ESCC) radiotherapy, and the underlying mechanisms of radioresistance are still unclear. Irradiation (IR) stimulates ...

    Authors: Xingyu Du, Xueyuan Zhang, Jing Dong, Naiyi Zou, Dong Guo, Weinan Yao, Xiaobin Wang, Shuguang Li, Chunyang Song, Ke Yan, Wenbin Shen and Shuchai Zhu
    Citation: Journal of Translational Medicine 2022 20:507
  16. Epithelial-to-mesenchymal transition (EMT) is a critical event contributing to more aggressive phenotypes in cancer cells. EMT is frequently activated in radiation-targeted cells during the course of radiother...

    Authors: Xiao-Ya Sun, Hao-Zheng Li, Da-Fei Xie, Shan-Shan Gao, Xin Huang, Hua Guan, Chen-Jun Bai and Ping-Kun Zhou
    Citation: Journal of Translational Medicine 2022 20:456
  17. Radiotherapy is the primary therapeutic option for glioblastoma. Some studies proved that radiotherapy increased the release of exosomes from cells. The mechanism by which these exosomes modify the phenotype o...

    Authors: Chunzhi Zhang, Yuan Zhou, Ya Gao, Ze Zhu, Xianliang Zeng, Weizi Liang, Songwei Sun, Xiuli Chen and Hu Wang
    Citation: Journal of Translational Medicine 2022 20:388
  18. The resistance to radiotherapy remains a major obstacle that limits the efficacy of radiotherapy in non-small cell lung cancer (NSCLC). This study aims to illustrate the molecular mechanism underlying the role...

    Authors: Li-Ming Xu, Ya-Jing Yuan, Hao Yu, Shuai Wang and Ping Wang
    Citation: Journal of Translational Medicine 2022 20:350
  19. The overall survival (OS) of stage I operable lung cancer is relatively low, and not all patients can benefit from adjuvant chemotherapy. This study aimed to develop and validate a radiomic signature (RS) for ...

    Authors: Wei Nie, Guangyu Tao, Zhenghai Lu, Jie Qian, Yaqiong Ge, Shuyuan Wang, Xueyan Zhang, Hua Zhong and Hong Yu
    Citation: Journal of Translational Medicine 2022 20:339
  20. Nasopharyngeal carcinoma (NPC) is a malignant tumor of epithelial origin in head and neck with high incidence rate in Southern China. C2orf40 has been identified as a tumor suppressor gene in many cancers. How...

    Authors: Zuozhong Xie, Wei Li, Jingang Ai, Jun Xie and Xiaowei Zhang
    Citation: Journal of Translational Medicine 2022 20:264
  21. We established a radiogenomic model to predict pathological complete response (pCR) in triple-negative breast cancer (TNBC) and explored the association between high-frequency mutations and drug resistance.

    Authors: Ying Zhang, Chao You, Yuchen Pei, Fan Yang, Daqiang Li, Yi-zhou Jiang and Zhimin Shao
    Citation: Journal of Translational Medicine 2022 20:256
  22. Nicotinamide (NAM, a variant of vitamin B3) has recently been shown to accelerate the activation of human CD4+ and CD8+ T cells exposed to repeated CD3/CD28 agonism in vitro. Here, we demonstrate that T cells inf...

    Authors: Yang Hu, Norma Bloy, Olivier Elemento and Aitziber Buqué
    Citation: Journal of Translational Medicine 2022 20:251
  23. Urinary extracellular vesicles (EVs) are a source of biomarkers with broad potential applications across clinical research, including monitoring radiation exposure. A key limitation to their implementation is ...

    Authors: Charles P. Hinzman, Meth Jayatilake, Sunil Bansal, Brian L. Fish, Yaoxiang Li, Yubo Zhang, Shivani Bansal, Michael Girgis, Anton Iliuk, Xiao Xu, Jose A. Fernandez, John H. Griffin, Elizabeth A. Ballew, Keith Unger, Marjan Boerma, Meetha Medhora…
    Citation: Journal of Translational Medicine 2022 20:199
  24. Radiotherapy is among the routine treatment options for malignant tumors. And it damages DNA and other cellular organelles in target cells by using ionizing radiation produced by various rays, killing the cell...

    Authors: Huihui Sun, Rui Sun, Xing Song, Wendong Gu and Yingjie Shao
    Citation: Journal of Translational Medicine 2022 20:189
  25. Medical applications of ionising radiation and associated radiation protection research often encounter long delays and inconsistent implementation when translated into clinical practice. A coordinated effort ...

    Authors: Sophie Bockhold, Shane J. Foley, Louise A. Rainford, Riccardo Corridori, Annika Eberstein, Christoph Hoeschen, Mark W. Konijnenberg, Susan Molyneux-Hodgson, Graciano Paulo, Joana Santos and Jonathan P. McNulty
    Citation: Journal of Translational Medicine 2022 20:137
  26. Histone deacetylases (HDACs) have been identified to be implicated in the carcinogenesis and cancer progression. The present study was performed to probe into the effect of HDAC4 on radioresistance of esophage...

    Authors: Zhonghua Lu, Yifei Yun, Yutong Zhang, Yao Ou and Meihua Wang
    Citation: Journal of Translational Medicine 2022 20:101
  27. Epidermal growth factor receptor (EGFR)-mutant lung cancers have a high risk of developing brain metastases (BM). Whole brain radiotherapy (WBRT), local radiotherapy, and WBRT + Boost are frequently used for trea...

    Authors: Guangchuan Deng, Yingyun Zhang, Jiaojiao Ke, Qi Wang, Hongyue Qin, Jianbin Li and Zhenxiang Li
    Citation: Journal of Translational Medicine 2021 19:486

    The Correction to this article has been published in Journal of Translational Medicine 2021 19:503

  28. Most head and neck cancer (HNC) patients receive radiotherapy (RT) and develop toxicities. This genome-wide association study (GWAS) was designed to identify single nucleotide polymorphisms (SNPs) associated w...

    Authors: Elnaz Naderi, Anne Petra Gerarda Crijns, Roel Johannes Henricus Marinus Steenbakkers, Johanna Geertruida Maria van den Hoek, Hendrika Marike Boezen, Behrooz Ziad Alizadeh and Johannes Albertus Langendijk
    Citation: Journal of Translational Medicine 2021 19:481
  29. Radiotherapy (RT) still represents a mainstay of treatment in clinical oncology. Traditionally, the effectiveness of radiotherapy has been attributed to the killing potential of ionizing radiation (IR) over ma...

    Authors: Turid Hellevik, Rodrigo Berzaghi, Kristin Lode, Ashraful Islam and Inigo Martinez-Zubiaurre
    Citation: Journal of Translational Medicine 2021 19:437
  30. Compared to the other members of human epidermal growth factor family receptors (HER), the role of HER3 has not been well defined in laryngeal cancer. The predictive and prognostic role of HER3 has been the fo...

    Authors: Giovanni Almadori, Antonella Coli, Eugenio De Corso, Dario Antonio Mele, Stefano Settimi, Giovanni Di Cintio, Francesca Brigato, Domenico Scannone, Thomas E. Carey, Gaetano Paludetti, Libero Lauriola and Franco Oreste Ranelletti
    Citation: Journal of Translational Medicine 2021 19:408
  31. Solute carrier family 7 member 11(SLC7A11) is a component of cysteine/glutamate transporter, which plays a key role in tumor growth; however, its underlying effect on radiosensitivity in esophageal squamous ce...

    Authors: Lei Feng, Kaikai Zhao, Liangchao Sun, Xiaoyang Yin, Junpeng Zhang, Conghe Liu and Baosheng Li
    Citation: Journal of Translational Medicine 2021 19:367
  32. Although reports implicate radioresistance as an important obstacle for the management of breast cancer, its molecular mechanism is elusive. Herein, we found that high HDGF levels are expressed significantly i...

    Authors: Lingyun Qiu, Yan Ma, Xiaohua Chen, Liheng Zhou, Haibo Zhang, Guansheng Zhong, Lei Zhang and Jianming Tang
    Citation: Journal of Translational Medicine 2021 19:344
  33. Radiotherapy is the mainstay treatment for lung adenocarcinoma, yet remains highly susceptible to resistance. Fe3O4 magnetic nanoparticles (MNPs) possess the ability to induce biological therapeutic effects. Here...

    Authors: Shuzhen Chen, Fushi Han, Dongdong Huang, Jinqian Meng, Jiapeng Chu, Meng Wang and Peijun Wang
    Citation: Journal of Translational Medicine 2021 19:337
  34. The glutathione S-transferase P1(GSTP1) is an isoenzyme in the glutathione-S transferases (GSTs) enzyme system, which is the most abundant GSTs expressed in adult lungs. Recent research shows that GSTP1 is clo...

    Authors: Xiao Lei, Lehui Du, Wei Yu, Yao Wang, Na Ma and Baolin Qu
    Citation: Journal of Translational Medicine 2021 19:297