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Translational Imaging

Section edited by Ravinder Reddy and Mohammed Haris

The Translational Imaging section provides a platform for rapid dissemination of the advances in medical imaging research emphasizing clinical translation. The topics covered in this section will include methodological innovations in early diagnoses of human diseases and monitoring of therapeutic responses from all the major imaging modalities (MRI, PET, US etc.,). Articles considered for publication include studies in human subjects, pre-clinical models and ex vivo systems dealing with imaging of human pathophysiologies.

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  1. Stratification of DNA mismatch repair (MMR) status in patients with colorectal cancer (CRC) enables individual clinical treatment decision making. The present study aimed to develop and validate a deep learnin...

    Authors: Wuteng Cao, Huabin Hu, Jirui Guo, Qiyuan Qin, Yanbang Lian, Jiao Li, Qianyu Wu, Junhong Chen, Xinhua Wang and Yanhong Deng
    Citation: Journal of Translational Medicine 2023 21:214
  2. Identifying predictive non-invasive biomarkers of immunotherapy response is crucial to avoid premature treatment interruptions or ineffective prolongation. Our aim was to develop a non-invasive biomarker for p...

    Authors: Benito Farina, Ana Delia Ramos Guerra, David Bermejo-Peláez, Carmelo Palacios Miras, Andrés Alcazar Peral, Guillermo Gallardo Madueño, Jesús Corral Jaime, Anna Vilalta-Lacarra, Jaime Rubio Pérez, Arrate Muñoz-Barrutia, German R. Peces-Barba, Luis Seijo Maceiras, Ignacio Gil-Bazo, Manuel Dómine Gómez and María J. Ledesma-Carbayo
    Citation: Journal of Translational Medicine 2023 21:174
  3. 18F-fluorodeoxyglucose positron emission tomography (18F-FDG PET) identifies carotid plaque inflammation and predicts stroke recurrence.

    Authors: Eduardo Garcia, Pol Camps-Renom, Núria Puig, Alejandro Fernández-Leon, Ana Aguilera-Simón, Aleyda Benitez-Amaro, Arnau Solé, David Vilades, José Luis Sanchez-Quesada, Joan Martí-Fàbregas, Elena Jiménez-Xarrié, Sonia Benitez and Vicenta Llorente-Cortés
    Citation: Journal of Translational Medicine 2023 21:131
  4. Ki-67 labeling index (LI) is an important indicator of tumor cell proliferation in glioma, which can only be obtained by postoperative biopsy at present. This study aimed to explore the correlation between Ki-...

    Authors: Ningfang Du, Weiquan Shu, Kefeng Li, Yao Deng, Xinxin Xu, Yao Ye, Feng Tang, Renling Mao, Guangwu Lin, Shihong Li and Xuhao Fang
    Citation: Journal of Translational Medicine 2023 21:119
  5. Human epidermal growth factor receptor 2 (HER2) overexpressed associated with poor prognosis in breast cancer and HER2 has been defined as a therapeutic target for breast cancer treatment. We aimed to explore ...

    Authors: Hao Cui, Yue Sun, Dantong Zhao, Xudong Zhang, Hanqing Kong, Nana Hu, Panting Wang, Xiaoxuan Zuo, Wei Fan, Yuan Yao, Baiyang Fu, Jiawei Tian, Meixin Wu, Yue Gao, Shangwei Ning and Lei Zhang
    Citation: Journal of Translational Medicine 2023 21:44
  6. Due to the temporal and spatial heterogeneity of human epidermal growth factor receptor 2 (HER2) expression in breast tumors, immunohistochemistry (IHC) cannot accurately reflect the HER2 status in real time, ...

    Authors: Jiyun Shi, Shuaifan Du, Rongxi Wang, Hannan Gao, Qi Luo, Guozhu Hou, Yidong Zhou, Zhaohui Zhu and Fan Wang
    Citation: Journal of Translational Medicine 2023 21:19
  7. To investigate the association between computed tomography (CT)-detected extramural venous invasion (EMVI)-related genes and immunotherapy resistance and immune escape in patients with gastric cancer (GC).

    Authors: Hao Yang, Xinyi Gou, Caizhen Feng, Yinli Zhang, Fan Chai, Nan Hong, Yingjiang Ye, Yi Wang, Bo Gao and Jin Cheng
    Citation: Journal of Translational Medicine 2023 21:4
  8. Positron Emission Tomography (PET) imaging with Prostate-Specific Membrane Antigen (PSMA) and Fluorodeoxyglucose (FDG) represent promising biomarkers for risk-stratification of Prostate Cancer (PCa). We verifi...

    Authors: Matteo Bauckneht, Cecilia Marini, Vanessa Cossu, Cristina Campi, Mattia Riondato, Silvia Bruno, Anna Maria Orengo, Francesca Vitale, Sonia Carta, Silvia Chiola, Sabrina Chiesa, Alberto Miceli, Francesca D’Amico, Giuseppe Fornarini, Carlo Terrone, Michele Piana…
    Citation: Journal of Translational Medicine 2023 21:3
  9. Early prediction of response to neoadjuvant chemotherapy (NACT) is important to aid personalized treatment in osteosarcoma. Diffusion-weighted Intravoxel Incoherent Motion (IVIM) MRI was used to evaluate the p...

    Authors: Esha Baidya Kayal, Sameer Bakhshi, Devasenathipathy Kandasamy, Mehar Chand Sharma, Shah Alam Khan, Venkatesan Sampath Kumar, Kedar Khare, Raju Sharma and Amit Mehndiratta
    Citation: Journal of Translational Medicine 2022 20:625
  10. This study aimed to develop a radiogenomic prognostic prediction model for colorectal cancer (CRC) by investigating the biological and clinical relevance of intratumoural heterogeneity.

    Authors: Min-Er Zhong, Xin Duan, Ma-yi-di-li Ni-jia-ti, Haoning Qi, Dongwei Xu, Du Cai, Chenghang Li, Zeping Huang, Qiqi Zhu, Feng Gao and Xiaojian Wu
    Citation: Journal of Translational Medicine 2022 20:574
  11. Tumor-infiltrating lymphocytes (TILs) have become a promising biomarker for assessing tumor immune microenvironment and predicting immunotherapy response. However, the assessment of TILs relies on invasive pat...

    Authors: Guan-Hua Su, Yi Xiao, Lin Jiang, Ren-Cheng Zheng, He Wang, Yan Chen, Ya-Jia Gu, Chao You and Zhi-Ming Shao
    Citation: Journal of Translational Medicine 2022 20:471
  12. The aim of this study was to determine the expression and function of heterogeneous nuclear ribonucleoprotein R (HNRNPR) in esophageal carcinoma (ESCA), the correlation between its expression and 18F-fluorodeoxyg...

    Authors: Xiao-Yu Liu, Yan Gao, Xue-Yan Kui, Xu-Sheng Liu, Yao-hua Zhang, Yu Zhang, Chang-Bin Ke and Zhi-Jun Pei
    Citation: Journal of Translational Medicine 2022 20:450
  13. Several new generation CDK4/6 inhibitors have been developed and approved for breast cancer therapy in combination with endocrine therapeutics. Application of these inhibitors either alone or in combination in...

    Authors: James L. Tatum, Joseph D. Kalen, Paula M. Jacobs, Lisa A. Riffle, Amy James, Lai Thang, Chelsea Sanders, Melinda G. Hollingshead, Falguni Basuli, Jianfeng Shi and James H. Doroshow
    Citation: Journal of Translational Medicine 2022 20:375
  14. Although eukaryotic initiation factor 6 (eIF6) is a novel therapeutic target, data on its importance in the development of esophageal carcinoma (ESCA) remains limited. This study evaluated the correlation betw...

    Authors: Yan Gao, Lingling Yuan, Jing Zeng, Fuyan Li, Xiaohui Li, Fan Tan, Xusheng Liu, Huabing Wan, Xueyan Kui, Xiaoyu Liu, Changbin Ke and Zhijun Pei
    Citation: Journal of Translational Medicine 2022 20:303
  15. Prostate cancer (PCa) is the second most prevalent cancer in males worldwide, yet detecting PCa and its metastases remains a major challenging task in clinical research setups. The present study aimed to chara...

    Authors: Xi Zhang, Binbin Xia, Hong Zheng, Jie Ning, Yinjie Zhu, Xiaoguang Shao, Binrui Liu, Baijun Dong and Hongchang Gao
    Citation: Journal of Translational Medicine 2022 20:275
  16. The aim of this study was to compare Dynamic Susceptibility Contrast Enhanced MRI (DSC-MRI) and PET with [18F]flurodeoxyglucose (FDG-PET) in the diagnosis of Alzheimer’s Disease (AD) and amnestic Mild Cognitiv...

    Authors: Aleksandra Wabik, Elżbieta Trypka, Joanna Bladowska, Mikołaj Statkiewicz, Marek Sąsiadek and Anna Zimny
    Citation: Journal of Translational Medicine 2022 20:259
  17. Pantothenate kinase (PANK) is the first and rate-controlling enzymatic step in the only pathway for cellular coenzyme A (CoA) biosynthesis. PANK-associated neurodegeneration (PKAN), formerly known as Hallervor...

    Authors: Yanan Li, Jeffrey Steinberg, Zane Coleman, Shubo Wang, Chitra Subramanian, Yimei Li, Zoltan Patay, Walter Akers, Charles O. Rock, Suzanne Jackowski and Puneet Bagga
    Citation: Journal of Translational Medicine 2022 20:103
  18. Chemoresistance gradually develops during treatment of epithelial ovarian cancer (EOC). Metabolic alterations, especially in vivo easily detectable metabolites in paclitaxel (PTX)-resistant EOC remain unclear.

    Authors: Jing Lu, Ying Li, Yong Ai Li, Li Wang, An Rong Zeng, Xiao Liang Ma and Jin Wei Qiang
    Citation: Journal of Translational Medicine 2022 20:92
  19. To develop and validate a survival model with clinico-biological features and 18F- FDG PET/CT radiomic features via machine learning, and for predicting the prognosis from the primary tumor of colorectal cancer.

    Authors: Lilang Lv, Bowen Xin, Yichao Hao, Ziyi Yang, Junyan Xu, Lisheng Wang, Xiuying Wang, Shaoli Song and Xiaomao Guo
    Citation: Journal of Translational Medicine 2022 20:66
  20. The study investigated the predictive value of tumor angiogenesis observed by 18F-ALF-NOTA-PRGD2 II (denoted as 18F-Alfatide II) positron emission tomography (PET)/computed tomography (CT) before concurrent chemo...

    Authors: Yuchun Wei, Xueting Qin, Xiaoli Liu, Jinsong Zheng, Xiaohui Luan, Yue Zhou, Jinming Yu and Shuanghu Yuan
    Citation: Journal of Translational Medicine 2022 20:63
  21. The prevalence of diffuse-type gastric cancer (GC), especially signet ring cell carcinoma (SRCC), has shown an upward trend in the past decades. This study aimed to develop computed tomography (CT) based radio...

    Authors: Tao Chen, Jing Wu, Chunhui Cui, Qinglie He, Xunjun Li, Weiqi Liang, Xiaoyue Liu, Tianbao Liu, Xuanhui Zhou, Xifan Zhang, Xiaotian Lei, Wei Xiong, Jiang Yu and Guoxin Li
    Citation: Journal of Translational Medicine 2022 20:38
  22. Preoperative diagnosis of pheochromocytoma (PHEO) accurately impacts preoperative preparation and surgical outcome in PHEO patients. Highly reliable model to diagnose PHEO is lacking. We aimed to develop a mag...

    Authors: Jianqiu Kong, Junjiong Zheng, Jieying Wu, Shaoxu Wu, Jinhua Cai, Xiayao Diao, Weibin Xie, Xiong Chen, Hao Yu, Lifang Huang, Hongpeng Fang, Xinxiang Fan, Haide Qin, Yong Li, Zhuo Wu, Jian Huang…
    Citation: Journal of Translational Medicine 2022 20:31
  23. With the high spatial resolution and the potential to reach deep brain structures, ultrasound-based brain stimulation techniques offer new opportunities to non-invasively treat neurological and psychiatric dis...

    Authors: Eva Matt, Lisa Kaindl, Saskia Tenk, Anicca Egger, Teodora Kolarova, Nejla Karahasanović, Ahmad Amini, Andreas Arslan, Kardelen Sariçiçek, Alexandra Weber and Roland Beisteiner
    Citation: Journal of Translational Medicine 2022 20:26
  24. This study aimed to evaluate the utility of radiomics-based machine learning analysis with multiparametric DWI and to compare the diagnostic performance of radiomics features and mean diffusion metrics in the ...

    Authors: Kun Sun, Zhicheng Jiao, Hong Zhu, Weimin Chai, Xu Yan, Caixia Fu, Jie-Zhi Cheng, Fuhua Yan and Dinggang Shen
    Citation: Journal of Translational Medicine 2021 19:443
  25. Cystic fibrosis (CF) patients present with a variety of symptoms, including mood and cognition deficits, in addition to classical respiratory, and autonomic issues. This suggests that brain injury, which can b...

    Authors: Bhaswati Roy, Marlyn S. Woo, Susana Vacas, Patricia Eshaghian, Adupa P. Rao and Rajesh Kumar
    Citation: Journal of Translational Medicine 2021 19:419
  26. Pelvic magnetic resonance imaging (MRI) and whole-body positron emission tomography-computed tomography (PET-CT) play an important role at primary diagnostic work-up and in detecting recurrent disease in endom...

    Authors: Heidi Espedal, Hege F. Berg, Tina Fonnes, Kristine E. Fasmer, Camilla Krakstad and Ingfrid S. Haldorsen
    Citation: Journal of Translational Medicine 2021 19:406
  27. Misdiagnosis of multiple sclerosis (MS) and neuromyelitis optica (NMO) may delay the treatment, resulting in poor prognosis. However, the precise identification of these two diseases is still challenging in cl...

    Authors: Jing Huang, Bowen Xin, Xiuying Wang, Zhigang Qi, Huiqing Dong, Kuncheng Li, Yun Zhou and Jie Lu
    Citation: Journal of Translational Medicine 2021 19:377
  28. Pathological complete response (pCR) is considered a surrogate endpoint for favorable survival in breast cancer patients treated with neoadjuvant chemotherapy (NAC). Predictive biomarkers of treatment response...

    Authors: Fengling Li, Yongquan Yang, Yani Wei, Ping He, Jie Chen, Zhongxi Zheng and Hong Bu
    Citation: Journal of Translational Medicine 2021 19:348
  29. Mental disorders widely contribute to the modern global disease burden, creating a significant need for improvement of treatments. Scalp stimulation methods (such as scalp acupuncture and transcranial electric...

    Authors: Jin Cao, Thalia Celeste Chai-Zhang, Yiting Huang, Maya Nicole Eshel and Jian Kong
    Citation: Journal of Translational Medicine 2021 19:343
  30. Coronavirus disease 2019 (COVID-19) is very contagious. Cases appear faster than the available Polymerase Chain Reaction test kits in many countries. Recently, lung computerized tomography (CT) has been used a...

    Authors: Daryl L. X. Fung, Qian Liu, Judah Zammit, Carson Kai-Sang Leung and Pingzhao Hu
    Citation: Journal of Translational Medicine 2021 19:318
  31. Appropriate structural and material properties are essential for finite-element-modeling (FEM). In knee FEM, structural information could extract through 3D-imaging, but the individual subject’s tissue materia...

    Authors: Sandeep Panwar Jogi, Rafeek Thaha, Sriram Rajan, Vidur Mahajan, Vasantha Kumar Venugopal, Anup Singh and Amit Mehndiratta
    Citation: Journal of Translational Medicine 2021 19:310
  32. Panic disorder (PD) is thought to be related with deficits in emotion regulation, especially in cognitive reappraisal. According to the cognitive model, PD patients’ intrinsic and unconscious misappraisal stra...

    Authors: Hai-Yang Wang, Guo-Qing Xu, Ming-Fei Ni, Cui-Hong Zhang, Xue-Lin Li, Yi Chang, Xiao-Pei Sun and Bing-Wei Zhang
    Citation: Journal of Translational Medicine 2021 19:304
  33. Nonradiographic axial spondyloarthropathies (nr-axSpA) are diagnosed by the absence of radiographic sacroiliitis and the presence of bone marrow edema (BME) on magnetic resonance imaging (MRI). According to th...

    Authors: Chun-Chi Lu, Guo-Shu Huang, Tony Szu-Hsien Lee, En Chao, Hsiang-Cheng Chen, Yong-Si Guo, Shi-Jye Chu, Feng-Cheng Liu, San-Yuan Kao, Tsung-Yun Hou, Chen-Hung Chen, Deh-Ming Chang and Sin-Yi Lyu
    Citation: Journal of Translational Medicine 2021 19:298
  34. To investigate the performance of diffusion-weighted (DW) MRI with mono-, bi- and stretched-exponential models in predicting pathologic complete response (pCR) to neoadjuvant chemotherapy (NACT) for breast can...

    Authors: Shiteng Suo, Yan Yin, Xiaochuan Geng, Dandan Zhang, Jia Hua, Fang Cheng, Jie Chen, Zhiguo Zhuang, Mengqiu Cao and Jianrong Xu
    Citation: Journal of Translational Medicine 2021 19:236
  35. The phytocannabinoid cannabidiol (CBD) exhibits anxiolytic activity and has been promoted as a potential treatment for post-traumatic stress disorders. How does CBD interact with the brain to alter behavior? W...

    Authors: Aymen H. Sadaka, Ana G. Ozuna, Richard J. Ortiz, Praveen Kulkarni, Clare T. Johnson, Heather B. Bradshaw, Bruce S. Cushing, Ai-Ling Li, Andrea G. Hohmann and Craig F. Ferris
    Citation: Journal of Translational Medicine 2021 19:220
  36. The timeliness of diagnostic testing after positive screening remains suboptimal because of limited evidence and methodology, leading to delayed diagnosis of lung cancer and over-examination. We propose a radi...

    Authors: Zixing Wang, Ning Li, Fuling Zheng, Xin Sui, Wei Han, Fang Xue, Xiaoli Xu, Cuihong Yang, Yaoda Hu, Lei Wang, Wei Song and Jingmei Jiang
    Citation: Journal of Translational Medicine 2021 19:191
  37. Myopic maculopathy (MM) is the most serious and irreversible complication of pathologic myopia, which is a major cause of visual impairment and blindness. Clinic proposed limited number of factors related to M...

    Authors: Yuchen Du, Qiuying Chen, Ying Fan, Jianfeng Zhu, Jiangnan He, Haidong Zou, Dazhen Sun, Bowen Xin, David Feng, Michael Fulham, Xiuying Wang, Lisheng Wang and Xun Xu
    Citation: Journal of Translational Medicine 2021 19:167

    The Correction to this article has been published in Journal of Translational Medicine 2021 19:203

  38. Limited data was available for rapid and accurate detection of COVID-19 using CT-based machine learning model. This study aimed to investigate the value of chest CT radiomics for diagnosing COVID-19 pneumonia ...

    Authors: Huanhuan Liu, Hua Ren, Zengbin Wu, He Xu, Shuhai Zhang, Jinning Li, Liang Hou, Runmin Chi, Hui Zheng, Yanhong Chen, Shaofeng Duan, Huimin Li, Zongyu Xie and Dengbin Wang
    Citation: Journal of Translational Medicine 2021 19:29
  39. Diffuse intrinsic pontine glioma (DIPG) is the most common brainstem cancer in childhood. This rapidly progressing brainstem glioma holds a very dismal prognosis with median survival of less than 1 year. Despi...

    Authors: Lincy Thomas, Nataliya Smith, Debra Saunders, Michelle Zalles, Rafal Gulej, Megan Lerner, Kar-Ming Fung, Angel M. Carcaboso and Rheal A. Towner
    Citation: Journal of Translational Medicine 2020 18:424
  40. Since the first case of a coronavirus disease 2019 (COVID-19) infection pneumonia was detected in Wuhan, China, a series of confirmed cases of the COVID-19 were found in Southwest China. The aim of this study ...

    Authors: Xiaoming Li, Wenbing Zeng, Xiang Li, Haonan Chen, Linping Shi, Xinghui Li, Hongnian Xiang, Yang Cao, Hui Chen, Chen Liu and Jian Wang
    Citation: Journal of Translational Medicine 2020 18:154
  41. Lupus nephritis is one of the most common and severe complications of systemic lupus erythematosus, of which poor prognosis is indicated by aggravated renal hypoxia and tubulointerstitial fibrosis. Cell adhesi...

    Authors: Liwen Zhang, Sheng Chen, Yan Liu, Xueqin Xu, Qianying Zhang, Shuxin Shao, Weiming Wang and Xiao Li
    Citation: Journal of Translational Medicine 2020 18:116
  42. There is a lack of well-established clinical tools for predicting dendritic cell (DC) vaccination response of pancreatic ductal adenocarcinoma (PDAC). DC vaccine treatment efficiency was demonstrated using his...

    Authors: Aydin Eresen, Jia Yang, Junjie Shangguan, Yu Li, Su Hu, Chong Sun, Yury Velichko, Vahid Yaghmai, Al B. Benson III and Zhuoli Zhang
    Citation: Journal of Translational Medicine 2020 18:61
  43. The temporomandibular joint (TMJ) is well innervated by braches of the trigeminal nerve. The temporomandibular joint disorders (TMD) can cause neural-inflammation in the peripheral nervous system (PNS) at the ...

    Authors: Andre Barkhordarian, Gary Demerjian and Francesco Chiappelli
    Citation: Journal of Translational Medicine 2020 18:22
  44. Spontaneously metastatic xenograft models of cancer are infrequent and the few that exist are resource intensive. In xenografts, caliper measurements can be used to determine primary tumor burden and response ...

    Authors: James L. Tatum, Joseph D. Kalen, Paula M. Jacobs, Lilia V. Ileva, Lisa A. Riffle, Melinda G. Hollingshead and James H. Doroshow
    Citation: Journal of Translational Medicine 2019 17:425
  45. Secondary and retrospective use of hospital-hosted clinical data provides a time- and cost-efficient alternative to prospective clinical trials for biomarker development. This study aims to create a retrospect...

    Authors: Rebecca J. Weiss, Sara V. Bates, Ya’nan Song, Yue Zhang, Emily M. Herzberg, Yih-Chieh Chen, Maryann Gong, Isabel Chien, Lily Zhang, Shawn N. Murphy, Randy L. Gollub, P. Ellen Grant and Yangming Ou
    Citation: Journal of Translational Medicine 2019 17:385
  46. To evaluate the imaging biomarkers of human epidermal growth factor receptor 2 (HER2) positive breast cancer in comparison to other molecular subtypes and to determine the feasibility of identifying hormone re...

    Authors: Chao You, Jianwei Li, Wenxiang Zhi, Yanqiong Chen, Wentao Yang, Yajia Gu and Weijun Peng
    Citation: Journal of Translational Medicine 2019 17:182
  47. Gene transfer to malignant sites using human adenoviruses (hAds) has been limited because of their immunogenic nature and host specificity. Murine cells often lack some of the receptors needed for hAds attachm...

    Authors: Flavia De Carlo, Litty Thomas, Bell Brooke, Elliot T. Varney, Rounak Nande, Olivia Boskovic, Gailen D. Marshall, Pier Paolo Claudio and Candace M. Howard
    Citation: Journal of Translational Medicine 2019 17:19
  48. Breast cancer surgeons struggle with differentiating healthy tissue from cancer at the resection margin during surgery. We report on the feasibility of using diffuse reflectance spectroscopy (DRS) for real-tim...

    Authors: Lisanne L. de Boer, Torre M. Bydlon, Frederieke van Duijnhoven, Marie-Jeanne T. F. D. Vranken Peeters, Claudette E. Loo, Gonneke A. O. Winter-Warnars, Joyce Sanders, Henricus J. C. M. Sterenborg, Benno H. W. Hendriks and Theo J. M. Ruers
    Citation: Journal of Translational Medicine 2018 16:367

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