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  1. Ipilimumab and Nivolumab, targeting the molecules CTLA-4, PD-1, respectively,have shown efficacy against several types of cancer. Despite these results, only a small percentage of patients maintains a long-las...

    Authors: Paolo Marchetti, Andrea Botticelli, Antonio Paolo Ascierto, Giuseppe Curigliano and Diana Giannarelli

    Citation: Journal of Translational Medicine 2020 18:446

    Content type: Research

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  2. Thymocyte-expressed, positive selection-associated 1 (Tespa1) is a critical signaling molecule in thymocyte development. This study aimed to investigate the regulatory effect of Tespa1 on mast cells in the pat...

    Authors: Ruhui Yang, Guangli Wang, Lingyun Li, Hanjiang He, Mingzhu Zheng, Linrong Lu and Songquan Wu

    Citation: Journal of Translational Medicine 2020 18:444

    Content type: Research

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  3. The tumor microenvironment (TME) is a critical player in tumor progression, metastasis and therapy outcomes. Tumor-associated macrophages (TAMs) are a well-recognized core element of the TME and generally char...

    Authors: Ilseon Hwang, Jeong Won Kim, Kris Ylaya, Eun Joo Chung, Haruhisa Kitano, Candice Perry, Jun Hanaoka, Junya Fukuoka, Joon-Yong Chung and Stephen M. Hewitt

    Citation: Journal of Translational Medicine 2020 18:443

    Content type: Research

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  4. Breast cancer is a highly heterogeneous disease, this poses challenges for classification and management. Long non-coding RNAs play acrucial role in the breast cancersdevelopment and progression, especially in...

    Authors: Wei Ma, Fangkun Zhao, Xinmiao Yu, Shu Guan, Huandan Suo, Zuo Tao, Yue Qiu, Yunfei Wu, Yu Cao and Feng Jin

    Citation: Journal of Translational Medicine 2020 18:442

    Content type: Research

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  5. The novel coronavirus disease (COVID-19) is posing a serious challenge to the health-care systems worldwide, with an enormous impact on health conditions and loss of lives. Notably, obesity and its related com...

    Authors: Antonio Paoli, Stefania Gorini and Massimiliano Caprio

    Citation: Journal of Translational Medicine 2020 18:441

    Content type: Review

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  6. Platelet derived growth factor receptor alpha (PDGFRα) has been considered as a relevant factor in tumor proliferation, angiogenesis and metastatic dissemination. It was a target of tyrosine kinase (TK) inhibi...

    Authors: Nadia Ben Jemii, Haifa Tounsi-Kettiti, Hamza Yaiche, Najla Mezghanni, Amira Jaballah Gabteni, Emna Fehri, Chayma Ben Fayala, Sonia Abdelhak and Samir Boubaker

    Citation: Journal of Translational Medicine 2020 18:440

    Content type: Research

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  7. Poly(ADP-ribose) polymerase inhibitors (PARPis) specifically target homologous recombination deficiency (HRD) cells and display good therapeutic effect in women with advanced-stage BRCA1/2-mutated breast and e...

    Authors: Razan Sheta, Magdalena Bachvarova, Marie Plante, Marie-Claude Renaud, Alexandra Sebastianelli, Jean Gregoire, Jamilet Miranda Navarro, Ricardo Bringas Perez, Jean-Yves Masson and Dimcho Bachvarov

    Citation: Journal of Translational Medicine 2020 18:439

    Content type: Research

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  8. Immunity reaction plays an essential role in periodontitis progress and we aim to investigate the underlying regulatory network of immune reactions in periodontitis.

    Authors: Xiaoqi Zhang, Qingxuan Wang, Xinyu Yan, Yue Shan, Lu Xing, Minqi Li, Hu Long and Wenli Lai

    Citation: Journal of Translational Medicine 2020 18:438

    Content type: Research

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  9. Vectors derived from adeno-associated viruses (AAVs) are widely used for gene transfer both in vitro and in vivo and have gained increasing interest as shuttle systems to deliver therapeutic genes to the heart...

    Authors: Zihou Liu, Kristin Klose, Sebastian Neuber, Meng Jiang, Manfred Gossen and Christof Stamm

    Citation: Journal of Translational Medicine 2020 18:437

    Content type: Methodology

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  10. Squamous cell carcinoma (SCC) is a main pathological type of non-small cell lung cancer. It is common among elderly patients with poor prognosis. We aimed to establish an accurate nomogram to predict survival ...

    Authors: Siying Chen, Chunxia Gao, Qian Du, Lina Tang, Haisheng You and Yalin Dong

    Citation: Journal of Translational Medicine 2020 18:436

    Content type: Research

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  11. Metastasized clear cell renal cell carcinoma (ccRCC) is associated with a poor prognosis. Almost one-third of patients with non-metastatic tumors at diagnosis will later progress with metastatic disease. These...

    Authors: Emma Andersson-Evelönn, Linda Vidman, David Källberg, Mattias Landfors, Xijia Liu, Börje Ljungberg, Magnus Hultdin, Patrik Rydén and Sofie Degerman

    Citation: Journal of Translational Medicine 2020 18:435

    Content type: Research

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  12. Drug repositioning, the strategy of unveiling novel targets of existing drugs could reduce costs and accelerate the pace of drug development. To elucidate the novel molecular mechanism of known drugs, consider...

    Authors: Yihan Zhao, Kai Zheng, Baoyi Guan, Mengmeng Guo, Lei Song, Jie Gao, Hua Qu, Yuhui Wang, Dazhuo Shi and Ying Zhang

    Citation: Journal of Translational Medicine 2020 18:434

    Content type: Research

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  13. Obesity is a chronic low-grade inflammatory disease that is generally characterized by enhanced inflammation in obese adipose tissue (AT). Here, we investigated alterations in gene expression between lean and ...

    Authors: Sang-Hyeop Lee, Nak-Hyeon Choi, In-Uk Koh, Bong-Jo Kim, Song Lee, Song-Cheol Kim and Sun Shim Choi

    Citation: Journal of Translational Medicine 2020 18:433

    Content type: Research

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  14. Extracellular vesicles are heterogeneous populations of naturally occurring secreted small vesicles. EVs function as signaling platforms to facilitate intracellular communication, which indicates the physiolog...

    Authors: Kaiyuan Xu, Qin Liu, Kaihui Wu, Liu Liu, Maomao Zhao, Hui Yang, Xiang Wang and Wenmei Wang

    Citation: Journal of Translational Medicine 2020 18:432

    Content type: Review

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  15. Clinical whole exome sequencing was introduced in an Australian centre in 2017, as an alternative to Sanger sequencing. We aimed to identify predictors of cancer physicians’ somatic mutation test ordering beha...

    Authors: Anastassia Demeshko, David J. Pennisi, Sushil Narayan, Stacy W. Gray, Matthew A. Brown and Aideen M. McInerney-Leo

    Citation: Journal of Translational Medicine 2020 18:431

    Content type: Research

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  16. Immune checkpoint inhibition (ICI) improves survival outcomes for patients with several types of cancer including metastatic melanoma (MM), but serious immune-related adverse events requiring intervention with...

    Authors: Nicholas Gulati, Douglas Donnelly, Yingzhi Qian, Una Moran, Paul Johannet, Judy Zhong and Iman Osman

    Citation: Journal of Translational Medicine 2020 18:430

    Content type: Research

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  17. Neutrophil extracellular traps (NETs) from patients with systemic lupus erythematosus (SLE) are characterized by lower ubiquitylation and myeloperoxidase (MPO) as a substrate. The structural and functional eff...

    Authors: Daniel Alberto Carrillo-Vázquez, Eduardo Jardón-Valadez, Jiram Torres-Ruiz, Guillermo Juárez-Vega, José Luis Maravillas-Montero, David Eduardo Meza-Sánchez, María Lilia Domínguez-López, Jorge Carlos Alcocer Varela and Diana Gómez-Martín

    Citation: Journal of Translational Medicine 2020 18:429

    Content type: Research

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  18. Glioblastoma multiforme (GBM) is the most common malignant brain cancer that invades normal brain tissue and impedes surgical eradication, resulting in early local recurrence and high mortality. In addition, m...

    Authors: Craig A. Land, Phillip R. Musich, Dalia Haydar, Giedre Krenciute and Qian Xie

    Citation: Journal of Translational Medicine 2020 18:428

    Content type: Review

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  19. Foxp3+ regulatory T cells (Tregs) play essential roles in immune homeostasis and repair of damaged lung tissue. We hypothesized that patients whose lung injury resolves quickly, as measured by time to liberation ...

    Authors: Dustin L. Norton, Agathe Ceppe, Miriya K. Tune, Matthew McCravy, Thomas Devlin, M. Bradley Drummond, Shannon S. Carson, Benjamin G. Vincent, Robert S. Hagan, Hong Dang, Claire M. Doerschuk and Jason R. Mock

    Citation: Journal of Translational Medicine 2020 18:427

    Content type: Research

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  20. Iodine is an essential trace element for the production of thyroid hormones, and plays a key role during the gestational period for optimal foetal growth and (neuro-)development. To this day, iodine deficiency...

    Authors: Kristof Y. Neven, Bianca Cox, Karen Vrijens, Michelle Plusquin, Harry A. Roels, Ann Ruttens and Tim S. Nawrot

    Citation: Journal of Translational Medicine 2020 18:426

    Content type: Research

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  21. Diffuse intrinsic pontine glioma (DIPG) is the most common brainstem cancer in childhood. This rapidly progressing brainstem glioma holds a very dismal prognosis with median survival of less than 1 year. Despi...

    Authors: Lincy Thomas, Nataliya Smith, Debra Saunders, Michelle Zalles, Rafal Gulej, Megan Lerner, Kar-Ming Fung, Angel M. Carcaboso and Rheal A. Towner

    Citation: Journal of Translational Medicine 2020 18:424

    Content type: Research

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  22. Approximately 2.5 million people in the U.S. suffer from myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). This disease negatively impacts patients’ ability to function, often resulting in difficult...

    Authors: Turner Palombo, Andrea Campos, Suzanne D. Vernon and Shad Roundy

    Citation: Journal of Translational Medicine 2020 18:423

    Content type: Research

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  23. In the present study the blood expression level of inflammatory response and autoimmunity associated long non-coding RNAs (lncRNAs) were compared in patients with different chronic respiratory diseases and inv...

    Authors: Zsófia Gál, András Gézsi, Ágnes F. Semsei, Adrienne Nagy, Monika Sultész, Zsuzsanna Csoma, Lilla Tamási, Gabriella Gálffy and Csaba Szalai

    Citation: Journal of Translational Medicine 2020 18:422

    Content type: Research

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  24. Heavy tobacco smoking, a hallmark feature of lung cancer, is drastically predominant in Middle Eastern populations. The precise links between nicotine dependence and the functional contribution of the oral mic...

    Authors: Mohammad Tahseen Al Bataineh, Nihar Ranjan Dash, Mohammed Elkhazendar, Dua’a Mohammad Hasan Alnusairat, Islam Mohammad Ismail Darwish, Mohamed Saleh Al-Hajjaj and Qutayba Hamid

    Citation: Journal of Translational Medicine 2020 18:421

    Content type: Research

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  25. Most often, the patients with pancreatic diseases are presented with a mass in pancreatic head region and existing methods of diagnosis fail to confirm whether the head mass is malignant or benign. As subseque...

    Authors: Bishnupriya Chhatriya, Moumita Mukherjee, Sukanta Ray, Barsha Saha, Somdatta Lahiri, Sandip Halder, Indranil Ghosh, Sujan Khamrui, Kshaunish Das, Samsiddhi Bhattacharjee, Saroj Kant Mohapatra and Srikanta Goswami

    Citation: Journal of Translational Medicine 2020 18:420

    Content type: Research

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  26. Obesity is associated with impaired health and lower work ability. Increased physical activity is a cornerstone in the treatment of obesity and related risk factors. Recently, high-intensity interval training ...

    Authors: Dejan Reljic, Fabienne Frenk, Hans J. Herrmann, Markus F. Neurath and Yurdagül Zopf

    Citation: Journal of Translational Medicine 2020 18:419

    Content type: Research

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  27. Cancer stem cells (CSCs) play an important role in drug resistance, recurrence, and metastasis of tumors. Considering the heterogeneity of tumors, this study aimed to explore the key genes regulating stem cell...

    Authors: Rui Guo, Aining Chu and Yuehua Gong

    Citation: Journal of Translational Medicine 2020 18:418

    Content type: Research

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  28. The restoration of host hepatitis B virus (HBV)-specific antiviral immunity is an effective strategy for hepatitis B recovery. Follicular dendritic cells (FDCs) play a crucial role in immune regulation. The go...

    Authors: Xiaoyi Li, Qifan Zhang, Wanyue Zhang, Guofu Ye, Yanchen Ma, Chunhua Wen, Shuqin Gu, Libo Tang and Yongyin Li

    Citation: Journal of Translational Medicine 2020 18:417

    Content type: Research

    Published on:

  29. Accumulating evidence has demonstrated that immune-related lncRNAs (IRLs) are commonly aberrantly expressed in breast cancer (BC). Thus, we aimed to establish an IRL-based tool to improve prognosis prediction ...

    Authors: Jianguo Lai, Bo Chen, Guochun Zhang, Xuerui Li, Hsiaopei Mok and Ning Liao

    Citation: Journal of Translational Medicine 2020 18:416

    Content type: Research

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  30. On December 12, 2019 a new coronavirus (SARS-CoV-2) emerged in Wuhan, China, triggering a pandemic of severe acute respiratory syndrome in humans (COVID-19). Today, the scientific community is investing all th...

    Authors: Laura Di Renzo, Paola Gualtieri, Francesca Pivari, Laura Soldati, Alda Attinà, Claudia Leggeri, Giulia Cinelli, Maria Grazia Tarsitano, Giovanna Caparello, Elena Carrano, Giuseppe Merra, Alberto Maria Pujia, Roberta Danieli and Antonino De Lorenzo

    Citation: Journal of Translational Medicine 2020 18:415

    Content type: Review

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  31. Glycemic variability (GV) represents the amplitude of oscillations in glucose levels over time and is associated with higher mortality in critically ill patients. Our aim is to evaluate the impact of GV on acu...

    Authors: Blanca Fuentes, Silvia Pastor-Yborra, Raquel Gutiérrez-Zúñiga, Noemí González-Pérez de Villar, Elena de Celis, Jorge Rodríguez-Pardo, Mari Carmen Gómez-de Frutos, Fernando Laso-García, María Gutiérrez-Fernández, MÁngeles Ortega-Casarrubios, Alfonso Soto, María López-Fernández, María Santamaría, Noemí Díez-González, Mar M. Freijo, Beatriz Zandio…

    Citation: Journal of Translational Medicine 2020 18:414

    Content type: Protocol

    Published on:

  32. Cancer Associated Macrophage-Like cells (CAMLs) are polynucleated circulating stromal cells found in the bloodstream of numerous solid-tumor malignancies. Variations within CAML size have been associated with ...

    Authors: Daniel J. Gironda, Daniel L. Adams, Jianzhong He, Ting Xu, Hui Gao, Yawei Qiao, Ritsuko Komaki, James M. Reuben, Zhongxing Liao, Mariela Blum-Murphy, Wayne L. Hofstetter, Cha-Mei Tang and Steven H. Lin

    Citation: Journal of Translational Medicine 2020 18:413

    Content type: Research

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  33. The SARS-CoV-2 RNA was detected positive again after discharged from hospital in some COVID-19 patients, with or without clinical symptoms such as fever or dry cough.

    Authors: Yongqing Tong, Anyu Bao, Hongbing Chen, Jingtao Huang, Zhihua Lv, Lina Feng, Yun Cheng, Youna Wang, Li Bai, Wenlong Rao, Hongyun Zheng, Zegang Wu, Bin Qiao, Zhijun Zhao, Huiming Wang and Yan Li

    Citation: Journal of Translational Medicine 2020 18:411

    Content type: Research

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  34. Hypertension and high triglyceride are two of the most important risk factors for hyperuricemia. Epidemiological records show that hypertension and dyslipidemia often coexist and may significantly increase the...

    Authors: Yuan Zhang, Miaomiao Zhang, Xiawen Yu, Fengjiang Wei, Chen Chen, Kai Zhang, Shuzhi Feng, Yaogang Wang and Wei-Dong Li

    Citation: Journal of Translational Medicine 2020 18:409

    Content type: Research

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  35. COronaVIrus Disease 19 (COVID-19) is caused by the infection of the Severe Acute Respiratory Syndrome CoronaVirus 2 (SARS-CoV-2). Although the main clinical manifestations of COVID-19 are respiratory, many pat...

    Authors: S. Greco, A. Madè, C. Gaetano, Y. Devaux, C. Emanueli and F. Martelli

    Citation: Journal of Translational Medicine 2020 18:408

    Content type: Review

    Published on:

  36. Interleukin-6 (IL-6) was proposed to be associated with the severity of coronavirus disease 2019 (COVID-19). The present study aimed to explore the kinetics of IL-6 levels, validate this association in COVID-1...

    Authors: Jing Zhang, Yiqun Hao, Wuling Ou, Fei Ming, Gai Liang, Yu Qian, Qian Cai, Shuang Dong, Sheng Hu, Weida Wang and Shaozhong Wei

    Citation: Journal of Translational Medicine 2020 18:406

    Content type: Research

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  37. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Sean Holden, Rebekah Maksoud, Natalie Eaton-Fitch, Hélène Cabanas, Donald Staines and Sonya Marshall-Gradisnik

    Citation: Journal of Translational Medicine 2020 18:407

    Content type: Correction

    Published on:

    The original article was published in Journal of Translational Medicine 2020 18:290

  38. Tocilizumab blocks pro-inflammatory activity of interleukin-6 (IL-6), involved in pathogenesis of pneumonia the most frequent cause of death in COVID-19 patients.

    Authors: Francesco Perrone, Maria Carmela Piccirillo, Paolo Antonio Ascierto, Carlo Salvarani, Roberto Parrella, Anna Maria Marata, Patrizia Popoli, Laurenzia Ferraris, Massimiliano M. Marrocco-Trischitta, Diego Ripamonti, Francesca Binda, Paolo Bonfanti, Nicola Squillace, Francesco Castelli, Maria Lorenza Muiesan, Miriam Lichtner…

    Citation: Journal of Translational Medicine 2020 18:405

    Content type: Research

    Published on:

  39. Numerous tissue-derived factors have been postulated to be involved in tissue migration of circulating monocytes. The aim of this study was to evaluate whether a defined hypoxic gradient can induce directed mi...

    Authors: Lars Hummitzsch, Rouven Berndt, Matthias Kott, Rene Rusch, Fred Faendrich, Matthias Gruenewald, Markus Steinfath, Martin Albrecht and Karina Zitta

    Citation: Journal of Translational Medicine 2020 18:404

    Content type: Research

    Published on:

  40. In a previous study, we reported that selective dorsal root ganglion stimulation (DRGSTIM) at DRG level L4 promoted a favorable outcome for complex regional pain syndrome (CRPS) patients along with DRGSTIM-relate...

    Authors: Thomas Kinfe, Nico von Willebrand, Andreas Stadlbauer, Michael Buchfelder, Thomas L. Yearwood, Sajjad Muhammad, Shafqat R. Chaudhry, Sascha Gravius, Thomas Randau, Klemens Winder, Christian Maihöfner, Nadine Gravius and Walter Magerl

    Citation: Journal of Translational Medicine 2020 18:403

    Content type: Research

    Published on:

  41. Cancer vaccines provide a complex source of neoantigens. Still, increasing evidence reveals that the neoantigen quality rather than the quantity is predictive for treatment outcome.

    Authors: Inken Salewski, Yvonne Saara Gladbach, Steffen Kuntoff, Nina Irmscher, Olga Hahn, Christian Junghanss and Claudia Maletzki

    Citation: Journal of Translational Medicine 2020 18:402

    Content type: Research

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  42. Marine lipids contain omega-3 fatty acids that can be metabolized into anti-inflammatory and pro-resolving mediators—namely 17-HDHA and 18-HEPE—which can serve as modulators of the pain experience. The purpose...

    Authors: Nini Callan, Doug Hanes and Ryan Bradley

    Citation: Journal of Translational Medicine 2020 18:401

    Content type: Research

    Published on:

  43. Contrast-induced nephropathy (CIN) or contrast-induced acute kidney injury (CI-AKI) is an iatrogenic acute kidney injury observed after intravascular administration of contrast media for intravascular diagnost...

    Authors: Prit Kusirisin, Siriporn C. Chattipakorn and Nipon Chattipakorn

    Citation: Journal of Translational Medicine 2020 18:400

    Content type: Review

    Published on:

  44. Osteonecrosis (ON) is an acquired debilitating skeletal disorder, which is caused by a multitude of traumatic and non-traumatic etiological factors. Vascular damage, mechanical stress and increased intraosseou...

    Authors: S. Elgaz, H. Bonig and P. Bader

    Citation: Journal of Translational Medicine 2020 18:399

    Content type: Review

    Published on:

  45. Bronchopulmonary dysplasia (BPD) is a severe condition in premature infants that compromises lung function and necessitates oxygen support. Despite major improvements in perinatal care minimizing the devastati...

    Authors: Liem Thanh Nguyen, Thai T. H. Trieu, Hue T. H. Bui, Van T. Hoang, Anh T. T. Nguyen, Nhung T. H. Trinh, Kien T. Nguyen and Duc M. Hoang

    Citation: Journal of Translational Medicine 2020 18:398

    Content type: Research

    Published on:

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