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  1. Long non-coding RNA (lncRNA) maternally expressed gene 3 (MEG3) has been implicated in the progression of esophageal cancer (EC). However, the specific mechanism of the involvement of MEG3 in EC development in...

    Authors: Qi-Rong Xu, Jian Tang, Hong-Ying Liao, Ben-Tong Yu, Xiang-Yuan He, Yu-Zhen Zheng and Sheng Liu

    Citation: Journal of Translational Medicine 2021 19:264

    Content type: Research

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  2. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Jie Yao, Zefen Wang, Yong Cheng, Chao Ma, Yahua Zhong, Yilei Xiao, Xu Gao and Zhiqiang Li

    Citation: Journal of Translational Medicine 2021 19:263

    Content type: Correction

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    The original article was published in Journal of Translational Medicine 2021 19:99

  3. Sickle cell disease (SCD) is commonly encountered in Africa and Middle Eastern countries. The causative mutation in the gene encoding the hemoglobin subunit β (HBB) leads to various genotypic variants of the d...

    Authors: Ibrahim Khamees, Fateen Ata, Hassan Choudry, Ashraf T. Soliman, Vincenzo De Sanctis and Mohamed A. Yassin

    Citation: Journal of Translational Medicine 2021 19:262

    Content type: Review

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  4. Activator protein-1 (AP1), a c-Fos–JUN transcription factor complex, mediates many cytobiological processes. c-Fos has been implicated in immunoglobulin (Ig)E activation of mast cells (MCs) via high-affinity I...

    Authors: Hui-Na Wang, Kunmei Ji, Li-Na Zhang, Chu-Chu Xie, Wei-Yong Li, Zhen-Fu Zhao and Jia-Jie Chen

    Citation: Journal of Translational Medicine 2021 19:261

    Content type: Research

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  5. Asthma is a frequently occurring respiratory disease with an increasing incidence around the world. Airway inflammation and remodeling are important contributors to the occurrence of asthma. We conducted this ...

    Authors: Wendi Wei, Weida Chen and Naifeng He

    Citation: Journal of Translational Medicine 2021 19:258

    Content type: Research

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  6. We aimed to develop a radiomic model based on pre-treatment computed tomography (CT) to predict the pathological complete response (pCR) in patients with rectal cancer after neoadjuvant treatment and tried to ...

    Authors: Zhuokai Zhuang, Zongchao Liu, Juan Li, Xiaolin Wang, Peiyi Xie, Fei Xiong, Jiancong Hu, Xiaochun Meng, Meijin Huang, Yanhong Deng, Ping Lan, Huichuan Yu and Yanxin Luo

    Citation: Journal of Translational Medicine 2021 19:256

    Content type: Research

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  7. Recent studies reporting the intricate crosstalk between cellular and molecular mediators and the lymphatic endothelium in the development of inflammatory bowel diseases (IBD) suggest altered inflammatory cell...

    Authors: Dickson Kofi Wiredu Ocansey, Bing Pei, Xinwei Xu, Lu Zhang, Chinasa Valerie Olovo and Fei Mao

    Citation: Journal of Translational Medicine 2021 19:254

    Content type: Review

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  8. Polycystic kidney disease (PKD) is a common renal disorder affecting approximately 1 in 1000 live births. Tuberculosis (TB) is an infectious disease worldwide. This study investigated the risk of TB infection ...

    Authors: Ting-Fang Chiu, Tung-Min Yu, Chih-Wei Chiu, Brian K. Lee, Tsuo-Hung Lan, Chi-Yuan Li, Mei-Chen Lin and Chia-Hung Kao

    Citation: Journal of Translational Medicine 2021 19:253

    Content type: Research

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  9. N6-methyl-adenosine (m6A) is one of the most common internal modifications on RNA molecules present in mammalian cells. Deregulation of m6A modification has been recently implicated in many types of human dise...

    Authors: Chang Liu, Zhe Yang, Rong Li, Yanju Wu, Ming Chi, Shuting Gao, Xun Sun, Xin Meng and Biao Wang

    Citation: Journal of Translational Medicine 2021 19:251

    Content type: Review

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  10. Inflammatory bowel disease (IBD) is a chronic and idiopathic inflammatory disorder of the gastrointestinal tract and comprises ulcerative colitis (UC) and Crohn’s disease (CD). Crohn’s disease can affect any p...

    Authors: Ilkyu Park, Jaeeun Jung, Sugi Lee, Kunhyang Park, Jea-Woon Ryu, Mi-Young Son, Hyun-Soo Cho and Dae-Soo Kim

    Citation: Journal of Translational Medicine 2021 19:250

    Content type: Research

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  11. Programmed cell death ligand-1 (PD-L1) expression is a promising biomarker for identifying treatment related to non-small cell lung cancer (NSCLC). Automated image analysis served as an aided PD-L1 scoring too...

    Authors: Boju Pan, Yuxin Kang, Yan Jin, Lin Yang, Yushuang Zheng, Lei Cui, Jian Sun, Jun Feng, Yuan Li, Lingchuan Guo and Zhiyong Liang

    Citation: Journal of Translational Medicine 2021 19:249

    Content type: Research

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  12. This study aimed to explore the collaborative relationship in translational medical research from the perspective of clinicians in China. The findings are expected to help practitioners optimize and experience...

    Authors: Meina Li, Bin Lian, Xiaoxiong Xu, Pan Zhao, Bihan Tang, Chaoqun Hu, Xiang Liu, Wenya Yu and Lulu Zhang

    Citation: Journal of Translational Medicine 2021 19:247

    Content type: Research

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  13. Since the first complete genome sequencing of SARS-CoV-2 in December 2019, more than 550,000 genomes have been submitted into the GISAID database. Sequencing of the SARS-CoV-2 genome might allow identification...

    Authors: Anna Maria Rachiglio, Luca De Sabato, Cristin Roma, Michele Cennamo, Mariano Fiorenza, Daniela Terracciano, Raffaella Pasquale, Francesca Bergantino, Ernesta Cavalcanti, Gerardo Botti, Gabriele Vaccari, Giuseppe Portella and Nicola Normanno

    Citation: Journal of Translational Medicine 2021 19:246

    Content type: Research

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  14. In the era of precision medicine, digital technologies and artificial intelligence, drug discovery and development face unprecedented opportunities for product and business model innovation, fundamentally chan...

    Authors: Dominik Hartl, Valeria de Luca, Anna Kostikova, Jason Laramie, Scott Kennedy, Enrico Ferrero, Richard Siegel, Martin Fink, Sohail Ahmed, John Millholland, Alexander Schuhmacher, Markus Hinder, Luca Piali and Adrian Roth

    Citation: Journal of Translational Medicine 2021 19:245

    Content type: Review

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  15. Peripheral arterial disease (PAD) is accompanied by myopathy characterized by mitochondrial dysfunction. The aim of this experimental study was to investigate the effect of revascularization procedures on mito...

    Authors: Alexandra Gratl, Dominik Pesta, Leonhard Gruber, Fiona Speichinger, Ben Raude, Safwan Omran, Andreas Greiner and Jan Paul Frese

    Citation: Journal of Translational Medicine 2021 19:244

    Content type: Research

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  16. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Tobias S. Iveland, Lars Hagen, Animesh Sharma, Mirta M. L. Sousa, Antonio Sarno, Kristian Lied Wollen, Nina Beate Liabakk and Geir Slupphaug

    Citation: Journal of Translational Medicine 2021 19:243

    Content type: Correction

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    The original article was published in Journal of Translational Medicine 2020 18:159

  17. To investigate the COVID-19 pandemic related alteration of health promoting behaviour during lockdown among medical students compared to other students.

    Authors: Julius Steffen, Jenny Schlichtiger, Stefan Brunner and Bruno C. Huber

    Citation: Journal of Translational Medicine 2021 19:242

    Content type: Letter to the Editor

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  18. Inflammation and oxidative stress form a vicious circle in atherosclerosis. Oxidative stress can have detrimental effects on T cells. A unique subset of CD4+ T cells, known as regulatory T (Treg) cells, has been ...

    Authors: Anna K. Lundberg, Rosanna W. S. Chung, Louise Zeijlon, Gustav Fernström and Lena Jonasson

    Citation: Journal of Translational Medicine 2021 19:241

    Content type: Research

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  19. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Iman Osman, Paolo Cotzia, Una Moran, Douglas Donnelly, Carolina Arguelles-Grande, Sandra Mendoza and Andre Moreira

    Citation: Journal of Translational Medicine 2021 19:240

    Content type: Correction

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    The original article was published in Journal of Translational Medicine 2020 18:219

  20. Improved understanding of tumor immunology has enabled the development of therapies that harness the immune system and prevent immune escape. Numerous clinical trials and real-world experience has provided evi...

    Authors: Paolo A. Ascierto, Carlo Bifulco, Fortunato Ciardiello, Sandra Demaria, Leisha A. Emens, Robert Ferris, Silvia C. Formenti, Jerome Galon, Samir N. Khleif, Tomas Kirchhoff, Jennifer McQuade, Kunle Odunsi, Akash Patnaik, Chrystal M. Paulos, Janis M. Taube, John Timmerman…

    Citation: Journal of Translational Medicine 2021 19:238

    Content type: Meeting report

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  21. Recently, increased interleukin (IL)-24 expression has been demonstrated in the colon biopsies of adult patients with inflammatory bowel disease (IBD). However, the role of IL-24 in the pathomechanism of IBD i...

    Authors: Anna Ónody, Apor Veres-Székely, Domonkos Pap, Réka Rokonay, Beáta Szebeni, Erna Sziksz, Franz Oswald, Gábor Veres, Áron Cseh, Attila J. Szabó and Ádám Vannay

    Citation: Journal of Translational Medicine 2021 19:237

    Content type: Research

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  22. To investigate the performance of diffusion-weighted (DW) MRI with mono-, bi- and stretched-exponential models in predicting pathologic complete response (pCR) to neoadjuvant chemotherapy (NACT) for breast can...

    Authors: Shiteng Suo, Yan Yin, Xiaochuan Geng, Dandan Zhang, Jia Hua, Fang Cheng, Jie Chen, Zhiguo Zhuang, Mengqiu Cao and Jianrong Xu

    Citation: Journal of Translational Medicine 2021 19:236

    Content type: Research

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  23. The hallmark of non-alcoholic fatty liver disease (NAFLD) is the excessive hepatic lipid accumulation. Currently, no pharmacotherapy exists for NAFLD. However, the glucagon-like peptide-1 receptor agonists hav...

    Authors: Khaoula Errafii, Neyla S. Al-Akl, Olfa Khalifa and Abdelilah Arredouani

    Citation: Journal of Translational Medicine 2021 19:235

    Content type: Research

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  24. Adipose cell-free derivatives have been recently gaining attention as potential therapeutic agents for various human diseases. In this context, mesenchymal stromal/stem cells (MSCs), adipocyte mesenchymal stem...

    Authors: Loubna Mazini, Luc Rochette and Gabriel Malka

    Citation: Journal of Translational Medicine 2021 19:234

    Content type: Commentary

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  25. The transcriptomic signature has not been fully elucidated in PV, as well as mRNA markers for clinical variables (thrombosis, leukemic transformation, survival, etc.). We attempted to reveal and validate cruci...

    Authors: Chao Guo, Ya-yue Gao, Qian-qian Ju, Min Wang, Chun-xia Zhang, Ming Gong and Zhen-ling Li

    Citation: Journal of Translational Medicine 2021 19:233

    Content type: Research

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  26. Malignant pleural mesothelioma (MPM) is a rare and aggressive tumour. For patients with inoperable disease, few treatment options are available after first line chemotherapy. The combination of ipilimumab and ...

    Authors: Vilde Drageset Haakensen, Anna K. Nowak, Espen Basmo Ellingsen, Saima Jamil Farooqi, Maria Moksnes Bjaanæs, Henrik Horndalsveen, Tine Mcculloch, Oscar Grundberg, Susana M. Cedres and Åslaug Helland

    Citation: Journal of Translational Medicine 2021 19:232

    Content type: Protocol

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  27. Intratumour heterogeneous gene expression among cancer and cancer stem cells (CSCs) can cause failure of current targeted therapies because each drug aims to target the function of a single gene. Long mononucl...

    Authors: Narumol Bhummaphan, Piyapat Pin-on, Preeyaporn Plaimee Phiboonchaiyanan, Jirattha Siriluksana, Chatchawit Aporntewan, Pithi Chanvorachote and Apiwat Mutirangura

    Citation: Journal of Translational Medicine 2021 19:231

    Content type: Research

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  28. Infections are a major disease burden worldwide. While they are caused by external pathogens, host genetics also plays a part in susceptibility to infections. Past studies have reported diverse associations be...

    Authors: Ron Nudel, Rosa Lundbye Allesøe, Wesley K. Thompson, Thomas Werge, Simon Rasmussen and Michael E. Benros

    Citation: Journal of Translational Medicine 2021 19:230

    Content type: Research

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  29. There is growing evidence discussing the role of long non-coding RNAs (lncRNAs) in cervical cancer (CC). We performed this study to explore the impact of exosomal lncRNA urothelial cancer-associated 1 (UCA1) i...

    Authors: Zhihui Gao, Qianqing Wang, Mei Ji, Xiangcui Guo, Li Li and Xiaoke Su

    Citation: Journal of Translational Medicine 2021 19:229

    Content type: Research

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  30. The heterogenous cytogenetic and molecular variations were harbored by AML patients, some of which are related with AML pathogenesis and clinical outcomes. We aimed to uncover the intrinsic expression profiles...

    Authors: Chao Guo, Ya-yue Gao, Qian-qian Ju, Chun-xia Zhang, Ming Gong and Zhen-ling Li

    Citation: Journal of Translational Medicine 2021 19:228

    Content type: Research

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  31. Alcohol consumption is one of the modifiable risk factors for intracerebral hemorrhage, which accounts for approximately 10–20% of all strokes worldwide. We evaluated the association of stroke with genetic pol...

    Authors: Chun-Hsiang Lin, Oswald Ndi Nfor, Chien-Chang Ho, Shu-Yi Hsu, Disline Manli Tantoh, Yi-Chia Liaw, Mochly-Rosen Daria, Che-Hong Chen and Yung-Po Liaw

    Citation: Journal of Translational Medicine 2021 19:227

    Content type: Research

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  32. Circular RNAs (circRNAs) are a new class of noncoding RNAs that have gained increased attention in human tumor research. However, the identification and function of circRNAs are largely unknown in the context ...

    Authors: Zhijie Dong, Zhaoyu Liu, Min Liang, Jinhui Pan, Mingzhen Lin, Hai Lin, Yuanwei Luo, Xinke Zhou and Wenxia Yao

    Citation: Journal of Translational Medicine 2021 19:226

    Content type: Research

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  33. Transfusion-related immunomodulation (TRIM) can be caused by exosomes, in which case, microRNAs (miRNAs) are one critical factor impacting exosome behavior. This study aims to investigate and analyze the expre...

    Authors: Yujie Kong, Xue Tian, Rui He, Chenyue Li, Haixia Xu, Li Tian and Zhong Liu

    Citation: Journal of Translational Medicine 2021 19:225

    Content type: Research

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  34. It has been established that microRNA (miR)-449a is anti-tumorigenic in cancers, including lung cancer. Therefore, this study further explored miR-449a-mediated mechanism in lung cancer, mainly focusing on lys...

    Authors: Shan Hu, Peng Cao, Kangle Kong, Peng Han, Yu Deng, Fan Li and Bo Zhao

    Citation: Journal of Translational Medicine 2021 19:224

    Content type: Research

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  35. Experimental autoimmune encephalomyelitis (EAE) is a model for inflammatory demyelinating diseases of the central nervous system (CNS), a group of autoimmune diseases characterized by inflammatory infiltration...

    Authors: Yishu Wang, Chong Xie, Yaying Song, Weiwei Xiang, Jing Peng, Lu Han, Jie Ding and Yangtai Guan

    Citation: Journal of Translational Medicine 2021 19:223

    Content type: Research

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  36. The main limitation of current immune checkpoint inhibitors (ICIs) in the treatment of cervical cancer comes from the fact that it benefits only a minority of patients. The study aims to develop a classificati...

    Authors: Yimin Li, Shun Lu, Shubin Wang, Xinhao Peng and Jinyi Lang

    Citation: Journal of Translational Medicine 2021 19:222

    Content type: Research

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  37. Until now, epidemiological evidence regarding the association between vitamin C intake (both diet and supplements) and Parkinson’s disease (PD) remains inconsistent. Hence, it is necessary to establish the cau...

    Authors: Haijie Liu, Yan Zhang, Haihua Zhang, Longcai Wang, Tao Wang, Zhifa Han, Liyong Wu and Guiyou Liu

    Citation: Journal of Translational Medicine 2021 19:221

    Content type: Research

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  38. The phytocannabinoid cannabidiol (CBD) exhibits anxiolytic activity and has been promoted as a potential treatment for post-traumatic stress disorders. How does CBD interact with the brain to alter behavior? W...

    Authors: Aymen H. Sadaka, Ana G. Ozuna, Richard J. Ortiz, Praveen Kulkarni, Clare T. Johnson, Heather B. Bradshaw, Bruce S. Cushing, Ai-Ling Li, Andrea G. Hohmann and Craig F. Ferris

    Citation: Journal of Translational Medicine 2021 19:220

    Content type: Research

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  39. Generally, cancer cells undergo metabolic reprogramming to adapt to energetic and biosynthetic requirements that support their uncontrolled proliferation. However, the mutual relationship between two critical ...

    Authors: Guoshu Bi, Yunyi Bian, Jiaqi Liang, Jiacheng Yin, Runmei Li, Mengnan Zhao, Yiwei Huang, Tao Lu, Cheng Zhan, Hong Fan and Qun Wang

    Citation: Journal of Translational Medicine 2021 19:219

    Content type: Research

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  40. Post-translational modification (PTM) is a biological process that alters proteins and is therefore involved in the regulation of various cellular activities and pathogenesis. Protein phosphorylation is an ess...

    Authors: Salma Jamal, Waseem Ali, Priya Nagpal, Abhinav Grover and Sonam Grover

    Citation: Journal of Translational Medicine 2021 19:218

    Content type: Research

    Published on:

  41. Citation: Journal of Translational Medicine 2021 19:217

    Content type: Correction

    Published on:

    The original article was published in Journal of Translational Medicine 2021 19:50

  42. Eukaryotic translation initiation factor 6 (eIF6) has a crucial function in the maturation of 60S ribosomal subunits, and it controls the initiation of protein translation. Although emerging studies indicate t...

    Authors: Liping Sun, Shuguang Liu, Xiaopai Wang, Xuefeng Zheng, Ya Chen and Hong Shen

    Citation: Journal of Translational Medicine 2021 19:216

    Content type: Research

    Published on:

  43. The fecal microbiota in pancreatic ductal adenocarcinoma (PDAC) and in autoimmune pancreatitis (AIP) patients remains largely unknown. We aimed to characterize the fecal microbiota in patients with PDAC and AI...

    Authors: Wenli Zhou, De Zhang, Zhengpeng Li, Huiqing Jiang, Jingnan Li, Rongrong Ren, Xuefeng Gao, Jianfeng Li, Xin Wang, Weifeng Wang and Yunsheng Yang

    Citation: Journal of Translational Medicine 2021 19:215

    Content type: Research

    Published on:

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