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Translational Signaling and System Biology

Section edited by Marcello Maggiolini

© © selvanegra / Getty Images / iStock

The Translational Signaling and System Biology section aims to uncover pivotal transduction signaling involved in pathophysiological processes toward a translational impact on the discovery of novel targets and therapeutics. 

The section welcomes research and review articles providing new mechanistic insights on a broad range of fields such as cancer, cardiovascular biology, neuroscience, metabolism, inflammation, immunology, microbiology, drug action also through new formulations and delivery methods, novel cellular and animal models, computational and systems biology, innovative laboratory concepts fostering translational research from the bench to the bedside.

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  1. In the fight against GBM, drug repurposing emerges as a viable and time-saving approach to explore new treatment options. Chlorpromazine, an old antipsychotic medication, has recently arisen as a promising can...

    Authors: Paola Matarrese, Michele Signore, Barbara Ascione, Giulia Fanelli, Marco G. Paggi and Claudia Abbruzzese
    Citation: Journal of Translational Medicine 2024 22:667
  2. Metastatic breast cancer (mBC) poses a significant threat to women's health and is a major cause of malignant neoplasms in women. Human epidermal growth factor receptor (HER)3, an integral member of the ErbB/H...

    Authors: Meiying Zhu, Minghui Yu, Yuan Meng, Jie Yang, Xuerui Wang, Longhui LI, Yangyueying Liang and Fanming Kong
    Citation: Journal of Translational Medicine 2024 22:665
  3. From the first steps of prostate cancer (PCa) initiation, tumours are in contact with the most-proximal adipose tissue called periprostatic adipose tissue (PPAT). Extracellular vesicles are important carriers ...

    Authors: Silvia Sánchez-Martin, Antonio Altuna-Coy, Verónica Arreaza-Gil, Xana Bernal-Escoté, Joan Francesc Garcia Fontgivell, Helena Ascaso-Til, José Segarra-Tomás, Xavier Ruiz-Plazas and Matilde R. Chacón
    Citation: Journal of Translational Medicine 2024 22:661
  4. Non-small cell lung cancer (NSCLC) patients with EGFR mutations exhibit an unfavorable response to immune checkpoint inhibitor (ICI) monotherapy, and their tumor microenvironment (TME) is usually immunosuppressed...

    Authors: Huayan Huang, Xiaokuan Zhu, Yongfeng Yu, Ziming Li, Yi Yang, Liliang Xia and Shun Lu
    Citation: Journal of Translational Medicine 2024 22:653
  5. Breast cancer is one of the most common malignant tumors in women. Cell division cycle associated 5 (CDCA5), a master regulator of sister chromatid cohesion, was reported to be upregulated in several types of ...

    Authors: Yiquan Xiong, Lan Shi, Lei Li, Wen Yang, Huiqiong Zhang, Xiangwang Zhao and Na Shen
    Citation: Journal of Translational Medicine 2024 22:639
  6. Wnt/β-catenin signalling impairment accounts for 85% of colorectal cancers (CRCs), including sporadic and familial adenomatous polyposis (FAP) settings. An altered PI3K/mTOR pathway and gut microbiota also con...

    Authors: Floriana Jessica Di Paola, Chiara Alquati, Gabriele Conti, Giulia Calafato, Silvia Turroni, Federica D’Amico, Claudio Ceccarelli, Francesco Buttitta, Alice Bernardi, Dajana Cuicchi, Gilberto Poggioli, Daniela Turchetti, Simona Ferrari, Renato Cannizzaro, Stefano Realdon, Patrizia Brigidi…
    Citation: Journal of Translational Medicine 2024 22:631
  7. Existing studies have found that circular RNAs (circRNAs) act as sponges for micro RNAs (miRNAs) to control downstream genes. However, the specific functionalities and mechanisms of circRNAs in human clear cel...

    Authors: Gao-sheng Yao, Liang-min Fu, Jun-shang Dai, Jin-wei Chen, Ke-zhi Liu, Hui Liang, Zhu Wang, Qiong Deng, Jie-yan Wang, Mei-yu Jin, Wei Chen, Yong Fang, Jun-hang Luo, Jia-zheng Cao and Jin-huan Wei
    Citation: Journal of Translational Medicine 2024 22:596
  8. Lung cancer is the primary cause of cancer-related death worldwide, and its global incidence and mortality rates remain high. The differential expression of circular RNAs (circRNAs) can affect the development ...

    Authors: Haotian Xu, Yue Zheng, Jiaxi Wu, Ruirui Zhang, Qingyun Zhao, Sixian Chen, Wenyi Peng, Dunyu Cai, Yihong Gao, Xingcai Chen, Deqing Li, Shengyi yuan, Gang Li and Aruo Nan
    Citation: Journal of Translational Medicine 2024 22:590
  9. The prevalence of papillary thyroid cancer (PTC) has been rising in recent years. Despite its relatively low mortality, PTC frequently metastasizes to lymph nodes and often recurs, posing significant health an...

    Authors: Jing-jing Li, Zi-xuan Ru, Xu Yang, Jing-xue Sun, Yan-mei-zhi Wu, Xiao-yao Yang, Bo-yu Hou, Bing Xue, Chao Ding and Hong Qiao
    Citation: Journal of Translational Medicine 2024 22:586
  10. KIAA1429, a regulatory subunit of the N6-methyladenosine (m6A) methyltransferase complex, has been implicated in the progression of various cancers. However, the role of KIAA1429 in gastric cancer (GC) and its un...

    Authors: Mengting Ren, Hanghai Pan, Xinxin Zhou, Mosang Yu and Feng Ji
    Citation: Journal of Translational Medicine 2024 22:584
  11. The importance of the immune microenvironment in poorly cohesive carcinoma (PCC) has been highlighted due to its limited response rate to conventional therapy and emerging treatment resistance. A combination o...

    Authors: Yuan-jie Liu, Jie-pin Li, Mei Han, Jing-xiao Li, Qian-wen Ye, Si-tian Lin, Jin-yong Zhou, Shen-lin Liu and Xi Zou
    Citation: Journal of Translational Medicine 2024 22:580
  12. Cancer remains a leading cause of mortality and poses a substantial threat to public health. Studies have revealed that Long noncoding RNA DANCR is a cytoplasmic lncRNA whose aberrant expression plays a pivota...

    Authors: Rong Yuan, Zhao-jun Xu, Sheng-kang Zhang, Xian-ya Cao, Ai-guo Dai and Lan Song
    Citation: Journal of Translational Medicine 2024 22:569
  13. Enhancers are important gene regulatory elements that promote the expression of critical genes in development and disease. Aberrant enhancer can modulate cancer risk and activate oncogenes that lead to the occ...

    Authors: Junyou Zhang, Qilin Wang, Sihan Qi, Yingying Duan, Zhaoshuo Liu, Jiaxin Liu, Ziyi Zhang and Chunyan Li
    Citation: Journal of Translational Medicine 2024 22:547
  14. Apalutamide, a novel endocrine therapy agent, has been shown to significantly improve the prognosis of patients with metastatic hormone-sensitive prostate cancer (mHSPC). However, resistance to apalutamide has...

    Authors: Zihao Qi, Xiaojie Bai, Linjie Wu, Peng Zhang, Zhongqiang Guo and Ying Yu
    Citation: Journal of Translational Medicine 2024 22:538
  15. Clear cell renal cell carcinoma (ccRCC) is a common disease in the urinary system, with a high incidence and poor prognosis in advanced stages. Although γ-interferon-inducible protein 16 (IFI16) has been repor...

    Authors: Ke Lu, Yan Zhao, Yu Li, Zhenyu Fu, Yongchang Chen, Ying Kong and Gang Li
    Citation: Journal of Translational Medicine 2024 22:533
  16. Circular RNAs (circRNAs), which are a new type of single-stranded circular RNA, have significant involvement in progression of many diseases, including tumors. Currently, multiple circRNAs have been identified...

    Authors: Jiahao Gong, Guoyong Han, Zhiqiang Chen, Yinqi Zhang, Bin Xu, Chao Xu, Wen Gao and Jindao Wu
    Citation: Journal of Translational Medicine 2024 22:517
  17. Lung adenocarcinoma (LUAD) is a highly lethal form of lung cancer. Despite advancements in treatments, managing LUAD is still challenging due to its aggressive behavior. Recent studies indicate that various mo...

    Authors: Ming Liu, Shaoxian Wu, Haoyu Wu, You Zhou, Xinyu Zhang, Dawei Zhu and Jingting Jiang
    Citation: Journal of Translational Medicine 2024 22:510
  18. Gastric cancer (GC) ranks fifth in global cancer incidence and third in mortality rate among all cancer types. Circular RNAs (circRNAs) have been extensively demonstrated to regulate multiple malignant biologi...

    Authors: Yu-Ying Liu, Yu-Ying Zhang, Ling-Yu Ran, Bo Huang, Jun-Wu Ren, Qiang Ma, Xiao-Juan Pan, Fei-Fei Yang, Ce Liang, Xiao-Lin Wang, Shi-Min Wang, Ai Ran, Hao Ning, Yan Jiang, Chang-Hong Qin and Bin Xiao
    Citation: Journal of Translational Medicine 2024 22:507
  19. N6-methyladenosine (m6A) stands as the most prevalent modified form of RNA in eukaryotes, pivotal in various biological processes such as regulating RNA stability, translation, and transcription. All members w...

    Authors: Xudong Wu, Hui Chen, Kai Li, Hong Zhang, Kai Li and Haoyu Tan
    Citation: Journal of Translational Medicine 2024 22:490
  20. Tripartite motif-containing 26 (TRIM26), a member of the TRIM protein family, exerts dual function in several types of cancer. Nevertheless, the precise role of TRIM26 in clear cell renal cell carcinoma (ccRCC...

    Authors: Di Zheng, Jinzhuo Ning, Hao Deng, Yuan Ruan and Fan Cheng
    Citation: Journal of Translational Medicine 2024 22:481
  21. The initiation of fibroblast growth factor 1 (FGF1) expression coincident with the decrease of FGF2 expression is a well-documented event in prostate cancer (PCa) progression. Lactate dehydrogenase A (LDHA) an...

    Authors: Yongkang Ye, Fukan Yang, Zhanhao Gu, Wenxuan Li, Yinjiao Yuan, Shaoqian Liu, Le Zhou, Bo Han, Ruinian Zheng and Zhengguo Cao
    Citation: Journal of Translational Medicine 2024 22:474
  22. Colorectal cancer (CRC) remains a major global health challenge, with high incidence and mortality rates. The role of long noncoding RNAs (lncRNAs) in cancer progression has received considerable attention. Th...

    Authors: Mingkun Wang, Xuben Niu, Maihuan Wang, Peng Zheng, Xiaoya Liu, Zhen Cao and Chaojun Zhang
    Citation: Journal of Translational Medicine 2024 22:469
  23. Gastric intestinal metaplasia (GIM) is an essential precancerous lesion. Although the reversal of GIM is challenging, it potentially brings a state-to-art strategy for gastric cancer therapeutics (GC). The lac...

    Authors: Simeng Liu, Huijuan Wen, Fazhan Li, Xia Xue, Xiangdong Sun, Fuhao Li, Ruoyu Hu, Huayuan Xi, Francesco Boccellato, Thomas F Meyer, Yang Mi and Pengyuan Zheng
    Citation: Journal of Translational Medicine 2024 22:468
  24. Estetrol (E4) is a natural estrogen produced by the fetal liver during pregnancy. Due to its favorable safety profile, E4 was recently approved as estrogenic component of a new combined oral contraceptive. E4 ...

    Authors: Francesca Cirillo, Asia Spinelli, Marianna Talia, Domenica Scordamaglia, Maria Francesca Santolla, Fedora Grande, Bruno Rizzuti, Marcello Maggiolini, Céline Gérard and Rosamaria Lappano
    Citation: Journal of Translational Medicine 2024 22:450
  25. The mesenchymal subtype of colorectal cancer (CRC), associated with poor prognosis, is characterized by abundant expression of the cellular prion protein PrPC, which represents a candidate therapeutic target. How...

    Authors: Sophie Mouillet-Richard, Angélique Gougelet, Bruno Passet, Camille Brochard, Delphine Le Corre, Caterina Luana Pitasi, Camille Joubel, Marine Sroussi, Claire Gallois, Julien Lavergne, Johan Castille, Marthe Vilotte, Nathalie Daniel-Carlier, Camilla Pilati, Aurélien de Reyniès, Fatima Djouadi…
    Citation: Journal of Translational Medicine 2024 22:337
  26. Benign prostatic hyperplasia (BPH) is common in elder men. The current study aims to identify differentially expressed genes (DEGs) in hyperplastic prostate and to explore the role of Nik related kinase (NRK) ...

    Authors: Weixiang He, Zelin Tian, Bingchen Dong, Yitong Cao, Wei Hu, Peng Wu, Lei Yu, Xinhua Zhang and Shanshan Guo
    Citation: Journal of Translational Medicine 2024 22:255
  27. Circular RNAs (circRNAs) have been proved to play crucial roles in the development of various cancers. However, the molecular mechanism of circGLIS3 involved in gastric cancer (GC) tumorigenesis has not been e...

    Authors: Yongxin Zhang, Xiaofeng Wang, Wenwei Liu, Tianxiang Lei, Tang Qiao, Wei Feng and Wu Song
    Citation: Journal of Translational Medicine 2024 22:251
  28. Lung adenocarcinoma (LUAD) is the most common pathological type of lung cancer, but the early diagnosis rate is low. The RNA-binding ubiquitin ligase MEX3C promotes tumorigenesis in several cancers but its mec...

    Authors: Zelai He, Huijun Zhang, Haibo Xiao, Xiangyu Zhang, Hongbo Xu, Ruifen Sun and Siwen Li
    Citation: Journal of Translational Medicine 2024 22:216
  29. Lactylation, a novel contributor to post-translational protein modifications, exhibits dysregulation across various tumors. Nevertheless, its intricate involvement in colorectal carcinoma, particularly for non...

    Authors: Huixia Huang, Keji Chen, Yifei Zhu, Zijuan Hu, Yaxian Wang, Jiayu Chen, Yuxue Li, Dawei Li and Ping Wei
    Citation: Journal of Translational Medicine 2024 22:211
  30. Mitochondrial alterations, often dependent on unbalanced mitochondrial dynamics, feature in the pathobiology of human cancers, including multiple myeloma (MM). Flavanones are natural flavonoids endowed with mi...

    Authors: Roberta Torcasio, Maria Eugenia Gallo Cantafio, Claudia Veneziano, Carmela De Marco, Ludovica Ganino, Ilenia Valentino, Maria Antonietta Occhiuzzi, Ida Daniela Perrotta, Teresa Mancuso, Filomena Conforti, Bruno Rizzuti, Enrica Antonia Martino, Massimo Gentile, Antonino Neri, Giuseppe Viglietto, Fedora Grande…
    Citation: Journal of Translational Medicine 2024 22:208
  31. Castration-resistant prostate cancer (CRPC) is refractory to hormone treatment, and the underlying mechanism has not been fully elucidated. This study aimed to clarify the role and mechanism of Human antigen R...

    Authors: Hang You, Guojing Song, Zhizhen Xu, Saipeng Chen, Wenhao Shen, Heting Liu, Bingqian Deng, Jun Li and Gang Huang
    Citation: Journal of Translational Medicine 2024 22:178
  32. Several evidence demonstrated that glucagon-like peptide 1 receptor agonists (GLP1-RAs) reduce the risk of dementia in type 2 diabetes patients by improving memory, learning, and overcoming cognitive impairmen...

    Authors: Rosaria Anna Fontanella, Puja Ghosh, Ada Pesapane, Fatemeh Taktaz, Armando Puocci, Martina Franzese, Maria Federica Feliciano, Giovanni Tortorella, Lucia Scisciola, Eduardo Sommella, Concetta Ambrosino, Giuseppe Paolisso and Michelangela Barbieri
    Citation: Journal of Translational Medicine 2024 22:114
  33. Ovarian cancer poses a serious threat to women's health. Due to the difficulty of early detection, most patients are diagnosed with advanced-stage disease or peritoneal metastasis. We found that LncRNA MEG3 is...

    Authors: Yan Li, Shenghan Lou, Jian Zhang, Shilu Zhao and Ge Lou
    Citation: Journal of Translational Medicine 2024 22:113
  34. Non-alcoholic fatty liver disease (NAFLD) is a liver disorder characterized by the ac-cumulation of fat in hepatocytes without alcohol consumption. Mitochondrial dysfunction and endoplasmic reticulum (ER) stre...

    Authors: Lucia Longhitano, Alfio Distefano, Nicolò Musso, Paolo Bonacci, Laura Orlando, Sebastiano Giallongo, Daniele Tibullo, Simona Denaro, Giuseppe Lazzarino, Jessica Ferrigno, Anna Nicolosi, Amer M. Alanazi, Federico Salomone, Emanuela Tropea, Ignazio Alberto Barbagallo, Vincenzo Bramanti…
    Citation: Journal of Translational Medicine 2024 22:82
  35. Lung cancer is the most prevalent cancer worldwide, with non-small cell lung cancer (NSCLC) accounting for 85% of all cases. Circular RNAs(circRNA) play crucial roles in regulating the progression of lung canc...

    Authors: Jinbin Chen, Boqi Rao, Zeqin Huang, Chen Xie, Yonghui Yu, Binyao Yang, Di Wu, Dedong Wang, Fuman Qiu, Yifeng Zhou, Yibin Deng and Jiachun Lu
    Citation: Journal of Translational Medicine 2024 22:47
  36. Mucosal Melanomas (MM) are highly aggressive neoplasms arising from mucosal melanocytes. Current treatments offer a limited survival benefit for patients with advanced MM; moreover, the lack of pre-clinical ce...

    Authors: Matilde Monti, Luisa Benerini Gatta, Mattia Bugatti, Irene Pezzali, Sara Picinoli, Marcello Manfredi, Antonio Lavazza, Virginia Vita Vanella, Veronica De Giorgis, Lucia Zanatta, Francesco Missale, Silvia Lonardi, Benedetta Zanetti, Giovanni Bozzoni, Moris Cadei, Andrea Abate…
    Citation: Journal of Translational Medicine 2024 22:35
  37. Pancreatic ductal adenocarcinoma (PDAC) is characterized by rapid progression and poor prognosis. Understanding the genetic mechanisms that affect cancer properties and reprogram tumor immune microenvironment ...

    Authors: Wenbo Yang, Hongze Chen, Guanqun Li, Tao Zhang, Yuhang Sui, Liwei Liu, Jisheng Hu, Gang Wang, Hua Chen, Yongwei Wang, Xina Li, Hongtao Tan, Rui Kong, Bei Sun and Le Li
    Citation: Journal of Translational Medicine 2023 21:903
  38. Advanced prostate cancer (PCa) will develop into castration-resistant prostate cancer (CRPC) and lead to poor prognosis. As the primary subtype of CRPC, CRPC-AR accounts for the major induction of PCa heteroge...

    Authors: Maozhang Li, Guangwei Bai, Yi Cen, Qitong Xie, Jiahong Chen, Jia Chen, Qingbiao Chen, Weide Zhong and Xiaobo Zhou
    Citation: Journal of Translational Medicine 2023 21:884
  39. Breast cancer (BC) is a prevalent malignancy with complex etiology and varied clinical behavior. Long non-coding RNAs (lncRNAs) have emerged as key regulators in cancer progression, including BC. Among these, ...

    Authors: Yuqin Ding, Yuting Huang, Fanrong Zhang, Lijie Gong, Chenlu Liang, Kaijing Ding, Xiangming He, Xiaowen Ding and Yiding Chen
    Citation: Journal of Translational Medicine 2023 21:854
  40. Prostate cancer (PCa) is currently acknowledged as the second most widespread cancer among men worldwide. Yet, the lack of dependable diagnostic biomarkers and therapeutic targets has presented considerable hu...

    Authors: Lingxiang Lu, Fei Wang, Jianchun Chen, Chunchun Zhao, Shuai Guo, Da Dong, Minjun Jiang and Yuhua Huang
    Citation: Journal of Translational Medicine 2023 21:850
  41. Fibroblast growth factor receptor 1 (FGFR1) is a core component of the FGFs/FGFR pathway that activates multiple signalling pathways, including ERK1/2, PI3K/AKT, PLCγ, and NF-κB. Aberrant expression of FGFR1 due ...

    Authors: Ruyue Wang, Jinjing Zhong, Xiuyi Pan, Zhengzheng Su, Yunyi Xu, Mengni Zhang, Xueqin Chen, Ni Chen, Ting Yu and Qiao Zhou
    Citation: Journal of Translational Medicine 2023 21:840
  42. Protein palmitoylation, which is catalyzed by palmitoyl-transferase and de-palmitoyl-transferase, plays a crucial role in various biological processes. However, the landscape and dynamics of protein palmitoyla...

    Authors: Yue Kong, Yugeng Liu, Xianzhe Li, Menglan Rao, Dawei Li, Xiaolan Ruan, Shanglin Li, Zhenyou Jiang and Qiang Zhang
    Citation: Journal of Translational Medicine 2023 21:826
  43. Sirtuin 7 (SIRT7) is an oncogene that promotes tumor progression in various malignancies, however, its role and regulatory mechanism in cervical squamous cell carcinoma (CSCC) is unknown. Herein, we attempted ...

    Authors: Juanpeng Yu, Shuai Yuan, Jinglin Song and Shengsheng Yu
    Citation: Journal of Translational Medicine 2023 21:807
  44. Follicular thyroid cancer (FTC) is a prevalent form of differentiated thyroid cancer, whereas anaplastic thyroid cancer (ATC) represents a rare, fast-growing, undifferentiated, and highly aggressive tumor, pos...

    Authors: Simona D’Aprile, Simona Denaro, Anna Maria Pavone, Sebastiano Giallongo, Cesarina Giallongo, Alfio Distefano, Lucia Salvatorelli, Filippo Torrisi, Raffaella Giuffrida, Stefano Forte, Daniele Tibullo, Giovanni Li Volti, Gaetano Magro, Nunzio Vicario and Rosalba Parenti
    Citation: Journal of Translational Medicine 2023 21:780
  45. The phosphoinositide 3-kinase (PI3K)/AKT signaling pathway plays a crucial role in the pathogenesis of cancer. The dysregulation of this pathway has been linked to the development and initiation of various typ...

    Authors: Jie Liu, Xinyu Gu, Zhenjie Guan, Di Huang, Huiwu Xing and Lian Zheng
    Citation: Journal of Translational Medicine 2023 21:774
  46. Colorectal cancer (CRC) is the third most deadly and fourth most diagnosed cancer worldwide. Despite the progress in early diagnosis and advanced therapeutic options, CRC shows a poor prognosis with a 5 year s...

    Authors: Marzia Di Donato, Erika Di Zazzo, Annamaria Salvati, Carmela Sorrentino, Giorgio Giurato, Donatella Fiore, Maria Chiara Proto, Monica Rienzo, Amelia Casamassimi, Patrizia Gazzerro, Maurizio Bifulco, Gabriella Castoria, Alessandro Weisz, Giovanni Nassa and Ciro Abbondanza
    Citation: Journal of Translational Medicine 2023 21:736
  47. Androgen receptor (AR) activation and repression dual-functionality only became known recently and still remains intriguing in prostate cancer (PCa). MYC is a prominent oncogene that functionally entangles wit...

    Authors: Ju Guo, Zhao Wei, Tianwei Jia, Liyang Wang, Nuosu Nama, Jiaqian Liang, Xinghua Liao, Xiaming Liu, Yanfei Gao, Xiaoqiang Liu, Keshan Wang, Bin Fu and Shaoyong Shawn Chen
    Citation: Journal of Translational Medicine 2023 21:716
  48. Ubiquitination is one of the most significant post-translational modifications that regulate almost all physiological processes like cell proliferation, autophagy, apoptosis, and cell cycle progression. Contra...

    Authors: Kaiyi Niu, Yanlong Shi, Qingpeng Lv, Yizhu Wang, Jiping Chen, Wenning Zhang, Kung Feng and Yewei Zhang
    Citation: Journal of Translational Medicine 2023 21:665