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  1. Increasing evidence supports the concept of prenatal programming as an early factor in the aging process. DNA methylation age (DNAm age), global genome-wide DNA methylation (global methylation), telomere lengt...

    Authors: Brigitte Reimann, Dries S. Martens, Congrong Wang, Akram Ghantous, Zdenko Herceg, Michelle Plusquin and Tim S. Nawrot
    Citation: Journal of Translational Medicine 2022 20:353
  2. The purpose of this study was to observe the harm of circadian misalignment (CM), caused by an inverted photoperiod (IP), on the hearts of the adolescent Wistar rats, and to explore the mechanisms leading to h...

    Authors: YunLei Wang, YuanYuan Hou, ShaoFei Song, Yao Zuo, Yan Yu, YaFei Chi and Tong Zhang
    Citation: Journal of Translational Medicine 2022 20:352
  3. The resistance to radiotherapy remains a major obstacle that limits the efficacy of radiotherapy in non-small cell lung cancer (NSCLC). This study aims to illustrate the molecular mechanism underlying the role...

    Authors: Li-Ming Xu, Ya-Jing Yuan, Hao Yu, Shuai Wang and Ping Wang
    Citation: Journal of Translational Medicine 2022 20:350
  4. Lung cancer is the second cancer and the leading cause of tumor-related mortality worldwide. Angiogenesis is a crucial hallmark of cancer development and a promising target in lung cancer. However, the anti-an...

    Authors: Yajie Liao, Xudong Wu, Mengyu Wu, Yuan Fang, Jie Li and Weiqiang Tang
    Citation: Journal of Translational Medicine 2022 20:349
  5. Doxorubicin (Dox) is the standard treatment approach for osteosarcoma (OS), while acquired drug resistance seriously attenuates its treatment efficiency. The present study aimed to investigate the potential ro...

    Authors: Qing He, Peng Hao, Gang He, Hantao Mai, Wenzhou Liu, Weiqiong Zhang, Kelin Zhang, Guifang Zhong, Ruilian Guo, Changzhi Yu, Yang Li, Chipiu Wong, Qian Chen and Yantao Chen
    Citation: Journal of Translational Medicine 2022 20:348
  6. Castration-resistant prostate cancer (CRPC) is a major cause of recurrence and mortality among prostate cancer (PCa) patients. Myeloid-derived suppressor cells (MDSCs) regulate castration resistance in PCa. Pr...

    Authors: Feng Gao, Qiaoping Xu, Zhe Tang, Nan Zhang, Yasheng Huang, Zhongyi Li, Yuliang Dai, Qiqi Yu and Jingyu Zhu
    Citation: Journal of Translational Medicine 2022 20:346
  7. We and others have previously demonstrated that the size-selection enrichment method could remarkably improve fetal fraction (FF) in the early gestational age (GA, 12–13 weeks), suggesting that 9 or 10 weeks s...

    Authors: Longwei Qiao, Bin Zhang, Xiaojuan Wu, Chunhua Zhang, Ying Xue, Hui Tang, Haoyu Tang, Jingye Shi, Yuting Liang, Bin Yu and Ting Wang
    Citation: Journal of Translational Medicine 2022 20:345
  8. Several studies suggest that dietary fiber intake may reduce mortality risk, but this might depend on the fiber types and the evidence regarding the role of soluble fiber or insoluble fiber on death risk remai...

    Authors: Xin Xu, Junmiao Zhang, Yanhui Zhang, Honggang Qi and Ping Wang
    Citation: Journal of Translational Medicine 2022 20:344
  9. PolyC-RNA-binding protein 1 (PCBP1) functions as a tumour suppressor and RNA regulator that is downregulated in human cancers. Here, we aimed to reveal the biological function of PCBP1 in lung adenocarcinoma (...

    Authors: Yujia Zheng, Zheng Zhou, Ran Wei, Chu Xiao, Hao Zhang, Tao Fan, Bo Zheng, Chunxiang Li and Jie He
    Citation: Journal of Translational Medicine 2022 20:343
  10. NAFLD and NASH are emerging as primary causes of chronic liver disease, indicating a need for an effective treatment. Mutaflor® probiotic, a microbial treatment of interest, was effective in sustaining remissi...

    Authors: Noha M. Hany, Sanaa Eissa, Manal Basyouni, Amany H. Hasanin, Yasmin M. Aboul-Ela, Nagwa M. Abo Elmagd, Iman F. Montasser, Mahmoud A. Ali, Paul J. Skipp and Marwa Matboli
    Citation: Journal of Translational Medicine 2022 20:342
  11. Vascular endothelial growth factor B (VEGFB) was regarded to improve lipid metabolism and reduce obesity-related hyperlipidemia. Whether VEGFB participates in lipid metabolism in nonalcoholic fatty liver disea...

    Authors: Rongrong Li, Yuqi Li, Xueling Yang, Yaorui Hu, Haining Yu and Yana Li
    Citation: Journal of Translational Medicine 2022 20:341
  12. Physical independence is crucial for overall health in the elderly individuals. The life expectancy of women has been shown to be higher than that of men, which is also known as the “male–female health-surviva...

    Authors: Qiao Zhu, Ping Ping, Pei Zhang, Chaoxue Ning, Yali Zhao, Yao Yao, Xiubing Li and Shihui Fu
    Citation: Journal of Translational Medicine 2022 20:340
  13. The overall survival (OS) of stage I operable lung cancer is relatively low, and not all patients can benefit from adjuvant chemotherapy. This study aimed to develop and validate a radiomic signature (RS) for ...

    Authors: Wei Nie, Guangyu Tao, Zhenghai Lu, Jie Qian, Yaqiong Ge, Shuyuan Wang, Xueyan Zhang, Hua Zhong and Hong Yu
    Citation: Journal of Translational Medicine 2022 20:339
  14. Cytokine release syndrome (CRS) is a strong immune system response that can occur as a result of the reaction of a cellular immunotherapy with malignant cells. While the frequency and management of CRS in CAR ...

    Authors: Lipei Shao, Alejandra Pelayo, Rongye Shi, Jinxia Ma, Hui Liu, Yihua Cai, Michaela Prochazkova, Robert P. Somerville, Sandhya R. Panch, Nirali N. Shah, David F. Stroncek and Ping Jin
    Citation: Journal of Translational Medicine 2022 20:338
  15. Asprosin, a newly discovered adipokine, is a C-terminal cleavage product of profibrillin. Asprosin has been reported to participate in lipid metabolism and cardiovascular disease, but its role in atherogenesis...

    Authors: Jin Zou, Can Xu, Zhen-Wang Zhao, Shan-Hui Yin and Gang Wang
    Citation: Journal of Translational Medicine 2022 20:337
  16. Endometrial cancer (EC) is the most common gynecological malignancy in developed countries. Efficacy of the bromodomain 4 (BRD4) inhibitor JQ1 has been reported for the treatment of various human cancers, but ...

    Authors: Yingxin Pang, Gaigai Bai, Jing Zhao, Xuan Wei, Rui Li, Jie Li, Shunxue Hu, Lu Peng, Peishu Liu and Hongluan Mao
    Citation: Journal of Translational Medicine 2022 20:336
  17. Glioma is the most common cancer in the central nervous system, and low grade gliomas are notorious for many types of tumors and heterogeneity. PROS1 not only plays an important role in the blood coagulation syst...

    Authors: Yujie Zhou, Dongdong Xiao and Xiaobing Jiang
    Citation: Journal of Translational Medicine 2022 20:335
  18. Effective treatment is needed for advanced, inoperable, or chemotherapy-resistant cervical cancer patients. Immunotherapy has become a new treatment modality for cervical cancer patients, and there is an urgen...

    Authors: Siyang Zhang, Han Wang, Jiao Liu, Tao Tao, Zhi Zeng and Min Wang
    Citation: Journal of Translational Medicine 2022 20:334
  19. Hyperkalemia is a common and potentially life-threatening electrolyte disorder in maintenance hemodialysis (MHD) patients. This study aimed to evaluate the efficacy and safety of potassium-lowering regimens du...

    Authors: Lan Yao, Xiaoyang Xing, Yubao Li, Fangxing Zhang, Ping Li, Xianhui Liang and Pei Wang
    Citation: Journal of Translational Medicine 2022 20:333
  20. Except for B7-CD28 family members, more novel immune checkpoints are being discovered. They are closely associated with tumor immune microenvironment and regulate the function of many immune cells. Various can...

    Authors: Nan Sun, Yuejun Luo, Bo Zheng, Zhihui Zhang, Chaoqi Zhang, Zhen Zhang, Guochao Zhang, Fengwei Tan, Qi Xue, Shugeng Gao and Jie He
    Citation: Journal of Translational Medicine 2022 20:332
  21. The effectiveness of MAPK pathway inhibitors (MAPKi) used to treat patients with BRAF-mutant melanoma is limited by a range of resistance mechanisms, including soluble TNF (solTNF)-mediated NF-kB signaling. so...

    Authors: Cindy A. Sander, Elizabeth A. Rush, Jian Shi, Lidia M. R. B. Arantes, Raymond J. Tesi, Mark A. Ross, Michael J. Calderon, Simon C. Watkins, John M. Kirkwood, Robert L. Ferris, Lisa H. Butterfield and Lazar Vujanovic
    Citation: Journal of Translational Medicine 2022 20:331
  22. Glutamine is the most abundant amino acid in the body and plays a vital role in colorectal cancer (CRC) cell metabolism. However, limited studies have investigated the clinical and prognostic significance of p...

    Authors: Hongyan Sun, Chuan Zhang, Yang Zheng, Chenlu Liu, Xue Wang and Xianling Cong
    Citation: Journal of Translational Medicine 2022 20:330
  23. A piglet model for peritoneal metastasis (PM) of ovarian cancer was developed. It will contribute to establishing innovative chemotherapeutical and surgical strategies without any limitation on rodent models.

    Authors: Eun Ji Lee, Soo Jin Park, Aeran Seol, Hyunji Lim, Sumin Park, Ji Yeon Ahn, Jeong Mook Lim and Hee Seung Kim
    Citation: Journal of Translational Medicine 2022 20:329
  24. Necroptosis plays a major role in breast cancer (BC) progression and metastasis. Besides, necroptosis also regulates inflammatory response and tumor microenvironment. Here, we aim to explore the predictive sig...

    Authors: Honghao Yu, Wenchang Lv, Yufang Tan, Xiao He, Yiping Wu, Min Wu and Qi Zhang
    Citation: Journal of Translational Medicine 2022 20:328
  25. Recent studies have shown that the fox family plays a vital role in tumorigenesis and progression. Forkhead Box S1 (FOXS1), as a newly identified subfamily of the FOX family, is overexpressed in certain types ...

    Authors: Liang Zhang, Chuan-fu Ren, Zhi Yang, Long-bo Gong, Chao Wang, Min Feng and Wen-xian Guan
    Citation: Journal of Translational Medicine 2022 20:327
  26. Our previous study has identified a novel circRNA (circDIDO1) that is down-regulated in gastric cancer (GC) and significantly inhibits GC progression. The purpose of this study is to identify the molecular mec...

    Authors: Zhen Guo, Yu Zhang, Wenrong Xu, Xu Zhang and Jiajia Jiang
    Citation: Journal of Translational Medicine 2022 20:326
  27. NCAPG, non-SMC subunit in the concentrate I complex, might promote the proliferation of hepatocellular carcinoma (HCC), but the mechanism is unclear. The aim of this study was to explore how NCAPG affects PTEN...

    Authors: Rongguiyi Zhang, Jiyuan Ai, Jiakun Wang, Chi sun, Hongcheng Lu, Aoxiao He, Min Li, Yuting Liao, Jun Lei, Fan Zhou, Linquan Wu and Wenjun Liao
    Citation: Journal of Translational Medicine 2022 20:325
  28. Kidney transplantation is a lifesaving option for patients with end-stage kidney disease. In Taiwan, urothelial carcinoma (UC) is the most common de novo cancer after kidney transplantation (KT). UC has a grea...

    Authors: Lee-Moay Lim, Wen-Yu Chung, Daw-Yang Hwang, Chih-Chuan Yu, Hung-Lung Ke, Peir-In Liang, Ting-Wei Lin, Siao Muk Cheng, A-Mei Huang and Hung-Tien Kuo
    Citation: Journal of Translational Medicine 2022 20:324
  29. Despite promising results in clinical studies, the mechanism for the beneficial effects of allogenic cell-based therapies remains unclear. Macrophages are not only critical mediators of inflammation but also c...

    Authors: Rachana Mishra, Progyaparamita Saha, Srinivasa Raju Datla, Pranav Mellacheruvu, Muthukumar Gunasekaran, Sameer Ahmad Guru, Xubin Fu, Ling Chen, Roberto Bolli, Sudhish Sharma and Sunjay Kaushal
    Citation: Journal of Translational Medicine 2022 20:323
  30. Helicobacter pylori (H. pylori) can disrupt the tight junctions between gastric epithelial cells and penetrate the intercellular spaces acting on epithelial cells, normal fibroblasts (NFs), and cancer-associated ...

    Authors: Xueshu Chen, Wei Chen, Yan Zhao, Qinrong Wang, Wenling Wang, Yining Xiang, Hang Yuan, Yuan Xie and Jianjiang Zhou
    Citation: Journal of Translational Medicine 2022 20:322
  31. The immune system plays a vital role in the pathophysiology of acute myocardial infarction (AMI). However, the exact immune related mechanism is still unclear. This research study aimed to identify key immune-...

    Authors: Peng-Fei Zheng, Qiong-Chao Zou, Lu-Zhu Chen, Peng Liu, Zheng-Yu Liu and Hong-Wei Pan
    Citation: Journal of Translational Medicine 2022 20:321
  32. As an important component of the immunosuppressive tumor microenvironment (TME), it has been established that mesenchymal stem cells (MSCs) promote the progression of tumor cells. MSCs can directly promote the...

    Authors: Zhenghou Zhang, Xiangyu Zhou, Jinshuai Guo, Fusheng Zhang, Yiping Qian, Guang Wang, Meiqi Duan, Yutian Wang, Haiying Zhao, Zhi Yang, Zunpeng Liu and Xiaofeng Jiang
    Citation: Journal of Translational Medicine 2022 20:320
  33. Cardiovascular diseases (CVDs) are a significant cause of mortality worldwide and are characterized by severe atherosclerosis (AS) in patients. However, the molecular mechanism of AS formation remains elusive....

    Authors: Jiaxin Hu, Ying Zhang, Liaoping Hu, Haiting Chen, Han Wu, Jianzhou Chen, Jun Xie, Biao Xu and Zhonghai Wei
    Citation: Journal of Translational Medicine 2022 20:319
  34. Circular RNAs (circRNAs) belong to a novel class of noncoding RNA that gained more attention in human cancer pathogenesis. The role of circRNA in esophageal squamous cell carcinoma (ESCC) is largely unclear. P...

    Authors: Pei Xu, Lei Wang, Qingtao Liu, Pengkai Gao, Fengqing Hu, Xiao Xie, Lianyong Jiang, Rui Bi, Fangbao Ding, Qi Yang and Haibo Xiao
    Citation: Journal of Translational Medicine 2022 20:318
  35. Authors: Åslaug Helland, Hege G. Russnes, Gro Live Fagereng, Khalid Al-Shibli, Yvonne Andersson, Thomas Berg, Line Bjørge, Egil Blix, Bodil Bjerkehagen, Sigmund Brabrand, Marte Grønlie Cameron, Astrid Dalhaug, Dalia Dietzel, Tom Dønnem, Espen Enerly, Åsmund Flobak…
    Citation: Journal of Translational Medicine 2022 20:317

    The original article was published in Journal of Translational Medicine 2022 20:225

  36. The gut microbiota profile is unique for each individual and are composed by different bacteria species according to individual birth-to-infant transitions. In the last years, the local and systemic effects of...

    Authors: Concetta Ragone, Carmen Manolio, Angela Mauriello, Beatrice Cavalluzzo, Franco M. Buonaguro, Maria Lina Tornesello, Maria Tagliamonte and Luigi Buonaguro
    Citation: Journal of Translational Medicine 2022 20:316
  37. Enolase is an essential enzyme in the process of glycolysis and has been implicated in cancer progression. Though dysregulation of ENOs has been reported in multiple cancers, their prognostic value and specifi...

    Authors: Zhengnan Huang, Yilin Yan, Tengjiao Wang, Zeyi Wang, Jinming Cai, Xiangqian Cao, Chenkai Yang, Fang Zhang, Gang Wu and Bing Shen
    Citation: Journal of Translational Medicine 2022 20:315
  38. The outbreak of SARS-CoV-2 continues to pose a serious threat to human health and social. The ongoing pandemic of COVID-19 caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has made a ...

    Authors: Changzhi Li, Hongjuan Zhou, Lingling Guo, Dehuan Xie, Huiping He, Hong Zhang, Yixiu Liu, Lixia Peng, Lisheng Zheng, Wenhua Lu, Yan Mei, Zhijie Liu, Jie Huang, Mingdian Wang, Ditian Shu, Liuyan Ding…
    Citation: Journal of Translational Medicine 2022 20:314
  39. Homologous recombination deficiency (HRD) is closely associated with patient prognosis and treatment options in prostate cancer (PCa). However, there is a lack of quantitative indicators related to HRD to pred...

    Authors: Cong Luo, Zhi Liu, Yu Gan, Xiaomei Gao, Xiongbing Zu, Ye Zhang, Wenrui Ye and Yi Cai
    Citation: Journal of Translational Medicine 2022 20:313
  40. The oral ecosystem conditions dental health, and is known to be positively modified by oral hygiene which cannot always be performed between meals, especially outside home. It is therefore important to identif...

    Authors: Erna Cecilia Lorenzini, Barbara Lazzari, Gianluca Martino Tartaglia, Giampietro Farronato, Valentina Lanteri, Sara Botti, Filippo Biscarini, Paolo Cozzi and Alessandra Stella
    Citation: Journal of Translational Medicine 2022 20:312
  41. Acute Myeloid Leukaemia (AML) is a haematological malignancy showing a hypervariable landscape of clinical outcomes and phenotypic differences, explainable by heterogeneity at the cellular and molecular level....

    Authors: Gabriele Lo Iudice, Eleonora De Bellis, Arianna Savi, Luca Guarnera, Alice Massacci, Francesca De Nicola, Frauke Goeman, Tiziana Ottone, Mariadomenica Divona, Matteo Pallocca, Maurizio Fanciulli, Maria Teresa Voso and Gennaro Ciliberto
    Citation: Journal of Translational Medicine 2022 20:311
  42. Increasing evidence indicates that myocardial oxidative injury plays a crucial role in the pathophysiology of cardiac hypertrophy (CH) and heart failure (HF). The active component of rhubarb, rhein exerts sign...

    Authors: Wei Lu, Hongqiao Zhu, Jiawen Wu, Sheng Liao, Guobing Cheng and Xiaoyang Li
    Citation: Journal of Translational Medicine 2022 20:305
  43. Although eukaryotic initiation factor 6 (eIF6) is a novel therapeutic target, data on its importance in the development of esophageal carcinoma (ESCA) remains limited. This study evaluated the correlation betw...

    Authors: Yan Gao, Lingling Yuan, Jing Zeng, Fuyan Li, Xiaohui Li, Fan Tan, Xusheng Liu, Huabing Wan, Xueyan Kui, Xiaoyu Liu, Changbin Ke and Zhijun Pei
    Citation: Journal of Translational Medicine 2022 20:303
  44. The tumor-promoting role of tumor microenvironment (TME) in colorectal cancer has been widely investigated in cancer biology. Cancer-associated fibroblasts (CAFs), as the main stromal component in TME, play an...

    Authors: Zhiwei Peng, Manping Ye, Huiming Ding, Zhenyou Feng and Kongwang Hu
    Citation: Journal of Translational Medicine 2022 20:302
  45. In recent years, there has been a greater emphasis on the impact of microbial populations inhabiting the gastrointestinal tract on human health and disease. According to the involvement of microbiota in modula...

    Authors: Hourieh Sadrekarimi, Zhanna R. Gardanova, Morteza Bakhshesh, Farnoosh Ebrahimzadeh, Amirhossein Fakhre Yaseri, Lakshmi Thangavelu, Zahra Hasanpoor, Firoozeh Abolhasani Zadeh and Mohammad Saeed Kahrizi
    Citation: Journal of Translational Medicine 2022 20:301
  46. Despite advances in targeted agent development, effective treatment of acute myeloid leukemia (AML) remains a major clinical challenge. The B-cell lymphoma-2 (BCL-2) inhibitor exhibited promising clinical acti...

    Authors: Wenwen Wei, Shujuan Huang, Qing Ling, Shihui Mao, Yu Qian, Wenle Ye, Fenglin Li, Jiajia Pan, Xiangjie Lin, Jiansong Huang, Xin Huang, Yifan Zhai, Jie Sun and Jie Jin
    Citation: Journal of Translational Medicine 2022 20:299

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