Clinical translation

Section edited by Lana Kandalaft

This section aims to allow rapid communication of innovative early phase clinical trials, where novel scientific ideas are translated to the clinic. These include clinical trials that are distinguished for their novelty in approach, design or indication, timeliness, and unique ability to translate laboratory concepts from the bench to the bedside. Manuscripts are submitted typically at the time a clinical trial has gained full regulatory approval and is being initiated. No clinical results are required. These articles review the background, rationale, clinical design and approach, translational endpoints and expected outcomes of a new clinical trial in a scholarly manner, and provide the opportunity to investigators to share their views and clinical translation efforts with a wide audience at an early stage.

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  1. Research

    Experimental approach to IGF-1 therapy in CCl4-induced acute liver damage in healthy controls and mice with partial IGF-1 deficiency

    Cell necrosis, oxidative damage, and fibrogenesis are involved in cirrhosis development, a condition in which insulin-like growth factor 1 (IGF-1) levels are diminished. This study evaluates whether the exogen...

    Luis A. Morales-Garza, Juan E. Puche, Gabriel A. Aguirre, Úrsula Muñoz, Mariano García-Magariño, Rocío G. De la Garza and Inma Castilla-Cortazar

    Journal of Translational Medicine 2017 15:96

    Published on: 4 May 2017

  2. Research

    Role of estrogen receptors and Src signaling in mechanisms of bone metastasis by estrogen receptor positive breast cancers

    Evidence shows that Luminal A breast cancer is likely to undergo bone metastasis, but the mechanisms involved remain unknown. This study’s aim was to demonstrate a correlation between estrogen receptor (ER) po...

    Jen-Hwey Chiu, Che-Sheng Wen, Jir-You Wang, Chih-Yi Hsu, Yi-Fang Tsai, Shih-Chieh Hung, Ling-Ming Tseng and Yi-Ming Shyr

    Journal of Translational Medicine 2017 15:97

    Published on: 4 May 2017

  3. Research

    Transcriptomic profiling and quantitative high-throughput (qHTS) drug screening of CDH1 deficient hereditary diffuse gastric cancer (HDGC) cells identify treatment leads for familial gastric cancer

    Patients with hereditary diffuse gastric cancer (HDGC), a cancer predisposition syndrome associated with germline mutations of the CDH1 (E-cadherin) gene, have few effective treatment options. Despite marked d...

    Ina Chen, Lesley Mathews-Greiner, Dandan Li, Abisola Abisoye-Ogunniyan, Satyajit Ray, Yansong Bian, Vivek Shukla, Xiaohu Zhang, Raj Guha, Craig Thomas, Berkley Gryder, Athina Zacharia, Joal D. Beane, Sarangan Ravichandran, Marc Ferrer and Udo Rudloff

    Journal of Translational Medicine 2017 15:92

    Published on: 1 May 2017

  4. Research

    Her2 assessment using quantitative reverse transcriptase polymerase chain reaction reliably identifies Her2 overexpression without amplification in breast cancer cases

    Immunohistochemistry (IHC) and fluorescent-in situ hybridization (FISH) are standard methods to assess human epidermal growth factor receptor 2 (HER2) status in breast cancer (BC) patients. Real-time quantitat...

    Gabriele Zoppoli, Anna Garuti, Gabriella Cirmena, Ludovica Verdun di Cantogno, Cristina Botta, Maurizio Gallo, Domenico Ferraioli, Enrico Carminati, Paola Baccini, Monica Curto, Piero Fregatti, Edoardo Isnaldi, Michela Lia, Roberto Murialdo, Daniele Friedman, Anna Sapino…

    Journal of Translational Medicine 2017 15:91

    Published on: 1 May 2017

  5. Research

    TREM-1 associated macrophage polarization plays a significant role in inducing insulin resistance in obese population

    TREM-1 acts as an amplifier of inflammation expressed on macrophages. The objective of this study was to evaluate the relationship between TREM-1 and macrophage polarization, and association of TREM-1 and M1 m...

    Saravanan Subramanian, Pradeep K. Pallati, Poonam Sharma, Devendra K. Agrawal and Kalyana C. Nandipati

    Journal of Translational Medicine 2017 15:85

    Published on: 28 April 2017

  6. Research

    Longitudinal analysis of serum oxylipin profile as a novel descriptor of the inflammatory response to surgery

    Oxylipins are potent lipid mediators demonstrated to initiate and regulate inflammation yet little is known regarding their involvement in the response to surgical trauma. As key modulators of the inflammatory...

    Arnaud M. Wolfer, Alasdair J. Scott, Claudia Rueb, Mathieu Gaudin, Ara Darzi, Jeremy K. Nicholson, Elaine Holmes and James M. Kinross

    Journal of Translational Medicine 2017 15:83

    Published on: 26 April 2017

  7. Research

    Veliparib in combination with radiotherapy for the treatment of MGMT unmethylated glioblastoma

    The O 6 -methylguanine methyltransferase (MGMT) gene is frequently unmethylated in patients with glioblastoma (GBM), rendering them non-responsive...

    Toni Rose Jue, Kyoko Nozue, Ashleigh J. Lester, Swapna Joshi, Lisette B. W. Schroder, Shane P. Whittaker, Sheri Nixdorf, Robert W. Rapkins, Mustafa Khasraw and Kerrie L. McDonald

    Journal of Translational Medicine 2017 15:61

    Published on: 17 March 2017

  8. Research

    FTY720 inhibits mesothelioma growth in vitro and in a syngeneic mouse model

    Malignant mesothelioma (MM) is a very aggressive type of cancer, with a dismal prognosis and inherent resistance to chemotherapeutics. Development and evaluation of new therapeutic approaches is highly needed....

    Agata Szymiczek, Sandra Pastorino, David Larson, Mika Tanji, Laura Pellegrini, Jiaming Xue, Shuangjing Li, Carlotta Giorgi, Paolo Pinton, Yasutaka Takinishi, Harvey I. Pass, Hideki Furuya, Giovanni Gaudino, Andrea Napolitano, Michele Carbone and Haining Yang

    Journal of Translational Medicine 2017 15:58

    Published on: 15 March 2017

  9. Research

    Luteolin suppresses gastric cancer progression by reversing epithelial-mesenchymal transition via suppression of the Notch signaling pathway

    Gastric cancer (GC) is one of the most malignant tumors and the second leading cause of cancer-related deaths in the world. Luteolin, a flavonoid present in many fruits and green plants, suppresses cancer prog...

    Ming-de Zang, Lei Hu, Zhi-yuan Fan, He-xiao Wang, Zheng-lun Zhu, Shu Cao, Xiong-yan Wu, Jian-fang Li, Li-ping Su, Chen Li, Zheng-gang Zhu, Min Yan and Bing-ya Liu

    Journal of Translational Medicine 2017 15:52

    Published on: 27 February 2017

  10. Research

    A rabbit model for experimental alveolar cleft grafting

    The purpose of the present study was to develop an animal model for creating alveolar cleft defects with properly simulated clinical defect environment for tissue-engineered bone-substitute materials testing w...

    Mohammad Kamal, Lars Andersson, Rene Tolba, Alexander Bartella, Felix Gremse, Frank Hölzle, Peter Kessler and Bernd Lethaus

    Journal of Translational Medicine 2017 15:50

    Published on: 24 February 2017

  11. Methodology

    Generation of donor-specific Tr1 cells to be used after kidney transplantation and definition of the timing of their in vivo infusion in the presence of immunosuppression

    Operational tolerance is an alternative to lifelong immunosuppression after transplantation. One strategy to achieve tolerance is by T regulatory cells. Safety and feasibility of a T regulatory type 1 (Tr1)-ce...

    Bechara Mfarrej, Eleonora Tresoldi, Angela Stabilini, Alessia Paganelli, Rossana Caldara, Antonio Secchi and Manuela Battaglia

    Journal of Translational Medicine 2017 15:40

    Published on: 21 February 2017

  12. Research

    Distinct patterns and prognostic values of tumor-infiltrating macrophages in hepatocellular carcinoma and gastric cancer

    Macrophages (Mφs) constitute a major component of the leukocyte infiltrate and perform distinct roles in different tumor microenvironments. This study aimed to characterize the distribution, composition and pr...

    Jin-Qing Li, Xing-Juan Yu, Yong-Chun Wang, Li-Yun Huang, Chao-Qun Liu, Limin Zheng, Yu-jing Fang and Jing Xu

    Journal of Translational Medicine 2017 15:37

    Published on: 15 February 2017

  13. Methodology

    Lymph node pooling: a feasible and efficient method of lymph node molecular staging in colorectal carcinoma

    Pathologic lymph node staging is becoming a deficient method in the demanding molecular era. Nevertheless, the use of more sensitive molecular analysis for nodal staging is hampered by its high costs and exte...

    Natalia Rakislova, Carla Montironi, Iban Aldecoa, Eva Fernandez, Josep Antoni Bombi, Mireya Jimeno, Francesc Balaguer, Maria Pellise, Antoni Castells and Miriam Cuatrecasas

    Journal of Translational Medicine 2017 15:14

    Published on: 14 January 2017

  14. Research

    B cell repertoires in HLA-sensitized kidney transplant candidates undergoing desensitization therapy

    Kidney transplantation is the most effective treatment for end-stage renal disease. Sensitization refers to pre-existing antibodies against human leukocyte antigen (HLA) protein and remains a major barrier to ...

    John F. Beausang, H. Christina Fan, Rene Sit, Maria U. Hutchins, Kshama Jirage, Rachael Curtis, Edward Hutchins, Stephen R. Quake and Julie M. Yabu

    Journal of Translational Medicine 2017 15:9

    Published on: 13 January 2017

  15. Methodology

    Advances in rare cell isolation: an optimization and evaluation study

    Rare nucleated CD45 negative cells in peripheral blood may be malignant such as circulating tumor cells. Untouched isolation thereof by depletion of normal is favored yet still technological challenging. We op...

    Stefan Schreier, Piamsiri Sawaisorn, Rachanee Udomsangpetch and Wannapong Triampo

    Journal of Translational Medicine 2017 15:6

    Published on: 5 January 2017

  16. Research

    Mobilization of hematopoietic stem cells with the novel CXCR4 antagonist POL6326 (balixafortide) in healthy volunteers—results of a dose escalation trial

    Certain disadvantages of the standard hematopoietic stem and progenitor cell (HSPC) mobilizing agent G-CSF fuel the quest for alternatives. We herein report results of a Phase I dose escalation trial comparing...

    Darja Karpova, Susanne Bräuninger, Eliza Wiercinska, Ariane Krämer, Belinda Stock, Jochen Graff, Hans Martin, Achim Wach, Christophe Escot, Garry Douglas, Barbara Romagnoli, Eric Chevalier, Klaus Dembowski, Leon Hooftman and Halvard Bonig

    Journal of Translational Medicine 2017 15:2

    Published on: 3 January 2017

  17. Research

    LncRNA MALAT1 promotes development of mantle cell lymphoma by associating with EZH2

    Mantle cell lymphoma (MCL) is considered an aggressive subtype of non-Hodgkin’s lymphoma with variable treatment responses. There is an urgent need to identify novel markers with prognostic and therapeutic val...

    Xin Wang, Lalit Sehgal, Neeraj Jain, Tamer Khashab, Rohit Mathur and Felipe Samaniego

    Journal of Translational Medicine 2016 14:346

    Published on: 20 December 2016

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