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  1. Destruction of articular cartilage and bone is the main cause of joint dysfunction in rheumatoid arthritis (RA). Acid-sensing ion channel 1a (ASIC1a) is a key molecule that mediates the destruction of RA artic...

    Authors: Zhuoyan Zai, Yayun Xu, Xuewen Qian, Zihan Li, Ziyao Ou, Tao Zhang, Longfei Wang, Yian Ling, Xiaoqing Peng, Yihao Zhang and Feihu Chen
    Citation: Journal of Translational Medicine 2022 20:561
  2. The coronavirus disease 2019 (COVID-19) severely hindered the timely receipt of health care for patients with cancer, especially female patients. Depression and anxiety were more pronounced in female patients ...

    Authors: Yu Min, Zheran Liu, Rendong Huang, Ruidan Li, Jing Jin, Zhigong Wei, Ling He, Yiyan Pei, Ning Li, Yongllin Su, Xiaolin Hu and Xingchen Peng
    Citation: Journal of Translational Medicine 2022 20:560
  3. Cancer-associated fibroblasts (CAFs), one of the major components of the tumor stroma, contribute to an immunosuppressive tumor microenvironment (TME) through the induction and functional polarization of protu...

    Authors: Katayoon Pakravan, Majid Mossahebi-Mohammadi, Mohammad H. Ghazimoradi, William C. Cho, Majid Sadeghizadeh and Sadegh Babashah
    Citation: Journal of Translational Medicine 2022 20:559
  4. Clear cell renal cell cancer (ccRCC) is accompanied by T-cell infiltration. In this study, we sought to determine the difference in T-cell infiltration and the T-cell receptor (TCR) immune repertoire between c...

    Authors: Wei Zhang, Qian Zhang, Chao Zhu, Zhiyuan Shi, Chen Shao, Yujie Chen, Nan Wang, Yanxia Jiang, Qing Liang and Kejia Wang
    Citation: Journal of Translational Medicine 2022 20:558
  5. Lymph node metastasis (LNM) is one of the most important factors affecting the prognosis of breast cancer. The accurate evaluation of lymph node status is useful to predict the outcomes of patients and guide t...

    Authors: Zhi-Wei Guo, Qing Liu, Xu Yang, Geng-Xi Cai, Bo-Wei Han, Li-Min Huang, Chun-Xi Li, Zhi-Kun Liang, Xiang-Ming Zhai, Li Lin, Kun Li, Min Zhang, Tian-Cai Liu, Rui-lin Pan, Ying-Song Wu and Xue-Xi Yang
    Citation: Journal of Translational Medicine 2022 20:557
  6. Epithelial ovarian cancer is the most lethal gynaecological cancer worldwide. Chemotherapy resistance represents a significant clinical challenge and is the main reason for poor ovarian cancer prognosis. We id...

    Authors: Dilys Leung, Zoe K. Price, Noor A. Lokman, Wanqi Wang, Lizamarie Goonetilleke, Elif Kadife, Martin K. Oehler, Carmela Ricciardelli, George Kannourakis and Nuzhat Ahmed
    Citation: Journal of Translational Medicine 2022 20:556
  7. Solid tumors are stiffer than their surrounding normal tissues; however, their interior stiffness is not uniform. Under certain conditions, cancer cells can acquire stem-like phenotypes. However, it remains un...

    Authors: Jiayun Wei, Jia Yao, Chendong Yang, Yongcui Mao, Dan Zhu, Ye Xie, Pinyan Liu, Mengchao Yan, Longfei Ren, Yan Lin, Qiuxia Zheng and Xun Li
    Citation: Journal of Translational Medicine 2022 20:555
  8. Clear cell renal cell carcinoma (ccRCC), the most common urological malignancy, has an unfavorable prognosis and an unknown mechanism of progression. Through survival analyses screening of The Cancer Genome At...

    Authors: Wenliang Ma, Xin Li, Lei Yang, Jun Pan, Yi Chen, Yanwen Lu, Xiang Dong, Dongmei Li and Weidong Gan
    Citation: Journal of Translational Medicine 2022 20:554
  9. The objective of this study was to explore the clinical application of noninvasive chromosomal screening (NICS) for elective single-blastocyst transfer (eSBT) in frozen-thawed cycles.

    Authors: Rui Chen, Ni Tang, Hongzi Du, Yaxin Yao, Yangyun Zou, Jing Wang, Dunmei Zhao, Xueliang Zhou, Yang Luo, Lei Li and Yuling Mao
    Citation: Journal of Translational Medicine 2022 20:553
  10. Associations of drugs with diseases provide important information for expediting drug development. Due to the number of known drug-disease associations is still insufficient, and considering that inferring ass...

    Authors: Mei-Neng Wang, Xue-Jun Xie, Zhu-Hong You, De-Wu Ding and Leon Wong
    Citation: Journal of Translational Medicine 2022 20:552
  11. Chagas disease is a neglected tropical disease in Latin America and an imported emerging disease worldwide. Chronic Chagas disease cardiomyopathy (CCC) is the most prominent clinical form and can lead to heart...

    Authors: Gregório Guilherme Almeida, Inga Rimkute, Isabela Natália Pascoal Campos do Vale, Thomas Liechti, Priscilla Miranda Henriques, Ester Roffe, Fernanda Fortes de Araújo, Manoel Otávio da Costa Rocha, Silvana Maria Elói Santos, Olindo Assis Martins-Filho, Dragana Jankovic, Alan Sher, Andrea Teixeira-Carvalho, Mario Roederer and Lis Ribeiro do Valle Antonelli
    Citation: Journal of Translational Medicine 2022 20:551
  12. Pharmacogenomics (PGx) aims to utilize a patient’s genetic data to enable safer and more effective prescribing of medications. The Clinical Pharmacogenetics Implementation Consortium (CPIC) provides guidelines...

    Authors: Shefali S. Verma, Karl Keat, Binglan Li, Glenda Hoffecker, Marjorie Risman, Katrin Sangkuhl, Michelle Whirl-Carrillo, Scott Dudek, Anurag Verma, Teri E. Klein, Marylyn D. Ritchie and Sony Tuteja
    Citation: Journal of Translational Medicine 2022 20:550
  13. The COVID-19 pandemic has become a huge threat to human health, infecting millions of people worldwide and causing enormous economic losses. Many novel small molecule drugs have been developed to treat patient...

    Authors: Keyu Kong, Yongyun Chang, Hua Qiao, Chen Zhao, Xuzhuo Chen, Kewei Rong, Pu Zhang, Minghao Jin, Jingwei Zhang, Huiwu Li and Zanjing Zhai
    Citation: Journal of Translational Medicine 2022 20:549
  14. Acute lung injury (ALI) occurs in 23% unilateral. Models of unilateral ALI were developed and used previously without clearly demonstrating the strictly unilateral nature and severity of lung injury by the key...

    Authors: Johannes Geilen, Matthias Kainz, Bernhard Zapletal, Silvana Geleff, Wilfried Wisser, Barbara Bohle, Thomas Schweiger, Marcus J. Schultz and Edda Tschernko
    Citation: Journal of Translational Medicine 2022 20:548
  15. Accumulating evidence supports the implication of circular RNAs (circRNAs) in systemic lupus erythematosus (SLE). However, little is known about the detailed mechanisms and roles of circRNAs in the pathogenesi...

    Authors: Xingwang Zhao, Rui Dong, Zhongwei Tang, Juan Wang, Chunyou Wang, Zhiqiang Song, Bing Ni, Longlong Zhang, Xiaochong He and Yi You
    Citation: Journal of Translational Medicine 2022 20:547
  16. Sepsis-associated encephalopathy (SAE) is one of the most common types of sepsis-related organ dysfunction without overt central nervous system (CNS) infection. It is associated with higher mortality, low qual...

    Authors: John Sieh Dumbuya, Siqi Li, Lili Liang, Yanchen Chen, Jiang Du and Qiyi Zeng
    Citation: Journal of Translational Medicine 2022 20:546
  17. This study aimed to analyze the clinical outcomes of blastocyst which undergo the preimplantation genetic testing (PGT) transplantation from frozen-thawed D5 and D6. In addition, the effect of blastocyst grade...

    Authors: Guanling Yu, Shuiying Ma, Hui Liu, Yujin Liu, Haozhen Zhang, Wenjia Zhang and Keliang Wu
    Citation: Journal of Translational Medicine 2022 20:545
  18. Arteriovenous fistula (AVF) maturation is a process involving remodeling of venous arm of the AVFs. It is a challenge to balance adaptive AVF remodeling and neointima formation. In this study we temporally con...

    Authors: Qunying Guo, Guang Chen, Hunter Cheng, Ying Qing, Luan Truong, Quan Ma, Yun Wang and Jizhong Cheng
    Citation: Journal of Translational Medicine 2022 20:543
  19. Despite the recent progress in the treatment and outcome of Non Small Cell Lung Cancer (NSCLC), immunotherapy has still significant limitations reporting a significant proportion of patients not benefiting fro...

    Authors: Carminia Maria Della Corte, Vincenza Ciaramella, Kavya Ramkumar, Giovanni Vicidomini, Alfonso Fiorelli, Valerio Nardone, Salvatore Cappabianca, Immacolata Cozzolino, Federica Zito Marino, Gaetano Di Guida, Qi Wang, Robert Cardnell, Carl Michael Gay, Davide Ciardiello, Erika Martinelli, Teresa Troiani…
    Citation: Journal of Translational Medicine 2022 20:541
  20. In recent years, the biological role of changes in physical factors in carcinogenesis and progression has attracted increasing attention. Matrix stiffness, also known as ECM stress, is a critical physical fact...

    Authors: Boer Deng, Ziyi Zhao, Weimin Kong, Chao Han, Xiaochang Shen and Chunxiao Zhou
    Citation: Journal of Translational Medicine 2022 20:540
  21. Posttranslational protein modifications regulate essential cellular processes, including the immune cell activation. Despite known age-related alterations of the phenotype, composition and cytokine profiles of...

    Authors: Georgiana Toma, Eliza Karapetian, Chiara Massa, Dagmar Quandt and Barbara Seliger
    Citation: Journal of Translational Medicine 2022 20:539
  22. Extracorporeal blood purification therapies targeting removal of the downstream products of the inflammatory cascade in sepsis have failed to improve mortality. As an upstream process of the inflammatory casca...

    Authors: Lei Zhou, Dong Zhang, Ling Kong, Xiaodong Xu and Dehua Gong
    Citation: Journal of Translational Medicine 2022 20:538
  23. Multiple myeloma (MM) is a malignancy of plasma cells that remains incurable. Toll-like receptor 4 (TLR4) acts as a stress-responsive signal, protecting mitochondria during proteasome inhibitor (PI) exposure, ...

    Authors: Lina Quan, Chuiming Jia, Yiwei Guo, Yao Chen, Xinya Wang, Qiuting Xu and Yu Zhang
    Citation: Journal of Translational Medicine 2022 20:537
  24. Chromosomal aneuploidy is the most common birth defect. However, the developmental mechanism and gene expression profile of fetuses with chromosomal aneuploidy are relatively unknown, and the maternal immune c...

    Authors: Min Zhang, Kun Li, Shoufang Qu, Zhiwei Guo, Yuanli Wang, Xu Yang, Junhua Zhou, Guojun Ouyang, Rongtao Weng, Fenxia Li, Yingsong Wu and Xuexi Yang
    Citation: Journal of Translational Medicine 2022 20:536
  25. Abnormal gene expression level or expression of genes containing deleterious mutations are two of the main determinants which lead to genetic disease. To obtain a therapeutic effect and thus to cure genetic di...

    Authors: Hsing-Chuan Tsai, Violena Pietrobon, Maoyu Peng, Suning Wang, Lihong Zhao, Francesco M. Marincola and Qi Cai
    Citation: Journal of Translational Medicine 2022 20:535
  26. Gene editing has great potential in treating diseases caused by well-characterized molecular alterations. The introduction of clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associate...

    Authors: Ajaz A. Bhat, Sabah Nisar, Soumi Mukherjee, Nirmalya Saha, Nageswari Yarravarapu, Saife N. Lone, Tariq Masoodi, Ravi Chauhan, Selma Maacha, Puneet Bagga, Punita Dhawan, Ammira Al-Shabeeb Akil, Wael El-Rifai, Shahab Uddin, Ravinder Reddy, Mayank Singh…
    Citation: Journal of Translational Medicine 2022 20:534
  27. Circular ribonucleic acids (circRNAs) are a class of long non-coding RNA that were once regarded as non-functional transcription byproducts. However, recent studies suggested that circRNAs may exhibit importan...

    Authors: Ryan Wong, Yiwen Zhang, Hailin Zhao and Daqing Ma
    Citation: Journal of Translational Medicine 2022 20:533
  28. The crosstalk of purine biosynthesis and metabolism exists to balance the cell energy production, proliferation, survival and cytoplasmic environment stability, but disorganized mechanics of with respect to de...

    Authors: Ge Wang, Rongjun Zou, Libao Liu, Zongtao Wang, Zengxiao Zou, Songtao Tan, Wenliu Xu and Xiaoping Fan
    Citation: Journal of Translational Medicine 2022 20:532
  29. Non-small cell lung cancer (NSCLC) is the most widely distributed tumor in the world, and its immunotherapy is not practical. Neutrophil is one of a tumor’s most abundant immune cell groups. This research aime...

    Authors: Jianyu Pang, Qian Yu, Yongzhi Chen, Hongjun Yuan, Miaomiao Sheng and Wenru Tang
    Citation: Journal of Translational Medicine 2022 20:531
  30. Liver cancer is the fifth leading cause of cancer death worldwide, but early diagnosis and treatment of liver cancer remains a clinical challenge. How to screen and diagnose liver cancer early and prolong the ...

    Authors: Lihua Wang, Zheng Zhu, Qi Liang, Yecheng Tao, Gaowei Jin, Yaoyao Zhong, Jichen Dai, Ruixia Dai, Zhixiang Wang, Junbo Chen, Lingjie Zhou, Shouyu Ke, Bin Zheng, Linhua Lan, Xiaokun Lin and Tongke Chen
    Citation: Journal of Translational Medicine 2022 20:530
  31. Non-alcoholic fatty liver disease (NAFLD) is a metabolic disorder with abnormal lipid metabolism. The present study was to identify regulatory genes related to lipid droplets (LDs) abnormal accumulation in NAFLD.

    Authors: Zhiyong He, Yangyang Bin, Guangshun Chen, Qiang Li, Wenling Fan, Yongqiang Ma, Junfang Yi, Xiaohua Luo, Zhi Tan and Jiequn Li
    Citation: Journal of Translational Medicine 2022 20:529
  32. MICAL1 is involved in the malignant processes of several types of cancer; however, the role of MICAL1 in pancreatic cancer (PC) has not been well-characterized. This study aimed to investigate the expression a...

    Authors: Kun Cai, Lu Deng, Dijie Zheng, Lin Li, Zhiwei He and Chao Yu
    Citation: Journal of Translational Medicine 2022 20:528
  33. The role of the inflammatory milieu in prostate cancer progression is not well understood. Differences in inflammatory signaling between localized and metastatic disease may point to opportunities for early in...

    Authors: Ida Deichaite, Timothy J. Sears, Leisa Sutton, Daniel Rebibo, Kylie Morgan, Tyler Nelson, Brent Rose, Pablo Tamayo, Napoleone Ferrara, Fotis Asimakopoulos and Hannah Carter
    Citation: Journal of Translational Medicine 2022 20:527
  34. COVID-19 infections could be complicated by acute respiratory distress syndrome (ARDS), increasing mortality risk. We sought to assess the methylome of peripheral blood mononuclear cells in COVID-19 with ARDS.

    Authors: Martina Bradic, Sarah Taleb, Binitha Thomas, Omar Chidiac, Amal Robay, Nessiya Hassan, Joel Malek, Ali Ait Hssain and Charbel Abi Khalil
    Citation: Journal of Translational Medicine 2022 20:526
  35. Non-small cell lung cancer (NSCLC) is the most common lung cancer with high mortality across the world, but it is challenging to develop an effective therapy for NSCLC. Celastrol is a natural bioactive compoun...

    Authors: Zhucheng Zhao, Yanmao Wang, Yuyan Gong, Xian Wang, Luyao Zhang, Haiyang Zhao, Jifa Li, Jiandong Zhu, Xiaoying Huang, Chengguang Zhao, Lehe Yang and Liangxing Wang
    Citation: Journal of Translational Medicine 2022 20:525
  36. This paper intends to propose a method of using TransResSEUnet2.5D network for accurate automatic segmentation of the Gross Target Volume (GTV) in Radiotherapy for lung cancer.

    Authors: Hui Xie, Zijie Chen, Jincheng Deng, Jianfang Zhang, Hanping Duan and Qing Li
    Citation: Journal of Translational Medicine 2022 20:524
  37. Pulmonary fibrosis is a chronic progressive fibrotic interstitial lung disease characterized by excessive extracellular matrix (ECM) deposition caused by activated fibroblasts. Increasing evidence shows that m...

    Authors: Demin Cheng, Ziwei Li, Yue Wang, Haojie Xiong, Wenqing Sun, Siyun Zhou, Yi Liu and Chunhui Ni
    Citation: Journal of Translational Medicine 2022 20:523
  38. Cardiac mesenchymal stromal cells (C-MSC) were recently shown to differentiate into adipocytes and myofibroblasts to promote the aberrant remodeling of cardiac tissue that characterizes arrhythmogenic cardiomy...

    Authors: Angela S. Maione, Pawan Faris, Lara Iengo, Valentina Catto, Luca Bisonni, Francesco Lodola, Sharon Negri, Michela Casella, Anna Guarino, Gianluca Polvani, Marina Cerrone, Claudio Tondo, Giulio Pompilio, Elena Sommariva and Francesco Moccia
    Citation: Journal of Translational Medicine 2022 20:522
  39. We reported that PARP-1 regulates genes whose products are crucial for asthma, in part, by controlling STAT6 integrity speculatively through a calpain-dependent mechanism. We wished to decipher the PARP-1/STAT...

    Authors: Jeffrey Wang, Mohamed A. Ghonim, Salome V. Ibba, Hanh H. Luu, Yucel Aydin, Peter A. Greer and A. Hamid Boulares
    Citation: Journal of Translational Medicine 2022 20:521
  40. The tumour microenvironment and cirrhotic liver are excellent sources of cancer-associated fibroblasts (CAFs), which participate in carcinogenesis. Thus, it is important to clarify the crosstalk between CAFs a...

    Authors: Jungang Zhao, Rizhao Li, Jiacheng Li, Ziyan Chen, Zixia Lin, Baofu Zhang, Liming Deng, Gang Chen and Yi Wang
    Citation: Journal of Translational Medicine 2022 20:520
  41. Chronic graft-versus-host disease (GVHD) is a major cause of late morbidity and non-relapse mortality in recipients of allogeneic hematopoietic cell transplantation (HCT). Its biology, however, remains poorly ...

    Authors: Alain Mina, Lauren Curtis, Kamille West, Yu Ying Yau, Edward W. Cowen, Frances Hakim and Steven Z. Pavletic
    Citation: Journal of Translational Medicine 2022 20:519
  42. Identifying patterns of variation in obesity indices and other cardiometabolic risk factors before the diagnosis of type 2 diabetes could provide insight into the critical period when drastic changes occurred ...

    Authors: Fatemeh Koohi, Nooshin Ahmadi, Fereidoun Azizi, Davood Khalili and Majid Valizadeh
    Citation: Journal of Translational Medicine 2022 20:518
  43. Facioscapulohumeral muscular dystrophy (FSHD) is an autosomal dominant muscular disorder characterized by asymmetric muscle wasting and weakness. FSHD can be subdivided into two types: FSHD1, caused by contrac...

    Authors: Yosuke Hiramuki, Yuriko Kure, Yoshihiko Saito, Megumu Ogawa, Keiko Ishikawa, Madoka Mori-Yoshimura, Yasushi Oya, Yuji Takahashi, Dae-Seong Kim, Noriko Arai, Chiaki Mori, Tsuyoshi Matsumura, Tadanori Hamano, Kenichiro Nakamura, Koji Ikezoe, Shinichiro Hayashi…
    Citation: Journal of Translational Medicine 2022 20:517
  44. Cellular compositions of solid tumor microenvironments are heterogeneous, varying across patients and tumor types. High-resolution profiling of the tumor microenvironment cell composition is crucial to underst...

    Authors: Ze Zhang, John K. Wiencke, Karl T. Kelsey, Devin C. Koestler, Brock C. Christensen and Lucas A. Salas
    Citation: Journal of Translational Medicine 2022 20:516
  45. Osteoarthritis (OA) is a chronic degenerative joint disease characterized by the destruction of the articular cartilage, sclerosis of the subchondral bone, and joint dysfunction. Its pathogenesis is attributed...

    Authors: Jianghong Huang, Qisong Liu, Jiang Xia, Xi Chen, Jianyi Xiong, Lei Yang and Yujie Liang
    Citation: Journal of Translational Medicine 2022 20:515
  46. Clinical CAR T-cell therapy using integrating vector systems represents a promising approach for the treatment of hematological malignancies. Lentiviral and γ-retroviral vectors are the most commonly used vect...

    Authors: Lipei Shao, Rongye Shi, Yingdong Zhao, Hui Liu, Alexander Lu, Jinxia Ma, Yihua Cai, Tatyana Fuksenko, Alejandra Pelayo, Nirali N. Shah, James N. Kochenderfer, Scott M. Norberg, Christian Hinrichs, Steven L. Highfill, Robert P Somerville, Sandhya R. Panch…
    Citation: Journal of Translational Medicine 2022 20:514
  47. Despite a recent increase in the number of RNA-seq datasets investigating heart failure (HF), accessibility and usability remain critical issues for medical researchers. We address the need for an intuitive an...

    Authors: Thiago Britto-Borges, Annekathrin Ludt, Etienne Boileau, Enio Gjerga, Federico Marini and Christoph Dieterich
    Citation: Journal of Translational Medicine 2022 20:513
  48. The metastatic mechanisms of axillary lymph nodes (ALNs) in triple-negative breast cancer (TNBC) remain unclear. We aimed to identify the potential circRNA regulatory network in ALN metastasis.

    Authors: Jiayue Luo, Dong Cao, Chuwen Hu, Zhen Liang, Yuanping Zhang and Jianguo Lai
    Citation: Journal of Translational Medicine 2022 20:508

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