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Cancer Microenvironment

Section edited by Davide Bedognetti

© © nopparit / Getty Images / iStock

The Cancer microenvironment section publishes research on the cellular and molecular components of the cancer microenvironment, with a particular focus on translational research that has important implications for the prevention, diagnosis and treatment of human neoplasms.

Submissions that relate to the characterisation of the molecular profile and regulation of cancers at different tumour stages are especially welcome, as are those which identify specific cancer microenvironments that predict tumour incidence, response to therapy and outcome. Laboratory studies of new drugs and biological agents that target cancer microenvironments will also be considered.

Featured articles


microRNA-1271 impedes the development of prostate cancer by downregulating PES1 and upregulating ERβ

Research | Zhenming Jiang et al


Tumor microenvironment differences between primary tumor and brain metastases

Review | Bernardo Cacho-Díaz et al


Identification of key genes controlling breast cancer stem cell characteristics via stemness indices analysis

Research | Jianying Pei et al

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  1. Necroptosis is a new form of programmed cell death that is associated with cancer initiation, progression, immunity, and chemoresistance. However, the roles of necroptosis-related genes (NRGs) in colorectal ca...

    Authors: Wenqin Luo, Wenqiang Xiang, Lu Gan, Ji Che, Jing Li, Yichao Wang, Lingyu Han, Ruiqi Gu, Li Ye, Renjie Wang, Xiuping Zhang, Ye Xu, Weixing Dai, Shaobo Mo, Qingguo Li and Guoxiang Cai
    Citation: Journal of Translational Medicine 2022 20:235
  2. Little is known about SARS-CoV-2 seroconversion in asymptomatic patients affected by solid cancer, and whether it is associated with specific transcriptomics changes in peripheral blood mononuclear cells (PBMC).

    Authors: Francesco Ravera, Roberto Borea, Gabriella Cirmena, Martina Dameri, Lorenzo Ferrando, Maurizio Gallo, Cecilia Casini, Neri Fallani, Mario Stabile, Valentina Barbero, Roberto Murialdo, Lucia Tixi, Margherita Cappuccio, Andrea Cuboni, Irene Sivieri, Giuseppe Fornarini…
    Citation: Journal of Translational Medicine 2022 20:230
  3. Colorectal cancer is a commonly diagnosed cancer worldwide. Unfortunately, many patients do not respond to standard chemotherapy treatments and develop disease relapse and metastases. Besides cancer cell speci...

    Authors: Simona Salerno, Anders Ståhlberg, André Holdfeldt, Elinor Bexe Lindskog and Göran Landberg
    Citation: Journal of Translational Medicine 2022 20:209
  4. The establishing of the first cancer models created a new perspective on the identification and evaluation of new anti-cancer therapies in preclinical studies. Patient-derived xenograft models are created by t...

    Authors: Shahrokh Abdolahi, Zeinab Ghazvinian, Samad Muhammadnejad, Mahshid Saleh, Hamid Asadzadeh Aghdaei and Kaveh Baghaei
    Citation: Journal of Translational Medicine 2022 20:206
  5. As a common complication of epithelial ovarian cancer (EOC), malignant ascites contributes to the peritoneal metastasis of EOC. CircRNAs play essential roles in tumor metastasis. However, no circRNAs have been...

    Authors: Ning Luo, Zubaidan Sulaiman, Chunyan Wang, Jinye Ding, Yingying Chen, Biting Liu, Zhongping Cheng and Shupeng Liu
    Citation: Journal of Translational Medicine 2022 20:201
  6. N6-methyladenosine (m6A) RNA methylation plays a critical role in key genetic events for various cancers; yet, how m6A functions within the tumor microenvironment (TME) remains to be elucidated.

    Authors: Yuzhen Gao, Hao Wang, Shipeng Chen, Rui An, Yadong Chu, Guoli Li, Yanzhong Wang, Xinyou Xie and Jun Zhang
    Citation: Journal of Translational Medicine 2022 20:197
  7. Cholangiocarcinoma (CCA) refers to an aggressive malignancy with a high fatality rate and poor prognosis. Globally, the morbidity of CCA is increasing for the past few decades, which has progressed into a dise...

    Authors: Kai Zhao, Xiangyu Li, Yuanxin Shi, Yun Lu, Peng Qiu, Zhengdong Deng, Wei Yao and Jianming Wang
    Citation: Journal of Translational Medicine 2022 20:117
  8. Exosomal miRNAs have attracted much attention due to their critical role in regulating genes and the altered expression of miRNAs in virtually all cancers affecting humans (Sun et al. in Mol Cancer 17(1):14, 2...

    Authors: Chuanyun Li, Tong Zhou, Jing Chen, Rong Li, Huan Chen, Shumin Luo, Dexi Chen, Cao Cai and Weihua Li
    Citation: Journal of Translational Medicine 2022 20:6
  9. Cancer-associated fibroblasts (CAFs), the most abundant cells in the tumor microenvironment, have prominent roles in the development of solid tumors as stromal targets. However, the underlying mechanism of CAF...

    Authors: Jia-Yi Zhang, Wei-Wen Zhu, Meng-Yao Wang, Run-Dong Zhai, Qiong Wang, Wei-Li Shen and Lai-Kui Liu
    Citation: Journal of Translational Medicine 2021 19:513
  10. Immunotherapies targeting ligand-receptor interactions (LRIs) are advancing rapidly in the treatment of colorectal cancer (CRC), and LRIs also affect many aspects of CRC development. However, the pattern of LR...

    Authors: Hexin Lin, Lu Xia, Jiabian Lian, Yinan Chen, Yiyi Zhang, Zhicheng Zhuang, HuaJun Cai, Jun You and Guoxian Guan
    Citation: Journal of Translational Medicine 2021 19:497
  11. The characterization of the immune component of the tumor microenvironment (TME) of human epidermal growth factor receptor 2 positive (HER2+) breast cancer has been limited. Molecular and spatial characterizat...

    Authors: Ilana Schlam, Sarah E. Church, Tyler D. Hether, Krysta Chaldekas, Briana M. Hudson, Andrew M. White, Emily Maisonet, Brent T. Harris and Sandra M. Swain
    Citation: Journal of Translational Medicine 2021 19:480
  12. The diversity and plasticity behind ER+/PR−/HER2− breast cancer have not been widely explored. It is essential to identify heterogeneous microenvironment phenotypes and investigate specific genomic events driv...

    Authors: Peiling Xie, Rui An, Shibo Yu, Jianjun He and Huimin Zhang
    Citation: Journal of Translational Medicine 2021 19:398
  13. Tumor heterogeneity is a primary cause of treatment failure. However, changes in drug sensitivity over time are not well mapped in cancer. Patient-derived organoids (PDOs) may predict clinical drug responses e...

    Authors: Kushtrim Kryeziu, Seyed H. Moosavi, Christian H. Bergsland, Marianne G. Guren, Peter W. Eide, Max Z. Totland, Kristoffer Lassen, Andreas Abildgaard, Arild Nesbakken, Anita Sveen and Ragnhild A. Lothe
    Citation: Journal of Translational Medicine 2021 19:384
  14. Antiangiogenic therapy has increasingly become an important strategy for the treatment of colorectal cancer. Recent studies have shown that the tumour microenvironment (TME) promotes tumour angiogenesis. Bufal...

    Authors: Kai Fang, Yueping Zhan, Ruiqiu Zhu, Yuqian Wang, Chengqi Wu, Min Sun, Yanyan Qiu, Zeting Yuan, Xin Liang, Peihao Yin and Ke Xu
    Citation: Journal of Translational Medicine 2021 19:383
  15. Tumor-derived exosomes (TEXs) are involved in tumor progression and the immune modulation process and mediate intercellular communication in the tumor microenvironment. Although exosomes are considered promisi...

    Authors: Jiani Wu, Dongqiang Zeng, Shimeng Zhi, Zilan Ye, Wenjun Qiu, Na Huang, Li Sun, Chunlin Wang, Zhenzhen Wu, Jianping Bin, Yulin Liao, Min Shi and Wangjun Liao
    Citation: Journal of Translational Medicine 2021 19:381
  16. Since interferon regulatory factor (IRF) family functions in immune response to viral infection, its role in colorectal cancer (CRC) has not been inspected before. This study tries to investigate members of IR...

    Authors: Yan-Jie Chen, Shu-Neng Luo, Ling Dong, Tao-Tao Liu, Xi-Zhong Shen, Ning-Ping Zhang and Li Liang
    Citation: Journal of Translational Medicine 2021 19:379
  17. Accumulative evidence shows that an organoid is a more practical and reliable tool in cancer biology research. This study aimed to identify and validate crucial genes involved in non-small cell lung cancer car...

    Authors: Xiao Ma, Su Yang, Hesheng Jiang, Yujie Wang and Zhen Xiang
    Citation: Journal of Translational Medicine 2021 19:368
  18. Fine tuned balance of reactive oxygen species (ROS) is essential for tumor cells and tumor cells use immune checkpoints to evade attack form immunity system. However, it’s unclear whether there is any crosstal...

    Authors: Bangbao Tao, Juanhong Shi, Shuai Shuai, Haiyan Zhou, Hongxia Zhang, Bin Li, Xiaoqiang Wang, Guohui Li, Hua He and Jun Zhong
    Citation: Journal of Translational Medicine 2021 19:338
  19. Lung cancer is the leading cause of cancer-associated deaths accounting for 24% of all cancer deaths. As a crucial phase of tumor progression, lung cancer metastasis is linked to over 70% of these mortalities....

    Authors: Lei Yin, Xiaotian Liu, Xuejun Shao, Tao Feng, Jun Xu, Qi Wang and Shenghao Hua
    Citation: Journal of Translational Medicine 2021 19:312
  20. This is the first study to build and evaluate a predictive model for early relapse after R0 resection in hepatocellular carcinoma (HCC) patients with microvascular invasion (MVI).

    Authors: Kai Zhang, Changcheng Tao, Tana Siqin, Jianxiong Wu and Weiqi Rong
    Citation: Journal of Translational Medicine 2021 19:293
  21. Long non-coding RNA (lncRNA) maternally expressed gene 3 (MEG3) has been implicated in the progression of esophageal cancer (EC). However, the specific mechanism of the involvement of MEG3 in EC development in...

    Authors: Qi-Rong Xu, Jian Tang, Hong-Ying Liao, Ben-Tong Yu, Xiang-Yuan He, Yu-Zhen Zheng and Sheng Liu
    Citation: Journal of Translational Medicine 2021 19:264
  22. Soft-tissue sarcomas (STS) are a heterogeneous group of mesenchymal tumors for which response to immunotherapies is not well established. Therefore, it is important to risk-stratify and identify STS patients w...

    Authors: Malte Simon, Sadaf S. Mughal, Peter Horak, Sebastian Uhrig, Jonas Buchloh, Bogac Aybey, Albrecht Stenzinger, Hanno Glimm, Stefan Fröhling, Benedikt Brors and Charles D. Imbusch
    Citation: Journal of Translational Medicine 2021 19:204

    The Correction to this article has been published in Journal of Translational Medicine 2022 20:152

  23. Growing attention have been paid to the relationship between TP53 and tumor immunophenotype, but there are still lacking enough search on the field of gastric cancer (GC).

    Authors: Junyu Huo, Liqun Wu and Yunjin Zang
    Citation: Journal of Translational Medicine 2021 19:183
  24. Patient-derived xenografts established from human cancers are important tools for investigating novel anti-cancer therapies. Establishing PDXs requires a significant investment and many PDXs may be used infreq...

    Authors: Lindsey Abel, Arda Durmaz, Rong Hu, Colin Longhurst, Andrew M. Baschnagel, Deric Wheeler, Jacob G. Scott and Randall J. Kimple
    Citation: Journal of Translational Medicine 2021 19:180
  25. As part of the 2020 Immunotherapy Bridge virtual congress (December 2nd–3rd, Italy), the Great Debate session featured counterpoint views from leading experts on three clinical questions in immunotherapy today...

    Authors: Paolo A. Ascierto, Joshua Brody, Lisa H. Butterfield, Olivera J. Finn, John Goldberg, Francesco Perrone, Ryan J. Sullivan, Bernard A. Fox, Patrick Hwu and Igor Puzanov
    Citation: Journal of Translational Medicine 2021 19:144
  26. Tumor invasiveness reflects many biological changes associated with tumorigenesis, progression, metastasis, and drug resistance. Therefore, we performed a systematic assessment of invasiveness-related molecula...

    Authors: Guoshu Bi, Jiaqi Liang, Yuansheng Zheng, Runmei Li, Mengnan Zhao, Yiwei Huang, Cheng Zhan, Songtao Xu and Hong Fan
    Citation: Journal of Translational Medicine 2021 19:124
  27. Glioma, the most common primary brain tumor, account Preparing figures for 30 to 40% of all intracranial tumors. Herein, we aimed to study the effects of M2 macrophage-derived exosomal microRNAs (miRNAs) on gl...

    Authors: Jie Yao, Zefen Wang, Yong Cheng, Chao Ma, Yahua Zhong, Yilei Xiao, Xu Gao and Zhiqiang Li
    Citation: Journal of Translational Medicine 2021 19:99

    The Correction to this article has been published in Journal of Translational Medicine 2021 19:263

  28. Adult granulosa cell tumor (aGCT) is a rare type of stromal cell malignant cancer of the ovary characterized by elevated estrogen levels. aGCTs ubiquitously harbor a somatic mutation in FOXL2 gene, Cys134Trp (c.4...

    Authors: Christian Secchi, Paola Benaglio, Francesca Mulas, Martina Belli, Dwayne Stupack and Shunichi Shimasaki
    Citation: Journal of Translational Medicine 2021 19:90
  29. Tumor mutation burden (TMB) has been associated with melanoma immunotherapy (IT) outcomes, including survival. We explored whether combining TMB with immunogenomic signatures recently identified by The Cancer ...

    Authors: Leah Morales, Danny Simpson, Robert Ferguson, John Cadley, Eduardo Esteva, Kelsey Monson, Vylyny Chat, Carlos Martinez, Jeffrey Weber, Iman Osman and Tomas Kirchhoff
    Citation: Journal of Translational Medicine 2021 19:78
  30. One of the most prevalent causes of fetal hypoxia leading to stillbirth is placental insufficiency. Hemodynamic changes evaluated with Doppler ultrasound have been used as a surrogate marker of fetal hypoxia. ...

    Authors: Laura Pla, Sergio Berdún, Mònica Mir, Lourders Rivas, Sandrine Miserere, Samuel Dulay, Josep Samitier, Elisenda Eixarch, Miriam Illa and Eduard Gratacós
    Citation: Journal of Translational Medicine 2021 19:53

    The Letter to the Editor to this article has been published in Journal of Translational Medicine 2021 19:252

  31. Current diagnostic blood tests for prostate cancer (PCa) are unreliable for the early stage disease, resulting in numerous unnecessary prostate biopsies in men with benign disease and false reassurance of nega...

    Authors: Heba Alshaker, Robert Mills, Ewan Hunter, Matthew Salter, Aroul Ramadass, Benjamin Matthew Skinner, Willem Westra, Jayne Green, Alexandre Akoulitchev, Mathias Winkler and Dmitri Pchejetski
    Citation: Journal of Translational Medicine 2021 19:46
  32. KRAS gene is the most common type of mutation reported in colorectal cancer (CRC). KRAS mutation-mediated regulation of immunophenotype and immune pathways in CRC remains to be elucidated.

    Authors: Jungang Liu, Xiaoliang Huang, Haizhou Liu, Chunyin Wei, Haiming Ru, Haiquan Qin, Hao Lai, Yongsheng Meng, Guo Wu, Weishun Xie, Xianwei Mo, Caroline H. Johnson, Yawei Zhang and Weizhong Tang
    Citation: Journal of Translational Medicine 2021 19:27
  33. Metastatic breast cancer (mBC) is a complex and life-threatening disease and although it is difficult to cure, patients can benefit from sequential anticancer treatment, including endocrine therapy, targeted t...

    Authors: Seongyeong Kim, Dongjin Shin, Ahrum Min, Minjung Kim, Deukchae Na, Han-Byeol Lee, Han Suk Ryu, Yaewon Yang, Go-Un Woo, Kyung-Hun Lee, Dae-Won Lee, Tae-Yong Kim, Charles Lee, Seock-Ah Im and Jong-Il Kim
    Citation: Journal of Translational Medicine 2021 19:7
  34. Mammary carcinogenesis is partly regulated by the transforming growth factor beta (TGFβ) signaling pathway. Its function in cancer progression and metastasis is highly dependent on disease stage, and it is lik...

    Authors: Lovorka Grgurevic, Ruder Novak, Vladimir Trkulja, Stela Hrkac, Grgur Salai, Josko Bilandzic, Lejla Ferhatovic Hamzic, Ivan Milas, Tiha Vucemilo, Melita Peric Balja and Karmen Bilic
    Citation: Journal of Translational Medicine 2020 18:478
  35. Interleukin-33 (IL-33) is an effective inducer of pro-inflammatory cytokines regulating innate and adaptive immunity. Inflammation could be a double-edged sword, promoting or inhibiting tumour growth. To date,...

    Authors: Wenxiu Wang, Jun Wu, Mei Ji and Changping Wu
    Citation: Journal of Translational Medicine 2020 18:477
  36. The outcomes of immune checkpoint inhibitors in cancer patients with liver metastases are poor, which may be related to a different tumor microenvironment in liver metastases from primary tumors. This study wa...

    Authors: Xiao-Li Wei, Xuan Luo, Hui Sheng, Yun Wang, Dong-Liang Chen, Jia-Ning Li, Feng-Hua Wang and Rui-Hua Xu
    Citation: Journal of Translational Medicine 2020 18:475
  37. The solid tumor microenvironment possesses a hypoxic condition, which promotes aggressiveness and resistance to therapies. Hypoxic tumor cells undergo broadly metabolic and molecular adaptations and communicat...

    Authors: Reza Jafari, Reza Rahbarghazi, Mahdi Ahmadi, Mehdi Hassanpour and Jafar Rezaie
    Citation: Journal of Translational Medicine 2020 18:474
  38. Heparanase is the only mammalian enzyme that cleaves heparan sulphate, an important component of the extracellular matrix. This leads to the remodelling of the extracellular matrix, whilst liberating growth fa...

    Authors: Krishnath M. Jayatilleke and Mark D. Hulett
    Citation: Journal of Translational Medicine 2020 18:453
  39. The tumor microenvironment (TME) is a critical player in tumor progression, metastasis and therapy outcomes. Tumor-associated macrophages (TAMs) are a well-recognized core element of the TME and generally char...

    Authors: Ilseon Hwang, Jeong Won Kim, Kris Ylaya, Eun Joo Chung, Haruhisa Kitano, Candice Perry, Jun Hanaoka, Junya Fukuoka, Joon-Yong Chung and Stephen M. Hewitt
    Citation: Journal of Translational Medicine 2020 18:443
  40. Breast cancer is a highly heterogeneous disease, this poses challenges for classification and management. Long non-coding RNAs play acrucial role in the breast cancersdevelopment and progression, especially in...

    Authors: Wei Ma, Fangkun Zhao, Xinmiao Yu, Shu Guan, Huandan Suo, Zuo Tao, Yue Qiu, Yunfei Wu, Yu Cao and Feng Jin
    Citation: Journal of Translational Medicine 2020 18:442
  41. Poly(ADP-ribose) polymerase inhibitors (PARPis) specifically target homologous recombination deficiency (HRD) cells and display good therapeutic effect in women with advanced-stage BRCA1/2-mutated breast and e...

    Authors: Razan Sheta, Magdalena Bachvarova, Marie Plante, Marie-Claude Renaud, Alexandra Sebastianelli, Jean Gregoire, Jamilet Miranda Navarro, Ricardo Bringas Perez, Jean-Yves Masson and Dimcho Bachvarov
    Citation: Journal of Translational Medicine 2020 18:439
  42. Accumulating evidence has demonstrated that immune-related lncRNAs (IRLs) are commonly aberrantly expressed in breast cancer (BC). Thus, we aimed to establish an IRL-based tool to improve prognosis prediction ...

    Authors: Jianguo Lai, Bo Chen, Guochun Zhang, Xuerui Li, Hsiaopei Mok and Ning Liao
    Citation: Journal of Translational Medicine 2020 18:416
  43. Cancer Associated Macrophage-Like cells (CAMLs) are polynucleated circulating stromal cells found in the bloodstream of numerous solid-tumor malignancies. Variations within CAML size have been associated with ...

    Authors: Daniel J. Gironda, Daniel L. Adams, Jianzhong He, Ting Xu, Hui Gao, Yawei Qiao, Ritsuko Komaki, James M. Reuben, Zhongxing Liao, Mariela Blum-Murphy, Wayne L. Hofstetter, Cha-Mei Tang and Steven H. Lin
    Citation: Journal of Translational Medicine 2020 18:413
  44. Methyltransferase-like 3 (METTL3) is a member of the m6A methyltransferase family and acts as an oncogene in cancers. Recent studies suggest that host innate immunity is regulated by the enzymes controlling m6A e...

    Authors: Huan-he Ni, Lin Zhang, He Huang, Shu-qin Dai and Jiang Li
    Citation: Journal of Translational Medicine 2020 18:393

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