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Immune RadioBiology

Section edited by Claire Vanpouille-Box

The Iummne RadioBiology section is interested in innovative research that investigate the crosstalk between ionizing radiations (IR), the tumor microenvironment (TME) and host immunity. 

Studies considered for publication include (but not limited to) those investigating the mechanisms of radiation-induced anti-tumor immune responses, the immune-stimulatory and immuno-suppressive properties of ionizing radiation from all sources (X-rays, FLASH-RT, protons, carbon ion and radionuclides), biomarkers predictive of immune response, immune escape mechanisms elicited by IR and radioresistance. Importantly, the section welcomes translational and clinical studies assessing the combination of IR with immunotherapies (IT) with an emphasis on clinical response and outcome.

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  1. Radioresistance is a primary factor contributing to the failure of rectal cancer treatment. Immune suppression plays a significant role in the development of radioresistance. We have investigated the potential...

    Authors: Junxian Liang, Limin Liao, Lang Xie, WenWen Tang, Xiang Yu, Yinghao Lu, Hongzhen Chen, Juanli Xu, Lei Sun, Huanmei Wu, Chunhui Cui and Yujing Tan
    Citation: Journal of Translational Medicine 2024 22:117
  2. Radioresistance and lymph node metastasis are common phenotypes of refractory oral squamous cell carcinoma (OSCC). As a result, understanding the mechanism for radioresistance and metastatic progression is urg...

    Authors: Hui-Wen Chiu, Hsin-Lun Lee, Hsun-Hua Lee, Hsiao-Wei Lu, Kent Yu-Hsien Lin, Yuan-Feng Lin and Che-Hsuan Lin
    Citation: Journal of Translational Medicine 2024 22:13
  3. Radiosensitivity of rectal cancer is related to the radiotherapy efficacy and prognosis of patients with rectal cancer, and the genes and molecular mechanisms related to radiosensitivity of rectal cancer have ...

    Authors: Yi Liu, Yanguang Yang, Feng Ni, Guomei Tai, Cenming Yu, Xiaohui Jiang and Ding Wang
    Citation: Journal of Translational Medicine 2023 21:856
  4. KRAS activating mutations are considered the most frequent oncogenic drivers and are correlated with radio-resistance in multiple cancers including non-small cell lung cancer (NSCLC) and colorectal cancer. Althou...

    Authors: Pierre-Antoine Laurent, Marina Milic, Clément Quevrin, Lydia Meziani, Winchygn Liu, Daphné Morel, Nicolas Signolle, Céline Clémenson, Antonin Levy, Michele Mondini and Eric Deutsch
    Citation: Journal of Translational Medicine 2023 21:773
  5. Long non-coding RNA (lncRNA) HOTAIR acts importantly in liver cancer development, but its effect on radioresistance remains poorly understood. Here, our study probed into the possible impact of HOTAIR in radiores...

    Authors: Ruifeng Pei, Le Zhao, Yiren Ding, Zhan Su, Deqiang Li, Shuo Zhu, Lu Xu, Wei Zhao and Wuyuan Zhou
    Citation: Journal of Translational Medicine 2023 21:752
  6. Autophagy is involved in nasopharyngeal carcinoma (NPC) radioresistance. Replication protein A 1 (RPA1) and RPA3, substrates of the RPA complex, are potential therapeutic targets for reversing NPC radioresista...

    Authors: Yanchun Feng, Yingming Jiang, Jun Liu, Jiaqi Liu, Mengchen Shi, Junxiong Chen, Jingdan Zhang, Yu Tian, Xiangling Yang and Huanliang Liu
    Citation: Journal of Translational Medicine 2023 21:738
  7. Radiotherapy can cause kidney injury in patients with cervical cancer. This study aims to investigate the possible molecular mechanisms by which CpG-ODNs (Cytosine phosphate guanine-oligodeoxynucleotides) regu...

    Authors: Deyu Zhang, Shitai Zhang, Zheng He and Ying Chen
    Citation: Journal of Translational Medicine 2023 21:679
  8. Gene expression signatures can be used as prognostic biomarkers in various types of cancers. We aim to develop a gene signature for predicting the response to radiotherapy in glioma patients.

    Authors: Xiaonan Zhang, Qiannan Ren, Zhiyong Li, Xiaolin Xia, Wan Zhang, Yue Qin, Dehua Wu and Chen Ren
    Citation: Journal of Translational Medicine 2023 21:618
  9. Radiation-induced lung injury (RILI) is a prevalent complication of thoracic radiotherapy in cancer patients. A comprehensive understanding of the underlying mechanisms of RILI is essential for the development...

    Authors: Jianjiao Ni, Tiantian Guo, Yue Zhou, Shanshan Jiang, Long Zhang and Zhengfei Zhu
    Citation: Journal of Translational Medicine 2023 21:590
  10. Tumor hypoxia is associated with resistance to radiotherapy and chemotherapy. In head and neck squamous cell carcinoma (HNSCC), nimorazole, an oxygen mimic, combined with radiotherapy (RT) enabled to improve l...

    Authors: Lydia Koi, Verena Bitto, Corina Weise, Lisa Möbius, Annett Linge, Steffen Löck, Ala Yaromina, María José Besso, Chiara Valentini, Manuel Pfeifer, Jens Overgaard, Daniel Zips, Ina Kurth, Mechthild Krause and Michael Baumann
    Citation: Journal of Translational Medicine 2023 21:576
  11. Primary liver cancer is one of the most common malignant tumours worldwide; it caused approximately 830,000 deaths in 2020. Hepatocellular carcinoma (HCC) is the most common type of primary liver cancer, accou...

    Authors: Yuhan Yang, Liting Xiong, Mengyuan Li, Ping Jiang, Junjie Wang and Chunxiao Li
    Citation: Journal of Translational Medicine 2023 21:526
  12. Great progress has been made in applying immunotherapy to the clinical treatment of tumors. However, many patients with triple-negative breast cancer (TNBC) cannot benefit from immunotherapy due to the immune ...

    Authors: Hongpei Tan, Jiahao Liu, Jing Huang, Yanan Li, Qiongxuan Xie, Yuqian Dong, Ze Mi, Xiaoqian Ma and Pengfei Rong
    Citation: Journal of Translational Medicine 2023 21:462
  13. Animal models representing different molecular subtypes of glioblastoma multiforme (GBM) is desired for developing new therapies. SVV-001 is an oncolytic virus selectively targeting cancer cells. It’s capacity...

    Authors: Huiyuan Zhang, Yuchen Du, Lin Qi, Sophie Xiao, Frank K. Braun, Mari Kogiso, Yulun Huang, Frank Huang, Aalaa Abdallah, Milagros Suarez, Sekar Karthick, Nabil M. Ahmed, Vita S. Salsman, Patricia A. Baxter, Jack M. Su, Daniel J. Brat…
    Citation: Journal of Translational Medicine 2023 21:444
  14. Osteoradionecrosis (ORN) is a serious complication of radiotherapy for head and neck cancer (HNC). However, its etiology and pathogenesis have not been completely elucidated. Recent studies suggest the involve...

    Authors: Zhengrui Li, Rao Fu, Xufeng Huang, Xutao Wen and Ling Zhang
    Citation: Journal of Translational Medicine 2023 21:391
  15. Tumor cells with the capability of radiation resistance can escape the fate of cell death after radiotherapy, serving as the main cause of treatment failure. Repopulation of tumors after radiotherapy is domina...

    Authors: Yanwei Song, Zheng Deng, Haoran Sun, Yucui Zhao, Ruyi Zhao, Jin Cheng and Qian Huang
    Citation: Journal of Translational Medicine 2023 21:390
  16. Esophageal squamous cell carcinoma (ESCC) is a highly prevalent and aggressive cancer with poor treatment outcomes. Despite the critical role of tight junction proteins in tumorigenesis, the involvement of Cla...

    Authors: Shan Huang, Jiayi Zhang, Yi Li, Yaqiong Xu, Hui Jia, Lei An, Xiaotan Wang and Yuting Yang
    Citation: Journal of Translational Medicine 2023 21:379
  17. Interstitial lung diseases (ILDs) can be induced and even exacerbated by radiotherapy in thoracic cancer patients. The roles of immune responses underlying the development of these severe lung injuries are sti...

    Authors: Xinglong Liu, Liang Zeng, Yuchuan Zhou, Xinrui Zhao, Lin Zhu, Jianghong Zhang, Yan Pan, Chunlin Shao and Jiamei Fu
    Citation: Journal of Translational Medicine 2023 21:314
  18. Recent evidence has shown that immune checkpoint inhibitors (ICIs) are efficacious for treating brain metastases of various primary tumors. However, the immunosuppressive tumor microenvironment and the blood–b...

    Authors: Wentao Tian, Xianjing Chu, Guilong Tanzhu and Rongrong Zhou
    Citation: Journal of Translational Medicine 2023 21:244
  19. The recurrence of hepatocellular carcinoma (HCC) after radiofrequency ablation (RFA) remains a major clinical problem. Cells that survive the sublethal heat stress that is induced by incomplete RFA are the mai...

    Authors: Chao Peng, Xi Li, Feng Ao, Ting Li, Jingpei Guo, Junfeng Liu, Xiaoting Zhang, Jinyan Gu, Junjie Mao and Bin Zhou
    Citation: Journal of Translational Medicine 2023 21:218
  20. Apurinic/apyrimidinic endonuclease 1 (APE1) imparts radio-resistance by repairing isolated lesions via the base excision repair (BER) pathway, but whether and how it is involved in the formation and/or repair ...

    Authors: Qin Zhang, Lujie Yang, Han Gao, Xunjie Kuang, He Xiao, Chen Yang, Yi Cheng, Lei Zhang, Xin Guo, Yong Zhong and Mengxia Li
    Citation: Journal of Translational Medicine 2023 21:183
  21. Radiotherapy resistance is the main cause of low tumor regression for locally advanced rectum adenocarcinoma (READ). The biomarkers correlated to radiotherapy sensitivity and potential molecular mechanisms hav...

    Authors: Pengfei Zhao, Hongchao Zhen, Hong Zhao, Yongjie Huang and Bangwei Cao
    Citation: Journal of Translational Medicine 2023 21:176
  22. Alpha-emitter radiopharmaceutical therapy (αRPT) has shown promising outcomes in metastatic disease. However, the short range of the alpha particles necessitates dosimetry on a near-cellular spatial scale. Cur...

    Authors: Remco Bastiaannet, Ioanna Liatsou, Robert F Hobbs and George Sgouros
    Citation: Journal of Translational Medicine 2023 21:144
  23. Radiotherapy resistance is the main cause of treatment failure in nasopharyngeal carcinoma (NPC), which leads to poor prognosis. It is urgent to elucidate the molecular mechanisms underlying radiotherapy resis...

    Authors: Enni Chen, Jiajia Huang, Miao Chen, Jiawei Wu, Puyun Ouyang, Xiaonan Wang, Dingbo Shi, Zhiqiao Liu, Wancui Zhu, Haohui Sun, Shanshan Yang, Baoyu Zhang, Wuguo Deng, Huijuan Qiu and Fangyun Xie
    Citation: Journal of Translational Medicine 2023 21:134
  24. Preclinical evidence from us and others demonstrates that the anticancer effects of cyclin-dependent kinase 4/6 (CDK4/6) inhibitors can be enhanced with focal radiation therapy (RT), but only when RT is delive...

    Authors: Vanessa Klapp, Aitziber Buqué, Norma Bloy, Ai Sato, Takahiro Yamazaki, Xi Kathy Zhou, Silvia C. Formenti, Lorenzo Galluzzi and Giulia Petroni
    Citation: Journal of Translational Medicine 2023 21:110
  25. Nasopharyngeal carcinoma (NPC) is a kind of epithelial carcinoma that is common in East and Southeast Asia. Distant metastasis after radiotherapy remains the main cause of treatment failure and preradiotherapy...

    Authors: Xiaotian Xu, Fangze Wei, Lin Xiao, Runye Wu, Baojun Wei, Shengkai Huang, Junlin Yi and Wei Cui
    Citation: Journal of Translational Medicine 2023 21:64
  26. Radiotherapy (RT) is the standard treatment for nasopharyngeal carcinoma (NPC). However, due to individual differences in radiosensitivity, biomarkers are needed to tailored radiotherapy to cancer patients. Ho...

    Authors: Lu-Lu Yu, Bi-Wen Hu, Han-Xue Huang, Bing Yu, Qi Xiao, Qiao-Li Lv, Chen-Hui Luo, Cheng-Xian Guo, Jin-Gao Li, Xiao-Xue Xie and Ji-Ye Yin
    Citation: Journal of Translational Medicine 2023 21:11
  27. The most common form of treatment for non-metastatic lung cancer is surgery-based combination therapy, which may also include adjuvant radiotherapy or chemotherapy. Second primary malignancies (SPMs) are uncom...

    Authors: Bolun Zhou, Ruochuan Zang, Peng Song, Moyan Zhang, Fenglong Bie, Guangyu Bai, Yuan Li, Qilin Huai, Yuning Han and Shugeng Gao
    Citation: Journal of Translational Medicine 2023 21:10
  28. Sterile alpha motif domain and histidine-aspartate domain-containing protein 1 (SAMHD1) is a DNA end resection factor, which is involved in DNA damage repair and innate immunity. However, the role of SAMHD1 in...

    Authors: Yangyi Li, Yuke Gao, Xueping Jiang, Yajie Cheng, Jianguo Zhang, Liexi Xu, Xinyu Liu, Zhengrong Huang, Conghua Xie and Yan Gong
    Citation: Journal of Translational Medicine 2022 20:628
  29. Radiotherapy is one of the main treatments for esophageal squamous cell carcinoma (ESCC), but its efficacy is limited by radioresistance. MicroRNAs play a crucial role in posttranscriptional regulation, which ...

    Authors: Xiaobo Shi, Xiaoxiao Liu, Shan Huang, Yu Hao, Shupei Pan, Yue Ke, Wei Guo, Yuchen Wang and Hongbing Ma
    Citation: Journal of Translational Medicine 2022 20:626
  30. Radiation-induced lung injury (RILI) often occurs during clinical chest radiotherapy and acute irradiation from accidental nuclear leakage. This study explored the role of monophosphoryl lipid A (MPLA) in RILI.

    Authors: Xingdong Guo, Lehui Du, Na Ma, Pei Zhang, Yuan Wang, Yanan Han, Xiang Huang, Qian Zhang, Xin Tan, Xiao Lei and Baolin Qu
    Citation: Journal of Translational Medicine 2022 20:597
  31. In the management of head and neck cancer (HNC) patients, local recurrence is a common cause of treatment failure. Only a few patients with recurrent HNC (rHNC) are eligible for salvage surgery and the majorit...

    Authors: Yue Li, Yuliang Jiang, Bin Qiu, Haitao Sun and Junjie Wang
    Citation: Journal of Translational Medicine 2022 20:566
  32. This paper intends to propose a method of using TransResSEUnet2.5D network for accurate automatic segmentation of the Gross Target Volume (GTV) in Radiotherapy for lung cancer.

    Authors: Hui Xie, Zijie Chen, Jincheng Deng, Jianfang Zhang, Hanping Duan and Qing Li
    Citation: Journal of Translational Medicine 2022 20:524
  33. Radioresistance is a major cause of treatment failure in esophageal squamous cell carcinoma (ESCC) radiotherapy, and the underlying mechanisms of radioresistance are still unclear. Irradiation (IR) stimulates ...

    Authors: Xingyu Du, Xueyuan Zhang, Jing Dong, Naiyi Zou, Dong Guo, Weinan Yao, Xiaobin Wang, Shuguang Li, Chunyang Song, Ke Yan, Wenbin Shen and Shuchai Zhu
    Citation: Journal of Translational Medicine 2022 20:507
  34. Epithelial-to-mesenchymal transition (EMT) is a critical event contributing to more aggressive phenotypes in cancer cells. EMT is frequently activated in radiation-targeted cells during the course of radiother...

    Authors: Xiao-Ya Sun, Hao-Zheng Li, Da-Fei Xie, Shan-Shan Gao, Xin Huang, Hua Guan, Chen-Jun Bai and Ping-Kun Zhou
    Citation: Journal of Translational Medicine 2022 20:456
  35. Radiotherapy is the primary therapeutic option for glioblastoma. Some studies proved that radiotherapy increased the release of exosomes from cells. The mechanism by which these exosomes modify the phenotype o...

    Authors: Chunzhi Zhang, Yuan Zhou, Ya Gao, Ze Zhu, Xianliang Zeng, Weizi Liang, Songwei Sun, Xiuli Chen and Hu Wang
    Citation: Journal of Translational Medicine 2022 20:388
  36. The resistance to radiotherapy remains a major obstacle that limits the efficacy of radiotherapy in non-small cell lung cancer (NSCLC). This study aims to illustrate the molecular mechanism underlying the role...

    Authors: Li-Ming Xu, Ya-Jing Yuan, Hao Yu, Shuai Wang and Ping Wang
    Citation: Journal of Translational Medicine 2022 20:350
  37. The overall survival (OS) of stage I operable lung cancer is relatively low, and not all patients can benefit from adjuvant chemotherapy. This study aimed to develop and validate a radiomic signature (RS) for ...

    Authors: Wei Nie, Guangyu Tao, Zhenghai Lu, Jie Qian, Yaqiong Ge, Shuyuan Wang, Xueyan Zhang, Hua Zhong and Hong Yu
    Citation: Journal of Translational Medicine 2022 20:339
  38. Nasopharyngeal carcinoma (NPC) is a malignant tumor of epithelial origin in head and neck with high incidence rate in Southern China. C2orf40 has been identified as a tumor suppressor gene in many cancers. How...

    Authors: Zuozhong Xie, Wei Li, Jingang Ai, Jun Xie and Xiaowei Zhang
    Citation: Journal of Translational Medicine 2022 20:264
  39. We established a radiogenomic model to predict pathological complete response (pCR) in triple-negative breast cancer (TNBC) and explored the association between high-frequency mutations and drug resistance.

    Authors: Ying Zhang, Chao You, Yuchen Pei, Fan Yang, Daqiang Li, Yi-zhou Jiang and Zhimin Shao
    Citation: Journal of Translational Medicine 2022 20:256
  40. Nicotinamide (NAM, a variant of vitamin B3) has recently been shown to accelerate the activation of human CD4+ and CD8+ T cells exposed to repeated CD3/CD28 agonism in vitro. Here, we demonstrate that T cells inf...

    Authors: Yang Hu, Norma Bloy, Olivier Elemento and Aitziber Buqué
    Citation: Journal of Translational Medicine 2022 20:251
  41. Urinary extracellular vesicles (EVs) are a source of biomarkers with broad potential applications across clinical research, including monitoring radiation exposure. A key limitation to their implementation is ...

    Authors: Charles P. Hinzman, Meth Jayatilake, Sunil Bansal, Brian L. Fish, Yaoxiang Li, Yubo Zhang, Shivani Bansal, Michael Girgis, Anton Iliuk, Xiao Xu, Jose A. Fernandez, John H. Griffin, Elizabeth A. Ballew, Keith Unger, Marjan Boerma, Meetha Medhora…
    Citation: Journal of Translational Medicine 2022 20:199
  42. Radiotherapy is among the routine treatment options for malignant tumors. And it damages DNA and other cellular organelles in target cells by using ionizing radiation produced by various rays, killing the cell...

    Authors: Huihui Sun, Rui Sun, Xing Song, Wendong Gu and Yingjie Shao
    Citation: Journal of Translational Medicine 2022 20:189
  43. Medical applications of ionising radiation and associated radiation protection research often encounter long delays and inconsistent implementation when translated into clinical practice. A coordinated effort ...

    Authors: Sophie Bockhold, Shane J. Foley, Louise A. Rainford, Riccardo Corridori, Annika Eberstein, Christoph Hoeschen, Mark W. Konijnenberg, Susan Molyneux-Hodgson, Graciano Paulo, Joana Santos and Jonathan P. McNulty
    Citation: Journal of Translational Medicine 2022 20:137
  44. Histone deacetylases (HDACs) have been identified to be implicated in the carcinogenesis and cancer progression. The present study was performed to probe into the effect of HDAC4 on radioresistance of esophage...

    Authors: Zhonghua Lu, Yifei Yun, Yutong Zhang, Yao Ou and Meihua Wang
    Citation: Journal of Translational Medicine 2022 20:101
  45. Epidermal growth factor receptor (EGFR)-mutant lung cancers have a high risk of developing brain metastases (BM). Whole brain radiotherapy (WBRT), local radiotherapy, and WBRT + Boost are frequently used for trea...

    Authors: Guangchuan Deng, Yingyun Zhang, Jiaojiao Ke, Qi Wang, Hongyue Qin, Jianbin Li and Zhenxiang Li
    Citation: Journal of Translational Medicine 2021 19:486

    The Correction to this article has been published in Journal of Translational Medicine 2021 19:503

  46. Most head and neck cancer (HNC) patients receive radiotherapy (RT) and develop toxicities. This genome-wide association study (GWAS) was designed to identify single nucleotide polymorphisms (SNPs) associated w...

    Authors: Elnaz Naderi, Anne Petra Gerarda Crijns, Roel Johannes Henricus Marinus Steenbakkers, Johanna Geertruida Maria van den Hoek, Hendrika Marike Boezen, Behrooz Ziad Alizadeh and Johannes Albertus Langendijk
    Citation: Journal of Translational Medicine 2021 19:481