Skip to main content

Articles

Page 1 of 96

  1. The gastrointestinal microbiome is an important component of the human body and is closely related to human health and disease. This study describes the hotspots of the human gastrointestinal microbiome resear...

    Authors: Xingzhu Yuan, Chengting Chang, Xinrong Chen and Ka Li

    Citation: Journal of Translational Medicine 2021 19:327

    Content type: Review

    Published on:

  2. A novel and improved methodology is still required for the diagnosis of diabetic kidney disease (DKD). The aim of the present study was to identify novel biomarkers using extracellular vesicle (EV)-derived mRN...

    Authors: Yiying Tao, Xing Wei, Yue Yue, Jiaxin Wang, Jianzhong Li, Lei Shen, Guoyuan Lu, Yang He, Shidi Zhao, Fan Zhao, Zhen Weng, Xiahong Shen and Ling Zhou

    Citation: Journal of Translational Medicine 2021 19:326

    Content type: Research

    Published on:

  3. Chronotype is defined as a trait determining the subject circadian preference in behavioral and biological rhythms relative to external light–dark cycle. Although individual differences in chronotype have been...

    Authors: Luigi Barrea, Giovanna Muscogiuri, Gabriella Pugliese, Roberta Modica, Daniela Laudisio, Sara Aprano, Antongiulio Faggiano, Annamaria Colao and Silvia Savastano

    Citation: Journal of Translational Medicine 2021 19:324

    Content type: Research

    Published on:

  4. Pancreatic cancer is a fatal malignancy of the digestive system and the 5-year survival rate remains low. Therefore, new molecular therapeutic targets are required to improve treatments, prognosis, and the sur...

    Authors: Juan Zeng, Heying Zhang, Yonggang Tan, Zhe Wang, Yunwei Li and Xianghong Yang

    Citation: Journal of Translational Medicine 2021 19:323

    Content type: Research

    Published on:

  5. Early and accurate identification of septic patients at high risk for ICU mortality can help clinicians make optimal clinical decisions and improve the patients’ outcomes. This study aimed to develop and valid...

    Authors: Jie Weng, Ruonan Hou, Xiaoming Zhou, Zhe Xu, Zhiliang Zhou, Peng Wang, Liang Wang, Chan Chen, Jinyu Wu and Zhiyi Wang

    Citation: Journal of Translational Medicine 2021 19:322

    Content type: Research

    Published on:

  6. Early prediction of acute kidney injury (AKI) after liver transplantation (LT) facilitates timely recognition and intervention. We aimed to build a risk predictor of post-LT AKI via supervised machine learning...

    Authors: Yihan Zhang, Dong Yang, Zifeng Liu, Chaojin Chen, Mian Ge, Xiang Li, Tongsen Luo, Zhengdong Wu, Chenguang Shi, Bohan Wang, Xiaoshuai Huang, Xiaodong Zhang, Shaoli Zhou and Ziqing Hei

    Citation: Journal of Translational Medicine 2021 19:321

    Content type: Research

    Published on:

  7. Type 1 diabetes mellitus (T1DM) is a chronic autoimmune disease caused by severe loss of pancreatic β cells. Immune cells are key mediators of β cell destruction. This study attempted to investigate the role o...

    Authors: Jian Lin, Yuanhua Lu, Bizhou Wang, Ping Jiao and Jie Ma

    Citation: Journal of Translational Medicine 2021 19:319

    Content type: Research

    Published on:

  8. Coronavirus disease 2019 (COVID-19) is very contagious. Cases appear faster than the available Polymerase Chain Reaction test kits in many countries. Recently, lung computerized tomography (CT) has been used a...

    Authors: Daryl L. X. Fung, Qian Liu, Judah Zammit, Carson Kai-Sang Leung and Pingzhao Hu

    Citation: Journal of Translational Medicine 2021 19:318

    Content type: Research

    Published on:

  9. Constipation is a common gastrointestinal dysfunction which has a potential impact on people's immune state and their quality of life. Here we investigated the effects of constipation on experimental autoimmun...

    Authors: Xiuli Lin, Yingying Liu, Lili Ma, Xiaomeng Ma, Liping Shen, Xueying Ma, Zhaoyu Chen, Hao Chen, Donghong Li, Zhumin Su and Xiaohong Chen

    Citation: Journal of Translational Medicine 2021 19:317

    Content type: Research

    Published on:

  10. Progressive multiple sclerosis (PMS) is an uncommon and severe subtype of MS that worsens gradually and leads to irreversible disabilities in young adults. Currently, there are no applicable or reliable biomar...

    Authors: Fei Ye, Tianzhu Wang, Xiaoxin Wu, Jie Liang, Jiaoxing Li and Wenli Sheng

    Citation: Journal of Translational Medicine 2021 19:316

    Content type: Research

    Published on:

  11. Sarcopenia is a loss of muscle mass and strength causing disability, morbidity, and mortality in older adults, which is characterized by alterations of the neuromuscular junctions (NMJs). SNAP-25 is essential ...

    Authors: Simone Agostini, Roberta Mancuso, Andrea Saul Costa, Franca Rosa Guerini, Fabio Trecate, Rossella Miglioli, Elisabetta Menna, Beatrice Arosio and Mario Clerici

    Citation: Journal of Translational Medicine 2021 19:315

    Content type: Research

    Published on:

  12. Circular RNA (circRNA) has been demonstrated to participate in cervical cancer development. In this study, we analyzed the role of hsa_circ_0000520 in cervical cancer.

    Authors: Qingling Zheng, Jin Zhang, Ting Zhang, Yanxiang Liu, Xiuluan Du, Xin Dai and Donghua Gu

    Citation: Journal of Translational Medicine 2021 19:314

    Content type: Research

    Published on:

  13. The exploration of genomic alterations in Chinese colorectal liver metastasis (CRLM) is limited, and corresponding genetic biomarkers for patient’s perioperative management are still lacking. This study aims t...

    Authors: Hong-Wei Wang, Xiao-Luan Yan, Li-Jun Wang, Meng-Huan Zhang, Chun-He Yang, Wei-Liu, Ke-Min Jin, Quan Bao, Juan Li, Kun Wang and Bao-Cai Xing

    Citation: Journal of Translational Medicine 2021 19:313

    Content type: Research

    Published on:

  14. Lung cancer is the leading cause of cancer-associated deaths accounting for 24% of all cancer deaths. As a crucial phase of tumor progression, lung cancer metastasis is linked to over 70% of these mortalities....

    Authors: Lei Yin, Xiaotian Liu, Xuejun Shao, Tao Feng, Jun Xu, Qi Wang and Shenghao Hua

    Citation: Journal of Translational Medicine 2021 19:312

    Content type: Review

    Published on:

  15. Colorectal cancer (CRC) is a common malignant tumour of the digestive tract that is characterized by high patient morbidity and mortality rates. Claudin-7 (Cldn7), a tight junction protein, was recently report...

    Authors: Chang Xu, Yu-han Ding, Kun Wang, Mengdi Hao, Huimin Li and Lei Ding

    Citation: Journal of Translational Medicine 2021 19:311

    Content type: Research

    Published on:

  16. Appropriate structural and material properties are essential for finite-element-modeling (FEM). In knee FEM, structural information could extract through 3D-imaging, but the individual subject’s tissue materia...

    Authors: Sandeep Panwar Jogi, Rafeek Thaha, Sriram Rajan, Vidur Mahajan, Vasantha Kumar Venugopal, Anup Singh and Amit Mehndiratta

    Citation: Journal of Translational Medicine 2021 19:310

    Content type: Research

    Published on:

  17. Understanding long-term patterns (trajectories) of cardiovascular diseases (CVD) risk and identifying different sub-groups with the same underlying risk patterns could help facilitate targeted cardiovascular p...

    Authors: Fatemeh Koohi, Nooshin Ahmadi, Farzad Hadaegh, Siavash Safiee, Fereidoun Azizi and Davood Khalili

    Citation: Journal of Translational Medicine 2021 19:309

    Content type: Research

    Published on:

  18. Complex kinase rearrangement, a mutational process involving one or two chromosomes with clustered rearrangement breakpoints, interferes with the accurate detection of kinase fusions by DNA-based next-generati...

    Authors: Peiyi Xia, Lan Zhang, Pan Li, Enjie Liu, Wencai Li, Jianying Zhang, Hui Li, Xiaoxing Su and Guozhong Jiang

    Citation: Journal of Translational Medicine 2021 19:308

    Content type: Research

    Published on:

  19. Several predictive factors for chronic kidney disease (CKD) following radical nephrectomy (RN) or partial nephrectomy (PN) have been identified. However, early postoperative laboratory values were infrequently...

    Authors: Dongwoo Chae, Na Young Kim, Ki Jun Kim, Kyemyung Park, Chaerim Oh and So Yeon Kim

    Citation: Journal of Translational Medicine 2021 19:307

    Content type: Research

    Published on:

  20. Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a serious multifactorial disorder. The origin remains ambiguous, however reduced natural killer (NK) cell cytotoxicity is a consistent immunologic...

    Authors: Natalie Eaton-Fitch, Hélène Cabanas, Stanley du Preez, Donald Staines and Sonya Marshall-Gradisnik

    Citation: Journal of Translational Medicine 2021 19:306

    Content type: Research

    Published on:

  21. Accumulating evidence suggests tRNA-derived fragments (tRFs) play important roles in cellular homeostasis. Here we aimed to explore aberrant expression of tRFs in CD4+ T cells from patients with systemic lupus er...

    Authors: Guannan Geng, Huijing Wang, Weiwei Xin, Zhe Liu, Jie Chen, Zhang Danting, Fei Han and Shuang Ye

    Citation: Journal of Translational Medicine 2021 19:305

    Content type: Research

    Published on:

  22. Panic disorder (PD) is thought to be related with deficits in emotion regulation, especially in cognitive reappraisal. According to the cognitive model, PD patients’ intrinsic and unconscious misappraisal stra...

    Authors: Hai-Yang Wang, Guo-Qing Xu, Ming-Fei Ni, Cui-Hong Zhang, Xue-Lin Li, Yi Chang, Xiao-Pei Sun and Bing-Wei Zhang

    Citation: Journal of Translational Medicine 2021 19:304

    Content type: Research

    Published on:

  23. First-line therapy for metastatic squamous cell carcinoma of the head and neck (R/M HNSCC) has been revolutionized by the introduction of anti-checkpoint monoclonal antibodies, which have shown a significant i...

    Authors: Andrea Botticelli, Giulia Pomati, Alessio Cirillo, Giulia Mammone, Fabio Ciurluini, Bruna Cerbelli, Paolo Sciattella, Massimo Ralli, Umberto Romeo, Francesca De Felice, Carlo Catalano, Francesco Vullo, Marco Della Monaca, Sasan Amirhassankhani, Silverio Tomao, Valentino Valentini…

    Citation: Journal of Translational Medicine 2021 19:303

    Content type: Research

    Published on:

  24. Recently, mesenchymal stem/stromal cells (MSCs) due to their pro-angiogenic, anti-apoptotic, and immunoregulatory competencies along with fewer ethical issues are presented as a rational strategy for regenerat...

    Authors: Soudeh Moghadasi, Marischa Elveny, Heshu Sulaiman Rahman, Wanich Suksatan, Abduladheem Turki Jalil, Walid Kamal Abdelbasset, Alexei Valerievich Yumashev, Siavash Shariatzadeh, Roza Motavalli, Farahnaz Behzad, Faroogh Marofi, Ali Hassanzadeh, Yashwant Pathak and Mostafa Jarahian

    Citation: Journal of Translational Medicine 2021 19:302

    Content type: Review

    Published on:

  25. Pancreatic ductal adenocarcinoma (PDAC) is a fatal disease with molecular heterogeneity, inducing differences in biological behavior, and therapeutic strategy. NGS profiles of pathogenic alterations in the Chi...

    Authors: Lin Shui, Xiaofen Li, Yang Peng, Jiangfang Tian, Shuangshuang Li, Du He, Ang Li, Bole Tian, Mao Li, Heli Gao, Ning An, Cheng Yi and Dan Cao

    Citation: Journal of Translational Medicine 2021 19:301

    Content type: Research

    Published on:

  26. The coronavirus disease 2019 (COVID-19) pandemic has struck globally and is exerting a devastating toll on humans. The pandemic has led to calls for widespread vitamin D supplementation in public. However, evi...

    Authors: Zhiyong Cui and Yun Tian

    Citation: Journal of Translational Medicine 2021 19:300

    Content type: Research

    Published on:

  27. Diabetic nephropathy (DN) has an increasing global prevalence with excessive health expenditure and burden. Exosomal mRNAs regulate intercellular communications and participate in the pathogenesis of various d...

    Authors: Ehsan Hashemi, Hojat Dehghanbanadaki, Alireza Abbasi Baharanchi, Katayoon Forouzanfar, Ardeshir Kakaei, Seyed Mohammad Mohammadi, Saba Zeidi and Farideh Razi

    Citation: Journal of Translational Medicine 2021 19:299

    Content type: Research

    Published on:

  28. Nonradiographic axial spondyloarthropathies (nr-axSpA) are diagnosed by the absence of radiographic sacroiliitis and the presence of bone marrow edema (BME) on magnetic resonance imaging (MRI). According to th...

    Authors: Chun-Chi Lu, Guo-Shu Huang, Tony Szu-Hsien Lee, En Chao, Hsiang-Cheng Chen, Yong-Si Guo, Shi-Jye Chu, Feng-Cheng Liu, San-Yuan Kao, Tsung-Yun Hou, Chen-Hung Chen, Deh-Ming Chang and Sin-Yi Lyu

    Citation: Journal of Translational Medicine 2021 19:298

    Content type: Research

    Published on:

  29. The glutathione S-transferase P1(GSTP1) is an isoenzyme in the glutathione-S transferases (GSTs) enzyme system, which is the most abundant GSTs expressed in adult lungs. Recent research shows that GSTP1 is clo...

    Authors: Xiao Lei, Lehui Du, Wei Yu, Yao Wang, Na Ma and Baolin Qu

    Citation: Journal of Translational Medicine 2021 19:297

    Content type: Review

    Published on:

  30. Immunotherapy is a revolutionary strategy in cancer therapy, but the resistance of which is one of the important challenges. Detecting the regulation of immune cells and biomarkers concerning immune checkpoint...

    Authors: Jingwen Wang, Feng Li, Yanjun Xu, Xuan Zheng, Chunlong Zhang, Congxue Hu, Yingqi Xu, Wanqi Mi, Xia Li and Yunpeng Zhang

    Citation: Journal of Translational Medicine 2021 19:296

    Content type: Research

    Published on:

  31. Metastasis and invasion are crucial in determining the mortality of cervical carcinoma (CC) patients. The epithelial–mesenchymal transition (EMT) is now a universal explanation for the mechanisms of tumor meta...

    Authors: Haoqi Zhao, Lan Wang, Shufang Wang, Xihua Chen, Min Liang, Xin Zhang, Jiedong Wang and Xiangbo Xu

    Citation: Journal of Translational Medicine 2021 19:295

    Content type: Research

    Published on:

  32. This is the first study to build and evaluate a predictive model for early relapse after R0 resection in hepatocellular carcinoma (HCC) patients with microvascular invasion (MVI).

    Authors: Kai Zhang, Changcheng Tao, Tana Siqin, Jianxiong Wu and Weiqi Rong

    Citation: Journal of Translational Medicine 2021 19:293

    Content type: Research

    Published on:

  33. Subjects with chronic obstructive pulmonary disease (COPD) are prone to accelerated decay of muscle strength and mass with advancing age. This is believed to be driven by disease-inherent systemic pathophysiol...

    Authors: Knut Sindre Mølmen, Daniel Hammarström, Gunnar Slettaløkken Falch, Morten Grundtvig, Lise Koll, Marita Hanestadhaugen, Yusuf Khan, Rafi Ahmad, Bente Malerbakken, Tore Jørgen Rødølen, Roger Lien, Bent R. Rønnestad, Truls Raastad and Stian Ellefsen

    Citation: Journal of Translational Medicine 2021 19:292

    Content type: Research

    Published on:

  34. Heart failure (HF) with preserved ejection fraction (HFpEF) is a leading cause of hospitalizations and mortality when diagnosed at the age of ≥ 65 years. HFpEF represents multifactorial and multisystemic syndr...

    Authors: Ying Lin, Shihui Fu, Yao Yao, Yulong Li, Yali Zhao and Leiming Luo

    Citation: Journal of Translational Medicine 2021 19:291

    Content type: Review

    Published on:

  35. We performed a prospective multicentre diagnostic study to evaluate the combined interferon-γ (IFN-γ) and interleukin-2 (IL-2) release assay for detect active pulmonary tuberculosis (TB) in China.

    Authors: Yaoju Tan, Yunhong Tan, Junlian Li, Pengnan Hu, Ping Guan, Haobin Kuang, Qide Liang, Yanyan Yu, Zhongnan Chen, Quan Wang, Zhenping Yang, DiLiNaZi AiKeReMu, Yu Pang and Jianxiong Liu

    Citation: Journal of Translational Medicine 2021 19:289

    Content type: Research

    Published on:

  36. This study aimed to establish and validate an easy-to-operate novel scoring system based on simple and readily available clinical indices for predicting the progression of chronic kidney disease (CKD).

    Authors: Qian Xu, Yunyun Wang, Yiqun Fang, Shanshan Feng, Cuiyun Chen and Yanxia Jiang

    Citation: Journal of Translational Medicine 2021 19:288

    Content type: Research

    Published on:

  37. Reversible enzymatic methylation of mammalian mRNA is widespread and serves crucial regulatory functions, but little is known to what degree chemical alkylators mediate overlapping modifications and whether ce...

    Authors: Kristian Lied Wollen, Lars Hagen, Cathrine B. Vågbø, Renana Rabe, Tobias S. Iveland, Per Arne Aas, Animesh Sharma, Bjørnar Sporsheim, Hilde O. Erlandsen, Vuk Palibrk, Magnar Bjørås, Davi M. Fonseca, Nima Mosammaparast and Geir Slupphaug

    Citation: Journal of Translational Medicine 2021 19:287

    Content type: Research

    Published on:

  38. Understanding the distinct patterns (trajectories) of variation in blood lipid levels before diagnosing cardiovascular disease (CVD) might carry important implications for improving disease prevention or treat...

    Authors: Fatemeh Koohi, Davood Khalili, Mohammad Ali Mansournia, Farzad Hadaegh and Hamid Soori

    Citation: Journal of Translational Medicine 2021 19:286

    Content type: Research

    Published on:

  39. An accurate prediction for prognosis can help in guiding the therapeutic options and optimizing the trial design for generalized myasthenia gravis (gMG). We aimed to develop and validate a predictive nomogram ...

    Authors: Rui Zhao, Ying Wang, Xiao Huan, Huahua Zhong, Zhirui Zhou, Jianying Xi, Yuwei Da, Lin Lei, Ting Chang, Zhe Ruan, Lijun Luo, Shengnan Li, Huan Yang, Yi Li, Sushan Luo and Chongbo Zhao

    Citation: Journal of Translational Medicine 2021 19:285

    Content type: Research

    Published on:

  40. The association between serum advanced oxidation protein products (AOPP) and mortality risk remains equivocal. We aimed to assess the correlation of serum AOPP levels with the risk of all-cause mortality in he...

    Authors: Chun Zhou, Yuanyuan Zhang, Jianghua Chen, Changlin Mei, Fei Xiong, Wei Shi, Wei Zhou, Xusheng Liu, Shiren Sun, Jianwei Tian, Ziliang Ye, Qimeng Wu, Xianhui Qin, Jianping Jiang and Fan Fan Hou

    Citation: Journal of Translational Medicine 2021 19:284

    Content type: Research

    Published on:

  41. Epithelial-mesenchymal transition (EMT) of mesothelial cells is a key step in the peritoneal fibrosis (PF). Recent evidence indicates that signal transducer and activator of transcription 3 (STAT3) might media...

    Authors: Xiaoxiao Yang, Manchen Bao, Yi Fang, Xiaofang Yu, Jun Ji and Xiaoqiang Ding

    Citation: Journal of Translational Medicine 2021 19:283

    Content type: Research

    Published on:

  42. Colorectal cancer is the third most common diagnosis. Oxaliplatin is used as first-line treatment of colon cancer. However, oxaliplatin resistance greatly reduces its therapeutic effect. SRPK1 involves in pre-...

    Authors: Jing-Qiang Huang, He-Feng Li, Jing Zhu, Jun-Wei Song, Xian-Bin Zhang, Peng Gong, Qiu-Yu Liu, Chun-Hui Zhou, Liang Wang and Li-Yun Gong

    Citation: Journal of Translational Medicine 2021 19:280

    Content type: Research

    Published on:

  43. Metabolic reprograming have been associated with cancer occurrence and progression within the tumor immune microenvironment. However, the prognostic potential of metabolism-related genes in colorectal cancer (...

    Authors: Dagui Lin, Wenhua Fan, Rongxin Zhang, Enen Zhao, Pansong Li, Wenhao Zhou, Jianhong Peng and Liren Li

    Citation: Journal of Translational Medicine 2021 19:279

    Content type: Research

    Published on:

  44. Advances in immune checkpoint therapy and targeted therapy have led to improvement in overall survival for patients with advanced melanoma. Single agent checkpoint PD-1 blockade and combination with BRAF/MEK t...

    Authors: Paolo A. Ascierto, Christian Blank, Reinhard Dummer, Marc S. Ernstoff, Soldano Ferrone, Bernard A. Fox, Thomas F. Gajewski, Claus Garbe, Patrick Hwu, Pawel Kalinski, Michelle Krogsgaard, Roger S. Lo, Jason J. Luke, Bart Neyns, Michael A. Postow, Sergio A. Quezada…

    Citation: Journal of Translational Medicine 2021 19:278

    Content type: Meeting report

    Published on:

  45. Fasting plasma glucose (FPG) and 2-h post challenge plasma glucose (2 h-PCPG), whether as continuous or categorical variables, are associated with incident cardiovascular disease (CVD) and diabetes; however, t...

    Authors: Maryam Kabootari, Samaneh Asgari, Seyedeh Maryam Ghavam, Hengameh Abdi, Fereidoun Azizi and Farzad Hadaegh

    Citation: Journal of Translational Medicine 2021 19:277

    Content type: Research

    Published on:

Annual Journal Metrics