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Cancer Microenvironment

Section edited by Davide Bedognetti

© © nopparit / Getty Images / iStock

The Cancer microenvironment section publishes research on the cellular and molecular components of the cancer microenvironment, with a particular focus on translational research that has important implications for the prevention, diagnosis and treatment of human neoplasms.

Submissions that relate to the characterisation of the molecular profile and regulation of cancers at different tumour stages are especially welcome, as are those which identify specific cancer microenvironments that predict tumour incidence, response to therapy and outcome. Laboratory studies of new drugs and biological agents that target cancer microenvironments will also be considered.

Featured articles


microRNA-1271 impedes the development of prostate cancer by downregulating PES1 and upregulating ERβ

Research | Zhenming Jiang et al


Tumor microenvironment differences between primary tumor and brain metastases

Review | Bernardo Cacho-Díaz et al


Identification of key genes controlling breast cancer stem cell characteristics via stemness indices analysis

Research | Jianying Pei et al

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  1. As part of the 2020 Immunotherapy Bridge virtual congress (December 2nd–3rd, Italy), the Great Debate session featured counterpoint views from leading experts on three clinical questions in immunotherapy today...

    Authors: Paolo A. Ascierto, Joshua Brody, Lisa H. Butterfield, Olivera J. Finn, John Goldberg, Francesco Perrone, Ryan J. Sullivan, Bernard A. Fox, Patrick Hwu and Igor Puzanov

    Citation: Journal of Translational Medicine 2021 19:144

    Content type: Meeting report

    Published on:

  2. Tumor invasiveness reflects many biological changes associated with tumorigenesis, progression, metastasis, and drug resistance. Therefore, we performed a systematic assessment of invasiveness-related molecula...

    Authors: Guoshu Bi, Jiaqi Liang, Yuansheng Zheng, Runmei Li, Mengnan Zhao, Yiwei Huang, Cheng Zhan, Songtao Xu and Hong Fan

    Citation: Journal of Translational Medicine 2021 19:124

    Content type: Research

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  3. Glioma, the most common primary brain tumor, account Preparing figures for 30 to 40% of all intracranial tumors. Herein, we aimed to study the effects of M2 macrophage-derived exosomal microRNAs (miRNAs) on gl...

    Authors: Jie Yao, Zefen Wang, Yong Cheng, Chao Ma, Yahua Zhong, Yilei Xiao, Xu Gao and Zhiqiang Li

    Citation: Journal of Translational Medicine 2021 19:99

    Content type: Research

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  4. Adult granulosa cell tumor (aGCT) is a rare type of stromal cell malignant cancer of the ovary characterized by elevated estrogen levels. aGCTs ubiquitously harbor a somatic mutation in FOXL2 gene, Cys134Trp (c.4...

    Authors: Christian Secchi, Paola Benaglio, Francesca Mulas, Martina Belli, Dwayne Stupack and Shunichi Shimasaki

    Citation: Journal of Translational Medicine 2021 19:90

    Content type: Research

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  5. Tumor mutation burden (TMB) has been associated with melanoma immunotherapy (IT) outcomes, including survival. We explored whether combining TMB with immunogenomic signatures recently identified by The Cancer ...

    Authors: Leah Morales, Danny Simpson, Robert Ferguson, John Cadley, Eduardo Esteva, Kelsey Monson, Vylyny Chat, Carlos Martinez, Jeffrey Weber, Iman Osman and Tomas Kirchhoff

    Citation: Journal of Translational Medicine 2021 19:78

    Content type: Research

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  6. One of the most prevalent causes of fetal hypoxia leading to stillbirth is placental insufficiency. Hemodynamic changes evaluated with Doppler ultrasound have been used as a surrogate marker of fetal hypoxia. ...

    Authors: Laura Pla, Sergio Berdún, Mònica Mir, Lourders Rivas, Sandrine Miserere, Samuel Dulay, Josep Samitier, Elisenda Eixarch, Miriam Illa and Eduard Gratacós

    Citation: Journal of Translational Medicine 2021 19:53

    Content type: Research

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  7. Current diagnostic blood tests for prostate cancer (PCa) are unreliable for the early stage disease, resulting in numerous unnecessary prostate biopsies in men with benign disease and false reassurance of nega...

    Authors: Heba Alshaker, Robert Mills, Ewan Hunter, Matthew Salter, Aroul Ramadass, Benjamin Matthew Skinner, Willem Westra, Jayne Green, Alexandre Akoulitchev, Mathias Winkler and Dmitri Pchejetski

    Citation: Journal of Translational Medicine 2021 19:46

    Content type: Research

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  8. KRAS gene is the most common type of mutation reported in colorectal cancer (CRC). KRAS mutation-mediated regulation of immunophenotype and immune pathways in CRC remains to be elucidated.

    Authors: Jungang Liu, Xiaoliang Huang, Haizhou Liu, Chunyin Wei, Haiming Ru, Haiquan Qin, Hao Lai, Yongsheng Meng, Guo Wu, Weishun Xie, Xianwei Mo, Caroline H. Johnson, Yawei Zhang and Weizhong Tang

    Citation: Journal of Translational Medicine 2021 19:27

    Content type: Research

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  9. Metastatic breast cancer (mBC) is a complex and life-threatening disease and although it is difficult to cure, patients can benefit from sequential anticancer treatment, including endocrine therapy, targeted t...

    Authors: Seongyeong Kim, Dongjin Shin, Ahrum Min, Minjung Kim, Deukchae Na, Han-Byeol Lee, Han Suk Ryu, Yaewon Yang, Go-Un Woo, Kyung-Hun Lee, Dae-Won Lee, Tae-Yong Kim, Charles Lee, Seock-Ah Im and Jong-Il Kim

    Citation: Journal of Translational Medicine 2021 19:7

    Content type: Research

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  10. Mammary carcinogenesis is partly regulated by the transforming growth factor beta (TGFβ) signaling pathway. Its function in cancer progression and metastasis is highly dependent on disease stage, and it is lik...

    Authors: Lovorka Grgurevic, Ruder Novak, Vladimir Trkulja, Stela Hrkac, Grgur Salai, Josko Bilandzic, Lejla Ferhatovic Hamzic, Ivan Milas, Tiha Vucemilo, Melita Peric Balja and Karmen Bilic

    Citation: Journal of Translational Medicine 2020 18:478

    Content type: Research

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  11. Interleukin-33 (IL-33) is an effective inducer of pro-inflammatory cytokines regulating innate and adaptive immunity. Inflammation could be a double-edged sword, promoting or inhibiting tumour growth. To date,...

    Authors: Wenxiu Wang, Jun Wu, Mei Ji and Changping Wu

    Citation: Journal of Translational Medicine 2020 18:477

    Content type: Research

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  12. The outcomes of immune checkpoint inhibitors in cancer patients with liver metastases are poor, which may be related to a different tumor microenvironment in liver metastases from primary tumors. This study wa...

    Authors: Xiao-Li Wei, Xuan Luo, Hui Sheng, Yun Wang, Dong-Liang Chen, Jia-Ning Li, Feng-Hua Wang and Rui-Hua Xu

    Citation: Journal of Translational Medicine 2020 18:475

    Content type: Research

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  13. The solid tumor microenvironment possesses a hypoxic condition, which promotes aggressiveness and resistance to therapies. Hypoxic tumor cells undergo broadly metabolic and molecular adaptations and communicat...

    Authors: Reza Jafari, Reza Rahbarghazi, Mahdi Ahmadi, Mehdi Hassanpour and Jafar Rezaie

    Citation: Journal of Translational Medicine 2020 18:474

    Content type: Review

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  14. Heparanase is the only mammalian enzyme that cleaves heparan sulphate, an important component of the extracellular matrix. This leads to the remodelling of the extracellular matrix, whilst liberating growth fa...

    Authors: Krishnath M. Jayatilleke and Mark D. Hulett

    Citation: Journal of Translational Medicine 2020 18:453

    Content type: Review

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  15. The tumor microenvironment (TME) is a critical player in tumor progression, metastasis and therapy outcomes. Tumor-associated macrophages (TAMs) are a well-recognized core element of the TME and generally char...

    Authors: Ilseon Hwang, Jeong Won Kim, Kris Ylaya, Eun Joo Chung, Haruhisa Kitano, Candice Perry, Jun Hanaoka, Junya Fukuoka, Joon-Yong Chung and Stephen M. Hewitt

    Citation: Journal of Translational Medicine 2020 18:443

    Content type: Research

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  16. Breast cancer is a highly heterogeneous disease, this poses challenges for classification and management. Long non-coding RNAs play acrucial role in the breast cancersdevelopment and progression, especially in...

    Authors: Wei Ma, Fangkun Zhao, Xinmiao Yu, Shu Guan, Huandan Suo, Zuo Tao, Yue Qiu, Yunfei Wu, Yu Cao and Feng Jin

    Citation: Journal of Translational Medicine 2020 18:442

    Content type: Research

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  17. Poly(ADP-ribose) polymerase inhibitors (PARPis) specifically target homologous recombination deficiency (HRD) cells and display good therapeutic effect in women with advanced-stage BRCA1/2-mutated breast and e...

    Authors: Razan Sheta, Magdalena Bachvarova, Marie Plante, Marie-Claude Renaud, Alexandra Sebastianelli, Jean Gregoire, Jamilet Miranda Navarro, Ricardo Bringas Perez, Jean-Yves Masson and Dimcho Bachvarov

    Citation: Journal of Translational Medicine 2020 18:439

    Content type: Research

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  18. Accumulating evidence has demonstrated that immune-related lncRNAs (IRLs) are commonly aberrantly expressed in breast cancer (BC). Thus, we aimed to establish an IRL-based tool to improve prognosis prediction ...

    Authors: Jianguo Lai, Bo Chen, Guochun Zhang, Xuerui Li, Hsiaopei Mok and Ning Liao

    Citation: Journal of Translational Medicine 2020 18:416

    Content type: Research

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  19. Cancer Associated Macrophage-Like cells (CAMLs) are polynucleated circulating stromal cells found in the bloodstream of numerous solid-tumor malignancies. Variations within CAML size have been associated with ...

    Authors: Daniel J. Gironda, Daniel L. Adams, Jianzhong He, Ting Xu, Hui Gao, Yawei Qiao, Ritsuko Komaki, James M. Reuben, Zhongxing Liao, Mariela Blum-Murphy, Wayne L. Hofstetter, Cha-Mei Tang and Steven H. Lin

    Citation: Journal of Translational Medicine 2020 18:413

    Content type: Research

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  20. Methyltransferase-like 3 (METTL3) is a member of the m6A methyltransferase family and acts as an oncogene in cancers. Recent studies suggest that host innate immunity is regulated by the enzymes controlling m6A e...

    Authors: Huan-he Ni, Lin Zhang, He Huang, Shu-qin Dai and Jiang Li

    Citation: Journal of Translational Medicine 2020 18:393

    Content type: Research

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  21. The non-classical human leukocyte antigen (HLA)-G is a strong immunomodulatory molecule. Under physiological conditions, HLA-G induces immunological tolerance in immune privileged tissues, while under pathophy...

    Authors: Michael Friedrich, Christine Stoehr, Simon Jasinski-Bergner, Arndt Hartmann, Sven Wach, Bernd Wullich, André Steven and Barbara Seliger

    Citation: Journal of Translational Medicine 2020 18:371

    Content type: Research

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  22. Cancer stem cells (CSCs) are crucial to the malignant behaviour and poor prognosis of pancreatic ductal adenocarcinoma (PDAC). In recent years, CSC biology has been widely studied, but practical prognostic sig...

    Authors: Zengyu Feng, Minmin Shi, Kexian Li, Yang Ma, Lingxi Jiang, Hao Chen and Chenghong Peng

    Citation: Journal of Translational Medicine 2020 18:360

    Content type: Research

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  23. Epithelial ovarian cancer (EOC) is the most lethal disease among female genital malignant tumors. Peptidylarginine deiminase type II(PADI II) has been shown to enhance a variety of cancers carcinogenesis, incl...

    Authors: Lidong Liu, Zhiwei Zhang, Guoxiang Zhang, Ting Wang, Yingchun Ma and Wei Guo

    Citation: Journal of Translational Medicine 2020 18:357

    Content type: Research

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  24. Distal cholangiocarcinoma is an aggressive malignancy with a dismal prognosis. Diagnostic and prognostic biomarkers for distal cholangiocarcinoma are lacking. The aim of the present study was to identify diffe...

    Authors: Johannes Byrling, Theresa Kristl, Dingyuan Hu, Indira Pla, Aniel Sanchez, Agata Sasor, Roland Andersson, György Marko-Varga and Bodil Andersson

    Citation: Journal of Translational Medicine 2020 18:343

    Content type: Research

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  25. Hypoxia plays an indispensable role in the development of hepatocellular carcinoma (HCC). However, there are few studies on the application of hypoxia molecules in the prognosis predicting of HCC. We aim to id...

    Authors: Baohui Zhang, Bufu Tang, Jianyao Gao, Jiatong Li, Lingming Kong and Ling Qin

    Citation: Journal of Translational Medicine 2020 18:342

    Content type: Research

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  26. Malignant pleural mesothelioma (MPM) is an aggressive neoplasm of the pleura, mainly related to asbestos exposure. As in other solid tumors, malignant cells exhibit high glucose uptake and glycolytic rates wit...

    Authors: Irene Dell’Anno, Elisa Barone, Luciano Mutti, Doris M. Rassl, Stefan J. Marciniak, Roberto Silvestri, Stefano Landi and Federica Gemignani

    Citation: Journal of Translational Medicine 2020 18:341

    Content type: Research

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  27. Duodenal adenocarcinoma (DA) is a rare yet aggressive malignancy, with increasing incidence in the last decades. Its low frequency has hampered a thorough understanding of the pathogenesis of the disease and o...

    Authors: G. Donisi, G. Capretti, N. Cortese, A. Rigamonti, F. Gavazzi, G. Nappo, A. Pulvirenti, M. Sollai, P. Spaggiari, A. Zerbi and F. Marchesi

    Citation: Journal of Translational Medicine 2020 18:340

    Content type: Research

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  28. Immune-related genes (IRGs) have been confirmed to have an important role in tumorigenesis and tumor microenvironment formation. Nevertheless, a systematic analysis of IRGs and their clinical significance in s...

    Authors: Chuan Hu, Bo Chen, Zhangheng Huang, Chuan Liu, Lin Ye, Cailin Wang, Yuexin Tong, Jiaxin Yang and Chengliang Zhao

    Citation: Journal of Translational Medicine 2020 18:337

    Content type: Research

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  29. African American women experience a twofold higher incidence of triple-negative breast cancer (TNBC) and are 40% more likely to die from breast cancer than women of other ethnicities. However, the molecular ba...

    Authors: Xuan Yang, Mohamed Amgad, Lee A. D. Cooper, Yuhong Du, Haian Fu and Andrey A. Ivanov

    Citation: Journal of Translational Medicine 2020 18:334

    Content type: Research

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  30. Recently, it has been reported that miRNA is involved in pterygium, however the exact underlying mechanism in pterygium is unrevealed and require further investigation.

    Authors: Siying He, Yifang Huang, Shiqi Dong, Chen Qiao, Guohua Yang, Shuai Zhang, Chen Wang, Yuting Xu, Fang Zheng and Ming Yan

    Citation: Journal of Translational Medicine 2020 18:332

    Content type: Research

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  31. Colon cancer is a disease with high malignancy and incidence in the world. Tumor immune microenvironment (TIM) and tumor mutational burden (TMB) have been proved to play crucial roles in predicting clinical ou...

    Authors: Xinyi Wang, Jinzhong Duanmu, Xiaorui Fu, Taiyuan Li and Qunguang Jiang

    Citation: Journal of Translational Medicine 2020 18:324

    Content type: Research

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  32. Treatment of human lung squamous cell carcinoma (LUSC) using current targeted therapies is limited because of their diverse somatic mutations without any specific dominant driver mutations. These mutational di...

    Authors: Hae-Yun Jung, Tae Ho Kim, Jong-Eun Lee, Hong Kwan Kim, Jong Ho Cho, Yong Soo Choi, Sumin Shin, Se-Hoon Lee, Hwanseok Rhee, Hee Kyung Lee, Hyun Jung Choi, Hye Yoon Jang, Seungjae Lee, Jung Hee Kang, Young Ae Choi, Sanghyuk Lee…

    Citation: Journal of Translational Medicine 2020 18:307

    Content type: Research

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  33. Immunotherapies targeting glioblastoma (GBM) have led to significant improvements in patient outcomes. TOX is closely associated with the immune environment surrounding tumors, but its role in gliomas is not f...

    Authors: Hao Zhang, Fan Fan, Yuanqiang Yu, Zeyu Wang, Fangkun Liu, Ziyu Dai, Liyang Zhang, Zhixiong Liu and Quan Cheng

    Citation: Journal of Translational Medicine 2020 18:305

    Content type: Research

    Published on:

    The Correction to this article has been published in Journal of Translational Medicine 2020 18:368

  34. Bladder cancer (BlCa) taxonomy has proved its impact in patient outcome and selection for targeted therapies, but such transcriptomic-based classification has not yet translated to routine practice. Moreover, ...

    Authors: João Lobo, Sara Monteiro-Reis, Catarina Guimarães-Teixeira, Paula Lopes, Isa Carneiro, Carmen Jerónimo and Rui Henrique

    Citation: Journal of Translational Medicine 2020 18:303

    Content type: Research

    Published on:

  35. The tumor immune microenvironment is a heterogeneous entity. Gene expression analysis allows us to perform comprehensive immunoprofiling and may assist in dissecting the different components of the immune infi...

    Authors: W. S. M. E. Theelen, O. Krijgsman, K. Monkhorst, T. Kuilman, D. D. G. C. Peters, S. Cornelissen, M. A. Ligtenberg, S. M. Willems, J. L. G. Blaauwgeers, C. J. M. van Noesel, D. S. Peeper, M. M. van den Heuvel and K. Schulze

    Citation: Journal of Translational Medicine 2020 18:271

    Content type: Research

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  36. Few studies have delved into the prevalence of distant metastasis (DM +) and survival for patients with lymph node metastases (LN +) by primary site. We aimed to detect differences in distant metastasis and pr...

    Authors: Xin Lou, Jun Li, Ya-Qing Wei, Zhi-Jia Jiang, Ming Chen and Jin-Jin Sun

    Citation: Journal of Translational Medicine 2020 18:266

    Content type: Research

    Published on:

  37. Patient-derived xenograft (PDX) mouse models of cancer have been recognized as better mouse models that recapitulate the characteristics of original malignancies including preserved tumor heterogeneity, lineag...

    Authors: Zhenyang Liu, Michael Ho-Young Ahn, Tomohiro Kurokawa, Amy Ly, Gong Zhang, Fuyou Wang, Teppei Yamada, Ananthan Sadagopan, Jane Cheng, Cristina R. Ferrone, Andrew S. Liss, Kim C. Honselmann, Gregory R. Wojtkiewicz, Soldano Ferrone and Xinhui Wang

    Citation: Journal of Translational Medicine 2020 18:255

    Content type: Research

    Published on:

  38. Although oropharyngeal squamous cell carcinoma (OPSCC) with human papillomavirus (HPV) infection has a good prognosis, the accurate prediction of survival and risk of treatment failure is essential to design d...

    Authors: Soohyeon Kwon, Soon-Hyun Ahn, Woo-Jin Jeong, Young Ho Jung, Yun Jung Bae, Jin Ho Paik, Jin-Haeng Chung and Hyojin Kim

    Citation: Journal of Translational Medicine 2020 18:240

    Content type: Research

    Published on:

  39. Cancer-related mortality in patients with colorectal cancer (CRC) is predominantly caused by development of colorectal liver metastases (CLMs). How to screen the sensitive chemotherapy and targeted therapy is ...

    Authors: Mi Jian, Li Ren, Guodong He, Qi Lin, Wentao Tang, Yijiao Chen, Jingwen Chen, Tianyu Liu, Meiling Ji, Ye Wei, Wenju Chang and Jianmin Xu

    Citation: Journal of Translational Medicine 2020 18:234

    Content type: Research

    Published on:

  40. As a nucleolar protein associated with ribosome biogenesis, pescadillo homolog 1 (PES1) has been reported to participate in the development of many cancers. However, its role in prostate cancer is not clearly ...

    Authors: Zhenming Jiang, Yuxi Zhang, Xi Chen, Yan Wang, Pingeng Wu, Chengzhang Wu and Dong Chen

    Citation: Journal of Translational Medicine 2020 18:209

    Content type: Research

    Published on:

  41. Patients with metastatic uveal melanoma (MUM) in the liver usually die within 1 year. The development of new treatments for MUM has been limited by the lack of diverse MUM cell lines and appropriate animal mod...

    Authors: Takahito Sugase, Bao Q. Lam, Meggie Danielson, Mizue Terai, Andrew E. Aplin, J. Silvio Gutkind and Takami Sato

    Citation: Journal of Translational Medicine 2020 18:208

    Content type: Research

    Published on:

  42. Most tumors develop abnormal fibrotic regions consisting of fibroblasts, immune cells, and a dense extracellular matrix (ECM) immersed in a viscous interstitial fluid, and an abundant fibrotic tumor microenvir...

    Authors: Anette Hauge and Einar K. Rofstad

    Citation: Journal of Translational Medicine 2020 18:207

    Content type: Review

    Published on:

  43. Increasing evidences have found that the clinical importance of the interaction between hypoxia and immune status in gastric cancer microenvironment. However, reliable prognostic signatures based on combinatio...

    Authors: Yifan Liu, Jianhua Wu, Weiwei Huang, Shaowen Weng, Baochun Wang, Yiming Chen and Hao Wang

    Citation: Journal of Translational Medicine 2020 18:201

    Content type: Research

    Published on:

  44. Osteosarcoma is a highly metastatic primary bone tumor that predominantly affects adolescents and young adults. A mainstay of treatment in osteosarcoma is removal of the primary tumor. However, surgical excisi...

    Authors: Michelle P. Kallis, Caroline Maloney, Brandon Blank, Samuel Z. Soffer, Marc Symons and Bettie M. Steinberg

    Citation: Journal of Translational Medicine 2020 18:183

    Content type: Research

    Published on:

  45. Systemic inflammatory response in colorectal cancer (CRC) has been established as a prognostic factor for impaired cancer-specific survival, predominantly in patients with right-sided tumors. On the other hand...

    Authors: Ulf Gunnarsson, Karin Strigård, Sofia Edin, Ioannis Gkekas, Harri Mustonen, Tuomas Kaprio, Camilla Böckelman, Jaana Hagström, Richard Palmqvist and Caj Haglund

    Citation: Journal of Translational Medicine 2020 18:178

    Content type: Research

    Published on:

  46. Prostate cancer (PCa) is one of the most prevalent cancers that occur in men worldwide. Autophagy-related genes (ARGs) may play an essential role in multiple biological processes of prostate cancer. However, A...

    Authors: Daixing Hu, Li Jiang, Shengjun Luo, Xin Zhao, Hao Hu, Guozhi Zhao and Wei Tang

    Citation: Journal of Translational Medicine 2020 18:160

    Content type: Research

    Published on:

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