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Journal of Translational Medicine

Clinical translation

Section edited by Lana Kandalaft

This section aims to allow rapid communication of innovative early phase clinical trials, where novel scientific ideas are translated to the clinic. These include clinical trials that are distinguished for their novelty in approach, design or indication, timeliness, and unique ability to translate laboratory concepts from the bench to the bedside. Manuscripts are submitted typically at the time a clinical trial has gained full regulatory approval and is being initiated. No clinical results are required. These articles review the background, rationale, clinical design and approach, translational endpoints and expected outcomes of a new clinical trial in a scholarly manner, and provide the opportunity to investigators to share their views and clinical translation efforts with a wide audience at an early stage.

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  1. Content type: Research

    Alveolar cleft repair is performed via bone grafting procedure to restore the dental arch continuity. A suitable bone substitute materials should possess osteoinductive and osteoconductive properties, to promo...

    Authors: Mohammad Kamal, Lars Andersson, Rene Tolba, Adel Al-Asfour, Alexander K. Bartella, Felix Gremse, Stefanie Rosenhain, Frank Hölzle, Peter Kessler and Bernd Lethaus

    Citation: Journal of Translational Medicine 2017 15:263

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  2. Content type: Research

    Coexistence of enhancer of zeste homolog 2 (EZH2) and BRAF gene aberrations has been described in many cancer types. In this study, we aim to explore the coexistence status of BRAF V600E mutation and the copy num...

    Authors: Huan Yu, Meng Ma, Junya Yan, Longwen Xu, Jiayi Yu, Jie Dai, Tianxiao Xu, Huan Tang, Xiaowen Wu, Siming Li, Bin Lian, Lili Mao, Zhihong Chi, Chuanliang Cui, Jun Guo and Yan Kong

    Citation: Journal of Translational Medicine 2017 15:243

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  3. Content type: Research

    Evidence supports the existence of different subphenotypes in systemic lupus erythematosus (SLE) and the pivotal role of cytokines and autoantibodies, which interact in a highly complex network. Thus, understa...

    Authors: Yovana Pacheco, Julián Barahona-Correa, Diana M. Monsalve, Yeny Acosta-Ampudia, Manuel Rojas, Yhojan Rodríguez, Juliana Saavedra, Mónica Rodríguez-Jiménez, Rubén D. Mantilla, Carolina Ramírez-Santana, Nicolás Molano-González and Juan-Manuel Anaya

    Citation: Journal of Translational Medicine 2017 15:239

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  4. Content type: Review

    Medical imaging has become a central component of patient care to ensure early and accurate diagnosis. Unfortunately, many imaging modalities use ionizing radiation to generate images. Ionizing radiation even ...

    Authors: Tyler A. Smith, Daniel R. Kirkpatrick, Sean Smith, Trevor K. Smith, Tate Pearson, Aparna Kailasam, Kortney Z. Herrmann, Johanna Schubert and Devendra K. Agrawal

    Citation: Journal of Translational Medicine 2017 15:232

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  5. Content type: Commentary

    Immunotherapies have emerged as one of the most promising approaches to treat patients with cancer. Recently, the entire medical oncology field has been revolutionized by the introduction of immune checkpoints...

    Authors: Giuseppe V. Masucci, Alessandra Cesano, Alexander Eggermont, Bernard A. Fox, Ena Wang, Francesco M. Marincola, Gennaro Ciliberto, Kevin Dobbin, Igor Puzanov, Janis Taube, Jennifer Wargo, Lisa H. Butterfield, Lisa Villabona, Magdalena Thurin, Michael A. Postow, Paul M. Sondel…

    Citation: Journal of Translational Medicine 2017 15:223

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  6. Content type: Research

    Pigs have many features that make them attractive as biomedical models for various diseases, including cancer. P53 is an important tumor suppressor gene that exerts a central role in protecting cells from onco...

    Authors: Youfeng Shen, Kaixiang Xu, Zaimei Yuan, Jianxiong Guo, Heng Zhao, Xuezeng Zhang, Lu Zhao, Yubo Qing, Honghui Li, Weirong Pan, Baoyu Jia, Hong-Ye Zhao and Hong-Jiang Wei

    Citation: Journal of Translational Medicine 2017 15:224

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  7. Content type: Research

    Microparticles (MPs) are small (<1 μm) cell membrane-derived vesicles that are formed in response to cellular activation or early stages of apoptosis. Increased plasma MP levels have been associated with liver...

    Authors: Cornelius Engelmann, Katrin Splith, Sandra Krohn, Adam Herber, Albrecht Boehlig, Stephan Boehm, Johann Pratschke, Thomas Berg and Moritz Schmelzle

    Citation: Journal of Translational Medicine 2017 15:188

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  8. Content type: Research

    Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are severe inflammatory lung diseases. Methylprednisolone (MP) is a common drug against inflammation in clinic. In this study, we aim to i...

    Authors: Guo-wei Tu, Yi Shi, Yi-jun Zheng, Min-jie Ju, Hong-yu He, Guo-guang Ma, Guang-wei Hao and Zhe Luo

    Citation: Journal of Translational Medicine 2017 15:181

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  9. Content type: Research

    Red blood cell (RBC) depletion is a standard graft manipulation technique for ABO-incompatible bone marrow (BM) transplants. The BM processing module for Spectra Optia, “BMC”, was previously introduced. We her...

    Authors: Soo-Zin Kim-Wanner, Gesine Bug, Juliane Steinmann, Salem Ajib, Nadine Sorg, Carolin Poppe, Milica Bunos, Eva Wingenfeld, Christiane Hümmer, Beate Luxembourg, Erhard Seifried and Halvard Bonig

    Citation: Journal of Translational Medicine 2017 15:174

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  10. Content type: Review

    Most modern societies undergo rapid population aging. The rise in life expectancy, nevertheless, is not accompanied, to date, by the same increment of healthspan. Efforts to increase healthspan by means of sup...

    Authors: Alexander Vaiserman and Oleh Lushchak

    Citation: Journal of Translational Medicine 2017 15:160

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  11. Content type: Review

    While many decades of scientific research studies have gone into harnessing the power of the immune system to fight cancer, only recently have cancer immunotherapeutic approaches begun to show robust clinical ...

    Authors: Mohammad Haris, Puneet Bagga, Hari Hariharan, Bevin McGettigan-Croce, Laura A. Johnson and Ravinder Reddy

    Citation: Journal of Translational Medicine 2017 15:140

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  12. Content type: Review

    Many cancers, including breast cancer, have demonstrated prognosis and support advantages thanks to the discovery of targeted therapies. The advent of these new approaches marked the rise of precision medicine...

    Authors: Ali Bettaieb, Catherine Paul, Stéphanie Plenchette, Jingxuan Shan, Lotfi Chouchane and François Ghiringhelli

    Citation: Journal of Translational Medicine 2017 15:139

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  13. Content type: Review

    The pursuit for clarity in diagnostic and treatment pathways for the complex, chronic condition of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) continues. This systematic review raises a novel q...

    Authors: Amy Wallis, Michelle Ball, Sandra McKechnie, Henry Butt, Donald P. Lewis and Dorothy Bruck

    Citation: Journal of Translational Medicine 2017 15:129

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  14. Content type: Research

    Cell cycle dysregulation is common in human malignancies, and CDK4/6 inhibitors targeting cell cycle have potential antitumor activity. SHR6390 is a novel small molecule inhibitor specifically targeting the CD...

    Authors: Jiayuan Wang, Qingqing Li, Jiajia Yuan, Jingyuan Wang, Zuhua Chen, Zhentao Liu, Zhongwu Li, Yumei Lai, Jing Gao and Lin Shen

    Citation: Journal of Translational Medicine 2017 15:127

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  15. Content type: Research

    Electrochemotherapy (ECT), by combining manageable cytotoxic agents with short electric pulses, represents an effective palliative skin-directed therapy. The accumulated evidence indicates that ECT stands out ...

    Authors: Luca G. Campana, Roberto Marconato, Sara Valpione, Sara Galuppo, Mauro Alaibac, Carlo R. Rossi and Simone Mocellin

    Citation: Journal of Translational Medicine 2017 15:122

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  16. Content type: Research

    Metabolic syndrome (MetS) increases the risk of morbidity and mortality from cardiovascular disease, and exercise training is an important factor in the treatment and prevention of the clinical components of M...

    Authors: Robinson Ramírez-Vélez, Alejandra Tordecilla-Sanders, Luis Andrés Téllez-T, Diana Camelo-Prieto, Paula Andrea Hernández-Quiñonez, Jorge Enrique Correa-Bautista, Antonio Garcia-Hermoso, Rodrigo Ramirez-Campillo and Mikel Izquierdo

    Citation: Journal of Translational Medicine 2017 15:118

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    The Erratum to this article has been published in Journal of Translational Medicine 2017 15:136

  17. Content type: Research

    Image contrast enhanced by exogenous contrast agents plays a crucial role in the early detection, characterization, and determination of the precise location of cancers. Here, we investigate the feasibility of...

    Authors: Puneet Bagga, Mohammad Haris, Kevin D’Aquilla, Neil E. Wilson, Francesco M. Marincola, Mitchell D. Schnall, Hari Hariharan and Ravinder Reddy

    Citation: Journal of Translational Medicine 2017 15:119

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  18. Content type: Commentary

    Recent advances in molecular biology have revolutionized the concept of KIT/PDGFRA wild type (WT) gastrointestinal stromal tumors (GIST) than the past. Indeed, from being defined as GIST without KIT or PDGFRA ...

    Authors: Margherita Nannini, Milena Urbini, Annalisa Astolfi, Guido Biasco and Maria A. Pantaleo

    Citation: Journal of Translational Medicine 2017 15:113

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    The Erratum to this article has been published in Journal of Translational Medicine 2017 15:125

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