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Section edited by Maria Jose Polanco Mora

The Neuroscience section aims to encourage publications that help to reduce the gap between basic preclinical science and medical applications for the patients in the neuroscience field.

Featured articles

Betel quid dependence is associated with functional connectivity changes of the anterior cingulate cortex: a resting-state fMRI study
Tao Liu, et al

NGF eye-drops topical administration in patients with retinitis pigmentosa, a pilot study
Benedetto Falsini, et al

Development of patient-derived xenograft models from a spontaneously immortal low-grade meningioma cell line, KCI-MENG1
Sharon K Michelhaugh, et al

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  1. The development of permanent disability in multiple sclerosis (MS) is highly variable among patients, and the exact mechanisms that contribute to this disability remain unknown.

    Authors: Marlene Tahedl, Seth M. Levine, Robert Weissert, Zacharias Kohl, De-Hyung Lee, Ralf A. Linker and Jens V. Schwarzbach
    Citation: Journal of Translational Medicine 2022 20:488
  2. Although anxiety disorders are one of the most prevalent mental disorders, their underlying biological mechanisms have not yet been fully elucidated. In recent years, genetically determined metabolites (GDMs) ...

    Authors: Gui Xiao, Qingnan He, Li Liu, Tingting Zhang, Mengjia Zhou, Xingxing Li, Yijun Chen, Yanyi Chen and Chunxiang Qin
    Citation: Journal of Translational Medicine 2022 20:475
  3. Metabolic disturbance has been reported in patients with epilepsy. Still, the evidence about the causal role of metabolites in facilitating or preventing epilepsy is lacking. Systematically investigating the c...

    Authors: Jiahao Cai, Xiaoyu Li, Shangbin Wu, Yang Tian, Yani Zhang, Zixin Wei, Zixiang Jin, Xiaojing Li, Xiong Chen and Wen-Xiong Chen
    Citation: Journal of Translational Medicine 2022 20:437
  4. Neuroligins are postsynaptic cell adhesion molecules that are relevant to many neurodevelopmental disorders. They are differentially enriched at the postsynapse and interact with their presynaptic ligands, neu...

    Authors: Xing Liu, Fuzhou Hua, Danying Yang, Yue Lin, Lieliang Zhang, Jun Ying, Hongguang Sheng and Xifeng Wang
    Citation: Journal of Translational Medicine 2022 20:418
  5. Glucocorticoid signalling is closely related to both epilepsy and associated cognitive impairment, possibly through mechanisms involving neuronal apoptosis. As a critical enzyme for glucocorticoid action, the ...

    Authors: Xueying Li, Wanhua Qiu, Lu Deng, Jingjing Lin, Wenting Huang, Yuchen Xu, Mulan Zhang, Nigel C. Jones, Runxuan Lin, Huiqin Xu, Li Lin, Peijun Li and Xinshi Wang
    Citation: Journal of Translational Medicine 2022 20:406
  6. With the advent of an aging society, the incidence of dementia is increasing, resulting in a vast burden on society. It is increasingly acknowledged that neuroinflammation is implicated in various neurological...

    Authors: Xiuqin Rao, Fuzhou Hua, Lieliang Zhang, Yue Lin, Pu Fang, Shoulin Chen, Jun Ying and Xifeng Wang
    Citation: Journal of Translational Medicine 2022 20:369
  7. Zishen Pingchan granule (ZPG), a traditional Chinese herbal recipe for treating Parkinson’s disease (PD), is usually used as an add-on drug with some antiparkinsonian drugs in China. The objectives of this stu...

    Authors: Houxu Ning, Hao Zhou, Jingru Ren, Gaiyan Zhou, Ning Yang, Zhenfu Wang, Canxing Yuan, Zuojun Tian, Juping Chen, Lihua Shen, Huifen Zheng, Yang Zhao, Haidong Wang, Weiguo Liu and Zhenguo Liu
    Citation: Journal of Translational Medicine 2022 20:357
  8. In polyglutamine (polyQ) diseases, the identification of modifiers and the construction of prediction model for progression facilitate genetic counseling, clinical management and therapeutic interventions.

    Authors: Linliu Peng, Yun Peng, Zhao Chen, Chunrong Wang, Zhe Long, Huirong Peng, Yuting Shi, Lu Shen, Kun Xia, Vanessa B. Leotti, Laura Bannach Jardim, Beisha Tang, Rong Qiu and Hong Jiang
    Citation: Journal of Translational Medicine 2022 20:226
  9. Cerebral venous sinus thrombosis (CVST) is a rare neurovascular disorder with highly variable manifestations and clinical courses. Animal models properly matched to the clinical form of CVST are necessary for ...

    Authors: Shuwen Mu, Yinghong Lin, Yongjun Xu, Xianqing Wei, Zihuan Zeng, Kunzhe Lin, Linghua Zhu, Qinghong Liu, Xingfeng Qi, Liangfeng Wei, Shengxiang Liang and Shousen Wang
    Citation: Journal of Translational Medicine 2022 20:174
  10. Stroke, an acute cerebrovascular event, is a leading cause of disability, placing a significant psycho-socioeconomic burden worldwide. The adaptation and reorganization process following any neuronal damage is...

    Authors: Helia Mojtabavi, Zoha Shaka, Sara Momtazmanesh, Atra Ajdari and Nima Rezaei
    Citation: Journal of Translational Medicine 2022 20:126
  11. Pathogenic gain of function variants in Valosin-containing protein (VCP) cause a unique disease characterized by inclusion body myopathy with early-onset Paget disease of bone and frontotemporal dementia (also kn...

    Authors: Cheng Cheng, Lan Weiss, Henri Leinonen, Alyaa Shmara, Hong Z. Yin, Timothy Ton, Annie Do, Jonathan Lee, Lac Ta, Eshanee Mohanty, Jesse Vargas, John Weiss, Krzysztof Palczewski and Virginia Kimonis
    Citation: Journal of Translational Medicine 2022 20:21
  12. Covid-19 became a global pandemic in 2019. Studies have shown that coronavirus can cause neurological symptoms, but clinical studies on its neurological symptoms are limited. In this meta-analysis, we aimed to...

    Authors: Yuanyuan He, Xiaojie Bai, Tiantian Zhu, Jialin Huang and Hong Zhang
    Citation: Journal of Translational Medicine 2021 19:363
  13. Progressive multiple sclerosis (PMS) is an uncommon and severe subtype of MS that worsens gradually and leads to irreversible disabilities in young adults. Currently, there are no applicable or reliable biomar...

    Authors: Fei Ye, Tianzhu Wang, Xiaoxin Wu, Jie Liang, Jiaoxing Li and Wenli Sheng
    Citation: Journal of Translational Medicine 2021 19:316
  14. Inappropriate matching of motor and sensory fibers after nerve repair or nerve grafting can lead to failure of nerve recovery. Identification of motor and sensory fibers is important for the development of new...

    Authors: Xijie Zhou, Jian Du, Liming Qing, Thomas Mee, Xiang Xu, Zhuoran Wang, Cynthia Xu and Xiaofeng Jia
    Citation: Journal of Translational Medicine 2021 19:207
  15. Human oligodendrocyte precursor cells (hOPCs) are an important source of myelinating cells for cell transplantation to treat demyelinating diseases. Myelin oligodendrocytes develop from migratory and prolifera...

    Authors: Haipeng Zhou, Ying He, Zhaoyan Wang, Qian Wang, Caiyan Hu, Xiaohua Wang, Siliang Lu, Ke Li, Yinxiang Yang and Zuo Luan
    Citation: Journal of Translational Medicine 2021 19:188
  16. During intrauterine development, the formation and function of synaptic vesicles (SVs) are thought to be fundamental conditions essential for normal development of the brain. Lacking advanced technology during...

    Authors: Yangwu Fang, Chan Wan, Youlu Wen, Ze Wu, Jing Pan, Mei Zhong and Nanbert Zhong
    Citation: Journal of Translational Medicine 2021 19:154
  17. Pharmacogenomics describes the link between gene variations (polymorphisms) and drug responses. In view of the implementation of precision medicine in personalized healthcare, pharmacogenetic tests have recent...

    Authors: E. Bothos, E. Ntoumou, K. Kelaidoni, D. Roukas, N. Drakoulis, M. Papasavva, F. A. Karakostis, P. Moulos and K. Karakostis
    Citation: Journal of Translational Medicine 2021 19:151
  18. The new wave of anti-migraine agents is nothing less than a milestone in our battle to manage this devastating disease. However, concerns have recently increased regarding the safety of these drugs. CGRP, whil...

    Authors: Mushref Bakri Assas
    Citation: Journal of Translational Medicine 2021 19:23

    The Correction to this article has been published in Journal of Translational Medicine 2021 19:341

  19. Alzheimer’s Disease (AD) is a chronic neurodegenerative disorder characterized by extracellular plaques, intracellular neurofibrillary tangles and neuronal loss in the central nervous system (CNS). Pathogens a...

    Authors: Andrea Saul Costa, Simone Agostini, Franca Rosa Guerini, Roberta Mancuso, Mario Clerici and Janardan P. Pandey
    Citation: Journal of Translational Medicine 2020 18:325
  20. The intrathecal (IT) dosing route introduces drugs directly into the CSF to bypass the blood–brain barrier and gain direct access to the CNS. We evaluated the use of convective forces acting on the cerebrospin...

    Authors: Jenna M. Sullivan, Curt Mazur, Daniel A. Wolf, Laura Horky, Nicolas Currier, Bethany Fitzsimmons, Jacob Hesterman, Rachel Pauplis, Scott Haller, Berit Powers, Leighla Tayefeh, Bea DeBrosse-Serra, Jack Hoppin, Holly Kordasiewicz, Eric E. Swayze and Ajay Verma
    Citation: Journal of Translational Medicine 2020 18:309
  21. Ischemic stroke (IS) is the second leading cause of death worldwide which is a serious hazard to human health. Evidence suggests that the immune system plays a key role in the pathophysiology of IS. However, t...

    Authors: Zijian Li, Yueran Cui, Juan Feng and Yanxia Guo
    Citation: Journal of Translational Medicine 2020 18:296
  22. Brain aging is a major risk factor in the progression of cognitive diseases including Alzheimer’s disease (AD) and vascular dementia. We investigated a mouse model of brain aging up to 24 months old (mo).

    Authors: Erik N. Taylor, Nasi Huang, Jonathan Wisco, Yandan Wang, Kathleen G. Morgan and James A. Hamilton
    Citation: Journal of Translational Medicine 2020 18:277
  23. 17AAG has been extensively studied for its antitumor effects that protect cells from lethal stress by maintaining protein stability. The role of 17AAG in sevoflurane-induced neuronal injury has never been stud...

    Authors: Min Liu, Moyun Li, Yu Zhou, Qian Zhou and Yugang Jiang
    Citation: Journal of Translational Medicine 2020 18:166
  24. Machado–Joseph disease (MJD), also known as spinocerebellar ataxia type 3, is the most common of the dominantly inherited ataxias worldwide and is characterized by mutant ataxin-3 aggregation and neuronal dege...

    Authors: Magda M. Santana, Susana Paixão, Janete Cunha-Santos, Teresa Pereira Silva, Allyson Trevino-Garcia, Laetitia S. Gaspar, Clévio Nóbrega, Rui Jorge Nobre, Cláudia Cavadas, Hagar Greif and Luís Pereira de Almeida
    Citation: Journal of Translational Medicine 2020 18:161
  25. Peroxiredoxin activated in M-CSF stimulated monocytes (PAMM) is a novel protein produced by adipocytes with putative redox regulatory and anti-inflammatory properties. Because acute spinal cord injury (SCI) is...

    Authors: Leslie R. Morse, Nguyen Nguyen, Yan Xu, Prakash Jha and Ricardo A. Battaglino
    Citation: Journal of Translational Medicine 2020 18:135
  26. Inflammatory damage following stroke aggravates brain damage, resulting in long-term neurological sequelae. The purpose of this study was to identify ways to reduce inflammatory reactions and to accelerate neu...

    Authors: Benping Zhang, Qian Li, Shuwei Jia, Feng Li, Qingsong Li and Jiebing Li
    Citation: Journal of Translational Medicine 2020 18:110
  27. Myelin sheaths surrounding axons are critical for electrical signal transmission in the central nervous system (CNS). Diseases with myelin defects such as multiple sclerosis (MS) are devastating neurological c...

    Authors: Sujun Ding, Yun Gu, Yunyun Cai, Meijuan Cai, Tuo Yang, Shuangxi Bao, Weixing Shen, Xuejun Ni, Gang Chen and Lingyan Xing
    Citation: Journal of Translational Medicine 2020 18:109
  28. Parkinson’s disease (PD) is a neurodegenerative disorder that results in the death of dopaminergic neurons within the substantia nigra pars compacta and the reduction in dopaminergic control over striatal output ...

    Authors: Inma Castilla-Cortázar, Gabriel A. Aguirre, Giovana Femat-Roldán, Irene Martín-Estal and Luis Espinosa
    Citation: Journal of Translational Medicine 2020 18:70
  29. Gap junctions are involved in the development of cerebral vasospasm (CVS) after subarachnoid hemorrhage (SAH). However, the specific roles and regulatory functions of related connexin isoforms remain unknown. ...

    Authors: Le Yang, Jian Yan, Jin-An Zhang, Xin-Hui Zhou, Chao Fang, Er-Ming Zeng, Bin Tang, Jian Duan, Guo-Hui Lu and Tao Hong
    Citation: Journal of Translational Medicine 2019 17:433
  30. Xenon (Xe) is a noble gas that has been used for the last several decades as an anesthetic during surgery. Its antagonistic effect on glutamate subtype of NMDA (N-methyl-d-aspartate) receptors resulted in evaluat...

    Authors: A. P. Dobrovolsky, V. R. Gedzun, V. I. Bogin, D. Ma, T. E. Ichim, Iu. A. Sukhanova, A. V. Malyshev and V. A. Dubynin
    Citation: Journal of Translational Medicine 2019 17:400
  31. Developmental processes in the placenta and the fetal brain are shaped by the similar biological signals. Evidence accumulates that adaptive responses of the placenta may influence central nervous system devel...

    Authors: Esmée M. Bijnens, Catherine Derom, Steven Weyers, Bram G. Janssen, Evert Thiery and Tim S. Nawrot
    Citation: Journal of Translational Medicine 2019 17:361
  32. Biallelic PTPRQ pathogenic variants have been previously reported as causative for autosomal recessive non-syndromic hearing loss. In 2018 the first heterozygous PTPRQ variant has been implicated in the developme...

    Authors: Dominika Oziębło, Anna Sarosiak, Marcin L. Leja, Birgit S. Budde, Grażyna Tacikowska, Nataliya Di Donato, Hanno J. Bolz, Peter Nürnberg, Henryk Skarżyński and Monika Ołdak
    Citation: Journal of Translational Medicine 2019 17:351
  33. It has been established that children with Autism Spectrum Disorders (ASD) are affected by oxidative stress, the origin of which is still under investigation. In the present work, we evaluated inflammatory and...

    Authors: P. M. Abruzzo, A. Matté, A. Bolotta, E. Federti, A. Ghezzo, T. Guarnieri, M. Marini, A. Posar, A. Siciliano, L. De Franceschi and P. Visconti
    Citation: Journal of Translational Medicine 2019 17:332
  34. Hearing loss (HL) is the most common disability of human senses characterized by a great allelic heterogeneity. GJB2 and TMPRSS3 are two well-known HL genes typically underlying its monogenic form. Recently, TMPR...

    Authors: Monika Ołdak, Urszula Lechowicz, Agnieszka Pollak, Dominika Oziębło and Henryk Skarżyński
    Citation: Journal of Translational Medicine 2019 17:269
  35. The adipose afferent reflex (AAR), a sympatho-excitatory reflex, can promote the elevation of sympathetic nerve activity (SNA) and blood pressure (BP). Inflammation in the paraventricular nucleus (PVN) involve...

    Authors: Lei Ding, Ying Kang, Hang-Bing Dai, Fang-Zheng Wang, Hong Zhou, Qing Gao, Xiao-Qing Xiong, Feng Zhang, Tian-Run Song, Yan Yuan, Ming Liu, Guo-Qing Zhu and Ye-Bo Zhou
    Citation: Journal of Translational Medicine 2019 17:256
  36. Acute ischemic stroke (AIS) due to large vessel occlusion (LVO) is a devastating cerebrovascular disorder, which could benefit from collateral circulation. Proteins associated with acute LVO pathogenesis and e...

    Authors: Chuan Qin, Xin-Ling Zhao, Xiao-Tong Ma, Luo-Qi Zhou, Long-jun Wu, Ke Shang, Wei Wang and Dai-Shi Tian
    Citation: Journal of Translational Medicine 2019 17:214
  37. Flow diverter devices are increasingly used for endovascular treatment of internal carotid artery aneurysms. Treatment of ophthalmic segment aneurysms with flow diverter devices also includes coverage of the o...

    Authors: Xinzhi Wu, Zhongbin Tian, Jian Liu, Wenqiang Li, Junfan Chen, Yangyang Zhou, Xinjian Yang and Shiqing Mu
    Citation: Journal of Translational Medicine 2019 17:160
  38. Changes in brain metabolism has been investigated thoroughly during unilateral cervical chronic vagal stimulation in epileptic or depressive patients. Bilateral stimulation of the abdominal vagus (aVNS) has recei...

    Authors: Charles-Henri Malbert, Mickael Genissel, Jean-Louis Divoux and Christine Henry
    Citation: Journal of Translational Medicine 2019 17:78
  39. There are no guidelines concerning the best approach to improving sleep, but it has been shown that it can benefit the affected children and their entire families. The aim of this review is to analyse the effi...

    Authors: Susanna Esposito, Daniela Laino, Renato D’Alonzo, Annalisa Mencarelli, Lorenza Di Genova, Antonella Fattorusso, Alberto Argentiero and Elisabetta Mencaroni
    Citation: Journal of Translational Medicine 2019 17:77
  40. Glioblastoma multiform (GBM) is a devastating brain tumor with maximum surgical resection, radiotherapy plus concomitant and adjuvant temozolomide (TMZ) as the standard treatment. Diverse clinicopathological a...

    Authors: Wei-Zhen Gao, Lie-Mei Guo, Tian-Qi Xu, Yu-Hua Yin and Feng Jia
    Citation: Journal of Translational Medicine 2018 16:368
  41. Neurogenic bowel dysfunction (NBD) is a major physical and psychological problem in patients with spinal cord injury (SCI), and gut dysbiosis is commonly occurs in SCI. Here, we document neurogenic bowel manag...

    Authors: Chao Zhang, Wenhao Zhang, Jie Zhang, Yingli Jing, Mingliang Yang, Liangjie Du, Feng Gao, Huiming Gong, Liang Chen, Jun Li, Hongwei Liu, Chuan Qin, Yanmei Jia, Jiali Qiao, Bo Wei, Yan Yu…
    Citation: Journal of Translational Medicine 2018 16:353
  42. Acute ischemic stroke is a leading cause of mortality and long-term disability, and profiles of endothelial progenitor cells (EPCs) reflect the degree of endothelial impairment. This study tested the hypothesi...

    Authors: Chen-Yu Chen, Re-Wen Wu, Nai-Wen Tsai, Mel S. Lee, Wei-Che Lin, Mei-Chi Hsu, Chih-Cheng Huang, Yun-Ru Lai, Chia-Te Kung, Hung-Chen Wang, Yu-Jih Su, Chih-Min Su, Sheng-Yuan Hsiao, Ben-Chung Cheng, Yi-Fang Chiang and Cheng-Hsien Lu
    Citation: Journal of Translational Medicine 2018 16:255
  43. Fatigue is a common problem among individuals with Parkinson’s disease (PD). It may occur before the overt symptoms of bradykinesia, rigidity and tremor. Little is understood about how to measure fatigue in PD...

    Authors: Raymond Chong, Lauren Albor, Chandramohan Wakade and John Morgan
    Citation: Journal of Translational Medicine 2018 16:192
  44. For nearly four decades, the N400 has been an important brainwave marker of semantic processing. It can be recorded non-invasively from the scalp using electrical and/or magnetic sensors, but largely within th...

    Authors: Sujoy Ghosh Hajra, Careesa C. Liu, Xiaowei Song, Shaun D. Fickling, Teresa P. L. Cheung and Ryan C. N. D’Arcy
    Citation: Journal of Translational Medicine 2018 16:151
  45. Mental illness contributes substantially to global disease burden, particularly when illness onset occurs during youth and help-seeking is delayed and/or limited. Yet, few mental health promotion interventions...

    Authors: Joanna Yang, Roberto Lopez Cervera, Susannah J. Tye, Stephen C. Ekker and Chris Pierret
    Citation: Journal of Translational Medicine 2018 16:84
  46. Magnetic stimulation of the facial nerve has been tested in preclinical studies as a new, non-invasive emergency treatment of ischemic stroke that acts by increasing cerebral blood flow (CBF). The objective of...

    Authors: Olivia Sanchez, Andrea García, Fernando Castro-Prado, Miriam Perez, Rafael Lara-Estrada, Martin Ramirez-Meza, Montserrat Godinez, Michael L. Coco, Joaquín Azpiroz, Mark K. Borsody and Emilio Sacristán
    Citation: Journal of Translational Medicine 2018 16:27

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