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Personalized medicine

Section edited by Lotfi Chouchane

This section aims to provide a platform for research that will revolutionize patient care through the use of novel molecular predisposing screening, diagnostic, prognostic and pharmacogenomics. Advances in human genome research are opening the door to a new paradigm for practicing medicine that promises to transform healthcare. Personalized medicine will impact the way that medicine is practiced.

Featured articles

Pharmacogenetics driving personalized medicine: analysis of genetic polymorphisms related to breast cancer medications in Italian isolated populations
Massimiliano Cocca, et al

Anti-cytokine autoantibodies in postherpetic neuralgia
Ahmad Bayat, et al



Comprehensive molecular characterization of human adipocytes reveals a transient brown phenotype
Andrea Guennoun, et al

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  1. The pathogenesis of osteoporosis involves multiple factors, among which alterations in the bone microenvironment play a crucial role in disrupting normal bone metabolic balance. Transient receptor potential va...

    Authors: Zhi-heng Luo, Jian-xiong Ma, Wei Zhang, Ai-xian Tian, Shu-wei Gong, Yan Li, Yu-xiao Lai and Xin-long Ma
    Citation: Journal of Translational Medicine 2023 21:327
    Content type: Review Published on:

  2. Polymorphisms in microRNAs (miRNAs) play an important role in acute coronary syndromes (ACS). The purpose of this study was to assess the association of miR-146a rs2910164 and miR-34b rs4938723 polymorphisms w...

    Authors: Xiang-Rui Qiao, Tao Zheng, Yifei Xie, Xinyi yao, Zuyi Yuan, Yue Wu, Dong Zhou and Tao Chen
    Citation: Journal of Translational Medicine 2023 21:325
    Content type: Research Published on:

  3. Despite the wide variety of Next Generation Sequencing (NGS)-based methods, it remains challenging to detect mutations present at very low frequencies. This problem is particularly relevant in oncology, where ...

    Authors: Jonathan Bieler, Slawomir Kubik, Morgane Macheret, Christian Pozzorini, Adrian Willig and Zhenyu Xu
    Citation: Journal of Translational Medicine 2023 21:305
    Content type: Research Published on:

  4. Irritable bowel syndrome (IBS) is a chronic disorder of gut-brain interaction frequently accompanied by mental conditions, including depression and anxiety. Despite showing substantial heritability and being p...

    Authors: Silvia Alemany, María Soler-Artigas, Judit Cabana-Domínguez, Dana Fakhreddine, Natalia Llonga, Laura Vilar-Ribó, Amanda Rodríguez-Urrutia, Judit Palacio, Ana María González-Castro, Beatriz Lobo, Carmen Alonso-Cotoner, Magnus Simrén, Javier Santos, Josep Antoni Ramos-Quiroga and Marta Ribasés
    Citation: Journal of Translational Medicine 2023 21:272
    Content type: Research Published on:

  5. The incidence of pediatric inflammatory bowel disease (PIBD) has been steadily increasing globally. Delayed diagnosis of PIBD increases the risk of complications and contributes to growth retardation. To impro...

    Authors: Xixi Chen, Yuanqi Gao, Jinfang Xie, Huiying Hua, Chun Pan, Jiebin Huang, Mengxia Jing, Xuehua Chen, Chundi Xu, Yujing Gao and Pu Li
    Citation: Journal of Translational Medicine 2023 21:203
    Content type: Research Published on:

  6. Osteoporosis is highly polygenic and heritable, with heritability ranging from 50 to 80%; most inherited susceptibility is associated with the cumulative effect of many common genetic variants. However, existi...

    Authors: Qing Wu and Jongyun Jung
    Citation: Journal of Translational Medicine 2023 21:127
    Content type: Research Published on:

  7. Multiple system atrophy (MSA) is a heterogenous, uniformly fatal neurodegenerative ɑ-synucleinopathy. Patients present with varying degrees of dysautonomia, parkinsonism, cerebellar dysfunction, and corticospi...

    Authors: Fan Shuen Tseng, Joel Qi Xuan Foo, Aaron Shengting Mai and Eng-King Tan
    Citation: Journal of Translational Medicine 2023 21:104
    Content type: Review Published on:

  8. The popular statistics-based Genome-wide association studies (GWAS) have provided deep insights into the field of complex disorder genetics. However, its clinical applicability to predict disease/trait outcome...

    Authors: Ashley J. W. Lim, C. Tera Tyniana, Lee Jin Lim, Justina Wei Lynn Tan, Ee Tzun Koh, Samuel S. Chong, Chiea Chuen Khor, Khai Pang Leong and Caroline G. Lee
    Citation: Journal of Translational Medicine 2023 21:92
    Content type: Research Published on:

  9. Obesity is a major health concern for breast cancer survivors, being associated with high recurrence and reduced efficacy during cancer treatment. Metformin treatment is associated with reduced breast cancer i...

    Authors: Federica Bellerba, Anastasia Chrysovalantou Chatziioannou, Paniz Jasbi, Nivonirina Robinot, Pekka Keski-Rahkonen, Amarine Trolat, Béatrice Vozar, Sheri J. Hartman, Augustin Scalbert, Bernardo Bonanni, Harriet Johansson, Dorothy D. Sears and Sara Gandini
    Citation: Journal of Translational Medicine 2022 20:629
    Content type: Research Published on:

  10. Genome-wide association studies (GWAS) have identified some variants associated with subclinical atherosclerosis (SCA) in general population but lacking sufficient validation. Besides traditional risk factors,...

    Authors: Jiayu He, Haijiang Lin, Yingying Ding, Xing Liu, Kelin Xu, Xiaoxiao Chen, Weiwei Shen, Sujuan Zhou, Miaochen Wang, Jingjing Xia and Na He
    Citation: Journal of Translational Medicine 2022 20:609
    Content type: Research Published on:

  11. Ankylosing spondylitis (AS) is an autoimmune disease affecting mainly spine and sacroiliac joints and adjacent soft tissues. Genome-wide association studies (GWASs) are used to evaluate genetic associations an...

    Authors: Ching-Lung Ko, Wei-Zhi Lin, Meng-Ting Lee, Yu-Tien Chang, Hung-Che Lin, Yi-Syuan Wu, Jun-Fu Lin, Ke-Ting Pan, Yu-Chuan Chang, Ko-Han Lee, Yi-Lun Lee, Tsung-Ting Hsieh, Jia-Hsin Huang, Chih-Hung Wang, Sung-Sen Yang, Hsiang-Cheng Chen…
    Citation: Journal of Translational Medicine 2022 20:589
    Content type: Research Published on:

  12. Genetic risk factors for chemotherapy-induced peripheral neuropathy (CIPN), a major dose-limiting side-effect of paclitaxel, are not well understood.

    Authors: Kosar Hooshmand, David Goldstein, Hannah C. Timmins, Tiffany Li, Michelle Harrison, Michael L. Friedlander, Craig R. Lewis, Justin G. Lees, Gila Moalem-Taylor, Boris Guennewig, Susanna B. Park and John B. Kwok
    Citation: Journal of Translational Medicine 2022 20:564
    Content type: Research Published on:

  13. Pharmacogenomics (PGx) aims to utilize a patient’s genetic data to enable safer and more effective prescribing of medications. The Clinical Pharmacogenetics Implementation Consortium (CPIC) provides guidelines...

    Authors: Shefali S. Verma, Karl Keat, Binglan Li, Glenda Hoffecker, Marjorie Risman, Katrin Sangkuhl, Michelle Whirl-Carrillo, Scott Dudek, Anurag Verma, Teri E. Klein, Marylyn D. Ritchie and Sony Tuteja
    Citation: Journal of Translational Medicine 2022 20:550
    Content type: Research Published on:

  14. Previous studies on European (EUR) samples have obtained inconsistent results regarding the genetic correlation between type 2 diabetes mellitus (T2DM) and Schizophrenia (SCZ). A large-scale trans-ethnic genet...

    Authors: Lei Cai, Yanlan Sun, Yonglin Liu, Wenzhong Chen, Lin He and Dong-Qing Wei
    Citation: Journal of Translational Medicine 2022 20:501
    Content type: Research Published on:

  15. Homologous recombination deficiency (HRD) is closely associated with patient prognosis and treatment options in prostate cancer (PCa). However, there is a lack of quantitative indicators related to HRD to pred...

    Authors: Cong Luo, Zhi Liu, Yu Gan, Xiaomei Gao, Xiongbing Zu, Ye Zhang, Wenrui Ye and Yi Cai
    Citation: Journal of Translational Medicine 2022 20:313
    Content type: Research Published on:

  16. Comitant strabismus (CS) is a heterogeneous disorder that is a major contributing factor to unilateral childhood-onset visual impairment. Studies have confirmed that genetic factors play an important role in t...

    Authors: Yue Wang, Xuejuan Chen, Tao Jiang, Yayun Gu, Xiaohan Zhang, Wenwen Yuan, Andi Zhao, Rui Li, Zijin Wang, Zhibin Hu and Hu Liu
    Citation: Journal of Translational Medicine 2021 19:495
    Content type: Research Published on:

  17. Colorectal carcinoma (CRC) harboring oncogenic fusions has been reported to be highly enriched in mismatch repair deficient (dMMR) tumors with MLH1 hypermethylation (MLH1me+) and wild-type BRAF and RAS. In this s...

    Authors: Jing Wang, Ruiyu Li, Junjie Li, Yuting Yi, Xiaoding Liu, Jingci Chen, Hui Zhang, Junliang Lu, Cami Li, Huanwen Wu and Zhiyong Liang
    Citation: Journal of Translational Medicine 2021 19:433
    Content type: Research Published on:

  19. Integrating functional annotations into SNP-set association studies has been proven a powerful analysis strategy. Statistical methods for such integration have been developed for continuous and binary phenotyp...

    Authors: Haojie Lu, Yongyue Wei, Zhou Jiang, Jinhui Zhang, Ting Wang, Shuiping Huang and Ping Zeng
    Citation: Journal of Translational Medicine 2021 19:418
    Content type: Research Published on:

  21. Pancreatic ductal adenocarcinoma (PDAC) is a fatal disease with molecular heterogeneity, inducing differences in biological behavior, and therapeutic strategy. NGS profiles of pathogenic alterations in the Chi...

    Authors: Lin Shui, Xiaofen Li, Yang Peng, Jiangfang Tian, Shuangshuang Li, Du He, Ang Li, Bole Tian, Mao Li, Heli Gao, Ning An, Cheng Yi and Dan Cao
    Citation: Journal of Translational Medicine 2021 19:301
    Content type: Research Published on:

    The Correction to this article has been published in Journal of Translational Medicine 2021 19:345

  22. Infections are a major disease burden worldwide. While they are caused by external pathogens, host genetics also plays a part in susceptibility to infections. Past studies have reported diverse associations be...

    Authors: Ron Nudel, Rosa Lundbye Allesøe, Wesley K. Thompson, Thomas Werge, Simon Rasmussen and Michael E. Benros
    Citation: Journal of Translational Medicine 2021 19:230
    Content type: Research Published on:

  23. Type 1 diabetes affects millions of people globally and requires careful management to avoid serious long-term complications, including heart and kidney disease, stroke, and loss of sight. The type 1 diabetes ...

    Authors: Ammira Al-Shabeeb Akil, Esraa Yassin, Aljazi Al-Maraghi, Elbay Aliyev, Khulod Al-Malki and Khalid A. Fakhro
    Citation: Journal of Translational Medicine 2021 19:137
    Content type: Review Published on:

  24. The incidence of breast cancer (BC) and/or ovarian cancer (OC) is increasing in Tunisia especially in young women and mostly those with family history. However, the spectrum of BRCA mutations remains little explo...

    Authors: Dorra Ben Ayed-Guerfali, Wala Ben Kridis-Rejab, Nihel Ammous-Boukhris, Wajdi Ayadi, Slim Charfi, Afef Khanfir, Tahia Sellami-Boudawara, Mounir Frikha, Jamel Daoud and Raja Mokdad-Gargouri
    Citation: Journal of Translational Medicine 2021 19:108
    Content type: Research Published on:

  25. Hypertension (HTN), diabetes mellitus (DM), and dyslipidemia (DL) are well-known risk factors of cardiovascular disease (CVD), but not all patients develop CVDs. Studies have been limited investigating genetic...

    Authors: Youhyun Song, Ja-Eun Choi, Yu-Jin Kwon, Hyuk-Jae Chang, Jung Oh Kim, Da-Hyun Park, Jae-Min Park, Seong-Jin Kim, Ji Won Lee and Kyung-Won Hong
    Citation: Journal of Translational Medicine 2021 19:85
    Content type: Research Published on:

  26. Melanoma is the deadliest of skin cancers and has an increasing annual incidence worldwide. It is a multi-factorial disease most likely arising from both genetic predisposition and environmental exposure to ul...

    Authors: Clara Benna, Senthilkumar Rajendran, Giovanna Spiro, Chiara Menin, Luigi Dall’Olmo, Carlo Riccardo Rossi and Simone Mocellin
    Citation: Journal of Translational Medicine 2021 19:57
    Content type: Research Published on:

  27. Genome-wide association studies have identified thousands of disease-associated single nucleotide polymorphisms (SNPs). A subset of these SNPs may be additively combined to generate genetic risk scores (GRSs) ...

    Authors: Carly A. Conran, Zhuqing Shi, William Kyle Resurreccion, Rong Na, Brian T. Helfand, Elena Genova, Siqun Lilly Zheng, Charles B. Brendler and Jianfeng Xu
    Citation: Journal of Translational Medicine 2021 19:41
    Content type: Research Published on:

  28. Aberrant metabolism is the root cause of several serious health issues, creating a huge burden to health and leading to diminished life expectancy. A dysregulated metabolism induces the secretion of several mo...

    Authors: Murugan Subramanian, Anne Wojtusciszyn, Lucie Favre, Sabri Boughorbel, Jingxuan Shan, Khaled B. Letaief, Nelly Pitteloud and Lotfi Chouchane
    Citation: Journal of Translational Medicine 2020 18:472
    Content type: Review Published on:

  29. The outbreak of coronavirus disease (COVID-19) was caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), through its surface spike glycoprotein (S-protein) recognition on the receptor Angiote...

    Authors: Xingyi Guo, Zhishan Chen, Yumin Xia, Weiqiang Lin and Hongzhi Li
    Citation: Journal of Translational Medicine 2020 18:321
    Content type: Research Published on:

  30. Conotruncal defects (CTDs) are a type of heterogeneous congenital heart diseases (CHDs), but little is known about their etiology. Increasing evidence has demonstrated that fibroblast growth factor (FGF) 8 and...

    Authors: Shuang Zhou, Qingjie Wang, Zhuo Meng, Jiayu Peng, Yue Zhou, Wenting Song, Jian Wang, Sun Chen and Kun Sun
    Citation: Journal of Translational Medicine 2020 18:283
    Content type: Research Published on:

  31. In the context of our Regional Program of Hereditary Cancer, individuals fulfilling the criteria are tested for germline mutations to subsequently establish the clinical management. Our standard diagnostic app...

    Authors: Carolina Velázquez, Enrique Lastra, Francisco Avila Cobos, Luis Abella, Virginia de la Cruz, Blanca Ascensión Hernando, Lara Hernández, Noemí Martínez, Mar Infante and Mercedes Durán
    Citation: Journal of Translational Medicine 2020 18:232
    Content type: Research Published on:

  32. Radiation-induced oral mucositis (OM) is one of the most common acute complications for head and neck cancer. Severe OM is associated with radiation treatment breaks, which harms successful tumor management. R...

    Authors: Da-Wei Yang, Tong-Min Wang, Jiang-Bo Zhang, Xi-Zhao Li, Yong-Qiao He, Ruowen Xiao, Wen-Qiong Xue, Xiao-Hui Zheng, Pei-Fen Zhang, Shao-Dan Zhang, Ye-Zhu Hu, Guo-Ping Shen, Mingyuan Chen, Ying Sun and Wei-Hua Jia
    Citation: Journal of Translational Medicine 2020 18:224
    Content type: Research Published on:

  33. Malignant serous effusion (MSE) denotes a manifestation of metastatic disease with typical high concentrations of both cancer and immune cells, making them an ideal resource for in vitro cytologic studies. Hen...

    Authors: Cheng-Guang Wu, Francesca Chiovaro, Alessandra Curioni-Fontecedro, Ruben Casanova and Alex Soltermann
    Citation: Journal of Translational Medicine 2020 18:163
    Content type: Research Published on:

  34. Immune checkpoint inhibitors are effective in some cases of lung adenocarcinoma (LUAD). Whole-exome sequencing has revealed that the tumour mutation burden (TMB) is associated with clinical benefits among pati...

    Authors: Ying Li, Wenbin Jiang, Tianhao Li, Mengyue Li, Xin Li, Zheyang Zhang, Sainan Zhang, Yixin Liu, Wenyuan Zhao, Yunyan Gu, Lishuang Qi, Lu Ao and Zheng Guo
    Citation: Journal of Translational Medicine 2020 18:25
    Content type: Research Published on:

  35. The 18-gene tumor inflammation signature (TIS) is a clinical research assay that enriches for clinical benefit to immune checkpoint blockade. We evaluated its ability to predict clinical benefit of immunothera...

    Authors: Diane Damotte, Sarah Warren, Jennifer Arrondeau, Pascaline Boudou-Rouquette, Audrey Mansuet-Lupo, Jérôme Biton, Hanane Ouakrim, Marco Alifano, Claire Gervais, Audrey Bellesoeur, Nora Kramkimel, Camille Tlemsani, Barbara Burroni, Angéline Duche, Franck Letourneur, Han Si…
    Citation: Journal of Translational Medicine 2019 17:357
    Content type: Research Published on:

  36. Obesity is associated with an increased risk of insulin resistance and type 2 diabetes mellitus (T2DM). However, some obese individuals maintain their insulin sensitivity and exhibit a lower risk of associated...

    Authors: Haya Al-Sulaiti, Ilhame Diboun, Maha V. Agha, Fatima F. S. Mohamed, Stephen Atkin, Alex S. Dömling, Mohamed A. Elrayess and Nayef A. Mazloum
    Citation: Journal of Translational Medicine 2019 17:348
    Content type: Research Published on:

  37. Liquid biopsy based on cell-free DNA circulating in plasma has shown solid results as a non-invasive biomarker. In the present study we evaluated the utility of circulating free DNA (cfDNA) and the sub-type tu...

    Authors: Marianna Alunni-Fabbroni, Kerstin Rönsch, Thomas Huber, Clemens C. Cyran, Max Seidensticker, Julia Mayerle, Maciej Pech, Bristi Basu, Chris Verslype, Julia Benckert, Peter Malfertheiner and Jens Ricke
    Citation: Journal of Translational Medicine 2019 17:328
    Content type: Research Published on:

  38. Minimal hepatic encephalopathy (MHE) in cirrhotic patients is associated with specific changes in parameters of the immune system reflecting a more pro-inflammatory environment than in patients without MHE. Th...

    Authors: Alba Mangas-Losada, Raquel García-García, Paola Leone, María Pilar Ballester, Andrea Cabrera-Pastor, Amparo Urios, Juan-José Gallego, Juan-José Martínez-Pretel, Carla Giménez-Garzó, Fernando Revert, Desamparados Escudero-García, Joan Tosca, María Pilar Ríos, Cristina Montón, Lucia Durbán, Luis Aparicio…
    Citation: Journal of Translational Medicine 2019 17:293
    Content type: Research Published on:

  39. Pituitary adenomas are common brain tumors. Although transsphenoidal surgery are able to achieve extensive tumor removal, the rate of recurrence ranges from 5 to 20% depending on the different subtype. Further...

    Authors: Jie Feng, Hua Gao, Qi Zhang, Yang Zhou, Chuzhong Li, Sida Zhao, Lichuan Hong, Jinjin Yang, Shuyu Hao, Wan Hong, Zhengping Zhuang, Guowang Xu and Yazhuo Zhang
    Citation: Journal of Translational Medicine 2019 17:291
    Content type: Research Published on:

  40. Currently, in vivo model for personalised cancer drug testing is challenging. A zebrafish larvae xenograft model has been applied in recent years to cancer research, particularly for drug testing purposes, sho...

    Authors: Ahmed Al-Samadi, Katja Tuomainen, Anne Kivimäki, Abdelhakim Salem, Sakhr Al-Kubati, Aini Hyytiäinen, Mataleena Parikka, Karri Mesimäki, Tommy Wilkman, Antti Mäkitie, Reidar Grenman and Tuula Salo
    Citation: Journal of Translational Medicine 2019 17:235
    Content type: Research Published on:

  41. Diabetes is a chronic disease associated with many problems and high costs. In recent decades, a lot of research has been carried out in order to improve methods of treatment of diabetic patients. One of the c...

    Authors: Fouad Mehraban, Arefeh Seyedarabi, Shahin Ahmadian, Vahid Mirzaaghaei and Ali Akbar Moosavi-Movahedi
    Citation: Journal of Translational Medicine 2019 17:227
    Content type: Research Published on:

  42. The influence of DNMT3A R882 mutations on adult acute myeloid leukemia (AML) prognosis is still controversial presently. The influence of R882 allele ratio on drug response and prognosis of AML is unknown yet. Be...

    Authors: Xiao-Qing Yuan, Peng Chen, Yin-Xiao Du, Ke-Wei Zhu, Dao-Yu Zhang, Han Yan, Han Liu, Yan-Ling Liu, Shan Cao, Gan Zhou, Hui Zeng, Shu-Ping Chen, Xie-Lan Zhao, Jing Yang, Wen-Jing Zeng and Xiao-Ping Chen
    Citation: Journal of Translational Medicine 2019 17:220
    Content type: Research Published on:

  43. Rupture of an intracranial aneurysm (IA) causes a systemic response that involves an immune/inflammatory reaction. Our previous study revealed a downregulation of genes related to T lymphocytes and an upregula...

    Authors: Michal Korostynski, Marcin Piechota, Rafal Morga, Dzesika Hoinkis, Slawomir Golda, Magdalena Zygmunt, Tomasz Dziedzic, Marek Moskala, Agnieszka Slowik and Joanna Pera
    Citation: Journal of Translational Medicine 2019 17:141
    Content type: Research Published on:

  44. Over the past few years, next-generation sequencing (NGS) has become reliable and cost-effective, and its use in clinical practice has become a reality. A relevant role for NGS is the prediction of response to...

    Authors: Edoardo Isnaldi, Anna Garuti, Gabriella Cirmena, Stefano Scabini, Edoardo Rimini, Lorenzo Ferrando, Michela Lia, Roberto Murialdo, Lucia Tixi, Enrico Carminati, Andrea Panaro, Maurizio Gallo, Federica Grillo, Luca Mastracci, Lazzaro Repetto, Roberto Fiocca…
    Citation: Journal of Translational Medicine 2019 17:137
    Content type: Research Published on:

  45. The dynein axonemal heavy chain (DNAH) family of genes encode the dynein axonemal heavy chain, which is involved in cell motility. Genomic variations of DNAH family members have been frequently reported in div...

    Authors: Chunchao Zhu, Qin Yang, Jia Xu, Wenyi Zhao, Zizhen Zhang, Danhua Xu, Yeqian Zhang, Enhao Zhao and Gang Zhao
    Citation: Journal of Translational Medicine 2019 17:109
    Content type: Research Published on:

  46. SETD2, the single mediator of trimethylation of histone 3 at position lysine 36, has been reported associated with initiation progression and chemotherapy resistance in acute myeloid leukemia (AML). Whether polym...

    Authors: Suwei Wang, Xiaoqing Yuan, Yazhen Liu, Kewei Zhu, Peng Chen, Han Yan, Daoyu Zhang, Xi Li, Hui Zeng, Xielan Zhao, Xiaoping Chen, Gan Zhou and Shan Cao
    Citation: Journal of Translational Medicine 2019 17:101
    Content type: Research Published on:

  48. MET amplification is associated with acquired resistance to first-generation epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitors (TKIs) in treating non-small-cell lung cancer (NSCLC); however, t...

    Authors: Wenxian Wang, Hong Wang, Peihua Lu, Zongyang Yu, Chunwei Xu, Wu Zhuang and Zhengbo Song
    Citation: Journal of Translational Medicine 2019 17:52
    Content type: Research Published on:

  49. Patients with Idiopathic membranous nephropathy (IMN) have various outcomes. The aim of this study is to construct a tool for clinicians to precisely predict outcome of IMN.

    Authors: Hu Xiaofan, Xu Jing, Gao Chenni, Wu Yifan, Yu Xialian, Lin Li, Ren Hong, Zhang Wen, Wang Weiming, Pan Xiaoxia, Xie Jingyuan and Chen Nan
    Citation: Journal of Translational Medicine 2019 17:41
    Content type: Research Published on:

  50. Among breast cancer (BC) patients, near 40% are post-menopause, and 70%–80% are hormone receptor (HR)-positive. About 30%–40% BC patients who are diagnosed as invasive carcinoma HR-positive BC would eventually...

    Authors: Jingyu Liu, Jing Li, Hui Wang, Yikai Wang, Qiongzhi He, Xuefeng Xia, Zhe-Yu Hu and Quchang Ouyang
    Citation: Journal of Translational Medicine 2019 17:27
    Content type: Research Published on:
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