Cardiovascular, metabolic and Lipoprotein translation

Section edited by Nehal N. Mehta

This section aims to speed mechanistic understanding, development of novel diagnostics and potential therapeutic targets within cardiovascular, metabolic diseases and lipoprotein diseases. The section is open to experiments involving cellular models, animal models, observational studies and clinical trials that are distinguished for their novelty in approach, design or indication, timeliness, and unique ability to translate laboratory concepts from the bench to the bedside.

Highest priority will be given to those manuscripts which are specifically focused on cardiovascular, metabolic and lipid disorders which enrich understanding of disease mechanism, novel therapeutics and state-of-the-art scientific technique.

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  1. Review

    GlycA, a novel biomarker of systemic inflammation and cardiovascular disease risk

    GlycA is a novel spectroscopic marker of systemic inflammation with low intra-individual variability and other attributes favoring its clinical use in patients with chronic inflammatory and autoimmune diseases...

    Margery A. Connelly, James D. Otvos, Irina Shalaurova, Martin P. Playford and Nehal N. Mehta

    Journal of Translational Medicine 2017 15:219

    Published on: 27 October 2017

  2. Research

    Haemoadsorption reduces the inflammatory response and improves blood flow during ex vivo renal perfusion in an experimental model

    Ex-vivo normothermic perfusion strategies are a promising new instrument in organ transplantation. The perfusion conditions are designed to be protective however the artificial environment can induce a local i...

    Sarah A. Hosgood, Tom Moore, Theresa Kleverlaan, Tom Adams and Michael L. Nicholson

    Journal of Translational Medicine 2017 15:216

    Published on: 25 October 2017

  3. Research

    The effect of renal denervation in an experimental model of chronic renal insufficiency, The REmnant kidney Denervation In Pigs study (REDIP study)

    Renal denervation (RDN) is a promising therapeutic method in cardiology. Its currently most investigated indication is resistant hypertension. Other potential indications are atrial fibrillation, type 2 diabet...

    Jean-Claude Lubanda, Miroslav Chochola, Mikuláš Mlček, Petr Neužil, Josef Marek, Štěpán Havránek, Sylvie Kuchynková, Zdeňka Fingrová, Kao-Hsuan Aimee Huang and Aleš Linhart

    Journal of Translational Medicine 2017 15:215

    Published on: 25 October 2017

  4. Research

    Porcine model of progressive cardiac hypertrophy and fibrosis with secondary postcapillary pulmonary hypertension

    Meaningful translational large animal models for cardiac diseases are indispensable for studying disease mechanisms, development of novel therapeutic strategies, and evaluation of potential drugs.

    Mariann Gyöngyösi, Noemi Pavo, Dominika Lukovic, Katrin Zlabinger, Andreas Spannbauer, Denise Traxler, Georg Goliasch, Ljubica Mandic, Jutta Bergler-Klein, Alfred Gugerell, Andras Jakab, Zsuzsanna Szankai, Levente Toth, Rita Garamvölgyi, Gerald Maurer, Frederic Jaisser…

    Journal of Translational Medicine 2017 15:202

    Published on: 6 October 2017

  5. Research

    Analysis of circulating microRNAs in patients with repaired Tetralogy of Fallot with and without heart failure

    MicroRNAs (miRNAs) are a class of regulatory RNAs that regulate gene expression post-transcriptionally. Little, however, is known on the expression profile of circulating miRNAs in Tetralogy of Fallot (TOF) pa...

    Masood Abu-Halima, Eckart Meese, Andreas Keller, Hashim Abdul-Khaliq and Tanja Rädle-Hurst

    Journal of Translational Medicine 2017 15:156

    Published on: 10 July 2017

  6. Protocol

    Effect of a 6-month pedometer-based walking intervention on functional capacity in patients with chronic heart failure with reduced (HFrEF) and with preserved (HFpEF) ejection fraction: study protocol for two multicenter randomized controlled trials

    Regular physical activity is recommended for patients with chronic heart failure to improve their functional capacity, and walking is a popular, effective, and safe form of physical activity. Pedometers have s...

    Tomas Vetrovsky, Michal Siranec, Jiri Parenica, Martin Griva, Jiri Stastny, Jan Precek, Radek Pelouch, Vaclav Bunc, Ales Linhart and Jan Belohlavek

    Journal of Translational Medicine 2017 15:153

    Published on: 3 July 2017

  7. Research

    Transplantation of human fetal pancreatic progenitor cells ameliorates renal injury in streptozotocin-induced diabetic nephropathy

    Diabetic nephropathy (DN) is a severe complication of diabetes mellitus (DM). Pancreas or islet transplantation has been reported to prevent the development of DN lesions and ameliorate or reverse existing glo...

    Yongwei Jiang, Wenjian Zhang, Shiqing Xu, Hua Lin, Weiguo Sui, Honglin Liu, Liang Peng, Qing Fang, Li Chen and Jinning Lou

    Journal of Translational Medicine 2017 15:147

    Published on: 27 June 2017

  8. Research

    Imaging of αvβ3 integrin expression in experimental myocardial ischemia with [68Ga]NODAGA-RGD positron emission tomography

    Radiolabeled RGD peptides detect αvβ3 integrin expression associated with angiogenesis and extracellular matrix remodeling after myocardial infarction. We studied whether cardiac positron emission tomography (PET...

    Maria Grönman, Miikka Tarkia, Tuomas Kiviniemi, Paavo Halonen, Antti Kuivanen, Timo Savunen, Tuula Tolvanen, Jarmo Teuho, Meeri Käkelä, Olli Metsälä, Mikko Pietilä, Pekka Saukko, Seppo Ylä-Herttuala, Juhani Knuuti, Anne Roivainen and Antti Saraste

    Journal of Translational Medicine 2017 15:144

    Published on: 19 June 2017

  9. Research

    Blood metabolomic fingerprint is distinct in healthy coronary and in stenosing or microvascular ischemic heart disease

    The endothelium is a key variable in the pathogenesis of atherosclerosis and its complications, particularly coronary artery disease (CAD). Current evidence suggests that the endothelial status can be regarded...

    Martino Deidda, Cristina Piras, Christian Cadeddu Dessalvi, Damiana Congia, Emanuela Locci, Federica Ascedu, Gianfranco De Candia, Mauro Cadeddu, Giorgio Lai, Raimondo Pirisi, Luigi Atzori and Giuseppe Mercuro

    Journal of Translational Medicine 2017 15:112

    Published on: 23 May 2017

  10. Research

    Distinct gene expression profiles associated with Notch ligands Delta-like 4 and Jagged1 in plaque material from peripheral artery disease patients: a pilot study

    The lack of early diagnosis, progression markers and effective pharmacological treatment has dramatic unfavourable effects on clinical outcomes in patients with peripheral artery disease (PAD). Addressing thes...

    Giorgio Aquila, Cinzia Fortini, Antonio Pannuti, Serena Delbue, Micaela Pannella, Marco Bruno Morelli, Cristiana Caliceti, Fausto Castriota, Monica de Mattei, Alessia Ongaro, Agnese Pellati, Pasquale Ferrante, Lucio Miele, Luigi Tavazzi, Roberto Ferrari, Paola Rizzo…

    Journal of Translational Medicine 2017 15:98

    Published on: 4 May 2017

  11. Review

    A novel role of cellular interactions in vascular calcification

    A series of clinical trials have confirmed the correlation between vascular calcification (VC) and cardiovascular events and mortality. However, current treatments have little effects on the regression of VC. ...

    Adham Sameer A. Bardeesi, Jingwei Gao, Kun Zhang, Suntian Yu, Mengchao Wei, Pinming Liu and Hui Huang

    Journal of Translational Medicine 2017 15:95

    Published on: 3 May 2017

  12. Research

    Analysis of necroptotic proteins in failing human hearts

    Cell loss and subsequent deterioration of contractile function are hallmarks of chronic heart failure (HF). While apoptosis has been investigated as a participant in the progression of HF, it is unlikely that ...

    Adrián Szobi, Eva Gonçalvesová, Zoltán V. Varga, Przemyslaw Leszek, Mariusz Kuśmierczyk, Michal Hulman, Ján Kyselovič, Péter Ferdinandy and Adriana Adameová

    Journal of Translational Medicine 2017 15:86

    Published on: 28 April 2017

    The Erratum to this article has been published in Journal of Translational Medicine 2017 15:103

  13. Research

    Novel trigenic CACNA1C/DES/MYPN mutations in a family of hypertrophic cardiomyopathy with early repolarization and short QT syndrome

    Hypertrophic cardiomyopathy (HCM) patients with early repolarization (ER) pattern are at higher risk of ventricular arrhythmia, yet the genetic background of this situation has not been well investigated. Here...

    Yanhong Chen, Hector Barajas-Martinez, Dongxiao Zhu, Xihui Wang, Chonghao Chen, Ruijuan Zhuang, Jingjing Shi, Xueming Wu, Yijia Tao, Weidong Jin, Xiaoyan Wang and Dan Hu

    Journal of Translational Medicine 2017 15:78

    Published on: 20 April 2017

    The Erratum to this article has been published in Journal of Translational Medicine 2017 15:101

  14. Research

    Specific circulating microRNA signature of bicuspid aortic valve disease

    We aimed to determine the circulating miRNA expression profile associated with BAV and aortic dilation to provide diagnostic and prognostic biomarkers for BAV and/or aortic dilation.

    Neus Martínez-Micaelo, Raúl Beltrán-Debón, Isabel Baiges, Marta Faiges and Josep M. Alegret

    Journal of Translational Medicine 2017 15:76

    Published on: 11 April 2017

  15. Research

    Multiple gene variations contributed to congenital heart disease via GATA family transcriptional regulation

    Congenital heart disease (CHD) is a common birth defect, and most cases occur sporadically. Mutations in key genes that are responsible for cardiac development could contribute to CHD. To date, the genetic cau...

    Yanyan Qian, Deyong Xiao, Xiao Guo, Hongbo Chen, Lili Hao, Xiaojing Ma, Guoying Huang, Duan Ma and Huijun Wang

    Journal of Translational Medicine 2017 15:69

    Published on: 3 April 2017

  16. Research

    In vivo MRI and ex vivo histological assessment of the cardioprotection induced by ischemic preconditioning, postconditioning and remote conditioning in a closed-chest porcine model of reperfused acute myocardial infarction: importance of microvasculature

    Cardioprotective value of ischemic post- (IPostC), remote (RIC) conditioning in acute myocardial infarction (AMI) is unclear in clinical trials. To evaluate cardioprotection, most translational animal studies ...

    Tamás Baranyai, Zoltán Giricz, Zoltán V. Varga, Gábor Koncsos, Dominika Lukovic, András Makkos, Márta Sárközy, Noémi Pávó, András Jakab, Csilla Czimbalmos, Hajnalka Vágó, Zoltán Ruzsa, Levente Tóth, Rita Garamvölgyi, Béla Merkely, Rainer Schulz…

    Journal of Translational Medicine 2017 15:67

    Published on: 1 April 2017

  17. Research

    Endothelial microparticles are increased in congenital heart diseases and contribute to endothelial dysfunction

    We previously demonstrated that endothelial microparticles (EMPs) are increased in mitral valve diseases and impair valvular endothelial cell function. Perioperative systemic inflammation is an important risk ...

    Ze-Bang Lin, Hong-Bo Ci, Yan Li, Tian-Pu Cheng, Dong-Hong Liu, Yan-Sheng Wang, Jun Xu, Hao-Xiang Yuan, Hua-Ming Li, Jing Chen, Li Zhou, Zhi-Ping Wang, Xi Zhang, Zhi-Jun Ou and Jing-Song Ou

    Journal of Translational Medicine 2017 15:4

    Published on: 4 January 2017

  18. Research

    Thyroid hormones associate with risk of incident chronic kidney disease and rapid decline in renal function: a prospective investigation

    Thyroid hormones have been associated with renal dysfunction in cross-sectional studies. However, prospective studies exploring the effect of thyroid hormones on renal function decline were sparse and got cont...

    Xiaolin Huang, Lin Ding, Kui Peng, Lin Lin, Tiange Wang, Zhiyun Zhao, Yu Xu, Jieli Lu, Yuhong Chen, Weiqing Wang, Yufang Bi, Guang Ning and Min Xu

    Journal of Translational Medicine 2016 14:336

    Published on: 3 December 2016

  19. Research

    CDKN2B methylation is associated with carotid artery calcification in ischemic stroke patients

    Cyclin-dependent kinase inhibitor 2A/2B (CDKN2A/2B) near chromosome 9p21 have been associated with both atherosclerosis and artery calcification, but the underlying mechanisms remained largely unknown. Considerin...

    Shuyu Zhou, Yumeng Zhang, Li Wang, Zhizhong Zhang, Biyang Cai, Keting Liu, Hao Zhang, Minhui Dai, Lingli Sun, Xiaomeng Xu, Huan Cai, Xinfeng Liu, Guangming Lu and Gelin Xu

    Journal of Translational Medicine 2016 14:333

    Published on: 1 December 2016

  20. Research

    The magnitude of nephron number reduction mediates intrauterine growth-restriction-induced long term chronic renal disease in the rat. A comparative study in two experimental models

    Intrauterine growth restriction (IUGR) is a risk factor for hypertension (HT) and chronic renal disease (CRD). A reduction in the nephron number is proposed to be the underlying mechanism; however, the mechani...

    Farid Boubred, Laurent Daniel, Christophe Buffat, Michel Tsimaratos, Charles Oliver, Martine Lelièvre-Pégorier and Umberto Simeoni

    Journal of Translational Medicine 2016 14:331

    Published on: 30 November 2016

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