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Clinical translation

Section edited by Lana Kandalaft

This section aims to allow rapid communication of innovative early phase clinical trials, where novel scientific ideas are translated to the clinic. These include clinical trials that are distinguished for their novelty in approach, design or indication, timeliness, and unique ability to translate laboratory concepts from the bench to the bedside. Manuscripts are submitted typically at the time a clinical trial has gained full regulatory approval and is being initiated. No clinical results are required. These articles review the background, rationale, clinical design and approach, translational endpoints and expected outcomes of a new clinical trial in a scholarly manner, and provide the opportunity to investigators to share their views and clinical translation efforts with a wide audience at an early stage.

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  1. Non-alcoholic fatty liver disease (NAFLD) is characterized by triglyceride accumulation in the hepatocytes in the absence of alcohol overconsumption, commonly associated with insulin resistance and obesity. Bo...

    Authors: Benedetta M. Motta, Christoph Grander, Martin Gögele, Luisa Foco, Vladimir Vukovic, Roberto Melotti, Christian Fuchsberger, Alessandro De Grandi, Chiara Cantaloni, Anne Picard, Deborah Mascalzoni, Alessandra Rossini, Cristian Pattaro, Herbert Tilg and Peter P. Pramstaller

    Citation: Journal of Translational Medicine 2019 17:408

    Content type: Protocol

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  2. Most ovarian cancer patients are diagnosed at a late stage with 85% of them relapsing after surgery and standard chemotherapy; for this reason, new treatments are urgently needed. Ovarian cancer has become a c...

    Authors: Apostolos Sarivalasis, Caroline Boudousquié, Klara Balint, Brian J. Stevenson, Philippe O. Gannon, Emanuela Marina Iancu, Laetitia Rossier, Silvia Martin Lluesma, Patrice Mathevet, Christine Sempoux, George Coukos, Urania Dafni, Alexandre Harari, Michal Bassani-Sternberg and Lana E. Kandalaft

    Citation: Journal of Translational Medicine 2019 17:391

    Content type: Protocol

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  3. World Trade Center (WTC) responders were exposed to mixture of dust, smoke, chemicals and carcinogens. New York University (NYU) and Mount Sinai have recreated WTC exposure in rodents to observe the resulting ...

    Authors: Wil Lieberman-Cribbin, Stephanie Tuminello, Christina Gillezeau, Maaike van Gerwen, Rachel Brody, David J. Mulholland, Lori Horton, Maureen Sisco, Colette Prophete, Judith Zelikoff, Hyun-Wook Lee, Sung-Hyun Park, Lung-Chi Chen, Mitchell D. Cohen and Emanuela Taioli

    Citation: Journal of Translational Medicine 2019 17:342

    Content type: Research

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  4. The role of body fat distribution in uric acid metabolism is still ambiguity. We aimed to investigate the independent contribution of visceral adipose measured by visceral adiposity index and lipid accumulatio...

    Authors: Xiaolin Huang, Xiaohong Jiang, Long Wang, Lu Chen, Yang Wu, Pei Gao and Fei Hua

    Citation: Journal of Translational Medicine 2019 17:341

    Content type: Research

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  5. In colorectal cancer surgery there is a delicate balance between complete removal of the tumor and sparing as much healthy tissue as possible. Especially in rectal cancer, intraoperative tissue recognition cou...

    Authors: E. J. M. Baltussen, S. G. Brouwer de Koning, J. Sanders, A. G. J. Aalbers, N. F. M. Kok, G. L. Beets, B. H. W. Hendriks, H. J. C. M. Sterenborg, K. F. D. Kuhlmann and T. J. M. Ruers

    Citation: Journal of Translational Medicine 2019 17:333

    Content type: Research

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  6. Acute traumatic cervical spinal cord injury (SCI) is a leading cause of disability in adolescents and young adults worldwide. Evidence from previous studies suggests that circulating cell-free DNA is associate...

    Authors: Hung-Chen Wang, Yu-Tsai Lin, Shih-Yuan Hsu, Nai-Wen Tsai, Yun-Ru Lai, Ben Yu-Jih Su, Chia-Te Kung and Cheng-Hsien Lu

    Citation: Journal of Translational Medicine 2019 17:329

    Content type: Research

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  7. Treatment with anti-PD1 monoclonal antibodies improves the survival of metastatic melanoma patients but only a subgroup of patients benefits from durable disease control. Predictive biomarkers for durable bene...

    Authors: Teofila Seremet, Yanina Jansen, Simon Planken, Hassan Njimi, Mélanie Delaunoy, Hakim El Housni, Gil Awada, Julia Katharina Schwarze, Marleen Keyaerts, Hendrik Everaert, Danielle Lienard, Véronique Del Marmol, Pierre Heimann and Bart Neyns

    Citation: Journal of Translational Medicine 2019 17:303

    Content type: Research

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  8. Over many years, OM-85, a lysate of 21 common bacterial respiratory pathogens, has been demonstrated to prevent respiratory recurrences in children. However, further studies are needed to explore the true impo...

    Authors: Susanna Esposito, Sonia Bianchini, Samantha Bosis, Claudia Tagliabue, Ilaria Coro, Alberto Argentiero and Nicola Principi

    Citation: Journal of Translational Medicine 2019 17:284

    Content type: Research

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  9. Hypothermia, leading to mitochondrial inhibition, is widely used to reduce ischemic injury during kidney preservation. However, the exact effect of hypothermic kidney preservation on mitochondrial function rem...

    Authors: Koen D. W. Hendriks, Isabel M. A. Brüggenwirth, Hanno Maassen, Albert Gerding, Barbara Bakker, Robert J. Porte, Robert H. Henning and Henri G. D. Leuvenink

    Citation: Journal of Translational Medicine 2019 17:265

    Content type: Research

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  10. Lung cancer is the second most common cancer with an extremely poor overall survival rate. Post-transcriptional regulation of gene expression play many important roles in human cancer, and one of the potential...

    Authors: Shirong Zhang, Xiaochen Zhang, Wei Lei, Jiafeng Liang, Yasi Xu, Hailiang Liu and Shenglin Ma

    Citation: Journal of Translational Medicine 2019 17:257

    Content type: Research

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  11. Melanoma is one of the most aggressive cancers with extremely poor prognosis, and the median survival time for stage IV patients is approximately 6 to 8 months. Unlike cutaneous melanoma, mucosal melanoma is a...

    Authors: Longwen Xu, Zhiyuan Cheng, Chuanliang Cui, Xiaowen Wu, Huan Yu, Jun Guo and Yan Kong

    Citation: Journal of Translational Medicine 2019 17:245

    Content type: Research

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    The Correction to this article has been published in Journal of Translational Medicine 2019 17:358

  12. Despite of medical advances, the number of patients suffering on non-healing chronic wounds is still increasing. This fact is attended by physical and emotional distress and an economic load. The majority of c...

    Authors: M. Besser, J. Terberger, L. Weber, B. Ghebremedhin, E. A. Naumova, W. H. Arnold and E. K. Stuermer

    Citation: Journal of Translational Medicine 2019 17:243

    Content type: Research

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  13. Wolfram syndrome (WS), a rare genetic disorder, is considered the best prototype of endoplasmic reticulum (ER) diseases. Classical WS features are childhood-onset diabetes mellitus, optic atrophy, deafness, di...

    Authors: Maria Teresa Pallotta, Giorgia Tascini, Roberta Crispoldi, Ciriana Orabona, Giada Mondanelli, Ursula Grohmann and Susanna Esposito

    Citation: Journal of Translational Medicine 2019 17:238

    Content type: Review

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  14. Neutrophil gelatinase-associated lipocalin (NGAL) is a promising biomarker of early diagnosis and prediction for acute kidney injury (AKI). However, the current program for NGAL detection is not extensively ap...

    Authors: Xiaoqian Hong, Huihui Yan, Fuan Xie, Kaiyu Wang, Qiang Wang, Huijuan Huang, Kunrong Yang, Suhong Huang, Tingting Zhao, Junkai Wang, Yunyun Chen, Kuancan Liu and Xiaopeng Lan

    Citation: Journal of Translational Medicine 2019 17:204

    Content type: Research

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  15. Orthostatic intolerance (OI) is a significant problem for those with chronic fatigue syndrome (CFS). We aimed to characterize orthostatic intolerance in CFS and to study the effects of exercise on OI.

    Authors: Richard Garner and James N. Baraniuk

    Citation: Journal of Translational Medicine 2019 17:185

    Content type: Research

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  16. There is an urgent need for novel and effective treatment options for acute myeloid leukemia (AML). Triptolide, a diterpenoid tri-epoxide compound isolated from the herb Tripterygium wilfordii and its water-solub...

    Authors: Bhuwan Giri, Vineet K. Gupta, Brianna Yaffe, Shrey Modi, Pooja Roy, Vrishketan Sethi, Shweta P. Lavania, Selwyn M. Vickers, Vikas Dudeja, Sulagna Banerjee, Justin Watts and Ashok Saluja

    Citation: Journal of Translational Medicine 2019 17:163

    Content type: Research

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    The Correction to this article has been published in Journal of Translational Medicine 2019 17:301

  17. Nutrition of the newborn during the early postnatal period seems to be of capital importance and there is clinical evidence showing the protective effect of breastfeeding compared with formula feeding on child...

    Authors: Julio Alvarez-Pitti, Maria Amparo Ros-Forés, Ana Bayo-Pérez, Mariona Palou, Empar Lurbe, Andreu Palou and Catalina Picó

    Citation: Journal of Translational Medicine 2019 17:145

    Content type: Research

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  18. Remote ischemic preconditioning (RIPC) is a phenomenon, whereby repeated, non-lethal episodes of ischemia to an organ or limb exert protection against ischemia–reperfusion (I/R) injury in distant organs. Despi...

    Authors: Lars Hummitzsch, Karina Zitta, Rouven Berndt, Yuk Lung Wong, Rene Rusch, Katharina Hess, Thilo Wedel, Matthias Gruenewald, Jochen Cremer, Markus Steinfath and Martin Albrecht

    Citation: Journal of Translational Medicine 2019 17:136

    Content type: Research

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  19. Low back pain has become a serious social and economic burden and the leading cause of disability worldwide. Among a variety of pathophysiological triggers, intervertebral disc (IVD) degeneration plays a prima...

    Authors: Xubin Qiu, Ming Zhuang, Ziwen Lu, Zhiwei Liu, Dong Cheng, Chenlei Zhu and Jinbo Liu

    Citation: Journal of Translational Medicine 2019 17:135

    Content type: Research

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  20. Keto-analogues administration plays an important role in clinical chronic kidney disease (CKD) adjunctive therapy, however previous studies on their reno-protective effect mainly focused on kidney pathological...

    Authors: Meng Wang, Huzi Xu, Octavia Li-Sien Chong Lee Shin, Li Li, Hui Gao, Zhi Zhao, Fan Zhu, Han Zhu, Wangqun Liang, Kun Qian, Chunxiu Zhang, Rui Zeng, Hanjing Zhou and Ying Yao

    Citation: Journal of Translational Medicine 2019 17:122

    Content type: Research

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  21. OZ439 is a new chemical entity which is active against drug-resistant malaria and shows potential as a single-dose cure. However, development of an oral formulation with desired exposure has proved problematic...

    Authors: Kurt D. Ristroph, Jie Feng, Simon A. McManus, Yingyue Zhang, Kai Gong, Hanu Ramachandruni, Claire E. White and Robert K. Prud’homme

    Citation: Journal of Translational Medicine 2019 17:97

    Content type: Research

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  22. Excess dietary sodium is not only excreted by the kidneys, but can also be stored by non-osmotic binding with glycosaminoglycans in dermal connective tissue. Such storage has been associated with dermal inflam...

    Authors: Ryanne S. Hijmans, Marco van Londen, Kwaku A. Sarpong, Stephan J. L. Bakker, Gerjan J. Navis, Twan T. R. Storteboom, Wilhelmina H. A. de Jong, Robert A. Pol and Jacob van den Born

    Citation: Journal of Translational Medicine 2019 17:88

    Content type: Research

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  23. There are no known objective biomarkers to assist with the diagnosis of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS). A small number of studies have shown that ME/CFS patients exhibit an earlier...

    Authors: Maximillian J. Nelson, Jonathan D. Buckley, Rebecca L. Thomson, Daniel Clark, Richard Kwiatek and Kade Davison

    Citation: Journal of Translational Medicine 2019 17:80

    Content type: Research

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  24. Previous studies from this as well as other research groups suggested that non-invasive chromosome screening (NICS) with embryo culture medium can be used to identify chromosomal ploidy and chromosomal abnorma...

    Authors: Rui Fang, Weimin Yang, Xin Zhao, Fang Xiong, Caiqing Guo, Jianping Xiao, Li Chen, Xiaoqing Song, Honghua Wang, Jie Chen, Xiao Xiao, Bing Yao and Li-Yi Cai

    Citation: Journal of Translational Medicine 2019 17:73

    Content type: Research

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  25. Visible light spectroscopy (VLS) is a technique used to measure the mucosal oxygen saturation during upper gastrointestinal endoscopy to evaluate mucosal ischemia, however in vivo validation is lacking. We aim...

    Authors: Rinse Ubbink, Louisa J. D. van Dijk, Desirée van Noord, Tanja Johannes, Patricia A. C. Specht, Marco J. Bruno and Egbert G. Mik

    Citation: Journal of Translational Medicine 2019 17:65

    Content type: Research

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  26. Marshallese face significant health disparities, with particularly high rates of type 2 diabetes. Engaging stakeholders in the research process is essential to reduce health inequities.

    Authors: Pearl A. McElfish, Britni L. Ayers, Holly C. Felix, Christopher R. Long, Zoran Bursac, Joseph Keawe‘aimoku Kaholokula, Sheldon Riklon, Williamina Bing, Anita Iban and Karen Hye-cheon Kim Yeary

    Citation: Journal of Translational Medicine 2019 17:42

    Content type: Research

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  27. Systemic inflammation and immune dysfunction have been proved to be associated with cancer progression and metastasis in various malignancies. The aim of this retrospective study was to evaluate the prognostic...

    Authors: Ke Zhang, Yong-Qiang Hua, Dan Wang, Lian-Yu Chen, Cai-Jun Wu, Zhen Chen, Lu-Ming Liu and Hao Chen

    Citation: Journal of Translational Medicine 2019 17:30

    Content type: Research

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  28. The epithelial to mesenchymal transition (EMT) is a multi-factorial biological mechanism involved in renal and hepatic fibrosis and the IL-1 beta has been assumed as a mediator of this process although data ar...

    Authors: Valentina Masola, Amedeo Carraro, Simona Granata, Lorenzo Signorini, Gloria Bellin, Paola Violi, Antonio Lupo, Umberto Tedeschi, Maurizio Onisto, Giovanni Gambaro and Gianluigi Zaza

    Citation: Journal of Translational Medicine 2019 17:12

    Content type: Research

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  29. Total temporomandibular joint (TMJ) prosthesis is an effective and reliable method of joint reconstruction. However, there is still an urgent need to design a new TMJ prosthesis because of no commercially avai...

    Authors: JiSi Zheng, XuZhuo Chen, WenBo Jiang, ShanYong Zhang, MinJie Chen and Chi Yang

    Citation: Journal of Translational Medicine 2019 17:4

    Content type: Research

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  30. The clinical significance of fibroblast growth factor receptor 1 (FGFR1) protein expression in pancreatic cancer is largely unknown. In this study, we aimed investigate the clinical significance of FGFR1 expre...

    Authors: Farhan Haq, You-Na Sung, Inkeun Park, Mahmood Akhtar Kayani, Faizah Yousuf, Seung-Mo Hong and Sung-Min Ahn

    Citation: Journal of Translational Medicine 2018 16:374

    Content type: Research

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  31. To investigate diffusion-weighted magnetic imaging (DWI) and diffusion kurtosis magnetic imaging (DKI) for the early detection of the response to docetaxel (DTX) chemotherapy in rat epithelial ovarian cancer (...

    Authors: Su-juan Yuan, Tian-kui Qiao and Jin-Wei Qiang

    Citation: Journal of Translational Medicine 2018 16:340

    Content type: Research

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  32. Recent studies have suggested a possible association between heparin treatment at the time of cell-free DNA (cfDNA) testing and a non-reportable result. However, these studies lack of proper methodology and ha...

    Authors: Yohann Dabi, Sarah Guterman, Jacques C. Jani, Alexandra Letourneau, Adèle Demain, Pascale Kleinfinger, Laurence Lohmann, Jean-Marc Costa and Alexandra Benachi

    Citation: Journal of Translational Medicine 2018 16:335

    Content type: Research

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  33. While auditory neuropathy spectrum disorder (ANSD) is a heterogeneous disorder and its management quite varies depending upon the etiology, even including self-resolution, OTOF is an important molecular etiology ...

    Authors: Bong Jik Kim, Jeong Hun Jang, Jin Hee Han, Hye-Rim Park, Doo Yi Oh, Seungmin Lee, Min Young Kim, Ah Reum Kim, Chung Lee, Nayoung K. D. Kim, Woong-Yang Park, Yun-Hoon Choung and Byung Yoon Choi

    Citation: Journal of Translational Medicine 2018 16:330

    Content type: Research

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  34. The prognostic impact of surgical paraaortic staging remains unclear in patients with locally advanced cervical cancer (LACC). The objective of our study was to evaluate the survival impact of surgical staging...

    Authors: Yohann Dabi, Vanille Simon, Xavier Carcopino, Sofiane Bendifallah, Lobna Ouldamer, Vincent Lavoue, Geoffroy Canlorbe, Emilie Raimond, Charles Coutant, Olivier Graesslin, Pierre Collinet, Alexandre Bricou, Emile Daraï, Cyrille Huchon, Marcos Ballester, Bassam Haddad…

    Citation: Journal of Translational Medicine 2018 16:326

    Content type: Research

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  35. The diagnosis of metastasis by sentinel lymph node biopsy (SLNB) in early breast cancer surgery provides an accurate view of the state of metastases to the axillary lymph nodes, and it has now become the stand...

    Authors: Koji Takada, Shinichiro Kashiwagi, Wataru Goto, Yuka Asano, Katsuyuki Takahashi, Hisakazu Fujita, Tsutomu Takashima, Shuhei Tomita, Kosei Hirakawa and Masaichi Ohira

    Citation: Journal of Translational Medicine 2018 16:318

    Content type: Research

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  36. The prognosis of breast cancer and the treatment response to neoadjuvant chemotherapy (NAC) differ depending on the intrinsic molecular subtypes. We evaluated the prognostic significance of immunohistological ...

    Authors: Wataru Goto, Shinichiro Kashiwagi, Koji Takada, Yuka Asano, Katsuyuki Takahashi, Hisakazu Fujita, Tsutomu Takashima, Shuhei Tomita, Kosei Hirakawa and Masaichi Ohira

    Citation: Journal of Translational Medicine 2018 16:307

    Content type: Research

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  37. The pharmaceutical industry is in the midst of a productivity crisis and rates of translation from bench to bedside are dismal. Patients are being let down by the current system of drug discovery; of the sever...

    Authors: Pandora Pound and Merel Ritskes-Hoitinga

    Citation: Journal of Translational Medicine 2018 16:304

    Content type: Review

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  38. We have previously shown that podocalyxin-like protein (PODXL) is a prognostic biomarker for poor survival in gastric and esophageal adenocarcinoma treated with surgery up-front. The aim of the present study w...

    Authors: David Borg, Anna H. Larsson, Charlotta Hedner, Björn Nodin, Anders Johnsson and Karin Jirström

    Citation: Journal of Translational Medicine 2018 16:290

    Content type: Research

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  39. Liquid biopsy approaches, such as measuring circulating tumour cells (CTCs), have recently been introduced in several clinical studies. However, the development of CTCs as a predictive marker for treatment eff...

    Authors: Yoshiya Horimoto, Emi Tokuda, Fumi Murakami, Toshitaka Uomori, Takanori Himuro, Katsuya Nakai, Gotaro Orihata, Kotaro Iijima, Shinsaku Togo, Hideo Shimizu and Mitsue Saito

    Citation: Journal of Translational Medicine 2018 16:287

    Content type: Research

    Published on:

  40. World Trade Center (WTC) responders were exposed to mixture of dust, smoke, chemicals and carcinogens. Studies of cancer incidence in this population have reported elevated risks of cancer compared to the gene...

    Authors: Wil Lieberman-Cribbin, Stephanie Tuminello, Christina Gillezeau, Maaike van Gerwen, Rachel Brody, Michael Donovan and Emanuela Taioli

    Citation: Journal of Translational Medicine 2018 16:280

    Content type: Research

    Published on:

  41. Traumatic spinal cord injury (SCI) results in sensory and motor function impairment and may cause a substantial social and economic burden. For the implementation of novel treatment strategies, parallel develo...

    Authors: Adriano Wang-Leandro, Marc K. Hobert, Sabine Kramer, Karl Rohn, Veronika M. Stein and Andrea Tipold

    Citation: Journal of Translational Medicine 2018 16:258

    Content type: Research

    Published on:

  42. Radiation-induced kidney damage can severely affect renal function, and have a serious impact on glucose reabsorption. Fluoro-2-deoxyglucose positron emission tomography (FDG-PET) is routinely utilized for met...

    Authors: Yu-Guang Tian, Min Yue, Bayaer Nashun, Shao-Jie Wu, Wei-Wang Gu and Yu-Jue Wang

    Citation: Journal of Translational Medicine 2018 16:257

    Content type: Research

    Published on:

  43. The use of circulating tumor cells (CTCs) as indicators of treatment response in metastatic colorectal cancer (mCRC) needs to be clarified. The objective of this study is to compare the Response Evaluation Cri...

    Authors: Mayte Delgado-Ureña, Francisco G. Ortega, Diego de Miguel-Pérez, Alba Rodriguez-Martínez, Jose L. García-Puche, Hugh Ilyine, Jose A. Lorente, Jose Exposito-Hernandez, M. Carmen Garrido-Navas, Miguel Delgado-Ramirez and M. José Serrano

    Citation: Journal of Translational Medicine 2018 16:251

    Content type: Research

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  44. Cytokine-induced killer (CIK) cells are a very promising cell population raising growing interest in the field of cellular antitumor therapy. The aim of our study was to validate the most advantageous expansio...

    Authors: Sara Castiglia, Aloe Adamini, Deborah Rustichelli, Laura Castello, Katia Mareschi, Giuseppe Pinnetta, Marco Leone, Alessandra Mandese, Ivana Ferrero, Giulia Mesiano and Franca Fagioli

    Citation: Journal of Translational Medicine 2018 16:237

    Content type: Methodology

    Published on:

    The Correction to this article has been published in Journal of Translational Medicine 2018 16:275

  45. A relationship between rheumatoid arthritis (RA) and periodontitis has been suggested from findings that individuals with RA are prone to have advanced periodontitis and vice versa. In search of possible commo...

    Authors: Marianne Engström, Kaja Eriksson, Linkiat Lee, Monika Hermansson, Anders Johansson, Anthony P. Nicholas, Natalija Gerasimcik, Karin Lundberg, Lars Klareskog, Anca Irinel Catrina and Tülay Yucel-Lindberg

    Citation: Journal of Translational Medicine 2018 16:214

    Content type: Research

    Published on:

  46. Metastatic melanoma represents a challenging clinical situation and, until relatively recently, there was an absence of effective treatment options. However, in 2011, the advanced melanoma treatment landscape ...

    Authors: Paolo A. Ascierto, Igor Puzanov, Sanjiv S. Agarwala, Carlo Bifulco, Gerardo Botti, Corrado Caracò, Gennaro Ciliberto, Michael A. Davies, Reinhard Dummer, Soldano Ferrone, Thomas F. Gajewski, Claus Garbe, Jason J. Luke, Francesco M. Marincola, Giuseppe Masucci, Janice M. Mehnert…

    Citation: Journal of Translational Medicine 2018 16:207

    Content type: Meeting report

    Published on:

  47. Sperm selection is essential for the health of offspring conceived via assistive reproductive technology (ART). Various methods of sperm preparation for in vitro fertilization and intracytoplasmic sperm inject...

    Authors: Kun Li, Rui Li, Ya Ni, Peibei Sun, Ye Liu, Dan Zhang and Hefeng Huang

    Citation: Journal of Translational Medicine 2018 16:203

    Content type: Research

    Published on:

  48. Ovarian cancer has no definitive second line therapeutic options, and largely recurs in the peritoneal cavity. Locoregional immune therapy using both interferons and monocytes can be used as a novel approach. ...

    Authors: Daniel S. Green, Ana T. Nunes, Virginia David-Ocampo, Irene B. Ekwede, Nicole D. Houston, Steven L. Highfill, Hanh Khuu, David F. Stroncek, Seth M. Steinberg, Kathryn C. Zoon and Christina M. Annunziata

    Citation: Journal of Translational Medicine 2018 16:196

    Content type: Protocol

    Published on:

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