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  1. Epithelial ovarian cancer (EOC) is the most lethal disease among female genital malignant tumors. Peptidylarginine deiminase type II(PADI II) has been shown to enhance a variety of cancers carcinogenesis, incl...

    Authors: Lidong Liu, Zhiwei Zhang, Guoxiang Zhang, Ting Wang, Yingchun Ma and Wei Guo

    Citation: Journal of Translational Medicine 2020 18:357

    Content type: Research

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  2. Mesenchymal stromal cells are a safe and promising option to treat knee osteoarthritis as previously demonstrated in different clinical trials. However, their efficacy, optimal dose and addition of adjuvants m...

    Authors: José María Lamo-Espinosa, Juan F. Blanco, Mikel Sánchez, Victoria Moreno, Froilán Granero-Moltó, Fermín Sánchez-Guijo, Íñigo Crespo-Cullel, Gonzalo Mora, Diego Delgado San Vicente, Orlando Pompei-Fernández, Jesús Dámaso Aquerreta, Jorge María Núñez-Córdoba, María Vitoria Sola, Andrés Valentí-Azcárate, Enrique J. Andreu, María del Consuelo del Cañizo…

    Citation: Journal of Translational Medicine 2020 18:356

    Content type: Research

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  3. Spectrin repeat containing nuclear envelope family member 3 (SYNE3) encodes an essential component of the linker of the cytoskeleton and nucleoskeleton (LINC) complex, namely nesprin-3. In a tumor, invasivenes...

    Authors: Liwei Liao, Longshan Zhang, Mi Yang, Xiaoqing Wang, Weiqiang Huang, Xixi Wu, Hua Pan, Lu Yuan, Wenqi Huang, Yuting Wu and Jian Guan

    Citation: Journal of Translational Medicine 2020 18:355

    Content type: Research

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  4. Severe COVID-19 infection results in a systemic inflammatory response (SIRS). This SIRS response shares similarities to the changes observed during the peri-operative period that are recognised to be associate...

    Authors: Donogh Maguire, Marylynne Woods, Conor Richards, Ross Dolan, Jesse Wilson Veitch, Wei M. J. Sim, Olivia E. H. Kemmett, David C. Milton, Sophie L. W. Randall, Ly D. Bui, Nicola Goldmann, Allan Cameron, Barry Laird, Dinesh Talwar, Ian Godber, Alan Davidson…

    Citation: Journal of Translational Medicine 2020 18:354

    Content type: Research

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  5. The outbreak of Coronavirus disease of 2019 (COVID-19) caused by the Severe Acute Respiratory Syndrome coronavirus 2 (SARS-CoV-2), has posed a serious health threat. The increasing number of COVID-19 cases aro...

    Authors: Manoj Kumar and Souhaila Al Khodor

    Citation: Journal of Translational Medicine 2020 18:353

    Content type: Review

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  6. Understanding how HLA polymorphisms may affect both susceptibility, course and severity of Covid-19 infection could help both at the clinical level to identify individuals at higher risk from the disease and a...

    Authors: Simona Pisanti, Joris Deelen, Anna Maria Gallina, Mariella Caputo, Marianna Citro, Mario Abate, Nicoletta Sacchi, Carmine Vecchione and Rosanna Martinelli

    Citation: Journal of Translational Medicine 2020 18:352

    Content type: Research

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  7. Foetal bovine serum (FBS), is the most commonly used culture medium additive for in vitro cultures, despite its undefined composition, its potential immunogenicity and possible prion/zoonotic transmission. For...

    Authors: M. Guiotto, W. Raffoul, A. M. Hart, M. O. Riehle and P. G. di Summa

    Citation: Journal of Translational Medicine 2020 18:351

    Content type: Review

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  8. Unresectable or metastatic vulvar cancer has relatively poor outcomes despite chemotherapy-sensitized radiation therapy and combination cytotoxic therapy. Despite the virus-associated and immunogenic nature of...

    Authors: Oladapo Yeku, Andrea L. Russo, Hang Lee and David Spriggs

    Citation: Journal of Translational Medicine 2020 18:350

    Content type: Protocol

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  9. Omega-3 fatty acids (Ω-3 PUFAs) may help to improve health status in polycystic ovarian syndrome (PCOS) by reducing numerous metabolic disorders (insulin sensitivity, hyperinsulinemia, lipid profile, obesity a...

    Authors: Fiza Komal, Muhammad Kamran Khan, Muhammad Imran, Muhammad Haseeb Ahmad, Haseeb Anwar, Usman Ali Ashfaq, Nazir Ahmad, Amna Masroor, Rabia Shabir Ahmad, Muhammad Nadeem and Mahr Un Nisa

    Citation: Journal of Translational Medicine 2020 18:349

    Content type: Research

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  10. To introduce the Hemorrhage Intensive Severity and Survivability (HISS) score, based on the fusion of multi-biomarker data; glucose, lactate, pH, potassium, and oxygen tension, to serve as a patient-specific a...

    Authors: Ankita Bhat, Daria Podstawczyk, Brandon K. Walther, John R. Aggas, David Machado-Aranda, Kevin R. Ward and Anthony Guiseppi-Elie

    Citation: Journal of Translational Medicine 2020 18:348

    Content type: Research

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  11. The prediction of potential drug-target interactions (DTIs) not only provides a better comprehension of biological processes but also is critical for identifying new drugs. However, due to the disadvantages of...

    Authors: Bo-Ya Ji, Zhu-Hong You, Han-Jing Jiang, Zhen-Hao Guo and Kai Zheng

    Citation: Journal of Translational Medicine 2020 18:347

    Content type: Research

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  12. The melanoma treatment landscape changed in 2011 with the approval of the first anti-cytotoxic T-lymphocyte-associated protein (CTLA)-4 checkpoint inhibitor and of the first BRAF-targeted monoclonal antibody, ...

    Authors: Paolo A. Ascierto, Igor Puzanov, Sanjiv S. Agarwala, Christian Blank, Richard D. Carvajal, Sandra Demaria, Reinhard Dummer, Marc Ernstoff, Soldano Ferrone, Bernard A. Fox, Thomas F. Gajewski, Claus Garbe, Patrick Hwu, Roger S. Lo, Georgina V. Long, Jason J. Luke…

    Citation: Journal of Translational Medicine 2020 18:346

    Content type: Meeting report

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  13. Coronavirus disease 2019 (COVID-19), which is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), spreads rapidly and has attracted worldwide attention.

    Authors: Shuo Jiang, Qiuyue Li, Chaoqun Li, Shanshan Liu, Xiaomeng He, Tao Wang, Hua Li, Christopher Corpe, Xiaoyan Zhang, Jianqing Xu and Jin Wang

    Citation: Journal of Translational Medicine 2020 18:345

    Content type: Research

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  14. In the current systematic review and meta-analysis, we summarized the studies that evaluated the effects of sugar-sweetened beverages (SSBs) intake on blood pressure among children and adolescents.

    Authors: Mahdieh Abbasalizad Farhangi, Leila Nikniaz and Mahdieh Khodarahmi

    Citation: Journal of Translational Medicine 2020 18:344

    Content type: Review

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  15. Distal cholangiocarcinoma is an aggressive malignancy with a dismal prognosis. Diagnostic and prognostic biomarkers for distal cholangiocarcinoma are lacking. The aim of the present study was to identify diffe...

    Authors: Johannes Byrling, Theresa Kristl, Dingyuan Hu, Indira Pla, Aniel Sanchez, Agata Sasor, Roland Andersson, György Marko-Varga and Bodil Andersson

    Citation: Journal of Translational Medicine 2020 18:343

    Content type: Research

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  16. Hypoxia plays an indispensable role in the development of hepatocellular carcinoma (HCC). However, there are few studies on the application of hypoxia molecules in the prognosis predicting of HCC. We aim to id...

    Authors: Baohui Zhang, Bufu Tang, Jianyao Gao, Jiatong Li, Lingming Kong and Ling Qin

    Citation: Journal of Translational Medicine 2020 18:342

    Content type: Research

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  17. Malignant pleural mesothelioma (MPM) is an aggressive neoplasm of the pleura, mainly related to asbestos exposure. As in other solid tumors, malignant cells exhibit high glucose uptake and glycolytic rates wit...

    Authors: Irene Dell’Anno, Elisa Barone, Luciano Mutti, Doris M. Rassl, Stefan J. Marciniak, Roberto Silvestri, Stefano Landi and Federica Gemignani

    Citation: Journal of Translational Medicine 2020 18:341

    Content type: Research

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  18. Duodenal adenocarcinoma (DA) is a rare yet aggressive malignancy, with increasing incidence in the last decades. Its low frequency has hampered a thorough understanding of the pathogenesis of the disease and o...

    Authors: G. Donisi, G. Capretti, N. Cortese, A. Rigamonti, F. Gavazzi, G. Nappo, A. Pulvirenti, M. Sollai, P. Spaggiari, A. Zerbi and F. Marchesi

    Citation: Journal of Translational Medicine 2020 18:340

    Content type: Research

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  19. The cohesin complex plays a major role in folding the human genome into 3D structural domains. Mutations in members of the cohesin complex are known early drivers of myelodysplastic syndromes (MDS) and acute m...

    Authors: James S. Smith, Katrina M. Lappin, Stephanie G. Craig, Fabio G. Liberante, Clare M. Crean, Simon S. McDade, Alexander Thompson, Ken I. Mills and Kienan I. Savage

    Citation: Journal of Translational Medicine 2020 18:339

    Content type: Research

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  20. Severe acute respiratory syndrome CoV-2 (SARS-CoV-2) caused the first coronavirus disease 2019 (COVID-19) outbreak in China and has become a public health emergency of international concern. SARS-CoV-2 outbrea...

    Authors: Maria Pachetti, Bruna Marini, Fabiola Giudici, Francesca Benedetti, Silvia Angeletti, Massimo Ciccozzi, Claudio Masciovecchio, Rudy Ippodrino and Davide Zella

    Citation: Journal of Translational Medicine 2020 18:338

    Content type: Research

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  21. Immune-related genes (IRGs) have been confirmed to have an important role in tumorigenesis and tumor microenvironment formation. Nevertheless, a systematic analysis of IRGs and their clinical significance in s...

    Authors: Chuan Hu, Bo Chen, Zhangheng Huang, Chuan Liu, Lin Ye, Cailin Wang, Yuexin Tong, Jiaxin Yang and Chengliang Zhao

    Citation: Journal of Translational Medicine 2020 18:337

    Content type: Research

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  22. Since the 1990s, neuroimaging has been utilised to study Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS), a debilitating illness with unknown aetiology. While brain abnormalities in ME/CFS have bee...

    Authors: Zack Y. Shan, Leighton R. Barnden, Richard A. Kwiatek, Sandeep Bhuta, Daniel F. Hermens and Jim Lagopoulos

    Citation: Journal of Translational Medicine 2020 18:335

    Content type: Review

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  23. African American women experience a twofold higher incidence of triple-negative breast cancer (TNBC) and are 40% more likely to die from breast cancer than women of other ethnicities. However, the molecular ba...

    Authors: Xuan Yang, Mohamed Amgad, Lee A. D. Cooper, Yuhong Du, Haian Fu and Andrey A. Ivanov

    Citation: Journal of Translational Medicine 2020 18:334

    Content type: Research

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  24. Recently, it has been reported that miRNA is involved in pterygium, however the exact underlying mechanism in pterygium is unrevealed and require further investigation.

    Authors: Siying He, Yifang Huang, Shiqi Dong, Chen Qiao, Guohua Yang, Shuai Zhang, Chen Wang, Yuting Xu, Fang Zheng and Ming Yan

    Citation: Journal of Translational Medicine 2020 18:332

    Content type: Research

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  25. The study of localized immune-related factors has proven beneficial for a variety of conditions, and one area of interest in the field of orthopaedics is the impact of implants and localized infections on immu...

    Authors: Nicole Prince, Julia A. Penatzer, Matthew J. Dietz and Jonathan W. Boyd

    Citation: Journal of Translational Medicine 2020 18:330

    Content type: Research

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  26. The new Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2), which was first detected in Wuhan (China) in December of 2019 is responsible for the current global pandemic. Phylogenetic analysis reveale...

    Authors: Francesca Benedetti, Greg A. Snyder, Marta Giovanetti, Silvia Angeletti, Robert C. Gallo, Massimo Ciccozzi and Davide Zella

    Citation: Journal of Translational Medicine 2020 18:329

    Content type: Research

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  27. Patients with severe Coronavirus Disease 2019 (COVID-19) will progress rapidly to acute respiratory failure or death. We aimed to develop a quantitative tool for early predicting mortality risk of patients wit...

    Authors: Zhihong Weng, Qiaosen Chen, Sumeng Li, Huadong Li, Qian Zhang, Sihong Lu, Li Wu, Leiqun Xiong, Bobin Mi, Di Liu, Mengji Lu, Dongliang Yang, Hongbo Jiang, Shaoping Zheng and Xin Zheng

    Citation: Journal of Translational Medicine 2020 18:328

    Content type: Research

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  28. Liver cancer is among the most common malignancy worldwide. Hepatocellular carcinoma (HCC), the principal histological subtype of liver cancer, is globally the third most common cause of cancer-related mortali...

    Authors: Xia Qin, Jian Zhang, Yu Lin, Xue-ming Sun, Jia-ning Zhang and Zhi-qiang Cheng

    Citation: Journal of Translational Medicine 2020 18:326

    Content type: Research

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  29. Alzheimer’s Disease (AD) is a chronic neurodegenerative disorder characterized by extracellular plaques, intracellular neurofibrillary tangles and neuronal loss in the central nervous system (CNS). Pathogens a...

    Authors: Andrea Saul Costa, Simone Agostini, Franca Rosa Guerini, Roberta Mancuso, Mario Clerici and Janardan P. Pandey

    Citation: Journal of Translational Medicine 2020 18:325

    Content type: Research

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  30. Colon cancer is a disease with high malignancy and incidence in the world. Tumor immune microenvironment (TIM) and tumor mutational burden (TMB) have been proved to play crucial roles in predicting clinical ou...

    Authors: Xinyi Wang, Jinzhong Duanmu, Xiaorui Fu, Taiyuan Li and Qunguang Jiang

    Citation: Journal of Translational Medicine 2020 18:324

    Content type: Research

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  31. Serum cell-free DNA (cfDNA) holds promise as a non-invasive cancer biomarker. The objective of this study was to evaluate the association of cfDNA concentration with clinicopathologic variables of poor prognos...

    Authors: Gregory M. Gressel, Elaine C. Maggi, Bryan E. Harmon, Kenny Q. Ye, D. Y. S. Kuo, Siobhan M. Dolan and Cristina Montagna

    Citation: Journal of Translational Medicine 2020 18:323

    Content type: Research

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  32. The coronavirus disease 2019 (COVID-19) pandemic has led to a declaration of a Public Health Emergency of International Concern by the World Health Organization. As of May 18, 2020, there have been more than 4...

    Authors: Yi Xu, David J. Baylink, Chien-Shing Chen, Mark E. Reeves, Jeffrey Xiao, Curtis Lacy, Eric Lau and Huynh Cao

    Citation: Journal of Translational Medicine 2020 18:322

    Content type: Review

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  33. The outbreak of coronavirus disease (COVID-19) was caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), through its surface spike glycoprotein (S-protein) recognition on the receptor Angiote...

    Authors: Xingyi Guo, Zhishan Chen, Yumin Xia, Weiqiang Lin and Hongzhi Li

    Citation: Journal of Translational Medicine 2020 18:321

    Content type: Research

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  34. Previous findings have indicated that the tumor, nodes, and metastases (TNM) staging system is not sufficient to accurately predict survival outcomes in patients with non-small lung carcinoma (NSCLC). Thus, th...

    Authors: Rui-Qi Wang, Xiao-Ran Long, Chun-Lei Ge, Mei-Yin Zhang, Long Huang, Ning-Ning Zhou, Yi Hu, Rui-Lei Li, Zhen Li, Dong-Ni Chen, Lan-Jun Zhang, Zhe-Sheng Wen, Shi-Juan Mai and Hui-Yun Wang

    Citation: Journal of Translational Medicine 2020 18:320

    Content type: Research

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  35. In less than 20 years, three deadly coronaviruses, SARS-CoV, MERS-CoV and SARS-CoV-2, have emerged in human population causing hundreds to hundreds of thousands of deaths. Other coronaviruses are causing epizo...

    Authors: Laure Perrin-Cocon, Olivier Diaz, Clémence Jacquemin, Valentine Barthel, Eva Ogire, Christophe Ramière, Patrice André, Vincent Lotteau and Pierre-Olivier Vidalain

    Citation: Journal of Translational Medicine 2020 18:319

    Content type: Review

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  36. COVID 19-related quarantine led to a sudden and radical lifestyle changes, in particular in eating habits. Objectives of the study were to investigate the effect of quarantine on sleep quality (SQ) and body mass ...

    Authors: Luigi Barrea, Gabriella Pugliese, Lydia Framondi, Rossana Di Matteo, Daniela Laudisio, Silvia Savastano, Annamaria Colao and Giovanna Muscogiuri

    Citation: Journal of Translational Medicine 2020 18:318

    Content type: Research

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  37. To evaluate the immunomodulatory effect of Lactobacillus sakei in a mouse model of rheumatoid arthritis (RA) and in human immune cells.

    Authors: Jooyeon Jhun, Hong Ki Min, Jaeyoon Ryu, Seon-Yeong Lee, Jun-Geol Ryu, Jeong Won Choi, Hyun Sik Na, Seung Yoon Lee, Yunju Jung, Sang-Jun Park, Myeong Soo Park, Bin Kwon, Geun Eog Ji, Mi-La Cho and Sung-Hwan Park

    Citation: Journal of Translational Medicine 2020 18:317

    Content type: Research

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  38. Antibody based cancer therapies have achieved convincing success rates combining enhanced tumor specificity and reduced side effects in patients. Trastuzumab that targets the human epidermal growth factor rela...

    Authors: Anja Kathrin Wege, Nicole Kirchhammer, Linda Veronique Kazandjian, Sandra Prassl, Michael Brandt, Gerhard Piendl, Olaf Ortmann, Stephan Fischer and Gero Brockhoff

    Citation: Journal of Translational Medicine 2020 18:316

    Content type: Research

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  39. In the rapidly evolving coronavirus disease 2019 (COVID-19) outbreak, inherent literature has been increasing at an impressive rate. Such a dynamic scenario imposes the necessity to define a new framework for ...

    Authors: Maddalena Barba, Eriseld Krasniqi, Gennaro Ciliberto and Patrizia Vici

    Citation: Journal of Translational Medicine 2020 18:315

    Content type: Commentary

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  40. Lightheadedness, fatigue, weakness, heart palpitations, cognitive dysfunction, muscle pain, and exercise intolerance are some of the symptoms of orthostatic intolerance (OI). There is substantial comorbidity o...

    Authors: Jihyun Lee, Suzanne D. Vernon, Patricia Jeys, Weam Ali, Andrea Campos, Derya Unutmaz, Brayden Yellman and Lucinda Bateman

    Citation: Journal of Translational Medicine 2020 18:314

    Content type: Research

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  41. Lung cancer is one of the most common carcinomas in the world, and lung adenocarcinoma (LUAD) is the most lethal and most common subtype of lung cancer. Cigarette smoking is the most leading risk factor of lun...

    Authors: Jin Wang, Tao Chen, Xiaofan Yu, Nan OUYang, Lirong Tan, Beibei Jia, Jian Tong and Jianxiang Li

    Citation: Journal of Translational Medicine 2020 18:313

    Content type: Research

    Published on:

  42. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Qibin Liao, Jin Wang, Zenglin Pei, Jianqing Xu and Xiaoyan Zhang

    Citation: Journal of Translational Medicine 2020 18:312

    Content type: Correction

    Published on:

    The original article was published in Journal of Translational Medicine 2017 15:41

  43. Endometriosis is a chronic inflammatory hormone-dependent condition associated with pelvic pain and infertility, characterized by the growth of ectopic endometrium outside the uterus. Given its still unknown e...

    Authors: Helena Malvezzi, Eliana Blini Marengo, Sérgio Podgaec and Carla de Azevedo Piccinato

    Citation: Journal of Translational Medicine 2020 18:311

    Content type: Review

    Published on:

  44. HIV-1 Vpr encodes a 14 kDa protein that has been implicated in viral pathogenesis through modulation of several host cell functions. In addition to pro-apoptotic and cytostatic properties, Vpr can redirect cel...

    Authors: Patrick Eldin, Sophie Péron, Anastasia Galashevskaya, Nicolas Denis-Lagache, Michel Cogné, Geir Slupphaug and Laurence Briant

    Citation: Journal of Translational Medicine 2020 18:310

    Content type: Research

    Published on:

  45. The intrathecal (IT) dosing route introduces drugs directly into the CSF to bypass the blood–brain barrier and gain direct access to the CNS. We evaluated the use of convective forces acting on the cerebrospin...

    Authors: Jenna M. Sullivan, Curt Mazur, Daniel A. Wolf, Laura Horky, Nicolas Currier, Bethany Fitzsimmons, Jacob Hesterman, Rachel Pauplis, Scott Haller, Berit Powers, Leighla Tayefeh, Bea DeBrosse-Serra, Jack Hoppin, Holly Kordasiewicz, Eric E. Swayze and Ajay Verma

    Citation: Journal of Translational Medicine 2020 18:309

    Content type: Research

    Published on:

  46. Necrotizing enterocolitis (NEC) is one of the most severe complications in very preterm infants, but there are currently no accepted methods to prevent NEC. Studies have shown that erythropoietin (EPO) has the...

    Authors: Yong Wang, Juan Song, Huiqing Sun, Falin Xu, Kenan Li, Chunxia Nie, Xiaoli Zhang, Xirui Peng, Lei Xia, Ziyun Shen, Xiao Yuan, Shan Zhang, Xue Ding, Yaodong Zhang, Wenqing Kang, Liling Qian…

    Citation: Journal of Translational Medicine 2020 18:308

    Content type: Research

    Published on:

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