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Neuroscience

Section edited by Maria Jose Polanco Mora

The Neuroscience section aims to encourage publications that help to reduce the gap between basic preclinical science and medical applications for the patients in the neuroscience field. Any new tool for the dissemination of results in the field can greatly help to progress in the new solutions for the neuropsychiatric patient. The section aims to promote the increase of knowledge on the subject by publishing original research. 

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  1. Myasthenia gravis (MG) and the experimental autoimmune MG (EAMG) animal model are characterized by T-cell-induced and B-cell-dominated autoimmune diseases that affect the neuromuscular junction. Several subtyp...

    Authors: Yong Peng, Huan Yang, Quan Chen, Hong Jin, Ya-hui Xue, Miao-qiao Du, Shu Liu and Shun-yu Yao
    Citation: Journal of Translational Medicine 2024 22:183
  2. Major depressive disorder (MDD) is a common mental illness that affects millions of people worldwide and imposes a heavy burden on individuals, families and society. Previous studies on MDD predominantly focus...

    Authors: Yinping Xie, Lijuan Chen, Leimin Wang, Tongou Liu, Yage Zheng, Lujia Si, Hailong Ge, Hong Xu, Ling Xiao and Gaohua Wang
    Citation: Journal of Translational Medicine 2024 22:109
  3. Parkinson’s disease (PD) is a neurodegenerative disorder characterized by the loss of dopaminergic (DA) neurons in the substantia nigra (SN). Microglia-mediated neuroinflammation has been largely considered on...

    Authors: Danlei Wang, Hongling Gao, Qixiong Qin, Jingyi Li, Jingwei Zhao, Yi Qu, Jiangting Li, Yongjie Xiong, Zhe Min, Zhijuan Mao and Zheng Xue
    Citation: Journal of Translational Medicine 2024 22:63
  4. Rifaximin is a non-reabsorbable antibiotic which acts at gut level, and improves cognition and inflammatory parameters in minimal hepatic encephalopathy (MHE) patients, but not all patients show the same level...

    Authors: Franc Casanova-Ferrer, Juan-José Gallego, Alessandra Fiorillo, Amparo Urios, María-Pilar Ríos, José Luis León, María-Pilar Ballester, Desamparados Escudero-García, Elena Kosenko, Vicente Belloch and Carmina Montoliu
    Citation: Journal of Translational Medicine 2024 22:49
  5. NAD(P)H Quinone Dehydrogenase 1 (NQO1) plays a pivotal role in the regulation of neuronal function and synaptic plasticity, cellular adaptation to oxidative stress, neuroinflammatory and degenerative processes...

    Authors: Li Yuhan, Maryam Khaleghi Ghadiri and Ali Gorji
    Citation: Journal of Translational Medicine 2024 22:4
  6. Neurogenesis is stimulated in the subventricular zone (SVZ) of mice with cortical brain injuries. In most of these injuries, newly generated neuroblasts attempt to migrate toward the injury, accumulating withi...

    Authors: Ricardo Gómez-Oliva, Noelia Geribaldi-Doldán, Samuel Domínguez-García, Ricardo Pardillo-Díaz, Sergio Martínez-Ortega, José M. Oliva-Montero, Patricia Pérez-García, Francisco J. García-Cózar, Juan P. Muñoz-Miranda, Ismael Sánchez-Gomar, Pedro Nunez-Abades and Carmen Castro
    Citation: Journal of Translational Medicine 2023 21:867
  7. Denervation-induced muscle atrophy is complex disease involving multiple biological processes with unknown mechanisms. N6-methyladenosine (m6A) participates in skeletal muscle physiology by regulating multiple...

    Authors: Junjie Sun, Hai Zhou, Zehao Chen, Han Zhang, Yanzhe Cao, Xinlei Yao, Xin Chen, Boya Liu, Zihui Gao, Yuntian Shen, Lei Qi and Hualin Sun
    Citation: Journal of Translational Medicine 2023 21:845
  8. Epilepsy affects over 65 million people worldwide and significantly burdens patients, caregivers, and society. Drug-resistant epilepsy occurs in approximately 30% of patients and growing evidence indicates tha...

    Authors: Sereen Sandouka, Prince Kumar Singh, Aseel Saadi, Rhoda Olowe Taiwo, Yara Sheeni, Taige Zhang, Larin Deeb, Michelle Guignet, Steve H. White and Tawfeeq Shekh-Ahmad
    Citation: Journal of Translational Medicine 2023 21:796
  9. Lycium barbarum polysaccharide (LBP) is an active ingredient extracted from Lycium barbarum that inhibits neuroinflammation, and Lycium barbarum glycopeptide (LbGp) is a glycoprotein with immunological activit...

    Authors: Zhanfeng Jiang, Zhong Zeng, He He, Mei Li, Yuanxiang Lan, Jianwen Hui, Pengfei Bie, Yanjun Chen, Hao Liu, Heng Fan and Hechun Xia
    Citation: Journal of Translational Medicine 2023 21:770
  10. The pathogenesis of Parkinson's disease (PD) has not been fully elucidated, and there are no effective disease-modifying drugs for the treatment of PD. Mesenchymal stem cells have been used to treat several di...

    Authors: Songzhe He, Qiongqiong Wang, Liankuai Chen, Yusheng Jason He, Xiaofang Wang and Shaogang Qu
    Citation: Journal of Translational Medicine 2023 21:747
  11. Maintaining the repair phenotype of denervated Schwann cells in the injured distal nerve is crucial for promoting peripheral nerve regeneration. However, when chronically denervated, the capacity of Schwann ce...

    Authors: Xiong Xu, Lili Song, Yueying Li, Jin Guo, Shuo Huang, Shuang Du, Weizhen Li, Rangjuan Cao and Shusen Cui
    Citation: Journal of Translational Medicine 2023 21:733
  12. Seizures are associated with a decrease in γ-aminobutyric type A acid receptors (GABAaRs) on the neuronal surface, which may be regulated by enhanced internalization of GABAaRs. When interactions between GABAa...

    Authors: Sijun Li, Xing Wei, Hongmi Huang, Lin Ye, Meigang Ma, Lanfeng Sun, Yuling Lu and Yuan Wu
    Citation: Journal of Translational Medicine 2023 21:707
  13. Increasing evidence has linked the thyroid dysfunction to the pathogenesis of dementia. Evidence from clinical studies has demonstrated that hypothyroidism is related to an increased risk of dementia. But the ...

    Authors: Kai Lou, Shudong Liu, Fengxia Zhang, Wenxiu Sun, Xinhuan Su, Wenkai Bi, Qingqing Yin, Yaxin Qiu, Zhenyuan Zhang, Mengzhe Jing and Shizhan Ma
    Citation: Journal of Translational Medicine 2023 21:657
  14. Parkinson's disease (PD), characterized by the progressive loss of dopaminergic neurons in the substantia nigra and striatum of brain, seriously threatens human health, and is still lack of effective treatment...

    Authors: Yan Geng, Xinyi Long, Yuting Zhang, Yupeng Wang, Guoxing You, Wenjie Guo, Gaoming Zhuang, Yuanyuan Zhang, Xiao Cheng, Zhengqiang Yuan and Jie Zan
    Citation: Journal of Translational Medicine 2023 21:652
  15. Alzheimer's disease (AD), Parkinson's disease (PD), and multiple sclerosis (MS) are three nervous system diseases that partially overlap clinically and genetically. However, bulk RNA-sequencing did not accurat...

    Authors: Li-Yuan Fan, Jing Yang, Ruo-Yu Liu, Ying Kong, Guang-Yu Guo and Yu-Ming Xu
    Citation: Journal of Translational Medicine 2023 21:649
  16. Poor medication adherence contributes to increased morbidity and mortality in patients with epilepsy and may be under-addressed in clinical practice. Ethical concerns make it impossible to study the impact of ...

    Authors: Michelle Guignet, Amanda Campbell, Jonathan Vuong, Dale Whittington and H. Steve White
    Citation: Journal of Translational Medicine 2023 21:642
  17. The nucleotide-binding oligomeric domain (NOD)-like receptor protein 3 (NLRP3) inflammasome is believed to be a key mediator of neuroinflammation and subsequent secondary brain injury induced by ischemic strok...

    Authors: Yuxin Chen, Xiaohuan Li, Qian Xiong, Yehong Du, Man Luo, Lilin Yi, Yayan Pang, Xiuyu Shi, Yu Tian Wang and Zhifang Dong
    Citation: Journal of Translational Medicine 2023 21:567
  18. Intracerebral hemorrhage (ICH) is a condition associated with high morbidity and mortality, and glia-mediated inflammation is a major contributor to neurological deficits. However, there is currently no proven...

    Authors: Wei-Shen Su, Chun-Hu Wu, Wen-Shin Song, Szu-Fu Chen and Feng-Yi Yang
    Citation: Journal of Translational Medicine 2023 21:565
  19. Myasthenia gravis (MG) is the most prevalent autoimmune disorder affecting the neuromuscular junction. A rapid deterioration in respiratory muscle can lead to a myasthenic crisis (MC), which represents a life-...

    Authors: Huahua Zhong, Xiao Huan, Rui Zhao, Manqiqige Su, Chong Yan, Jie Song, Jianying Xi, Chongbo Zhao, Feifei Luo and Sushan Luo
    Citation: Journal of Translational Medicine 2023 21:564
  20. Brachial plexus root avulsion (BPRA), a disabling peripheral nerve injury, induces substantial motoneuron death, motor axon degeneration and denervation of biceps muscles, leading to the loss of upper limb mot...

    Authors: Lin Wu, Shuangxi Chen, Bing He, Guijuan Zhou, Yan Xu, Guanghua Zhu, Juan Xie, Limin Deng, Xuanwei Wen, Sijing Li and Zijian Xiao
    Citation: Journal of Translational Medicine 2023 21:563
  21. Preinjury of peripheral nerves triggers dorsal root ganglia (DRG) axon regeneration, a biological change that is more pronounced in young mice than in old mice, but the complex mechanism has not been clearly e...

    Authors: Xiaoxiong Wang, Wenxiang Li, Jianping Zhang, Jinze Li, Xianjin Zhang, Min Wang, Zhijian Wei and Shiqing Feng
    Citation: Journal of Translational Medicine 2023 21:511
  22. Duchenne muscular dystrophy (DMD) is an X-linked, incurable, degenerative neuromuscular disease that is exacerbated by secondary inflammation. N6-methyladenosine (m6A), the most common base modification of RNA, h...

    Authors: Xu Han, Guang Ji, Ning Wang, Le Yi, Yafei Mao, Jinliang Deng, Hongran Wu, Shaojuan Ma, Jingzhe Han, Yi Bu, Pingping Fang, Juyi Liu, Fanzhe Sun and Xueqin Song
    Citation: Journal of Translational Medicine 2023 21:459
  23. Despite advances in pharmacology, the treatment of schizophrenia (SZ) remains a challenge due to relapse after antipsychotic discontinuation and multiple adverse effects of antipsychotics. We hypothesized that...

    Authors: Xiaoe Lang, Mei Xue, Xiaocui Zang, Fengchun Wu, Meihong Xiu and Xiangyang Zhang
    Citation: Journal of Translational Medicine 2023 21:432
  24. Heterozygous loss-of-function mutations in the progranulin (PGRN) gene (GRN) cause a reduction in PGRN and lead to the development of frontotemporal dementia (FTD-GRN). PGRN is a secreted lysosomal chaperone, imm...

    Authors: Michael Kurnellas, Ananya Mitra, Tina Schwabe, Robert Paul, Andrew E. Arrant, Erik D. Roberson, Michael Ward, Felix Yeh, Hua Long and Arnon Rosenthal
    Citation: Journal of Translational Medicine 2023 21:387
  25. The cerebellum plays key roles in the pathology of multiple sclerosis (MS) and neuromyelitis optica spectrum disorder (NMOSD), but the way in which these conditions affect how the cerebellum communicates with ...

    Authors: Yuping Yang, Junle Li, Ting Li, Zhen Li, Zhizheng Zhuo, Xuemei Han, Yunyun Duan, Guanmei Cao, Fenglian Zheng, Decai Tian, Xinli Wang, Xinghu Zhang, Kuncheng Li, Fuqing Zhou, Muhua Huang, Yuxin Li…
    Citation: Journal of Translational Medicine 2023 21:352
  26. Despite numerous clinical trials and decades of endeavour, there is still no effective cure for Alzheimer's disease. Computational drug repositioning approaches may be employed for the development of new treat...

    Authors: Abdulahad Bayraktar, Xiangyu Li, Woonghee Kim, Cheng Zhang, Hasan Turkez, Saeed Shoaie and Adil Mardinoglu
    Citation: Journal of Translational Medicine 2023 21:332
  27. Auditory neuropathy is an unusual type of hearing loss. At least 40% of patients with this disease have underlying genetic causes. However, in many hereditary auditory neuropathy cases, etiology remains undete...

    Authors: Kaitian Chen, Changwu Li, Chang Dong, Xiaoqing Cen, Yueying Wang, Yue Liang, Yuanping Zhu, Shubin Fang and Hongyan Jiang
    Citation: Journal of Translational Medicine 2023 21:279
  28. Alzheimer’s disease (AD) is characterized by a progressive loss of memory that cannot be efficiently managed by currently available AD therapeutics. So far, most treatments for AD that have the potential to im...

    Authors: Connor M Wander, Ya-Dong Li, Hechen Bao, Brent Asrican, Yan-Jia Luo, Heather A Sullivan, Tzu-Hao Harry Chao, Wei-Ting Zhang, Samantha L Chéry, Dalton S Tart, Ze-Ka Chen, Yen-Yu Ian Shih, Ian R Wickersham, Todd J Cohen and Juan Song
    Citation: Journal of Translational Medicine 2023 21:258
  29. Owing to metabolic disequilibrium and immune suppression, intracerebral hemorrhage (ICH) patients are prone to infections; according to a recent global analysis of stroke cases, approximately 10 million new-on...

    Authors: Jie Lin, Ya Xu, Peiwen Guo, Yù-Jié Chen, Jiru Zhou, Min Xia, Binbin Tan, Xin Liu, Hua Feng and Yujie Chen
    Citation: Journal of Translational Medicine 2023 21:196
  30. Clinically, Charcot-Marie-Tooth disease (CMT)-associated muscle atrophy still lacks effective treatment. Deletion and mutation of L-periaxin can be involved in CMT type 4F (CMT4F) by destroying the myelin shea...

    Authors: Ruo-nan Zhang, Xin Bao, Yun Liu, Yan Wang, Xing-Yuan Li, Ge Tan, Magdaleena Naemi Mbadhi, Wei Xu, Qian Yang, Lu-yuan Yao, Long Chen, Xiao-ying Zhao, Chang-qing Hu, Jing-xuan Zhang, Hong-tao Zheng, Yan Wu…
    Citation: Journal of Translational Medicine 2023 21:173
  31. The left dorsolateral prefrontal cortex (DLPFC) is involved in early-phase manual dexterity skill acquisition when cognitive control processes, such as integration and complexity demands, are required. However...

    Authors: Akihiro Watanabe, Daisuke Sawamura, Hisato Nakazono, Yukina Tokikuni, Hiroshi Miura, Kazuhiro Sugawara, Kanako Fuyama, Harukazu Tohyama, Susumu Yoshida and Shinya Sakai
    Citation: Journal of Translational Medicine 2023 21:143
  32. Exercise-related signaling Fndc5/irisin expresses in brain and acts as a crucial regulator of cognitive function, but its detailed roles in vascular dementia (VaD) are still unclear. Low intensity pulsed ultra...

    Authors: Degang Song, Xiaomin Chen, Na Zhou, Yi Yuan, Shuo Geng, Cong Zhang, Zhe Zhao, Xingran Wang, Xinran Bao, Xifa Lan and Xiangjian Zhang
    Citation: Journal of Translational Medicine 2023 21:139
  33. Cognitive function is an important ability of the brain, but cognitive dysfunction can easily develop once the brain is injured in various neuropathological conditions or diseases. Photobiomodulation therapy i...

    Authors: Wei-tong Pan, Pan-miao Liu, Daqing Ma and Jian-jun Yang
    Citation: Journal of Translational Medicine 2023 21:135
  34. Patients suffering from chronic pain often also exhibit depression symptoms. Soluble epoxide hydrolase (sEH) inhibitors can decrease blood levels of inflammatory cytokines. However, whether inhibiting sEH sign...

    Authors: Ailin Luo, Zifeng Wu, Shan Li, Cindy B. McReynolds, Di Wang, Hanyu Liu, Chaoli Huang, Teng He, Xinying Zhang, Yuanyuan Wang, Cunming Liu, Bruce D. Hammock, Kenji Hashimoto and Chun Yang
    Citation: Journal of Translational Medicine 2023 21:71
  35. Substantial evidence suggests that hypertension is a significant risk factor for cognitive decline. However, it is unclear whether the genetic predisposition to hypertension is also associated with cellular dy...

    Authors: Moti Ben-Shabat, Yaseen Awad-Igbaria, Shifra Sela, Bella Gross, Yoram Yagil, Chana Yagil and Eilam Palzur
    Citation: Journal of Translational Medicine 2023 21:51
  36. Non-battle related musculoskeletal injuries (MSKI) are one of the primary medical issues diminishing Service member medical readiness. The MSKI problem is challenging because it is difficult to assess all of t...

    Authors: Courtney M. Butowicz, Brad D. Hendershot, Nora L. Watson, Daniel I. Brooks, Donald L. Goss, Robert A. Whitehurst, Alisha D. Harvey, Matthew S. Helton, Joseph R. Kardouni, Matthew B. Garber and Timothy C. Mauntel
    Citation: Journal of Translational Medicine 2022 20:619
  37. The subclassification of prolonged disorders of consciousness (DoC) based on sleep patterns is important for the evaluation and treatment of the disease. This study evaluates the correlation between polysomnog...

    Authors: Jie Yu, Yuehao Wu, Biwen Wu, Chuan Xu, Jiaye Cai, Xinrui Wen, Fanxia Meng, Li Zhang, Fangping He, Lirong Hong, Jian Gao, Jingqi Li, Jintai Yu and Benyan Luo
    Citation: Journal of Translational Medicine 2022 20:601
  38. Myotonic dystrophy type 1 (DM1), one of the most common forms of adult-onset muscular dystrophy, is caused by abnormally expanded CTG repeats in the 3′ untranslated region of the DMPK gene. The CUG repeats transc...

    Authors: Kun Huang, Dan-Dan Wang, Wen-Bao Hu, Wei-Qian Zeng, Xia Xu, Qiu-Xiang Li, Fang-Fang Bi, Huan Yang and Jian Qiu
    Citation: Journal of Translational Medicine 2022 20:588
  39. Until now, the treatment of patients with autism spectrum disorder (ASD) remain a difficult problem. The insula is involved in empathy and sensorimotor integration, which are often impaired in individuals with...

    Authors: Lifei Xiao, Shucai Jiang, Yangyang Wang, Caibin Gao, Cuicui Liu, Xianhao Huo, Wenchao Li, Baorui Guo, Chaofan Wang, Yu Sun, Anni Wang, Yan Feng, Feng Wang and Tao Sun
    Citation: Journal of Translational Medicine 2022 20:570
  40. Although lipid metabolite dysfunction contributes substantially to clinical signs and pathophysiology of Alzheimer’s disease (AD), how dyslipidemia promoting neuropathological processes and brain functional im...

    Authors: Qing Wang, Feifei Zang, Cancan He, Zhijun Zhang and Chunming Xie
    Citation: Journal of Translational Medicine 2022 20:567
  41. The development of permanent disability in multiple sclerosis (MS) is highly variable among patients, and the exact mechanisms that contribute to this disability remain unknown.

    Authors: Marlene Tahedl, Seth M. Levine, Robert Weissert, Zacharias Kohl, De-Hyung Lee, Ralf A. Linker and Jens V. Schwarzbach
    Citation: Journal of Translational Medicine 2022 20:488
  42. Although anxiety disorders are one of the most prevalent mental disorders, their underlying biological mechanisms have not yet been fully elucidated. In recent years, genetically determined metabolites (GDMs) ...

    Authors: Gui Xiao, Qingnan He, Li Liu, Tingting Zhang, Mengjia Zhou, Xingxing Li, Yijun Chen, Yanyi Chen and Chunxiang Qin
    Citation: Journal of Translational Medicine 2022 20:475
  43. Metabolic disturbance has been reported in patients with epilepsy. Still, the evidence about the causal role of metabolites in facilitating or preventing epilepsy is lacking. Systematically investigating the c...

    Authors: Jiahao Cai, Xiaoyu Li, Shangbin Wu, Yang Tian, Yani Zhang, Zixin Wei, Zixiang Jin, Xiaojing Li, Xiong Chen and Wen-Xiong Chen
    Citation: Journal of Translational Medicine 2022 20:437
  44. Neuroligins are postsynaptic cell adhesion molecules that are relevant to many neurodevelopmental disorders. They are differentially enriched at the postsynapse and interact with their presynaptic ligands, neu...

    Authors: Xing Liu, Fuzhou Hua, Danying Yang, Yue Lin, Lieliang Zhang, Jun Ying, Hongguang Sheng and Xifeng Wang
    Citation: Journal of Translational Medicine 2022 20:418
  45. Glucocorticoid signalling is closely related to both epilepsy and associated cognitive impairment, possibly through mechanisms involving neuronal apoptosis. As a critical enzyme for glucocorticoid action, the ...

    Authors: Xueying Li, Wanhua Qiu, Lu Deng, Jingjing Lin, Wenting Huang, Yuchen Xu, Mulan Zhang, Nigel C. Jones, Runxuan Lin, Huiqin Xu, Li Lin, Peijun Li and Xinshi Wang
    Citation: Journal of Translational Medicine 2022 20:406
  46. With the advent of an aging society, the incidence of dementia is increasing, resulting in a vast burden on society. It is increasingly acknowledged that neuroinflammation is implicated in various neurological...

    Authors: Xiuqin Rao, Fuzhou Hua, Lieliang Zhang, Yue Lin, Pu Fang, Shoulin Chen, Jun Ying and Xifeng Wang
    Citation: Journal of Translational Medicine 2022 20:369
  47. Zishen Pingchan granule (ZPG), a traditional Chinese herbal recipe for treating Parkinson’s disease (PD), is usually used as an add-on drug with some antiparkinsonian drugs in China. The objectives of this stu...

    Authors: Houxu Ning, Hao Zhou, Jingru Ren, Gaiyan Zhou, Ning Yang, Zhenfu Wang, Canxing Yuan, Zuojun Tian, Juping Chen, Lihua Shen, Huifen Zheng, Yang Zhao, Haidong Wang, Weiguo Liu and Zhenguo Liu
    Citation: Journal of Translational Medicine 2022 20:357

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