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Translational Signaling and System Biology

Section edited by Marcello Maggiolini

© © selvanegra / Getty Images / iStock

The Translational Signaling and System Biology section aims to uncover pivotal transduction signaling involved in pathophysiological processes toward a translational impact on the discovery of novel targets and therapeutics. 

The section welcomes research and review articles providing new mechanistic insights on a broad range of fields such as cancer, cardiovascular biology, neuroscience, metabolism, inflammation, immunology, microbiology, drug action also through new formulations and delivery methods, novel cellular and animal models, computational and systems biology, innovative laboratory concepts fostering translational research from the bench to the bedside.

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  1. Hyperactive RNA Polymerase I (Pol I) transcription is canonical in cancer, associated with malignant proliferation, poor prognosis, epithelial-mesenchymal transition, and chemotherapy resistance. Despite its s...

    Authors: Shashanka Shekhar Sarkar, Mansi Sharma, Sheetanshu Saproo and Srivatsava Naidu
    Citation: Journal of Translational Medicine 2024 22:904
  2. Muscle invasive bladder cancer (MIBC) is a life-threatening malignant tumor characterized by high metastasis rates, poor prognosis, and limited treatment options. Immune checkpoint inhibitors (ICIs) targeting ...

    Authors: Yaobang Wang, Wuyue Song, Chao Feng, Shulin Wu, Zezu Qin, Tao Liu, Yu Ye, Rong Huang, Yuanliang Xie, Zhong Tang, Qiuyan Wang and Tianyu Li
    Citation: Journal of Translational Medicine 2024 22:900
  3. Ductal carcinoma in situ (DCIS) of the breast is an early stage of breast cancer, and preventing its progression to invasive ductal carcinoma (IDC) is crucial for the early detection and treatment of breast ca...

    Authors: Yidi Sun, Zhuoyu Pan, Ziyi Wang, Haofei Wang, Leyi Wei, Feifei Cui, Quan Zou and Zilong Zhang
    Citation: Journal of Translational Medicine 2024 22:894
  4. Pituitary adenomas (PAs) are the second most common intracranial tumor. While current diagnostic practices rely primarily on histological testing, they often fail to capture the molecular complexities of pitui...

    Authors: Jiayi Peng, Linhao Yuan, Peng Kang, Shucheng Jin, Shunchang Ma, Wenjianlong Zhou, Guijun Jia, Chuanbao Zhang and Wang Jia
    Citation: Journal of Translational Medicine 2024 22:892
  5. Cancer onset and progression are driven by genetic and epigenetic alterations leading to oncogene activation and the silencing of tumor suppressor genes. Among epigenetic mechanisms, DNA methylation (methDNA) ...

    Authors: Alessandro Lavoro, Luca Falzone, Giuseppe Gattuso, Giuseppe N. Conti, Rosario Caltabiano, Gabriele Madonna, Mariaelena Capone, James A. McCubrey, Paolo A. Ascierto, Massimo Libra and Saverio Candido
    Citation: Journal of Translational Medicine 2024 22:887
  6. Tobacco smoking is the leading cause of preventable death and disease worldwide, with over 8 million annual deaths attributed to cigarette smoking. This study investigates the impact of cigarette smoke and hea...

    Authors: Alfio Distefano, Laura Orlando, Konstantinos Partsinevelos, Lucia Longhitano, Rosalia Emma, Massimo Caruso, Nunzio Vicario, Simona Denaro, Ang Sun, Antonio Giordano, Barbara Tomasello, Amer M. Alanazi, Giovanni Li Volti and Angela Maria Amorini
    Citation: Journal of Translational Medicine 2024 22:876
  7. To examine the putative functions and mechanisms of lysine crotonylation (Kcr) during the development and progression of papillary thyroid cancer (PTC).

    Authors: Zhaokun Li, Jingting Li, Fang Li, Liang Han, Chengqiu Sui, Le Zhou, Daqi Zhang, Yantao Fu, Rui Du, Jiedong Kou, Gianlorenzo Dionigi, Hui Sun and Nan Liang
    Citation: Journal of Translational Medicine 2024 22:874
  8. LINC01089 is a prime example of a long non-coding RNA that plays a pivotal role in the progression of human cancers. The gene encoding this lncRNA is located on 12q24.31. LINC01089 has been demonstrated to exe...

    Authors: Qiang Yi, Gangfeng Zhu, Xinting Ouyang, Weijian Zhu, Kui Zhong, Zheng Chen and Jinghua Zhong
    Citation: Journal of Translational Medicine 2024 22:858
  9. Owing to patient-derived tumor tissues and cells, significant advances have been made in personalized cancer treatment and precision medicine, with cancer stem cell-derived three-dimensional tumor organoids se...

    Authors: Ling-Feng Zhou, Hui-Yan Liao, Yang Han and Yang Zhao
    Citation: Journal of Translational Medicine 2024 22:856
  10. Authors: Marianna Talia, Eugenio Cesario, Francesca Cirillo, Domenica Scordamaglia, Marika Di Dio, Azzurra Zicarelli, Adelina Assunta Mondino, Maria Antonietta Occhiuzzi, Ernestina Marianna De Francesco, Antonino Belfiore, Anna Maria Miglietta, Michele Di Dio, Carlo Capalbo, Marcello Maggiolini and Rosamaria Lappano
    Citation: Journal of Translational Medicine 2024 22:846

    The original article was published in Journal of Translational Medicine 2024 22:699

  11. Family with sequence similarity 109, member B (FAM109B) is involved in endocytic transport and affects genetic variation in brain methylation. It is one of the important genes related to immune cell-associated...

    Authors: Zhe Zhang, Yao Xiao, Siyi Zhao, Jun Liu, Jie Zeng, Feng Xiao, Bin Liao, Xuesong Shan, Hong Zhu and Hua Guo
    Citation: Journal of Translational Medicine 2024 22:833
  12. Breast cancer (BC) is the most common malignant tumor in women worldwide, and further elucidation of the molecular mechanisms involved in BC pathogenesis is essential to improve the prognosis of BC patients. R...

    Authors: Fang Li, Xiaofei Wang, Jing Zhang, Jinyuan Zhang, Xintao Jing, Qiuyu Jiang, Jing Zhou, Li Cao, Hang Peng, Dongdong Tong and Chen Huang
    Citation: Journal of Translational Medicine 2024 22:823
  13. Neuroblastoma (NB) is a complex disease, and the current understanding of NB biology is limited. Deregulation in genomic imprinting is a common event in malignancy. Since imprinted genes play crucial roles in ...

    Authors: Medha Suman, Maja Löfgren, Susanne Fransson, Jewahri Idris Yousuf, Johanna Svensson, Anna Djos, Tommy Martinsson, Per Kogner, Teresia Kling and Helena Carén
    Citation: Journal of Translational Medicine 2024 22:808
  14. The metastasis of cancer cells is influenced by both their intrinsic characteristics and the tumor microenvironment (TME). However, the molecular mechanisms underlying pre-nodal metastases of breast cancer rem...

    Authors: Kaidong Liu, Huiming Han, Kai Xiong, Songmei Zhai, Xiuqi Yang, Xinmiao Yu, Bo Chen, Mingyue Liu, Qi Dong, Hongxue Meng and Yunyan Gu
    Citation: Journal of Translational Medicine 2024 22:804
  15. The development of acquired EGFR-TKI treatment resistance is still a major clinical challenge in the treatment of non-small cell lung cancer (NSCLC). This study aimed to investigate the role of HDAC1/FOXK1/miR...

    Authors: Jie Liu, Wei Wang, Kunkun Wang, Wenjing Liu, Yanqiu Zhao, Xiao Han, Lin Wang and Bing-Hua Jiang
    Citation: Journal of Translational Medicine 2024 22:793
  16. Marinesco-Sjögren syndrome (MSS) is an autosomal recessive neuromuscular disorder that arises in early childhood and is characterized by congenital cataracts, myopathy associated with muscle weakness, and dege...

    Authors: Laura Amodei, Anna Giulia Ruggieri, Francesca Potenza, Marianna Viele, Beatrice Dufrusine, Raffaella Franciotti, Laura Pietrangelo, Matteo Ardini, Liborio Stuppia, Luca Federici, Vincenzo De Laurenzi and Michele Sallese
    Citation: Journal of Translational Medicine 2024 22:787
  17. Multi-drug resistance of poly(morpho)nuclear giant cells (PGCs) determines their cytoprotective and generative potential in cancer ecosystems. However, mechanisms underlying the involvement of PGCs in glioblas...

    Authors: Maciej Pudełek, Damian Ryszawy, Katarzyna Piwowarczyk, Sławomir Lasota, Zbigniew Madeja, Sylwia Kędracka-Krok and Jarosław Czyż
    Citation: Journal of Translational Medicine 2024 22:757
  18. Circular RNAs (circRNAs) are a class of endogenous noncoding RNAs characterized by their lack of 5′ caps and 3′ poly(A) tails. These molecules have garnered substantial attention from the scientific community....

    Authors: Jun Zhang, Zai Luo, Yang Zheng, Mingyu Duan, Zhengjun Qiu and Chen Huang
    Citation: Journal of Translational Medicine 2024 22:752
  19. Targeting non-coding RNAs (ncRNAs), including microRNAs (miRNAs) and long non-coding RNAs (lncRNAs), has recently emerged as a promising strategy for treating malignancies and other diseases. In recent years, ...

    Authors: Katia Grillone, Giulio Caridà, Francesco Luciano, Alessia Cordua, Maria Teresa Di Martino, Pierosandro Tagliaferri and Pierfrancesco Tassone
    Citation: Journal of Translational Medicine 2024 22:731
  20. Drug resistance, including Adriamycin-based therapeutic resistance, remains a challenge in breast cancer (BC) treatment. Studies have revealed that macrophages could play a pivotal role in mediating the chemor...

    Authors: Dongping Mo, Xun Tang, Yuyan Ma, Dayu Chen, Weiguo Xu, Ning Jiang, Junyu Zheng and Feng Yan
    Citation: Journal of Translational Medicine 2024 22:706
  21. Authors: Guigeng Tan, Yuanyuan Shao and Zhiguo Zhu
    Citation: Journal of Translational Medicine 2024 22:699

    The original article was published in Journal of Translational Medicine 2024 22:597

    The Letter to the Editor to this article has been published in Journal of Translational Medicine 2024 22:846

  22. Circular RNAs (circRNAs) possess unique biological properties and distribution characteristics that enable a variety of biological functions. N6-methyladenosine (m6A), a prevalent epigenetic modification in or...

    Authors: Fenfang Liu, Wendong Gu and Yingjie Shao
    Citation: Journal of Translational Medicine 2024 22:694
  23. Increasing evidence suggests that long noncoding RNAs (lncRNAs) play important regulatory roles in biological processes and are dysregulated in numerous tumors. The lncRNA GRASLND functions as an oncogene in m...

    Authors: Aiwei Ma, Wenqi Shi, Liyun Chen, Zijian Huang, Yiwen Zhang, Zixuan Tang, Wenshi Jiang, Mengjing Xu, Jianda Zhou, Wancong Zhang and Shijie Tang
    Citation: Journal of Translational Medicine 2024 22:684
  24. Patients with lung adenocarcinoma (LUAD) have a low response rate to immune checkpoint blockade. It is highly important to explore the tumor immune escape mechanism of LUAD patients and expand the population o...

    Authors: Zhen Gao, Shang Liu, Han Xiao, Meng Li, Wan-gang Ren, Lin Xu and Zhong-min Peng
    Citation: Journal of Translational Medicine 2024 22:678
  25. Breast cancer manifests as a heterogeneous pathology marked by complex metabolic reprogramming essential to satisfy its energy demands. Oncogenic signals boost the metabolism, modifying fatty acid synthesis an...

    Authors: Chiara Papulino, Ugo Chianese, Ahmad Ali, Gregorio Favale, Concetta Tuccillo, Fortunato Ciardiello, Annabella Di Mauro, Chiara Mignogna, Gerardo Ferrara, Alfredo Budillon, Wouter Leonard Megchelenbrink, Nunzio Del Gaudio, Mariarosaria Conte, Fabrizio Merciai, Pietro Campiglia, Lucia Altucci…
    Citation: Journal of Translational Medicine 2024 22:676
  26. In the fight against GBM, drug repurposing emerges as a viable and time-saving approach to explore new treatment options. Chlorpromazine, an old antipsychotic medication, has recently arisen as a promising can...

    Authors: Paola Matarrese, Michele Signore, Barbara Ascione, Giulia Fanelli, Marco G. Paggi and Claudia Abbruzzese
    Citation: Journal of Translational Medicine 2024 22:667
  27. Metastatic breast cancer (mBC) poses a significant threat to women's health and is a major cause of malignant neoplasms in women. Human epidermal growth factor receptor (HER)3, an integral member of the ErbB/H...

    Authors: Meiying Zhu, Minghui Yu, Yuan Meng, Jie Yang, Xuerui Wang, Longhui LI, Yangyueying Liang and Fanming Kong
    Citation: Journal of Translational Medicine 2024 22:665
  28. From the first steps of prostate cancer (PCa) initiation, tumours are in contact with the most-proximal adipose tissue called periprostatic adipose tissue (PPAT). Extracellular vesicles are important carriers ...

    Authors: Silvia Sánchez-Martin, Antonio Altuna-Coy, Verónica Arreaza-Gil, Xana Bernal-Escoté, Joan Francesc Garcia Fontgivell, Helena Ascaso-Til, José Segarra-Tomás, Xavier Ruiz-Plazas and Matilde R. Chacón
    Citation: Journal of Translational Medicine 2024 22:661
  29. Non-small cell lung cancer (NSCLC) patients with EGFR mutations exhibit an unfavorable response to immune checkpoint inhibitor (ICI) monotherapy, and their tumor microenvironment (TME) is usually immunosuppressed...

    Authors: Huayan Huang, Xiaokuan Zhu, Yongfeng Yu, Ziming Li, Yi Yang, Liliang Xia and Shun Lu
    Citation: Journal of Translational Medicine 2024 22:653
  30. Breast cancer is one of the most common malignant tumors in women. Cell division cycle associated 5 (CDCA5), a master regulator of sister chromatid cohesion, was reported to be upregulated in several types of ...

    Authors: Yiquan Xiong, Lan Shi, Lei Li, Wen Yang, Huiqiong Zhang, Xiangwang Zhao and Na Shen
    Citation: Journal of Translational Medicine 2024 22:639
  31. Wnt/β-catenin signalling impairment accounts for 85% of colorectal cancers (CRCs), including sporadic and familial adenomatous polyposis (FAP) settings. An altered PI3K/mTOR pathway and gut microbiota also con...

    Authors: Floriana Jessica Di Paola, Chiara Alquati, Gabriele Conti, Giulia Calafato, Silvia Turroni, Federica D’Amico, Claudio Ceccarelli, Francesco Buttitta, Alice Bernardi, Dajana Cuicchi, Gilberto Poggioli, Daniela Turchetti, Simona Ferrari, Renato Cannizzaro, Stefano Realdon, Patrizia Brigidi…
    Citation: Journal of Translational Medicine 2024 22:631
  32. Existing studies have found that circular RNAs (circRNAs) act as sponges for micro RNAs (miRNAs) to control downstream genes. However, the specific functionalities and mechanisms of circRNAs in human clear cel...

    Authors: Gao-sheng Yao, Liang-min Fu, Jun-shang Dai, Jin-wei Chen, Ke-zhi Liu, Hui Liang, Zhu Wang, Qiong Deng, Jie-yan Wang, Mei-yu Jin, Wei Chen, Yong Fang, Jun-hang Luo, Jia-zheng Cao and Jin-huan Wei
    Citation: Journal of Translational Medicine 2024 22:596
  33. Lung cancer is the primary cause of cancer-related death worldwide, and its global incidence and mortality rates remain high. The differential expression of circular RNAs (circRNAs) can affect the development ...

    Authors: Haotian Xu, Yue Zheng, Jiaxi Wu, Ruirui Zhang, Qingyun Zhao, Sixian Chen, Wenyi Peng, Dunyu Cai, Yihong Gao, Xingcai Chen, Deqing Li, Shengyi yuan, Gang Li and Aruo Nan
    Citation: Journal of Translational Medicine 2024 22:590
  34. The prevalence of papillary thyroid cancer (PTC) has been rising in recent years. Despite its relatively low mortality, PTC frequently metastasizes to lymph nodes and often recurs, posing significant health an...

    Authors: Jing-jing Li, Zi-xuan Ru, Xu Yang, Jing-xue Sun, Yan-mei-zhi Wu, Xiao-yao Yang, Bo-yu Hou, Bing Xue, Chao Ding and Hong Qiao
    Citation: Journal of Translational Medicine 2024 22:586
  35. KIAA1429, a regulatory subunit of the N6-methyladenosine (m6A) methyltransferase complex, has been implicated in the progression of various cancers. However, the role of KIAA1429 in gastric cancer (GC) and its un...

    Authors: Mengting Ren, Hanghai Pan, Xinxin Zhou, Mosang Yu and Feng Ji
    Citation: Journal of Translational Medicine 2024 22:584
  36. The importance of the immune microenvironment in poorly cohesive carcinoma (PCC) has been highlighted due to its limited response rate to conventional therapy and emerging treatment resistance. A combination o...

    Authors: Yuan-jie Liu, Jie-pin Li, Mei Han, Jing-xiao Li, Qian-wen Ye, Si-tian Lin, Jin-yong Zhou, Shen-lin Liu and Xi Zou
    Citation: Journal of Translational Medicine 2024 22:580
  37. Cancer remains a leading cause of mortality and poses a substantial threat to public health. Studies have revealed that Long noncoding RNA DANCR is a cytoplasmic lncRNA whose aberrant expression plays a pivota...

    Authors: Rong Yuan, Zhao-jun Xu, Sheng-kang Zhang, Xian-ya Cao, Ai-guo Dai and Lan Song
    Citation: Journal of Translational Medicine 2024 22:569
  38. Enhancers are important gene regulatory elements that promote the expression of critical genes in development and disease. Aberrant enhancer can modulate cancer risk and activate oncogenes that lead to the occ...

    Authors: Junyou Zhang, Qilin Wang, Sihan Qi, Yingying Duan, Zhaoshuo Liu, Jiaxin Liu, Ziyi Zhang and Chunyan Li
    Citation: Journal of Translational Medicine 2024 22:547
  39. Apalutamide, a novel endocrine therapy agent, has been shown to significantly improve the prognosis of patients with metastatic hormone-sensitive prostate cancer (mHSPC). However, resistance to apalutamide has...

    Authors: Zihao Qi, Xiaojie Bai, Linjie Wu, Peng Zhang, Zhongqiang Guo and Ying Yu
    Citation: Journal of Translational Medicine 2024 22:538
  40. Clear cell renal cell carcinoma (ccRCC) is a common disease in the urinary system, with a high incidence and poor prognosis in advanced stages. Although γ-interferon-inducible protein 16 (IFI16) has been repor...

    Authors: Ke Lu, Yan Zhao, Yu Li, Zhenyu Fu, Yongchang Chen, Ying Kong and Gang Li
    Citation: Journal of Translational Medicine 2024 22:533
  41. Circular RNAs (circRNAs), which are a new type of single-stranded circular RNA, have significant involvement in progression of many diseases, including tumors. Currently, multiple circRNAs have been identified...

    Authors: Jiahao Gong, Guoyong Han, Zhiqiang Chen, Yinqi Zhang, Bin Xu, Chao Xu, Wen Gao and Jindao Wu
    Citation: Journal of Translational Medicine 2024 22:517
  42. Lung adenocarcinoma (LUAD) is a highly lethal form of lung cancer. Despite advancements in treatments, managing LUAD is still challenging due to its aggressive behavior. Recent studies indicate that various mo...

    Authors: Ming Liu, Shaoxian Wu, Haoyu Wu, You Zhou, Xinyu Zhang, Dawei Zhu and Jingting Jiang
    Citation: Journal of Translational Medicine 2024 22:510
  43. Gastric cancer (GC) ranks fifth in global cancer incidence and third in mortality rate among all cancer types. Circular RNAs (circRNAs) have been extensively demonstrated to regulate multiple malignant biologi...

    Authors: Yu-Ying Liu, Yu-Ying Zhang, Ling-Yu Ran, Bo Huang, Jun-Wu Ren, Qiang Ma, Xiao-Juan Pan, Fei-Fei Yang, Ce Liang, Xiao-Lin Wang, Shi-Min Wang, Ai Ran, Hao Ning, Yan Jiang, Chang-Hong Qin and Bin Xiao
    Citation: Journal of Translational Medicine 2024 22:507
  44. N6-methyladenosine (m6A) stands as the most prevalent modified form of RNA in eukaryotes, pivotal in various biological processes such as regulating RNA stability, translation, and transcription. All members w...

    Authors: Xudong Wu, Hui Chen, Kai Li, Hong Zhang, Kai Li and Haoyu Tan
    Citation: Journal of Translational Medicine 2024 22:490
  45. Tripartite motif-containing 26 (TRIM26), a member of the TRIM protein family, exerts dual function in several types of cancer. Nevertheless, the precise role of TRIM26 in clear cell renal cell carcinoma (ccRCC...

    Authors: Di Zheng, Jinzhuo Ning, Hao Deng, Yuan Ruan and Fan Cheng
    Citation: Journal of Translational Medicine 2024 22:481
  46. The initiation of fibroblast growth factor 1 (FGF1) expression coincident with the decrease of FGF2 expression is a well-documented event in prostate cancer (PCa) progression. Lactate dehydrogenase A (LDHA) an...

    Authors: Yongkang Ye, Fukan Yang, Zhanhao Gu, Wenxuan Li, Yinjiao Yuan, Shaoqian Liu, Le Zhou, Bo Han, Ruinian Zheng and Zhengguo Cao
    Citation: Journal of Translational Medicine 2024 22:474
  47. Colorectal cancer (CRC) remains a major global health challenge, with high incidence and mortality rates. The role of long noncoding RNAs (lncRNAs) in cancer progression has received considerable attention. Th...

    Authors: Mingkun Wang, Xuben Niu, Maihuan Wang, Peng Zheng, Xiaoya Liu, Zhen Cao and Chaojun Zhang
    Citation: Journal of Translational Medicine 2024 22:469
  48. Gastric intestinal metaplasia (GIM) is an essential precancerous lesion. Although the reversal of GIM is challenging, it potentially brings a state-to-art strategy for gastric cancer therapeutics (GC). The lac...

    Authors: Simeng Liu, Huijuan Wen, Fazhan Li, Xia Xue, Xiangdong Sun, Fuhao Li, Ruoyu Hu, Huayuan Xi, Francesco Boccellato, Thomas F Meyer, Yang Mi and Pengyuan Zheng
    Citation: Journal of Translational Medicine 2024 22:468
  49. Estetrol (E4) is a natural estrogen produced by the fetal liver during pregnancy. Due to its favorable safety profile, E4 was recently approved as estrogenic component of a new combined oral contraceptive. E4 ...

    Authors: Francesca Cirillo, Asia Spinelli, Marianna Talia, Domenica Scordamaglia, Maria Francesca Santolla, Fedora Grande, Bruno Rizzuti, Marcello Maggiolini, Céline Gérard and Rosamaria Lappano
    Citation: Journal of Translational Medicine 2024 22:450
  50. The mesenchymal subtype of colorectal cancer (CRC), associated with poor prognosis, is characterized by abundant expression of the cellular prion protein PrPC, which represents a candidate therapeutic target. How...

    Authors: Sophie Mouillet-Richard, Angélique Gougelet, Bruno Passet, Camille Brochard, Delphine Le Corre, Caterina Luana Pitasi, Camille Joubel, Marine Sroussi, Claire Gallois, Julien Lavergne, Johan Castille, Marthe Vilotte, Nathalie Daniel-Carlier, Camilla Pilati, Aurélien de Reyniès, Fatima Djouadi…
    Citation: Journal of Translational Medicine 2024 22:337