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Translational Signaling and System Biology

Section edited by Marcello Maggiolini

© © selvanegra / Getty Images / iStock

The Translational Signaling and System Biology section aims to uncover pivotal transduction signaling involved in pathophysiological processes toward a translational impact on the discovery of novel targets and therapeutics. 

The section welcomes research and review articles providing new mechanistic insights on a broad range of fields such as cancer, cardiovascular biology, neuroscience, metabolism, inflammation, immunology, microbiology, drug action also through new formulations and delivery methods, novel cellular and animal models, computational and systems biology, innovative laboratory concepts fostering translational research from the bench to the bedside.

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  1. The mesenchymal subtype of colorectal cancer (CRC), associated with poor prognosis, is characterized by abundant expression of the cellular prion protein PrPC, which represents a candidate therapeutic target. How...

    Authors: Sophie Mouillet-Richard, Angélique Gougelet, Bruno Passet, Camille Brochard, Delphine Le Corre, Caterina Luana Pitasi, Camille Joubel, Marine Sroussi, Claire Gallois, Julien Lavergne, Johan Castille, Marthe Vilotte, Nathalie Daniel-Carlier, Camilla Pilati, Aurélien de Reyniès, Fatima Djouadi…
    Citation: Journal of Translational Medicine 2024 22:337
  2. Benign prostatic hyperplasia (BPH) is common in elder men. The current study aims to identify differentially expressed genes (DEGs) in hyperplastic prostate and to explore the role of Nik related kinase (NRK) ...

    Authors: Weixiang He, Zelin Tian, Bingchen Dong, Yitong Cao, Wei Hu, Peng Wu, Lei Yu, Xinhua Zhang and Shanshan Guo
    Citation: Journal of Translational Medicine 2024 22:255
  3. Circular RNAs (circRNAs) have been proved to play crucial roles in the development of various cancers. However, the molecular mechanism of circGLIS3 involved in gastric cancer (GC) tumorigenesis has not been e...

    Authors: Yongxin Zhang, Xiaofeng Wang, Wenwei Liu, Tianxiang Lei, Tang Qiao, Wei Feng and Wu Song
    Citation: Journal of Translational Medicine 2024 22:251
  4. Lung adenocarcinoma (LUAD) is the most common pathological type of lung cancer, but the early diagnosis rate is low. The RNA-binding ubiquitin ligase MEX3C promotes tumorigenesis in several cancers but its mec...

    Authors: Zelai He, Huijun Zhang, Haibo Xiao, Xiangyu Zhang, Hongbo Xu, Ruifen Sun and Siwen Li
    Citation: Journal of Translational Medicine 2024 22:216
  5. Lactylation, a novel contributor to post-translational protein modifications, exhibits dysregulation across various tumors. Nevertheless, its intricate involvement in colorectal carcinoma, particularly for non...

    Authors: Huixia Huang, Keji Chen, Yifei Zhu, Zijuan Hu, Yaxian Wang, Jiayu Chen, Yuxue Li, Dawei Li and Ping Wei
    Citation: Journal of Translational Medicine 2024 22:211
  6. Mitochondrial alterations, often dependent on unbalanced mitochondrial dynamics, feature in the pathobiology of human cancers, including multiple myeloma (MM). Flavanones are natural flavonoids endowed with mi...

    Authors: Roberta Torcasio, Maria Eugenia Gallo Cantafio, Claudia Veneziano, Carmela De Marco, Ludovica Ganino, Ilenia Valentino, Maria Antonietta Occhiuzzi, Ida Daniela Perrotta, Teresa Mancuso, Filomena Conforti, Bruno Rizzuti, Enrica Antonia Martino, Massimo Gentile, Antonino Neri, Giuseppe Viglietto, Fedora Grande…
    Citation: Journal of Translational Medicine 2024 22:208
  7. Castration-resistant prostate cancer (CRPC) is refractory to hormone treatment, and the underlying mechanism has not been fully elucidated. This study aimed to clarify the role and mechanism of Human antigen R...

    Authors: Hang You, Guojing Song, Zhizhen Xu, Saipeng Chen, Wenhao Shen, Heting Liu, Bingqian Deng, Jun Li and Gang Huang
    Citation: Journal of Translational Medicine 2024 22:178
  8. Several evidence demonstrated that glucagon-like peptide 1 receptor agonists (GLP1-RAs) reduce the risk of dementia in type 2 diabetes patients by improving memory, learning, and overcoming cognitive impairmen...

    Authors: Rosaria Anna Fontanella, Puja Ghosh, Ada Pesapane, Fatemeh Taktaz, Armando Puocci, Martina Franzese, Maria Federica Feliciano, Giovanni Tortorella, Lucia Scisciola, Eduardo Sommella, Concetta Ambrosino, Giuseppe Paolisso and Michelangela Barbieri
    Citation: Journal of Translational Medicine 2024 22:114
  9. Ovarian cancer poses a serious threat to women's health. Due to the difficulty of early detection, most patients are diagnosed with advanced-stage disease or peritoneal metastasis. We found that LncRNA MEG3 is...

    Authors: Yan Li, Shenghan Lou, Jian Zhang, Shilu Zhao and Ge Lou
    Citation: Journal of Translational Medicine 2024 22:113
  10. Non-alcoholic fatty liver disease (NAFLD) is a liver disorder characterized by the ac-cumulation of fat in hepatocytes without alcohol consumption. Mitochondrial dysfunction and endoplasmic reticulum (ER) stre...

    Authors: Lucia Longhitano, Alfio Distefano, Nicolò Musso, Paolo Bonacci, Laura Orlando, Sebastiano Giallongo, Daniele Tibullo, Simona Denaro, Giuseppe Lazzarino, Jessica Ferrigno, Anna Nicolosi, Amer M. Alanazi, Federico Salomone, Emanuela Tropea, Ignazio Alberto Barbagallo, Vincenzo Bramanti…
    Citation: Journal of Translational Medicine 2024 22:82
  11. Lung cancer is the most prevalent cancer worldwide, with non-small cell lung cancer (NSCLC) accounting for 85% of all cases. Circular RNAs(circRNA) play crucial roles in regulating the progression of lung canc...

    Authors: Jinbin Chen, Boqi Rao, Zeqin Huang, Chen Xie, Yonghui Yu, Binyao Yang, Di Wu, Dedong Wang, Fuman Qiu, Yifeng Zhou, Yibin Deng and Jiachun Lu
    Citation: Journal of Translational Medicine 2024 22:47
  12. Mucosal Melanomas (MM) are highly aggressive neoplasms arising from mucosal melanocytes. Current treatments offer a limited survival benefit for patients with advanced MM; moreover, the lack of pre-clinical ce...

    Authors: Matilde Monti, Luisa Benerini Gatta, Mattia Bugatti, Irene Pezzali, Sara Picinoli, Marcello Manfredi, Antonio Lavazza, Virginia Vita Vanella, Veronica De Giorgis, Lucia Zanatta, Francesco Missale, Silvia Lonardi, Benedetta Zanetti, Giovanni Bozzoni, Moris Cadei, Andrea Abate…
    Citation: Journal of Translational Medicine 2024 22:35
  13. Pancreatic ductal adenocarcinoma (PDAC) is characterized by rapid progression and poor prognosis. Understanding the genetic mechanisms that affect cancer properties and reprogram tumor immune microenvironment ...

    Authors: Wenbo Yang, Hongze Chen, Guanqun Li, Tao Zhang, Yuhang Sui, Liwei Liu, Jisheng Hu, Gang Wang, Hua Chen, Yongwei Wang, Xina Li, Hongtao Tan, Rui Kong, Bei Sun and Le Li
    Citation: Journal of Translational Medicine 2023 21:903
  14. Advanced prostate cancer (PCa) will develop into castration-resistant prostate cancer (CRPC) and lead to poor prognosis. As the primary subtype of CRPC, CRPC-AR accounts for the major induction of PCa heteroge...

    Authors: Maozhang Li, Guangwei Bai, Yi Cen, Qitong Xie, Jiahong Chen, Jia Chen, Qingbiao Chen, Weide Zhong and Xiaobo Zhou
    Citation: Journal of Translational Medicine 2023 21:884
  15. Breast cancer (BC) is a prevalent malignancy with complex etiology and varied clinical behavior. Long non-coding RNAs (lncRNAs) have emerged as key regulators in cancer progression, including BC. Among these, ...

    Authors: Yuqin Ding, Yuting Huang, Fanrong Zhang, Lijie Gong, Chenlu Liang, Kaijing Ding, Xiangming He, Xiaowen Ding and Yiding Chen
    Citation: Journal of Translational Medicine 2023 21:854
  16. Prostate cancer (PCa) is currently acknowledged as the second most widespread cancer among men worldwide. Yet, the lack of dependable diagnostic biomarkers and therapeutic targets has presented considerable hu...

    Authors: Lingxiang Lu, Fei Wang, Jianchun Chen, Chunchun Zhao, Shuai Guo, Da Dong, Minjun Jiang and Yuhua Huang
    Citation: Journal of Translational Medicine 2023 21:850
  17. Fibroblast growth factor receptor 1 (FGFR1) is a core component of the FGFs/FGFR pathway that activates multiple signalling pathways, including ERK1/2, PI3K/AKT, PLCγ, and NF-κB. Aberrant expression of FGFR1 due ...

    Authors: Ruyue Wang, Jinjing Zhong, Xiuyi Pan, Zhengzheng Su, Yunyi Xu, Mengni Zhang, Xueqin Chen, Ni Chen, Ting Yu and Qiao Zhou
    Citation: Journal of Translational Medicine 2023 21:840
  18. Protein palmitoylation, which is catalyzed by palmitoyl-transferase and de-palmitoyl-transferase, plays a crucial role in various biological processes. However, the landscape and dynamics of protein palmitoyla...

    Authors: Yue Kong, Yugeng Liu, Xianzhe Li, Menglan Rao, Dawei Li, Xiaolan Ruan, Shanglin Li, Zhenyou Jiang and Qiang Zhang
    Citation: Journal of Translational Medicine 2023 21:826
  19. Sirtuin 7 (SIRT7) is an oncogene that promotes tumor progression in various malignancies, however, its role and regulatory mechanism in cervical squamous cell carcinoma (CSCC) is unknown. Herein, we attempted ...

    Authors: Juanpeng Yu, Shuai Yuan, Jinglin Song and Shengsheng Yu
    Citation: Journal of Translational Medicine 2023 21:807
  20. Follicular thyroid cancer (FTC) is a prevalent form of differentiated thyroid cancer, whereas anaplastic thyroid cancer (ATC) represents a rare, fast-growing, undifferentiated, and highly aggressive tumor, pos...

    Authors: Simona D’Aprile, Simona Denaro, Anna Maria Pavone, Sebastiano Giallongo, Cesarina Giallongo, Alfio Distefano, Lucia Salvatorelli, Filippo Torrisi, Raffaella Giuffrida, Stefano Forte, Daniele Tibullo, Giovanni Li Volti, Gaetano Magro, Nunzio Vicario and Rosalba Parenti
    Citation: Journal of Translational Medicine 2023 21:780
  21. The phosphoinositide 3-kinase (PI3K)/AKT signaling pathway plays a crucial role in the pathogenesis of cancer. The dysregulation of this pathway has been linked to the development and initiation of various typ...

    Authors: Jie Liu, Xinyu Gu, Zhenjie Guan, Di Huang, Huiwu Xing and Lian Zheng
    Citation: Journal of Translational Medicine 2023 21:774
  22. Colorectal cancer (CRC) is the third most deadly and fourth most diagnosed cancer worldwide. Despite the progress in early diagnosis and advanced therapeutic options, CRC shows a poor prognosis with a 5 year s...

    Authors: Marzia Di Donato, Erika Di Zazzo, Annamaria Salvati, Carmela Sorrentino, Giorgio Giurato, Donatella Fiore, Maria Chiara Proto, Monica Rienzo, Amelia Casamassimi, Patrizia Gazzerro, Maurizio Bifulco, Gabriella Castoria, Alessandro Weisz, Giovanni Nassa and Ciro Abbondanza
    Citation: Journal of Translational Medicine 2023 21:736
  23. Androgen receptor (AR) activation and repression dual-functionality only became known recently and still remains intriguing in prostate cancer (PCa). MYC is a prominent oncogene that functionally entangles wit...

    Authors: Ju Guo, Zhao Wei, Tianwei Jia, Liyang Wang, Nuosu Nama, Jiaqian Liang, Xinghua Liao, Xiaming Liu, Yanfei Gao, Xiaoqiang Liu, Keshan Wang, Bin Fu and Shaoyong Shawn Chen
    Citation: Journal of Translational Medicine 2023 21:716
  24. Ubiquitination is one of the most significant post-translational modifications that regulate almost all physiological processes like cell proliferation, autophagy, apoptosis, and cell cycle progression. Contra...

    Authors: Kaiyi Niu, Yanlong Shi, Qingpeng Lv, Yizhu Wang, Jiping Chen, Wenning Zhang, Kung Feng and Yewei Zhang
    Citation: Journal of Translational Medicine 2023 21:665
  25. Sodium–glucose cotransporter 2 (SGLT2) inhibitors constitute the gold standard treatment for type 2 diabetes mellitus (T2DM). Among them, empagliflozin (EMPA) has shown beneficial effects against heart failure...

    Authors: Lucia Scisciola, Ugo Chianese, Vicky Caponigro, Manuela Giovanna Basilicata, Emanuela Salviati, Lucia Altucci, Pietro Campiglia, Giuseppe Paolisso, Michelangela Barbieri, Rosaria Benedetti and Eduardo Sommella
    Citation: Journal of Translational Medicine 2023 21:662
  26. Oncogene MYCN is closely related with malignant progression and poor prognosis of neuroblastoma (NB). Recently, long non-coding RNAs (lncRNAs) have been recognized as crucial regulators in various cancers. Howeve...

    Authors: Rui Yang, Nanjing Liu, Ting Li, Fangjie Liu, Jun Zhang, Hui Zhao, Lin Zou and Xiaoyan He
    Citation: Journal of Translational Medicine 2023 21:659
  27. The catenin beta 1 gene (CTNNB1) plays a crucial role in the malignant progression of various cancers. Recent studies have suggested that CTNNB1 hyperactivation is closely related to the occurrence and develop...

    Authors: Tao Liu, Meng-Qi Fan, Xiao-Xiao Xie, Qi-Peng Shu, Xue-Hua Du, Lin-Zhi Qi, Xiao-Dong Zhang, Ming-Hui Zhang, Guang Shan, Run-Lei Du and Shang-Ze Li
    Citation: Journal of Translational Medicine 2023 21:656
  28. Cancer is a complex disease with many contributing factors, and researchers have gained extensive knowledge that has helped them understand the diverse and varied nature of cancer. The altered patterns of DNA ...

    Authors: Chunjie Huang, Paniz Azizi, Masoud Vazirzadeh, Seyed Mohsen Aghaei-Zarch, Fatemehsadat Aghaei-Zarch, Jalaledin Ghanavi and Poopak Farnia
    Citation: Journal of Translational Medicine 2023 21:621
  29. Breast cancer (BC) as one of the most common causes of human deaths among women, is always considered one of the global health challenges. Despite various advances in diagnostic and therapeutic methods, a sign...

    Authors: Amirhosein Maharati and Meysam Moghbeli
    Citation: Journal of Translational Medicine 2023 21:556
  30. Neuroendocrine tumors (NETs) early diagnosis is a clinical challenge that require a deep understanding of molecular and genetic features of this heterogeneous group of neoplasms. However, few biomarkers exist ...

    Authors: Federica Campolo, Franz Sesti, Tiziana Feola, Giulia Puliani, Antongiulio Faggiano, Maria Grazia Tarsitano, Marta Tenuta, Valeria Hasenmajer, Elisabetta Ferretti, Monica Verrico, Daniele Gianfrilli, Mary Anna Venneri, Andrea M. Isidori and Elisa Giannetta
    Citation: Journal of Translational Medicine 2023 21:548
  31. Prostate cancer (PCa) is a prevalent malignant disease affecting a significant number of males globally. Elevated expression of the Bloom’s syndrome protein (BLM) helicase has emerged as a promising cancer bio...

    Authors: Mengqiu Huang, Lin Chen, Yingchu Guo, Yong Ruan and Houqiang Xu
    Citation: Journal of Translational Medicine 2023 21:445
  32. Cervical cancer (CC) has poor prognosis and high mortality rate for its metastasis during the disease progression. Epithelial-mesenchymal transition (EMT) and anoikis are initial and pivotal steps during the m...

    Authors: Mengwen Zhang, Xiaoling Hong, Ning Ma, Zhentong Wei, Xinxin Ci and Songling Zhang
    Citation: Journal of Translational Medicine 2023 21:433
  33. RP11-296E3.2 is a novel long noncoding RNA (lncRNA) associated with colorectal cancer (CRC) metastasis, that was reported in our previous clinical studies. However, the mechanisms of RP11-296E3.2 in colorectal...

    Authors: Qian Shi, Ying He, Shouyu He, Jingjing Li, Ji Xia, Tianwei Chen, Lixia Huo, Yuhang Ling, Qinchen Liu, Wei Zang, Qiang Wang, Chengwu Tang and Xiang Wang
    Citation: Journal of Translational Medicine 2023 21:418
  34. In recent decades, the incidence of thyroid cancer keeps growing at a shocking rate, which has aroused increasing concerns worldwide. Autophagy is a fundamental and ubiquitous biological event conserved in mam...

    Authors: Yu-Bo Shi, Shu-Yuan Chen and Ren-Bin Liu
    Citation: Journal of Translational Medicine 2023 21:413
  35. Accumulating data indicate that N6-methyladenosine (m6A) RNA methylation and lncRNA deregulation act crucial roles in cancer progression. Heterogeneous nuclear ribonucleoprotein A2B1 (HNRNPA2B1) as an m6A “reader...

    Authors: Ke Li, Quan Gong, Xu-Dong Xiang, Gang Guo, Jia Liu, Li Zhao, Jun Li, Nan Chen, Heng Li, Li-Juan Zhang, Chun-Yan Zhou, Zhi-Yong Wang and Li Zhuang
    Citation: Journal of Translational Medicine 2023 21:382
  36. The transcription factor family activator protein 2 (TFAP2) is vital for regulating both embryonic and oncogenic development. The TFAP2 family consists of five DNA-binding proteins, including TFAP2A, TFAP2B, T...

    Authors: Chen Jin, Yuxiao Luo, Zhu Liang, Xi Li, Damian Kołat, Linyong Zhao and Weixi Xiong
    Citation: Journal of Translational Medicine 2023 21:371
  37. Hepatocellular carcinoma (HCC) is the leading cause of cancer-related death in people, and a common primary liver cancer. Lacking early diagnosis and a high recurrence rate after surgical resection, systemic t...

    Authors: Yuan Fang, XiaoLi Zhang, HanFei Huang and Zhong Zeng
    Citation: Journal of Translational Medicine 2023 21:369
  38. Circular RNAs (circRNAs) are known to play a crucial role in a variety of malignancies. However, the precise role of circRNAs in cervical squamous cell carcinoma (CSCC) remains largely unknown.

    Authors: Wei Wang, Haixia Luo, Jingjing Chang, Xin Yang, Xiu Zhang, Qingmei Zhang, Yuanxing Li, Yueyang Zhao, Jianbing Liu, Binbin Zou and Min Hao
    Citation: Journal of Translational Medicine 2023 21:356
  39. Pronectins™ are a new class of fibronectin-3-domain 14th-derived (14Fn3) antibody mimics that can be engineered as bispecific T cell engager (BTCE) to redirect immune effector cells against cancer. We describe...

    Authors: Caterina Riillo, Nicoletta Polerà, Maria Teresa Di Martino, Giada Juli, Craig A. Hokanson, Tatjana Odineca, Stefania Signorelli, Katia Grillone, Serena Ascrizzi, Antonia Mancuso, Nicoletta Staropoli, Basilio Caparello, Maria Cerra, Giuseppe Nisticò, Pierosandro Tagliaferri, Roberto Crea…
    Citation: Journal of Translational Medicine 2023 21:301
  40. Circular RNAs (circRNAs) may regulate the onset and progression of human malignancies by competitively binding to microRNA (miRNA) sponges, thus regulating the downstream genes. However, aberrant circRNA expre...

    Authors: Huan Feng, Zhiyao Deng, Wei Peng, Xian Wei, Jihong Liu and Tao Wang
    Citation: Journal of Translational Medicine 2023 21:288
  41. Both dysregulation of mechanistic target of rapamycin (mTOR) signalling and DNA methylation patterns have been shown to be closely associated with tumor progression and serve as promising targets for hepatocel...

    Authors: Mengke Chen, Yi Fang, Meinong Liang, Ning Zhang, Xinyue Zhang, Lixia Xu, Xuxin Ren, Qingfeng Zhang, Yufeng Zhou, Sui Peng, Jun Yu, Judeng Zeng and Xiaoxing Li
    Citation: Journal of Translational Medicine 2023 21:276
  42. The incidence of obesity, a known risk factor for several metabolic and chronic diseases, including numerous malignancies, has risen sharply in the world. Various clinical studies demonstrate that excessive Bo...

    Authors: Ines Barone, Luca Gelsomino, Felice Maria Accattatis, Francesca Giordano, Balazs Gyorffy, Salvatore Panza, Mario Giuliano, Bianca Maria Veneziani, Grazia Arpino, Carmine De Angelis, Pietro De Placido, Daniela Bonofiglio, Sebastiano Andò, Cinzia Giordano and Stefania Catalano
    Citation: Journal of Translational Medicine 2023 21:232
  43. T cell activation and programming from their naïve/resting state, characterized by widespread modifications in chromatin accessibility triggering extensive changes in transcriptional programs, is orchestrated ...

    Authors: Erika Di Zazzo, Monica Rienzo, Amelia Casamassimi, Caterina De Rosa, Nicola Medici, Patrizia Gazzerro, Maurizio Bifulco and Ciro Abbondanza
    Citation: Journal of Translational Medicine 2023 21:217
  44. Gut microbiota modulation has been demonstrated to be effective in protecting patients against detrimental effects of anti-cancer therapies, as well as to improve the efficacy of certain anti-cancer treatments...

    Authors: Rossella Salemi, Silvia Vivarelli, Daria Ricci, Marina Scillato, Maria Santagati, Giuseppe Gattuso, Luca Falzone and Massimo Libra
    Citation: Journal of Translational Medicine 2023 21:195
  45. Breast cancer (BC) is a common malignant tumor in women worldwide. Circular RNA (circRNA) has been proven to play a critical role in BC progression. However, the exact biological functions and underlying mecha...

    Authors: Bin Wang, Hang Chen, Yumei Deng, Hong Chen, Lei Xing, Yuping Guo, Min Wang and Junxia Chen
    Citation: Journal of Translational Medicine 2023 21:186
  46. Breast cancer is the second leading cause of death among women after lung cancer. Despite the improvement in prevention and in therapy, breast cancer still remains a threat, both for pre- and postmenopausal wo...

    Authors: Francesca Giordano, Alessandro Paolì, Martina Forastiero, Stefania Marsico, Francesca De Amicis, Mariangela Marrelli, Giuseppina Daniela Naimo, Loredana Mauro and Maria Luisa Panno
    Citation: Journal of Translational Medicine 2023 21:165
  47. Breast cancer (BC) is the second most common cancer and cause of death in women. In recent years many studies investigated the association of long non-coding RNAs (lncRNAs), as novel genetic factors, on BC ris...

    Authors: Morteza Gholami, Zeynab Nickhah Klashami, Pirooz Ebrahimi, Amir Ali Mahboobipour, Amir Salehi Farid, Aida Vahidi, Marziyeh Zoughi, Mojgan Asadi and Mahsa M. Amoli
    Citation: Journal of Translational Medicine 2023 21:155
  48. Liver metastasis is the leading cause of death in patients with colorectal cancer (CRC). Surgical resection of the liver metastases increases the incidence of long-term survival in patients with colorectal liv...

    Authors: Xiangdong Li, Ziyi Wang, Chenyu Jiao, Yu Zhang, Nan Xia, Wenjie Yu, Xuejiao Chen, Likalamu Pascalia Wikana, Yue Liu, Linfeng Sun, Minhao Chen, Yuhao Xiao, Yuhua Shi, Sheng Han and Liyong Pu
    Citation: Journal of Translational Medicine 2023 21:121