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Translational Imaging

Section edited by Ravinder Reddy and Mohammed Haris

The Translational Imaging section provides a platform for rapid dissemination of the advances in medical imaging research emphasizing clinical translation. The topics covered in this section will include methodological innovations in early diagnoses of human diseases and monitoring of therapeutic responses from all the major imaging modalities (MRI, PET, US etc.,). Articles considered for publication include studies in human subjects, pre-clinical models and ex vivo systems dealing with imaging of human pathophysiologies.

  1. This study aimed to evaluate the utility of radiomics-based machine learning analysis with multiparametric DWI and to compare the diagnostic performance of radiomics features and mean diffusion metrics in the ...

    Authors: Kun Sun, Zhicheng Jiao, Hong Zhu, Weimin Chai, Xu Yan, Caixia Fu, Jie-Zhi Cheng, Fuhua Yan and Dinggang Shen

    Citation: Journal of Translational Medicine 2021 19:443

    Content type: Research

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  2. Cystic fibrosis (CF) patients present with a variety of symptoms, including mood and cognition deficits, in addition to classical respiratory, and autonomic issues. This suggests that brain injury, which can b...

    Authors: Bhaswati Roy, Marlyn S. Woo, Susana Vacas, Patricia Eshaghian, Adupa P. Rao and Rajesh Kumar

    Citation: Journal of Translational Medicine 2021 19:419

    Content type: Research

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  3. Pelvic magnetic resonance imaging (MRI) and whole-body positron emission tomography-computed tomography (PET-CT) play an important role at primary diagnostic work-up and in detecting recurrent disease in endom...

    Authors: Heidi Espedal, Hege F. Berg, Tina Fonnes, Kristine E. Fasmer, Camilla Krakstad and Ingfrid S. Haldorsen

    Citation: Journal of Translational Medicine 2021 19:406

    Content type: Research

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  4. Misdiagnosis of multiple sclerosis (MS) and neuromyelitis optica (NMO) may delay the treatment, resulting in poor prognosis. However, the precise identification of these two diseases is still challenging in cl...

    Authors: Jing Huang, Bowen Xin, Xiuying Wang, Zhigang Qi, Huiqing Dong, Kuncheng Li, Yun Zhou and Jie Lu

    Citation: Journal of Translational Medicine 2021 19:377

    Content type: Research

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  5. Pathological complete response (pCR) is considered a surrogate endpoint for favorable survival in breast cancer patients treated with neoadjuvant chemotherapy (NAC). Predictive biomarkers of treatment response...

    Authors: Fengling Li, Yongquan Yang, Yani Wei, Ping He, Jie Chen, Zhongxi Zheng and Hong Bu

    Citation: Journal of Translational Medicine 2021 19:348

    Content type: Research

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  6. Mental disorders widely contribute to the modern global disease burden, creating a significant need for improvement of treatments. Scalp stimulation methods (such as scalp acupuncture and transcranial electric...

    Authors: Jin Cao, Thalia Celeste Chai-Zhang, Yiting Huang, Maya Nicole Eshel and Jian Kong

    Citation: Journal of Translational Medicine 2021 19:343

    Content type: Research

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  7. Coronavirus disease 2019 (COVID-19) is very contagious. Cases appear faster than the available Polymerase Chain Reaction test kits in many countries. Recently, lung computerized tomography (CT) has been used a...

    Authors: Daryl L. X. Fung, Qian Liu, Judah Zammit, Carson Kai-Sang Leung and Pingzhao Hu

    Citation: Journal of Translational Medicine 2021 19:318

    Content type: Research

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  8. Appropriate structural and material properties are essential for finite-element-modeling (FEM). In knee FEM, structural information could extract through 3D-imaging, but the individual subject’s tissue materia...

    Authors: Sandeep Panwar Jogi, Rafeek Thaha, Sriram Rajan, Vidur Mahajan, Vasantha Kumar Venugopal, Anup Singh and Amit Mehndiratta

    Citation: Journal of Translational Medicine 2021 19:310

    Content type: Research

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  9. Panic disorder (PD) is thought to be related with deficits in emotion regulation, especially in cognitive reappraisal. According to the cognitive model, PD patients’ intrinsic and unconscious misappraisal stra...

    Authors: Hai-Yang Wang, Guo-Qing Xu, Ming-Fei Ni, Cui-Hong Zhang, Xue-Lin Li, Yi Chang, Xiao-Pei Sun and Bing-Wei Zhang

    Citation: Journal of Translational Medicine 2021 19:304

    Content type: Research

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  10. Nonradiographic axial spondyloarthropathies (nr-axSpA) are diagnosed by the absence of radiographic sacroiliitis and the presence of bone marrow edema (BME) on magnetic resonance imaging (MRI). According to th...

    Authors: Chun-Chi Lu, Guo-Shu Huang, Tony Szu-Hsien Lee, En Chao, Hsiang-Cheng Chen, Yong-Si Guo, Shi-Jye Chu, Feng-Cheng Liu, San-Yuan Kao, Tsung-Yun Hou, Chen-Hung Chen, Deh-Ming Chang and Sin-Yi Lyu

    Citation: Journal of Translational Medicine 2021 19:298

    Content type: Research

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  11. To investigate the performance of diffusion-weighted (DW) MRI with mono-, bi- and stretched-exponential models in predicting pathologic complete response (pCR) to neoadjuvant chemotherapy (NACT) for breast can...

    Authors: Shiteng Suo, Yan Yin, Xiaochuan Geng, Dandan Zhang, Jia Hua, Fang Cheng, Jie Chen, Zhiguo Zhuang, Mengqiu Cao and Jianrong Xu

    Citation: Journal of Translational Medicine 2021 19:236

    Content type: Research

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  12. The phytocannabinoid cannabidiol (CBD) exhibits anxiolytic activity and has been promoted as a potential treatment for post-traumatic stress disorders. How does CBD interact with the brain to alter behavior? W...

    Authors: Aymen H. Sadaka, Ana G. Ozuna, Richard J. Ortiz, Praveen Kulkarni, Clare T. Johnson, Heather B. Bradshaw, Bruce S. Cushing, Ai-Ling Li, Andrea G. Hohmann and Craig F. Ferris

    Citation: Journal of Translational Medicine 2021 19:220

    Content type: Research

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  13. The timeliness of diagnostic testing after positive screening remains suboptimal because of limited evidence and methodology, leading to delayed diagnosis of lung cancer and over-examination. We propose a radi...

    Authors: Zixing Wang, Ning Li, Fuling Zheng, Xin Sui, Wei Han, Fang Xue, Xiaoli Xu, Cuihong Yang, Yaoda Hu, Lei Wang, Wei Song and Jingmei Jiang

    Citation: Journal of Translational Medicine 2021 19:191

    Content type: Research

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  14. Myopic maculopathy (MM) is the most serious and irreversible complication of pathologic myopia, which is a major cause of visual impairment and blindness. Clinic proposed limited number of factors related to M...

    Authors: Yuchen Du, Qiuying Chen, Ying Fan, Jianfeng Zhu, Jiangnan He, Haidong Zou, Dazhen Sun, Bowen Xin, David Feng, Michael Fulham, Xiuying Wang, Lisheng Wang and Xun Xu

    Citation: Journal of Translational Medicine 2021 19:167

    Content type: Research

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    The Correction to this article has been published in Journal of Translational Medicine 2021 19:203

  15. Limited data was available for rapid and accurate detection of COVID-19 using CT-based machine learning model. This study aimed to investigate the value of chest CT radiomics for diagnosing COVID-19 pneumonia ...

    Authors: Huanhuan Liu, Hua Ren, Zengbin Wu, He Xu, Shuhai Zhang, Jinning Li, Liang Hou, Runmin Chi, Hui Zheng, Yanhong Chen, Shaofeng Duan, Huimin Li, Zongyu Xie and Dengbin Wang

    Citation: Journal of Translational Medicine 2021 19:29

    Content type: Research

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  16. Diffuse intrinsic pontine glioma (DIPG) is the most common brainstem cancer in childhood. This rapidly progressing brainstem glioma holds a very dismal prognosis with median survival of less than 1 year. Despi...

    Authors: Lincy Thomas, Nataliya Smith, Debra Saunders, Michelle Zalles, Rafal Gulej, Megan Lerner, Kar-Ming Fung, Angel M. Carcaboso and Rheal A. Towner

    Citation: Journal of Translational Medicine 2020 18:424

    Content type: Research

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  17. Since the first case of a coronavirus disease 2019 (COVID-19) infection pneumonia was detected in Wuhan, China, a series of confirmed cases of the COVID-19 were found in Southwest China. The aim of this study ...

    Authors: Xiaoming Li, Wenbing Zeng, Xiang Li, Haonan Chen, Linping Shi, Xinghui Li, Hongnian Xiang, Yang Cao, Hui Chen, Chen Liu and Jian Wang

    Citation: Journal of Translational Medicine 2020 18:154

    Content type: Research

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  18. Lupus nephritis is one of the most common and severe complications of systemic lupus erythematosus, of which poor prognosis is indicated by aggravated renal hypoxia and tubulointerstitial fibrosis. Cell adhesi...

    Authors: Liwen Zhang, Sheng Chen, Yan Liu, Xueqin Xu, Qianying Zhang, Shuxin Shao, Weiming Wang and Xiao Li

    Citation: Journal of Translational Medicine 2020 18:116

    Content type: Research

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  19. There is a lack of well-established clinical tools for predicting dendritic cell (DC) vaccination response of pancreatic ductal adenocarcinoma (PDAC). DC vaccine treatment efficiency was demonstrated using his...

    Authors: Aydin Eresen, Jia Yang, Junjie Shangguan, Yu Li, Su Hu, Chong Sun, Yury Velichko, Vahid Yaghmai, Al B. Benson III and Zhuoli Zhang

    Citation: Journal of Translational Medicine 2020 18:61

    Content type: Research

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  20. The temporomandibular joint (TMJ) is well innervated by braches of the trigeminal nerve. The temporomandibular joint disorders (TMD) can cause neural-inflammation in the peripheral nervous system (PNS) at the ...

    Authors: Andre Barkhordarian, Gary Demerjian and Francesco Chiappelli

    Citation: Journal of Translational Medicine 2020 18:22

    Content type: Research

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  21. Spontaneously metastatic xenograft models of cancer are infrequent and the few that exist are resource intensive. In xenografts, caliper measurements can be used to determine primary tumor burden and response ...

    Authors: James L. Tatum, Joseph D. Kalen, Paula M. Jacobs, Lilia V. Ileva, Lisa A. Riffle, Melinda G. Hollingshead and James H. Doroshow

    Citation: Journal of Translational Medicine 2019 17:425

    Content type: Methodology

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  22. Secondary and retrospective use of hospital-hosted clinical data provides a time- and cost-efficient alternative to prospective clinical trials for biomarker development. This study aims to create a retrospect...

    Authors: Rebecca J. Weiss, Sara V. Bates, Ya’nan Song, Yue Zhang, Emily M. Herzberg, Yih-Chieh Chen, Maryann Gong, Isabel Chien, Lily Zhang, Shawn N. Murphy, Randy L. Gollub, P. Ellen Grant and Yangming Ou

    Citation: Journal of Translational Medicine 2019 17:385

    Content type: Protocol

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  23. To evaluate the imaging biomarkers of human epidermal growth factor receptor 2 (HER2) positive breast cancer in comparison to other molecular subtypes and to determine the feasibility of identifying hormone re...

    Authors: Chao You, Jianwei Li, Wenxiang Zhi, Yanqiong Chen, Wentao Yang, Yajia Gu and Weijun Peng

    Citation: Journal of Translational Medicine 2019 17:182

    Content type: Research

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  24. Gene transfer to malignant sites using human adenoviruses (hAds) has been limited because of their immunogenic nature and host specificity. Murine cells often lack some of the receptors needed for hAds attachm...

    Authors: Flavia De Carlo, Litty Thomas, Bell Brooke, Elliot T. Varney, Rounak Nande, Olivia Boskovic, Gailen D. Marshall, Pier Paolo Claudio and Candace M. Howard

    Citation: Journal of Translational Medicine 2019 17:19

    Content type: Research

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  25. Breast cancer surgeons struggle with differentiating healthy tissue from cancer at the resection margin during surgery. We report on the feasibility of using diffuse reflectance spectroscopy (DRS) for real-tim...

    Authors: Lisanne L. de Boer, Torre M. Bydlon, Frederieke van Duijnhoven, Marie-Jeanne T. F. D. Vranken Peeters, Claudette E. Loo, Gonneke A. O. Winter-Warnars, Joyce Sanders, Henricus J. C. M. Sterenborg, Benno H. W. Hendriks and Theo J. M. Ruers

    Citation: Journal of Translational Medicine 2018 16:367

    Content type: Research

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  26. The human epidermal growth factor receptor 2 (HER2) involved proliferation, angiogenesis, and reduced apoptosis in gastric cancer (GC), which is a common target for tumor therapy. HER2 is usually overexpressed...

    Authors: Siao-Syun Guan, Cheng-Tien Wu, Chen-Yuan Chiu, Tsai-Yueh Luo, Jeng-Yih Wu, Tse-Zung Liao and Shing-Hwa Liu

    Citation: Journal of Translational Medicine 2018 16:168

    Content type: Research

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  27. Surgical resection remains the mainstay of curative treatment for intrahepatic cholangiocarcinoma (ICC). Prognosis after surgery is unsatisfactory despite improvements in treatment and post-operative clinical ...

    Authors: Yoshinobu Ikeno, Satoru Seo, Keiko Iwaisako, Tomoaki Yoh, Yuji Nakamoto, Hiroaki Fuji, Kojiro Taura, Hideaki Okajima, Toshimi Kaido, Shimon Sakaguchi and Shinji Uemoto

    Citation: Journal of Translational Medicine 2018 16:95

    Content type: Research

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  28. Magnetic resonance is a major preclinical and clinical imaging modality ideally suited for longitudinal studies, e.g. in pharmacological developments. The lack of a proven platform that maintains an identical ...

    Authors: Jörg Felder, A. Avdo Celik, Chang-Hoon Choi, Stefan Schwan and N. Jon Shah

    Citation: Journal of Translational Medicine 2017 15:264

    Content type: Methodology

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  29. Systemic amyloidoses comprise diseases characterized by the deposition of proteinaceous material known as amyloid. Currently, without performing multiple biopsies, there is no way to ascertain the extent of am...

    Authors: Emily B. Martin, Angela Williams, Tina Richey, Craig Wooliver, Alan Stuckey, James S. Foster, Stephen J. Kennel and Jonathan S. Wall

    Citation: Journal of Translational Medicine 2017 15:247

    Content type: Research

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  30. Dynamic-contrast-enhanced (DCE) MRI data acquired using gradient echo based sequences is affected by errors in flip angle (FA) due to transmit B1 inhomogeneity (B1inh). The purpose of the study was to evaluate th...

    Authors: Anirban Sengupta, Rakesh Kumar Gupta and Anup Singh

    Citation: Journal of Translational Medicine 2017 15:242

    Content type: Research

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  31. Asthma is a multifactorial disease for which a variety of mouse models have been developed. A major drawback of these models is represented by the transient nature of the airway pathology peaking 24–72 h after...

    Authors: Fabio Stellari, Angelo Sala, Francesca Ruscitti, Chiara Carnini, Prisco Mirandola, Marco Vitale, Maurizio Civelli and Gino Villetti

    Citation: Journal of Translational Medicine 2015 13:336

    Content type: Research

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  32. Acute-on-chronic liver failure (ACLF) is a form of liver disease with high short-term mortality. ACLF offers considerable potential to affect the cortical areas by significant tissue injury due to loss of neur...

    Authors: Santosh K. Yadav, Rakesh K. Gupta, Vivek A. Saraswat, Murali Rangan, Michael A. Thomas, Sergio Rutella, Silvio Danese, Ena Wang, Francesco M. Marincola and Mohammad Haris

    Citation: Journal of Translational Medicine 2015 13:322

    Content type: Research

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  33. A real-time objective evaluation for the extent of liver steatosis during liver transplantation is currently not available. Diffuse reflectance spectroscopy (DRS) rapidly and accurately assesses the extent of...

    Authors: Andrie C. Westerkamp, Vishnu V. Pully, Golnar Karimian, Fernanda Bomfati, Zwanida J. Veldhuis, Janneke Wiersema-Buist, Benno H. W. Hendriks, Ton Lisman and Robert J. Porte

    Citation: Journal of Translational Medicine 2015 13:309

    Content type: Research

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  34. Liver fibrosis is a public health problem worldwide. There is a need of noninvasive imaging based methods for better diagnosis of this disease. In the current study, we aim to evaluate the potential of T1ρ MRI...

    Authors: Anup Singh, Damodar Reddy, Mohammad Haris, Kejia Cai, K. Rajender Reddy, Hari Hariharan and Ravinder Reddy

    Citation: Journal of Translational Medicine 2015 13:292

    Content type: Research

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  35. To acquire the most meaningful understanding of human arthritis, it is essential to select the disease model and methodology translatable to human conditions. The primary objective of this study was to evaluat...

    Authors: Cedo M. Bagi, David E. Zakur, Edwin Berryman, Catharine J. Andresen and Dean Wilkie

    Citation: Journal of Translational Medicine 2015 13:276

    Content type: Methodology

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  36. Chronic inflammation of the airways is a central component in lung diseases and is frequently associated with bacterial infections. Monitoring the pro-inflammatory capability of bacterial virulence factors in ...

    Authors: Fabio Stellari, Gabriella Bergamini, Angela Sandri, Gaetano Donofrio, Claudio Sorio, Francesca Ruscitti, Gino Villetti, Barouk M Assael, Paola Melotti and Maria M Lleo

    Citation: Journal of Translational Medicine 2015 13:251

    Content type: Research

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