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Journal of Translational Medicine


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  1. Content type: Research

    Radiotherapy constitutes a standard arm of therapy in the multimodal treatment of patients with glioblastoma (GBM). Ironically, studies have recently revealed that radiation can augment malignant progression, ...

    Authors: Xin Zhang, Xuehai Wang, Ran Xu, Jianxiong Ji, Yangyang Xu, Mingzhi Han, Yuzhen Wei, Bin Huang, Anjing Chen, Qing Zhang, Wenjie Li, Jian Wang, Xingang Li and Chen Qiu

    Citation: Journal of Translational Medicine 2018 16:79

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  2. Content type: Research

    Acute lung injury caused by renal ischemia–reperfusion is one of the leading causes of acute kidney injury-related death. Dexmedetomidine, an α2-adrenergic agonist sedative, has been found to have protective effe...

    Authors: Juanjuan Li, Qian Chen, Xinhai He, Azeem Alam, Jiaolin Ning, Bin Yi, Kaizhi Lu and Jianteng Gu

    Citation: Journal of Translational Medicine 2018 16:78

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  3. Content type: Research

    Squamous cell carcinoma (SCC) of the conjunctiva is a common cancer in Africa mainly associated with solar ultraviolet (UV) exposure and human immunodeficiency virus (HIV) infection. We analyzed the role of HI...

    Authors: Noemy Starita, Luigi Buonaguro, Franco M. Buonaguro and Maria Lina Tornesello

    Citation: Journal of Translational Medicine 2018 16:77

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  4. Content type: Research

    Articular cartilage degeneration plays a key role in the pathogenesis of osteoarthritis (OA). Bushenhuoxue formula (BSHXF) has been widely used in the treatment of OA in clinics. However, the molecular mechani...

    Authors: Ping-er Wang, Lei Zhang, Jun Ying, Xing Jin, Cheng Luo, Shibing Xu, Rui Dong, Luwei Xiao, Peijian Tong and Hongting Jin

    Citation: Journal of Translational Medicine 2018 16:72

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  5. Content type: Research

    Ulcerative colitis (UC) is a type of inflammatory bowel disease (IBD) characterized by chronic inflammation of colon. It is commonly believed that the imbalance of immune system and overwhelming production of ...

    Authors: Baoren Zhang, Yi Liu, Xu Lan, Xiaoxi Xu, Xiaoning Zhang, Xiang Li, Yiming Zhao, Guang Li, Caigan Du, Shanzheng Lu and Hao Wang

    Citation: Journal of Translational Medicine 2018 16:71

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  6. Content type: Research

    This study addresses whether the association of adiponectin gene (ADIPOQ) variants with idiopathic recurrent pregnancy loss (RPL) is influenced by obesity.

    Authors: Maryam Dendana, Wael Bahia, Ramzi R. Finan, Mariam Al-Mutawa and Wassim Y. Almawi

    Citation: Journal of Translational Medicine 2018 16:76

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  7. Content type: Review

    Immunotherapy has matured into standard treatment for several cancers, but much remains to be done to extend the reach of its effectiveness particularly to cancers that are resistant within each indication. Th...

    Authors: Laura Soldati, Laura Di Renzo, Emilio Jirillo, Paolo A. Ascierto, Francesco M. Marincola and Antonino De Lorenzo

    Citation: Journal of Translational Medicine 2018 16:75

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  8. Content type: Research

    The aim of this study was to investigate the mechanisms of OX40L in regulating helper T (Th) cells differentiation through phosphoinositide 3-kinase (PI3K)/AKT and p38 mitogen-activated protein kinase signalin...

    Authors: Li Huang, Meijuan Wang, Yongdong Yan, Wenjing Gu, Xinxing Zhang, Jiahong Tan, Huiming Sun, Wei Ji and Zhengrong Chen

    Citation: Journal of Translational Medicine 2018 16:74

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  9. Content type: Research

    Controversy exists in previous studies on macrophage M1/M2 polarization in chronic obstructive pulmonary disease (COPD). We hypothesized that formyl peptide receptor (FPR), a marker of efferocytosis and mediat...

    Authors: Yung-Che Chen, Meng-Chih Lin, Chih-Hung Lee, Shih-Feng Liu, Chin-Chou Wang, Wen-Feng Fang, Tung-Ying Chao, Chao-Chien Wu, Yu-Feng Wei, Huang-Chih Chang, Chia-Cheng Tsen and Hung-Chen Chen

    Citation: Journal of Translational Medicine 2018 16:69

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  10. Content type: Research

    Periodontitis is an infectious disease that manifests as alveolar bone loss surrounding the roots of teeth. Diabetes aggravates periodontitis-induced alveolar bone loss via suppression of bone formation. Inter...

    Authors: Ji-Hye Kim, Ae Ri Kim, Yun Hui Choi, Aeryun Kim, Yongsung Sohn, Gye-Hyeong Woo, Jeong-Heon Cha, Eun-Jung Bak and Yun-Jung Yoo

    Citation: Journal of Translational Medicine 2018 16:70

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  11. Content type: Research

    Periampullary adenocarcinomas, including pancreatic cancer, are a heterogeneous group of tumors with poor prognosis, where classification into intestinal type (I-type) or pancreatobiliary type (PB-type) is a r...

    Authors: Margareta Heby, Sebastian Lundgren, Björn Nodin, Jacob Elebro, Jakob Eberhard and Karin Jirström

    Citation: Journal of Translational Medicine 2018 16:66

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  12. Content type: Research

    Bone marrow stromal cells (BMSCs) have classically been cultured in media supplemented with fetal bovine serum (FBS). As an alternative to FBS, pooled solvent detergent apheresis platelets, HPGF-C18, was evalu...

    Authors: Jiaqiang Ren, Dawn Ward, Steven Chen, Katherine Tran, Ping Jin, Marianna Sabatino, Pamela G. Robey and David F. Stroncek

    Citation: Journal of Translational Medicine 2018 16:65

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  13. Content type: Research

    Fibrinogen is a central player in the blood coagulation cascade and one of the most abundant plasma proteins. This glycoprotein also triggers important events (e.g., cell spreading, the respiratory burst and d...

    Authors: Tiziana Alberio, Greta Forlani, Marta Lualdi, Giovanna Tosi, Roberto S. Accolla and Mauro Fasano

    Citation: Journal of Translational Medicine 2018 16:64

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  14. Content type: Research

    Human neutrophil antigen 3 (HNA-3) is encoded by the SLC44A2 gene. Antibodies against HNAs can cause severe, often fatal, transfusion reactions, known as transfusion-related acute lung injury, and neonatal neu...

    Authors: Guo-Jin Ou, Pin-Can Su, Hao Yu, Xin Ji, Fan Liu, Sheng-Lan Wang, Yu-Jie Kong, Ling Li, Jue Wang, Zhong Liu and Willy Albert Flegel

    Citation: Journal of Translational Medicine 2018 16:67

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  15. Content type: Research

    MicroRNAs are of special interest in cancer research and hold significant promise as diagnostic and prognostic biomarkers for malignant disease. MiR-362-5p have been found to exert both oncogenic and tumor sup...

    Authors: Qiu-Ling Ma, Jing-Han Wang, Min Yang, Huan-ping Wang and Jie Jin

    Citation: Journal of Translational Medicine 2018 16:68

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  16. Content type: Research

    Age-related macular degeneration (AMD) is a leading cause of blindness among the elderly characterized by retinal pigment epithelium (RPE) degeneration with accumulation of abnormal intracellular deposits (lip...

    Authors: George Inana, Christopher Murat, Weijun An, Xiang Yao, Ian R. Harris and Jing Cao

    Citation: Journal of Translational Medicine 2018 16:63

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  17. Content type: Research

    Shigellosis persists as a public health problem worldwide causing ~ 165,000 deaths every year, of which ~ 55,000 are in children less than 5 years of age. No vaccine against shigellosis is currently licensed. ...

    Authors: Franklin R. Toapanta, Paula J. Bernal, Karen L. Kotloff, Myron M. Levine and Marcelo B. Sztein

    Citation: Journal of Translational Medicine 2018 16:61

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  18. Content type: Research

    Diagnosis of de novo immune hepatitis (dnIH) after liver transplantation relies on biopsy findings, with an abundance of plasma cells (PCs) in the inflammatory infiltrates a hallmark of the disease. Very littl...

    Authors: Elena Aguado-Domínguez, Lourdes Gómez, José Manuel Sousa, Miguel Ángel Gómez-Bravo, Antonio Núñez-Roldán and Isabel Aguilera

    Citation: Journal of Translational Medicine 2018 16:62

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  19. Content type: Research

    MicroRNAs (miRNAs) are small RNAs regulating gene expression post-transcriptionally. While acquired changes of miRNA and mRNA profiles in cancer have been extensively studied, little is known about expression ...

    Authors: Masood Abu-Halima, Mustafa Kahraman, Dominic Henn, Tanja Rädle-Hurst, Andreas Keller, Hashim Abdul-Khaliq and Eckart Meese

    Citation: Journal of Translational Medicine 2018 16:60

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  20. Content type: Research

    Th17 cells and its effective cytokine IL-17A play an important role in the pathogenesis of abnormal immune responses in psoriasis. Notch1 signaling has been implicated in Th17 cell differentiation and function...

    Authors: Lei Ma, Haibo Xue, Ruiqun Qi, Yanqin Wang and Libing Yuan

    Citation: Journal of Translational Medicine 2018 16:59

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  21. Content type: Research

    Medical therapeutic options remain quite limited for uterine fibroids treatment. Statins, competitive inhibitors of 3-hydroxy-3-methylglutaryl-coenzyme A reductase, have anti-tumoral effects on multiple cancer...

    Authors: Zhaojun Shen, Saisai Li, Bo Sheng, Qi Shen, Lu-Zhe Sun, Haiyan Zhu and Xueqiong Zhu

    Citation: Journal of Translational Medicine 2018 16:53

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  22. Content type: Research

    There is a preponderance of evidence implicating diabetes with increased coronary artery disease (CAD) and calcification (CAC) in human patients with metabolic syndrome (MetS), but the effect of diabetes on CA...

    Authors: Jill K. Badin, Ayeeshik Kole, Benjamin Stivers, Victor Progar, Anisha Pareddy, Mouhamad Alloosh and Michael Sturek

    Citation: Journal of Translational Medicine 2018 16:58

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  23. Content type: Research

    Multiple sclerosis (MS) is a progressively debilitating neurological condition in which the immune system abnormally erodes the myelin sheath insulating the nerves. Mesenchymal stem cells (MSC) have been used ...

    Authors: Neil H. Riordan, Isabela Morales, Giselle Fernández, Nicole Allen, Neal E. Fearnot, Michael E. Leckrone, Dedra Jones Markovich, Darla Mansfield, Dorita Avila, Amit N. Patel, Santosh Kesari and Jorge Paz Rodriguez

    Citation: Journal of Translational Medicine 2018 16:57

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  24. Content type: Research

    Recently, the concepts of progression due to pre-existing lesions (PPL) and progression due to new metastasis (PNM) have been proposed to differentiate the progression types of treatment-resistant cancers. Pre...

    Authors: Shinichiro Kashiwagi, Gen Tsujio, Yuka Asano, Wataru Goto, Koji Takada, Katsuyuki Takahashi, Tamami Morisaki, Hisakazu Fujita, Tsutomu Takashima, Shuhei Tomita, Masahiko Ohsawa, Kosei Hirakawa and Masaichi Ohira

    Citation: Journal of Translational Medicine 2018 16:54

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