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Cancer microenvironment

Section edited by Davide Bedognetti

The Cancer microenvironment section publishes research on the cellular and molecular components of the cancer microenvironment, with a particular focus on translational research that has important implications for the prevention, diagnosis and treatment of human neoplasms.

Submissions that relate to the characterisation of the molecular profile and regulation of cancers at different tumour stages are especially welcome, as are those which identify specific cancer microenvironments that predict tumour incidence, response to therapy and outcome. Laboratory studies of new drugs and biological agents that target cancer microenvironments will also be considered.

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  1. Content type: Research

    Incomplete thermal ablation may induce invasiveness of hepatocellular carcinoma (HCC). Here, we investigated whether activated hepatic stellate cells (HSCs) would accelerate the progression of residual HCC aft...

    Authors: Rui Zhang, Xia-Hui Lin, Min Ma, Jie Chen, Jun Chen, Dong-Mei Gao, Jie-Feng Cui and Rong-Xin Chen

    Citation: Journal of Translational Medicine 2018 16:302

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  2. Content type: Research

    Hepatocyte growth factor (HGF) plays a pivotal role in breast cancer cell motility, invasion and angiogenesis. These pro-metastatic events are triggered through HGF coupling and activation of the c-Met recepto...

    Authors: Christian Parr and Ahmed Y. Ali

    Citation: Journal of Translational Medicine 2018 16:281

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  3. Content type: Research

    The mainstay of treatment of advanced ovarian cancer (AOC) involves chemotherapy, and debulking surgery. However, despite optimal surgical procedure and adjuvant chemotherapy, 60% of patients with AOC will rel...

    Authors: Jennifer Pasquier, Fabien Vidal, Jessica Hoarau-Véchot, Claire Bonneau, Emile Daraï, Cyril Touboul and Arash Rafii

    Citation: Journal of Translational Medicine 2018 16:271

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  4. Content type: Research

    Approximately half of the documented increases in differentiated thyroid carcinoma is due to identification of papillary thyroid microcarcinomas (PTMCs). Knowing whether PTMC is aggressive is required for prop...

    Authors: Jianlu Song, Shouxin Wu, Xiaotian Xia, Yu Wang, Youben Fan and Zhili Yang

    Citation: Journal of Translational Medicine 2018 16:269

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  5. Content type: Research

    The American Joint Committee on Cancer has recently revised the tumor-node-metastasis (TNM) staging system on thyroid cancer, which illustrated that the cut-off age for predicting mortality has elevated from 4...

    Authors: Weiheng Wen, Peili Wu, Jitong Li, He Wang, Jia Sun and Hong Chen

    Citation: Journal of Translational Medicine 2018 16:261

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  6. Content type: Research

    Hyaluronan (HA), a major component of the extracellular matrix, has been proven to play a crucial role in tumor progression. However, it remains unknown whether HA exerts any effects in myelodysplastic syndrom...

    Authors: Cheng-Ming Fei, Juan Guo, You-Shan Zhao, Si-Da Zhao, Qing-Qing Zhen, Lei Shi, Xiao Li and Chun-Kang Chang

    Citation: Journal of Translational Medicine 2018 16:234

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  7. Content type: Research

    Multiple myeloma (MM) is a cancer of terminally differentiated plasma that is part of a spectrum of blood diseases. The role of the micro-environment is crucial for MM clonal evolution.

    Authors: Angelina Boccarelli, Flavia Esposito, Mauro Coluccia, Maria Antonia Frassanito, Angelo Vacca and Nicoletta Del Buono

    Citation: Journal of Translational Medicine 2018 16:217

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  8. Content type: Research

    Currently, mismatch repair-deficient (dMMR) status is a promising candidate for targeted immune checkpoint inhibition therapy in colorectal cancer (CRC) patients, however, the potential immunological mechanism...

    Authors: Shou-Sheng Liu, Yuan-Zhong Yang, Chang Jiang, Qi Quan, Qian-Kun Xie, Xiao-Pai Wang, Wen-Zhuo He, Yu-Ming Rong, Ping Chen, Qiong Yang, Lin Yang, Bei Zhang, Xiao-Jun Xia, Peng-Fei Kong and Liang-Ping Xia

    Citation: Journal of Translational Medicine 2018 16:195

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  9. Content type: Research

    Vimentin (VIM) is a type III intermediate filament that maintains cell integrity, and is involved in cell migration, motility and adhesion. When overexpressed in solid cancers, vimentin drives epithelial to me...

    Authors: Sharon Wu, Yang Du, John Beckford and Houda Alachkar

    Citation: Journal of Translational Medicine 2018 16:170

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  10. Content type: Research

    Hypoxia-mediated chemoresistance has been regarded as an important obstacle in the development of cancer treatment. Knockdown of krüppel-like factor 5 (KLF5) was reported to inhibit hypoxia-induced cell surviv...

    Authors: Tianxiao Gong, Liuqing Cui, Haili Wang, Haoxun Wang and Na Han

    Citation: Journal of Translational Medicine 2018 16:164

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  11. Content type: Research

    Tumor-promoting inflammation is an emerging hallmark of cancer, which participates in both cancer progression and immune escape. Hepatocellular carcinoma (HCC) is a typical inflammation-related cancer with an ...

    Authors: Chun Xu, Xian Lu, Wei Liu, Anxian Chen, Gang Meng, Hailin Zhang, Binghua Li, Yonghui Zhang, Junhua Wu and Jiwu Wei

    Citation: Journal of Translational Medicine 2018 16:132

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  12. Content type: Review

    It has been reported mesenchymal stem cells (MSCs) are recruited to and become integral parts of the tumor microenvironment. MSCs might have an active role in solid tumor progression, especially cancer metasta...

    Authors: Jing-Huan Li, Wen-Shuai Fan, Mi-Mi Wang, Yan-Hong Wang and Zheng-Gang Ren

    Citation: Journal of Translational Medicine 2018 16:113

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  13. Content type: Review

    Cisplatin is a widely used chemotherapeutic agent for treatment of various cancers. However, treatment with cisplatin is associated with drug resistance and several adverse side effects such as nephrotoxicity,...

    Authors: Iman W. Achkar, Nabeel Abdulrahman, Hend Al-Sulaiti, Jensa Mariam Joseph, Shahab Uddin and Fatima Mraiche

    Citation: Journal of Translational Medicine 2018 16:96

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  14. Content type: Research

    Stromal gene expression patterns predict patient outcomes in colorectal cancer. TRIM28 is a transcriptional co-repressor that regulates an abundance of genes through the KRAB domain family of transcription fac...

    Authors: Seán Fitzgerald, Virginia Espina, Lance Liotta, Katherine M. Sheehan, Anthony O’Grady, Robert Cummins, Richard O’Kennedy, Elaine W. Kay and Gregor S. Kijanka

    Citation: Journal of Translational Medicine 2018 16:89

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  15. Content type: Research

    The trastuzumab, pertuzumab, and docetaxel (TPD) regimen is strongly recommended as a treatment option for first-line therapy for advanced human epidermal growth factor receptor (HER) 2-positive breast cancer....

    Authors: Koji Takada, Shinichiro Kashiwagi, Wataru Goto, Yuka Asano, Katsuyuki Takahashi, Tsutomu Takashima, Shuhei Tomita, Masahiko Ohsawa, Kosei Hirakawa and Masaichi Ohira

    Citation: Journal of Translational Medicine 2018 16:86

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  16. Content type: Research

    Recently, the concepts of progression due to pre-existing lesions (PPL) and progression due to new metastasis (PNM) have been proposed to differentiate the progression types of treatment-resistant cancers. Pre...

    Authors: Shinichiro Kashiwagi, Gen Tsujio, Yuka Asano, Wataru Goto, Koji Takada, Katsuyuki Takahashi, Tamami Morisaki, Hisakazu Fujita, Tsutomu Takashima, Shuhei Tomita, Masahiko Ohsawa, Kosei Hirakawa and Masaichi Ohira

    Citation: Journal of Translational Medicine 2018 16:54

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  17. Content type: Research

    CD133 is a marker of stem cells as well cancer stem cells. This study investigated the association between CD133 expression in cancer cells and the clinical outcome of non-mucin producing intrahepatic cholangi...

    Authors: Xiaobo Cai, Jun Li, Xiaodong Yuan, Jingbo Xiao, Steven Dooley, Xinjian Wan, Honglei Weng and Lungen Lu

    Citation: Journal of Translational Medicine 2018 16:50

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  18. Content type: Research

    Esophageal carcinoma is the eighth prevalent malignancy and ranks the sixth in carcinoma-related death worldwide. Tumor necrosis factor-α-induced protein-8 like-2 (TIPE2) has been identified as a tumor suppres...

    Authors: Linan Zhu, Xudong Zhang, Xiaorui Fu, Zhaoming Li, Zhenchang Sun, Jingjing Wu, Xinhua Wang, Feng Wang, Xiangke Li, Songtao Niu, Mengjie Ding, Zhenzhen Yang, Wanqiu Yang, Meifeng Yin, Lei Zhang and Mingzhi Zhang

    Citation: Journal of Translational Medicine 2018 16:7

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  19. Content type: Research

    Prostate cancer (PCa) is a complex disorder resulting from the combined effects of multiple environmental and genetic factors. Small non-coding RNAs (sRNAs), particularly microRNAs (miRNAs), regulate several c...

    Authors: Jingxuan Shan, Khalid Al-Rumaihi, Karim Chouchane, Issam Al-Bozom, Danny Rabah, Karim Farhat and Lotfi Chouchane

    Citation: Journal of Translational Medicine 2017 15:260

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  20. Content type: Research

    Metastasis is a major threat to colorectal cancer (CRC) patients. We have reported that peroxiredoxin-2 (PRDX2) is associated with CRC invasion and metastasis. However, the mechanisms regulating PRDX2 expressi...

    Authors: Zhenbing Lv, Jinlai Wei, Wenxian You, Rong Wang, Jingkun Shang, Yongfu Xiong, Hua Yang, Xuanhua Yang and Zhongxue Fu

    Citation: Journal of Translational Medicine 2017 15:257

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  21. Content type: Research

    Studies investigating the oxygenation status and the development of hypoxia in microscopic tumors are sparse. The purpose of this study was to measure the extent of hypoxia in microscopic melanoma xenografts a...

    Authors: Jon-Vidar Gaustad, Trude G. Simonsen, Lise Mari K. Andersen and Einar K. Rofstad

    Citation: Journal of Translational Medicine 2017 15:241

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  22. Content type: Research

    Intrahepatic cholangiocarcinoma (ICC) is an aggressive tumor with a high fatality rate. It was recently found that parathyroid hormone-like hormone (PTHLH) was frequently overexpressed in ICC compared with non...

    Authors: Jing Tang, Yan Liao, Shuying He, Jie Shi, Liang Peng, Xiaoping Xu, Fang Xie, Na Diao, Jinlan Huang, Qian Xie, Chuang Lin, Xiaoying Luo, Kaili Liao, Juanjuan Ma, Jingyi Li, Daichao Zhou…

    Citation: Journal of Translational Medicine 2017 15:238

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  23. Content type: Review

    The use of patient-derived primary cell cultures in cancer preclinical assays has increased in recent years. The management of resected tumor tissue remains complex and a number of parameters must be respected...

    Authors: Giacomo Miserocchi, Laura Mercatali, Chiara Liverani, Alessandro De Vita, Chiara Spadazzi, Federica Pieri, Alberto Bongiovanni, Federica Recine, Dino Amadori and Toni Ibrahim

    Citation: Journal of Translational Medicine 2017 15:229

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  24. Content type: Research

    Abnormalities in the tumor microenvironment are associated with resistance to treatment, aggressive growth, and poor clinical outcome in patients with advanced cervical cancer. The potential of dynamic contras...

    Authors: Anette Hauge, Catherine S. Wegner, Jon-Vidar Gaustad, Trude G. Simonsen, Lise Mari K. Andersen and Einar K. Rofstad

    Citation: Journal of Translational Medicine 2017 15:225

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  25. Content type: Research

    There is increasing evidence that the existence of systemic inflammation response is correlated with poor prognosis in several solid tumors. The aim of this retrospective study was to investigate the associati...

    Authors: Yu-Suo Tong, Juan Tan, Xi-Lei Zhou, Ya-Qi Song and Ying-Jian Song

    Citation: Journal of Translational Medicine 2017 15:221

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  26. Content type: Meeting report

    The predictive accuracy of the traditional staging system is based on disease progression as a tumour cell-autonomous process, but it fails to incorporate the effects of the host immune response. A precise ana...

    Authors: Jerome Galon, Alessandro Lugli, Carlo Bifulco, Franck Pages, Giuseppe Masucci, Francesco M. Marincola and Paolo A. Ascierto

    Citation: Journal of Translational Medicine 2017 15:212

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  27. Content type: Research

    Autophagy is a highly regulated biological process that mediates the degradation of intracellular components. It is required for tumor cell metabolism and homeostasis. Yin-Yang 1 (YY1) has been reported to be ...

    Authors: Chuang Yang, Jing-Jing Zhang, Yun-Peng Peng, Yi Zhu, Ling-Di Yin, Ji-Shu Wei, Wen-Tao Gao, Kui-Rong Jiang and Yi Miao

    Citation: Journal of Translational Medicine 2017 15:211

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  28. Content type: Research

    The mitochondrial protein p32 is a validated therapeutic target of cancer overexpressed in glioma. Therapeutic targeting of p32 with monoclonal antibody or p32-binding LyP-1 tumor-homing peptide can limit tumo...

    Authors: Venkata Yenugonda, Natsuko Nomura, Valentina Kouznetsova, Igor Tsigelny, Valentina Fogal, Elmar Nurmemmedov, Santosh Kesari and Ivan Babic

    Citation: Journal of Translational Medicine 2017 15:210

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  29. Content type: Research

    Extracellular acidosis is a condition found within the tumor microenvironment due to inadequate blood perfusion, hypoxia, and altered tumor cell metabolism. Acidosis has pleiotropic effects on malignant progre...

    Authors: Calvin R. Justus, Edward J. Sanderlin, Lixue Dong, Tianai Sun, Jen-Tsan Chi, Kvin Lertpiriyapong and Li V. Yang

    Citation: Journal of Translational Medicine 2017 15:204

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  30. Content type: Research

    Malignant melanoma of the skin can metastasize through blood vessels and lymphatics. The primary tumor develops a vascular microenvironment characterized by abnormal blood vessels and lymphatics and a physicoc...

    Authors: Ruixia Huang, Lise Mari K. Andersen and Einar K. Rofstad

    Citation: Journal of Translational Medicine 2017 15:203

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  31. Content type: Research

    Glioblastoma (GBM) is a highly aggressive primary brain cancer, for which curative therapies are not available. An emerging therapeutic approach suggested to have potential to target malignant gliomas has been...

    Authors: Joana Vieira de Castro, Eduardo D. Gomes, Sara Granja, Sandra I. Anjo, Fátima Baltazar, Bruno Manadas, António J. Salgado and Bruno M. Costa

    Citation: Journal of Translational Medicine 2017 15:200

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  32. Content type: Meeting report

    SLFN11 is a recently discovered protein with a putative DNA/RNA helicase function. First identified in association with the maturation of thymocytes, SLFN11 was later causally associated, by two independent gr...

    Authors: Alberto Ballestrero, Davide Bedognetti, Domenico Ferraioli, Paola Franceschelli, Sana Intidhar Labidi-Galy, Elisabetta Leo, Junko Murai, Yves Pommier, Petros Tsantoulis, Valerio Gaetano Vellone and Gabriele Zoppoli

    Citation: Journal of Translational Medicine 2017 15:199

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  33. Content type: Research

    In order to improve therapy for head and neck squamous cell carcinoma (HNSCC), biomarkers associated with local and/or distant tumor relapses and cancer drug resistance are urgently needed. This study identifi...

    Authors: Shutong Liu, Bo Ren, Hang Gao, Suchan Liao, Ying-Xian Zhai, Shirong Li, Xue-Jin Su, Ping Jin, David Stroncek, Zhixiang Xu, Qinghua Zeng and Yulin Li

    Citation: Journal of Translational Medicine 2017 15:189

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  34. Content type: Research

    Hepatocellular carcinoma (HCC) is one of the most lethal cancers worldwide owing to its high rates of metastasis and recurrence. The oncogene IQ motif-containing GTPase activating protein 3 (IQGAP3) is ubiquitous...

    Authors: Yongjie Shi, Nan Qin, Qiang Zhou, Yanqiu Chen, Sicong Huang, Bo Chen, Gang Shen and Hongyun Jia

    Citation: Journal of Translational Medicine 2017 15:176

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  35. Content type: Research

    The coiled-coil domain is a structural motif found in proteins that participate in a variety of biological processes. Aberrant expression of such proteins has been shown to be associated with the malignant beh...

    Authors: Ran Xu, Mingzhi Han, Yangyang Xu, Xin Zhang, Chao Zhang, Di Zhang, Jianxiong Ji, Yuzhen Wei, Shuai Wang, Bin Huang, Anjing Chen, Qing Zhang, Wenjie Li, Tao Sun, Feng Wang, Xingang Li…

    Citation: Journal of Translational Medicine 2017 15:165

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  36. Content type: Research

    Dendritic cells (DC) and tumour-associated macrophages (TAM) are essential in linking the innate and adaptive immune response against tumour cells and tumour progression. These cells are also potential target ...

    Authors: Sebastian Lundgren, Emelie Karnevi, Jacob Elebro, Björn Nodin, Mikael C. I. Karlsson, Jakob Eberhard, Karin Leandersson and Karin Jirström

    Citation: Journal of Translational Medicine 2017 15:152

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  37. Content type: Research

    The interaction of vascular endothelial growth factor-C (VEGF-C)/VEGF-D/VEGF receptor-3 is considered to be a major driver of lymphangiogenesis, however the mechanism of this process remains unclear. We aimed ...

    Authors: Haruhisa Kitano, Joon-Yong Chung, Kyung Hee Noh, Young-Ho Lee, Tae Woo Kim, Seok Hyung Lee, Soo-Heang Eo, Hyung Jun Cho, Chel Hun Choi, Shuhei Inoue, Jun Hanaoka, Junya Fukuoka and Stephen M. Hewitt

    Citation: Journal of Translational Medicine 2017 15:138

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  38. Content type: Research

    Shikonin, a natural naphthoquinone pigment purified from Lithospermum erythrorhizon, induces necroptosis in various cancer types, but the mechanisms underlying the anticancer activity of shikonin in lung cancer a...

    Authors: Hyo-Jin Kim, Ki-Eun Hwang, Do-Sim Park, Seon-Hee Oh, Hong Young Jun, Kwon-Ha Yoon, Eun-Taik Jeong, Hak-Ryul Kim and Young-Suk Kim

    Citation: Journal of Translational Medicine 2017 15:123

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  39. Content type: Research

    Imatinib causes increased turnover of stromal collagen, reduces collagen fibril diameter, enhances extracellular fluid turnover and lowers interstitial fluid pressure (IFP) in the human colonic carcinoma KAT-4...

    Authors: Mikhail Burmakin, Tijs van Wieringen, P. Olof Olsson, Linda Stuhr, Aive Åhgren, Carl-Henrik Heldin, Rolf K. Reed, Kristofer Rubin and Carina Hellberg

    Citation: Journal of Translational Medicine 2017 15:47

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  40. Content type: Research

    In a previously reported study, patients with regionally advanced melanoma were treated with neoadjuvant ipilimumab (ipi) (Tarhini in PLoS ONE 9(2): e87705, 3). Significant changes in circulating myeloid derived...

    Authors: Yana G. Najjar, Fei Ding, Yan Lin, Robert VanderWeele, Lisa H. Butterfield and Ahmad A. Tarhini

    Citation: Journal of Translational Medicine 2017 15:39

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  41. Content type: Research

    The robust desmoplasia associated with head and neck squamous cell carcinoma (HNSCC) suggests that the tumor microenvironment may be an important component in the pathophysiology of this cancer. Moreover, the ...

    Authors: Tammara L. Watts, Ruwen Cui, Peter Szaniszlo, Vicente A. Resto, Don W. Powell and Irina V. Pinchuk

    Citation: Journal of Translational Medicine 2016 14:337

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  42. Content type: Research

    Non-Hodgkin lymphomas (NHL) are the most frequent hemato-oncological malignancies. Despite recent major advances in treatment, a substantial proportion of patients relapses highlighting the need for new therap...

    Authors: Thais Bascuas, María Moreno, Amy Mónaco, Laura Reyes, Andrea Paolino, Patricia Oliver, María G. Kramer, Henry Engler, José P. Pacheco, Sofía Grille and José A. Chabalgoity

    Citation: Journal of Translational Medicine 2016 14:323

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  43. Content type: Research

    E-cadherin is a major component of adherens junctions that regulates cell shape and maintains tissue integrity. A complete loss or any decrease in cell surface expression of E-cadherin will interfere with the ...

    Authors: Hager Memni, Yosra Macherki, Zahra Klayech, Ahlem Ben-Haj-Ayed, Karim Farhat, Yassmine Remadi, Sallouha Gabbouj, Wijden Mahfoudh, Nadia Bouzid, Noureddine Bouaouina, Lotfi Chouchane, Abdelfattah Zakhama and Elham Hassen

    Citation: Journal of Translational Medicine 2016 14:320

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  44. Content type: Research

    In recent years, immunomodulatory mechanisms of mesenchymal stem/stromal cells (MSCs) from bone marrow and other “classic” sources have been described. However, the phenotypic and functional properties of tumo...

    Authors: María de Lourdes Mora-García, Rosario García-Rocha, Omar Morales-Ramírez, Juan José Montesinos, Benny Weiss-Steider, Jorge Hernández-Montes, Luis Roberto Ávila-Ibarra, Christian Azucena Don-López, Marco Antonio Velasco-Velázquez, Vianey Gutiérrez-Serrano and Alberto Monroy-García

    Citation: Journal of Translational Medicine 2016 14:302

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  45. Content type: Research

    Age has been reported as an independent prognostic factor for melanoma-specific survival (MSS). We tested the hypothesis that age impacts the host anti-tumor immune response, accounting for age-specific surviv...

    Authors: Sarah A. Weiss, Joseph Han, Farbod Darvishian, Jeremy Tchack, Sung Won Han, Karolina Malecek, Michelle Krogsgaard, Iman Osman and Judy Zhong

    Citation: Journal of Translational Medicine 2016 14:299

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  46. Content type: Review

    Tumor microenvironment (TME) plays an integral part in the biology of cancer, participating in tumor initiation, progression, and response to therapy. Exosome is an important part of TME. Exosomes are small ve...

    Authors: Zhen Wang, Jun-Qiang Chen, Jin-lu Liu and Lei Tian

    Citation: Journal of Translational Medicine 2016 14:297

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  47. Content type: Research

    Several cellular functions relate to ion-channels activity. Physiologically relevant chains of events leading to angiogenesis, cell cycle and different forms of cell death, require transmembrane voltage contro...

    Authors: Antonella Biasiotta, Daniela D’Arcangelo, Francesca Passarelli, Ezio Maria Nicodemi and Antonio Facchiano

    Citation: Journal of Translational Medicine 2016 14:285

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  48. Content type: Research

    Molecular subtypes of breast cancer and presence of tumor-infiltrating immune cells have both been implicated as important predictive and prognostic factors for improved risk stratification and treatment indiv...

    Authors: M. Miyan, J. Schmidt-Mende, R. Kiessling, I. Poschke and J. de Boniface

    Citation: Journal of Translational Medicine 2016 14:227

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  49. Content type: Research

    Acquired radioresistance during radiotherapy is considered as the most important reason for local tumor recurrence or treatment failure. Circular RNAs (circRNAs) have recently been identified as microRNA spong...

    Authors: Huafang Su, Fuqiang Lin, Xia Deng, Lanxiao Shen, Ya Fang, Zhenghua Fei, Lihao Zhao, Xuebang Zhang, Huanle Pan, Deyao Xie, Xiance Jin and Congying Xie

    Citation: Journal of Translational Medicine 2016 14:225

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