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Translational Genomics and Genetics

Section edited by Wei Liu

This section aims to provide a translational medicine forum for the publication of research on novel genomics assays that leads to better clinical diagnosis and treatment. The core mission of translational genomics and genetics is to delineate the complex interactions among genes, gene products, and the environment. The big genomic dataset, such as the one generated by The Cancer Genome Atlas Program, has a profound impact on scientific discovery and innovation in diagnosis, drug development, and disease management. We are at the edge of superior precision and personalized medicine era. This section is an answer to the call of accelerating translation of genomic technology for better clinical care.

Studies on all aspects of genomic applications in clinical medicine will be considered for publication. The section welcomes interdisciplinary works that related to diagnosis or management of rare genetic disease, complex inherited disease, prenatal/perinatal screening, oncology, organ transplantation, and pathogen identification.

  1. Content type: Research

    Pemetrexed combined with platinum complexes can be used as first-line treatment for advanced non-squamous non-small cell lung cancer (NSCLC), however, the efficacy and safety is varying from individuals. There...

    Authors: Xiaohong Han, Ying Han, Qiaoyun Tan, Yu Huang, Jianliang Yang, Sheng Yang, Xiaohui He, Shengyu Zhou, Yan Song, Jinping Pi, Lijie Zuo, Jiarui Yao, Di Wu, Zhishang Zhang and Yuankai Shi

    Citation: Journal of Translational Medicine 2019 17:339

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  2. Content type: Research

    Monitoring circulating tumor cells (CTC) has been shown to be prognostic in most solid malignancies. There is no CTC assay in clinical use for lung cancer therapy monitoring due to inconclusive clinical utilit...

    Authors: Stephanie N. Shishido, Anders Carlsson, Jorge Nieva, Kelly Bethel, James B. Hicks, Lyudmila Bazhenova and Peter Kuhn

    Citation: Journal of Translational Medicine 2019 17:294

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  3. Content type: Research

    Meningitis can be caused by several viruses and bacteria. Identifying the causative pathogen as quickly as possible is crucial to initiate the most optimal therapy, as acute bacterial meningitis is associated ...

    Authors: Esther Bartholomeus, Nicolas De Neuter, Annelies Lemay, Luc Pattyn, David Tuerlinckx, David Weynants, Koen Van Lede, Gerlant van Berlaer, Dominique Bulckaert, Tine Boiy, Ann Vander Auwera, Marc Raes, Dimitri Van der Linden, Helene Verhelst, Susanne Van Steijn, Tijl Jonckheer…

    Citation: Journal of Translational Medicine 2019 17:282

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  4. Content type: Review

    Infertility is considered a major public health issue, and approximately 1 out of 6 people worldwide suffer from infertility during their reproductive lifespans. Thanks to technological advances, genetic tests...

    Authors: Federica Cariati, Valeria D’Argenio and Rossella Tomaiuolo

    Citation: Journal of Translational Medicine 2019 17:267

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  5. Content type: Research

    Alloantibodies against human platelet antigens (HPAs) and human leukocyte antigen (HLA) are implicated in several immune-mediated platelet disorders. Detection of these antibodies is crucial in the diagnosis a...

    Authors: Sudan Tao, Shu Chen, Xiaozhen Hong, Ji He and Faming Zhu

    Citation: Journal of Translational Medicine 2019 17:249

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  6. Content type: Research

    The use of one-step nucleic acid amplification (OSNA) allows for lymph node (LN) metastasis to be detected rapidly and accurately. We conducted a prospective single-centre clinical trial to evaluate OSNA assay...

    Authors: María Escalante Pérez, María Teresa Hermida Romero, Begoña Otero Alén, Mónica Álvarez Martínez, Ricardo Fernández Prado, Mercedes de la Torre Bravos and Ángel Concha López

    Citation: Journal of Translational Medicine 2019 17:233

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