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Cardiovascular, metabolic and Lipoprotein translation

Section edited by Nehal N. Mehta

This section aims to speed mechanistic understanding, development of novel diagnostics and potential therapeutic targets within cardiovascular, metabolic diseases and lipoprotein diseases. The section is open to experiments involving cellular models, animal models, observational studies and clinical trials that are distinguished for their novelty in approach, design or indication, timeliness, and unique ability to translate laboratory concepts from the bench to the bedside.

Highest priority will be given to those manuscripts which are specifically focused on cardiovascular, metabolic and lipid disorders which enrich understanding of disease mechanism, novel therapeutics and state-of-the-art scientific technique.

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  1. Content type: Research

    MicroRNAs (miRNAs) are non-coding RNAs that function as regulators of gene expression and thereby contribute to the complex disease phenotypes. Hypertrophic cardiomyopathy (HCM) and Dilated cardiomyopathy (DCM...

    Authors: Mengmeng Li, Xiao Chen, Liang Chen, Kai Chen, Jianye Zhou and Jiangping Song

    Citation: Journal of Translational Medicine 2018 16:161

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  2. Content type: Research

    Scavenger receptor class B type I (SR-BI) plays a key role in high density lipoproteins (HDL) metabolism. SR-BI deficiency in mice results in enhanced susceptibility to atherosclerosis with abnormal large, cho...

    Authors: Jia Cao, Yanyong Xu, Feifei Li, Liang Shang, Daping Fan and Hong Yu

    Citation: Journal of Translational Medicine 2018 16:155

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  3. Content type: Research

    Discoidin domain receptor 1 (DDR1) is a collagen-activated receptor tyrosine kinase extensively implicated in diseases such as cancer, atherosclerosis and fibrosis. Multiple preclinical studies, performed usin...

    Authors: Solange Moll, Yukari Yasui, Ahmed Abed, Takeshi Murata, Hideaki Shimada, Akira Maeda, Naoshi Fukushima, Masakazu Kanamori, Sabine Uhles, Laura Badi, Thomas Cagarelli, Ivan Formentini, Faye Drawnel, Guy Georges, Tobias Bergauer, Rodolfo Gasser…

    Citation: Journal of Translational Medicine 2018 16:148

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  4. Content type: Research

    Oxidative stress has been linked to heart failure (HF) in humans. Antioxidant-based treatments are often ineffective. Therefore, we hypothesize that some of the HF patients might have a reductive stress (RS) c...

    Authors: Thiagarajan Sairam, Amit N. Patel, Meenu Subrahmanian, Rajendiran Gopalan, Steven M. Pogwizd, Sudha Ramalingam, Ramalingam Sankaran and Namakkal Soorapan Rajasekaran

    Citation: Journal of Translational Medicine 2018 16:130

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  5. Content type: Review

    The human immunodeficiency virus (HIV) is a major global public health issue. HIV-related cardiovascular disease remains a leading cause of morbidity and mortality in HIV positive patients. HIV Tat is a regula...

    Authors: Yanan Jiang, Lu Chai, Moyondafoluwa Blessing Fasae and Yunlong Bai

    Citation: Journal of Translational Medicine 2018 16:121

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  6. Content type: Research

    Preclinical and proof-of-concept studies suggest a cardioprotective effect of remote ischemic preconditioning (RIPC). However, two major clinical trials (ERICCA and RIPHeart) failed to show cardioprotection by...

    Authors: André Heinen, Friederike Behmenburg, Aykut Aytulun, Maximilian Dierkes, Lea Zerbin, Wolfgang Kaisers, Maximilian Schaefer, Tanja Meyer-Treschan, Susanne Feit, Inge Bauer, Markus W. Hollmann and Ragnar Huhn

    Citation: Journal of Translational Medicine 2018 16:112

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  7. Content type: Research

    The aim of this study was to characterize the influence of cardiopulmonary bypass (CPB) on myocardial remodeling in newborns and children.

    Authors: Johannes Petersen, Andrey Kazakov, Michael Böhm, Hans-Joachim Schäfers, Ulrich Laufs and Hashim Abdul-Khaliq

    Citation: Journal of Translational Medicine 2018 16:111

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  8. Content type: Research

    Intermittent hypoxia (IH), a typical character of obstructive sleep apnea (OSA), is related to atherogenesis. However, the role of IH on atherosclerosis (AS) progression and the mechanisms involved remains poo...

    Authors: Xianqin Zeng, Rong Guo, Mei Dong, Julia Zheng, Huili Lin and Huixia Lu

    Citation: Journal of Translational Medicine 2018 16:106

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  9. Content type: Research

    Perivascular adipose tissue (PVAT) accelerates plaque progression and increases cardiovascular risk. We tested the hypothesis that PVAT contributed to plaque vulnerability and investigated whether endoplasmic ...

    Authors: Ru Ying, Sheng-Wei Li, Jia-Yuan Chen, Hai-Feng Zhang, Ying Yang, Zhen-Jie Gu, Yang-Xin Chen and Jing-Feng Wang

    Citation: Journal of Translational Medicine 2018 16:105

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  10. Content type: Research

    Cardiovascular disease (CVD) describes the pathological conditions of the heart and blood vessels. Despite the large number of studies on CVD and its etiology, its key modulators remain largely unknown. To thi...

    Authors: Vasiliki Lygirou, Agnieszka Latosinska, Manousos Makridakis, William Mullen, Christian Delles, Joost P. Schanstra, Jerome Zoidakis, Burkert Pieske, Harald Mischak and Antonia Vlahou

    Citation: Journal of Translational Medicine 2018 16:104

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  11. Content type: Research

    MicroRNAs (miRNAs) are small RNAs regulating gene expression post-transcriptionally. While acquired changes of miRNA and mRNA profiles in cancer have been extensively studied, little is known about expression ...

    Authors: Masood Abu-Halima, Mustafa Kahraman, Dominic Henn, Tanja Rädle-Hurst, Andreas Keller, Hashim Abdul-Khaliq and Eckart Meese

    Citation: Journal of Translational Medicine 2018 16:60

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  12. Content type: Research

    There is a preponderance of evidence implicating diabetes with increased coronary artery disease (CAD) and calcification (CAC) in human patients with metabolic syndrome (MetS), but the effect of diabetes on CA...

    Authors: Jill K. Badin, Ayeeshik Kole, Benjamin Stivers, Victor Progar, Anisha Pareddy, Mouhamad Alloosh and Michael Sturek

    Citation: Journal of Translational Medicine 2018 16:58

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  13. Content type: Research

    Familial hypercholesterolemia (FH) is a genetic disorder that result in abnormally high low-density lipoprotein cholesterol levels, markedly increased risk of coronary heart disease (CHD) and tendon xanthomas ...

    Authors: Lucía Baila-Rueda, Itziar Lamiquiz-Moneo, Estíbaliz Jarauta, Rocío Mateo-Gallego, Sofía Perez-Calahorra, Victoria Marco-Benedí, Ana M. Bea, Ana Cenarro and Fernando Civeira

    Citation: Journal of Translational Medicine 2018 16:6

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  14. Content type: Research

    Metabolic syndrome (MetS) is a highly prevalent condition that identifies individuals at risk for type 2 diabetes mellitus and atherosclerotic cardiovascular disease. Prevention of these diseases relies on ear...

    Authors: Michelle D. Robinson, Ina Mishra, Sneha Deodhar, Vipulkumar Patel, Katrina V. Gordon, Raul Vintimilla, Kim Brown, Leigh Johnson, Sid O’Bryant and David P. Cistola

    Citation: Journal of Translational Medicine 2017 15:258

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  15. Content type: Review

    Spondylarthritis (SpA) is an inflammatory rheumatic disease associated with increased incidence of major adverse cardiovascular events (MACEs). Recently, Paramarta et al. proposed the use of the tyrosine kinas...

    Authors: Loukman Omarjee, Vincent Jaquinandi and Guillaume Mahe

    Citation: Journal of Translational Medicine 2017 15:255

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  16. Content type: Research

    Image-guided high intensity focused ultrasound has been used as an extracorporeal cardiac pacing tool and to enhance homing of stem cells to targeted tissues. However, molecular changes in the myocardium after...

    Authors: Kee W. Jang, Tsang-Wei Tu, Matthew E. Nagle, Bobbi K. Lewis, Scott R. Burks and Joseph A. Frank

    Citation: Journal of Translational Medicine 2017 15:252

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  17. Content type: Review

    GlycA is a novel spectroscopic marker of systemic inflammation with low intra-individual variability and other attributes favoring its clinical use in patients with chronic inflammatory and autoimmune diseases...

    Authors: Margery A. Connelly, James D. Otvos, Irina Shalaurova, Martin P. Playford and Nehal N. Mehta

    Citation: Journal of Translational Medicine 2017 15:219

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  18. Content type: Research

    Ex-vivo normothermic perfusion strategies are a promising new instrument in organ transplantation. The perfusion conditions are designed to be protective however the artificial environment can induce a local i...

    Authors: Sarah A. Hosgood, Tom Moore, Theresa Kleverlaan, Tom Adams and Michael L. Nicholson

    Citation: Journal of Translational Medicine 2017 15:216

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  19. Content type: Research

    Renal denervation (RDN) is a promising therapeutic method in cardiology. Its currently most investigated indication is resistant hypertension. Other potential indications are atrial fibrillation, type 2 diabet...

    Authors: Jean-Claude Lubanda, Miroslav Chochola, Mikuláš Mlček, Petr Neužil, Josef Marek, Štěpán Havránek, Sylvie Kuchynková, Zdeňka Fingrová, Kao-Hsuan Aimee Huang and Aleš Linhart

    Citation: Journal of Translational Medicine 2017 15:215

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  20. Content type: Research

    Meaningful translational large animal models for cardiac diseases are indispensable for studying disease mechanisms, development of novel therapeutic strategies, and evaluation of potential drugs.

    Authors: Mariann Gyöngyösi, Noemi Pavo, Dominika Lukovic, Katrin Zlabinger, Andreas Spannbauer, Denise Traxler, Georg Goliasch, Ljubica Mandic, Jutta Bergler-Klein, Alfred Gugerell, Andras Jakab, Zsuzsanna Szankai, Levente Toth, Rita Garamvölgyi, Gerald Maurer, Frederic Jaisser…

    Citation: Journal of Translational Medicine 2017 15:202

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