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  1. Content type: Research

    Recently, circular RNAs (circRNAs) have been reported to be microRNA sponges and play essential roles in cancer development. This study aimed to evaluate whether circulating circRNAs could be used as diagnosti...

    Authors: Xiao-Xia Liu, Yi-E Yang, Xiao Liu, Meng-Yu Zhang, Rui Li, Yun-Hong Yin and Yi-Qing Qu

    Citation: Journal of Translational Medicine 2019 17:50

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  2. Content type: Research

    Obesity is associated with impaired glucose tolerance which is a risk factor for cardiovascular risk. However, the oral glucose tolerance test (OGTT) is not usually performed in patients with normal fasting gl...

    Authors: Belén Pérez-Pevida, Jorge M. Núñez-Córdoba, Sonia Romero, Alexander Dimitri Miras, Patricia Ibañez, Neus Vila, María Ángeles Margall, Camilo Silva, Javier Salvador, Gema Frühbeck and Javier Escalada

    Citation: Journal of Translational Medicine 2019 17:48

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  3. Content type: Research

    Immunology research, particularly next generation sequencing (NGS) of the immune T-cell receptor β (TCRβ) repertoire, has advanced progression in several fields, including treatment of various cancers and auto...

    Authors: Shang-Gin Wu, Wenjing Pan, Hongna Liu, Miranda L. Byrne-Steele, Brittany Brown, Mollye Depinet, Xiaohong Hou, Jian Han and Song Li

    Citation: Journal of Translational Medicine 2019 17:47

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  4. Content type: Research

    Although previous prevalence studies of DED were reported from some countries worldwide, national data are unavailable in China. We aimed to conduct an up-to-date national survey on the prevalence of DED in Ch...

    Authors: Donghui Yu, Qinglong Deng, Jiwei Wang, Xing Chang, Shuxiao Wang, Renren Yang, Jinming Yu and Jing Yu

    Citation: Journal of Translational Medicine 2019 17:46

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  5. Content type: Research

    Atrial fibrillation (AF) is one of the most prevalent sustained arrhythmias, however, epidemiological data may understate its actual prevalence. Meanwhile, AF is considered to be a major cause of ischemic stro...

    Authors: Rongjun Zou, Dingwen Zhang, Lei Lv, Wanting Shi, Zijiao Song, Bin Yi, Bingjia Lai, Qian Chen, Songran Yang and Ping Hua

    Citation: Journal of Translational Medicine 2019 17:45

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  6. Content type: Editorial

    Changes and transformations enabled by Big Data have direct effects on Translational Medicine. At one end, superior precision is expected from a more data-intensive and individualized medicine, thus accelerati...

    Authors: Enrico Capobianco

    Citation: Journal of Translational Medicine 2019 17:44

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  7. Content type: Research

    Sequence information generated from next generation sequencing is often computationally phased using haplotype-phasing algorithms. Utilizing experimentally derived allele or haplotype information improves this...

    Authors: Kshitij Srivastava, Kurt R. Wollenberg and Willy A. Flegel

    Citation: Journal of Translational Medicine 2019 17:43

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  8. Content type: Research

    Marshallese face significant health disparities, with particularly high rates of type 2 diabetes. Engaging stakeholders in the research process is essential to reduce health inequities.

    Authors: Pearl A. McElfish, Britni L. Ayers, Holly C. Felix, Christopher R. Long, Zoran Bursac, Joseph Keawe‘aimoku Kaholokula, Sheldon Riklon, Williamina Bing, Anita Iban and Karen Hye-cheon Kim Yeary

    Citation: Journal of Translational Medicine 2019 17:42

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  9. Content type: Research

    Patients with Idiopathic membranous nephropathy (IMN) have various outcomes. The aim of this study is to construct a tool for clinicians to precisely predict outcome of IMN.

    Authors: Hu Xiaofan, Xu Jing, Gao Chenni, Wu Yifan, Yu Xialian, Lin Li, Ren Hong, Zhang Wen, Wang Weiming, Pan Xiaoxia, Xie Jingyuan and Chen Nan

    Citation: Journal of Translational Medicine 2019 17:41

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  10. Content type: Research

    Acute myocardial infarction (AMI) is characterized by an inflammatory process in which T cell plays a key role. However, the profile of immune microenvironment in AMI is still uncertain. High-throughput sequen...

    Authors: Dan Li, Longgang Hu, Qing Liang, Cuijuan Zhang, Yunzhen Shi, Bin Wang and Kejia Wang

    Citation: Journal of Translational Medicine 2019 17:40

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  11. Content type: Methodology

    One of the key reasons for the high failure rate of new agents and low therapeutic benefit of approved treatments is the lack of preclinical models that mirror the biology of human tumors. At present, the opti...

    Authors: Quanxue Li, Wentao Dai, Jixiang Liu, Yi-Xue Li and Yuan-Yuan Li

    Citation: Journal of Translational Medicine 2019 17:39

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  12. Content type: Research

    Coronary artery disease (CAD) is the leading cause of morbidity and mortality in patients with type 2 diabetes mellitus (T2DM). The purpose of the present study was to discriminate the Indian CAD patients with...

    Authors: Ramu Adela, Podduturu Naveen Chander Reddy, Tarini Shankar Ghosh, Suruchi Aggarwal, Amit Kumar Yadav, Bhabatosh Das and Sanjay K. Banerjee

    Citation: Journal of Translational Medicine 2019 17:17

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  13. Content type: Research

    The altered concentrations of amino acids were found in the bone marrow or blood of leukemia patients. Metabolomics technology combining mathematical model of biomarkers could be used for assisting the diagnos...

    Authors: Zhidai Liu, Tingting Zhou, Xing Han, Tingyuan Lang, Shan Liu, Penghui Zhang, Haiyan Liu, Kexing Wan, Jie Yu, Liang Zhang, Liyan Chen, Roger W. Beuerman, Bin Peng, Lei Zhou and Lin Zou

    Citation: Journal of Translational Medicine 2019 17:38

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  14. Content type: Research

    Systemic lupus erythematosus (SLE) is a prototypic autoimmune disease characterized by the presence of pathogenic autoantibodies associated with polyclonal B cell hyperreactivity. Previous study reported that ...

    Authors: Meiyu Zhang, Chengcheng Yao, Jun Cai, Shuai Liu, Xia-nan Liu, Yingying Chen, Shujun Wang, Ping Ji, Meng Pan, Zizhen Kang and Ying Wang

    Citation: Journal of Translational Medicine 2019 17:37

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  15. Content type: Research

    Tissue expansion is a procedure that promotes skin regeneration by mechanical stretch. During the stress and relaxation cycle, the skin undergoes a repeated microtrauma which triggers an immune response leadin...

    Authors: Jianke Ding, Lei Lei, Shiqiang Liu, Yu Zhang, Zhou Yu, Yingjun Su and Xianjie Ma

    Citation: Journal of Translational Medicine 2019 17:36

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  16. Content type: Research

    Despite that most HIV-infected individuals experience progressive CD4+ T cell loss and develop AIDS, a minority of HIV-infected individuals remain asymptomatic and maintain high level CD4+ T cell counts severa...

    Authors: Jiwei Ding, Ling Ma, Jianyuan Zhao, Yongli Xie, Jinming Zhou, Xiaoyu Li and Shan Cen

    Citation: Journal of Translational Medicine 2019 17:35

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  17. Content type: Research

    With over 800 million cases globally, campylobacteriosis is a major cause of food borne disease. In temperate climates incidence is highly seasonal but the underlying mechanisms are poorly understood, making h...

    Authors: Stephen P. Rushton, Roy A. Sanderson, Peter J. Diggle, Mark D. F. Shirley, Alasdair P. Blain, Iain Lake, James A. Maas, William D. K. Reid, Jo Hardstaff, Nicola Williams, Natalia R. Jones, Daniel Rigby, Norval J. C. Strachan, Ken J. Forbes, Paul R. Hunter, Thomas J. Humphrey…

    Citation: Journal of Translational Medicine 2019 17:34

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  18. Content type: Review

    Ischemia–reperfusion injury is caused by a period of ischemia followed by massive blood flow into a tissue that had experienced restricted blood flow. The severity of the injury is dependent on the time the ti...

    Authors: Michael D. Wetzel and Joseph C. Wenke

    Citation: Journal of Translational Medicine 2019 17:33

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  19. Content type: Research

    Circulating tumor cells (CTC) shows great prospect to realize precision medicine in cancer patients.

    Authors: Weiling He, Di Xu, Zhuo Wang, Hui Wu, Xianhong Xiang, Bing Tang, Wenting Jiang, Yongmei Cui, Han Wang, Neng Jiang, Yu Sun, Yangshan Chen, Shuhua Li, Minzhi Hou, Yang Zhang, Liantang Wang…

    Citation: Journal of Translational Medicine 2019 17:32

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  20. Content type: Research

    Systemic inflammation and immune dysfunction have been proved to be associated with cancer progression and metastasis in various malignancies. The aim of this retrospective study was to evaluate the prognostic...

    Authors: Ke Zhang, Yong-Qiang Hua, Dan Wang, Lian-Yu Chen, Cai-Jun Wu, Zhen Chen, Lu-Ming Liu and Hao Chen

    Citation: Journal of Translational Medicine 2019 17:30

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  21. Content type: Research

    We set out to determine if the administration of subcutaneous (SQ) ALT-803 was non-inferior to standard intravesical BCG treatment in a carcinogen induced mouse (C57BL/6J) bladder cancer model.

    Authors: Hideki Furuya, Owen T. M. Chan, Ian Pagano, Chengjun Zhu, Nari Kim, Rafael Peres, Kanani Hokutan, Sarah Alter, Peter Rhode and Charles J. Rosser

    Citation: Journal of Translational Medicine 2019 17:29

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  22. Content type: Review

    Accumulated evidence has demonstrated that WNT1 inducible signaling pathway protein (WISP) genes, which belong to members of the CCN growth factor family, play a pivotal role in tumorigenesis and progression o...

    Authors: Yi Liu, Yizuo Song, Miaomiao Ye, Xiaoli Hu, Z. Peter Wang and Xueqiong Zhu

    Citation: Journal of Translational Medicine 2019 17:28

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  23. Content type: Research

    Among breast cancer (BC) patients, near 40% are post-menopause, and 70%–80% are hormone receptor (HR)-positive. About 30%–40% BC patients who are diagnosed as invasive carcinoma HR-positive BC would eventually...

    Authors: Jingyu Liu, Jing Li, Hui Wang, Yikai Wang, Qiongzhi He, Xuefeng Xia, Zhe-Yu Hu and Quchang Ouyang

    Citation: Journal of Translational Medicine 2019 17:27

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  24. Content type: Research

    Renal transplantation is increasingly associated with the presence of comorbidity factors such as dyslipidemia which could influence the graft outcome. We hypothesized that hypercholesterolemia could affect va...

    Authors: Thomas Kerforne, Frédéric Favreau, Tackwa Khalifeh, Souleymane Maiga, Geraldine Allain, Antoine Thierry, Manuel Dierick, Edouard Baulier, Clara Steichen and Thierry Hauet

    Citation: Journal of Translational Medicine 2019 17:26

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  25. Content type: Research

    Vascular grafts are widely used as a treatment in coronary artery bypass surgery, hemodialysis, peripheral arterial bypass and congenital heart disease. Various types of synthetic and natural materials were ex...

    Authors: Tao Wang, Nianguo Dong, Huimin Yan, Sze Yue Wong, Wen Zhao, Kang Xu, Dong Wang, Song Li and Xuefeng Qiu

    Citation: Journal of Translational Medicine 2019 17:24

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  26. Content type: Research

    Bone marrow stromal cells (BMSCs) are a heterogeneous population that participates in wound healing, immune modulation and tissue regeneration. Next generation sequencing was used to analyze transcripts from s...

    Authors: Shutong Liu, David F. Stroncek, Yingdong Zhao, Victoria Chen, Rongye Shi, Jinguo Chen, Jiaqiang Ren, Hui Liu, Hee Joon Bae, Steven L. Highfill and Ping Jin

    Citation: Journal of Translational Medicine 2019 17:23

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  27. Content type: Research

    Vascular shear stress promotes endothelial cell sprouting in vitro. The impact of hemodynamic forces on microRNA (miRNA) and gene expression within growing vascular networks in vivo, however, remain poorly inv...

    Authors: Dominic Henn, Masood Abu-Halima, Dominik Wermke, Florian Falkner, Benjamin Thomas, Christoph Köpple, Nicole Ludwig, Matthias Schulte, Marc A. Brockmann, Yoo-Jin Kim, Justin M. Sacks, Ulrich Kneser, Andreas Keller, Eckart Meese and Volker J. Schmidt

    Citation: Journal of Translational Medicine 2019 17:22

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  28. Content type: Research

    T cells are key regulators of immunity and one of the cells recruited in atherosclerosis and participated in various stages of the development of atherosclerosis. Characterizing T-cell receptor (TCR) repertoir...

    Authors: Zhixiong Zhong, Heming Wu, Qifeng Zhang, Wei Zhong and Pingsen Zhao

    Citation: Journal of Translational Medicine 2019 17:21

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  29. Content type: Research

    Melanoma cells develop adaptive responses in order to cope with particular conditions of tumor microenvironment, characterized by stress conditions and deregulated proliferation. Recently, the interplay betwee...

    Authors: Immacolata Maida, Paola Zanna, Stefania Guida, Anna Ferretta, Tiziana Cocco, Luigi Leonardo Palese, Paola Londei, Dario Benelli, Amalia Azzariti, Stefania Tommasi, Michele Guida, Giovanni Pellacani and Gabriella Guida

    Citation: Journal of Translational Medicine 2019 17:20

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  30. Content type: Research

    Gene transfer to malignant sites using human adenoviruses (hAds) has been limited because of their immunogenic nature and host specificity. Murine cells often lack some of the receptors needed for hAds attachm...

    Authors: Flavia De Carlo, Litty Thomas, Bell Brooke, Elliot T. Varney, Rounak Nande, Olivia Boskovic, Gailen D. Marshall, Pier Paolo Claudio and Candace M. Howard

    Citation: Journal of Translational Medicine 2019 17:19

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  31. Content type: Research

    Spondyloarthritis (SpA) is chronic inflammatory arthritis, and interleukin (IL)-17 is crucial in SpA pathogenesis. Type 17 helper T (Th17) cells are one of major IL-17-secreting cells. Signal transducer and ac...

    Authors: Hong-Ki Min, JeongWon Choi, Seon-Yeong Lee, Hyeon-Beom Seo, KyungAh Jung, Hyun Sik Na, Jun-Geol Ryu, Seung-Ki Kwok, Mi-La Cho and Sung-Hwan Park

    Citation: Journal of Translational Medicine 2019 17:18

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  32. Content type: Research

    Early life is a period of drastic epigenetic remodeling in which the epigenome is especially sensitive to extrinsic and intrinsic influence. However, the epigenome-wide dynamics of the DNA methylation changes ...

    Authors: Raúl F. Pérez, Pablo Santamarina, Juan Ramón Tejedor, Rocío G. Urdinguio, Julio Álvarez-Pitti, Pau Redon, Agustín F. Fernández, Mario F. Fraga and Empar Lurbe

    Citation: Journal of Translational Medicine 2019 17:15

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  33. Content type: Research

    Despite much progress in cancer research, its incidence and mortality continue to rise. A robust biomarker that would predict tumor behavior is highly desirable and could improve patient treatment and prognosis.

    Authors: Wai Hoong Chang, Donall Forde and Alvina G. Lai

    Citation: Journal of Translational Medicine 2019 17:14

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  34. Content type: Research

    The immune tumor microenvironment (iTME) is thought to affect the response to chemotherapy, and tumor-infiltrating lymphocytes (TILs) are often used as an indicator to evaluate the iTME. Smoking is involved in...

    Authors: Koji Takada, Shinichiro Kashiwagi, Yuka Asano, Wataru Goto, Katsuyuki Takahashi, Hisakazu Fujita, Tsutomu Takashima, Shuhei Tomita, Kosei Hirakawa and Masaichi Ohira

    Citation: Journal of Translational Medicine 2019 17:13

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  35. Content type: Research

    The epithelial to mesenchymal transition (EMT) is a multi-factorial biological mechanism involved in renal and hepatic fibrosis and the IL-1 beta has been assumed as a mediator of this process although data ar...

    Authors: Valentina Masola, Amedeo Carraro, Simona Granata, Lorenzo Signorini, Gloria Bellin, Paola Violi, Antonio Lupo, Umberto Tedeschi, Maurizio Onisto, Giovanni Gambaro and Gianluigi Zaza

    Citation: Journal of Translational Medicine 2019 17:12

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  36. Content type: Research

    A clinical diagnosis model include thyroid functions, thyroid antibodies and radioactive iodine uptake (RAIU) of patients with hyperthyroidism were established and as new evaluation indicators for the differen...

    Authors: Zhaohui Cui, Zhixiao Wang, Xiaoyun Liu, Yun Cai, Xinyu Xu and Tao Yang

    Citation: Journal of Translational Medicine 2019 17:11

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  37. Content type: Research

    This study examined the quality of bone marrow aspirates extracted using a novel, FDA cleared method to optimally target cells from the inner cortical iliac bone surface without the need for centrifugation. Th...

    Authors: Michael Scarpone, Daniel Kuebler, Andrew Chambers, Carlo Maria De Filippo, Mariangela Amatuzio, Thomas E. Ichim, Amit N. Patel and Eugenio Caradonna

    Citation: Journal of Translational Medicine 2019 17:10

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  38. Content type: Research

    The triple negative breast cancer (TNBC) paradox marks a major challenge in the treatment-decision making process. TNBC patients generally respond better to neoadjuvant chemotherapy compared to other breast ca...

    Authors: Ghaneya Al-Khadairi, Adviti Naik, Remy Thomas, Boshra Al-Sulaiti, Shaheen Rizly and Julie Decock

    Citation: Journal of Translational Medicine 2019 17:9

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  39. Content type: Research

    Intramuscular triglycerides (IMTGs) represent an important energy supply and a dynamic fat-storage depot that can expand during periods of elevated lipid availability and a fatty acid source. Ultrasonography (...

    Authors: Giovanni Tarantino, Susan Costantini, Vincenzo Citro, Paolo Conforti, Francesca Capone, Angela Sorice and Domenico Capone

    Citation: Journal of Translational Medicine 2019 17:8

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  40. Content type: Research

    Hepatitis B virus (HBV) is one of the major risk factors of hepatocellular carcinoma (HCC). Increasing evidence indicates that microRNA (miRNA)–mRNA axis is involved in HCC. However, a comprehensive miRNA–mRNA...

    Authors: Weiyang Lou, Jingxing Liu, Bisha Ding, Danni Chen, Liang Xu, Jun Ding, Donghai Jiang, Lin Zhou, Shusen Zheng and Weimin Fan

    Citation: Journal of Translational Medicine 2019 17:7

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  41. Content type: Methodology

    Hepatitis B virus (HBV) infections represent a global health problem and chronic hepatitis B (CHB) leads to liver cirrhosis and hepatocellular carcinoma. Thus, timely diagnosis of hepatitis B is crucial to ens...

    Authors: Katharina Bröker, Robin Terzenbach, Frank Bentzien, Stefan Lüth and Werner Dammermann

    Citation: Journal of Translational Medicine 2019 17:6

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  42. Content type: Review

    Dysbiosis represents changes in composition and structure of the gut microbiome community (microbiome), which may dictate the physiological phenotype (health or disease). Recent technological advances and effo...

    Authors: Yuan-Yuan Chen, Dan-Qian Chen, Lin Chen, Jing-Ru Liu, Nosratola D. Vaziri, Yan Guo and Ying-Yong Zhao

    Citation: Journal of Translational Medicine 2019 17:5

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  43. Content type: Research

    Total temporomandibular joint (TMJ) prosthesis is an effective and reliable method of joint reconstruction. However, there is still an urgent need to design a new TMJ prosthesis because of no commercially avai...

    Authors: JiSi Zheng, XuZhuo Chen, WenBo Jiang, ShanYong Zhang, MinJie Chen and Chi Yang

    Citation: Journal of Translational Medicine 2019 17:4

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  44. Content type: Research

    The common treatment for pediatric cataracts is to replace the cloudy lens with an artificial one. However, patients may suffer complications (severe lens proliferation into the visual axis and abnormal high i...

    Authors: Kai Zhang, Xiyang Liu, Jiewei Jiang, Wangting Li, Shuai Wang, Lin Liu, Xiaojing Zhou and Liming Wang

    Citation: Journal of Translational Medicine 2019 17:2

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  45. Content type: Research

    Neoadjuvant chemotherapy (NAC) has become the standard of care for resectable esophageal squamous cell carcinoma (ESCC) which is one of the most lethal cancers, to improve resectability and prognosis. On this ...

    Authors: Yukiko Niwa, Suguru Yamada, Fuminori Sonohara, Keisuke Kurimoto, Masamichi Hayashi, Mitsuru Tashiro, Naoki Iwata, Mitsuro Kanda, Chie Tanaka, Daisuke Kobayashi, Goro Nakayama, Masahiko Koike, Michitaka Fujiwara and Yasuhiro Kodera

    Citation: Journal of Translational Medicine 2019 17:1

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