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  1. Antibody technology is widely used in the fields of biomedical and clinical therapies. Nonetheless, the complex in vitro expression of recombinant proteins, long production cycles, and harsh storage conditions...

    Authors: Yuxiang Zhao, Linchuan Gan, Dangjin Ke, Qi Chen and Yajuan Fu
    Citation: Journal of Translational Medicine 2023 21:693
  2. Migraine is the second world’s cause of disability. Among non-pharmacological treatments, nutritional intervention, particularly ketogenic diet, represents one of the most promising approaches.

    Authors: Massimiliano Caprio, Eleonora Moriconi, Elisabetta Camajani, Alessandra Feraco, Vincenzo Marzolla, Laura Vitiello, Stefania Proietti, Andrea Armani, Stefania Gorini, Caterina Mammi, Gabriella Egeo, Cinzia Aurilia, Giulia Fiorentini, Carlo Tomino and Piero Barbanti
    Citation: Journal of Translational Medicine 2023 21:692
  3. Metabolic syndrome (MetS), a worldwide public health problem, affects human health and quality of life in a dramatic manner. A growing evidence base suggests that MetS is strongly associated with levels of sys...

    Authors: Yang Zhao, Wenyu Shao, Qihan Zhu, Rui Zhang, Tao Sun, Bijia Wang and Xiaofei Hu
    Citation: Journal of Translational Medicine 2023 21:691
  4. Systemic administration of oncolytic adenovirus for cancer therapy is still a challenge. Mesenchymal stem cells as cell carriers have gained increasing attention in drug delivery due to their excellent tumor t...

    Authors: Xu He, Wei Yao, Ji-Ding Zhu, Xin Jin, Xin-Yuan Liu, Kang-Jian Zhang and Shou-Liang Zhao
    Citation: Journal of Translational Medicine 2023 21:688
  5. Two versions of Framingham’s 10-year risk score are defined for cardiovascular diseases, namely laboratory-based and office-based models. The former is mainly employed in high-income countries, but unfortunate...

    Authors: Azizallah Dehghan, Sajjad Ahmadnia Motlagh, Rozhan Khezri, Fatemeh Rezaei and Dagfinn Aune
    Citation: Journal of Translational Medicine 2023 21:687
  6. Cancer stem cells (CSCs) have emerged as key contributors to tumor initiation, growth, and metastasis. In addition, CSCs play a significant role in inducing immune evasion, thereby compromising the effectivene...

    Authors: Yan-Ruide Li, Ying Fang, Zibai Lyu, Yichen Zhu and Lili Yang
    Citation: Journal of Translational Medicine 2023 21:686
  7. Non-muscle invasive bladder cancer (NMIBC) is known for its elevated recurrence rate, necessitating an enhancement in the current risk stratification for recurrence. The urine-based fluorescence in situ hybrid...

    Authors: Junjiong Zheng, Sihong Lu, Yi Huang, Xu Chen, Jie Zhang, Yuhui Yao, Jinhua Cai, Jieying Wu, Jianqiu Kong and Tianxin Lin
    Citation: Journal of Translational Medicine 2023 21:685
  8. There is little prospective evidence exists about whether adherence to a diabetes risk reduction diet (DRRD) is related to a significant reduction in renal cancer risk. We sought to clarify whether adherence t...

    Authors: Ling Xiang, Yi Xiao, Zhiquan Xu, Haoyun Luo, Xiaorui Ren, Qi Wei, Zhiyong Zhu, Yahui Jiang, Yunhao Tang, Hongmei He, Zhihang Zhou, Haitao Gu, Yaxu Wang and Linglong Peng
    Citation: Journal of Translational Medicine 2023 21:684
  9. Recent progress in cancer immunotherapy encourages the expansion of chimeric antigen receptor (CAR) T cell therapy in solid tumors including hepatocellular carcinoma (HCC). Overexpression of MET receptor tyros...

    Authors: Anna Qin, Yuan Qin, Joseph Lee, Anna Musket, Mingyao Ying, Giedre Krenciute, Francesco M. Marincola, Zhi Q. Yao, Phillip R. Musich and Qian Xie
    Citation: Journal of Translational Medicine 2023 21:682
  10. Previous studies have assessed the association between antidiabetic drugs and stroke risk, but the results are inconsistent. Mendelian randomization (MR) was used to assess effects of antidiabetic drugs on str...

    Authors: Yahui Zhu, Mao Li, Hongfen Wang, Fei Yang, Xinyuan Pang, Rongrong Du, Jinghong Zhang and Xusheng Huang
    Citation: Journal of Translational Medicine 2023 21:681
  11. Metagenomic next-generation sequencing (mNGS) has become a powerful tool for pathogen detection, but the value of human sequencing reads generated from it is underestimated.

    Authors: Fudong Xu, Qingfeng Wang, Nana Zhang, Xuya Xing, Zichen Liu, Kun Li, Yutong Ma, Qiuxiang Ou, Yaqiong Jia, Xuejing Chen, Chen Zhang, Junhua Pan and Nanying Che
    Citation: Journal of Translational Medicine 2023 21:680
  12. Radiotherapy can cause kidney injury in patients with cervical cancer. This study aims to investigate the possible molecular mechanisms by which CpG-ODNs (Cytosine phosphate guanine-oligodeoxynucleotides) regu...

    Authors: Deyu Zhang, Shitai Zhang, Zheng He and Ying Chen
    Citation: Journal of Translational Medicine 2023 21:679
  13. Psoriasis is an inflammatory disease mediated by helper T (Th)17 and Th1 cells. MicroRNA-125a (miR-125a) is reduced in the lesional skin of psoriatic patients. However, the mechanism by which miR-125a particip...

    Authors: Kexiang Yan, Fuxin Zhang, Jie Ren, Qiong Huang, Nikhil Yawalkar and Ling Han
    Citation: Journal of Translational Medicine 2023 21:678
  14. Due to environmental hypoxia on the Tibetan Plateau, local residents often exhibit a compensative increase in hemoglobin concentration to maintain the body’s oxygen supply. However, increases in hemoglobin and...

    Authors: Xiaodong Wu, Zhijuan Liu, Doudou Hao, Qin Zhao, Wanjing Li, Maodi Xie, Xia Feng, Xia Liao, Siyuan Chen, Siyu Wang, Chaohua Zhou, Wenchun Long, Yajun Zhong, Shen Li, Ye Cao, Hong Wang…
    Citation: Journal of Translational Medicine 2023 21:676
  15. The terms metabolically healthy obesity (MHO) and metabolically unhealthy obesity (MUO) categorize subjects with obesity based on the presence or absence of cardio-metabolic risk factors. Detecting MUO phenoty...

    Authors: Luigi Barrea, Ludovica Verde, Daniel Simancas-Racines, Ana Karina Zambrano, Evelyn Frias-Toral, Annamaria Colao, Silvia Savastano and Giovanna Muscogiuri
    Citation: Journal of Translational Medicine 2023 21:675
  16. Recent research has established the correlation between gut microbiota and periodontitis via oral-gut axis. Intestinal dysbiosis may play a pivotal bridging role in extra-oral inflammatory comorbidities caused...

    Authors: Xinjian Ye, Bin Liu, Yijing Bai, Yue Cao, Sirui Lin, Linshuoshuo Lyu, Haohao Meng, Yuwei Dai, Ding Ye, Weiyi Pan, Zhiyong Wang, Yingying Mao and Qianming Chen
    Citation: Journal of Translational Medicine 2023 21:674
  17. Authors: Daniela Boselli, Maddalena Panigada, Simona Di Terlizzi, Monica Romanò, Emanuele Canonico, Chiara Villa, Claudia Minici, Eelco van Anken, Elisa Soprana and Antonio G. Siccardi
    Citation: Journal of Translational Medicine 2023 21:673

    The original article was published in Journal of Translational Medicine 2023 21:495

  18. Glioblastoma (GBM) is a highly aggressive primary brain tumor with a poor prognosis. This study investigates the therapeutic potential of human Vγ9Vδ2 T cells in GBM treatment. The sensitivity of different gli...

    Authors: Yi Wang, Nan Ji, Yang Zhang, Junsheng Chu, Changcun Pan, Peng Zhang, Weiwei Ma, Xueguang Zhang, Jianzhong Jeff Xi, Mingze Chen, Yonghui Zhang, Liwei Zhang and Tao Sun
    Citation: Journal of Translational Medicine 2023 21:672
  19. This study aims to comprehensively investigate the phenotypic and genetic relationships between four common lipids (high-density lipoprotein cholesterol, HDL-C; low-density lipoprotein cholesterol, LDL-C; tota...

    Authors: Yutong Wang, Li Zhang, Wenqiang Zhang, Mingshuang Tang, Huijie Cui, Xueyao Wu, Xunying Zhao, Lin Chen, Peijing Yan, Chao Yang, Chenghan Xiao, Yanqiu Zou, Yunjie Liu, Ling Zhang, Chunxia Yang, Yuqin Yao…
    Citation: Journal of Translational Medicine 2023 21:671
  20. Gastric cancer (GC) is a fatal cancer with unclear pathogenesis. In this study, we explored the function and potential mechanisms of intercellular adhesion molecule 2 (ICAM2) in the development and advancement...

    Authors: Xiaocheng Tang, Jintuan Huang, Yingming Jiang, Jun Qiu, Tuoyang Li, Weiyao Li, Zijian Chen, Zhenze Huang, Xihu Yu, Tao Yang, Xiang Ji, Rongchang Tan, Li lv, Zuli Yang and Hao Chen
    Citation: Journal of Translational Medicine 2023 21:670
  21. Plant-based dietary patterns may affect colorectal cancer (CRC) related outcomes, while risks differ in the quality of plant foods. We aimed to examine the association of plant-based diet quality with risks of...

    Authors: Fubin Liu, Yanling Lv, Yu Peng, Yating Qiao, Peng Wang, Changyu Si, Xixuan Wang, Jianxiao Gong, Huijun Zhou, Ming Zhang, Liangkai Chen and Fangfang Song
    Citation: Journal of Translational Medicine 2023 21:669
  22. Osteoporosis is a systemic bone disease characterized by low bone mass, microarchitectural deterioration, increased bone fragility, and fracture susceptibility. It commonly occurs in older people, especially p...

    Authors: Dong Wu, Lei Li, Zhun Wen and Guangbin Wang
    Citation: Journal of Translational Medicine 2023 21:668
  23. Spinal cord glioma (SCG) is considered an orphan disease that lacks effective treatment options with margins that are surgically inaccessible and an overall paucity of literature on the topic. The tumor microe...

    Authors: Muhibullah S. Tora, Stewart G. Neill, Yuliya Lakhina, Hemza Assed, Michelle Zhang, Purva P. Nagarajan, Thais Federici, Juanmarco Gutierrez, Kimberly B. Hoang, Yuhong Du, Kecheng Lei and Nicholas M. Boulis
    Citation: Journal of Translational Medicine 2023 21:667
  24. Heart diseases are among the leading causes of death worldwide, many of which lead to pathological cardiomyocyte hypertrophy and capillary rarefaction in both patients and animal models, the quantification of ...

    Authors: Patrick Droste, Dickson W. L. Wong, Mathias Hohl, Saskia von Stillfried, Barbara M. Klinkhammer and Peter Boor
    Citation: Journal of Translational Medicine 2023 21:666
  25. Ubiquitination is one of the most significant post-translational modifications that regulate almost all physiological processes like cell proliferation, autophagy, apoptosis, and cell cycle progression. Contra...

    Authors: Kaiyi Niu, Yanlong Shi, Qingpeng Lv, Yizhu Wang, Jiping Chen, Wenning Zhang, Kung Feng and Yewei Zhang
    Citation: Journal of Translational Medicine 2023 21:665
  26. Rapid identification of high-risk polytrauma patients is crucial for early intervention and improved outcomes. This study aimed to develop and validate machine learning models for predicting 72 h mortality in ...

    Authors: Wen He, Xianghong Fu and Song Chen
    Citation: Journal of Translational Medicine 2023 21:664
  27. Stem cell products are increasingly entering early stage clinical trials for treating retinal degeneration. The field is learning from experience about comparability of cells proposed for preclinical and clini...

    Authors: Bin Lu, Pablo Avalos, Soshana Svendsen, Changqing Zhang, Laura Nocito, Melissa K. Jones, Cosmo Pieplow, Joshua Saylor, Sean Ghiam, Amanda Block, Michael Fernandez, Alexander V. Ljubimov, Kent Small, David Liao, Clive N. Svendsen and Shaomei Wang
    Citation: Journal of Translational Medicine 2023 21:650
  28. There is evidence of pre-established vulnerability in individuals that increases the risk of their progression to severe disease or death, although the mechanisms causing this are still not fully understood. P...

    Authors: Felix Keller, Joachim Beige, Justyna Siwy, Alexandre Mebazaa, Dewei An, Harald Mischak, Joost P. Schanstra, Marika Mokou, Paul Perco, Jan A. Staessen, Antonia Vlahou and Agnieszka Latosinska
    Citation: Journal of Translational Medicine 2023 21:663
  29. Sodium–glucose cotransporter 2 (SGLT2) inhibitors constitute the gold standard treatment for type 2 diabetes mellitus (T2DM). Among them, empagliflozin (EMPA) has shown beneficial effects against heart failure...

    Authors: Lucia Scisciola, Ugo Chianese, Vicky Caponigro, Manuela Giovanna Basilicata, Emanuela Salviati, Lucia Altucci, Pietro Campiglia, Giuseppe Paolisso, Michelangela Barbieri, Rosaria Benedetti and Eduardo Sommella
    Citation: Journal of Translational Medicine 2023 21:662
  30. The prevention and treatment of osteoarthritis (OA) pose a major challenge in its research. The synovium is a critical tissue in the systematic treatment of OA. The present study aimed to investigate potential...

    Authors: Zhuangzhuang Jin, He Zhang, Lunhao Bai, Lingyu Yue, Weiming Zhang, Jiajian Liang, Bohan Chang, Yue Yang, Zhehan Hu, Liang Chen and Chuanji Guo
    Citation: Journal of Translational Medicine 2023 21:661
  31. Intracranial aneurysms (IAs) pose a significant and intricate challenge. Elucidating the interplay between DNA methylation and IA pathogenesis is paramount to identify potential biomarkers and therapeutic inte...

    Authors: Aierpati Maimaiti, Mirzat Turhon, Aimitaji Abulaiti, Yilidanna Dilixiati, Fujunhui Zhang, Aximujiang Axieer, Kaheerman Kadeer, Yisen Zhang, Aisha Maimaitili and Xinjian Yang
    Citation: Journal of Translational Medicine 2023 21:660
  32. Oncogene MYCN is closely related with malignant progression and poor prognosis of neuroblastoma (NB). Recently, long non-coding RNAs (lncRNAs) have been recognized as crucial regulators in various cancers. Howeve...

    Authors: Rui Yang, Nanjing Liu, Ting Li, Fangjie Liu, Jun Zhang, Hui Zhao, Lin Zou and Xiaoyan He
    Citation: Journal of Translational Medicine 2023 21:659
  33. Low serum selenium and altered tumour RNA expression of certain selenoproteins are associated with a poor breast cancer prognosis. Selenoprotein expression stringently depends on selenium availability, hence c...

    Authors: Kamil Demircan, Ylva Bengtsson, Thilo Samson Chillon, Johan Vallon-Christersson, Qian Sun, Christer Larsson, Martin Malmberg, Lao H. Saal, Lisa Rydén, Åke Borg, Jonas Manjer and Lutz Schomburg
    Citation: Journal of Translational Medicine 2023 21:658
  34. Increasing evidence has linked the thyroid dysfunction to the pathogenesis of dementia. Evidence from clinical studies has demonstrated that hypothyroidism is related to an increased risk of dementia. But the ...

    Authors: Kai Lou, Shudong Liu, Fengxia Zhang, Wenxiu Sun, Xinhuan Su, Wenkai Bi, Qingqing Yin, Yaxin Qiu, Zhenyuan Zhang, Mengzhe Jing and Shizhan Ma
    Citation: Journal of Translational Medicine 2023 21:657
  35. The catenin beta 1 gene (CTNNB1) plays a crucial role in the malignant progression of various cancers. Recent studies have suggested that CTNNB1 hyperactivation is closely related to the occurrence and develop...

    Authors: Tao Liu, Meng-Qi Fan, Xiao-Xiao Xie, Qi-Peng Shu, Xue-Hua Du, Lin-Zhi Qi, Xiao-Dong Zhang, Ming-Hui Zhang, Guang Shan, Run-Lei Du and Shang-Ze Li
    Citation: Journal of Translational Medicine 2023 21:656
  36. The chimeric antigen receptor (CAR)-T therapy has a limited therapeutic effect on solid tumors owing to the limited CAR-T cell infiltration into solid tumors and the inactivation of CAR-T cells by the immunosu...

    Authors: Yizhao Chen, Xiangling Zhu, Hanze Liu, Cunzhi Wang, Yu Chen, Huihui Wang, Yilong Fang, Xuming Wu, Yuting Xu, Chunhua Li, Xinyue Lv, Jinghua Huang, Xintong Han, Ruilin Li, Wenming Hong, Zhiying Yu…
    Citation: Journal of Translational Medicine 2023 21:654
  37. Kaposi sarcoma (KS) is a multicentric tumor caused by Kaposi sarcoma herpesvirus (KSHV) that leads to morbidity and mortality among people with HIV worldwide. KS commonly involves the skin but can occur in the...

    Authors: Ramya Ramaswami, Takanobu Tagawa, Guruswamy Mahesh, Anna Serquina, Vishal Koparde, Kathryn Lurain, Sarah Dremel, Xiaofan Li, Ameera Mungale, Alex Beran, Zoe Weaver Ohler, Laura Bassel, Andrew Warner, Ralph Mangusan, Anaida Widell, Irene Ekwede…
    Citation: Journal of Translational Medicine 2023 21:653
  38. Parkinson's disease (PD), characterized by the progressive loss of dopaminergic neurons in the substantia nigra and striatum of brain, seriously threatens human health, and is still lack of effective treatment...

    Authors: Yan Geng, Xinyi Long, Yuting Zhang, Yupeng Wang, Guoxing You, Wenjie Guo, Gaoming Zhuang, Yuanyuan Zhang, Xiao Cheng, Zhengqiang Yuan and Jie Zan
    Citation: Journal of Translational Medicine 2023 21:652
  39. Pathological neovascularization plays a pivotal role in the onset and progression of tumors and neovascular eye diseases. Despite notable advancements in the development of anti-angiogenic medications that tar...

    Authors: Jun-Song Ren, Wen Bai, Jing-Juan Ding, Hui-Min Ge, Su-Yu Wang, Xi Chen and Qin Jiang
    Citation: Journal of Translational Medicine 2023 21:651
  40. Alzheimer's disease (AD), Parkinson's disease (PD), and multiple sclerosis (MS) are three nervous system diseases that partially overlap clinically and genetically. However, bulk RNA-sequencing did not accurat...

    Authors: Li-Yuan Fan, Jing Yang, Ruo-Yu Liu, Ying Kong, Guang-Yu Guo and Yu-Ming Xu
    Citation: Journal of Translational Medicine 2023 21:649
  41. Memory B cells and microRNAs (miRNAs) play important roles in the progression of gastric adenocarcinoma (GAC), also known as stomach adenocarcinoma (STAD). However, few studies have investigated the use of mem...

    Authors: Ruquan Liu, Biaojie Huang, Yongzhao Shao, Yongming Cai, Xi Liu and Zhonglu Ren
    Citation: Journal of Translational Medicine 2023 21:648
  42. Cervical cancer is one of the most common gynecological cancers threatening women’s health worldwide. Double-stranded RNA-binding proteins (dsRBPs) regulate innate immunity and are therefore believed to be inv...

    Authors: Jin Li, Chong Wan, Xiaoqi Li, Chenlian Quan, Xiaoqiu Li and Xiaohua Wu
    Citation: Journal of Translational Medicine 2023 21:647
  43. The interest in targeted cancer therapies has been growing rapidly. While numerous cancer biomarkers and targeted treatment strategies have been developed and employed, there are still significant limitations ...

    Authors: Feihong Ren, Qiubai Jin, Tongtong Liu, Xuelei Ren and Yongli Zhan
    Citation: Journal of Translational Medicine 2023 21:646
  44. Inflammation in cardiac adipose tissue (AT) is associated with atherosclerosis. We investigated whether the epicardial-, pericardial and pre-sternal subcutaneous AT (EAT, PAT and SAT) expression of Sirtuin1 (S...

    Authors: Trine Baur Opstad, Bianca Papotti, Sissel Åkra, Charlotte Holst Hansen, Bjørn Braathen, Theis Tønnessen, Svein Solheim and Ingebjørg Seljeflot
    Citation: Journal of Translational Medicine 2023 21:644
  45. Despite immunotherapies having revolutionized the treatment of advanced cutaneous melanoma, effective and durable responses were only reported in a few patients. A better understanding of the interaction of me...

    Authors: Helene Schäfer, Karthikeyan Subbarayan, Chiara Massa, Christoforos Vaxevanis, Anja Mueller and Barbara Seliger
    Citation: Journal of Translational Medicine 2023 21:643
  46. Poor medication adherence contributes to increased morbidity and mortality in patients with epilepsy and may be under-addressed in clinical practice. Ethical concerns make it impossible to study the impact of ...

    Authors: Michelle Guignet, Amanda Campbell, Jonathan Vuong, Dale Whittington and H. Steve White
    Citation: Journal of Translational Medicine 2023 21:642

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