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Illnesses of Unknown Etiology

Section Edited by Monica C. Panelli

This section aims to provide a translational medicine forum for the publication of research on illnesses, multisystem diseases and syndromes of unknown etiology. Examples of these include Myalgic Encephalomyelitis (ME)/Chronic Fatigue Syndrome (CFS) and Fibromyalgia Syndrome (FMS).

There has been a continuous albeit undervalued progress in this arena. However, among the many medical specialties that try to diagnose and treat the multiple symptoms presented by patients affected by these diseases, an avenue of rapid and simultaneous communication is missing.

Studies on all aspects of ME/CFS and multi-system diseases of unknown cause with applications in medicine and biotechnology will be considered for publication. The section welcomes contributions that employ traditional clinical, metabolic, epidemiologic, genomics and proteomics methods as diagnostic and prognostic tools.

  1. Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a serious and complex physical illness that affects all body systems with a multiplicity of symptoms, but key hallmarks of the disease are pervasi...

    Authors: Eiren Sweetman, Torsten Kleffmann, Christina Edgar, Michel de Lange, Rosamund Vallings and Warren Tate

    Citation: Journal of Translational Medicine 2020 18:365

    Content type: Research

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  2. Since the 1990s, neuroimaging has been utilised to study Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS), a debilitating illness with unknown aetiology. While brain abnormalities in ME/CFS have bee...

    Authors: Zack Y. Shan, Leighton R. Barnden, Richard A. Kwiatek, Sandeep Bhuta, Daniel F. Hermens and Jim Lagopoulos

    Citation: Journal of Translational Medicine 2020 18:335

    Content type: Review

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  3. Lightheadedness, fatigue, weakness, heart palpitations, cognitive dysfunction, muscle pain, and exercise intolerance are some of the symptoms of orthostatic intolerance (OI). There is substantial comorbidity o...

    Authors: Jihyun Lee, Suzanne D. Vernon, Patricia Jeys, Weam Ali, Andrea Campos, Derya Unutmaz, Brayden Yellman and Lucinda Bateman

    Citation: Journal of Translational Medicine 2020 18:314

    Content type: Research

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  4. Patients with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) or Systemic Exertion Intolerance Disease (SEID) present with a constellation of symptoms including debilitating fatigue that is unrelie...

    Authors: Sean Holden, Rebekah Maksoud, Natalie Eaton-Fitch, Hélène Cabanas, Donald Staines and Sonya Marshall-Gradisnik

    Citation: Journal of Translational Medicine 2020 18:290

    Content type: Review

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  5. Post-exertional malaise (PEM), the cardinal feature of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), occurs generally after exposure to a stressor. It is characterized by the worsening of ME/CFS...

    Authors: Alaa Ghali, Paul Richa, Carole Lacout, Aline Gury, Anne-Berengere Beucher, Chadi Homedan, Christian Lavigne and Geoffrey Urbanski

    Citation: Journal of Translational Medicine 2020 18:246

    Content type: Research

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  6. Most studies to assess effort intolerance in patients with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) have used questionnaires. Few studies have compared questionnaires with objective measures...

    Authors: C. M. C. van Campen, Peter C. Rowe, Freek W. A. Verheugt and Frans C. Visser

    Citation: Journal of Translational Medicine 2020 18:228

    Content type: Research

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  7. Chronic Fatigue Syndrome/Myalgic Encephalomyelitis/Systemic Exertion Intolerance Disease (CFS/ME/SEID) is a complex illness that has an unknown aetiology. It has been proposed that metabolomics may contribute ...

    Authors: Teilah Kathryn Huth, Natalie Eaton-Fitch, Donald Staines and Sonya Marshall-Gradisnik

    Citation: Journal of Translational Medicine 2020 18:198

    Content type: Review

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  8. In myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), altered membrane excitability often occurs in exercising muscles demonstrating muscle dysfunction regardless of any psychiatric disorder. Increas...

    Authors: Yves Jammes, Nabil Adjriou, Nathalie Kipson, Christine Criado, Caroline Charpin, Stanislas Rebaudet, Chloé Stavris, Régis Guieu, Emmanuel Fenouillet and Frédérique Retornaz

    Citation: Journal of Translational Medicine 2020 18:173

    Content type: Research

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  9. Monocytes and toll-like receptors (TLR) have been found in the inflammatory infiltrate of muscle biopsies in patients with idiopathic inflammatory myopathies (IIM), suggesting an important role of these cells ...

    Authors: Jiram Torres-Ruiz, Daniel Alberto Carrillo-Vazquez, Diana Marcela Padilla-Ortiz, Ricardo Vazquez-Rodriguez, Carlos Nuñez-Alvarez, Guillermo Juarez-Vega and Diana Gomez-Martin

    Citation: Journal of Translational Medicine 2020 18:125

    Content type: Research

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  10. Chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME) has been emerging as a significant health issue worldwide. This study aimed to systemically assess the prevalence of CFS/ME in various aspects of analys...

    Authors: Eun-Jin Lim, Yo-Chan Ahn, Eun-Su Jang, Si-Woo Lee, Su-Hwa Lee and Chang-Gue Son

    Citation: Journal of Translational Medicine 2020 18:100

    Content type: Review

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  11. Although medical requirements are urgent, no effective intervention has been proven for chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME). To facilitate the development of new therapeutics, we system...

    Authors: Do-Young Kim, Jin-Seok Lee, Samuel-Young Park, Soo-Jin Kim and Chang-Gue Son

    Citation: Journal of Translational Medicine 2020 18:7

    Content type: Review

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  12. Heart rate variability (HRV) is an objective, non-invasive tool to assessing autonomic dysfunction in chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME). People with CFS/ME tend to have lower HRV; how...

    Authors: Rosa María Escorihuela, Lluís Capdevila, Juan Ramos Castro, María Cleofé Zaragozà, Sara Maurel, José Alegre and Jesús Castro-Marrero

    Citation: Journal of Translational Medicine 2020 18:4

    Content type: Research

    Published on:

  13. Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a debilitating condition characterised by fatigue and post-exertional malaise. Its pathogenesis is poorly understood. GDF15 is a circulating prote...

    Authors: A. Melvin, E. Lacerda, H. M. Dockrell, S. O’Rahilly and L. Nacul

    Citation: Journal of Translational Medicine 2019 17:409

    Content type: Research

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  14. Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is hallmarked by a significant reduction in natural killer (NK) cell cytotoxicity, a mechanism tightly regulated by calcium (Ca2+). Interestingly, inter...

    Authors: Cassandra Balinas, Helene Cabanas, Donald Staines and Sonya Marshall-Gradisnik

    Citation: Journal of Translational Medicine 2019 17:401

    Content type: Research

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  15. Immunoglobulin A nephropathy (IgAN) is the leading cause of end-stage kidney disease. Previous mRNA microarray profiling studies of IgAN revealed inconsistent data. We sought to identify the aberrantly express...

    Authors: Youxia Liu, Xiangchun Liu, Junya Jia, Jie Zheng and Tiekun Yan

    Citation: Journal of Translational Medicine 2019 17:320

    Content type: Research

    Published on:

  16. Chronic fatigue syndrome (CFS) is a heterogeneous disorder with uncertain pathogenesis. Without effective therapy, CFS is characterized by disabling fatigue, depression, memory loss, and somatic discomfort. Th...

    Authors: Tiansong Yang, Yan Yang, Delong Wang, Chaoran Li, Yuanyuan Qu, Jing Guo, Tianyu Shi, Wang Bo, Zhongren Sun and Tetsuya Asakawa

    Citation: Journal of Translational Medicine 2019 17:213

    Content type: Review

    Published on:

  17. Q fever fatigue syndrome (QFS) is a well-documented state of prolonged fatigue following around 20% of acute Q fever infections. It has been hypothesized that low grade inflammation plays a role in its aetiolo...

    Authors: Ruud P. H. Raijmakers, Anne F. M. Jansen, Stephan P. Keijmel, Rob ter Horst, Megan E. Roerink, Boris Novakovic, Leo A. B. Joosten, Jos W. M. van der Meer, Mihai G. Netea and Chantal P. Bleeker-Rovers

    Citation: Journal of Translational Medicine 2019 17:157

    Content type: Research

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  18. Genomic disorders present a wide spectrum of unrelated clinical entities that result from genomic rearrangements. Interstitial insertions requiring three points of breakage are rare genomic rearrangement event...

    Authors: Nuo Si, Xiaolu Meng, Zhen Zhao, Weibo Xia and Xue Zhang

    Citation: Journal of Translational Medicine 2019 17:138

    Content type: Research

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  19. With an increasing indication spectrum of antiresorptive drugs, the medication-related osteonecrosis of the jaw secondary to bisphosphonate therapy [MRONJ (BP)] is continuously gaining clinical relevance. Impa...

    Authors: Falk Wehrhan, Christian Gross, Kay Creutzburg, Kerstin Amann, Jutta Ries, Marco Kesting, Carol-Immanuel Geppert and Manuel Weber

    Citation: Journal of Translational Medicine 2019 17:69

    Content type: Research

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  20. Osteopenia have been well documented in adolescent idiopathic scoliosis (AIS). Adiponectin has been shown to be inversely proportional to body mass index and to affect bone metabolism. However, the circulating...

    Authors: Hong-qi Zhang, Long-jie Wang, Shao-hua Liu, Jiong Li, Li-ge Xiao and Guan-teng Yang

    Citation: Journal of Translational Medicine 2019 17:64

    Content type: Research

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  21. Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a chronic debilitating disease with huge social-economic impact. It has been suggested that immune dysregulation, nitrooxidative stress, and metab...

    Authors: Chin-An Yang, Sandra Bauer, Yu-Chen Ho, Franziska Sotzny, Jan-Gowth Chang and Carmen Scheibenbogen

    Citation: Journal of Translational Medicine 2018 16:231

    Content type: Research

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  22. Mutations in leucine rich repeat kinase 2 (LRRK2) are the most common cause of familial Parkinson’s disease (PD). Mitochondrial and autophagic dysfunction has been described as etiologic factors in different expe...

    Authors: Diana Luz Juárez-Flores, Ingrid González-Casacuberta, Mario Ezquerra, María Bañó, Francesc Carmona-Pontaque, Marc Catalán-García, Mariona Guitart-Mampel, Juan José Rivero, Ester Tobias, Jose Cesar Milisenda, Eduard Tolosa, Maria Jose Marti, Ruben Fernández-Santiago, Francesc Cardellach, Constanza Morén and Glòria Garrabou

    Citation: Journal of Translational Medicine 2018 16:160

    Content type: Research

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  23. Chronic fatigue syndrome (CFS), also known as myalgic encephalomyelitis (ME), is a severely debilitating condition of unknown etiology. The symptoms and risk factors of ME/CFS share features of accelerated agi...

    Authors: Mangalathu S. Rajeevan, Janna Murray, Lisa Oakley, Jin-Mann S. Lin and Elizabeth R. Unger

    Citation: Journal of Translational Medicine 2018 16:44

    Content type: Research

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  24. Candidate-gene studies on fibromyalgia susceptibility often include a small number of single nucleotide polymorphisms (SNPs), which is a limitation. Moreover, there is a paucity of evidence in Europe. Therefor...

    Authors: Fernando Estévez-López, Daniel Camiletti-Moirón, Virginia A. Aparicio, Víctor Segura-Jiménez, Inmaculada C. Álvarez-Gallardo, Alberto Soriano-Maldonado, Milkana Borges-Cosic, Pedro Acosta-Manzano, Rinie Geenen, Manuel Delgado-Fernández, Luis J. Martínez-González, Jonatan R. Ruiz and María J. Álvarez-Cubero

    Citation: Journal of Translational Medicine 2018 16:43

    Content type: Research

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  25. Preliminary evidence suggests that the enteric microbiota may play a role in the expression of neurological symptoms in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). Overlapping symptoms with th...

    Authors: Amy Wallis, Michelle Ball, Henry Butt, Donald P. Lewis, Sandra McKechnie, Phillip Paull, Amber Jaa-Kwee and Dorothy Bruck

    Citation: Journal of Translational Medicine 2018 16:24

    Content type: Research

    Published on:

    The Correction to this article has been published in Journal of Translational Medicine 2018 16:39

  26. Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a potentially disabling disorder. Little is known about the contributors to severe forms of the illness. We describe three consecutive patients wi...

    Authors: Peter C. Rowe, Colleen L. Marden, Scott Heinlein and Charles C. Edwards II

    Citation: Journal of Translational Medicine 2018 16:21

    Content type: Research

    Published on:

  27. Myalgic encephalomyelitis or chronic fatigue syndrome (ME/CFS) is a common and severe disease with a considerable social and economic impact. So far, the etiology is not known, and neither a diagnostic marker ...

    Authors: Carmen Scheibenbogen, Helma Freitag, Julià Blanco, Enrica Capelli, Eliana Lacerda, Jerome Authier, Mira Meeus, Jesus Castro Marrero, Zaiga Nora-Krukle, Elisa Oltra, Elin Bolle Strand, Evelina Shikova, Slobodan Sekulic and Modra Murovska

    Citation: Journal of Translational Medicine 2017 15:162

    Content type: Review

    Published on:

Previously published on the Journal of translational Medicine

Myalgic Encephalomyelitis (ME)/Chronic Fatigue Syndrome (CFS) articles