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Cardiovascular, metabolic and Lipoprotein translation

Section edited by Nehal N. Mehta

This section aims to speed mechanistic understanding, development of novel diagnostics and potential therapeutic targets within cardiovascular, metabolic diseases and lipoprotein diseases. The section is open to experiments involving cellular models, animal models, observational studies and clinical trials that are distinguished for their novelty in approach, design or indication, timeliness, and unique ability to translate laboratory concepts from the bench to the bedside.

Highest priority will be given to those manuscripts which are specifically focused on cardiovascular, metabolic and lipid disorders which enrich understanding of disease mechanism, novel therapeutics and state-of-the-art scientific technique.

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  1. Content type: Research

    Conotruncal heart defect (CTD) is a complex congenital heart disease with a complex and poorly understood etiology. The transcriptional corepressor RIPPLY3 plays a pivotal role in heart development as a negati...

    Authors: Nanchao Hong, Erge Zhang, Qingjie Wang, Xiaoqing Zhang, Fen Li, Qihua Fu, Rang Xu, Yu Yu, Sun Chen, Yuejuan Xu and Kun Sun

    Citation: Journal of Translational Medicine 2018 16:260

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  2. Content type: Research

    Individuals with arterial hypertension often have an autonomic nervous system (ANS) imbalance with predominance of sympathetic ANS. This predominance can lead to injury of several organs affecting its function...

    Authors: Arthur F. Vale, Juliana A. Carneiro, Paulo C. V. Jardim, Thiago V. Jardim, James Steele, James P. Fisher and Paulo Gentil

    Citation: Journal of Translational Medicine 2018 16:240

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  3. Content type: Research

    Cardiomyopathies are the most common clinical and genetic heterogeneity cardiac diseases, and genetic contribution in particular plays a major role in patients with primary cardiomyopathies. The aim of this st...

    Authors: Chaoxia Lu, Wei Wu, Fang Liu, Kunqi Yang, Jiacheng Li, Yaping Liu, Rongrong Wang, Nuo Si, Peng Gao, Yongtai Liu, Shuyang Zhang and Xue Zhang

    Citation: Journal of Translational Medicine 2018 16:241

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  4. Content type: Research

    To explore the association between systolic and diastolic blood pressure (SBP and DBP respectively) and pulse pressure (PP) with cardiovascular disease (CVD) and mortality events among Iranian patients with pr...

    Authors: Ashkan Hashemi, Sormeh Nourbakhsh, Samaneh Asgari, Mohammadhassan Mirbolouk, Fereidoun Azizi and Farzad Hadaegh

    Citation: Journal of Translational Medicine 2018 16:230

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  5. Content type: Research

    YKL-40 (CHI3L1) is a novel biomarker for inflammation, tissue remodeling, and fibrosis, as well as cardiovascular diseases. We investigated the association between YKL-40 expression in epicardial adipose tissue (...

    Authors: Qing Wang, Hua Shen, Jie Min, Yang Gao, Kai Liu, Wang Xi, Jie Yang, Liang Yin, Jibin Xu, Jian Xiao and Zhinong Wang

    Citation: Journal of Translational Medicine 2018 16:229

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  6. Content type: Research

    The globally rising obesity epidemic is associated with a broad spectrum of diseases including atherosclerosis and non-alcoholic fatty liver (NAFL) disease. In the past, research focused on the vasculature or ...

    Authors: Erik Taylor, Nasi Huang, Jacob Bodde, Andrew Ellison, Ronald Killiany, Markus Michael Bachschmid and James Hamilton

    Citation: Journal of Translational Medicine 2018 16:215

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  7. Content type: Research

    MicroRNAs (miRNAs) are non-coding RNAs that function as regulators of gene expression and thereby contribute to the complex disease phenotypes. Hypertrophic cardiomyopathy (HCM) and Dilated cardiomyopathy (DCM...

    Authors: Mengmeng Li, Xiao Chen, Liang Chen, Kai Chen, Jianye Zhou and Jiangping Song

    Citation: Journal of Translational Medicine 2018 16:161

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  8. Content type: Research

    Scavenger receptor class B type I (SR-BI) plays a key role in high density lipoproteins (HDL) metabolism. SR-BI deficiency in mice results in enhanced susceptibility to atherosclerosis with abnormal large, cho...

    Authors: Jia Cao, Yanyong Xu, Feifei Li, Liang Shang, Daping Fan and Hong Yu

    Citation: Journal of Translational Medicine 2018 16:155

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  9. Content type: Research

    Discoidin domain receptor 1 (DDR1) is a collagen-activated receptor tyrosine kinase extensively implicated in diseases such as cancer, atherosclerosis and fibrosis. Multiple preclinical studies, performed usin...

    Authors: Solange Moll, Yukari Yasui, Ahmed Abed, Takeshi Murata, Hideaki Shimada, Akira Maeda, Naoshi Fukushima, Masakazu Kanamori, Sabine Uhles, Laura Badi, Thomas Cagarelli, Ivan Formentini, Faye Drawnel, Guy Georges, Tobias Bergauer, Rodolfo Gasser…

    Citation: Journal of Translational Medicine 2018 16:148

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  10. Content type: Research

    Oxidative stress has been linked to heart failure (HF) in humans. Antioxidant-based treatments are often ineffective. Therefore, we hypothesize that some of the HF patients might have a reductive stress (RS) c...

    Authors: Thiagarajan Sairam, Amit N. Patel, Meenu Subrahmanian, Rajendiran Gopalan, Steven M. Pogwizd, Sudha Ramalingam, Ramalingam Sankaran and Namakkal Soorapan Rajasekaran

    Citation: Journal of Translational Medicine 2018 16:130

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  11. Content type: Review

    The human immunodeficiency virus (HIV) is a major global public health issue. HIV-related cardiovascular disease remains a leading cause of morbidity and mortality in HIV positive patients. HIV Tat is a regula...

    Authors: Yanan Jiang, Lu Chai, Moyondafoluwa Blessing Fasae and Yunlong Bai

    Citation: Journal of Translational Medicine 2018 16:121

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  12. Content type: Research

    Preclinical and proof-of-concept studies suggest a cardioprotective effect of remote ischemic preconditioning (RIPC). However, two major clinical trials (ERICCA and RIPHeart) failed to show cardioprotection by...

    Authors: André Heinen, Friederike Behmenburg, Aykut Aytulun, Maximilian Dierkes, Lea Zerbin, Wolfgang Kaisers, Maximilian Schaefer, Tanja Meyer-Treschan, Susanne Feit, Inge Bauer, Markus W. Hollmann and Ragnar Huhn

    Citation: Journal of Translational Medicine 2018 16:112

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  13. Content type: Research

    The aim of this study was to characterize the influence of cardiopulmonary bypass (CPB) on myocardial remodeling in newborns and children.

    Authors: Johannes Petersen, Andrey Kazakov, Michael Böhm, Hans-Joachim Schäfers, Ulrich Laufs and Hashim Abdul-Khaliq

    Citation: Journal of Translational Medicine 2018 16:111

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  14. Content type: Research

    Intermittent hypoxia (IH), a typical character of obstructive sleep apnea (OSA), is related to atherogenesis. However, the role of IH on atherosclerosis (AS) progression and the mechanisms involved remains poo...

    Authors: Xianqin Zeng, Rong Guo, Mei Dong, Julia Zheng, Huili Lin and Huixia Lu

    Citation: Journal of Translational Medicine 2018 16:106

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  15. Content type: Research

    Perivascular adipose tissue (PVAT) accelerates plaque progression and increases cardiovascular risk. We tested the hypothesis that PVAT contributed to plaque vulnerability and investigated whether endoplasmic ...

    Authors: Ru Ying, Sheng-Wei Li, Jia-Yuan Chen, Hai-Feng Zhang, Ying Yang, Zhen-Jie Gu, Yang-Xin Chen and Jing-Feng Wang

    Citation: Journal of Translational Medicine 2018 16:105

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  16. Content type: Research

    Cardiovascular disease (CVD) describes the pathological conditions of the heart and blood vessels. Despite the large number of studies on CVD and its etiology, its key modulators remain largely unknown. To thi...

    Authors: Vasiliki Lygirou, Agnieszka Latosinska, Manousos Makridakis, William Mullen, Christian Delles, Joost P. Schanstra, Jerome Zoidakis, Burkert Pieske, Harald Mischak and Antonia Vlahou

    Citation: Journal of Translational Medicine 2018 16:104

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  17. Content type: Research

    MicroRNAs (miRNAs) are small RNAs regulating gene expression post-transcriptionally. While acquired changes of miRNA and mRNA profiles in cancer have been extensively studied, little is known about expression ...

    Authors: Masood Abu-Halima, Mustafa Kahraman, Dominic Henn, Tanja Rädle-Hurst, Andreas Keller, Hashim Abdul-Khaliq and Eckart Meese

    Citation: Journal of Translational Medicine 2018 16:60

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  18. Content type: Research

    There is a preponderance of evidence implicating diabetes with increased coronary artery disease (CAD) and calcification (CAC) in human patients with metabolic syndrome (MetS), but the effect of diabetes on CA...

    Authors: Jill K. Badin, Ayeeshik Kole, Benjamin Stivers, Victor Progar, Anisha Pareddy, Mouhamad Alloosh and Michael Sturek

    Citation: Journal of Translational Medicine 2018 16:58

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  19. Content type: Research

    Familial hypercholesterolemia (FH) is a genetic disorder that result in abnormally high low-density lipoprotein cholesterol levels, markedly increased risk of coronary heart disease (CHD) and tendon xanthomas ...

    Authors: Lucía Baila-Rueda, Itziar Lamiquiz-Moneo, Estíbaliz Jarauta, Rocío Mateo-Gallego, Sofía Perez-Calahorra, Victoria Marco-Benedí, Ana M. Bea, Ana Cenarro and Fernando Civeira

    Citation: Journal of Translational Medicine 2018 16:6

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  20. Content type: Research

    Metabolic syndrome (MetS) is a highly prevalent condition that identifies individuals at risk for type 2 diabetes mellitus and atherosclerotic cardiovascular disease. Prevention of these diseases relies on ear...

    Authors: Michelle D. Robinson, Ina Mishra, Sneha Deodhar, Vipulkumar Patel, Katrina V. Gordon, Raul Vintimilla, Kim Brown, Leigh Johnson, Sid O’Bryant and David P. Cistola

    Citation: Journal of Translational Medicine 2017 15:258

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  21. Content type: Review

    Spondylarthritis (SpA) is an inflammatory rheumatic disease associated with increased incidence of major adverse cardiovascular events (MACEs). Recently, Paramarta et al. proposed the use of the tyrosine kinas...

    Authors: Loukman Omarjee, Vincent Jaquinandi and Guillaume Mahe

    Citation: Journal of Translational Medicine 2017 15:255

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  22. Content type: Research

    Image-guided high intensity focused ultrasound has been used as an extracorporeal cardiac pacing tool and to enhance homing of stem cells to targeted tissues. However, molecular changes in the myocardium after...

    Authors: Kee W. Jang, Tsang-Wei Tu, Matthew E. Nagle, Bobbi K. Lewis, Scott R. Burks and Joseph A. Frank

    Citation: Journal of Translational Medicine 2017 15:252

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  23. Content type: Review

    GlycA is a novel spectroscopic marker of systemic inflammation with low intra-individual variability and other attributes favoring its clinical use in patients with chronic inflammatory and autoimmune diseases...

    Authors: Margery A. Connelly, James D. Otvos, Irina Shalaurova, Martin P. Playford and Nehal N. Mehta

    Citation: Journal of Translational Medicine 2017 15:219

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  24. Content type: Research

    Ex-vivo normothermic perfusion strategies are a promising new instrument in organ transplantation. The perfusion conditions are designed to be protective however the artificial environment can induce a local i...

    Authors: Sarah A. Hosgood, Tom Moore, Theresa Kleverlaan, Tom Adams and Michael L. Nicholson

    Citation: Journal of Translational Medicine 2017 15:216

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  25. Content type: Research

    Renal denervation (RDN) is a promising therapeutic method in cardiology. Its currently most investigated indication is resistant hypertension. Other potential indications are atrial fibrillation, type 2 diabet...

    Authors: Jean-Claude Lubanda, Miroslav Chochola, Mikuláš Mlček, Petr Neužil, Josef Marek, Štěpán Havránek, Sylvie Kuchynková, Zdeňka Fingrová, Kao-Hsuan Aimee Huang and Aleš Linhart

    Citation: Journal of Translational Medicine 2017 15:215

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  26. Content type: Research

    Meaningful translational large animal models for cardiac diseases are indispensable for studying disease mechanisms, development of novel therapeutic strategies, and evaluation of potential drugs.

    Authors: Mariann Gyöngyösi, Noemi Pavo, Dominika Lukovic, Katrin Zlabinger, Andreas Spannbauer, Denise Traxler, Georg Goliasch, Ljubica Mandic, Jutta Bergler-Klein, Alfred Gugerell, Andras Jakab, Zsuzsanna Szankai, Levente Toth, Rita Garamvölgyi, Gerald Maurer, Frederic Jaisser…

    Citation: Journal of Translational Medicine 2017 15:202

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  27. Content type: Research

    MicroRNAs (miRNAs) are a class of regulatory RNAs that regulate gene expression post-transcriptionally. Little, however, is known on the expression profile of circulating miRNAs in Tetralogy of Fallot (TOF) pa...

    Authors: Masood Abu-Halima, Eckart Meese, Andreas Keller, Hashim Abdul-Khaliq and Tanja Rädle-Hurst

    Citation: Journal of Translational Medicine 2017 15:156

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  28. Content type: Protocol

    Regular physical activity is recommended for patients with chronic heart failure to improve their functional capacity, and walking is a popular, effective, and safe form of physical activity. Pedometers have s...

    Authors: Tomas Vetrovsky, Michal Siranec, Jiri Parenica, Martin Griva, Jiri Stastny, Jan Precek, Radek Pelouch, Vaclav Bunc, Ales Linhart and Jan Belohlavek

    Citation: Journal of Translational Medicine 2017 15:153

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  29. Content type: Research

    Diabetic nephropathy (DN) is a severe complication of diabetes mellitus (DM). Pancreas or islet transplantation has been reported to prevent the development of DN lesions and ameliorate or reverse existing glo...

    Authors: Yongwei Jiang, Wenjian Zhang, Shiqing Xu, Hua Lin, Weiguo Sui, Honglin Liu, Liang Peng, Qing Fang, Li Chen and Jinning Lou

    Citation: Journal of Translational Medicine 2017 15:147

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  30. Content type: Research

    Radiolabeled RGD peptides detect αvβ3 integrin expression associated with angiogenesis and extracellular matrix remodeling after myocardial infarction. We studied whether cardiac positron emission tomography (PET...

    Authors: Maria Grönman, Miikka Tarkia, Tuomas Kiviniemi, Paavo Halonen, Antti Kuivanen, Timo Savunen, Tuula Tolvanen, Jarmo Teuho, Meeri Käkelä, Olli Metsälä, Mikko Pietilä, Pekka Saukko, Seppo Ylä-Herttuala, Juhani Knuuti, Anne Roivainen and Antti Saraste

    Citation: Journal of Translational Medicine 2017 15:144

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  31. Content type: Research

    The endothelium is a key variable in the pathogenesis of atherosclerosis and its complications, particularly coronary artery disease (CAD). Current evidence suggests that the endothelial status can be regarded...

    Authors: Martino Deidda, Cristina Piras, Christian Cadeddu Dessalvi, Damiana Congia, Emanuela Locci, Federica Ascedu, Gianfranco De Candia, Mauro Cadeddu, Giorgio Lai, Raimondo Pirisi, Luigi Atzori and Giuseppe Mercuro

    Citation: Journal of Translational Medicine 2017 15:112

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  32. Content type: Research

    The lack of early diagnosis, progression markers and effective pharmacological treatment has dramatic unfavourable effects on clinical outcomes in patients with peripheral artery disease (PAD). Addressing thes...

    Authors: Giorgio Aquila, Cinzia Fortini, Antonio Pannuti, Serena Delbue, Micaela Pannella, Marco Bruno Morelli, Cristiana Caliceti, Fausto Castriota, Monica de Mattei, Alessia Ongaro, Agnese Pellati, Pasquale Ferrante, Lucio Miele, Luigi Tavazzi, Roberto Ferrari, Paola Rizzo…

    Citation: Journal of Translational Medicine 2017 15:98

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  33. Content type: Review

    A series of clinical trials have confirmed the correlation between vascular calcification (VC) and cardiovascular events and mortality. However, current treatments have little effects on the regression of VC. ...

    Authors: Adham Sameer A. Bardeesi, Jingwei Gao, Kun Zhang, Suntian Yu, Mengchao Wei, Pinming Liu and Hui Huang

    Citation: Journal of Translational Medicine 2017 15:95

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  34. Content type: Research

    Cell loss and subsequent deterioration of contractile function are hallmarks of chronic heart failure (HF). While apoptosis has been investigated as a participant in the progression of HF, it is unlikely that ...

    Authors: Adrián Szobi, Eva Gonçalvesová, Zoltán V. Varga, Przemyslaw Leszek, Mariusz Kuśmierczyk, Michal Hulman, Ján Kyselovič, Péter Ferdinandy and Adriana Adameová

    Citation: Journal of Translational Medicine 2017 15:86

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    The Erratum to this article has been published in Journal of Translational Medicine 2017 15:103

  35. Content type: Research

    Hypertrophic cardiomyopathy (HCM) patients with early repolarization (ER) pattern are at higher risk of ventricular arrhythmia, yet the genetic background of this situation has not been well investigated. Here...

    Authors: Yanhong Chen, Hector Barajas-Martinez, Dongxiao Zhu, Xihui Wang, Chonghao Chen, Ruijuan Zhuang, Jingjing Shi, Xueming Wu, Yijia Tao, Weidong Jin, Xiaoyan Wang and Dan Hu

    Citation: Journal of Translational Medicine 2017 15:78

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    The Erratum to this article has been published in Journal of Translational Medicine 2017 15:101

  36. Content type: Research

    We aimed to determine the circulating miRNA expression profile associated with BAV and aortic dilation to provide diagnostic and prognostic biomarkers for BAV and/or aortic dilation.

    Authors: Neus Martínez-Micaelo, Raúl Beltrán-Debón, Isabel Baiges, Marta Faiges and Josep M. Alegret

    Citation: Journal of Translational Medicine 2017 15:76

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  37. Content type: Research

    Congenital heart disease (CHD) is a common birth defect, and most cases occur sporadically. Mutations in key genes that are responsible for cardiac development could contribute to CHD. To date, the genetic cau...

    Authors: Yanyan Qian, Deyong Xiao, Xiao Guo, Hongbo Chen, Lili Hao, Xiaojing Ma, Guoying Huang, Duan Ma and Huijun Wang

    Citation: Journal of Translational Medicine 2017 15:69

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  38. Content type: Research

    Cardioprotective value of ischemic post- (IPostC), remote (RIC) conditioning in acute myocardial infarction (AMI) is unclear in clinical trials. To evaluate cardioprotection, most translational animal studies ...

    Authors: Tamás Baranyai, Zoltán Giricz, Zoltán V. Varga, Gábor Koncsos, Dominika Lukovic, András Makkos, Márta Sárközy, Noémi Pávó, András Jakab, Csilla Czimbalmos, Hajnalka Vágó, Zoltán Ruzsa, Levente Tóth, Rita Garamvölgyi, Béla Merkely, Rainer Schulz…

    Citation: Journal of Translational Medicine 2017 15:67

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  39. Content type: Research

    We previously demonstrated that endothelial microparticles (EMPs) are increased in mitral valve diseases and impair valvular endothelial cell function. Perioperative systemic inflammation is an important risk ...

    Authors: Ze-Bang Lin, Hong-Bo Ci, Yan Li, Tian-Pu Cheng, Dong-Hong Liu, Yan-Sheng Wang, Jun Xu, Hao-Xiang Yuan, Hua-Ming Li, Jing Chen, Li Zhou, Zhi-Ping Wang, Xi Zhang, Zhi-Jun Ou and Jing-Song Ou

    Citation: Journal of Translational Medicine 2017 15:4

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  40. Content type: Research

    Thyroid hormones have been associated with renal dysfunction in cross-sectional studies. However, prospective studies exploring the effect of thyroid hormones on renal function decline were sparse and got cont...

    Authors: Xiaolin Huang, Lin Ding, Kui Peng, Lin Lin, Tiange Wang, Zhiyun Zhao, Yu Xu, Jieli Lu, Yuhong Chen, Weiqing Wang, Yufang Bi, Guang Ning and Min Xu

    Citation: Journal of Translational Medicine 2016 14:336

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  41. Content type: Research

    Cyclin-dependent kinase inhibitor 2A/2B (CDKN2A/2B) near chromosome 9p21 have been associated with both atherosclerosis and artery calcification, but the underlying mechanisms remained largely unknown. Considerin...

    Authors: Shuyu Zhou, Yumeng Zhang, Li Wang, Zhizhong Zhang, Biyang Cai, Keting Liu, Hao Zhang, Minhui Dai, Lingli Sun, Xiaomeng Xu, Huan Cai, Xinfeng Liu, Guangming Lu and Gelin Xu

    Citation: Journal of Translational Medicine 2016 14:333

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  42. Content type: Research

    Intrauterine growth restriction (IUGR) is a risk factor for hypertension (HT) and chronic renal disease (CRD). A reduction in the nephron number is proposed to be the underlying mechanism; however, the mechani...

    Authors: Farid Boubred, Laurent Daniel, Christophe Buffat, Michel Tsimaratos, Charles Oliver, Martine Lelièvre-Pégorier and Umberto Simeoni

    Citation: Journal of Translational Medicine 2016 14:331

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  43. Content type: Review

    Cardiovascular diseases (CVD) are an important cause of death worldwide. Anthocyanins are a subgroup of flavonoids found in berries, flowers, fruits and leaves. In epidemiological and clinical studies, these p...

    Authors: Jordano Ferreira Reis, Valter Vinicius Silva Monteiro, Rafaelli de Souza Gomes, Matheus Moraes do Carmo, Glauber Vilhena da Costa, Paula Cardoso Ribera and Marta Chagas Monteiro

    Citation: Journal of Translational Medicine 2016 14:315

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  44. Content type: Research

    Angiopoietin-2 (Ang-2), a ligand of the Tie-2 receptor, plays an important role in maintaining endothelial cells and in destabilizing blood vessels. Collateral artery growth (arteriogenesis) is a key adaptive ...

    Authors: Xiaoyong Tan, Kai Yan, Meiping Ren, Ni Chen, Yongjie Li, Xin Deng, Liqun Wang, Rong Li, Mao Luo, Yong Liu, Yan Liu and Jianbo Wu

    Citation: Journal of Translational Medicine 2016 14:306

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  45. Content type: Research

    Previous studies have suggested that people with obesity showed elevated serum levels of leptin as well as lipid dysfunction and proprotein convertase subtilisin/kexin type 9 (PCSK9) played an important role i...

    Authors: Ying Du, Sha Li, Chuan-Jue Cui, Yan Zhang, Sheng-Hua Yang and Jian-Jun Li

    Citation: Journal of Translational Medicine 2016 14:276

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  46. Content type: Review

    Research and development of new drugs requires both long time and high costs, whereas safety and tolerability profiles make the success rate of approval very low. Drug repurposing, applying known drugs and com...

    Authors: Junichi Ishida, Masaaki Konishi, Nicole Ebner and Jochen Springer

    Citation: Journal of Translational Medicine 2016 14:269

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  47. Content type: Research

    Urtica dioica has traditionally been used in the management of cardiovascular disorders especially hypertension. The aim of this study was to explore pharmacological base of its use in...

    Authors: Rahila Qayyum, Hafiz Misbah-ud-Din Qamar, Shamim Khan, Umme Salma, Taous Khan and Abdul Jabbar Shah

    Citation: Journal of Translational Medicine 2016 14:254

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  48. Content type: Research

    Understanding the underlying mechanism of thrombus formation and its components is critical for effective prevention and treatment of ischemic stroke. The generation of thrombotic clots requires conversion of ...

    Authors: Slaven Pikija, Vladimir Trkulja, Johannes Sebastian Mutzenbach, Mark R. McCoy, Patricia Ganger and Johann Sellner

    Citation: Journal of Translational Medicine 2016 14:250

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  49. Content type: Research

    Although recent studies indicate that epicardial adipose tissue expresses brown fat-like genes, such as PGC1α, UCP1 and PRDM16, the association of these genes with type 2 diabetes mellitus (DM2) in coronary ar...

    Authors: Inmaculada Moreno-Santos, Luis Miguel Pérez-Belmonte, Manuel Macías-González, María José Mataró, Daniel Castellano, Miguel López-Garrido, Carlos Porras-Martín, Pedro L. Sánchez-Fernández, Juan José Gómez-Doblas, Fernando Cardona, Eduardo de Teresa-Galván and Manuel Jiménez-Navarro

    Citation: Journal of Translational Medicine 2016 14:243

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  50. Content type: Research

    The Wellcome Trust, the World Health Organization, and cardiologists have advocated for the idea of a “polypill” containing multiple cardiovascular drugs to be co-formulated into a single pill for over a decad...

    Authors: Reed F. Beall, Jon-David R. Schwalm, Mark D. Huffman, Tara McCready, Salim Yusuf and Amir Attaran

    Citation: Journal of Translational Medicine 2016 14:242

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