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  1. Dysregulation of inflammation can lead to multiple chronic respiratory diseases, such as chronic obstructive pulmonary disease (COPD) and asthma. Interleukin-6 (IL6) is crucial in regulating the inflammatory c...

    Authors: Dongsheng Wu, Zhipeng Gong, Xiaohu Hao and Lunxu Liu
    Citation: Journal of Translational Medicine 2024 22:581
  2. The importance of the immune microenvironment in poorly cohesive carcinoma (PCC) has been highlighted due to its limited response rate to conventional therapy and emerging treatment resistance. A combination o...

    Authors: Yuan-jie Liu, Jie-pin Li, Mei Han, Jing-xiao Li, Qian-wen Ye, Si-tian Lin, Jin-yong Zhou, Shen-lin Liu and Xi Zou
    Citation: Journal of Translational Medicine 2024 22:580
  3. This study developed a nomogram model using CT-based delta-radiomics features and clinical factors to predict pathological complete response (pCR) in esophageal squamous cell carcinoma (ESCC) patients receivin...

    Authors: Liyuan Fan, Zhe Yang, Minghui Chang, Zheng Chen and Qiang Wen
    Citation: Journal of Translational Medicine 2024 22:579
  4. IDH1-wildtype glioblastoma multiforme (IDHwt-GBM) is a highly heterogeneous and aggressive brain tumour characterised by a dismal prognosis and significant challenges in accurately predicting patient outcomes....

    Authors: Qiang Ji, Yi Zheng, Lili Zhou, Feng Chen and Wenbin Li
    Citation: Journal of Translational Medicine 2024 22:578
  5. Inherited variations in DNA double-strand break (DSB) repair pathway are known to influence ovarian cancer occurrence, progression and treatment response. Despite its significance, survival-associated genetic ...

    Authors: Haoran Li, Jiao Wu, Qing Xu, Yangyang Pang, Yanzi Gu, Mengyun Wang and Xi Cheng
    Citation: Journal of Translational Medicine 2024 22:577
  6. Identifying new biomarkers for predicting immune checkpoint inhibitors (ICIs) response in non-small cell lung cancer (NSCLC) is crucial. We aimed to assess the variant allele frequency (VAF)-related profile as...

    Authors: Ruyun Gao, Ning Lou, Lin Li, Tongji Xie, Puyuan Xing, Le Tang, Jiarui Yao, Xiaohong Han and Yuankai Shi
    Citation: Journal of Translational Medicine 2024 22:576
  7. The vaginal microbiome is an immune defense against reproductive diseases and can serve as an important biomarker for cervical cancer. However, the intrinsic relationship between the recurrence and the vaginal...

    Authors: Yichen Wang, Tingzhang Wang, Dingding Yan, Hongxia Zhao, Meixia Wang, Tingting Liu, Xiaoji Fan and Xiaoxian Xu
    Citation: Journal of Translational Medicine 2024 22:575
  8. The innate immunity acts during the early phases of infection and its failure in response to a multilayer network of co-infections is cause of immune system dysregulation. Epidemiological SARS-CoV-2 infections...

    Authors: Veronica Ferrucci, Marco Miceli, Chiara Pagliuca, Orazio Bianco, Luigi Castaldo, Luana Izzo, Marica Cozzolino, Carla Zannella, Franca Oglio, Antonio Polcaro, Antonio Randazzo, Roberta Colicchio, Massimiliano Galdiero, Roberto Berni Canani, Paola Salvatore and Massimo Zollo
    Citation: Journal of Translational Medicine 2024 22:574
  9. Authors: Daniel I. Rhon, Julie M. Fritz, Tina A. Greenlee, Katie E. Dry, Rachel J. Mayhew, Mary C. Laugesen, Edita Dragusin and Deydre S. Teyhen
    Citation: Journal of Translational Medicine 2024 22:573

    The original article was published in Journal of Translational Medicine 2021 19:357

  10. Accurately identifying the risk level of drug combinations is of great significance in investigating the mechanisms of combination medication and adverse reactions. Most existing methods can only predict wheth...

    Authors: Shi-Hui He, Lijun Yun and Hai-Cheng Yi
    Citation: Journal of Translational Medicine 2024 22:572
  11. No reliable clinical tools exist to predict acute kidney injury (AKI) progression. We aim to explore a scoring system for predicting the composite outcome of progression to severe AKI or death within seven day...

    Authors: Ying Su, Peng Wang, Yan Hu, Wen-jun Liu, Yi-jie Zhang, Jia-qi Chen, Yi-zhi Deng, Shuang Lin, Yue Qiu, Jia-kun Li, Chen Chen, Guo-wei Tu and Zhe Luo
    Citation: Journal of Translational Medicine 2024 22:571
  12. Gut microbiota (GM) have been implicated as important regulators of gastrointestinal symptom which is commonly occurred along with respiratory influenza A virus (IAV) infection, suggesting the involvement of t...

    Authors: Lei Hu, Li Sun, Chun Yang, Da-Wei Zhang, Yuan-Yuan Wei, Ming-Ming Yang, Hui-Mei Wu and Guang-He Fei
    Citation: Journal of Translational Medicine 2024 22:570
  13. Cancer remains a leading cause of mortality and poses a substantial threat to public health. Studies have revealed that Long noncoding RNA DANCR is a cytoplasmic lncRNA whose aberrant expression plays a pivota...

    Authors: Rong Yuan, Zhao-jun Xu, Sheng-kang Zhang, Xian-ya Cao, Ai-guo Dai and Lan Song
    Citation: Journal of Translational Medicine 2024 22:569
  14. Metastasis renal cell carcinoma (RCC) patients have extremely high mortality rate. A predictive model for RCC micrometastasis based on pathomics could be beneficial for clinicians to make treatment decisions.

    Authors: Feng Gao, Liren Jiang, Tuanjie Guo, Jun Lin, Weiqing Xu, Lin Yuan, Yaqin Han, Jiji Yang, Qi Pan, Enhui Chen, Ning Zhang, Siteng Chen and Xiang Wang
    Citation: Journal of Translational Medicine 2024 22:568
  15. Both cancer and fibrosis are diseases involving dysregulation of cell signaling pathways resulting in an altered cellular microenvironment which ultimately leads to progression of the condition. The two diseas...

    Authors: Alireza Baniasadi, Jeeban P. Das, Conor M. Prendergast, Zahra Beizavi, Hong Y. Ma, Muhammad Yaman Jaber and Kathleen M. Capaccione
    Citation: Journal of Translational Medicine 2024 22:567
  16. Authors: Halvard Bonig, Mareike Verbeek, Peter Herhaus, Krischan Braitsch, Gernot Beutel, Christoph Schmid, Nadine Müller, Gesine Bug, Michaela Döring, Arend von Stackelberg, Johanna Tischer, Francis Ayuk, Gerald Wulf, Udo Holtick, Lisa‑Marie Pfeffermann, Bernd Jahrsdörfer…
    Citation: Journal of Translational Medicine 2024 22:566

    The original article was published in Journal of Translational Medicine 2023 21:837

  17. Wnt/β-catenin signaling is a critical pathway that influences development and therapeutic response of non-small cell lung cancer (NSCLC). In recent years, many Wnt regulators, including proteins, miRNAs, lncRN...

    Authors: Zixu Zhang, David Westover, Zhantong Tang, Yue Liu, Jinghan Sun, Yunxi Sun, Runqing Zhang, Xingyue Wang, Shihui Zhou, Nigaerayi Hesilaiti, Qi Xia and Zhenfang Du
    Citation: Journal of Translational Medicine 2024 22:565
  18. The gut microbiota and its metabolites play crucial roles in pathogenesis of arthritis, highlighting gut microbiota as a promising avenue for modulating autoimmunity. However, the characterization of the gut v...

    Authors: Chang-Ming Chen, Qiu-Long Yan, Ruo-Chun Guo, Fang Tang, Min-Hui Wang, Han-Zhi Yi, Chun-Xia Huang, Can Liu, Qiu-Yi Wang, Wei-Ya Lan, Zong Jiang, Yu-Zheng Yang, Guang-Yang Wang, Ai-Qin Zhang, Jie Ma, Yan Zhang…
    Citation: Journal of Translational Medicine 2024 22:564
  19. In recent years, single-cell analyses have revealed the heterogeneity of the tumour microenvironment (TME) at the genomic, transcriptomic, and proteomic levels, further improving our understanding of the mecha...

    Authors: Jie Zhu, Ke Zhang, Yuan Chen, Xinyu Ge, Junqing Wu, Peng Xu and Jie Yao
    Citation: Journal of Translational Medicine 2024 22:563
  20. Intravitreal injections of angiogenesis inhibitors have proved efficacious in the majority of patients with ocular angiogenesis. However, one-fourth of all treated patients fail to derive benefits from intravi...

    Authors: Yan Ma, Ying Zhang, Hui-Ying Zhang, Ya Zhao, Xiu-Miao Li, Yi-Fei Jiang, Mu-Di Yao, Qin Jiang and Biao Yan
    Citation: Journal of Translational Medicine 2024 22:562
  21. Fibrogenesis within ovarian endometrioma (endometrioma), mainly induced by transforming growth factor-β (TGF-β), is characterized by myofibroblast over-activation and excessive extracellular matrix (ECM) depos...

    Authors: Yi Gong, Mian Liu, Qianqian Zhang, Jinjing Li, Hong Cai, Jing Ran, Linna Ma, Yanlin Ma and Song Quan
    Citation: Journal of Translational Medicine 2024 22:561
  22. Cardiac fibrosis after myocardial infarction (MI) has been considered an important part of cardiac pathological remodeling. Immune cells, especially macrophages, are thought to be involved in the process of fi...

    Authors: Da Ke, Mingzhen Cao, Jian Ni, Yuan Yuan, Jiangyang Deng, Si Chen, Xiujun Dai and Heng Zhou
    Citation: Journal of Translational Medicine 2024 22:560
  23. Exploration of adaptive evolutionary changes at the genetic level in vaginal microbial communities during different stages of cervical cancer remains limited. This study aimed to elucidate the mutational profi...

    Authors: Menglu Hu, Wentao Yang, Ruiyi Yan, Jiayu Chi, Qi Xia, Yilin Yang, Yinhan Wang, Lejia Sun and Ping Li
    Citation: Journal of Translational Medicine 2024 22:559
  24. The purpose of the study was to evaluate the expression and function of basic leucine zipper ATF-like transcription factor (BATF) in colorectal cancer (CRC), and its correlation with 2-deoxy-2[18F]fluoro-d-glucos...

    Authors: Xia Lu, Jun Liu, Lijuan Feng, Yan Huang, Yanfeng Xu, Cuicui Li, Wei Wang, Yin Kan, Jigang Yang and Mingyu Zhang
    Citation: Journal of Translational Medicine 2024 22:558
  25. Deciphering the role of plasma proteins in pancreatic cancer (PC) susceptibility can aid in identifying novel targets for diagnosis and treatment.

    Authors: Siyu Zhou, Baian Tao, Yujie Guo, Jichun Gu, Hengchao Li, Caifeng Zou, Sichong Tang, Shuheng Jiang, Deliang Fu and Ji Li
    Citation: Journal of Translational Medicine 2024 22:557
  26. The poor chemo-response and high DNA methylation of ovarian clear cell carcinoma (OCCC) have attracted extensive attentions. Recently, we revealed the mutational landscape of the human kinome and additional ca...

    Authors: Shang Li, Gert Jan Meersma, Jolanta Kupryjanczyk, Steven de Jong and G. Bea A. Wisman
    Citation: Journal of Translational Medicine 2024 22:556
  27. Astragaloside IV (AST-IV), as an effective active ingredient of Astragalus membranaceus (Fisch.) Bunge. It has been found that AST-IV inhibits the replication of dengue virus, hepatitis B virus, adenovirus, an...

    Authors: JinFang Hao, Xiaoyan Zhang, Ruixian Hu, Xiufeng Lu, Hui Wang, Yuanhong Li, Kai Cheng and Qingshan Li
    Citation: Journal of Translational Medicine 2024 22:555
  28. The molecular complexity of colorectal cancer poses a significant challenge to the clinical implementation of accurate risk stratification. There is still an urgent need to find better biomarkers to enhance es...

    Authors: Xiangchou Yang, Jieyu Liu, Shuaibin Wang, Wail Hussein Ahmed Al-Ameer, Jingting Ji, Jiaqi Cao, Hassan Mansour S Dhaen, Ying Lin, Yangyang Zhou and Chenguo Zheng
    Citation: Journal of Translational Medicine 2024 22:554
  29. Gamma delta (γδ) T cells demonstrate strong cytotoxicity against diverse cancer cell types in an MHC-independent manner, rendering them promising contenders for cancer therapy. Although amplification and adopt...

    Authors: Jian Liu, Min Wu, Yifan Yang, Zixuan Wang, Shan He, Xun Tian and Hui Wang
    Citation: Journal of Translational Medicine 2024 22:553
  30. Acute myocardial infarction (AMI) is a serious condition that occurs when part of the heart is subjected to ischemia episodes, following partial or complete occlusion of the epicardial coronary arteries. The r...

    Authors: Esther Densu Agyapong, Gaia Pedriali, Daniela Ramaccini, Esmaa Bouhamida, Elena Tremoli, Carlotta Giorgi, Paolo Pinton and Giampaolo Morciano
    Citation: Journal of Translational Medicine 2024 22:552
  31. Glioblastoma (GBM) is a highly heterogeneous, recurrent and aggressively invasive primary malignant brain tumor. The heterogeneity of GBM results in poor targeted therapy. Therefore, the aim of this study is t...

    Authors: Liping Wang, Xinyi Li, Chengshi Xu, Danwen Wang, Chao Ma, Zefen Wang, Yirong Li and Zhiqiang Li
    Citation: Journal of Translational Medicine 2024 22:551
  32. The coronavirus disease 2019 (COVID-19) has become a serious public health issue. In COVID-19 patients, the elevated levels of inflammatory cytokines lead to the manifestation of COVID-19 symptoms, such as lun...

    Authors: Wenming Lu, Longxiang Yan, Xingkun Tang, Xuesong Wang, Jing Du, Zhengwei Zou, Lincai Li, Junsong Ye and Lin Zhou
    Citation: Journal of Translational Medicine 2024 22:550
  33. Cellular communication (CC) influences tumor development by mediating intercellular junctions between cells. However, the role and underlying mechanisms of CC in malignant transformation remain unknown. Here, ...

    Authors: Jie-pin Li, Yuan-jie Liu, Yang Li, Yi Yin, Qian-wen Ye, Zhi-hua Lu, Yu-wei Dong, Jin-yong Zhou, Xi Zou and Yu-gen Chen
    Citation: Journal of Translational Medicine 2024 22:549
  34. Despite significant advancements in treatment strategies, multiple myeloma remains incurable. Additionally, there is a distinct lack of reliable biomarkers that can guide initial treatment decisions and help d...

    Authors: Sigrid Ravn Berg, Aida Dikic, Animesh Sharma, Lars Hagen, Cathrine Broberg Vågbø, Alexey Zatula, Kristine Misund, Anders Waage and Geir Slupphaug
    Citation: Journal of Translational Medicine 2024 22:548
  35. Enhancers are important gene regulatory elements that promote the expression of critical genes in development and disease. Aberrant enhancer can modulate cancer risk and activate oncogenes that lead to the occ...

    Authors: Junyou Zhang, Qilin Wang, Sihan Qi, Yingying Duan, Zhaoshuo Liu, Jiaxin Liu, Ziyi Zhang and Chunyan Li
    Citation: Journal of Translational Medicine 2024 22:547
  36. The pathogenesis of thyroid-associated orbitopathy (TAO) remains incompletely understand. The interaction between immunocytes and orbital fibroblasts (OFs) play a critical role in orbital inflammatory and fibr...

    Authors: Li Wei, Qinying Huang, Yunhai Tu, Shihan Song, Xiaobo Zhang, Bo Yu, Yufen Liu, Ziwei Li, Qing Huang, Lili Chen, Bo Liu, Shenglan Xu, Tong Li, Xiyuan Liu, Xiaozhou Hu, Weijie Liu…
    Citation: Journal of Translational Medicine 2024 22:546
  37. Recently, research on the human microbiome, especially concerning the bacteria within the digestive system, has substantially advanced. This exploration has unveiled a complex interplay between microbiota and ...

    Authors: Weiqin Lu, Aihemaitijiang Aihaiti, Paziliya Abudukeranmu, Yajun Liu and Huihui Gao
    Citation: Journal of Translational Medicine 2024 22:545
  38. Several studies have demonstrated a strong correlation between impaired Succinate dehydrogenase (SDH) function and the advancement of tumors. As a subunit of SDH, succinate dehydrogenase complex subunit C (SDH...

    Authors: Zhuoyu Ding, Yiyi Wei, Jingping Dai, Chaomin Pan, Li Yang, Qingyuan Li, Yue Zhang, Qun Yan, Changjie Wu, Aimin Li, Zhixian Lan, Side Liu and Xinke Wang
    Citation: Journal of Translational Medicine 2024 22:544
  39. Hepatocellular carcinoma (HCC) is a common malignant tumor, and glutamine is vital for tumor cells. The role of glutamine transporter SLC1A5 in tumor progression and transarterial chemoembolization (TACE) effi...

    Authors: Guixiong Zhang, Yitai Xiao, Jizhou Tan, Hang Liu, Wenzhe Fan and Jiaping Li
    Citation: Journal of Translational Medicine 2024 22:543
  40. Dendritic cells (DCs) have been intensively studied in correlation to tumor immunology and for the development DC-based cancer vaccines. Here, we present the significance of the temporal aspect of DC maturatio...

    Authors: Primož Poženel, Kaja Zajc and Urban Švajger
    Citation: Journal of Translational Medicine 2024 22:541
  41. The adaptability of glioblastoma (GBM) cells, encouraged by complex interactions with the tumour microenvironment (TME), currently renders GBM an incurable cancer. Despite intensive research, with many clinica...

    Authors: Jasmine White, Madeleine P. J. White, Agadha Wickremesekera, Lifeng Peng and Clint Gray
    Citation: Journal of Translational Medicine 2024 22:540
  42. Apalutamide, a novel endocrine therapy agent, has been shown to significantly improve the prognosis of patients with metastatic hormone-sensitive prostate cancer (mHSPC). However, resistance to apalutamide has...

    Authors: Zihao Qi, Xiaojie Bai, Linjie Wu, Peng Zhang, Zhongqiang Guo and Ying Yu
    Citation: Journal of Translational Medicine 2024 22:538
  43. Accumulating evidence indicated that HHEX participated in the initiation and development of several cancers, but the potential roles and mechanisms of HHEX in hepatocellular carcinoma (HCC) were largely unclea...

    Authors: Huizi Li, Jin Liu, Jie Lai, Xinyao Su, Xiaofeng Wang, Jiaqing Cao, Shengxun Mao, Tong Zhang and Qiuping Gu
    Citation: Journal of Translational Medicine 2024 22:537
  44. The challenge of addressing obesity persists in healthcare, necessitating nuanced approaches and personalized strategies. This study aims to evaluate the effects of diverse therapeutic interventions on anthrop...

    Authors: Keyvan Khorrami Chokami, Amir Khorrami Chokami, Giuseppe Cammarata, Grazia Piras, Manuela Albertelli, Federico Gatto, Lara Vera, Diego Ferone and Mara Boschetti
    Citation: Journal of Translational Medicine 2024 22:536
  45. Inflammation and endothelial barrier dysfunction are the major pathophysiological changes in acute respiratory distress syndrome (ARDS). Sphingosine-1-phosphate receptor 3 (S1PR3), a G protein-coupled receptor...

    Authors: Junnan Peng, Rui Tang, Jing He, Qian Yu, Daoxin Wang and Di Qi
    Citation: Journal of Translational Medicine 2024 22:535
  46. Macrophages are involved in tissue homeostasis, angiogenesis and immunomodulation. Proangiogenic and anti-inflammatory macrophages (regulatory macrophages, Mreg) can be differentiated in-vitro from CD14+ monocyte...

    Authors: Karina Zitta, Lars Hummitzsch, Frank Lichte, Fred Fändrich, Markus Steinfath, Christine Eimer, Sebastian Kapahnke, Matthias Buerger, Katharina Hess, Melanie Rusch, Rene Rusch, Rouven Berndt and Martin Albrecht
    Citation: Journal of Translational Medicine 2024 22:534
  47. Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a debilitating illness medically unexplained, affecting approximately 1% of the global population. Due to the subjective complaint, assessing the ...

    Authors: Jae-Woong Park, Byung-Jin Park, Jin-Seok Lee, Eun-Jung Lee, Yo-Chan Ahn and Chang-Gue Son
    Citation: Journal of Translational Medicine 2024 22:529

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