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Cardiovascular, Metabolic and Lipoprotein Translation

Section edited by Nehal N. Mehta and Tommaso Angelone
© Juan Gärtner/ stock.adob

This section aims to speed mechanistic understanding, development of novel diagnostics and potential therapeutic targets within cardiovascular, metabolic diseases and lipoprotein diseases. The section is open to experiments involving cellular models, animal models, observational studies and clinical trials that are distinguished for their novelty in approach, design or indication, timeliness, and unique ability to translate laboratory concepts from the bench to the bedside.

Highest priority will be given to those manuscripts which are specifically focused on cardiovascular, metabolic and lipid disorders which enrich understanding of disease mechanism, novel therapeutics and state-of-the-art scientific technique.

Featured articles


Immune cell phenotyping in low blood volumes for assessment of cardiovascular disease risk, development, and progression: a pilot study

Research | Yvonne Baumer et al


Comprehensive analysis of differential immunocyte infiltration and the potential ceRNA networks during epicardial adipose tissue development in congenital heart disease

Research | Li Ma et al


Extracellular vesicles in diabetes mellitus induce alterations in endothelial cell morphology and migration​​​​​​​

Research | Sharon F Wu et al

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  1. Heart failure with preserved ejection fraction (HFpEF) accounts for approximately 50% of heart failure cases. The molecular mechanisms by which HFpEF leads to impaired diastolic function of the heart have not ...

    Authors: Yixiao Xiong, Xin Liu, Ling Jiang, Tao Hao, Yanyan Wang and Tao Li
    Citation: Journal of Translational Medicine 2024 22:199
  2. Coronary artery bypass graft (CABG) is generally used to treat complex coronary artery disease. Treatment success is affected by neointimal hyperplasia (NIH) of graft and anastomotic sites. Although sirolimus ...

    Authors: Ji-yeon Ryu, Eui Hwa Jang, JiYong Lee, Jung-Hwan Kim and Young-Nam Youn
    Citation: Journal of Translational Medicine 2024 22:166
  3. Pulmonary arterial hypertension (PAH) is a severe cardiopulmonary disease characterized by complement dependent and proinflammatory activation of macrophages. However, effective treatment for complement activa...

    Authors: Lei Dai, Yu Chen, Jinhua Wu, Zhen He, Yueqi Zhang, Wenjun Zhang, Yang Xie, Hesong Zeng and Xiaodan Zhong
    Citation: Journal of Translational Medicine 2024 22:164
  4. Cardiac fibroblast activation protein (FAP) has an emerging role in heart failure (HF). A paradoxical reduction in its levels in pathological conditions associated with acute processes has been observed. We ai...

    Authors: Marta Delgado-Arija, Patricia Genovés, Lorena Pérez-Carrillo, Irene González-Torrent, Isaac Giménez-Escamilla, Luis Martínez-Dolz, Manuel Portolés, Estefanía Tarazón and Esther Roselló-Lletí
    Citation: Journal of Translational Medicine 2024 22:124
  5. The sarcoplasmic reticulum (SR) Ca2+ ATPase (SERCA2a) depression substantially contributes to diastolic dysfunction in heart failure (HF), suggesting that SERCA2a stimulation may be a mechanism-based HF therapy. ...

    Authors: Martina Arici, Shih-Che Hsu, Mara Ferrandi, Paolo Barassi, Carlotta Ronchi, Eleonora Torre, Andrea Luraghi, Gwo-Jyh Chang, Patrizia Ferrari, Giuseppe Bianchi, Francesco Peri, Antonio Zaza and Marcella Rocchetti
    Citation: Journal of Translational Medicine 2024 22:77
  6. Long Intergenic noncoding RNA predicting CARdiac remodeling (LIPCAR) is a long noncoding RNA identified in plasma of patients after myocardial infarction (MI) to be associated with left ventricle remodeling (L...

    Authors: Annie Turkieh, Olivia Beseme, Ouriel Saura, Henri Charrier, Jean-Baptiste Michel, Philippe Amouyel, Thomas Thum, Christophe Bauters and Florence Pinet
    Citation: Journal of Translational Medicine 2024 22:31
  7. Pulmonary hypertension (PH), an infrequent disease, is characterized by excessive pulmonary vascular remodeling and proliferation of pulmonary artery smooth muscle cells (PASMCs). However, its underlying molec...

    Authors: Yingli Liu, Li Zhu, Yue Ming, Zhuhua Wu, Lili Zhang, Qi Chen and Yong Qi
    Citation: Journal of Translational Medicine 2023 21:821
  8. Heart transplantation (HTX) is the standard treatment for end-stage heart failure. However, reperfusion following an ischemic period can contribute to myocardial injury. Neutrophil infiltration, along with the...

    Authors: Baoer Liu, Brice Korkmaz, Patricia Kraft, Tobias Mayer, Alex A. Sayour, Marc A. Grundl, Roxane Domain, Matthias Karck, Gábor Szabó and Sevil Korkmaz-Icöz
    Citation: Journal of Translational Medicine 2023 21:799
  9. Dilated cardiomyopathy (DCM) is a severe, non-ischemic heart disease which ultimately results in heart failure (HF). Decades of research on DCM have revealed diverse aetiologies. Among them, familial DCM is th...

    Authors: Chia Yee Tan, Pui Shi Chan, Hansen Tan, Sung Wei Tan, Chang Jie Mick Lee, Jiong-Wei Wang, Shu Ye, Hendrikje Werner, Ying Jie Loh, Yin Loon Lee, Matthew Ackers-Johnson, Roger S. Y. Foo and Jianming Jiang
    Citation: Journal of Translational Medicine 2023 21:690
  10. Atherosclerosis is a chronic inflammatory process induced by the influx and entrapment of excess lipoproteins into the intima media of arteries. Previously, our lab demonstrated that systemic PTP1B inhibition ...

    Authors: Helk Oliver, Dekeryte Ruta, Dawn Thompson, Sarah Kamli-Salino, Sam Philip, Heather M. Wilson, Nimesh Mody and Mirela Delibegovic
    Citation: Journal of Translational Medicine 2023 21:715
  11. Heart diseases are among the leading causes of death worldwide, many of which lead to pathological cardiomyocyte hypertrophy and capillary rarefaction in both patients and animal models, the quantification of ...

    Authors: Patrick Droste, Dickson W. L. Wong, Mathias Hohl, Saskia von Stillfried, Barbara M. Klinkhammer and Peter Boor
    Citation: Journal of Translational Medicine 2023 21:666
  12. Inflammation in cardiac adipose tissue (AT) is associated with atherosclerosis. We investigated whether the epicardial-, pericardial and pre-sternal subcutaneous AT (EAT, PAT and SAT) expression of Sirtuin1 (S...

    Authors: Trine Baur Opstad, Bianca Papotti, Sissel Åkra, Charlotte Holst Hansen, Bjørn Braathen, Theis Tønnessen, Svein Solheim and Ingebjørg Seljeflot
    Citation: Journal of Translational Medicine 2023 21:644
  13. Vibrational spectroscopy can be a valuable tool to monitor the markers of cardiovascular diseases. In the present work, we explored the vibrational spectroscopy characteristics of the cardiac tissue in an expe...

    Authors: Leonardo Pioppi, Reza Parvan, Alan Samrend, Gustavo Jose Justo Silva, Marco Paolantoni, Paola Sassi and Alessandro Cataliotti
    Citation: Journal of Translational Medicine 2023 21:617
  14. Long-chain acyl-carnitines (ACs) are potential arrhythmogenic metabolites. Their role in atrial fibrillation (AF) remains incompletely understood. Using a systems medicine approach, we assessed the contributio...

    Authors: Julia Krause, Alexander Nickel, Alexandra Madsen, Hamish M. Aitken-Buck, A. M. Stella Stoter, Jessica Schrapers, Francisco Ojeda, Kira Geiger, Melanie Kern, Michael Kohlhaas, Edoardo Bertero, Patrick Hofmockel, Florian Hübner, Ines Assum, Matthias Heinig, Christian Müller…
    Citation: Journal of Translational Medicine 2023 21:566
  15. Cardiovascular diseases (CVDs) continue to exert a significant impact on global mortality rates, encompassing conditions like pulmonary arterial hypertension (PAH), atherosclerosis (AS), and myocardial infarct...

    Authors: Qian Yan, Shasha Liu, Yang Sun, Chen Chen, Songwei Yang, Meiyu Lin, Junpeng Long, Jiao Yao, Yuting Lin, Fan Yi, Lei Meng, Yong Tan, Qidi Ai, Naihong Chen and Yantao Yang
    Citation: Journal of Translational Medicine 2023 21:519
  16. Pulmonary arterial hypertension (PAH) is a multifactorial disease associated with the remodeling of pulmonary blood vessels. If left unaddressed, PAH can lead to right heart failure and even death. Multiple bi...

    Authors: Jaydev Dave, Vineeta Jagana, Radoslav Janostiak and Malik Bisserier
    Citation: Journal of Translational Medicine 2023 21:477
  17. Dilated cardiomyopathy (DCM) is one of the most frequent causes of heart failure and heart transplantation (HTx). The genetic basis of DCM among patients undergoing HTx remains to be further studied. This stud...

    Authors: Hong Lian, Shen Song, Wenzheng Chen, Anteng Shi, Haobin Jiang and Shengshou Hu
    Citation: Journal of Translational Medicine 2023 21:476
  18. Cardiopulmonary bypass (CPB) is associated with systemic inflammation, featuring increased levels of circulating pro-inflammatory cytokines. Intra-operative ultrafiltration extracts fluid and inflammatory fact...

    Authors: Joel Bierer, Roger Stanzel, Mark Henderson, Suvro Sett, John Sapp, Pantelis Andreou, Jean S. Marshall and David Horne
    Citation: Journal of Translational Medicine 2023 21:439
  19. Epicardial adipose tissue (EAT) secretome induces fibrosis. Fibrosis, primarily extracellular matrix (ECM) produced by fibroblasts, creates a substrate for atrial fibrillation (AF). Whether the EAT secretome f...

    Authors: Eva R. Meulendijks, Rushd F. M. Al-Shama, Makiri Kawasaki, Benedetta Fabrizi, Jolien Neefs, Robin Wesselink, Auriane C. Ernault, Sander Piersma, Thang V. Pham, Connie R. Jimenez, Jaco C. Knol, Wim J. P. van Boven, Antoine H. G. Driessen, Tim A. C. de Vries, Britt van der Leeden, Hans W. M. Niessen…
    Citation: Journal of Translational Medicine 2023 21:366
  20. The distribution of ACE2 and accessory proteases (ANAD17 and CTSL) in cardiovascular tissue and the host cell receptor binding of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are crucial to und...

    Authors: Cong Chen, Jie Wang, Yong-Mei Liu and Jun Hu
    Citation: Journal of Translational Medicine 2023 21:358
  21. We previously demonstrated that an Italian family affected by a severe dilated cardiomyopathy (DCM) with history of sudden deaths at young age, carried a mutation in the Lmna gene encoding for a truncated variant...

    Authors: Giusy Pietrafesa, Roberta De Zio, Simona Ida Scorza, Maria Francesca Armentano, Martino Pepe, Cinzia Forleo, Giuseppe Procino, Andrea Gerbino, Maria Svelto and Monica Carmosino
    Citation: Journal of Translational Medicine 2023 21:340
  22. Exosomes (EXOs), tiny extracellular vesicles that facilitate cell–cell communication, are being explored as a heart failure treatment, although the features of the cell source restrict their efficacy. Fibrobla...

    Authors: Gaia Papini, Giulia Furini, Marco Matteucci, Vanessa Biemmi, Valentina Casieri, Nicole Di Lascio, Giuseppina Milano, Lucia Rosa Chincoli, Francesco Faita, Lucio Barile and Vincenzo Lionetti
    Citation: Journal of Translational Medicine 2023 21:313
  23. Oncostatin M (OSM) is a secreted cytokine of the interleukin (IL)-6 family that induces biological effects by activating functional receptor complexes of the common signal transducing component glycoprotein 13...

    Authors: Yizhou Feng, Yuan Yuan, Hongxia Xia, Zhaopeng Wang, Yan Che, Zhefu Hu, Jiangyang Deng, Fangfang Li, Qingqing Wu, Zhouyan Bian, Heng Zhou, Difei Shen and Qizhu Tang
    Citation: Journal of Translational Medicine 2023 21:290
  24. COVID-19, the current global pandemic caused by SARS-CoV-2 infection, can damage the heart and lead to heart failure (HF) and even cardiac death. The 2',5'-oligoadenylate synthetase (OAS) gene family encode in...

    Authors: Li-Juan Gao, Zhong-Mei He, Yi-Ying Li, Rui-Rui Yang, Min Yan, Xuan Shang and Ji-Min Cao
    Citation: Journal of Translational Medicine 2023 21:212
  25. Emerging evidence suggests that DNA methylation can be affected by physical activities and is associated with cardiac fibrosis. This translational research examined the implications of DNA methylation associat...

    Authors: Chih-Chin Hsu, Jong-Shyan Wang, Yu-Chiau Shyu, Tieh-Cheng Fu, Yu-Hsiang Juan, Shin-Sheng Yuan, Chao-Hung Wang, Chi-Hsiao Yeh, Po-Cheng Liao, Hsin-Yi Wu and Pang-Hung Hsu
    Citation: Journal of Translational Medicine 2023 21:187
  26. Recent studies have shown the implication of the ROBO-SLIT pathway in heart development. Within this study, we aimed to further assess the implication of the ROBO and SLIT genes mainly in bicuspid aortic valve (B...

    Authors: Hager Jaouadi, Chris Jopling, Fanny Bajolle, Alexis Théron, Adèle Faucherre, Hilla Gerard, Sarab Al Dybiat, Caroline Ovaert, Damien Bonnet, Jean-François Avierinos and Stéphane Zaffran
    Citation: Journal of Translational Medicine 2023 21:160
  27. Renal denervation (RDN) was still performed without any intra-procedural method for nerve mapping. Whether renal nerve stimulation (RNS) is an efficient way to identify renal autonomic innervation and optimize...

    Authors: Hang Liu, Yidan Li, Hao Zhou, Weijie Chen, Yanping Xu, Huaan Du, Bo Zhang, Tianli Xia, Dan Li, Zhenhong Ou, Ruotian Tang, Qingsong Chen, Binyi Zhao and Yuehui Yin
    Citation: Journal of Translational Medicine 2023 21:100
  28. Atherosclerosis is driven by synergistic interactions between pathological biomechanical and lipid metabolic factors. Long noncoding RNAs (LncRNAs) have been implicated in atherogenesis. The purpose of this st...

    Authors: Yang Hong, Yue Zhang, Hui Chen, Xueqing Tang, Hongrui Zhao, Ziyu Meng, Xueling Jia, Wenfeng Liu, Xiaohan Li, Lin Wang, Xinrui Zhong, Xuefeng Bai, Heyang Sun, Philipp Kopylov, Bestavashvili Afina, Dmitry Shchekochikhin…
    Citation: Journal of Translational Medicine 2023 21:97
  29. Arsenic trioxide (ATO) is the first-line therapeutic drug for acute promyelocytic leukemia. However, the cardiotoxicity of ATO limits its clinical application. This study aims to explore the long noncoding RNA...

    Authors: Xiuyun Shen, Fengnan Zhi, Chunpeng Shi, Jincheng Xu, Yuqiu Chao, Juan Xu, Yanan Jiang, Yunlong Bai and Baofeng Yang
    Citation: Journal of Translational Medicine 2023 21:52

    The Correction to this article has been published in Journal of Translational Medicine 2023 21:170

  30. Growth arrest-specific 6 (GAS6) is a vitamin K-dependent protein related to inflammation, fibrosis, as well as platelet function. Genetic ablation of GAS6 in mice protects against cardiac hypertrophy and dysfu...

    Authors: Teng Ma, Rongrong Huang, Yanhua Xu, Yangbo Lv, Yifan Liu, Xin Pan, Jia Dong, Di Gao, Zeyu Wang, Fenglei Zhang, Chunxi Yan, Sang-Bing Ong, Yang Su and Dachun Xu
    Citation: Journal of Translational Medicine 2023 21:21
  31. Cardiovascular disease is a leading cause of morbidity and mortality. Oral health is associated with smoking and cardiovascular outcomes, but there are gaps in knowledge of many mechanisms connecting smoking t...

    Authors: Katherine A. Maki, Sukirth M. Ganesan, Brianna Meeks, Nicole Farmer, Narjis Kazmi, Jennifer J. Barb, Paule V. Joseph and Gwenyth R. Wallen
    Citation: Journal of Translational Medicine 2022 20:584
  32. Mounting evidence has revealed the dynamic variations in the cellular status and phenotype of the smooth muscle cell (SMC) are vital for shaping the atherosclerotic plaque microenvironment and ultimately mappi...

    Authors: Ge Zhang, Zaoqu Liu, Jinhai Deng, Long Liu, Yu Li, Siyuan Weng, Chunguang Guo, Zhaokai Zhou, Li Zhang, Xiaofang Wang, Gangqiong Liu, Jiacheng Guo, Jing Bai, Yunzhe Wang, Youyou Du, Tao-Sheng Li…
    Citation: Journal of Translational Medicine 2022 20:568
  33. Arteriovenous fistula (AVF) maturation is a process involving remodeling of venous arm of the AVFs. It is a challenge to balance adaptive AVF remodeling and neointima formation. In this study we temporally con...

    Authors: Qunying Guo, Guang Chen, Hunter Cheng, Ying Qing, Luan Truong, Quan Ma, Yun Wang and Jizhong Cheng
    Citation: Journal of Translational Medicine 2022 20:543
  34. The crosstalk of purine biosynthesis and metabolism exists to balance the cell energy production, proliferation, survival and cytoplasmic environment stability, but disorganized mechanics of with respect to de...

    Authors: Ge Wang, Rongjun Zou, Libao Liu, Zongtao Wang, Zengxiao Zou, Songtao Tan, Wenliu Xu and Xiaoping Fan
    Citation: Journal of Translational Medicine 2022 20:532
  35. Cardiac mesenchymal stromal cells (C-MSC) were recently shown to differentiate into adipocytes and myofibroblasts to promote the aberrant remodeling of cardiac tissue that characterizes arrhythmogenic cardiomy...

    Authors: Angela S. Maione, Pawan Faris, Lara Iengo, Valentina Catto, Luca Bisonni, Francesco Lodola, Sharon Negri, Michela Casella, Anna Guarino, Gianluca Polvani, Marina Cerrone, Claudio Tondo, Giulio Pompilio, Elena Sommariva and Francesco Moccia
    Citation: Journal of Translational Medicine 2022 20:522
  36. Abdominal aortic aneurysm (AAA) represents the serious vascular degenerative disorder, which causes high incidence and mortality. Alpha-ketoglutarate (AKG), a crucial metabolite in the tricarboxylic acid (TCA)...

    Authors: Junjun Liu, Mingyuan Liu, Jiaxuan Feng, Hongqiao Zhu, Jianlie Wu, Heng Zhang, Shun Xiao, Zaiping Jing, Jian Zhou, Haitao Niu and Mingjin Guo
    Citation: Journal of Translational Medicine 2022 20:461
  37. This study incorporates the results of subgroup analyses of currently published randomized controlled trials (RCTs) and real-world cohort studies to compare the effectiveness and safety of new direct oral anti...

    Authors: Xuedong Jia, Zhao Yin, Wan Zhang, Shuzhang Du and Jian Kang
    Citation: Journal of Translational Medicine 2022 20:441
  38. Atrial fibrosis plays a critical role in the development of atrial fibrillation (AF). Exosomes are a promising cell-free therapeutic approach for the treatment of AF. The purposes of this study were to explore...

    Authors: Hongting Hao, Sen Yan, Xinbo Zhao, Xuejie Han, Ning Fang, Yun Zhang, Chenguang Dai, Wenpeng Li, Hui Yu, Yunlong Gao, Dingyu Wang, Qiang Gao, Yu Duan, Yue Yuan and Yue Li
    Citation: Journal of Translational Medicine 2022 20:407
  39. Clarkson disease (monoclonal gammopathy-associated idiopathic systemic capillary leak syndrome, ISCLS) is a rare idiopathic condition marked by transient, relapsing-remitting episodes of systemic microvascular...

    Authors: Zhihui Xie, Magne Børset, Kjell Svéen, Ole Wilhelm Bøe, Eunice C. Chan, Justin B. Lack, Katherine M. Hornick, Franco Verlicchi, A. Robin Eisch, Remo Melchio, Arkadiusz Z. Dudek and Kirk M. Druey
    Citation: Journal of Translational Medicine 2022 20:380
  40. The purpose of this study was to observe the harm of circadian misalignment (CM), caused by an inverted photoperiod (IP), on the hearts of the adolescent Wistar rats, and to explore the mechanisms leading to h...

    Authors: YunLei Wang, YuanYuan Hou, ShaoFei Song, Yao Zuo, Yan Yu, YaFei Chi and Tong Zhang
    Citation: Journal of Translational Medicine 2022 20:352
  41. Asprosin, a newly discovered adipokine, is a C-terminal cleavage product of profibrillin. Asprosin has been reported to participate in lipid metabolism and cardiovascular disease, but its role in atherogenesis...

    Authors: Jin Zou, Can Xu, Zhen-Wang Zhao, Shan-Hui Yin and Gang Wang
    Citation: Journal of Translational Medicine 2022 20:337
  42. The immune system plays a vital role in the pathophysiology of acute myocardial infarction (AMI). However, the exact immune related mechanism is still unclear. This research study aimed to identify key immune-...

    Authors: Peng-Fei Zheng, Qiong-Chao Zou, Lu-Zhu Chen, Peng Liu, Zheng-Yu Liu and Hong-Wei Pan
    Citation: Journal of Translational Medicine 2022 20:321
  43. Cardiovascular diseases (CVDs) are a significant cause of mortality worldwide and are characterized by severe atherosclerosis (AS) in patients. However, the molecular mechanism of AS formation remains elusive....

    Authors: Jiaxin Hu, Ying Zhang, Liaoping Hu, Haiting Chen, Han Wu, Jianzhou Chen, Jun Xie, Biao Xu and Zhonghai Wei
    Citation: Journal of Translational Medicine 2022 20:319
  44. Increasing evidence indicates that myocardial oxidative injury plays a crucial role in the pathophysiology of cardiac hypertrophy (CH) and heart failure (HF). The active component of rhubarb, rhein exerts sign...

    Authors: Wei Lu, Hongqiao Zhu, Jiawen Wu, Sheng Liao, Guobing Cheng and Xiaoyang Li
    Citation: Journal of Translational Medicine 2022 20:305
  45. Heart failure (HF) is a global leading cause of mortality despite implementation of guideline directed therapy which warrants a need for novel treatment strategies. Proof-of-concept clinical trials of anakinra...

    Authors: Benjamin Van Tassell, Virginia Mihalick, Georgia Thomas, Amr Marawan, Azita H. Talasaz, Juan Lu, Le Kang, Amy Ladd, Juan Ignacio Damonte, Dave L. Dixon, Roshanak Markley, Jeremy Turlington, Emily Federmann, Marco Giuseppe Del Buono, Giuseppe Biondi-Zoccai, Justin M. Canada…
    Citation: Journal of Translational Medicine 2022 20:270
  46. Heart failure (HF), as the leading cause of death, is continuing to increase along with the aging of the general population all over the world. Identification of diagnostic biomarkers for early detection of HF...

    Authors: Lu Qian, Qian Zhao, Ping Yu, Jinhui Lü, Yuefan Guo, Xin Gong, Yuanyuan Ding, Shanshan Yu, Lieying Fan, Huimin Fan, Yuzhen Zhang, Zhongmin Liu, Hongzhuan Sheng and Zuoren Yu
    Citation: Journal of Translational Medicine 2022 20:267
  47. Calcific aortic valve disease (CAVD) is the most commonly valvular disease in the western countries initiated by inflammation and abnormal calcium deposition. Currently, there is no clinical drug for CAVD. Neu...

    Authors: Yan Liu, Peng Jiang, Liqin An, Mengying Zhu, Jin Li, Yue Wang, Qin Huang, Yi Xiang, Xiaorong Li, Qiong Shi and Yaguang Weng
    Citation: Journal of Translational Medicine 2022 20:167
  48. Neointimal hyperplasia induced by interventional surgery can lead to progressive obliteration of the vascular lumen, which has become a major factor affecting prognosis. The rate of re-endothelialization is kn...

    Authors: Lei Li, Yan Gao, Zhenchuan Liu, Chenglai Dong, Wenli Wang, Kaiqin Wu, Shaorui Gu and Yongxin Zhou
    Citation: Journal of Translational Medicine 2022 20:28

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