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  1. Content type: Research

    Molecularly targeted therapies using receptor inhibitors, small molecules or monoclonal antibodies are routinely applied in oncology. Verification of target expression should be mandatory prior to initiation o...

    Authors: Niklas Schäfer, Gerrit H. Gielen, Laurèl Rauschenbach, Sied Kebir, Andreas Till, Roman Reinartz, Matthias Simon, Pitt Niehusmann, Christoph Kleinschnitz, Ulrich Herrlinger, Torsten Pietsch, Björn Scheffler and Martin Glas

    Citation: Journal of Translational Medicine 2019 17:96

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  2. Content type: Research

    Oxidized low-density lipoproteins and scavenger receptors (SRs) play an important role in the formation and development of atherosclerotic plaques. However, little is known about their presence in epicardial a...

    Authors: Concepción Santiago-Fernández, Luis M. Pérez-Belmonte, Mercedes Millán-Gómez, Inmaculada Moreno-Santos, Fernando Carrasco-Chinchilla, Amalio Ruiz-Salas, Luis Morcillo-Hidalgo, José M. Melero, Lourdes Garrido-Sánchez and Manuel Jiménez-Navarro

    Citation: Journal of Translational Medicine 2019 17:95

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  3. Content type: Research

    Chronic hepatitis C virus (HCV)-infection is a slowly debilitating and potentially fatal disease with a high estimated number of undiagnosed cases. Given the major advances in the treatment, detection of unrep...

    Authors: Markus Reiser, Bianka Wiebner and Jürgen Hirsch

    Citation: Journal of Translational Medicine 2019 17:94

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  4. Content type: Research

    Prostaglandin E receptor 2 (EP2) is an immune modulatory molecule that regulates the balance of immunity. Here we investigated the role of EP2 in immune dysregulation in patients with acute-on-chronic liver fa...

    Authors: Yunyun Wang, Chao Chen, Jinjin Qi, Fengtian Wu, Jun Guan, Zhi Chen and Haihong Zhu

    Citation: Journal of Translational Medicine 2019 17:93

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  5. Content type: Research

    Identifying intestinal node-negative gastric adenocarcinoma (INGA) patients with high risk of recurrence could help perceive benefit of adjuvant therapy for INGA patients following surgical resection. This stu...

    Authors: Meng-Yao Ji, Lei Yuan, Xiao-Da Jiang, Zhi Zeng, Na Zhan, Ping-Xiao Huang, Cheng Lu and Wei-Guo Dong

    Citation: Journal of Translational Medicine 2019 17:92

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  6. Content type: Research

    Hyperoxia-induced bronchopulmonary dysplasia (BPD) models are essential for better understanding and impacting on long-term pulmonary, cardiovascular, and neurological sequelae of this chronic disease. Only fe...

    Authors: Francesco Greco, Susanne Wiegert, Philipp Baumann, Sven Wellmann, Giovanni Pellegrini and Vincenzo Cannizzaro

    Citation: Journal of Translational Medicine 2019 17:91

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  7. Content type: Research

    Hypercoagulation and neutrophilia are described in several cancers, however, whether they are involved in lung carcinogenesis is currently unknown. Emodin is the main bioactive component from Rheum palmatum an...

    Authors: Zibo Li, Yukun Lin, Shuhui Zhang, Lin Zhou, Guixi Yan, Yuehua Wang, Mengdi Zhang, Mengqi Wang, Haihong Lin, Qiaozhen Tong, Yongjian Duan and Gangjun Du

    Citation: Journal of Translational Medicine 2019 17:90

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  8. Content type: Research

    Artificial meniscal implants can be used to replace a severely injured meniscus after meniscectomy and restore the normal functionality of a knee joint. The aim of this paper was to design porous meniscal impl...

    Authors: Li-ya Zhu, Lan Li, Zong-an Li, Jian-ping Shi, Wen-lai Tang, Ji-quan Yang and Qing Jiang

    Citation: Journal of Translational Medicine 2019 17:89

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  9. Content type: Research

    Excess dietary sodium is not only excreted by the kidneys, but can also be stored by non-osmotic binding with glycosaminoglycans in dermal connective tissue. Such storage has been associated with dermal inflam...

    Authors: Ryanne S. Hijmans, Marco van Londen, Kwaku A. Sarpong, Stephan J. L. Bakker, Gerjan J. Navis, Twan T. R. Storteboom, Wilhelmina H. A. de Jong, Robert A. Pol and Jacob van den Born

    Citation: Journal of Translational Medicine 2019 17:88

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  10. Content type: Review

    Human growth is a complex mechanism that depends on genetic, environmental, nutritional and hormonal factors. The main hormone involved in growth at each stage of development is growth hormone (GH) and its med...

    Authors: Susanna Esposito, Alberto Leonardi, Lucia Lanciotti, Marta Cofini, Giulia Muzi and Laura Penta

    Citation: Journal of Translational Medicine 2019 17:87

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  11. Content type: Research

    Chronic kidney disease (CKD) leads to end-stage renal failure and cardiovascular events. An attribute to these progressions is abnormalities in inflammation, which can be evaluated using the neutrophil-to-lymp...

    Authors: Qiongjing Yuan, Jinwei Wang, Zhangzhe Peng, Qiaoling Zhou, Xiangcheng Xiao, Yanyun Xie, Wei Wang, Ling Huang, Wenbin Tang, Danni Sun, Luxia Zhang, Fang Wang, Ming-Hui Zhao, Lijian Tao, Kevin He and Hui Xu

    Citation: Journal of Translational Medicine 2019 17:86

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  12. Content type: Research

    Rheumatoid arthritis (RA) is a chronic and systemic inflammatory disease characterized by upregulation of inflammatory cell death and osteoclastogenesis. Necrostatin (NST)-1s is a chemical inhibitor of recepto...

    Authors: Jooyeon Jhun, Seung Hoon Lee, Se-Young Kim, Jaeyoon Ryu, Ji Ye Kwon, Hyun Sik Na, KyoungAh Jung, Su-Jin Moon, Mi-La Cho and Jun-Ki Min

    Citation: Journal of Translational Medicine 2019 17:84

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  13. Content type: Correction

    Following publication of the original article [1], the authors reported updated affiliations for five of the authors. The updated affiliations are shown below and reflected in the affiliation list of this Corr...

    Authors: C. Tersigni, S. D’Ippolito, F. Di Nicuolo, R. Marana, V. Valenza, V. Masciullo, F. Scaldaferri, F. Malatacca, C. de Waure, A. Gasbarrini, G. Scambia and N. Di Simone

    Citation: Journal of Translational Medicine 2019 17:83

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    The original article was published in Journal of Translational Medicine 2018 16:102

  14. Content type: Methodology

    Monocytes are myeloid cells that reside in the blood and bone marrow and respond to inflammation. At the site of inflammation, monocytes express cytokines and chemokines. Monocytes have been shown to be cytoto...

    Authors: Daniel S. Green, Ana T. Nunes, Kevin W. Tosh, Virginia David-Ocampo, Vicki S. Fellowes, Jiaqiang Ren, Jianjian Jin, Sue-Ellen Frodigh, Chauha Pham, Jolynn Procter, Celina Tran, Irene Ekwede, Hanh Khuu, David F. Stroncek, Steven L. Highfill, Kathryn C. Zoon…

    Citation: Journal of Translational Medicine 2019 17:82

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  15. Content type: Research

    Therapeutic plasma exchange (PE) or plasmapheresis is an extracorporeal procedure employed to treat immunological disorders. Exosomes, nanosized vesicles of endosomal origin, mediate intercellular communicatio...

    Authors: Sujay Ramanathan, Sabrina R. Douglas, Guillermo M. Alexander, Botros B. Shenoda, James E. Barrett, Enrique Aradillas, Ahmet Sacan and Seena K. Ajit

    Citation: Journal of Translational Medicine 2019 17:81

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  16. Content type: Research

    There are no known objective biomarkers to assist with the diagnosis of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS). A small number of studies have shown that ME/CFS patients exhibit an earlier...

    Authors: Maximillian J. Nelson, Jonathan D. Buckley, Rebecca L. Thomson, Daniel Clark, Richard Kwiatek and Kade Davison

    Citation: Journal of Translational Medicine 2019 17:80

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  17. Content type: Research

    Covalent RNA modifications, such as N-6-methyladenosine (m6A), have been associated with various biological processes, but their role in cancer remains largely unexplored. m6A dynamics depends on specific enzymes...

    Authors: João Lobo, Ana Laura Costa, Mariana Cantante, Rita Guimarães, Paula Lopes, Luís Antunes, Isaac Braga, Jorge Oliveira, Mattia Pelizzola, Rui Henrique and Carmen Jerónimo

    Citation: Journal of Translational Medicine 2019 17:79

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  18. Content type: Research

    Changes in brain metabolism has been investigated thoroughly during unilateral cervical chronic vagal stimulation in epileptic or depressive patients. Bilateral stimulation of the abdominal vagus (aVNS) has recei...

    Authors: Charles-Henri Malbert, Mickael Genissel, Jean-Louis Divoux and Christine Henry

    Citation: Journal of Translational Medicine 2019 17:78

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  19. Content type: Review

    There are no guidelines concerning the best approach to improving sleep, but it has been shown that it can benefit the affected children and their entire families. The aim of this review is to analyse the effi...

    Authors: Susanna Esposito, Daniela Laino, Renato D’Alonzo, Annalisa Mencarelli, Lorenza Di Genova, Antonella Fattorusso, Alberto Argentiero and Elisabetta Mencaroni

    Citation: Journal of Translational Medicine 2019 17:77

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  20. Content type: Research

    Oral squamous cell carcinoma (OSCC) is a common oral and maxillofacial malignant tumor with high rates of metastasis and mortality. Circular RNAs (circRNAs), a type of non-coding RNA, are involved in the devel...

    Authors: Wen Su, Shuai Sun, Feng Wang, Yuehong Shen and Hongyu Yang

    Citation: Journal of Translational Medicine 2019 17:76

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  21. Content type: Methodology

    Extracellular vesicles (EVs) are small membrane-bound vesicles which play an important role in cell-to-cell communication. Their molecular cargo analysis is presented as a new source for biomarker detection, a...

    Authors: N. García-Romero, R. Madurga, G. Rackov, I. Palacín-Aliana, R. Núñez-Torres, A. Asensi-Puig, J. Carrión-Navarro, S. Esteban-Rubio, H. Peinado, A. González-Neira, V. González-Rumayor, C. Belda-Iniesta and A. Ayuso-Sacido

    Citation: Journal of Translational Medicine 2019 17:75

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  22. Content type: Research

    CEA, CYFRA21-1 and NSE are tumor markers used for monitoring the response to chemotherapy in advanced adenocarcinoma, squamous cell carcinoma and small-cell lung cancer, respectively. Their role in cancer immu...

    Authors: M. G. Dal Bello, R. A. Filiberti, A. Alama, A. M. Orengo, M. Mussap, S. Coco, I. Vanni, S. Boccardo, E. Rijavec, C. Genova, F. Biello, G. Barletta, G. Rossi, M. Tagliamento, C. Maggioni and F. Grossi

    Citation: Journal of Translational Medicine 2019 17:74

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  23. Content type: Research

    Previous studies from this as well as other research groups suggested that non-invasive chromosome screening (NICS) with embryo culture medium can be used to identify chromosomal ploidy and chromosomal abnorma...

    Authors: Rui Fang, Weimin Yang, Xin Zhao, Fang Xiong, Caiqing Guo, Jianping Xiao, Li Chen, Xiaoqing Song, Honghua Wang, Jie Chen, Xiao Xiao, Bing Yao and Li-Yi Cai

    Citation: Journal of Translational Medicine 2019 17:73

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  24. Content type: Research

    Mesenchymal stromal cells (MSCs) were originally characterized by the ability to differentiate into different mesenchymal lineages in vitro, and their immunomodulatory and trophic functions have recently arous...

    Authors: Ya-nan Bie, Peng Gu, Yu-ting Chen, Xiao-xu Zhou, Yu-guang Tian, Qin Yang, Hai-yan Li, Xia Lin, Yan-hong Guan, Tao-yan Lin, Xun Lu, Hong-fen Shen, Ting-xiao Fang, Yu-min Liu, Dong Xiao and Wei-Wang Gu

    Citation: Journal of Translational Medicine 2019 17:72

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  25. Content type: Research

    Angiogenesis inhibition research is a cutting edge area in angiogenesis-dependent disease therapy, especially in cancer therapy. Recently, studies on anti-angiogenic peptides have provided promising results in...

    Authors: Javad Zahiri, Babak Khorsand, Ali Akbar Yousefi, Mohammadjavad Kargar, Ramin Shirali Hossein Zade and Ghasem Mahdevar

    Citation: Journal of Translational Medicine 2019 17:71

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  26. Content type: Research

    Lung cancer has become the most common cancer type and caused the most cancer deaths. Lung adenocarcinoma (LUAD) is one of the major type of lung cancer. This study aimed to establish a signature based on immu...

    Authors: Qian Song, Jun Shang, Zuyi Yang, Lanlin Zhang, Chufan Zhang, Jianing Chen and Xianghua Wu

    Citation: Journal of Translational Medicine 2019 17:70

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  27. Content type: Research

    With an increasing indication spectrum of antiresorptive drugs, the medication-related osteonecrosis of the jaw secondary to bisphosphonate therapy [MRONJ (BP)] is continuously gaining clinical relevance. Impa...

    Authors: Falk Wehrhan, Christian Gross, Kay Creutzburg, Kerstin Amann, Jutta Ries, Marco Kesting, Carol-Immanuel Geppert and Manuel Weber

    Citation: Journal of Translational Medicine 2019 17:69

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  28. Content type: Research

    Human amniotic fluid (AF) contains numerous nutrients, trophic factors and defense proteins that provide a nurturing and protective environment for fetal development. Based on reports that AF has antibacterial...

    Authors: Yong Mao, Jan Pierce, Anya Singh-Varma, Michael Boyer, Joachim Kohn and Jo-Anna Reems

    Citation: Journal of Translational Medicine 2019 17:68

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  29. Content type: Research

    Gastrointestinal microbiome has drawn an increasing amount of attention over the past decades. There is emerging evidence that the gut flora plays a major role in the pathogenesis of certain diseases. We aimed...

    Authors: Xiaoquan Huang, Xiaowen Fan, Jun Ying and Shiyao Chen

    Citation: Journal of Translational Medicine 2019 17:67

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  30. Content type: Research

    As the optimal source of seed cells in periodontal tissue engineering, periodontal ligament stem cells (PDLSCs) have always been researched to improve cell expansion due to their limited resource and spontaneo...

    Authors: Chunshu Zhang, Hongmei Guo, Chengzhe Yang, Qian Chen, Jiahui Huang, Lianlian Liu, Yu Zhang, Shanshan Jin, Aimei Song and Pishan Yang

    Citation: Journal of Translational Medicine 2019 17:66

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  31. Content type: Research

    Visible light spectroscopy (VLS) is a technique used to measure the mucosal oxygen saturation during upper gastrointestinal endoscopy to evaluate mucosal ischemia, however in vivo validation is lacking. We aim...

    Authors: Rinse Ubbink, Louisa J. D. van Dijk, Desirée van Noord, Tanja Johannes, Patricia A. C. Specht, Marco J. Bruno and Egbert G. Mik

    Citation: Journal of Translational Medicine 2019 17:65

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  32. Content type: Research

    Osteopenia have been well documented in adolescent idiopathic scoliosis (AIS). Adiponectin has been shown to be inversely proportional to body mass index and to affect bone metabolism. However, the circulating...

    Authors: Hong-qi Zhang, Long-jie Wang, Shao-hua Liu, Jiong Li, Li-ge Xiao and Guan-teng Yang

    Citation: Journal of Translational Medicine 2019 17:64

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  33. Content type: Research

    Currently, pathological examination of gastroscopy biopsy specimens is the gold standard for gastric cancer (GC) diagnosis. However, it has a false-negative rate of 10–20% due to inaccurate sampling locations ...

    Authors: Haidan Yan, Meifeng Li, Longlong Cao, Haifeng Chen, Hungming Lai, Qingzhou Guan, Huxing Chen, Wenbin Zhou, Baotong Zheng, Zheng Guo and Chaohui Zheng

    Citation: Journal of Translational Medicine 2019 17:63

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  34. Content type: Research

    The morbidity of nephrolithiasis is 2–3 times higher in males than in females, suggesting that androgen plays a key role in nephrolithiasis. The death of renal tubular epithelial cells (TECs) is an important p...

    Authors: Yonghan Peng, Ziyu Fang, Min Liu, Zeyu Wang, Ling Li, Shaoxiong Ming, Chaoyue Lu, Hao Dong, Wenhui Zhang, Qi Wang, Rong Shen, Fei Xie, Weitao Zhang, Cheng Yang, Xiaofeng Gao and Yinghao Sun

    Citation: Journal of Translational Medicine 2019 17:62

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  35. Content type: Research

    A hallmark of pancreatic ductal adenocarcinoma is the desmoplastic reaction, but its impact on the tumor behavior remains controversial. Our aim was to introduce a computer -aided method to precisely quantify ...

    Authors: Fabio Grizzi, Sirio Fiorino, Dorina Qehajaj, Adele Fornelli, Carlo Russo, Dario de Biase, Michele Masetti, Laura Mastrangelo, Matteo Zanello, Raffaele Lombardi, Andrea Domanico, Esterita Accogli, Andrea Tura, Leonardo Mirandola, Maurizio Chiriva-Internati, Robert S. Bresalier…

    Citation: Journal of Translational Medicine 2019 17:61

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  36. Content type: Research

    Glycolysis is altered in various kidney diseases, but little is known about glycolysis in pre-eclampsia, a multi-system disorder with major pathological effects on the kidney. Urinary exosomes provide a non-in...

    Authors: R. Ellis, M. Katerelos, S. W. Choy, N. Cook, M. Lee, K. Paizis, G. Pell, S. Walker, D. A. Power and P. F. Mount

    Citation: Journal of Translational Medicine 2019 17:60

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  37. Content type: Research

    Diabetic kidney disease (DKD) is the leading cause of end-stage kidney disease (ESKD) in the world. Emerging evidence has shown that urinary mRNAs may serve as early diagnostic and prognostic biomarkers of DKD...

    Authors: Le-Ting Zhou, Lin-Li Lv, Shen Qiu, Qing Yin, Zuo-Lin Li, Tao-Tao Tang, Li-Hua Ni, Ye Feng, Bin Wang, Kun-Ling Ma and Bi-Cheng Liu

    Citation: Journal of Translational Medicine 2019 17:59

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  38. Content type: Research

    Progesterone resistance is a problem in endometrial carcinoma, and its underlying molecular mechanisms remain poorly understood. The aim of this study was to elucidate the molecular mechanisms of progesterone ...

    Authors: Wenzhi Li, Shufen Wang, Chunping Qiu, Zhiming Liu, Qing Zhou, Deshui Kong, Xiaohong Ma and Jie Jiang

    Citation: Journal of Translational Medicine 2019 17:58

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  39. Content type: Research

    T helper (Th) cells regulate sepsis processes, including primary pathogen clear and secondary pathogen defence. The objectives of this study were to determine the early and dynamic alterations of Th1 and Th2 p...

    Authors: Ming Xue, Jianfeng Xie, Ling Liu, Yingzi Huang, Fengmei Guo, Jingyuan Xu, Yi Yang and Haibo Qiu

    Citation: Journal of Translational Medicine 2019 17:57

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  40. Content type: Research

    Osteosarcoma (OS) is the most common cancer of bone. Jaw osteosarcoma (JOS) is rare and it differs from other OS in terms of the time of occurrence (two decades later) and better survival. The aim of our work ...

    Authors: Hélios Bertin, Romain Guilho, Régis Brion, Jérôme Amiaud, Séverine Battaglia, Anne Moreau, Anne Brouchet-Gomez, Julie Longis, Benoit Piot, Dominique Heymann, Pierre Corre and Françoise Rédini

    Citation: Journal of Translational Medicine 2019 17:56

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  41. Content type: Research

    Similarities in the symptoms of chronic fatigue syndrome (CFS) and inflammatory bowel disease (IBD) have been observed as follows: severe disease activity in IBD correlates with severe fatigue, major psychiatr...

    Authors: Shin-Yi Tsai, Hsuan-Ju Chen, Chon-Fu Lio, Chien-Feng Kuo, An-Chun Kao, Wei-Shieng Wang, Wei-Cheng Yao, Chi Chen and Tse-Yen Yang

    Citation: Journal of Translational Medicine 2019 17:55

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  42. Content type: Review

    In 1975, Milstein and Köhler revolutionized the medical world with the development of the hybridoma technique to produce monoclonal antibodies. Since then, monoclonal antibodies have entered almost every branc...

    Authors: Lien Van Hoecke and Kenny Roose

    Citation: Journal of Translational Medicine 2019 17:54

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  43. Content type: Research

    Rising evidence indicate that oxytocin and IL-1β impact trigemino-nociceptive signaling. Current perspectives on migraine physiopathology emphasize a cytokine bias towards a pro-inflammatory status. The anti-n...

    Authors: Azize Boström, Dirk Scheele, Birgit Stoffel-Wagner, Frigga Hönig, Shafqat R. Chaudhry, Sajjad Muhammad, Rene Hurlemann, Joachim K. Krauss, Ilana S. Lendvai, Krishnan V. Chakravarthy and Thomas M. Kinfe

    Citation: Journal of Translational Medicine 2019 17:53

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  44. Content type: Research

    MET amplification is associated with acquired resistance to first-generation epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitors (TKIs) in treating non-small-cell lung cancer (NSCLC); however, t...

    Authors: Wenxian Wang, Hong Wang, Peihua Lu, Zongyang Yu, Chunwei Xu, Wu Zhuang and Zhengbo Song

    Citation: Journal of Translational Medicine 2019 17:52

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  45. Content type: Research

    Inflammation and demyelination are the main processes in multiple sclerosis. Nevertheless, to date, blood biomarkers of inflammation are lacking. TWEAK, a transmembrane protein that belongs to the TNF ligand f...

    Authors: Adil Maarouf, Delphine Stephan, Marie-Pierre Ranjeva, Jean-Philippe Ranjeva, Jean Pelletier, Bertrand Audoin, Michel Khrestchatisky and Sophie Desplat-Jégo

    Citation: Journal of Translational Medicine 2019 17:51

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  46. Content type: Research

    Recently, circular RNAs (circRNAs) have been reported to be microRNA sponges and play essential roles in cancer development. This study aimed to evaluate whether circulating circRNAs could be used as diagnosti...

    Authors: Xiao-Xia Liu, Yi-E Yang, Xiao Liu, Meng-Yu Zhang, Rui Li, Yun-Hong Yin and Yi-Qing Qu

    Citation: Journal of Translational Medicine 2019 17:50

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  47. Content type: Research

    Obesity is associated with impaired glucose tolerance which is a risk factor for cardiovascular risk. However, the oral glucose tolerance test (OGTT) is not usually performed in patients with normal fasting gl...

    Authors: Belén Pérez-Pevida, Jorge M. Núñez-Córdoba, Sonia Romero, Alexander Dimitri Miras, Patricia Ibañez, Neus Vila, María Ángeles Margall, Camilo Silva, Javier Salvador, Gema Frühbeck and Javier Escalada

    Citation: Journal of Translational Medicine 2019 17:48

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  48. Content type: Research

    Immunology research, particularly next generation sequencing (NGS) of the immune T-cell receptor β (TCRβ) repertoire, has advanced progression in several fields, including treatment of various cancers and auto...

    Authors: Shang-Gin Wu, Wenjing Pan, Hongna Liu, Miranda L. Byrne-Steele, Brittany Brown, Mollye Depinet, Xiaohong Hou, Jian Han and Song Li

    Citation: Journal of Translational Medicine 2019 17:47

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