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  1. Post-COVID-19 syndrome (PCS) shares many features with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). PCS represents a major health issue worldwide because it severely impacts patients’ work acti...

    Authors: Alaa Ghali, Valentin Lacombe, Camille Ravaiau, Estelle Delattre, Maria Ghali, Geoffrey Urbanski and Christian Lavigne
    Citation: Journal of Translational Medicine 2023 21:375
  2. Although mRNA vaccines have overall efficacy preventing morbidity/mortality from SARS-CoV-2 infection, immunocompromised persons remain at risk. Antibodies mostly prevent early symptomatic infection, but cellu...

    Authors: Ellie Taus, Michael Y. Shino, F. Javier Ibarrondo, Mary Ann Hausner, Christian Hofmann and Otto O. Yang
    Citation: Journal of Translational Medicine 2023 21:374
  3. The relationship between intestinal microbiome and colorectal cancer (CRC) progression is unclear. This study aims to identify the intestinal microbiome associated with CRC progression and construct predictive...

    Authors: Jungang Liu, Xiaoliang Huang, Chuanbin Chen, Zhen Wang, Zigui Huang, Mingjian Qin, Fuhai He, Binzhe Tang, Chenyan Long, Hong Hu, Shuibo Pan, Junduan Wu and Weizhong Tang
    Citation: Journal of Translational Medicine 2023 21:373
  4. Autism spectrum disorder (ASD) is a neurodevelopmental disorder that is difficult to diagnose. Inflammatory bowel disease (IBD) is a common chronic digestive disease. Previous studies have shown a potential co...

    Authors: Jinyi Zhu, Haoran Meng, Li Zhang and Yan Li
    Citation: Journal of Translational Medicine 2023 21:372
  5. The transcription factor family activator protein 2 (TFAP2) is vital for regulating both embryonic and oncogenic development. The TFAP2 family consists of five DNA-binding proteins, including TFAP2A, TFAP2B, T...

    Authors: Chen Jin, Yuxiao Luo, Zhu Liang, Xi Li, Damian Kołat, Linyong Zhao and Weixi Xiong
    Citation: Journal of Translational Medicine 2023 21:371
  6. Observational studies and conventional Mendelian randomization (MR) studies showed inconclusive evidence to support the association between omega-3 fatty acids and type 2 diabetes. We aim to evaluate the causa...

    Authors: Chunyan Hu, Yulin Zhou, Xueyan Wu, Xiaojing Jia, Yuanyue Zhu, Ruizhi Zheng, Shuangyuan Wang, Lin Lin, Hongyan Qi, Hong Lin, Mian Li, Tiange Wang, Zhiyun Zhao, Min Xu, Yu Xu, Yuhong Chen…
    Citation: Journal of Translational Medicine 2023 21:370
  7. Hepatocellular carcinoma (HCC) is the leading cause of cancer-related death in people, and a common primary liver cancer. Lacking early diagnosis and a high recurrence rate after surgical resection, systemic t...

    Authors: Yuan Fang, XiaoLi Zhang, HanFei Huang and Zhong Zeng
    Citation: Journal of Translational Medicine 2023 21:369
  8. Chimeric antigen receptor (CAR) T cell therapy is an exciting cell-based cancer immunotherapy. Unfortunately, CAR-T cell therapy is associated with serious toxicities such as cytokine release syndrome (CRS) an...

    Authors: Pamela Leland, Dhiraj Kumar, Sridhar Nimmagadda, Steven R. Bauer, Raj K. Puri and Bharat H. Joshi
    Citation: Journal of Translational Medicine 2023 21:367
  9. Epicardial adipose tissue (EAT) secretome induces fibrosis. Fibrosis, primarily extracellular matrix (ECM) produced by fibroblasts, creates a substrate for atrial fibrillation (AF). Whether the EAT secretome f...

    Authors: Eva R. Meulendijks, Rushd F. M. Al-Shama, Makiri Kawasaki, Benedetta Fabrizi, Jolien Neefs, Robin Wesselink, Auriane C. Ernault, Sander Piersma, Thang V. Pham, Connie R. Jimenez, Jaco C. Knol, Wim J. P. van Boven, Antoine H. G. Driessen, Tim A. C. de Vries, Britt van der Leeden, Hans W. M. Niessen…
    Citation: Journal of Translational Medicine 2023 21:366
  10. Silica-induced pulmonary fibrosis (silicosis) is a diffuse interstitial fibrotic disease characterized by the massive deposition of extracellular matrix in lung tissue. Fibroblast to myofibroblast differentiat...

    Authors: Yaqian Qu, Ruonan Zhai, Dandan Wang, Zheng Wang, Guangjie Hou, Chenchen Wu, Meian Tang, Xiongbin Xiao, Jie Jiao, Yue Ba, Fang Zhou, Jian Qiu and Wu Yao
    Citation: Journal of Translational Medicine 2023 21:365
  11. Gestational diabetes mellitus (GDM) is a common complication of pregnancy that has been associated with an increased risk of obesity and diabetes in the offspring. Pregnancy is accompanied by tightly regulated...

    Authors: Parul Singh, Duaa Ahmed Idris Elhaj, Ibrahim Ibrahim, Hala Abdullahi and Souhaila Al Khodor
    Citation: Journal of Translational Medicine 2023 21:364
  12. Cancer metabolism influences multiple aspects of tumorigenesis and causes diversity across malignancies. Although comprehensive research has extended our knowledge of molecular subgroups in medulloblastoma (MB...

    Authors: Viktoria L. E. Funke, Carolin Walter, Viktoria Melcher, Lanying Wei, Sarah Sandmann, Marc Hotfilder, Julian Varghese, Natalie Jäger, Marcel Kool, David T. W. Jones, Stefan M. Pfister, Till Milde, Martin Mynarek, Stefan Rutkowski, Jochen Seggewiss, Daniela Jeising…
    Citation: Journal of Translational Medicine 2023 21:363
  13. Reprogramming lipid metabolism for tumor metastasis is essential in breast cancer, and NUCB2/Nesfatin-1 plays a crucial role in regulating energy metabolism. Its high expression is associated with poor prognos...

    Authors: Siyi Ning, Caiying Liu, Kangtao Wang, Yubo Cai, Zhicheng Ning, Ming Li and Liang Zeng
    Citation: Journal of Translational Medicine 2023 21:362
  14. Restoration of salivary gland function in Sjogren’s syndrome (SS) is still a challenge. Dental pulp stem cells (DPSCs) derived exosomes had shown anti-inflammatory, anti-oxidative, immunomodulatory, and tissue...

    Authors: Shilin Hu, Bo Chen, Jiannan Zhou, Fangqi Liu, Tianjiao Mao, Janak L. Pathak, Nobumoto Watanabe and Jiang Li
    Citation: Journal of Translational Medicine 2023 21:361
  15. Novel human epidermal growth factor receptor 2 (HER2)-directed antibody–drug conjugates prompt the identification of the HER2-low subtype. However, the biological significance of HER2-low expression in breast ...

    Authors: Juan Jin, Bin Li, Jianing Cao, Ting Li, Jian Zhang, Jun Cao, Mingchuan Zhao, Leiping Wang, Biyun Wang, Zhonghua Tao and Xichun Hu
    Citation: Journal of Translational Medicine 2023 21:360
  16. Chronic kidney disease (CKD) is one of the most significant cardiovascular risk factors, playing vital roles in various cardiovascular diseases such as calcific aortic valve disease (CAVD). We aim to explore t...

    Authors: Enyi Zhu, Xiaorong Shu, Zi Xu, Yanren Peng, Yunxiu Xiang, Yu Liu, Hui Guan, Ming Zhong, Jinhong Li, Li-Zhen Zhang, Ruqiong Nie and Zhihua Zheng
    Citation: Journal of Translational Medicine 2023 21:359
  17. The distribution of ACE2 and accessory proteases (ANAD17 and CTSL) in cardiovascular tissue and the host cell receptor binding of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are crucial to und...

    Authors: Cong Chen, Jie Wang, Yong-Mei Liu and Jun Hu
    Citation: Journal of Translational Medicine 2023 21:358
  18. Osteoarthritis (OA) is one of the most prevalent musculoskeletal diseases and is the leading cause of pain and disability in the aged population. However, the underlying biological mechanism has not been fully...

    Authors: Yifei Gu, Qianmei Jin, Jinquan Hu, Xinwei Wang, Wenchao Yu, Zhanchao Wang, Chen Wang, Yang Liu, Yu Chen and Wen Yuan
    Citation: Journal of Translational Medicine 2023 21:357
  19. Circular RNAs (circRNAs) are known to play a crucial role in a variety of malignancies. However, the precise role of circRNAs in cervical squamous cell carcinoma (CSCC) remains largely unknown.

    Authors: Wei Wang, Haixia Luo, Jingjing Chang, Xin Yang, Xiu Zhang, Qingmei Zhang, Yuanxing Li, Yueyang Zhao, Jianbing Liu, Binbin Zou and Min Hao
    Citation: Journal of Translational Medicine 2023 21:356
  20. Higher vitamin D concentrations and grip strength contribute to lower individual-level risk of dementia, while apolipoprotein 4 (APOE e4) genotype carries increases dementia risk, but whether combination of id...

    Authors: Jiangtao Feng, Qi Wang and Yuan Zhang
    Citation: Journal of Translational Medicine 2023 21:355
  21. Lipid A is the primary immunostimulatory part of the lipopolysaccharide (LPS) molecule. The inflammatory response of LPS varies and depends upon the number of acyl chains and phosphate groups in lipid A which ...

    Authors: Maryia Khomich, Huang Lin, Andrei Malinovschi, Susanne Brix, Lucia Cestelli, Shyamal Peddada, Ane Johannessen, Carsten Eriksen, Francisco Gomez Real, Cecilie Svanes and Randi Jacobsen Bertelsen
    Citation: Journal of Translational Medicine 2023 21:354
  22. Carotid atherosclerosis (CAS), an important factor in the development of stroke, is a major public health concern. The aim of this study was to establish and validate machine learning (ML) models for early scr...

    Authors: Ke Yun, Tao He, Shi Zhen, Meihui Quan, Xiaotao Yang, Dongliang Man, Shuang Zhang, Wei Wang and Xiaoxu Han
    Citation: Journal of Translational Medicine 2023 21:353
  23. The cerebellum plays key roles in the pathology of multiple sclerosis (MS) and neuromyelitis optica spectrum disorder (NMOSD), but the way in which these conditions affect how the cerebellum communicates with ...

    Authors: Yuping Yang, Junle Li, Ting Li, Zhen Li, Zhizheng Zhuo, Xuemei Han, Yunyun Duan, Guanmei Cao, Fenglian Zheng, Decai Tian, Xinli Wang, Xinghu Zhang, Kuncheng Li, Fuqing Zhou, Muhua Huang, Yuxin Li…
    Citation: Journal of Translational Medicine 2023 21:352
  24. The current ageing trend of the world population has, in part, accounted for Alzheimer disease (AD) being a public health issue in recent times. Although some progress has been made in clarifying AD-related pa...

    Authors: Benson O. A. Botchway, Xuehong Liu, Yu Zhou and Marong Fang
    Citation: Journal of Translational Medicine 2023 21:351
  25. Glioblastoma multiforme (GBM) is associated with remarkably poor prognosis, and its treatment is challenging. This investigation aimed to evaluate the safety of suicide gene therapy using allogeneic adipose ti...

    Authors: Saeed Oraee-Yazdani, Roozbeh Tavanaei, Fatemeh Rostami, Atieh Hajarizadeh, Marzieh Mehrabadi, Mohammadhosein Akhlaghpasand, Mona Tamaddon, Samin Khannejad, Kaveh Oraii Yazdani and Alireza Zali
    Citation: Journal of Translational Medicine 2023 21:350
  26. Gut microbiota is closely related to human health and disease because, together with their metabolites, gut microbiota maintain normal intestinal peristalsis. The use of antibiotics or opioid anesthetics, or b...

    Authors: TianRong Ma, XiaoLei Xue, Hui Tian, XinXiu Zhou, JunKe Wang, ZhiWen Zhao, MingFei Wang, JiYuan Song, RenXiang Feng, Leping Li, Changqing Jing and Feng Tian
    Citation: Journal of Translational Medicine 2023 21:349
  27. Cardiovascular disease (CVD) is the leading cause of noncommunicable disease-related death worldwide, and effective therapeutic strategies against CVD are urgently needed. Mitochondria dysfunction involves in ...

    Authors: Mingchu Sun, Wenhua Jiang, Nan Mu, Zihui Zhang, Lu Yu and Heng Ma
    Citation: Journal of Translational Medicine 2023 21:347
  28. Bispecific antibody has garnered considerable attention in the recent years due to its impressive preliminary efficacy in hematological malignancies. For solid tumors, however, the main hindrance is the suppre...

    Authors: Po-Lin Huang, Hung-Tsai Kan, Ching-Hsuan Hsu, Hsin-Ta Hsieh, Wan-Chien Cheng, Ren-Yeong Huang and Jhong-Jhe You
    Citation: Journal of Translational Medicine 2023 21:346
  29. Malignant melanoma is one of the most common tumours and has the highest mortality rate of all types of skin cancers worldwide. Traditional and novel therapeutic approaches, including surgery, targeted therapy...

    Authors: Fei Du, Lu-han Yang, Jiao Liu, Jian Wang, Lianpeng Fan, Suwit Duangmano, Hao Liu, Minghua Liu, Jun Wang, Xiaolin Zhong, Zhuo Zhang and Fang Wang
    Citation: Journal of Translational Medicine 2023 21:345
  30. As leading contributors to worldwide morbidity and mortality, sepsis and septic shock are considered a major global health concern. Proactive biomarker identification in patients with sepsis suspicion at any t...

    Authors: José Luis García-Giménez, Eva García-López, Salvador Mena-Mollá, Jesús Beltrán-García, Rebeca Osca-Verdegal, Elena Nacher-Sendra, Carmen Aguado-Velasco, Germán Casabó-Vallés, Carlos Romá-Mateo, María Rodriguez-Gimillo, Oreto Antúnez, José Ferreres, Federico V. Pallardó and Nieves Carbonell
    Citation: Journal of Translational Medicine 2023 21:344
  31. Clear cell renal cell carcinoma (ccRCC) is a highly invasive and metastatic subtype of kidney malignancy and is correlated with metabolic reprogramming for adaptation to the tumor microenvironment comprising i...

    Authors: Hansen Lin, Liangmin Fu, Pengju Li, Jiangquan Zhu, Quanhui Xu, Yinghan Wang, Mukhtar Adan Mumin, Xinwei Zhou, Yuhang Chen, Guannan Shu, Gaosheng Yao, Minyu Chen, Jun Lu, Lizhen Zhang, YuJun Liu, Yiqi Zhao…
    Citation: Journal of Translational Medicine 2023 21:343
  32. The Swedish Childhood Tumor Biobank (BTB) is a nonprofit national infrastructure for collecting tissue samples and genomic data from pediatric patients diagnosed with central nervous system (CNS) and other sol...

    Authors: Teresita Díaz de Ståhl, Alia Shamikh, Markus Mayrhofer, Szilvester Juhos, Elisa Basmaci, Gabriela Prochazka, Maxime Garcia, Praveen Raj Somarajan, Katarzyna Zielinska-Chomej, Christopher Illies, Ingrid Øra, Peter Siesjö, Per-Erik Sandström, Jakob Stenman, Magnus Sabel, Bengt Gustavsson…
    Citation: Journal of Translational Medicine 2023 21:342
  33. Immunocheckpoint inhibitors (ICIs) have been widely used in the clinical treatment of lung cancer. Although clinical studies and trials have shown that patients can benefit significantly after PD-1/PD-L1 block...

    Authors: Tongyuan Qu, Wenshuai Zhang, Chenhui Yan, Danyang Ren, Yalei Wang, Yuhong Guo, Qianru Guo, Jinpeng Wang, Liren Liu, Lei Han, Lingmei Li, Qiujuan Huang, Lu Cao, Zhaoxiang Ye, Bin Zhang, Qiang Zhao…
    Citation: Journal of Translational Medicine 2023 21:341
  34. We previously demonstrated that an Italian family affected by a severe dilated cardiomyopathy (DCM) with history of sudden deaths at young age, carried a mutation in the Lmna gene encoding for a truncated variant...

    Authors: Giusy Pietrafesa, Roberta De Zio, Simona Ida Scorza, Maria Francesca Armentano, Martino Pepe, Cinzia Forleo, Giuseppe Procino, Andrea Gerbino, Maria Svelto and Monica Carmosino
    Citation: Journal of Translational Medicine 2023 21:340
  35. Disruption of N6 methyl adenosine (m6A) modulation hampers gene expression and cellular functions, leading to various illnesses. However, the role of m6A modification in osteoarthritis (OA) synovitis remains u...

    Authors: Yuheng Lu, Hongbo Zhang, Haoyan Pan, Zhicheng Zhang, Hua Zeng, Haoyu Xie, Jianbin Yin, Wen Tang, Rengui Lin, Chun Zeng and Daozhang Cai
    Citation: Journal of Translational Medicine 2023 21:339
  36. To evaluate a new class of blood-based biomarkers, anti-frameshift peptide antibodies, for predicting both tumor responses and adverse immune events to immune checkpoint inhibitor (ICI) therapies in advanced l...

    Authors: Luhui Shen, Justin R. Brown, Stephen Albert Johnston, Mehmet Altan and Kathryn F. Sykes
    Citation: Journal of Translational Medicine 2023 21:338
  37. To explore an optimal model to predict the response of patients with axillary lymph node (ALN) positive breast cancer to neoadjuvant chemotherapy (NAC) with machine learning using clinical and ultrasound-based...

    Authors: Hao Zhang, Wen Cao, Lianjuan Liu, Zifan Meng, Ningning Sun, Yuanyuan Meng and Jie Fei
    Citation: Journal of Translational Medicine 2023 21:337
  38. Depending on the needs of scientific research at a given time, biobanks make biological samples and data available to researchers. In this article, we aim to describe the reasons and underlying logic that dete...

    Authors: Desprès Caroline and Mamzer Marie-France
    Citation: Journal of Translational Medicine 2023 21:336
  39. Interleukin-17A (IL-17A), a proinflammatory cytokine primarily secreted by Th17 cells, γδT cells and natural killer T (NKT) cells, performs essential roles in the microenvironment of certain inflammation-relat...

    Authors: Wen-Qing Feng, Yu-Chen Zhang, Zhuo-Qing Xu, Su-Yue Yu, Jian-ting Huo, Abudumaimaitijiang Tuersun, Min-Hua Zheng, Jing-Kun Zhao, Ya-Ping Zong and Ai-Guo Lu
    Citation: Journal of Translational Medicine 2023 21:335
  40. Ovarian cancer (OC) has high mortality and poor prognosis for lacking of specific biomarkers and typical clinical symptoms in the early stage. CEBPG is an important regulator in tumor development, yet it is un...

    Authors: Xiaoqian Zhang, Xiaocui Zheng, Xiang Ying, Weiwei Xie, Yujia Yin and Xipeng Wang
    Citation: Journal of Translational Medicine 2023 21:334
  41. Despite numerous clinical trials and decades of endeavour, there is still no effective cure for Alzheimer's disease. Computational drug repositioning approaches may be employed for the development of new treat...

    Authors: Abdulahad Bayraktar, Xiangyu Li, Woonghee Kim, Cheng Zhang, Hasan Turkez, Saeed Shoaie and Adil Mardinoglu
    Citation: Journal of Translational Medicine 2023 21:332
  42. People with mitochondrial disease (MtD) are susceptible to metabolic decompensation and neurological symptom progression in response to an infection. Increasing evidence suggests that mitochondrial dysfunction...

    Authors: Emily B. Warren, Eliza M. Gordon-Lipkin, Foo Cheung, Jinguo Chen, Amrita Mukherjee, Richard Apps, John S. Tsang, Jillian Jetmore, Melissa L. Schlein, Shannon Kruk, Yuanjiu Lei, A. Phillip West and Peter J. McGuire
    Citation: Journal of Translational Medicine 2023 21:331
  43. Spatial transcriptomics technologies developed in recent years can provide various information including tissue heterogeneity, which is fundamental in biological and medical research, and have been making sign...

    Authors: Jun Du, Yu-Chen Yang, Zhi-Jie An, Ming-Hui Zhang, Xue-Hang Fu, Zou-Fang Huang, Ye Yuan and Jian Hou
    Citation: Journal of Translational Medicine 2023 21:330
  44. The success of allogeneic hematopoietic stem cell transplant for hematological malignancies is heavily dependent on the availability of suitable donors. Haploidentical donor (HID) and matched sibling donor (MS...

    Authors: Hengwei Wu, Yeqian Zhao, Fei Gao, Jimin Shi, Yi Luo, Jian Yu, Xiaoyu Lai, Lizhen Liu, Huarui Fu, Pengxu Qian, He Huang and Yanmin Zhao
    Citation: Journal of Translational Medicine 2023 21:329
  45. Oral squamous cell carcinoma (OSCC) is one of the most prevalent and fatal oral cancers. Mitochondria-targeting therapies represent promising strategies against various cancers, but their applications in treat...

    Authors: Yafei Zhang, Bingqian Yang, Chengwei Tu, Yifan Ping, Shuhong Chen, Tong Wu, Zheyu Zhao, Yixin Mao, Zhan Yang, Zelin Cao, Jianmin Li, Kate Huang, Xi Ding, Gang Wu, Peng Zou, Zhennan Deng…
    Citation: Journal of Translational Medicine 2023 21:328
  46. The pathogenesis of osteoporosis involves multiple factors, among which alterations in the bone microenvironment play a crucial role in disrupting normal bone metabolic balance. Transient receptor potential va...

    Authors: Zhi-heng Luo, Jian-xiong Ma, Wei Zhang, Ai-xian Tian, Shu-wei Gong, Yan Li, Yu-xiao Lai and Xin-long Ma
    Citation: Journal of Translational Medicine 2023 21:327
  47. Renal tubulointerstitial fibrosis is the hallmark of various chronic kidney diseases. Symmetric dimethylarginine (SDMA) is an independent cardiovascular risk factor in patients with chronic kidney diseases, wh...

    Authors: Yanzhe Wang, Ming Wu, Dongping Chen, Bo Tan, Pinglan Lin, Di Huang and Chaoyang Ye
    Citation: Journal of Translational Medicine 2023 21:326

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