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  1. The mechanism of tumor immune escape and progression in colorectal cancer (CRC) is widely investigated in-vitro to help understand and identify agents that might play a crucial role in response to treatment and i...

    Authors: Nassiba Taib, Maysaloun Merhi, Varghese Inchakalody, Sarra Mestiri, Shereena Hydrose, Karama Makni-Maalej, Afsheen Raza, Fairooz Sahir, Fouad Azizi, Parveen B. Nizamuddin, Queenie Fernandes, Zeenath Safira K. M. Yoosuf, Salam Almoghrabi, Lobna Al-Zaidan, Alaaeldin Shablak, Shahab Uddin…
    Citation: Journal of Translational Medicine 2023 21:235
  2. The intestinal barrier is a complex structure that not only regulates the influx of luminal contents into the systemic circulation but is also involved in immune, microbial, and metabolic homeostasis. Evidence...

    Authors: Elio Haroun, Prashanth Ashok Kumar, Ludovic Saba, Joseph Kassab, Krishna Ghimire, Dibyendu Dutta and Seah H. Lim
    Citation: Journal of Translational Medicine 2023 21:233
  3. The incidence of obesity, a known risk factor for several metabolic and chronic diseases, including numerous malignancies, has risen sharply in the world. Various clinical studies demonstrate that excessive Bo...

    Authors: Ines Barone, Luca Gelsomino, Felice Maria Accattatis, Francesca Giordano, Balazs Gyorffy, Salvatore Panza, Mario Giuliano, Bianca Maria Veneziani, Grazia Arpino, Carmine De Angelis, Pietro De Placido, Daniela Bonofiglio, Sebastiano Andò, Cinzia Giordano and Stefania Catalano
    Citation: Journal of Translational Medicine 2023 21:232
  4. Hypertrophic scar is a fibrotic disease following wound healing and is characterized by excessive extracellular matrix deposition. Autologous microfat grafting proves an effective strategy for the treatment th...

    Authors: Qian Yu, Qiang Dai, Zonglin Huang, Chen Li, Li Yan, Xin Fu, Qian Wang, Yi Zhang, Lei Cai, Zhigang Yang and Ran Xiao
    Citation: Journal of Translational Medicine 2023 21:231
  5. Bloodstream infection (BSI) is a serious hematopoietic stem cell transplantation (HSCT) complication. The intestinal microbiome regulates host metabolism and maintains intestinal homeostasis. Thus, the impact ...

    Authors: Guankun Yin, Yifan Guo, Qi Ding, Shuai Ma, Fengning Chen, Qi Wang, Hongbin Chen and Hui Wang
    Citation: Journal of Translational Medicine 2023 21:230
  6. To examine the hypothesis that obesity complicated by the metabolic syndrome, compared to uncomplicated obesity, has distinct molecular signatures and metabolic pathways.

    Authors: Fayaz Ahmad Mir, Raghvendra Mall, Ehsan Ullah, Ahmad Iskandarani, Farhan Cyprian, Tareq A. Samra, Meis Alkasem, Ibrahem Abdalhakam, Faisal Farooq, Shahrad Taheri and Abdul-Badi Abou-Samra
    Citation: Journal of Translational Medicine 2023 21:229
  7. Diabetic nephropathy (DN) is a main cause of chronic renal failure. Despite decades of extensive study, the molecular mechanisms underlying diabetic tubulointerstitial injury remain unclear. We aim to identify...

    Authors: Jialu Liu, Guangzhong Duan, Wenxia Yang, Shumin Zhang, Fuyou Liu, Youming Peng, Lin Sun, Yu Liu and Li Xiao
    Citation: Journal of Translational Medicine 2023 21:228
  8. Mesenchymal stem cell (MSC) therapy has been shown to have some therapeutic effects in rodent models and patients with IBD; however, its role in colon tumor models is controversial. In this study, the potentia...

    Authors: Weiqian Hu, Weijun Wang, Xin Jiang, Zeyu Wang and Rong Lin
    Citation: Journal of Translational Medicine 2023 21:227
  9. Substantial evidence suggests that immunoproteasome is implicated in the various neurological diseases such as stroke, multiple sclerosis and neurodegenerative diseases. However, whether the immunoproteasome i...

    Authors: Xingyong Chen, Yanguang Mao, Yueting Guo, Dongyun Xiao, Zejing Lin, Yiyi Huang, Ying Chun Liu, Xu Zhang and Yinzhou Wang
    Citation: Journal of Translational Medicine 2023 21:226
  10. Chimeric antigen receptor macrophage (CAR-M) therapy is a novel cancer immunotherapy approach that integrates CAR structure and macrophage functions. CAR-M therapy has shown unique and impressive antitumor eff...

    Authors: Yi Huo, Han Zhang, Longqi Sa, Wenjing Zheng, Yang He, Haohan Lyu, Mengjie Sun, Lingling Zhang, Lequn Shan, Angang Yang and Tao Wang
    Citation: Journal of Translational Medicine 2023 21:225
  11. Both the crystalline and soluble forms of cholesterol increase macrophage secretion of interleukin 1β (IL-1β), aggravating the inflammatory response in atherosclerosis (AS). However, the link between cholester...

    Authors: Huanzhi Zhang, Ni Xia, Tingting Tang, Shaofang Nie, Lingfeng Zha, Min Zhang, Bingjie Lv, Yuzhi Lu, Jiao Jiao, Jingyong Li and Xiang Cheng
    Citation: Journal of Translational Medicine 2023 21:224
  12. The prognostic management of bladder cancer (BLCA) remains a great challenge for clinicians. Recently, bulk RNA-seq sequencing data have been used as a prognostic marker for many cancers but do not accurately ...

    Authors: Zhiyong Tan, Xiaorong Chen, Jieming Zuo, Shi Fu, Haifeng Wang and Jiansong Wang
    Citation: Journal of Translational Medicine 2023 21:223
  13. Despite remarkable progress, the immunotherapies currently used in the clinic, such as immune checkpoint blockade (ICB) therapy, still have limited efficacy against many types of solid tumors. One major barrie...

    Authors: Meir Azulay, Michal Shahar, Eitan Shany, Eti Elbaz, Sveta Lifshits, Marie Törngren, Adam Friedmann, Robert Kramer and Gunnar Hedlund
    Citation: Journal of Translational Medicine 2023 21:222
  14. Neoadjuvant concurrent chemoradiotherapy (nCCRT) is a standard treatment for locally advanced rectal cancer (LARC). The gut microbiome may be reshaped by radiotherapy through its effects on microbial compositi...

    Authors: Yi Sun, Xiang Zhang, Chuandi Jin, Kaile Yue, Dashuang Sheng, Tao Zhang, Xue Dou, Jing Liu, Hongbiao Jing, Lei Zhang and Jinbo Yue
    Citation: Journal of Translational Medicine 2023 21:221
  15. Aberrant epigenetic remodeling events contribute to progression and metastasis of breast cancer (Bca). The specific mechanims that epigenetic factors rely on to mediate tumor aggressiveness remain unclear. We ...

    Authors: Sheng Gao, Wensheng Zhang, Jingjing Ma and Xiaojian Ni
    Citation: Journal of Translational Medicine 2023 21:220
  16. Gastrointestinal stromal tumors (GISTs) are the prevailing sarcomas of the gastrointestinal tract. Tyrosine kinase inhibitors (TKIs) therapy, exemplified by Imatinib mesylate (IM), constitutes the established ...

    Authors: Yu Zhao, Zuyi Weng, Xuan Zhou, Zhi Xu, Bei Cao, Bin Wang and Juan Li
    Citation: Journal of Translational Medicine 2023 21:219
  17. The recurrence of hepatocellular carcinoma (HCC) after radiofrequency ablation (RFA) remains a major clinical problem. Cells that survive the sublethal heat stress that is induced by incomplete RFA are the mai...

    Authors: Chao Peng, Xi Li, Feng Ao, Ting Li, Jingpei Guo, Junfeng Liu, Xiaoting Zhang, Jinyan Gu, Junjie Mao and Bin Zhou
    Citation: Journal of Translational Medicine 2023 21:218
  18. T cell activation and programming from their naïve/resting state, characterized by widespread modifications in chromatin accessibility triggering extensive changes in transcriptional programs, is orchestrated ...

    Authors: Erika Di Zazzo, Monica Rienzo, Amelia Casamassimi, Caterina De Rosa, Nicola Medici, Patrizia Gazzerro, Maurizio Bifulco and Ciro Abbondanza
    Citation: Journal of Translational Medicine 2023 21:217
  19. The impact of metabolically healthy obesity (MHO) on kidney dysfunction remains debatable. Moreover, few studies have focused on the early stages of kidney dysfunction indicated by hyperfiltration and mildly r...

    Authors: Hong Zhang, Rui Chen, Xiaohong Xu, Minxing Yang, Wenrong Xu, Shoukui Xiang, Long Wang, Xiaohong Jiang, Fei Hua and Xiaolin Huang
    Citation: Journal of Translational Medicine 2023 21:216
  20. This study aimed to characterize the genetic profile of patients with glioma and discuss the impact of next-generation sequencing in glioma diagnosis and treatment.

    Authors: Veronica Villani, Beatrice Casini, Antonio Tanzilli, Mario Lecce, Fabrizio Rasile, Stefano Telera, Andrea Pace, Francesca Piludu, Irene Terrenato, Francesca Rollo, Francesca De Nicola, Maurizio Fanciulli, Matteo Pallocca, Gennaro Ciliberto and Mariantonia Carosi
    Citation: Journal of Translational Medicine 2023 21:215
  21. Stratification of DNA mismatch repair (MMR) status in patients with colorectal cancer (CRC) enables individual clinical treatment decision making. The present study aimed to develop and validate a deep learnin...

    Authors: Wuteng Cao, Huabin Hu, Jirui Guo, Qiyuan Qin, Yanbang Lian, Jiao Li, Qianyu Wu, Junhong Chen, Xinhua Wang and Yanhong Deng
    Citation: Journal of Translational Medicine 2023 21:214
  22. CD19-targeted chimeric antigen receptor T-cell (CAR-T) therapy has shown remarkable efficacy in treating relapsed or refractory pediatric B-lineage acute lymphoblastic leukemia (B-ALL). However, poor results a...

    Authors: Wenjie Li, Lixia Ding, Wenhua Shi, Xinyu Wan, Xiaomin Yang, Jing Yang, Tianyi Wang, Lili Song, Xiang Wang, Yani Ma, Chengjuan Luo, Jingyan Tang, Longjun Gu, Jing Chen, Jun Lu, Yanjing Tang…
    Citation: Journal of Translational Medicine 2023 21:213
  23. COVID-19, the current global pandemic caused by SARS-CoV-2 infection, can damage the heart and lead to heart failure (HF) and even cardiac death. The 2',5'-oligoadenylate synthetase (OAS) gene family encode in...

    Authors: Li-Juan Gao, Zhong-Mei He, Yi-Ying Li, Rui-Rui Yang, Min Yan, Xuan Shang and Ji-Min Cao
    Citation: Journal of Translational Medicine 2023 21:212
  24. The human body is colonized by abundant and diverse microorganisms, collectively known as the microbiome. The oral cavity has more than 700 species of bacteria and consists of unique microbiome niches on mucos...

    Authors: Xiaoyan Huang, Xiangyu Huang, Yi Huang, Jiarong Zheng, Ye Lu, Zizhao Mai, Xinyuan Zhao, Li Cui and Shaohong Huang
    Citation: Journal of Translational Medicine 2023 21:211
  25. Pancreatic ductal adenocarcinoma (PDAC) has a complex tumor immune microenvironment (TIME), the clinical value of which remains elusive. This study aimed to delineate the immune landscape of PDAC and determine...

    Authors: Kai Chen, Qi Wang, Xinxin Liu, Xiaodong Tian, Aimei Dong and Yinmo Yang
    Citation: Journal of Translational Medicine 2023 21:210
  26. Previous investigations of transcriptomic signatures of cancer patient survival and post-therapy relapse have focused on tumor tissue. In contrast, here we show that in colorectal cancer (CRC) transcriptomes d...

    Authors: Jinho Kim, Hyunjung Kim, Min-Seok Lee, Heetak Lee, Yeon Jeong Kim, Woo Yong Lee, Seong Hyeon Yun, Hee Cheol Kim, Hye Kyung Hong, Sridhar Hannenhalli, Yong Beom Cho, Donghyun Park and Sun Shim Choi
    Citation: Journal of Translational Medicine 2023 21:209
  27. Head and Neck Squamous Cell Carcinoma is a malignant tumor with high morbidity and mortality. The MMP family plays an important role in tumor invasion and metastasis. However, the mechanistic value of the MMP ...

    Authors: Maohua Liu, Lijuan Huang, Yunling Liu, Sen Yang, Yong Rao, Xiao Chen, Minhai Nie and Xuqian Liu
    Citation: Journal of Translational Medicine 2023 21:208
  28. Papillary thyroid microcarcinoma (PTMC) incidence has significantly increased, and some cases still exhibit invasive traits. The entire molecular landscape of PTMC, which can offer hints for the etiology of ca...

    Authors: Qiang Li, Tienan Feng, Tengteng Zhu, Weituo Zhang, Ying Qian, Huan Zhang, Xiangqian Zheng, Dapeng Li, Xinwei Yun, Jingzhu Zhao, Yangyang Li, Herbert Yu, Ming Gao and Biyun Qian
    Citation: Journal of Translational Medicine 2023 21:206
  29. Cytokine-induced memory-like natural killer (CIML NK) cells have been found to possess potent antitumor responses and induce complete remissions in patients with leukemia. However, the poor infiltration of tra...

    Authors: Yanbing Dong, Ying Hung, Zhe Zhang, Aoxing Chen, Lin Li, Manman Tian, Jie Shen and Jie Shao
    Citation: Journal of Translational Medicine 2023 21:205
  30. Endometrial cancer (EC) is one of the most common gynecological malignancies globally, and the development of innovative, effective drugs against EC remains a key issue. Phytoestrogen kaempferol exhibits anti-...

    Authors: Guan-Yu Ruan, Li-Xiang Ye, Jian-Song Lin, Hong-Yu Lin, Li-Rui Yu, Cheng-Yan Wang, Xiao-Dan Mao, Shui-Hua Zhang and Peng-Ming Sun
    Citation: Journal of Translational Medicine 2023 21:204
  31. The incidence of pediatric inflammatory bowel disease (PIBD) has been steadily increasing globally. Delayed diagnosis of PIBD increases the risk of complications and contributes to growth retardation. To impro...

    Authors: Xixi Chen, Yuanqi Gao, Jinfang Xie, Huiying Hua, Chun Pan, Jiebin Huang, Mengxia Jing, Xuehua Chen, Chundi Xu, Yujing Gao and Pu Li
    Citation: Journal of Translational Medicine 2023 21:203
  32. Tumor cell density is a basic pathological feature of solid tumors. Chemotherapy, radiotherapy, and targeted therapy reduce tumor cell density, whereas unrestricted tumor cell proliferation promotes this featu...

    Authors: Mengchao Yan, Jia Yao, Yan Lin, Jun Yan, Ye Xie, Zongli Fu, Yongqiang Zhou, Jiayun Wei and Xun Li
    Citation: Journal of Translational Medicine 2023 21:202
  33. The prognosis of pancreatic cancer patients remains relatively poor. Although some patients would receive surgical resection, distant metastasis frequently occurs within one year. Epithelial-mesenchymal transi...

    Authors: Yuanyang Wang, Cheng Qin, Bangbo Zhao, Zeru Li, Tianyu Li, Xiaoying Yang, Yutong Zhao and Weibin Wang
    Citation: Journal of Translational Medicine 2023 21:201
  34. Diabetic cardiomyopathy (DCM) has been considered as a major threat to health in individuals with diabetes. GrpE-like 2 (Grpel2), a nucleotide exchange factor, has been shown to regulate mitochondrial import p...

    Authors: Rongjin Yang, Xiaomeng Zhang, Yunyun Zhang, Yingfan Wang, Man Li, Yuancui Meng, Jianbang Wang, Xue Wen, Jun Yu and Pan Chang
    Citation: Journal of Translational Medicine 2023 21:200
  35. Increased circulating uric acid (UA) concentration may disrupt cardiac function in heart failure patients, but the specific mechanism remains unclear. Here, we postulate that hyperuremia induces sterol regulat...

    Authors: Bowen Lou, Haoyu Wu, Hannes Ott, Katrin Bennewitz, Chen Wang, Gernot Poschet, Hui Liu, Zuyi Yuan, Jens Kroll and Jianqing She
    Citation: Journal of Translational Medicine 2023 21:199
  36. Temozolomide (TMZ) is the preferred chemotherapy strategy for glioma therapy. As a second-generation alkylating agent, TMZ provides superior oral bio-availability. However, limited response rate (less than 50%...

    Authors: Xiaoying Hou, Hongzhi Du, Yufei Deng, Haiping Wang, Jinmi Liu, Jialu Qiao, Wei Liu, Xiji Shu, Binlian Sun and Yuchen Liu
    Citation: Journal of Translational Medicine 2023 21:198
  37. Cancer immunotherapies utilizing genetically engineered T cells have emerged as powerful personalized therapeutic agents showing dramatic preclinical and clinical results, particularly in hematological maligna...

    Authors: Piotr Celichowski, Marcello Turi, Sandra Charvátová, Dhwani Radhakrishnan, Neda Feizi, Zuzana Chyra, Michal Šimíček, Tomáš Jelínek, Juli Rodriguez Bago, Roman Hájek and Matouš Hrdinka
    Citation: Journal of Translational Medicine 2023 21:197
  38. Owing to metabolic disequilibrium and immune suppression, intracerebral hemorrhage (ICH) patients are prone to infections; according to a recent global analysis of stroke cases, approximately 10 million new-on...

    Authors: Jie Lin, Ya Xu, Peiwen Guo, Yù-Jié Chen, Jiru Zhou, Min Xia, Binbin Tan, Xin Liu, Hua Feng and Yujie Chen
    Citation: Journal of Translational Medicine 2023 21:196
  39. Gut microbiota modulation has been demonstrated to be effective in protecting patients against detrimental effects of anti-cancer therapies, as well as to improve the efficacy of certain anti-cancer treatments...

    Authors: Rossella Salemi, Silvia Vivarelli, Daria Ricci, Marina Scillato, Maria Santagati, Giuseppe Gattuso, Luca Falzone and Massimo Libra
    Citation: Journal of Translational Medicine 2023 21:195
  40. Prostate cancer is one of the most common cancers in men with notable interpatient heterogeneity. Implications of the immune microenvironment in predicting the biochemical recurrence-free survival (BCRFS) afte...

    Authors: Sujun Han, Taoping Shi, Yuchen Liao, Dong Chen, Feiya Yang, Mingshuai Wang, Jing Ma, Hu Li, Yu Xu, Tengfei Zhu, Wenxi Chen, Guoqiang Wang, Yusheng Han, Chunwei Xu, Wenxian Wang, Shangli Cai…
    Citation: Journal of Translational Medicine 2023 21:194
  41. In the repair of maxillofacial bone defects, autogenous craniofacial bone can often provide superior clinical results over long bone grafts. Most current studies have focused on the osteogenic differences betw...

    Authors: Lanxin Gu, Zhongyuan Wang, Hong Gu, Hua Wang, Luwei Liu and Wei-Bing Zhang
    Citation: Journal of Translational Medicine 2023 21:193
  42. Body mass index (BMI) and lipid parameters are the most commonly used anthropometric parameters and biomarkers for assessing nonalcoholic fatty liver disease (NAFLD) risk. This study aimed to assess and quanti...

    Authors: Song Lu, Qiyang Xie, Maobin Kuang, Chong Hu, Xinghui Li, Huijian Yang, Guotai Sheng, Guobo Xie and Yang Zou
    Citation: Journal of Translational Medicine 2023 21:192
  43. The incidence and mortality of gastric cancer ranks fifth and fourth worldwide among all malignancies, respectively. Accumulating evidences have revealed the close relationship between mitochondrial dysfunctio...

    Authors: Jingjia Chang, Hao Wu, Jin Wu, Ming Liu, Wentao Zhang, Yanfen Hu, Xintong Zhang, Jing Xu, Li Li, Pengfei Yu and Jianjun Zhu
    Citation: Journal of Translational Medicine 2023 21:191
  44. The growing epidemic of the inflammation-related metabolic disease, type 2 diabetes mellitus, presents a challenge to improve our understanding of potential mechanisms or biomarkers to prevent or better contro...

    Authors: Nicole Noren Hooten, Nicolle A. Mode, Edward Kowalik, Victor Omoniyi, Alan B. Zonderman, Ngozi Ezike, Mark J. DiNubile, Susan L. Levinson and Michele K. Evans
    Citation: Journal of Translational Medicine 2023 21:190
  45. The inner membrane mitochondrial protein (IMMT) is a central unit of the mitochondrial contact site and cristae organizing system (MICOS). While researchers continue to demonstrate the physiological function o...

    Authors: Hung-Yu Lin, Hsing-Ju Wu and Pei-Yi Chu
    Citation: Journal of Translational Medicine 2023 21:189
  46. To explore the association between translocase of the inner mitochondrial membrane 13 (Timm13) and liver fibrosis.

    Authors: Xiaomin Liao, Xianxian Ruan, Xianbin Wu, Zhejun Deng, Shanyu Qin and Haixing Jiang
    Citation: Journal of Translational Medicine 2023 21:188
  47. Emerging evidence suggests that DNA methylation can be affected by physical activities and is associated with cardiac fibrosis. This translational research examined the implications of DNA methylation associat...

    Authors: Chih-Chin Hsu, Jong-Shyan Wang, Yu-Chiau Shyu, Tieh-Cheng Fu, Yu-Hsiang Juan, Shin-Sheng Yuan, Chao-Hung Wang, Chi-Hsiao Yeh, Po-Cheng Liao, Hsin-Yi Wu and Pang-Hung Hsu
    Citation: Journal of Translational Medicine 2023 21:187
  48. Breast cancer (BC) is a common malignant tumor in women worldwide. Circular RNA (circRNA) has been proven to play a critical role in BC progression. However, the exact biological functions and underlying mecha...

    Authors: Bin Wang, Hang Chen, Yumei Deng, Hong Chen, Lei Xing, Yuping Guo, Min Wang and Junxia Chen
    Citation: Journal of Translational Medicine 2023 21:186

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