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Clinical translation

Section edited by Lana Kandalaft

This section aims to allow rapid communication of innovative early phase clinical trials, where novel scientific ideas are translated to the clinic. These include clinical trials that are distinguished for their novelty in approach, design or indication, timeliness, and unique ability to translate laboratory concepts from the bench to the bedside. Manuscripts are submitted typically at the time a clinical trial has gained full regulatory approval and is being initiated. No clinical results are required. These articles review the background, rationale, clinical design and approach, translational endpoints and expected outcomes of a new clinical trial in a scholarly manner, and provide the opportunity to investigators to share their views and clinical translation efforts with a wide audience at an early stage.

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  1. Content type: Review

    Successful oncological drug development for bone and soft tissue sarcoma is grossly stagnating. A major obstacle in this process is the lack of appropriate animal models recapitulating the complexity and heter...

    Authors: Wan Lu, Tu Chao, Chen Ruiqi, Su Juan and Li Zhihong

    Citation: Journal of Translational Medicine 2018 16:107

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  2. Content type: Meeting report

    As part of the 2017 Melanoma Bridge congress (November 30–December 2, 2017, Napoli, Italy), the great debate session featured counterpoint views from leading experts on three contemporary controversial clinica...

    Authors: Paolo A. Ascierto, Corrado Caracò, Jeffrey E. Gershenwald, Omid Hamid, Merrick Ross, Ryan J. Sullivan and Igor Puzanov

    Citation: Journal of Translational Medicine 2018 16:101

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  3. Content type: Research

    Recurrent pregnancy loss (RPL) occurs in 3–5% in about 30% of cases no cause can be found. Women with RPL show higher prevalence of undiagnosed gut disorders. Furthermore, in endometrial tissues of RPL women, ...

    Authors: C. Tersigni, S. D’Ippolito, F. Di Nicuolo, R. Marana, V. Valenza, V. Masciullo, F. Scaldaferri, F. Malatacca, C. de Waure, A. Gasbarrini, G. Scambia and N. Di Simone

    Citation: Journal of Translational Medicine 2018 16:102

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  4. Content type: Research

    ALK rearrangement-advanced NSCLC patients respond to crizotinib. ALK rearrangement is currently determined with RT-PCR. VENTANA IHC is a standard method to identify ALK protein overexpression in NSCLC; however, V...

    Authors: Chun-wei Xu, Wen-xian Wang, Yan-ping Chen, Yu Chen, Wei Liu, Li-hua Zhong, Fang-fang Chen, Wu Zhuang, Zheng-bo Song, Xiao-hui Chen, Yun-jian Huang, Yan-fang Guan, Xin Yi, Tang-feng Lv, Wei-feng Zhu, Jian-ping Lu…

    Citation: Journal of Translational Medicine 2018 16:93

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  5. Content type: Research

    Articular cartilage degeneration plays a key role in the pathogenesis of osteoarthritis (OA). Bushenhuoxue formula (BSHXF) has been widely used in the treatment of OA in clinics. However, the molecular mechani...

    Authors: Ping-er Wang, Lei Zhang, Jun Ying, Xing Jin, Cheng Luo, Shibing Xu, Rui Dong, Luwei Xiao, Peijian Tong and Hongting Jin

    Citation: Journal of Translational Medicine 2018 16:72

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  6. Content type: Research

    Ulcerative colitis (UC) is a type of inflammatory bowel disease (IBD) characterized by chronic inflammation of colon. It is commonly believed that the imbalance of immune system and overwhelming production of ...

    Authors: Baoren Zhang, Yi Liu, Xu Lan, Xiaoxi Xu, Xiaoning Zhang, Xiang Li, Yiming Zhao, Guang Li, Caigan Du, Shanzheng Lu and Hao Wang

    Citation: Journal of Translational Medicine 2018 16:71

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  7. Content type: Research

    Periampullary adenocarcinomas, including pancreatic cancer, are a heterogeneous group of tumors with poor prognosis, where classification into intestinal type (I-type) or pancreatobiliary type (PB-type) is a r...

    Authors: Margareta Heby, Sebastian Lundgren, Björn Nodin, Jacob Elebro, Jakob Eberhard and Karin Jirström

    Citation: Journal of Translational Medicine 2018 16:66

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  8. Content type: Research

    Diagnosis of de novo immune hepatitis (dnIH) after liver transplantation relies on biopsy findings, with an abundance of plasma cells (PCs) in the inflammatory infiltrates a hallmark of the disease. Very littl...

    Authors: Elena Aguado-Domínguez, Lourdes Gómez, José Manuel Sousa, Miguel Ángel Gómez-Bravo, Antonio Núñez-Roldán and Isabel Aguilera

    Citation: Journal of Translational Medicine 2018 16:62

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  9. Content type: Research

    MIV-711 is a highly potent and selective cathepsin K inhibitor. The current article summarizes the therapeutic effects of MIV-711 on joint pathology in rabbits subjected to anterior cruciate ligament transecti...

    Authors: Erik Lindström, Biljana Rizoska, Karin Tunblad, Charlotte Edenius, Alison M. Bendele, Don Maul, Michael Larson, Neha Shah, Valerie Yoder Otto, Chris Jerome and Urszula Grabowska

    Citation: Journal of Translational Medicine 2018 16:56

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  10. Content type: Research

    Medical therapeutic options remain quite limited for uterine fibroids treatment. Statins, competitive inhibitors of 3-hydroxy-3-methylglutaryl-coenzyme A reductase, have anti-tumoral effects on multiple cancer...

    Authors: Zhaojun Shen, Saisai Li, Bo Sheng, Qi Shen, Lu-Zhe Sun, Haiyan Zhu and Xueqiong Zhu

    Citation: Journal of Translational Medicine 2018 16:53

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  11. Content type: Research

    The cytokine interleukin-18 was originally identified as an interferon-γ-inducing proinflammatory factor; however, there is increasing evidence to suggest that it has non-immunological effects on physiological...

    Authors: Kyosuke Yamanishi, Keiichiro Mukai, Takuya Hashimoto, Kaoru Ikubo, Keiji Nakasho, Yosif El-Darawish, Wen Li, Daisuke Okuzaki, Yuko Watanabe, Tetsu Hayakawa, Hiroshi Nojima, Hiromichi Yamanishi, Haruki Okamura and Hisato Matsunaga

    Citation: Journal of Translational Medicine 2018 16:51

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  12. Content type: Research

    Acute lymphoblastic leukemia (ALL) is a clonal malignant disorder characterized by an uncontrolled proliferation of immature B or T lymphocytes. Extensive studies have suggested an involvement of angiogenesis ...

    Authors: Manman Deng, Jie Zha, Zhiwu Jiang, Xian Jia, Yuanfei Shi, Peng Li, Xiao Lei Chen, Zhihong Fang, Zhiqiang Du and Bing Xu

    Citation: Journal of Translational Medicine 2018 16:47

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  13. Content type: Research

    Laron syndrome is an autosomal disease resulting from mutations in the growth hormone receptor (GHR) gene. The only therapeutic treatment for Laron syndrome is recombinant insulin-like growth factor I (IGF-I), wh...

    Authors: Honghao Yu, Weihu Long, Xuezeng Zhang, Kaixiang Xu, Jianxiong Guo, Heng Zhao, Honghui Li, Yubo Qing, Weirong Pan, Baoyu Jia, Hong-Ye Zhao, Xingxu Huang and Hong-Jiang Wei

    Citation: Journal of Translational Medicine 2018 16:41

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  14. Content type: Research

    Colorectal cancer (CRC) is one of the most incident cancers, associated with significant morbidity and mortality, and usually classified into three main molecular pathways: chromosomal instability, microsatell...

    Authors: Micaela Freitas, Fábio Ferreira, Sónia Carvalho, Fernanda Silva, Paula Lopes, Luís Antunes, Sofia Salta, Francisca Diniz, Lúcio Lara Santos, José Flávio Videira, Rui Henrique and Carmen Jerónimo

    Citation: Journal of Translational Medicine 2018 16:45

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  15. Content type: Review

    Bronchopulmonary dysplasia (BPD) is the result of a complex process in which several prenatal and/or postnatal factors interfere with lower respiratory tract development, leading to a severe, lifelong disease....

    Authors: Nicola Principi, Giada Maria Di Pietro and Susanna Esposito

    Citation: Journal of Translational Medicine 2018 16:36

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  16. Content type: Research

    Cross-sectional investigations report shorter telomeres in patients with heart failure (HF); however, no studies describe telomere length (TL) trajectory and its relationship with HF progression. Here we aimed...

    Authors: Iris Teubel, Elena Elchinova, Santiago Roura, Marco A. Fernández, Carolina Gálvez-Montón, Pedro Moliner, Marta de Antonio, Josep Lupón and Antoni Bayés-Genís

    Citation: Journal of Translational Medicine 2018 16:35

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  17. Content type: Review

    Organ transplantation remains to be a treatment of choice for patients suffering from irreversible organ failure. Immunosuppressive (IS) drugs employed to maintain the allograft have shown excellent short-term...

    Authors: Urvashi Kaundal, Upma Bagai and Aruna Rakha

    Citation: Journal of Translational Medicine 2018 16:31

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  18. Content type: Research

    Squamous cell carcinoma is the dominant type of esophageal cancer in China with many patients initially diagnosed at advanced stage. Patient-derived xenografts (PDX) models have been developed to be an importa...

    Authors: Jianling Zou, Ying Liu, Jingyuan Wang, Zhentao Liu, Zhihao Lu, Zuhua Chen, Zhongwu Li, Bin Dong, Wenwen Huang, Yanyan Li, Jing Gao and Lin Shen

    Citation: Journal of Translational Medicine 2018 16:15

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  19. Content type: Research

    Dipstick test is widely used to support the diagnosis of urinary tract infections (UTI). It is effective in ruling out UTI, but urine culture is needed for diagnosis confirmation. In this study we compared the...

    Authors: Diana Lelli, Claudio Pedone, Pamela Alemanno, Alessandra Bertini, Claudia Di Gioia, Sara Fazzina, Giorgio Pennazza, Marco Santonico, Simone Grasso, Alessandro Zompanti, Silvia Angeletti and Raffaele Antonelli Incalzi

    Citation: Journal of Translational Medicine 2018 16:17

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  20. Content type: Research

    To analyze the prognostic value of preoperative prognostic nutritional index (PNI) in predicting the survival outcome of hypopharyngeal squamous cell carcinoma (HPSCC) patients receiving radical surgery.

    Authors: Lu-Lu Ye, Ronald Wihal Oei, Fang-Fang Kong, Cheng-Run Du, Rui-Ping Zhai, Qing-Hai Ji, Chao-Su Hu and Hong-Mei Ying

    Citation: Journal of Translational Medicine 2018 16:12

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