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  1. High morbidity and mortality due to carbapenem-resistant Gram-negative bacilli (CR-GNB) has led to the resurgence of polymyxin B (PMB) use in the last decade. The aim of our multicenter, real-world study was t...

    Authors: Xiaojuan Zhang, Shaoyan Qi, Xiaoguang Duan, Bing Han, Shuguang Zhang, Shaohua Liu, Haixu Wang, Haibo Zhang and Tongwen Sun

    Citation: Journal of Translational Medicine 2021 19:431

    Content type: Research

    Published on:

  2. Central itch syndrome has been previously described in conditions such as stroke. The neurophysiology of central itch syndrome has been investigated in non-human primates but remains incompletely understood.

    Authors: Luciano Furlanetti, Harutomo Hasegawa, Natasha Hulse, Rachael Morris-Jones and Keyoumars Ashkan

    Citation: Journal of Translational Medicine 2021 19:430

    Content type: Research

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  3. Colorectal cancer is one of the most common malignancy in the world. It has been reported that cancer stem cells (CSCs) serve as the primary drivers of tumorigenesis and tumor progression. There is an urgent n...

    Authors: Yifan Li, Jing Xun, Botao Wang, Yuan Ma, Lanqiu Zhang, Lei Yang, Ruifang Gao, Jun Guan, Tianyu Liu, Hejun Gao, Ximo Wang and Qi Zhang

    Citation: Journal of Translational Medicine 2021 19:429

    Content type: Research

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  4. In the ovarian follicle, the Theca Cells (TCs) have two main functions: preserving morphological integrity and, importantly, secreting steroid androgen hormones. TCs express the essential enzyme 17α-hydroxylas...

    Authors: Christian Secchi, Martina Belli, Tracy N. H. Harrison, Joseph Swift, CheMyong Ko, Antoni J. Duleba, Dwayne Stupack, R. Jeffrey Chang and Shunichi Shimasaki

    Citation: Journal of Translational Medicine 2021 19:428

    Content type: Research

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  5. The association between exposure to air pollution and sudden sensorineural hearing loss (SSNHL) has not been extensively discussed in the literature. Therefore, we conducted this nationwide study to evaluate t...

    Authors: Stella Chin-Shaw Tsai, Yi-Chao Hsu, Jung-Nien Lai, Ruey-Hwang Chou, Hueng-Chuen Fan, Frank Cheau-Feng Lin, Ruihong Zhang, Cheng-Li Lin and Kuang-Hsi Chang

    Citation: Journal of Translational Medicine 2021 19:424

    Content type: Research

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  6. This research aimed to investigate the expression and function of FAM83A in the proliferation and metastasis in head and neck squamous cell carcinoma (HNSCC). FAM83A mRNA and protein expressions in HNSCC were ...

    Authors: Huan Ji, Haiyang Song, Zeyu Wang, Pengfei Jiao, Jiani Xu, Xuan Li, Hongming Du, Heming Wu and Yi Zhong

    Citation: Journal of Translational Medicine 2021 19:423

    Content type: Research

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  7. The present study aimed to compare the efficacy and safety profiles of microspheres versus (vs.) polyvinyl alcohol (PVA) for bronchial artery embolization (BAE) treatment in patients with hemoptysis.

    Authors: Zhigang Fu, Xun Li, Fei Cai, Yinpeng Yuan, Xiaolin Zhang, Jingxia Qin and Yonghui Liang

    Citation: Journal of Translational Medicine 2021 19:422

    Content type: Research

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  8. Human milk is a vehicle for bioactive compounds and beneficial bacteria which promote the establishment of a healthy gut microbiome of newborns, especially of preterm infants. Pasteurized donor human milk (PDH...

    Authors: D. Mallardi, C. Tabasso, P. Piemontese, S. Morandi, T. Silvetti, F. Biscarini, P. Cremonesi, B. Castiglioni, V. Pica, M. Stuknyte, I. De Noni, O. Amato, N. Liotto, F. Mosca and P. Roggero

    Citation: Journal of Translational Medicine 2021 19:420

    Content type: Research

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  9. Cystic fibrosis (CF) patients present with a variety of symptoms, including mood and cognition deficits, in addition to classical respiratory, and autonomic issues. This suggests that brain injury, which can b...

    Authors: Bhaswati Roy, Marlyn S. Woo, Susana Vacas, Patricia Eshaghian, Adupa P. Rao and Rajesh Kumar

    Citation: Journal of Translational Medicine 2021 19:419

    Content type: Research

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  10. Integrating functional annotations into SNP-set association studies has been proven a powerful analysis strategy. Statistical methods for such integration have been developed for continuous and binary phenotyp...

    Authors: Haojie Lu, Yongyue Wei, Zhou Jiang, Jinhui Zhang, Ting Wang, Shuiping Huang and Ping Zeng

    Citation: Journal of Translational Medicine 2021 19:418

    Content type: Research

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  11. Clear cell renal cell carcinoma (ccRCC) is the most common malignant tumor of the kidney. New and reliable biomarkers are in urgent need for ccRCC diagnosis and prognosis. The CENP family is overexpressed in m...

    Authors: Qi Wang, Jiaju Xu, Zhiyong Xiong, Tianbo Xu, Jingchong Liu, Yuenan Liu, Jiaping Chen, Jian Shi, Yi Shou, Changjie Yue, Di Liu, Huageng Liang, Hongmei Yang, Xiong Yang and Xiaoping Zhang

    Citation: Journal of Translational Medicine 2021 19:417

    Content type: Research

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  12. In vitro oocyte maturation (IVM) is being increasingly approached in assisted reproductive technology (ART). This study aimed to evaluate the quality of embryos generated by in-vitro matured immature follicles...

    Authors: Jianhua Li, Jing Chen, Tiecheng Sun, Shuiwen Zhang, Tingting Jiao, Ri-Cheng Chian, Youzhu Li and Ye Xu

    Citation: Journal of Translational Medicine 2021 19:416

    Content type: Research

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  13. Immune checkpoint blockades (ICBs) therapy showed limited efficacy in ovarian cancer management. Increasing evidence indicated that conventional and targeted therapies could affect tumor-associated immune resp...

    Authors: Jinyu Meng, Jin Peng, Jie Feng, Jochen Maurer, Xiao Li, Yan Li, Shu Yao, Ran Chu, Xiyu Pan, Junting Li, Ting Zhang, Lu Liu, Qing Zhang, Zeng Yuan, Hualei Bu, Kun Song…

    Citation: Journal of Translational Medicine 2021 19:415

    Content type: Research

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  14. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Dobrin D. Draganov, Antonio F. Santidrian, Ivelina Minev, Duong Nguyen, Mehmet Okyay Kilinc, Ivan Petrov, Anna Vyalkova, Elliot Lander, Mark Berman, Boris Minev and Aladar A. Szalay

    Citation: Journal of Translational Medicine 2021 19:414

    Content type: Correction

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    The original article was published in Journal of Translational Medicine 2019 17:100

  15. The length of time for clinical improvement of patients with thymomatous myasthenia gravis (MG) after extended thymectomy is not clear. The purpose of this study was to determine the length of time after thyme...

    Authors: Zhu Haoshuai, Zou Jianyong, Yang Lei, Zeng Bo, Jiefei Xiao, Xin Zhang, Zhenguang Chen and Su Chunhua

    Citation: Journal of Translational Medicine 2021 19:413

    Content type: Research

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  16. Peritoneal dialysis (PD) is a form of dialysis to replace the function of kidney, that uses the peritoneum as a dialysis membrane to remove metabolites and water retained in the body. Vitamin D deficiency is p...

    Authors: Chi Zhang, Junsheng Wang, Xiaohui Xie and Dong Sun

    Citation: Journal of Translational Medicine 2021 19:411

    Content type: Research

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  17. Metabolism is one of the most complex cellular biochemical reactions, providing energy and substances for basic activities such as cell growth and proliferation. Early studies have shown that glucose is an imp...

    Authors: Beibei Luo, Xin Zhou, Qingming Tang, Ying Yin, Guangxia Feng, Shue Li and Lili Chen

    Citation: Journal of Translational Medicine 2021 19:410

    Content type: Review

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  18. The Wnt signaling pathway is core to the growth of bladder tumors. Epithelial-to-mesenchymal transition (EMT) is significant for bladder tumor metastasis. Nevertheless, the relationship between the Wnt signali...

    Authors: Siqing Sun, Yutao Wang, Jianfeng Wang and Jianbin Bi

    Citation: Journal of Translational Medicine 2021 19:409

    Content type: Research

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  19. Compared to the other members of human epidermal growth factor family receptors (HER), the role of HER3 has not been well defined in laryngeal cancer. The predictive and prognostic role of HER3 has been the fo...

    Authors: Giovanni Almadori, Antonella Coli, Eugenio De Corso, Dario Antonio Mele, Stefano Settimi, Giovanni Di Cintio, Francesca Brigato, Domenico Scannone, Thomas E. Carey, Gaetano Paludetti, Libero Lauriola and Franco Oreste Ranelletti

    Citation: Journal of Translational Medicine 2021 19:408

    Content type: Research

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  20. Authors: Xin Zhang, Xuehai Wang, Ran Xu, Jianxiong Ji, Yangyang Xu, Mingzhi Han, Yuzhen Wei, Bin Huang, Anjing Chen, Qing Zhang, Wenjie Li, Jian Wang, Xingang Li and Chen Qiu

    Citation: Journal of Translational Medicine 2021 19:407

    Content type: Correction

    Published on:

    The original article was published in Journal of Translational Medicine 2018 16:79

  21. Pelvic magnetic resonance imaging (MRI) and whole-body positron emission tomography-computed tomography (PET-CT) play an important role at primary diagnostic work-up and in detecting recurrent disease in endom...

    Authors: Heidi Espedal, Hege F. Berg, Tina Fonnes, Kristine E. Fasmer, Camilla Krakstad and Ingfrid S. Haldorsen

    Citation: Journal of Translational Medicine 2021 19:406

    Content type: Research

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  22. The lectin galactoside-binding soluble 3 binding protein (LGALS3BP) is a secreted, hyperglycosylated protein expressed by the majority of human cells. It was first identified as cancer and metastasis associate...

    Authors: Emily Capone, Stefano Iacobelli and Gianluca Sala

    Citation: Journal of Translational Medicine 2021 19:405

    Content type: Review

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  23. The molecular profiling of glioblastoma (GBM) based on transcriptomic analysis could provide precise treatment and prognosis. However, current subtyping (classic, mesenchymal, neural, proneural) is time-consum...

    Authors: Minjie Fu, Jinsen Zhang, Weifeng Li, Shan He, Jingwen Zhang, Daniel Tennant, Wei Hua and Ying Mao

    Citation: Journal of Translational Medicine 2021 19:404

    Content type: Research

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  24. Coronavirus disease 2019 (COVID-19) pandemic had a 1st wave in Europe from March to May 2020 and a 2nd wave since September 2020. We previously studied 35 hospitalized COVID-19 patients of the 1st wave demonst...

    Authors: Giulia Scalia, Maddalena Raia, Monica Gelzo, Sara Cacciapuoti, Annunziata De Rosa, Biagio Pinchera, Riccardo Scotto, Agnese Giaccone, Mauro Mormile, Gabriella Fabbrocini, Ivan Gentile, Roberto Parrella and Giuseppe Castaldo

    Citation: Journal of Translational Medicine 2021 19:403

    Content type: Research

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  25. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Yi Yang, Xiao He, Rongseng Zhao, Wei Guo, Ming Zhu, Wei Xing, Dongpo Jiang, Chongyang Liu and Xiang Xu

    Citation: Journal of Translational Medicine 2021 19:402

    Content type: Correction

    Published on:

    The original article was published in Journal of Translational Medicine 2018 16:165

  26. Poorly cohesive (PC) is a unique histologic subtype of gastric cancer (GC), with an increasing incidence in recent years. However, the molecular characteristics and therapeutic targets of PC GC are not yet wel...

    Authors: Yue Wang, Tao Shi, Xuan Wang, Jinwei Hu, Lixia Yu, Qin Liu, Nandie Wu, Baorui Liu and Jia Wei

    Citation: Journal of Translational Medicine 2021 19:401

    Content type: Research

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  27. Cancer stem cells (CSCs) are key regulators in the processes of tumor initiation, progression, and recurrence. The mechanism that maintains their stemness remains enigmatic, although the role of several long n...

    Authors: Yu-Shui Ma, Xiao-Li Yang, Yu-Shan Liu, Hua Ding, Jian-Jun Wu, Yi Shi, Cheng-You Jia, Gai-Xia Lu, Dan-Dan Zhang, Hui-Min Wang, Pei-Yao Wang, Fei Yu, Zhong-Wei Lv, Gao-Ren Wang, Ji-Bin Liu and Da Fu

    Citation: Journal of Translational Medicine 2021 19:400

    Content type: Research

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  28. This study aimed to recognize the hub genes associated with prognosis in follicular lymphoma (FL) treated with first-line rituximab combined with chemotherapy.

    Authors: Yu Zhou, Shasha Wang, Yunxia Tao, Haizhu Chen, Yan Qin, Xiaohui He, Shengyu Zhou, Peng Liu, Jianliang Yang, Sheng Yang, Lin Gui, Ning Lou, Zhishang Zhang, Jiarui Yao, Xiaohong Han and Yuankai Shi

    Citation: Journal of Translational Medicine 2021 19:399

    Content type: Research

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  29. The diversity and plasticity behind ER+/PR−/HER2− breast cancer have not been widely explored. It is essential to identify heterogeneous microenvironment phenotypes and investigate specific genomic events driv...

    Authors: Peiling Xie, Rui An, Shibo Yu, Jianjun He and Huimin Zhang

    Citation: Journal of Translational Medicine 2021 19:398

    Content type: Research

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  30. Painful vaso-occlusive crisis (VOC) remains the most common reason for presenting to the Emergency Department and hospitalization in patients with sickle cell disease (SCD). Although two new agents have been a...

    Authors: Tim Jang, Maria Poplawska, Emanuela Cimpeanu, George Mo, Dibyendu Dutta and Seah H. Lim

    Citation: Journal of Translational Medicine 2021 19:397

    Content type: Review

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  31. Recent studies have showed that IKBKE is overexpressed in several kinds of cancers and that IKBKE-knockdown inhibits tumor progression. In this article, we first verified that two glioblastoma cell lines, U87-...

    Authors: Xin Wang, Jie Lu, Jing Li, Yang Liu, Gaochao Guo and Qiang Huang

    Citation: Journal of Translational Medicine 2021 19:396

    Content type: Research

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  32. Restenosis after angioplasty is a major challenge for the treatment of coronary artery diseases. Facilitation of vascular smooth muscle cell (VSMC) apoptosis may be an attractive approach to decrease the incid...

    Authors: Xinxin Zhang, Xiangyu Xu, Li Lu, Xiaoning Wan, Yating Qin, Weibin Ruan, Chao Lv, Lin He and Xiaomei Guo

    Citation: Journal of Translational Medicine 2021 19:395

    Content type: Research

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  33. Sjogren’s syndrome (SS) is a heterogenous disease with various phenotypes. We aimed to provide a relevant subclassification based on symptom-based clustering for patients with primary (p) SS.

    Authors: Jennifer Jooha Lee, Young Jae Park, Misun Park, Hyeon Woo Yim, Sung Hwan Park and Seung-Ki Kwok

    Citation: Journal of Translational Medicine 2021 19:394

    Content type: Research

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  34. Sphingosine Kinase (SphK) that catalyzes sphingosine (Sph) to sphingosine 1-phosphate (S1P), plays a key role in both sphingolipid metabolism and cellular signaling. While SphK has been implicated in type 2 di...

    Authors: Qi Chen, Wei Wang, Ming-Feng Xia, You-li Lu, Hua Bian, Chen Yu, Xiao-Ying Li, Mathew A. Vadas, Xin Gao, Huan-Dong Lin and Pu Xia

    Citation: Journal of Translational Medicine 2021 19:393

    Content type: Research

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  35. Patients with rheumatoid arthritis (RA) have increased levels of interleukin-18 (IL-18) and decreased levels of IL-18 binding protein (IL-18BP) in the serum and synovial fluid (SF) compared to those in patient...

    Authors: Hong Ki Min, Sehee Kim, Ji-Yeon Lee, Kyoung-Woon Kim, Sang-Heon Lee and Hae-Rim Kim

    Citation: Journal of Translational Medicine 2021 19:392

    Content type: Research

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  36. EMT is an important biological process in the mechanism of tumor invasion and metastasis. However, there are still many unknowns about the specific mechanism of EMT in tumor. At present, a comprehensive analys...

    Authors: Yang Yang, Mingyang Feng, LiangLiang Bai, Weiting Liao, Kexun Zhou, Mengxi Zhang, Qiuji Wu, Feng Wen, Wanting Lei, Pengfei Zhang, Nan Zhang, Jiaxing Huang and Qiu Li

    Citation: Journal of Translational Medicine 2021 19:391

    Content type: Research

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  37. Lung adenocarcinoma (LUAD) is a common subtype of lung cancer with high recurrence rate and fatality. Circ_0001361 has been recognized as key regulators in various malignancies, but its roles in LUAD remain am...

    Authors: Hong-Yu Shen, Liu-Xi Shi, Lin Wang, Le-Ping Fang, Wei Xu, Ju-Qing Xu, Bo-Qiang Fan and Wei-Fei Fan

    Citation: Journal of Translational Medicine 2021 19:389

    Content type: Research

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  38. Acute myeloid leukemia (AML) is the most common acute leukemia in adults, with a median age of 68 in clinical diagnosis. About 60% patients are over 60 years old. There are various treatment options for AML pa...

    Authors: Jizhang Bao, Xinhua Zhao, Jiahui Lu, Zhaoyang Hu, Minghui Hu, Xiaoxia Hu, Libing Wang, Qi Hu, Weiling Sun, Jie Wang, Hailin Chen, Hao Lu, Changgui Li, Jing Xu, Yongming Zhou and Wenwei Zhu

    Citation: Journal of Translational Medicine 2021 19:388

    Content type: Research

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  39. The recurrence and metastasis of nasopharyngeal cancer (NPC) may be mainly attributed to the persistence of cancer stem cells (CSCs); however, the linkage mechanism has yet to be fully elucidated.

    Authors: Mengyang Zhao, Zibo Tang, Yijun Wang, Jiaojiao Ding, Ying Guo and Tianhui Gao

    Citation: Journal of Translational Medicine 2021 19:387

    Content type: Research

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  40. Little is known regarding the functional role of microRNA-193-3p (miR-193-3p) in sepsis. Hence, the aim of the present study was to investigate the effect of miR-193-3p on myocardial injury in mice with sepsis...

    Authors: Jianyuan Pan, Buse Alexan, Dorn Dennis, Chiristine Bettina, Laeuf Ilona Mariya Christoph and Yongqin Tang

    Citation: Journal of Translational Medicine 2021 19:386

    Content type: Research

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  41. Tumor heterogeneity is a primary cause of treatment failure. However, changes in drug sensitivity over time are not well mapped in cancer. Patient-derived organoids (PDOs) may predict clinical drug responses e...

    Authors: Kushtrim Kryeziu, Seyed H. Moosavi, Christian H. Bergsland, Marianne G. Guren, Peter W. Eide, Max Z. Totland, Kristoffer Lassen, Andreas Abildgaard, Arild Nesbakken, Anita Sveen and Ragnhild A. Lothe

    Citation: Journal of Translational Medicine 2021 19:384

    Content type: Research

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  42. Antiangiogenic therapy has increasingly become an important strategy for the treatment of colorectal cancer. Recent studies have shown that the tumour microenvironment (TME) promotes tumour angiogenesis. Bufal...

    Authors: Kai Fang, Yueping Zhan, Ruiqiu Zhu, Yuqian Wang, Chengqi Wu, Min Sun, Yanyan Qiu, Zeting Yuan, Xin Liang, Peihao Yin and Ke Xu

    Citation: Journal of Translational Medicine 2021 19:383

    Content type: Research

    Published on:

  43. Glycolysis affects tumor growth, invasion, chemotherapy resistance, and the tumor microenvironment. In this study, we aimed to construct a glycolysis-related prognostic model for ovarian cancer and analyze its...

    Authors: Jianlei Bi, Fangfang Bi, Xue Pan and Qing Yang

    Citation: Journal of Translational Medicine 2021 19:382

    Content type: Research

    Published on:

  44. Tumor-derived exosomes (TEXs) are involved in tumor progression and the immune modulation process and mediate intercellular communication in the tumor microenvironment. Although exosomes are considered promisi...

    Authors: Jiani Wu, Dongqiang Zeng, Shimeng Zhi, Zilan Ye, Wenjun Qiu, Na Huang, Li Sun, Chunlin Wang, Zhenzhen Wu, Jianping Bin, Yulin Liao, Min Shi and Wangjun Liao

    Citation: Journal of Translational Medicine 2021 19:381

    Content type: Research

    Published on:

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