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  1. Extracorporeal membrane oxygenation (ECMO) is increasingly used in intensive care units and can modify drug pharmacokinetics and lead to under-exposure associated with treatment failure. Ceftolozane/tazobactam...

    Authors: Camille Mané, Clément Delmas, Jean Porterie, Géraldine Jourdan, Patrick Verwaerde, Bertrand Marcheix, Didier Concordet, Bernard Georges, Stéphanie Ruiz and Peggy Gandia

    Citation: Journal of Translational Medicine 2020 18:213

    Content type: Research

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  2. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Yu Gu, Fei Huang, Yanling Wang, Chaojin Chen, Shan Wu, Shaoli Zhou, Ziqing Hei and Dongdong Yuan

    Citation: Journal of Translational Medicine 2020 18:212

    Content type: Correction

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    The original article was published in Journal of Translational Medicine 2018 16:117

  3. Lipid abnormality and obesity have been proposed to be associated with lumbar disc degeneration, but little is known about the effect of ‘lipid healthy but obese’ (LH-O) and ‘lipid abnormal but not obese’ (LA-...

    Authors: Sheng Shi, Zhi Zhou, Jun-Jun Liao, Yue-Hua Yang, Jun-Song Wu, Shuang Zheng and Shi-Sheng He

    Citation: Journal of Translational Medicine 2020 18:211

    Content type: Research

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  4. The etiology of congenital scoliosis (CS) is complex and uncertain. Abnormal DNA methylation affects the growth and development of spinal development. In this study, we investigated the role of DNA methylation...

    Authors: Yuantao Wu, Hongqi Zhang, Mingxing Tang, Chaofeng Guo, Ang Deng, Jiong Li, Yunjia Wang, Lige Xiao and Guanteng Yang

    Citation: Journal of Translational Medicine 2020 18:210

    Content type: Research

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  5. As a nucleolar protein associated with ribosome biogenesis, pescadillo homolog 1 (PES1) has been reported to participate in the development of many cancers. However, its role in prostate cancer is not clearly ...

    Authors: Zhenming Jiang, Yuxi Zhang, Xi Chen, Yan Wang, Pingeng Wu, Chengzhang Wu and Dong Chen

    Citation: Journal of Translational Medicine 2020 18:209

    Content type: Research

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  6. Patients with metastatic uveal melanoma (MUM) in the liver usually die within 1 year. The development of new treatments for MUM has been limited by the lack of diverse MUM cell lines and appropriate animal mod...

    Authors: Takahito Sugase, Bao Q. Lam, Meggie Danielson, Mizue Terai, Andrew E. Aplin, J. Silvio Gutkind and Takami Sato

    Citation: Journal of Translational Medicine 2020 18:208

    Content type: Research

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  7. Most tumors develop abnormal fibrotic regions consisting of fibroblasts, immune cells, and a dense extracellular matrix (ECM) immersed in a viscous interstitial fluid, and an abundant fibrotic tumor microenvir...

    Authors: Anette Hauge and Einar K. Rofstad

    Citation: Journal of Translational Medicine 2020 18:207

    Content type: Review

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  8. Patients with critical illness due to infection with the 2019 coronavirus disease (COVID-19) show rapid disease progression to acute respiratory failure. The study aimed to screen the most useful predictive fa...

    Authors: Jingyuan Liu, Yao Liu, Pan Xiang, Lin Pu, Haofeng Xiong, Chuansheng Li, Ming Zhang, Jianbo Tan, Yanli Xu, Rui Song, Meihua Song, Lin Wang, Wei Zhang, Bing Han, Li Yang, Xiaojing Wang…

    Citation: Journal of Translational Medicine 2020 18:206

    Content type: Research

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  9. The COVID-19 pandemic has become the leading societal concern. The pandemic has shown that the public health concern is not only a medical problem, but also affects society as a whole; so, it has also become t...

    Authors: Negar Moradian, Hans D. Ochs, Constantine Sedikies, Michael R. Hamblin, Carlos A. Camargo Jr., J. Alfredo Martinez, Jacob D. Biamonte, Mohammad Abdollahi, Pedro J. Torres, Juan J. Nieto, Shuji Ogino, John F. Seymour, Ajith Abraham, Valentina Cauda, Sudhir Gupta, Seeram Ramakrishna…

    Citation: Journal of Translational Medicine 2020 18:205

    Content type: Review

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  10. The persistence of HIV-1 in reservoir cells is one of the major obstacles to eradicating the virus in infected individuals receiving combination antiretroviral therapy (ART). HIV-1 persists in infected cells a...

    Authors: Chiara Orlandi, Benedetta Canovari, Federica Bozzano, Francesco Marras, Zeno Pasquini, Francesco Barchiesi, Andrea De Maria, Mauro Magnani and Anna Casabianca

    Citation: Journal of Translational Medicine 2020 18:204

    Content type: Research

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  11. In late 2019, a novel coronavirus (SARS-CoV-2) emerged in Wuhan, capital city of Hubei province in China. Cases of SARS-CoV-2 infection quickly grew by several thousand per day. Less than 100 days later, the W...

    Authors: Christopher J. Rogers, Robert J. Harman, Bruce A. Bunnell, Martin A. Schreiber, Charlie Xiang, Fu-Sheng Wang, Antonio F. Santidrian and Boris R. Minev

    Citation: Journal of Translational Medicine 2020 18:203

    Content type: Review

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  12. Extracorporeal circulation during major cardiac surgery triggers a systemic inflammatory response affecting the clinical course and outcome. Recently, extracellular vesicle (EV) research has shed light onto a ...

    Authors: Lukas Wisgrill, Christian Lamm, Lena Hell, Johannes Thaler, Angelika Berger, Rene Weiss, Viktoria Weber, Harald Rinoesl, Michael J. Hiesmayr, Andreas Spittler and Martin H. Bernardi

    Citation: Journal of Translational Medicine 2020 18:202

    Content type: Research

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  13. Increasing evidences have found that the clinical importance of the interaction between hypoxia and immune status in gastric cancer microenvironment. However, reliable prognostic signatures based on combinatio...

    Authors: Yifan Liu, Jianhua Wu, Weiwei Huang, Shaowen Weng, Baochun Wang, Yiming Chen and Hao Wang

    Citation: Journal of Translational Medicine 2020 18:201

    Content type: Research

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  14. Glioblastoma stem-like cells (GSCs) are hypothesized to contribute to self-renewal and therapeutic resistance in glioblastoma multiforme (GBM) tumors. Constituting only a small percentage of cancer cells, GSCs...

    Authors: Xu Wang, Wenjuan Zhou, Xian Li, Jun Ren, Guangyu Ji, Jingyi Du, Wenyu Tian, Qian Liu and Aijun Hao

    Citation: Journal of Translational Medicine 2020 18:200

    Content type: Research

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  15. Accurate etiology diagnosis is crucial for central nervous system infections (CNS infections). The diagnostic value of metagenomic next-generation sequencing (mNGS), an emerging powerful platform, remains to b...

    Authors: Yi Zhang, Peng Cui, Hao-Cheng Zhang, Hong-Long Wu, Ming-Zhi Ye, Yi-Min Zhu, Jing-Wen Ai and Wen-Hong Zhang

    Citation: Journal of Translational Medicine 2020 18:199

    Content type: Research

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  16. Chronic Fatigue Syndrome/Myalgic Encephalomyelitis/Systemic Exertion Intolerance Disease (CFS/ME/SEID) is a complex illness that has an unknown aetiology. It has been proposed that metabolomics may contribute ...

    Authors: Teilah Kathryn Huth, Natalie Eaton-Fitch, Donald Staines and Sonya Marshall-Gradisnik

    Citation: Journal of Translational Medicine 2020 18:198

    Content type: Review

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  17. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Saravanan Subramanian, Pradeep K. Pallati, Poonam Sharma, Devendra K. Agrawal and Kalyana C. Nandipati

    Citation: Journal of Translational Medicine 2020 18:197

    Content type: Retraction Note

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    The original article was published in Journal of Translational Medicine 2017 15:85

  18. We present the rationale for a novel allo-priming approach to serve the elderly as a universal anti-virus vaccine, as well serving to remodel the aging immune system in order to reverse immunosenescence and in...

    Authors: Michael Har-Noy and Reuven Or

    Citation: Journal of Translational Medicine 2020 18:196

    Content type: Review

    Published on:

  19. Green tea drinking has been proven to lower lipid and exert cardiovascular protection, while the potential mechanism has not been fully determined. This study was to investigate whether the beneficial impact o...

    Authors: Chuan-Jue Cui, Jing-Lu Jin, Lin-Na Guo, Jing Sun, Na-Qiong Wu, Yuan-Lin Guo, Geng Liu, Qian Dong and Jian-Jun Li

    Citation: Journal of Translational Medicine 2020 18:195

    Content type: Research

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  20. The association between blood pressure change and kidney damage in patients with abnormal blood glucose remains unclear. The current study aimed to identify systolic blood pressure (SBP) trajectories among the...

    Authors: Zi-Jun Sun, Jin-Wei Wang, Dong-Yuan Chang, Shuo-Hua Chen, Hui-Fen Zhang, Shou-Ling Wu, Kevin He, Lu-Xia Zhang, Min Chen and Ming-Hui Zhao

    Citation: Journal of Translational Medicine 2020 18:194

    Content type: Research

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  21. Glutamate, a key intermediate in myocardial metabolism, may enhance myocardial recovery after ischemia and possibly reduce the incidence and severity of postoperative heart failure in coronary artery bypass su...

    Authors: Huiqi Jiang, Jonas Holm, Mårten Vidlund, Farkas Vanky, Örjan Friberg, Yanqi Yang and Rolf Svedjeholm

    Citation: Journal of Translational Medicine 2020 18:193

    Content type: Research

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  22. Most mutations in melanoma affect one critical amino acid on BRAF gene, resulting in the V600E substitution. Patient management is often based on the use of specific inhibitors targeting this mutation.

    Authors: Muna Al Hashmi, Konduru S. Sastry, Lee Silcock, Lotfi Chouchane, Valentina Mattei, Nicola James, Rebecca Mathew, Davide Bedognetti, Valeria De Giorgi, Daniela Murtas, Wei Liu, Aouatef Chouchane, Ramzi Temanni, Barbara Seliger, Ena Wang, Francesco M. Marincola…

    Citation: Journal of Translational Medicine 2020 18:192

    Content type: Research

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  23. Genetically engineered T cells have become an important therapy for B-cell malignancies. Measuring the efficiency of vector integration into the T cell genome is important for assessing the potency and safety ...

    Authors: Alex Lu, Hui Liu, Rongye Shi, Yihua Cai, Jinxia Ma, Lipei Shao, Victor Rong, Nikolaos Gkitsas, Hong Lei, Steven L. Highfill, Sandhya Panch, David F. Stroncek and Ping Jin

    Citation: Journal of Translational Medicine 2020 18:191

    Content type: Research

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  24. The modified Gompertz equation has been proposed to fit experimental data for direct current treated tumors when multiple-straight needle electrodes are individually inserted into the base perpendicular to the...

    Authors: Narciso Antonio Villar Goris, Jorge Luis García Rodríguez, Maraelys Morales González, Beatriz Olivares Borges, Dasha Fuentes Morales, Enaide Maine Calzado, Antonio Rafael Selva Castañeda, Leonardo Mesa Torres, Juan Ignacio Montijano, Victoriano Gustavo Sierra González, Daniel Jay Pérez, Oscar Ortiz Posada, Janet Avellanet Martínez, Arlem García Delgado, Karina García Martínez, Mayrel Labrada Mon…

    Citation: Journal of Translational Medicine 2020 18:190

    Content type: Research

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  25. The protective role of high HDL cholesterol levels against cardiovascular diseases has been recently questioned. Limited data are available on this specific topic in patients with type 2 diabetes mellitus (T2D...

    Authors: Giovanni Fanni, Rosalba Rosato, Luigi Gentile, Matteo Anselmino, Simone Frea, Valentina Ponzo, Marianna Pellegrini, Fabio Broglio, Francesca Pivari, Gaetano Maria De Ferrari, Ezio Ghigo and Simona Bo

    Citation: Journal of Translational Medicine 2020 18:189

    Content type: Research

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  26. The prognosis of patients with advanced schistosomiasis is poor. Pre-existing prognosis studies did not differentiate the causes of the deaths. The objectives were to evaluate the 2-year overall survival (OS) ...

    Authors: Guo Li, Lifei Lian, Shanshan Huang, Jinfeng Miao, Huan Cao, Chengchao Zuo, Xiaoyan Liu and Zhou Zhu

    Citation: Journal of Translational Medicine 2020 18:187

    Content type: Research

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  27. Sjögren’s syndrome (SS) is an autoimmune disease mediated by lymphocytic infiltration into exocrine glands, resulting in progressive lacrimal and salivary destruction and dysfunctional glandular secretion. Met...

    Authors: Sun-Hee Hwang, Jin-Sil Park, SeungCheon Yang, Kyung-Ah Jung, JeongWon Choi, Seung-Ki Kwok, Sung-Hwan Park and Mi-La Cho

    Citation: Journal of Translational Medicine 2020 18:186

    Content type: Research

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  28. A new human coronavirus named SARS-CoV-2 was identified in several cases of acute respiratory syndrome in Wuhan, China in December 2019. On March 11 2020, WHO declared the SARS-CoV-2 infection to be a pandemic...

    Authors: Luigi Buonaguro, Maria Tagliamonte, Maria Lina Tornesello and Franco M. Buonaguro

    Citation: Journal of Translational Medicine 2020 18:185

    Content type: Commentary

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  29. Primary glomerulonephritis (GN) is the leading cause of chronic kidney disease (CKD) and frequently progresses into end stage renal diseases (ESRDs). Shorter leukocyte telomere length (LTL) has been implicated...

    Authors: Qing Sun, Junli Liu, Guanghui Cheng, Mingkai Dai, Jiaxi Liu, Zhenqiang Qi, Jingjie Zhao, Wei Li, Feng Kong, Gang Liu, Magnus Björkholm and Dawei Xu

    Citation: Journal of Translational Medicine 2020 18:184

    Content type: Research

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  30. Osteosarcoma is a highly metastatic primary bone tumor that predominantly affects adolescents and young adults. A mainstay of treatment in osteosarcoma is removal of the primary tumor. However, surgical excisi...

    Authors: Michelle P. Kallis, Caroline Maloney, Brandon Blank, Samuel Z. Soffer, Marc Symons and Bettie M. Steinberg

    Citation: Journal of Translational Medicine 2020 18:183

    Content type: Research

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  31. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Haihua Chen, Qixin Gan, Congying Yang, Xiongqun Peng, Jiao Qin, Sisi Qiu, Yanzhi Jiang, Sha Tu, Ying He, Shenglan Li, Huixiang Yang, Lijian Tao and Yu Peng

    Citation: Journal of Translational Medicine 2020 18:182

    Content type: Correction

    Published on:

    The original article was published in Journal of Translational Medicine 2019 17:280

  32. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Anne Clavreul, Gwénaëlle Soulard, Jean-Michel Lemée, Marion Rigot, Pascale Fabbro-Peray, Luc Bauchet, Dominique Figarella-Branger and Philippe Menei

    Citation: Journal of Translational Medicine 2020 18:181

    Content type: Correction

    Published on:

    The original article was published in Journal of Translational Medicine 2019 17:133

  33. This commentary presents the vision of the International Consortium for Personalised Medicine (ICPerMed) on how personalised medicine (PM) will lead to the next generation of healthcare by 2030. This vision fo...

    Authors: Astrid M. Vicente, Wolfgang Ballensiefen and Jan-Ingvar Jönsson

    Citation: Journal of Translational Medicine 2020 18:180

    Content type: Commentary

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  34. SARS-CoV-2 is a RNA coronavirus responsible for the pandemic of the Severe Acute Respiratory Syndrome (COVID-19). RNA viruses are characterized by a high mutation rate, up to a million times higher than that o...

    Authors: Maria Pachetti, Bruna Marini, Francesca Benedetti, Fabiola Giudici, Elisabetta Mauro, Paola Storici, Claudio Masciovecchio, Silvia Angeletti, Massimo Ciccozzi, Robert C. Gallo, Davide Zella and Rudy Ippodrino

    Citation: Journal of Translational Medicine 2020 18:179

    Content type: Research

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  35. Systemic inflammatory response in colorectal cancer (CRC) has been established as a prognostic factor for impaired cancer-specific survival, predominantly in patients with right-sided tumors. On the other hand...

    Authors: Ulf Gunnarsson, Karin Strigård, Sofia Edin, Ioannis Gkekas, Harri Mustonen, Tuomas Kaprio, Camilla Böckelman, Jaana Hagström, Richard Palmqvist and Caj Haglund

    Citation: Journal of Translational Medicine 2020 18:178

    Content type: Research

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  36. Progressive multifocal leukoencephalopathy is a demyelinating CNS disorder. Reactivation of John Cunningham virus leads to oligodendrocyte infection with lysis and consequent axonal loss due to demyelination. ...

    Authors: M. J. Steinhardt, E. Wiercinska, M. Pham, G. U. Grigoleit, A. Mazzoni, M. Da-Via, X. Zhou, K. Meckel, K. Nickel, J. Duell, F. C. Krummenast, S. Kraus, C. Hopkinson, B. Weissbrich, W. Müllges, G. Stoll…

    Citation: Journal of Translational Medicine 2020 18:177

    Content type: Methodology

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  37. In a randomized phase II trial conducted in patients with metastatic melanoma, patient-specific autologous dendritic cell vaccines (DCV) were associated with longer survival than autologous tumor cell vaccines...

    Authors: Gabriel I. Nistor and Robert O. Dillman

    Citation: Journal of Translational Medicine 2020 18:176

    Content type: Research

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  38. Kidney ischemia reperfusion injury (IRI) is a common cause of acute kidney injury and an unavoidable consequence of kidney transplantation and still lacks specific therapeutics. Recently, mesenchymal stem cell...

    Authors: Shuo Wang, Songjie Cai, Weitao Zhang, Xigao Liu, Yan Li, Chao Zhang, Yigang Zeng, Ming Xu, Ruiming Rong, Tianshu Yang, Benkang Shi, Anil Chandraker, Cheng Yang and Tongyu Zhu

    Citation: Journal of Translational Medicine 2020 18:175

    Content type: Research

    Published on:

  39. In sepsis, the endothelial barrier becomes incompetent, with the leaking of plasma into interstitial tissues. VE-cadherin, an adherens junction protein, is the gatekeeper of endothelial cohesion. Kinins, relea...

    Authors: Stéphanie Ruiz, Fanny Vardon-Bounes, Marie Buléon, Céline Guilbeau-Frugier, Marie-Hélène Séguelas, Jean-Marie Conil, Jean-Pierre Girolami, Ivan Tack and Vincent Minville

    Citation: Journal of Translational Medicine 2020 18:174

    Content type: Research

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  40. In myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), altered membrane excitability often occurs in exercising muscles demonstrating muscle dysfunction regardless of any psychiatric disorder. Increas...

    Authors: Yves Jammes, Nabil Adjriou, Nathalie Kipson, Christine Criado, Caroline Charpin, Stanislas Rebaudet, Chloé Stavris, Régis Guieu, Emmanuel Fenouillet and Frédérique Retornaz

    Citation: Journal of Translational Medicine 2020 18:173

    Content type: Research

    Published on:

  41. Recently, the role of IL-19, IL-20 and IL-24 has been reported in renal disorders. However, still little is known about their biological role.

    Authors: Domonkos Pap, Apor Veres-Székely, Beáta Szebeni, Réka Rokonay, Anna Ónody, Rita Lippai, István Márton Takács, András Tislér, Magdolna Kardos, Franz Oswald, Andrea Fekete, Attila J. Szabó and Ádám Vannay

    Citation: Journal of Translational Medicine 2020 18:172

    Content type: Research

    Published on:

  42. The Great Debate session at the 2019 Melanoma Bridge congress (December 5-7, Naples, Italy) featured counterpoint views from experts on five topical issues in melanoma. These were whether to choose local intra...

    Authors: Paolo A. Ascierto, Sanjiv S. Agarwala, Alexander Eggermont, Jeffrey E. Gershenwald, Jean-Jacques Grob, Omid Hamid, Olivier Michielin, Michael Postow, Igor Puzanov, Hassane M. Zarour, Corrado Caracò and Alessandro Testori

    Citation: Journal of Translational Medicine 2020 18:171

    Content type: Meeting report

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  43. Papillary thyroid carcinoma (PTC), which is the most common endocrine malignancy, has been steadily increasing worldwide in incidence over the years, while mechanisms underlying the pathogenesis and diagnostic...

    Authors: Yang Liu, Ting-Yu Chen, Zhi-Yan Yang, Wei Fang, Qian Wu and Chao Zhang

    Citation: Journal of Translational Medicine 2020 18:170

    Content type: Research

    Published on:

  44. The mechanisms underlying the therapeutic activity of interferon-β in multiple sclerosis are still not completely understood. In the present study, we evaluated the short and long-term effects of interferon-β ...

    Authors: Marco Chiarini, Ruggero Capra, Federico Serana, Diego Bertoli, Alessandra Sottini, Viviana Giustini, Cristina Scarpazza, Marco Rovaris, Valentina Torri Clerici, Diana Ferraro, Simonetta Galgani, Claudio Solaro, Marta Zaffira Conti, Andrea Visconti and Luisa Imberti

    Citation: Journal of Translational Medicine 2020 18:169

    Content type: Research

    Published on:

  45. Neutrophil chemotaxis plays a vital role in human immune system. Compared with traditional cell migration assays, the emergence of microfluidics provides a new research platform of cell chemotaxis study due to...

    Authors: Wenjie Zhao, Haiping Zhao, Mingxiao Li and Chengjun Huang

    Citation: Journal of Translational Medicine 2020 18:168

    Content type: Review

    Published on:

  46. Early detection of treatment failure may improve clinical outcome and overall survival in patients with head and neck cancer after first-line treatment. Circulating cell-free HPV16 DNA (cfHPV16 DNA) was evalua...

    Authors: Tomasz W. Rutkowski, Agnieszka M. Mazurek, Mirosław Śnietura, Beata Hejduk, Maja Jędrzejewska, Barbara Bobek-Billewicz, Andrea d’Amico, Wojciech Pigłowski, Andrzej Wygoda, Krzysztof Składowski, Zofia Kołosza and Piotr Widłak

    Citation: Journal of Translational Medicine 2020 18:167

    Content type: Research

    Published on:

  47. 17AAG has been extensively studied for its antitumor effects that protect cells from lethal stress by maintaining protein stability. The role of 17AAG in sevoflurane-induced neuronal injury has never been stud...

    Authors: Min Liu, Moyun Li, Yu Zhou, Qian Zhou and Yugang Jiang

    Citation: Journal of Translational Medicine 2020 18:166

    Content type: Research

    Published on:

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