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Translational Craniofacial and Dental Medicine

Section edited by Giuseppe Intini

In recent years, several innovations in dental, oral, and craniofacial sciences have been commercialized, transforming clinical practice in the United States and throughout the world. These innovations have been supported by translational research in the fields of tissue regeneration, implantology, biomaterials, computer sciences, informatics, bioinformatics, and genetics. The Translational Craniofacial and Dental Medicine section, by disseminating novel research studies, aims to foster new discoveries in the field of Craniofacial and Dental Medicine.

We are interested in research that investigates innovative approaches in all craniofacial and dental specialties, including oral medicine and oral pathology. We will consider studies regarding therapeutic approaches for treatment of diseases and for tissue regeneration, biomaterials for restorative prosthesis and implantology, diagnostic tools, imaging, and large data analysis. Translational genomics and precision medicine studies that identify novel prognostic markers, tailored interventions, and prophylactic approaches are also welcome.

  1. The aim of the present pilot study was to assess the effectiveness of the platelet-rich fibrin (PRF) apical barrier for the placement of MTA for the treatment of teeth with periapical lesions and open apices.

    Authors: Van-Khoa Pham, Tran-Lan-Khue Pham, An-Tran Pham, Hoang-Lan-Anh Le, Thi-Bich-Van Tran, Kim-Khang Huynh, Nguyen-Minh-Hieu Tran, Thuan-Loc Tran, Minh-Hong Tran, Thi-Anh-Thu Tran, Thi-Tam-Duyen Nguyen and Ngoc-Phuc Nguyen
    Citation: Journal of Translational Medicine 2024 22:498
  2. Progranulin (PGRN), a multifunctional growth factor, plays indispensable roles in the regulation of cancer, inflammation, metabolic diseases, and neurodegenerative diseases. Nevertheless, its immune regulatory...

    Authors: Liguo Zhang, Fujiao Nie, Jingjing Zhao, Shutong Li, Wenchuan Liu, Hongmei Guo and Pishan Yang
    Citation: Journal of Translational Medicine 2024 22:407
  3. Oral inflammatory diseases are localized infectious diseases primarily caused by oral pathogens with the potential for serious systemic complications. However, publicly available datasets for these diseases ar...

    Authors: Weiyin Lin, Hong Yang, Jiayu Lin, Xia Yang, Zhihao Liao, Yifan Zheng, Peng Luo and Chufeng Liu
    Citation: Journal of Translational Medicine 2024 22:282
  4. In recent years, natural bone extracellular matrix (ECM)-inspired materials have found widespread application as scaffolds for bone tissue engineering. However, the challenge of creating scaffolds that mimic n...

    Authors: Yanqing Yang, Huan He, Fang Miao, Mingwei Yu, Xixi Wu, Yuanhang Liu, Jie Fu, Junwei Chen, Liya Ma, Xiangru Chen, Ximing Peng, Zhen You and Chuchao Zhou
    Citation: Journal of Translational Medicine 2024 22:224
  5. One of the main factors for the osseointegration of dental implants is the development of an adequate soft tissue barrier, mainly composed by collagen, which protects the implant from bacterial development. Th...

    Authors: Alessia Belloni, Giulio Argentieri, Giulia Orilisi, Valentina Notarstefano, Elisabetta Giorgini, Gianmaria D’Addazio, Giovanna Orsini, Sergio Caputi and Bruna Sinjari
    Citation: Journal of Translational Medicine 2024 22:120
  6. Periodontitis is a chronic oral inflammatory disease that seriously affects people's quality of life. The purpose of our study was to investigate the correlation between the systemic immune inflammation index ...

    Authors: Junfeng Guo, Rufu Xu, Rongxing Liu, Wenjing Lai, Changpeng Hu, Haitao He, Gang Zhang, Guobing Li, Weiwei Zheng and Rong Zhang
    Citation: Journal of Translational Medicine 2024 22:96
  7. Revascularization and restoration of normal pulp-dentin complex are important for tissue-engineered pulp regeneration. Recently, a unique periodontal tip-like endothelial cells subtype (POTCs) specialized to d...

    Authors: Lingwenyao Kong, Juanjuan Li, Yuwen Bai, Shaoyang Xu, Lin Zhang, Weixian Chen, Lu Gao and Fu Wang
    Citation: Journal of Translational Medicine 2024 22:61
  8. Epigenetic factors influence the odontogenic differentiation of dental pulp stem cells and play indispensable roles during tooth development. Some microRNAs can epigenetically regulate other epigenetic factors...

    Authors: Si Wu, Xin Xu, Shiqi Gao, Sibei Huo, Mian Wan, Xin Zhou, Xuedong Zhou, Liwei Zheng and Yachuan Zhou
    Citation: Journal of Translational Medicine 2024 22:54
  9. Pulp treatment is extremely common in endodontics, with the main purpose of eliminating clinical symptoms and preserving tooth physiological function. However, the effect of dental pulp treatment is closely re...

    Authors: Xinyuan Wang, Yizhi Xiao, Wencheng Song, Lanxiang Ye, Chen Yang, Yuzhen Xing and Zhenglin Yuan
    Citation: Journal of Translational Medicine 2023 21:853
  10. Diabetes mellitus (DM) and periodontitis are two prevalent diseases with mutual influence. Accumulation of advanced glycation end products (AGEs) in hyperglycemia may impair cell function and worsen periodonta...

    Authors: Jie Zhou, Yanlin Zhu, Dongqing Ai, Mengjiao Zhou, Han Li, Guangyue Li, Leilei Zheng and Jinlin Song
    Citation: Journal of Translational Medicine 2023 21:781
  11. Despite the improvements in treatment over the last decades, periodontal disease (PD) affects millions of people around the world and the only treatment available is based on controlling microbial load. Diabet...

    Authors: Vitor C. M. Neves, Luciana Satie Okajima, Eyad Elbahtety, Susan Joseph, James Daly, Athul Menon, Di Fan, Ayste Volkyte, Giuseppe Mainas, Kathy Fung, Pawan Dhami, Andre A. Pelegrine, Paul Sharpe, Luigi Nibali and Mark Ide
    Citation: Journal of Translational Medicine 2023 21:655
  12. Periodontitis is considered as a risk factor for cardiovascular diseases and atherosclerosis. However, the relationship between periodontitis and stroke is rarely studied. Therefore, we aimed to explore the re...

    Authors: Xiaodan Zheng, Xin Li, Juanying Zhen, Dai Xue, Jun Hu, Qing Cao, Aimin Xu, Bernard Man Yung Cheung, Jun Wu and Chao Li
    Citation: Journal of Translational Medicine 2023 21:697
  13. Recent research has established the correlation between gut microbiota and periodontitis via oral-gut axis. Intestinal dysbiosis may play a pivotal bridging role in extra-oral inflammatory comorbidities caused...

    Authors: Xinjian Ye, Bin Liu, Yijing Bai, Yue Cao, Sirui Lin, Linshuoshuo Lyu, Haohao Meng, Yuwei Dai, Ding Ye, Weiyi Pan, Zhiyong Wang, Yingying Mao and Qianming Chen
    Citation: Journal of Translational Medicine 2023 21:674
  14. Restoration of salivary gland function in Sjogren’s syndrome (SS) is still a challenge. Dental pulp stem cells (DPSCs) derived exosomes had shown anti-inflammatory, anti-oxidative, immunomodulatory, and tissue...

    Authors: Shilin Hu, Bo Chen, Jiannan Zhou, Fangqi Liu, Tianjiao Mao, Janak L. Pathak, Nobumoto Watanabe and Jiang Li
    Citation: Journal of Translational Medicine 2023 21:361
  15. Metabolic syndrome (MetS) is a cluster of atherosclerotic risk factors that increases cardiovascular risk. MetS has been associated with periodontitis, but the contribution of single MetS components and any po...

    Authors: Davide Pietropaoli, Serena Altamura, Eleonora Ortu, Luca Guerrini, Theresa T. Pizarro, Claudio Ferri and Rita Del Pinto
    Citation: Journal of Translational Medicine 2023 21:252
  16. Periodontitis is the sixth most prevalent chronic disease globally and places significant burdens on societies and economies worldwide. Behavioral modification, risk factor control, coupled with cause-related ...

    Authors: Jianhan Ren, Melissa Rachel Fok, Yunfan Zhang, Bing Han and Yifan Lin
    Citation: Journal of Translational Medicine 2023 21:149
  17. Periodontal ligament stem cells (PDLSCs) are important seed cells for tissue engineering to realize the regeneration of alveolar bone. Understanding the gene regulatory mechanisms of osteogenic lineage differe...

    Authors: Linglu Jia, Dongfang Li, Ya-Nan Wang, Dongjiao Zhang and Xin Xu
    Citation: Journal of Translational Medicine 2023 21:70
  18. N6-methyladenosine (m6A) is the most prevalent epigenetic modification in eukaryotic messenger RNAs and plays a critical role in cell fate transition. However, it remains to be elucidated how m6A marks functional...

    Authors: Haiyun Luo, Wenjing Liu, Yachuan Zhou, Yanli Zhang, Junrong Wu, Ruolan Wang and Longquan Shao
    Citation: Journal of Translational Medicine 2022 20:605
  19. Periodontitis is a major inflammatory disease of the oral mucosa that is not limited to the oral cavity but also has systemic consequences. Although the importance of chronic periodontitis has been emphasized,...

    Authors: Hansong Lee, Ji-Young Joo, Dong Hyun Sohn, Junho Kang, Yeuni Yu, Hae Ryoun Park and Yun Hak Kim
    Citation: Journal of Translational Medicine 2022 20:504
  20. MicroRNA (miRNA) is accepted as a critical regulator of cell differentiation. However, whether microRNA-223 (miR-223) could affect the osteogenic differentiation of periodontal ligament (PDL)-derived cells is ...

    Authors: Zheng Zhang, Minghui Wang, Youli Zheng, Yanmei Dai, Jiashu Chou, Xiaowei Bian, Pengcheng Wang, Changyi Li and Jing Shen
    Citation: Journal of Translational Medicine 2022 20:465
  21. In the last decades, the ortho-aesthetic-functional rehabilitation had significant advances with the advent of implantology. Despite the success in implantology surgeries, there is a percentage of failures mai...

    Authors: Carlos Henrique Alves, Karolayne Larissa Russi, Natália Conceição Rocha, Fábio Bastos, Michelle Darrieux, Thais Manzano Parisotto and Raquel Girardello
    Citation: Journal of Translational Medicine 2022 20:425
  22. Periodontitis is an inflammatory disease initiated by dysbiosis of the local microbial community. Periodontitis can result in destruction of tooth-supporting tissue; however, overactivation of the host immune ...

    Authors: Hongbing Lin, Huishan Chen, Xuetao Zhao, Tong Ding, Yawei Wang, Zhen Chen, Yue Tian, Peipei Zhang and Yuqin Shen
    Citation: Journal of Translational Medicine 2022 20:279
  23. Sclerostin is the protein product of the SOST gene and is known for its inhibitory effects on bone formation. The monoclonal antibody against sclerostin has been approved as a novel treatment method for osteoporo...

    Authors: Chufang Liao, Shanshan Liang, Yining Wang, Ting Zhong and Xiangning Liu
    Citation: Journal of Translational Medicine 2022 20:221
  24. Extracellular vesicles (EVs) play a key role in constructing a microenvironment that favors the differentiation of stem cells. The present work aimed to determine the molecular mechanisms by which EV derived f...

    Authors: Chaoting Yan, Na Li, Tong Xiao, Xiaying Ye, Lin Fu, Yu Ye, Tao Xu and Jinhua Yu
    Citation: Journal of Translational Medicine 2022 20:208
  25. Emerging evidence shows that periodontal disease (PD) may increase the risk of Coronavirus disease 2019 (COVID-19) complications. Here, we undertook a two-sample Mendelian randomization (MR) study, and investi...

    Authors: Yi Wang, Hui Deng, Yihuai Pan, Lijian Jin, Rongdang Hu, Yongyong Lu, Wenhai Deng, Weijian Sun, Chengshui Chen, Xian Shen and Xiu-Feng Huang
    Citation: Journal of Translational Medicine 2021 19:528

    The Letter to the Editor to this article has been published in Journal of Translational Medicine 2022 20:113

  26. Periodontitis is a chronic inflammatory disease that leads to the destruction of both soft and hard periodontal tissues. Complete periodontal regeneration in clinics using the currently available treatment app...

    Authors: Hongbing Lin, Huishan Chen, Xuetao Zhao, Zhen Chen, Peipei Zhang, Yue Tian, Yawei Wang, Tong Ding, Lijing Wang and Yuqin Shen
    Citation: Journal of Translational Medicine 2021 19:456
  27. Dental implants are considered the gold standard replacement for missing natural teeth. The successful clinical performance of dental implants is due to their ability to osseointegrate with the surrounding bon...

    Authors: Noura M. AlOtaibi, Michael Dunne, Ashraf F. Ayoub and Kurt B. Naudi
    Citation: Journal of Translational Medicine 2021 19:276