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  1. Tocilizumab blocks pro-inflammatory activity of interleukin-6 (IL-6), involved in pathogenesis of pneumonia the most frequent cause of death in COVID-19 patients.

    Authors: Francesco Perrone, Maria Carmela Piccirillo, Paolo Antonio Ascierto, Carlo Salvarani, Roberto Parrella, Anna Maria Marata, Patrizia Popoli, Laurenzia Ferraris, Massimiliano M. Marrocco-Trischitta, Diego Ripamonti, Francesca Binda, Paolo Bonfanti, Nicola Squillace, Francesco Castelli, Maria Lorenza Muiesan, Miriam Lichtner…

    Citation: Journal of Translational Medicine 2020 18:405

    Content type: Research

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  2. Numerous tissue-derived factors have been postulated to be involved in tissue migration of circulating monocytes. The aim of this study was to evaluate whether a defined hypoxic gradient can induce directed mi...

    Authors: Lars Hummitzsch, Rouven Berndt, Matthias Kott, Rene Rusch, Fred Faendrich, Matthias Gruenewald, Markus Steinfath, Martin Albrecht and Karina Zitta

    Citation: Journal of Translational Medicine 2020 18:404

    Content type: Research

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  3. In a previous study, we reported that selective dorsal root ganglion stimulation (DRGSTIM) at DRG level L4 promoted a favorable outcome for complex regional pain syndrome (CRPS) patients along with DRGSTIM-relate...

    Authors: Thomas Kinfe, Nico von Willebrand, Andreas Stadlbauer, Michael Buchfelder, Thomas L. Yearwood, Sajjad Muhammad, Shafqat R. Chaudhry, Sascha Gravius, Thomas Randau, Klemens Winder, Christian Maihöfner, Nadine Gravius and Walter Magerl

    Citation: Journal of Translational Medicine 2020 18:403

    Content type: Research

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  4. Cancer vaccines provide a complex source of neoantigens. Still, increasing evidence reveals that the neoantigen quality rather than the quantity is predictive for treatment outcome.

    Authors: Inken Salewski, Yvonne Saara Gladbach, Steffen Kuntoff, Nina Irmscher, Olga Hahn, Christian Junghanss and Claudia Maletzki

    Citation: Journal of Translational Medicine 2020 18:402

    Content type: Research

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  5. Marine lipids contain omega-3 fatty acids that can be metabolized into anti-inflammatory and pro-resolving mediators—namely 17-HDHA and 18-HEPE—which can serve as modulators of the pain experience. The purpose...

    Authors: Nini Callan, Doug Hanes and Ryan Bradley

    Citation: Journal of Translational Medicine 2020 18:401

    Content type: Research

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  6. Contrast-induced nephropathy (CIN) or contrast-induced acute kidney injury (CI-AKI) is an iatrogenic acute kidney injury observed after intravascular administration of contrast media for intravascular diagnost...

    Authors: Prit Kusirisin, Siriporn C. Chattipakorn and Nipon Chattipakorn

    Citation: Journal of Translational Medicine 2020 18:400

    Content type: Review

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  7. Osteonecrosis (ON) is an acquired debilitating skeletal disorder, which is caused by a multitude of traumatic and non-traumatic etiological factors. Vascular damage, mechanical stress and increased intraosseou...

    Authors: S. Elgaz, H. Bonig and P. Bader

    Citation: Journal of Translational Medicine 2020 18:399

    Content type: Review

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  8. Bronchopulmonary dysplasia (BPD) is a severe condition in premature infants that compromises lung function and necessitates oxygen support. Despite major improvements in perinatal care minimizing the devastati...

    Authors: Liem Thanh Nguyen, Thai T. H. Trieu, Hue T. H. Bui, Van T. Hoang, Anh T. T. Nguyen, Nhung T. H. Trinh, Kien T. Nguyen and Duc M. Hoang

    Citation: Journal of Translational Medicine 2020 18:398

    Content type: Research

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  9. Very preterm infants are at risk of developing retinopathy of prematurity (ROP). Recombinant human erythropoietin (rhEPO) is routinely used to prevent anemia in preterm infants; however, the effect of rhEPO on...

    Authors: Huiqing Sun, Juan Song, Wenqing Kang, Yong Wang, Xiantao Sun, Chongchen Zhou, Hong Xiong, Falin Xu, Mingchao Li, Xiaoli Zhang, Zengyuan Yu, Xirui Peng, Bingbing Li, Yiran Xu, Shan Xing, Xiaoyang Wang…

    Citation: Journal of Translational Medicine 2020 18:397

    Content type: Research

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  10. Evidences support the view that central obesity is an independently cardiovascular risk. It is thought that leptin contributes to autonomic dysfunction and cardiovascular risks in type 1 and type 2 diabetes me...

    Authors: Yun-Ru Lai, Meng Hsiang Chen, Wei Che Lin, Wen-Chan Chiu, Ben-Chung Cheng, Jung-Fu Chen, Nai-Wen Tsai, Chih-Cheng Huang and Cheng-Hsien Lu

    Citation: Journal of Translational Medicine 2020 18:396

    Content type: Research

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  11. In Crohn’s disease (CD), one of the major inflammatory bowel disease (IBD) in human beings, there is over-expression of Smad7, an intracellular inhibitor of the suppressive cytokine TGF-β1. The aim of this stu...

    Authors: Francesca Zorzi, Emma Calabrese, Davide Di Fusco, Elena De Cristofaro, Livia Biancone, Sara Casella, Giampiero Palmieri and Giovanni Monteleone

    Citation: Journal of Translational Medicine 2020 18:395

    Content type: Research

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  12. Medical data from family doctors are of great importance to health care researchers but seem to be locked in German practices and, thus, are underused in research. The RADAR project (Routine Anonymized Data fo...

    Authors: Thomas Bahls, Johannes Pung, Stephanie Heinemann, Johannes Hauswaldt, Iris Demmer, Arne Blumentritt, Henriette Rau, Johannes Drepper, Philipp Wieder, Roland Groh, Eva Hummers and Falk Schlegelmilch

    Citation: Journal of Translational Medicine 2020 18:394

    Content type: Research

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  13. Methyltransferase-like 3 (METTL3) is a member of the m6A methyltransferase family and acts as an oncogene in cancers. Recent studies suggest that host innate immunity is regulated by the enzymes controlling m6A e...

    Authors: Huan-he Ni, Lin Zhang, He Huang, Shu-qin Dai and Jiang Li

    Citation: Journal of Translational Medicine 2020 18:393

    Content type: Research

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  14. Intracranial aneurysms (IAs) are dangerous because of their potential to rupture. We previously found significant RNA expression differences in circulating neutrophils between patients with and without unruptu...

    Authors: Kerry E. Poppenberg, Vincent M. Tutino, Lu Li, Muhammad Waqas, Armond June, Lee Chaves, Kaiyu Jiang, James N. Jarvis, Yijun Sun, Kenneth V. Snyder, Elad I. Levy, Adnan H. Siddiqui, John Kolega and Hui Meng

    Citation: Journal of Translational Medicine 2020 18:392

    Content type: Research

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  15. Glioblastoma multiforme (GBM) is the most malignant tumor in human brain. Diagnosis and treatment of GBM may lead to psychological disorders such as depressive and anxiety disorders. There was no research focu...

    Authors: Xiaojun Fu, Pei Zhang, Hongwang Song, Chenxing Wu, Shengzhen Li, Shouwei Li and Changxiang Yan

    Citation: Journal of Translational Medicine 2020 18:391

    Content type: Research

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  16. Rheumatoid arthritis (RA) and periodontitis (PD) are proven to share common risk markers, including genetic factors. In the present study we focused on genetic variants in PTPN22 (rs2476601), PADI4 (rs2240340), C...

    Authors: Susanne Schulz, Pauline Zimmer, Natalie Pütz, Elisa Jurianz, Hans-Günter Schaller and Stefan Reichert

    Citation: Journal of Translational Medicine 2020 18:389

    Content type: Research

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  17. Huntington’s disease (HD) is a neurodegenerative disorder characterized by psychiatric symptoms, serious motor and cognitive deficits. Certain pathological changes can already be observed in pre-symptomatic HD...

    Authors: Chunchen Xiang, Shengri Cong, Bin Liang and Shuyan Cong

    Citation: Journal of Translational Medicine 2020 18:388

    Content type: Research

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  18. Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a debilitating disease of unknown etiology lasting for a minimum of 6 months but usually for many years, with features including fatigue, cognitiv...

    Authors: Ludovic Giloteaux, Adam O’Neal, Jesús Castro-Marrero, Susan M. Levine and Maureen R. Hanson

    Citation: Journal of Translational Medicine 2020 18:387

    Content type: Research

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  19. From a global viewpoint, endometrial cancer belongs to the most common female cancers. Despite the heavy burden of diseases and numerous unanswered questions, no detailed pictures of the global structure of en...

    Authors: Dörthe Brüggmann, Katja Ouassou, Doris Klingelhöfer, Michael K. Bohlmann, Jenny Jaque and David A. Groneberg

    Citation: Journal of Translational Medicine 2020 18:386

    Content type: Research

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  20. Many contradictory conclusions pertaining to the telomere length in peripheral leukocyte chromosomes as a potential biomarker for ischemic stroke (IS) risk have been reported by the various observational studi...

    Authors: Weijie Cao, Deqiang Zheng, Jie Zhang, Anxin Wang, Di Liu, Jinxia Zhang, Manjot Singh, Isinta Elijah Maranga, Mingyang Cao, Lijuan Wu, Manshu Song, Wei Wang and Youxin Wang

    Citation: Journal of Translational Medicine 2020 18:385

    Content type: Research

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  21. Autoimmune hepatitis (AIH) is a liver disease characterized by the autoimmune-induced injury of hepatocytes which can lead to cirrhosis and hepatic failure. The diagnosis and disease management of AIH patients...

    Authors: Rui Wu, Yan Liu, Ruyu Yan, Xiaoyu Liu and Liang Duan

    Citation: Journal of Translational Medicine 2020 18:384

    Content type: Research

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  22. A major obstacle to anti-viral and -tumor cell vaccination and T cell immunotherapy is the ability to produce dendritic cells (DCs) in a suitable clinical setting. It is imperative to develop closed cell cultu...

    Authors: Jean-Philippe Bastien, Natalie Fekete, Ariane V. Beland, Marie-Paule Lachambre, Veronique Laforte, David Juncker, Vibhuti Dave, Denis-Claude Roy and Corinne A. Hoesli

    Citation: Journal of Translational Medicine 2020 18:383

    Content type: Research

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  23. The gut microbiota was shown to play a crucial role in the development of vascular dysfunction, and the bacterial composition differed between healthy controls and coronary artery disease patients. The goal of...

    Authors: Honghong Liu, Ran Tian, Hui Wang, Siqin Feng, Hanyu Li, Ying Xiao, Xiaodong Luan, Zhiyu Zhang, Na Shi, Haitao Niu and Shuyang Zhang

    Citation: Journal of Translational Medicine 2020 18:382

    Content type: Research

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  24. Sepsis is a leading cause of mortality and morbidity in the intensive care unit. Regulatory mechanisms underlying the disease progression and prognosis are largely unknown. The study aimed to identify master r...

    Authors: Zhongheng Zhang, Lin Chen, Ping Xu, Lifeng Xing, Yucai Hong and Pengpeng Chen

    Citation: Journal of Translational Medicine 2020 18:381

    Content type: Research

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  25. The incidence of stage I and stage II lung adenocarcinoma (LUAD) is likely to increase with the introduction of annual screening programs for high-risk individuals. We aimed to identify a reliable prognostic s...

    Authors: Pancheng Wu, Yi Zheng, Yanyu Wang, Yadong Wang and Naixin Liang

    Citation: Journal of Translational Medicine 2020 18:380

    Content type: Research

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  26. Electronic cigarette use is on the rise despite a number of reports linking electronic cigarettes with adverse health outcomes. Recent studies have suggested that alterations in lipid signaling may be one mech...

    Authors: Holly R. Middlekauff, Kevin J. William, Baolong Su, Kacey Haptonstall, Jesus A. Araujo, Xiaohui Wu, Jason Kim and Tamer Sallam

    Citation: Journal of Translational Medicine 2020 18:379

    Content type: Research

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  27. Molecular classification has laid the framework for exploring glioma biology and treatment strategies. Pro-neural to mesenchymal transition (PMT) of glioma is known to be associated with aggressive phenotypes,...

    Authors: Qingyu Liang, Gefei Guan, Xue Li, Chunmi Wei, Jianqi Wu, Peng Cheng, Anhua Wu and Wen Cheng

    Citation: Journal of Translational Medicine 2020 18:378

    Content type: Research

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  28. It is well established that thymidylate synthase inhibitors can cause cellular toxicity through uracil DNA glycosylase (UNG2)-dependent pathways. Additionally, thymidylate synthase inhibitors and HDAC inhibito...

    Authors: Meredith S. Showler and Brian P. Weiser

    Citation: Journal of Translational Medicine 2020 18:377

    Content type: Commentary

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  29. It often takes more than 10 years and costs more than 1 billion dollars to develop a new drug for a particular disease and bring it to the market. Drug repositioning can significantly reduce costs and time in ...

    Authors: Ghazale Fahimian, Javad Zahiri, Seyed Shahriar Arab and Reza H. Sajedi

    Citation: Journal of Translational Medicine 2020 18:375

    Content type: Research

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  30. Cannabis has been documented for use in alleviating anxiety. However, certain research has also shown that it can produce feelings of anxiety, panic, paranoia and psychosis. In humans, Δ9-tetrahydrocannabinol (TH...

    Authors: Lara Sharpe, Justin Sinclair, Andrew Kramer, Michael de Manincor and Jerome Sarris

    Citation: Journal of Translational Medicine 2020 18:374

    Content type: Research

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  31. Elevated lipoprotein(a) [Lp(a)] and fibrinogen (Fib) are both associated with coronary artery disease (CAD). The atherogenicity of Lp(a) can be partly due to the potentially antifibrinolytic categories. We hyp...

    Authors: Yan Zhang, Jing-Lu Jin, Ye-Xuan Cao, Hui-Hui Liu, Hui-Wen Zhang, Yuan-Lin Guo, Na-Qiong Wu, Ying Gao, Qi Hua, Yan-Fang Li, Rui-Xia Xu, Chuan-Jue Cui, Geng Liu, Qian Dong, Jing Sun and Jian-Jun Li

    Citation: Journal of Translational Medicine 2020 18:373

    Content type: Research

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  32. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Qiuyan Guo, Xia Mao, Yanqiong Zhang, Shuqin Meng, Yue Xi, Yi Ding, Xiaocun Zhang, Yuntao Dai, Xia Liu, Chao Wang, Yuting Li and Na Lin

    Citation: Journal of Translational Medicine 2020 18:372

    Content type: Correction

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    The original article was published in Journal of Translational Medicine 2016 14:165

  33. The non-classical human leukocyte antigen (HLA)-G is a strong immunomodulatory molecule. Under physiological conditions, HLA-G induces immunological tolerance in immune privileged tissues, while under pathophy...

    Authors: Michael Friedrich, Christine Stoehr, Simon Jasinski-Bergner, Arndt Hartmann, Sven Wach, Bernd Wullich, André Steven and Barbara Seliger

    Citation: Journal of Translational Medicine 2020 18:371

    Content type: Research

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  34. Kidney transplantation is the optimal treatment to cure the patients with end-stage renal disease (ESRD). However, the infectious complication, especially pneumonia, is the main cause of mortality in the early...

    Authors: Bo Peng, Hang Gong, Han Tian, Quan Zhuang, Junhui Li, Ke Cheng and Yingzi Ming

    Citation: Journal of Translational Medicine 2020 18:370

    Content type: Research

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  35. The complexities of modern biomedicine are rapidly increasing. Thus, modeling and simulation have become increasingly important as a strategy to understand and predict the trajectory of pathophysiology, diseas...

    Authors: Ahmet Erdemir, Lealem Mulugeta, Joy P. Ku, Andrew Drach, Marc Horner, Tina M. Morrison, Grace C. Y. Peng, Rajanikanth Vadigepalli, William W. Lytton and Jerry G. Myers Jr.

    Citation: Journal of Translational Medicine 2020 18:369

    Content type: Review

    Published on:

  36. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Hao Zhang, Fan Fan, Yuanqiang Yu, Zeyu Wang, Fangkun Liu, Ziyu Dai, Liyang Zhang, Zhixiong Liu and Quan Cheng

    Citation: Journal of Translational Medicine 2020 18:368

    Content type: Correction

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    The original article was published in Journal of Translational Medicine 2020 18:305

  37. The existence of active crosstalk between cells in a paracrine and juxtacrine manner dictates specific activity under physiological and pathological conditions. Upon juxtacrine interaction between the cells, v...

    Authors: Hesam Saghaei Bagheri, Farhad Bani, Savas Tasoglu, Amir Zarebkohan, Reza Rahbarghazi and Emel Sokullu

    Citation: Journal of Translational Medicine 2020 18:367

    Content type: Review

    Published on:

  38. Pregnant women with gestational diabetes mellitus (GDM) or type 2 diabetes mellitus (T2DM) are at increased risks of pre-term labor, hypertension and preeclampsia. In this study, metabolic profiling of blood s...

    Authors: Ilhame Diboun, Manjunath Ramanjaneya, Yasser Majeed, Lina Ahmed, Mohammed Bashir, Alexandra E. Butler, Abdul Badi Abou-Samra, Stephen L. Atkin, Nayef A. Mazloum and Mohamed A. Elrayess

    Citation: Journal of Translational Medicine 2020 18:366

    Content type: Research

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  39. Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a serious and complex physical illness that affects all body systems with a multiplicity of symptoms, but key hallmarks of the disease are pervasi...

    Authors: Eiren Sweetman, Torsten Kleffmann, Christina Edgar, Michel de Lange, Rosamund Vallings and Warren Tate

    Citation: Journal of Translational Medicine 2020 18:365

    Content type: Research

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  40. Adoptive transfer of engineered immune cells is a promising strategy for cancer treatment. However, low transduction efficiency particularly when large payload lentiviral vectors are used on primary T cells is...

    Authors: Lingyu Li, Yuan Gao, Richa Srivastava, Wei Wang, Qinghui Xiong, Zhiming Fang, Alejandra Pelayo, Carolyn Denson, Angshumala Goswami, Rona Harari-Steinfeld, Zhifen Yang, Lihong Weng, Lei Stanley Qi and Francesco M. Marincola

    Citation: Journal of Translational Medicine 2020 18:363

    Content type: Research

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  41. Since the first outbreak of SARS-CoV-2, the clinical characteristics of the Coronavirus Disease 2019 (COVID-19) have been progressively changed. Data reporting a viral intra-host and inter-host evolution favou...

    Authors: Francesca Caccuri, Alberto Zani, Serena Messali, Marta Giovanetti, Antonella Bugatti, Giovanni Campisi, Federica Filippini, Erika Scaltriti, Massimo Ciccozzi, Simona Fiorentini and Arnaldo Caruso

    Citation: Journal of Translational Medicine 2020 18:362

    Content type: Research

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  42. Extracellular vesicles (ECV) and bone extracellular matrix (ECM) have beneficial effects on the treatment of some pathological conditions. The purpose of this study was to find the synergic effects of decellul...

    Authors: Asrin Emami, Tahereh Talaei-Khozani, Saeid Tavanafar, Nehleh Zareifard, Negar Azarpira and Zahra Vojdani

    Citation: Journal of Translational Medicine 2020 18:361

    Content type: Research

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  43. Cancer stem cells (CSCs) are crucial to the malignant behaviour and poor prognosis of pancreatic ductal adenocarcinoma (PDAC). In recent years, CSC biology has been widely studied, but practical prognostic sig...

    Authors: Zengyu Feng, Minmin Shi, Kexian Li, Yang Ma, Lingxi Jiang, Hao Chen and Chenghong Peng

    Citation: Journal of Translational Medicine 2020 18:360

    Content type: Research

    Published on:

  44. More than seven months into the coronavirus disease -19 (COVID-19) pandemic, infection from the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has led to over 21.2 million cases and resulted in o...

    Authors: Maurice A. Canham, John D. M. Campbell and Joanne C. Mountford

    Citation: Journal of Translational Medicine 2020 18:359

    Content type: Review

    Published on:

  45. COVID-19 caused by a novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) originated in Wuhan (Hubei province, China) during late 2019. It has spread across the globe affecting nearly 21 million ...

    Authors: Sina Salajegheh Tazerji, Phelipe Magalhães Duarte, Parastoo Rahimi, Fatemeh Shahabinejad, Santosh Dhakal, Yashpal Singh Malik, Awad A. Shehata, Juan Lama, Jörn Klein, Muhammad Safdar, Md. Tanvir Rahman, Krzysztof J. Filipiak, Alfonso J. Rodríguez-Morales, Md. Abdus Sobur, Farrokhreza Kabir, Bita Vazir…

    Citation: Journal of Translational Medicine 2020 18:358

    Content type: Review

    Published on:

  46. Epithelial ovarian cancer (EOC) is the most lethal disease among female genital malignant tumors. Peptidylarginine deiminase type II(PADI II) has been shown to enhance a variety of cancers carcinogenesis, incl...

    Authors: Lidong Liu, Zhiwei Zhang, Guoxiang Zhang, Ting Wang, Yingchun Ma and Wei Guo

    Citation: Journal of Translational Medicine 2020 18:357

    Content type: Research

    Published on:

  47. Spectrin repeat containing nuclear envelope family member 3 (SYNE3) encodes an essential component of the linker of the cytoskeleton and nucleoskeleton (LINC) complex, namely nesprin-3. In a tumor, invasivenes...

    Authors: Liwei Liao, Longshan Zhang, Mi Yang, Xiaoqing Wang, Weiqiang Huang, Xixi Wu, Hua Pan, Lu Yuan, Wenqi Huang, Yuting Wu and Jian Guan

    Citation: Journal of Translational Medicine 2020 18:355

    Content type: Research

    Published on:

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