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Section edited by Maria Jose Polanco Mora

The Neuroscience section aims to encourage publications that help to reduce the gap between basic preclinical science and medical applications for the patients in the neuroscience field. Any new tool for the dissemination of results in the field can greatly help to progress in the new solutions for the neuropsychiatric patient. The section aims to promote the increase of knowledge on the subject by publishing original research. 

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  1. Increasing evidence has linked the thyroid dysfunction to the pathogenesis of dementia. Evidence from clinical studies has demonstrated that hypothyroidism is related to an increased risk of dementia. But the ...

    Authors: Kai Lou, Shudong Liu, Fengxia Zhang, Wenxiu Sun, Xinhuan Su, Wenkai Bi, Qingqing Yin, Yaxin Qiu, Zhenyuan Zhang, Mengzhe Jing and Shizhan Ma
    Citation: Journal of Translational Medicine 2023 21:657
  2. Parkinson's disease (PD), characterized by the progressive loss of dopaminergic neurons in the substantia nigra and striatum of brain, seriously threatens human health, and is still lack of effective treatment...

    Authors: Yan Geng, Xinyi Long, Yuting Zhang, Yupeng Wang, Guoxing You, Wenjie Guo, Gaoming Zhuang, Yuanyuan Zhang, Xiao Cheng, Zhengqiang Yuan and Jie Zan
    Citation: Journal of Translational Medicine 2023 21:652
  3. Alzheimer's disease (AD), Parkinson's disease (PD), and multiple sclerosis (MS) are three nervous system diseases that partially overlap clinically and genetically. However, bulk RNA-sequencing did not accurat...

    Authors: Li-Yuan Fan, Jing Yang, Ruo-Yu Liu, Ying Kong, Guang-Yu Guo and Yu-Ming Xu
    Citation: Journal of Translational Medicine 2023 21:649
  4. Poor medication adherence contributes to increased morbidity and mortality in patients with epilepsy and may be under-addressed in clinical practice. Ethical concerns make it impossible to study the impact of ...

    Authors: Michelle Guignet, Amanda Campbell, Jonathan Vuong, Dale Whittington and H. Steve White
    Citation: Journal of Translational Medicine 2023 21:642
  5. The nucleotide-binding oligomeric domain (NOD)-like receptor protein 3 (NLRP3) inflammasome is believed to be a key mediator of neuroinflammation and subsequent secondary brain injury induced by ischemic strok...

    Authors: Yuxin Chen, Xiaohuan Li, Qian Xiong, Yehong Du, Man Luo, Lilin Yi, Yayan Pang, Xiuyu Shi, Yu Tian Wang and Zhifang Dong
    Citation: Journal of Translational Medicine 2023 21:567
  6. Intracerebral hemorrhage (ICH) is a condition associated with high morbidity and mortality, and glia-mediated inflammation is a major contributor to neurological deficits. However, there is currently no proven...

    Authors: Wei-Shen Su, Chun-Hu Wu, Wen-Shin Song, Szu-Fu Chen and Feng-Yi Yang
    Citation: Journal of Translational Medicine 2023 21:565
  7. Myasthenia gravis (MG) is the most prevalent autoimmune disorder affecting the neuromuscular junction. A rapid deterioration in respiratory muscle can lead to a myasthenic crisis (MC), which represents a life-...

    Authors: Huahua Zhong, Xiao Huan, Rui Zhao, Manqiqige Su, Chong Yan, Jie Song, Jianying Xi, Chongbo Zhao, Feifei Luo and Sushan Luo
    Citation: Journal of Translational Medicine 2023 21:564
  8. Brachial plexus root avulsion (BPRA), a disabling peripheral nerve injury, induces substantial motoneuron death, motor axon degeneration and denervation of biceps muscles, leading to the loss of upper limb mot...

    Authors: Lin Wu, Shuangxi Chen, Bing He, Guijuan Zhou, Yan Xu, Guanghua Zhu, Juan Xie, Limin Deng, Xuanwei Wen, Sijing Li and Zijian Xiao
    Citation: Journal of Translational Medicine 2023 21:563
  9. Preinjury of peripheral nerves triggers dorsal root ganglia (DRG) axon regeneration, a biological change that is more pronounced in young mice than in old mice, but the complex mechanism has not been clearly e...

    Authors: Xiaoxiong Wang, Wenxiang Li, Jianping Zhang, Jinze Li, Xianjin Zhang, Min Wang, Zhijian Wei and Shiqing Feng
    Citation: Journal of Translational Medicine 2023 21:511
  10. Duchenne muscular dystrophy (DMD) is an X-linked, incurable, degenerative neuromuscular disease that is exacerbated by secondary inflammation. N6-methyladenosine (m6A), the most common base modification of RNA, h...

    Authors: Xu Han, Guang Ji, Ning Wang, Le Yi, Yafei Mao, Jinliang Deng, Hongran Wu, Shaojuan Ma, Jingzhe Han, Yi Bu, Pingping Fang, Juyi Liu, Fanzhe Sun and Xueqin Song
    Citation: Journal of Translational Medicine 2023 21:459
  11. Despite advances in pharmacology, the treatment of schizophrenia (SZ) remains a challenge due to relapse after antipsychotic discontinuation and multiple adverse effects of antipsychotics. We hypothesized that...

    Authors: Xiaoe Lang, Mei Xue, Xiaocui Zang, Fengchun Wu, Meihong Xiu and Xiangyang Zhang
    Citation: Journal of Translational Medicine 2023 21:432
  12. Heterozygous loss-of-function mutations in the progranulin (PGRN) gene (GRN) cause a reduction in PGRN and lead to the development of frontotemporal dementia (FTD-GRN). PGRN is a secreted lysosomal chaperone, imm...

    Authors: Michael Kurnellas, Ananya Mitra, Tina Schwabe, Robert Paul, Andrew E. Arrant, Erik D. Roberson, Michael Ward, Felix Yeh, Hua Long and Arnon Rosenthal
    Citation: Journal of Translational Medicine 2023 21:387
  13. The cerebellum plays key roles in the pathology of multiple sclerosis (MS) and neuromyelitis optica spectrum disorder (NMOSD), but the way in which these conditions affect how the cerebellum communicates with ...

    Authors: Yuping Yang, Junle Li, Ting Li, Zhen Li, Zhizheng Zhuo, Xuemei Han, Yunyun Duan, Guanmei Cao, Fenglian Zheng, Decai Tian, Xinli Wang, Xinghu Zhang, Kuncheng Li, Fuqing Zhou, Muhua Huang, Yuxin Li…
    Citation: Journal of Translational Medicine 2023 21:352
  14. Despite numerous clinical trials and decades of endeavour, there is still no effective cure for Alzheimer's disease. Computational drug repositioning approaches may be employed for the development of new treat...

    Authors: Abdulahad Bayraktar, Xiangyu Li, Woonghee Kim, Cheng Zhang, Hasan Turkez, Saeed Shoaie and Adil Mardinoglu
    Citation: Journal of Translational Medicine 2023 21:332
  15. Auditory neuropathy is an unusual type of hearing loss. At least 40% of patients with this disease have underlying genetic causes. However, in many hereditary auditory neuropathy cases, etiology remains undete...

    Authors: Kaitian Chen, Changwu Li, Chang Dong, Xiaoqing Cen, Yueying Wang, Yue Liang, Yuanping Zhu, Shubin Fang and Hongyan Jiang
    Citation: Journal of Translational Medicine 2023 21:279
  16. Alzheimer’s disease (AD) is characterized by a progressive loss of memory that cannot be efficiently managed by currently available AD therapeutics. So far, most treatments for AD that have the potential to im...

    Authors: Connor M Wander, Ya-Dong Li, Hechen Bao, Brent Asrican, Yan-Jia Luo, Heather A Sullivan, Tzu-Hao Harry Chao, Wei-Ting Zhang, Samantha L Chéry, Dalton S Tart, Ze-Ka Chen, Yen-Yu Ian Shih, Ian R Wickersham, Todd J Cohen and Juan Song
    Citation: Journal of Translational Medicine 2023 21:258
  17. Owing to metabolic disequilibrium and immune suppression, intracerebral hemorrhage (ICH) patients are prone to infections; according to a recent global analysis of stroke cases, approximately 10 million new-on...

    Authors: Jie Lin, Ya Xu, Peiwen Guo, Yù-Jié Chen, Jiru Zhou, Min Xia, Binbin Tan, Xin Liu, Hua Feng and Yujie Chen
    Citation: Journal of Translational Medicine 2023 21:196
  18. Clinically, Charcot-Marie-Tooth disease (CMT)-associated muscle atrophy still lacks effective treatment. Deletion and mutation of L-periaxin can be involved in CMT type 4F (CMT4F) by destroying the myelin shea...

    Authors: Ruo-nan Zhang, Xin Bao, Yun Liu, Yan Wang, Xing-Yuan Li, Ge Tan, Magdaleena Naemi Mbadhi, Wei Xu, Qian Yang, Lu-yuan Yao, Long Chen, Xiao-ying Zhao, Chang-qing Hu, Jing-xuan Zhang, Hong-tao Zheng, Yan Wu…
    Citation: Journal of Translational Medicine 2023 21:173
  19. The left dorsolateral prefrontal cortex (DLPFC) is involved in early-phase manual dexterity skill acquisition when cognitive control processes, such as integration and complexity demands, are required. However...

    Authors: Akihiro Watanabe, Daisuke Sawamura, Hisato Nakazono, Yukina Tokikuni, Hiroshi Miura, Kazuhiro Sugawara, Kanako Fuyama, Harukazu Tohyama, Susumu Yoshida and Shinya Sakai
    Citation: Journal of Translational Medicine 2023 21:143
  20. Exercise-related signaling Fndc5/irisin expresses in brain and acts as a crucial regulator of cognitive function, but its detailed roles in vascular dementia (VaD) are still unclear. Low intensity pulsed ultra...

    Authors: Degang Song, Xiaomin Chen, Na Zhou, Yi Yuan, Shuo Geng, Cong Zhang, Zhe Zhao, Xingran Wang, Xinran Bao, Xifa Lan and Xiangjian Zhang
    Citation: Journal of Translational Medicine 2023 21:139
  21. Cognitive function is an important ability of the brain, but cognitive dysfunction can easily develop once the brain is injured in various neuropathological conditions or diseases. Photobiomodulation therapy i...

    Authors: Wei-tong Pan, Pan-miao Liu, Daqing Ma and Jian-jun Yang
    Citation: Journal of Translational Medicine 2023 21:135
  22. Patients suffering from chronic pain often also exhibit depression symptoms. Soluble epoxide hydrolase (sEH) inhibitors can decrease blood levels of inflammatory cytokines. However, whether inhibiting sEH sign...

    Authors: Ailin Luo, Zifeng Wu, Shan Li, Cindy B. McReynolds, Di Wang, Hanyu Liu, Chaoli Huang, Teng He, Xinying Zhang, Yuanyuan Wang, Cunming Liu, Bruce D. Hammock, Kenji Hashimoto and Chun Yang
    Citation: Journal of Translational Medicine 2023 21:71
  23. Substantial evidence suggests that hypertension is a significant risk factor for cognitive decline. However, it is unclear whether the genetic predisposition to hypertension is also associated with cellular dy...

    Authors: Moti Ben-Shabat, Yaseen Awad-Igbaria, Shifra Sela, Bella Gross, Yoram Yagil, Chana Yagil and Eilam Palzur
    Citation: Journal of Translational Medicine 2023 21:51
  24. Non-battle related musculoskeletal injuries (MSKI) are one of the primary medical issues diminishing Service member medical readiness. The MSKI problem is challenging because it is difficult to assess all of t...

    Authors: Courtney M. Butowicz, Brad D. Hendershot, Nora L. Watson, Daniel I. Brooks, Donald L. Goss, Robert A. Whitehurst, Alisha D. Harvey, Matthew S. Helton, Joseph R. Kardouni, Matthew B. Garber and Timothy C. Mauntel
    Citation: Journal of Translational Medicine 2022 20:619
  25. The subclassification of prolonged disorders of consciousness (DoC) based on sleep patterns is important for the evaluation and treatment of the disease. This study evaluates the correlation between polysomnog...

    Authors: Jie Yu, Yuehao Wu, Biwen Wu, Chuan Xu, Jiaye Cai, Xinrui Wen, Fanxia Meng, Li Zhang, Fangping He, Lirong Hong, Jian Gao, Jingqi Li, Jintai Yu and Benyan Luo
    Citation: Journal of Translational Medicine 2022 20:601
  26. Myotonic dystrophy type 1 (DM1), one of the most common forms of adult-onset muscular dystrophy, is caused by abnormally expanded CTG repeats in the 3′ untranslated region of the DMPK gene. The CUG repeats transc...

    Authors: Kun Huang, Dan-Dan Wang, Wen-Bao Hu, Wei-Qian Zeng, Xia Xu, Qiu-Xiang Li, Fang-Fang Bi, Huan Yang and Jian Qiu
    Citation: Journal of Translational Medicine 2022 20:588
  27. Until now, the treatment of patients with autism spectrum disorder (ASD) remain a difficult problem. The insula is involved in empathy and sensorimotor integration, which are often impaired in individuals with...

    Authors: Lifei Xiao, Shucai Jiang, Yangyang Wang, Caibin Gao, Cuicui Liu, Xianhao Huo, Wenchao Li, Baorui Guo, Chaofan Wang, Yu Sun, Anni Wang, Yan Feng, Feng Wang and Tao Sun
    Citation: Journal of Translational Medicine 2022 20:570
  28. Although lipid metabolite dysfunction contributes substantially to clinical signs and pathophysiology of Alzheimer’s disease (AD), how dyslipidemia promoting neuropathological processes and brain functional im...

    Authors: Qing Wang, Feifei Zang, Cancan He, Zhijun Zhang and Chunming Xie
    Citation: Journal of Translational Medicine 2022 20:567
  29. The development of permanent disability in multiple sclerosis (MS) is highly variable among patients, and the exact mechanisms that contribute to this disability remain unknown.

    Authors: Marlene Tahedl, Seth M. Levine, Robert Weissert, Zacharias Kohl, De-Hyung Lee, Ralf A. Linker and Jens V. Schwarzbach
    Citation: Journal of Translational Medicine 2022 20:488
  30. Although anxiety disorders are one of the most prevalent mental disorders, their underlying biological mechanisms have not yet been fully elucidated. In recent years, genetically determined metabolites (GDMs) ...

    Authors: Gui Xiao, Qingnan He, Li Liu, Tingting Zhang, Mengjia Zhou, Xingxing Li, Yijun Chen, Yanyi Chen and Chunxiang Qin
    Citation: Journal of Translational Medicine 2022 20:475
  31. Metabolic disturbance has been reported in patients with epilepsy. Still, the evidence about the causal role of metabolites in facilitating or preventing epilepsy is lacking. Systematically investigating the c...

    Authors: Jiahao Cai, Xiaoyu Li, Shangbin Wu, Yang Tian, Yani Zhang, Zixin Wei, Zixiang Jin, Xiaojing Li, Xiong Chen and Wen-Xiong Chen
    Citation: Journal of Translational Medicine 2022 20:437
  32. Neuroligins are postsynaptic cell adhesion molecules that are relevant to many neurodevelopmental disorders. They are differentially enriched at the postsynapse and interact with their presynaptic ligands, neu...

    Authors: Xing Liu, Fuzhou Hua, Danying Yang, Yue Lin, Lieliang Zhang, Jun Ying, Hongguang Sheng and Xifeng Wang
    Citation: Journal of Translational Medicine 2022 20:418
  33. Glucocorticoid signalling is closely related to both epilepsy and associated cognitive impairment, possibly through mechanisms involving neuronal apoptosis. As a critical enzyme for glucocorticoid action, the ...

    Authors: Xueying Li, Wanhua Qiu, Lu Deng, Jingjing Lin, Wenting Huang, Yuchen Xu, Mulan Zhang, Nigel C. Jones, Runxuan Lin, Huiqin Xu, Li Lin, Peijun Li and Xinshi Wang
    Citation: Journal of Translational Medicine 2022 20:406
  34. With the advent of an aging society, the incidence of dementia is increasing, resulting in a vast burden on society. It is increasingly acknowledged that neuroinflammation is implicated in various neurological...

    Authors: Xiuqin Rao, Fuzhou Hua, Lieliang Zhang, Yue Lin, Pu Fang, Shoulin Chen, Jun Ying and Xifeng Wang
    Citation: Journal of Translational Medicine 2022 20:369
  35. Zishen Pingchan granule (ZPG), a traditional Chinese herbal recipe for treating Parkinson’s disease (PD), is usually used as an add-on drug with some antiparkinsonian drugs in China. The objectives of this stu...

    Authors: Houxu Ning, Hao Zhou, Jingru Ren, Gaiyan Zhou, Ning Yang, Zhenfu Wang, Canxing Yuan, Zuojun Tian, Juping Chen, Lihua Shen, Huifen Zheng, Yang Zhao, Haidong Wang, Weiguo Liu and Zhenguo Liu
    Citation: Journal of Translational Medicine 2022 20:357
  36. In polyglutamine (polyQ) diseases, the identification of modifiers and the construction of prediction model for progression facilitate genetic counseling, clinical management and therapeutic interventions.

    Authors: Linliu Peng, Yun Peng, Zhao Chen, Chunrong Wang, Zhe Long, Huirong Peng, Yuting Shi, Lu Shen, Kun Xia, Vanessa B. Leotti, Laura Bannach Jardim, Beisha Tang, Rong Qiu and Hong Jiang
    Citation: Journal of Translational Medicine 2022 20:226
  37. Cerebral venous sinus thrombosis (CVST) is a rare neurovascular disorder with highly variable manifestations and clinical courses. Animal models properly matched to the clinical form of CVST are necessary for ...

    Authors: Shuwen Mu, Yinghong Lin, Yongjun Xu, Xianqing Wei, Zihuan Zeng, Kunzhe Lin, Linghua Zhu, Qinghong Liu, Xingfeng Qi, Liangfeng Wei, Shengxiang Liang and Shousen Wang
    Citation: Journal of Translational Medicine 2022 20:174
  38. Stroke, an acute cerebrovascular event, is a leading cause of disability, placing a significant psycho-socioeconomic burden worldwide. The adaptation and reorganization process following any neuronal damage is...

    Authors: Helia Mojtabavi, Zoha Shaka, Sara Momtazmanesh, Atra Ajdari and Nima Rezaei
    Citation: Journal of Translational Medicine 2022 20:126
  39. Pathogenic gain of function variants in Valosin-containing protein (VCP) cause a unique disease characterized by inclusion body myopathy with early-onset Paget disease of bone and frontotemporal dementia (also kn...

    Authors: Cheng Cheng, Lan Weiss, Henri Leinonen, Alyaa Shmara, Hong Z. Yin, Timothy Ton, Annie Do, Jonathan Lee, Lac Ta, Eshanee Mohanty, Jesse Vargas, John Weiss, Krzysztof Palczewski and Virginia Kimonis
    Citation: Journal of Translational Medicine 2022 20:21
  40. Covid-19 became a global pandemic in 2019. Studies have shown that coronavirus can cause neurological symptoms, but clinical studies on its neurological symptoms are limited. In this meta-analysis, we aimed to...

    Authors: Yuanyuan He, Xiaojie Bai, Tiantian Zhu, Jialin Huang and Hong Zhang
    Citation: Journal of Translational Medicine 2021 19:363
  41. Progressive multiple sclerosis (PMS) is an uncommon and severe subtype of MS that worsens gradually and leads to irreversible disabilities in young adults. Currently, there are no applicable or reliable biomar...

    Authors: Fei Ye, Tianzhu Wang, Xiaoxin Wu, Jie Liang, Jiaoxing Li and Wenli Sheng
    Citation: Journal of Translational Medicine 2021 19:316
  42. Inappropriate matching of motor and sensory fibers after nerve repair or nerve grafting can lead to failure of nerve recovery. Identification of motor and sensory fibers is important for the development of new...

    Authors: Xijie Zhou, Jian Du, Liming Qing, Thomas Mee, Xiang Xu, Zhuoran Wang, Cynthia Xu and Xiaofeng Jia
    Citation: Journal of Translational Medicine 2021 19:207
  43. Human oligodendrocyte precursor cells (hOPCs) are an important source of myelinating cells for cell transplantation to treat demyelinating diseases. Myelin oligodendrocytes develop from migratory and prolifera...

    Authors: Haipeng Zhou, Ying He, Zhaoyan Wang, Qian Wang, Caiyan Hu, Xiaohua Wang, Siliang Lu, Ke Li, Yinxiang Yang and Zuo Luan
    Citation: Journal of Translational Medicine 2021 19:188
  44. During intrauterine development, the formation and function of synaptic vesicles (SVs) are thought to be fundamental conditions essential for normal development of the brain. Lacking advanced technology during...

    Authors: Yangwu Fang, Chan Wan, Youlu Wen, Ze Wu, Jing Pan, Mei Zhong and Nanbert Zhong
    Citation: Journal of Translational Medicine 2021 19:154
  45. Pharmacogenomics describes the link between gene variations (polymorphisms) and drug responses. In view of the implementation of precision medicine in personalized healthcare, pharmacogenetic tests have recent...

    Authors: E. Bothos, E. Ntoumou, K. Kelaidoni, D. Roukas, N. Drakoulis, M. Papasavva, F. A. Karakostis, P. Moulos and K. Karakostis
    Citation: Journal of Translational Medicine 2021 19:151
  46. The new wave of anti-migraine agents is nothing less than a milestone in our battle to manage this devastating disease. However, concerns have recently increased regarding the safety of these drugs. CGRP, whil...

    Authors: Mushref Bakri Assas
    Citation: Journal of Translational Medicine 2021 19:23

    The Correction to this article has been published in Journal of Translational Medicine 2021 19:341

  47. Alzheimer’s Disease (AD) is a chronic neurodegenerative disorder characterized by extracellular plaques, intracellular neurofibrillary tangles and neuronal loss in the central nervous system (CNS). Pathogens a...

    Authors: Andrea Saul Costa, Simone Agostini, Franca Rosa Guerini, Roberta Mancuso, Mario Clerici and Janardan P. Pandey
    Citation: Journal of Translational Medicine 2020 18:325

Annual Journal Metrics

  • 2022 Citation Impact
    7.4 - 2-year Impact Factor
    6.9 - 5-year Impact Factor
    1.458 - SNIP (Source Normalized Impact per Paper)
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    5 days submission to first editorial decision for all manuscripts (Median)
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