Skip to main content

Computational modelling and Epidemiology

Section edited by Michael N. Liebman and Sabrina Molinaro

This section aims to allow rapid communication of methods and results that utilize computational modeling and epidemiologic approaches in translational medicine. The focus will be on population-based studies that extend towards more molecular level analysis. 

Submission of studies involving methods development is encouraged where actual application and results can be shown in the healthcare and life sciences domains. Among the approaches highlighted in this section are data-mining for health impact, data modeling, health record system design, applications of epidemiologic analysis, public policy evaluation, hypothesis evaluation and testing, risk assessment in healthcare and life sciences. These articles will describe the perspective on translational medicine where the approach and results reflect the computational modeling and epidemiologic aspects of this emerging area of research.

Featured articles

Impact of lockdown on Covid-19 case fatality rate and viral mutations spread in 7 countries in Europe and North America

Research | Maria Pachetti et al

Analysis of SARS-CoV-2 RNA-dependent RNA polymerase as a potential therapeutic drug target using a computational approach

Research | Syed Ovais Aftab et al


The effects of statins on dental and oral health: a review of preclinical and clinical studies

Review | Shabnam Tahamtan et al

Page 2 of 6

  1. Non-alcoholic fatty liver disease (NAFLD) shares common risk factors with cardiovascular diseases. Effects of longitudinal trends in non-high-density lipoprotein (non-HDL) cholesterol on NAFLD development are ...

    Authors: Jun-Hyuk Lee, Jiyeon Kim, Jung Oh Kim and Yu-Jin Kwon
    Citation: Journal of Translational Medicine 2023 21:435
  2. Colonoscopy is a useful as a cancer screening test. However, in countries with limited medical resources, there are restrictions on the widespread use of endoscopy. Non-invasive screening methods to determine ...

    Authors: Kohjiro Tokutake, Aaron Morelos-Gomez, Ken-ichi Hoshi, Michio Katouda, Syogo Tejima and Morinobu Endo
    Citation: Journal of Translational Medicine 2023 21:431
  3. Acute kidney injury (AKI) is a common complication in critically ill patients with sepsis and is often associated with a poor prognosis. We aimed to construct and validate an interpretable prognostic predictio...

    Authors: Zhiyan Fan, Jiamei Jiang, Chen Xiao, Youlei Chen, Quan Xia, Juan Wang, Mengjuan Fang, Zesheng Wu and Fanghui Chen
    Citation: Journal of Translational Medicine 2023 21:406
  4. Breast cancer brain metastases (BCBM) are the most fatal, with limited survival in all breast cancer distant metastases. These patients are deemed to be incurable. Thus, survival time is their foremost concern...

    Authors: Chaofan Li, Mengjie Liu, Yinbin Zhang, Yusheng Wang, Jia Li, Shiyu Sun, Xuanyu Liu, Huizi Wu, Cong Feng, Peizhuo Yao, Yiwei Jia, Yu Zhang, Xinyu Wei, Fei Wu, Chong Du, Xixi Zhao…
    Citation: Journal of Translational Medicine 2023 21:404
  5. Autism spectrum disorder (ASD) is a neurodevelopmental disorder that is difficult to diagnose. Inflammatory bowel disease (IBD) is a common chronic digestive disease. Previous studies have shown a potential co...

    Authors: Jinyi Zhu, Haoran Meng, Li Zhang and Yan Li
    Citation: Journal of Translational Medicine 2023 21:372
  6. Novel human epidermal growth factor receptor 2 (HER2)-directed antibody–drug conjugates prompt the identification of the HER2-low subtype. However, the biological significance of HER2-low expression in breast ...

    Authors: Juan Jin, Bin Li, Jianing Cao, Ting Li, Jian Zhang, Jun Cao, Mingchuan Zhao, Leiping Wang, Biyun Wang, Zhonghua Tao and Xichun Hu
    Citation: Journal of Translational Medicine 2023 21:360
  7. Chronic kidney disease (CKD) is one of the most significant cardiovascular risk factors, playing vital roles in various cardiovascular diseases such as calcific aortic valve disease (CAVD). We aim to explore t...

    Authors: Enyi Zhu, Xiaorong Shu, Zi Xu, Yanren Peng, Yunxiu Xiang, Yu Liu, Hui Guan, Ming Zhong, Jinhong Li, Li-Zhen Zhang, Ruqiong Nie and Zhihua Zheng
    Citation: Journal of Translational Medicine 2023 21:359
  8. Osteoarthritis (OA) is one of the most prevalent musculoskeletal diseases and is the leading cause of pain and disability in the aged population. However, the underlying biological mechanism has not been fully...

    Authors: Yifei Gu, Qianmei Jin, Jinquan Hu, Xinwei Wang, Wenchao Yu, Zhanchao Wang, Chen Wang, Yang Liu, Yu Chen and Wen Yuan
    Citation: Journal of Translational Medicine 2023 21:357
  9. Carotid atherosclerosis (CAS), an important factor in the development of stroke, is a major public health concern. The aim of this study was to establish and validate machine learning (ML) models for early scr...

    Authors: Ke Yun, Tao He, Shi Zhen, Meihui Quan, Xiaotao Yang, Dongliang Man, Shuang Zhang, Wei Wang and Xiaoxu Han
    Citation: Journal of Translational Medicine 2023 21:353
  10. The current ageing trend of the world population has, in part, accounted for Alzheimer disease (AD) being a public health issue in recent times. Although some progress has been made in clarifying AD-related pa...

    Authors: Benson O. A. Botchway, Xuehong Liu, Yu Zhou and Marong Fang
    Citation: Journal of Translational Medicine 2023 21:351
  11. Clear cell renal cell carcinoma (ccRCC) is a highly invasive and metastatic subtype of kidney malignancy and is correlated with metabolic reprogramming for adaptation to the tumor microenvironment comprising i...

    Authors: Hansen Lin, Liangmin Fu, Pengju Li, Jiangquan Zhu, Quanhui Xu, Yinghan Wang, Mukhtar Adan Mumin, Xinwei Zhou, Yuhang Chen, Guannan Shu, Gaosheng Yao, Minyu Chen, Jun Lu, Lizhen Zhang, YuJun Liu, Yiqi Zhao…
    Citation: Journal of Translational Medicine 2023 21:343
  12. The Swedish Childhood Tumor Biobank (BTB) is a nonprofit national infrastructure for collecting tissue samples and genomic data from pediatric patients diagnosed with central nervous system (CNS) and other sol...

    Authors: Teresita Díaz de Ståhl, Alia Shamikh, Markus Mayrhofer, Szilvester Juhos, Elisa Basmaci, Gabriela Prochazka, Maxime Garcia, Praveen Raj Somarajan, Katarzyna Zielinska-Chomej, Christopher Illies, Ingrid Øra, Peter Siesjö, Per-Erik Sandström, Jakob Stenman, Magnus Sabel, Bengt Gustavsson…
    Citation: Journal of Translational Medicine 2023 21:342
  13. It is known that measuring the triglyceride glucose (TyG) index and TyG-related parameters [triglyceride glucose-body mass index (TyG-BMI), triglyceride glucose-waist circumference (TyG-WC), and triglyceride g...

    Authors: Maobin Kuang, Ruijuan Yang, Xin Huang, Chao Wang, Guotai Sheng, Guobo Xie and Yang Zou
    Citation: Journal of Translational Medicine 2023 21:299
  14. The growing epidemic of the inflammation-related metabolic disease, type 2 diabetes mellitus, presents a challenge to improve our understanding of potential mechanisms or biomarkers to prevent or better contro...

    Authors: Nicole Noren Hooten, Nicolle A. Mode, Edward Kowalik, Victor Omoniyi, Alan B. Zonderman, Ngozi Ezike, Mark J. DiNubile, Susan L. Levinson and Michele K. Evans
    Citation: Journal of Translational Medicine 2023 21:190
  15. Circadian rhythm regulates complex physiological activities in organisms. A strong link between circadian dysfunction and cancer has been identified. However, the factors of dysregulation and functional signif...

    Authors: Yuwei Liu, Shuang Guo, Yue Sun, Caiyu Zhang, Jing Gan, Shangwei Ning and Junwei Wang
    Citation: Journal of Translational Medicine 2023 21:185
  16. Gastric cancer (GC) is a major cancer burden throughout the world with a high mortality rate. The performance of current predictive and prognostic factors is still limited. Integrated analysis is required for ...

    Authors: Wenying Yan, Yuqi Chen, Guang Hu, Tongguo Shi, Xingyi Liu, Juntao Li, Linqing Sun, Fuliang Qian and Weichang Chen
    Citation: Journal of Translational Medicine 2023 21:163
  17. The United Nations recently made a call to address the challenges of an estimated 300 million persons worldwide living with a rare disease through the collection, analysis, and dissemination of disaggregated d...

    Authors: William Z. Kariampuzha, Gioconda Alyea, Sue Qu, Jaleal Sanjak, Ewy Mathé, Eric Sid, Haley Chatelaine, Arjun Yadaw, Yanji Xu and Qian Zhu
    Citation: Journal of Translational Medicine 2023 21:157

    The Correction to this article has been published in Journal of Translational Medicine 2023 21:291

  18. Complex diseases often present as a diagnosis riddle, further complicated by the combination of multiple phenotypes and diseases as features of other diseases. With the aim of enhancing the determination of ke...

    Authors: Lynn M. Schriml, Richard Lichenstein, Katharine Bisordi, Cynthia Bearer, J. Allen Baron and Carol Greene
    Citation: Journal of Translational Medicine 2023 21:148
  19. To explore the possibility of kidney organoids generated using patient derived human induced pluripotent stem cells (hiPSC) for modeling of Fabry disease nephropathy (FDN).

    Authors: Sheng Cui, Xianying Fang, Hanbi Lee, Yoo Jin Shin, Eun-Sil Koh, Sungjin Chung, Hoon Suk Park, Sun Woo Lim, Kang In Lee, Jae Young Lee, Chul Woo Yang and Byung Ha Chung
    Citation: Journal of Translational Medicine 2023 21:138
  20. Fibroblast growth factor receptor 3 is known as a favorable aim in vast range of cancers, particularly in bladder cancer treatment. Pharmacophore and QSAR modeling approaches are broadly utilized for developin...

    Authors: Mahmoud Ganji, Shohreh Bakhshi, Alireza Shoari and Reza Ahangari Cohan
    Citation: Journal of Translational Medicine 2023 21:111
  21. Length of stay (LOS) is an important metric for evaluating the management of inpatients. This study aimed to explore the factors impacting the LOS of inpatients with type-2 diabetes mellitus (T2DM) and develop...

    Authors: Juntao Tan, Zhengyu Zhang, Yuxin He, Yue Yu, Jing Zheng, Yunyu Liu, Jun Gong, Jianjun Li, Xin Wu, Shengying Zhang, Xiantian Lin, Yuxi Zhao, Xiaoxin Wu, Songjia Tang, Jingjing Chen and Wenlong Zhao
    Citation: Journal of Translational Medicine 2023 21:91
  22. Identifying candidates responsive to treatment is important in lupus nephritis (LN) at the renal flare (RF) because an effective treatment can lower the risk of progression to end-stage kidney disease. However...

    Authors: Ding-Jie Lee, Ping-Huang Tsai, Chien-Chou Chen and Yang-Hong Dai
    Citation: Journal of Translational Medicine 2023 21:76
  23. Drug-target interaction (DTI) prediction has become a crucial prerequisite in drug design and drug discovery. However, the traditional biological experiment is time-consuming and expensive, as there are abunda...

    Authors: Zhong-Hao Ren, Zhu-Hong You, Quan Zou, Chang-Qing Yu, Yan-Fang Ma, Yong-Jian Guan, Hai-Ru You, Xin-Fei Wang and Jie Pan
    Citation: Journal of Translational Medicine 2023 21:48
  24. Accurate pathological diagnosis of invasion depth and histologic grade is key for clinical management in patients with bladder cancer (BCa), but it is labour-intensive, experience-dependent and subject to inte...

    Authors: Jiexin Pan, Guibin Hong, Hong Zeng, Chengxiao Liao, Huarun Li, Yuhui Yao, Qinghua Gan, Yun Wang, Shaoxu Wu and Tianxin Lin
    Citation: Journal of Translational Medicine 2023 21:42
  25. Recent studies have identified DNA replication stress as an important feature of advanced prostate cancer (PCa). The identification of biomarkers for DNA replication stress could therefore facilitate risk stra...

    Authors: Rong-Hua Huang, Ying-Kai Hong, Heng Du, Wei-Qi Ke, Bing-Biao Lin and Ya-Lan Li
    Citation: Journal of Translational Medicine 2023 21:20
  26. In drug development, few molecules from a large pool of early candidates become successful medicines after demonstrating a favourable benefit-risk ratio. Many decisions are made along the way to continue or st...

    Authors: Chao Chen, Xuan Zhou, Silvia Maria Lavezzi, Usman Arshad and Raman Sharma
    Citation: Journal of Translational Medicine 2023 21:17
  27. Ophthalmic epidemiology is concerned with the prevalence, distribution and other factors relating to human eye disease. While observational studies cannot avoid confounding factors from interventions, human ey...

    Authors: Jiaxin Li, Cong Li, Yu Huang, Peng Guan, Desheng Huang, Honghua Yu, Xiaohong Yang and Lei Liu
    Citation: Journal of Translational Medicine 2022 20:621
  28. Bloodstream infection (BSI) is a significant cause of mortality among patients with fever of unknown origin (FUO). Inappropriate empiric antimicrobial therapy increases difficulty in BSI diagnosis and treatmen...

    Authors: Teng Xu, Shi Wu, Jingwen Li, Li Wang and Haihui Huang
    Citation: Journal of Translational Medicine 2022 20:575
  29. In observational studies, testosterone has been reported to be associated with some types of cancers. However, the direction and magnitude of the causal association between testosterone and different types of ...

    Authors: Junke Chang, Yongming Wu, Sicheng Zhou, Ye Tian, Yan Wang, Jie Tian, Wenpeng Song, Yinxian Dong, Jue Li, Ziyi Zhao and Guowei Che
    Citation: Journal of Translational Medicine 2022 20:573
  30. The coronavirus disease 2019 (COVID-19) severely hindered the timely receipt of health care for patients with cancer, especially female patients. Depression and anxiety were more pronounced in female patients ...

    Authors: Yu Min, Zheran Liu, Rendong Huang, Ruidan Li, Jing Jin, Zhigong Wei, Ling He, Yiyan Pei, Ning Li, Yongllin Su, Xiaolin Hu and Xingchen Peng
    Citation: Journal of Translational Medicine 2022 20:560
  31. Associations of drugs with diseases provide important information for expediting drug development. Due to the number of known drug-disease associations is still insufficient, and considering that inferring ass...

    Authors: Mei-Neng Wang, Xue-Jun Xie, Zhu-Hong You, De-Wu Ding and Leon Wong
    Citation: Journal of Translational Medicine 2022 20:552
  32. Gene editing has great potential in treating diseases caused by well-characterized molecular alterations. The introduction of clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associate...

    Authors: Ajaz A. Bhat, Sabah Nisar, Soumi Mukherjee, Nirmalya Saha, Nageswari Yarravarapu, Saife N. Lone, Tariq Masoodi, Ravi Chauhan, Selma Maacha, Puneet Bagga, Punita Dhawan, Ammira Al-Shabeeb Akil, Wael El-Rifai, Shahab Uddin, Ravinder Reddy, Mayank Singh…
    Citation: Journal of Translational Medicine 2022 20:534
  33. Despite a recent increase in the number of RNA-seq datasets investigating heart failure (HF), accessibility and usability remain critical issues for medical researchers. We address the need for an intuitive an...

    Authors: Thiago Britto-Borges, Annekathrin Ludt, Etienne Boileau, Enio Gjerga, Federico Marini and Christoph Dieterich
    Citation: Journal of Translational Medicine 2022 20:513
  34. The low number of patients suffering from any given rare diseases poses a difficult problem for medical research: With the exception of some specialized biobanks and disease registries, potential study partici...

    Authors: Tobias Kussel, Torben Brenner, Galina Tremper, Josef Schepers, Martin Lablans and Kay Hamacher
    Citation: Journal of Translational Medicine 2022 20:458
  35. With the development of digital pathology and the renewal of deep learning algorithm, artificial intelligence (AI) is widely applied in tumor pathology. Previous researches have demonstrated that AI-based tumo...

    Authors: Zefeng Shen, Jintao Hu, Haiyang Wu, Zeshi Chen, Weixia Wu, Junyi Lin, Zixin Xu, Jianqiu Kong and Tianxin Lin
    Citation: Journal of Translational Medicine 2022 20:409
  36. Second primary malignancy (SPM) represents the leading long-term cause of death among patients with index head and neck squamous cell carcinoma (HNSCC). We aimed to quantify the association between postoperati...

    Authors: Xiaoke Zhu, Jian Zhou, Liang Zhou, Ming Zhang, Chunli Gao and Lei Tao
    Citation: Journal of Translational Medicine 2022 20:405
  37. The immune system plays a vital role in the pathological process of ischaemic stroke. However, the exact immune-related mechanism remains unclear. The current research aimed to identify immune-related key gene...

    Authors: Peng-Fei Zheng, Lu-Zhu Chen, Peng Liu, Hong Wei Pan, Wen-Juan Fan and Zheng-Yu Liu
    Citation: Journal of Translational Medicine 2022 20:361
  38. The current study aimed to construct a novel cancer artificial intelligence survival analysis system for predicting the individual mortality risk curves for cervical carcinoma patients receiving different trea...

    Authors: Jieyi Liang, Tingshan He, Hong Li, Xueqing Guo and Zhiqiao Zhang
    Citation: Journal of Translational Medicine 2022 20:293
  39. Sepsis is a life-threatening syndrome eliciting highly heterogeneous host responses. Current prognostic evaluation methods used in clinical practice are characterized by an inadequate effectiveness in predicti...

    Authors: Fei Guo, Xishun Zhu, Zhiheng Wu, Li Zhu, Jianhua Wu and Fan Zhang
    Citation: Journal of Translational Medicine 2022 20:265
  40. Previous studies demonstrated a positive relationship between birthweight and breast cancer; however, inconsistent, sometimes even controversial, observations also emerged, and the nature of such relationship ...

    Authors: Meng Zhang, Jiahao Qiao, Shuo Zhang and Ping Zeng
    Citation: Journal of Translational Medicine 2022 20:227
  41. While ondansetron (OND) is widespread availability, the contribution of OND to improve patient outcomes among intensive care unit (ICU) patients has not been examined. This study aimed to illustrate the associ...

    Authors: Yingying Fang, Chao Xiong and Xinghe Wang
    Citation: Journal of Translational Medicine 2022 20:223
  42. Acute kidney injury (AKI) is the most common and serious complication of sepsis, accompanied by high mortality and disease burden. The early prediction of AKI is critical for timely intervention and ultimately...

    Authors: Suru Yue, Shasha Li, Xueying Huang, Jie Liu, Xuefei Hou, Yumei Zhao, Dongdong Niu, Yufeng Wang, Wenkai Tan and Jiayuan Wu
    Citation: Journal of Translational Medicine 2022 20:215
  43. Oropharyngeal dysphagia (OD) refers to any abnormality in the physiology of swallowing in the upper gastrointestinal tract, which leads to the related clinical complications, such as malnutrition, dehydration,...

    Authors: Fatemeh Rajati, Nassim Ahmadi, Zahra Al-sadat Naghibzadeh and Mohsen Kazeminia
    Citation: Journal of Translational Medicine 2022 20:175
  44. Acute kidney injury (AKI) is a major complication following cardiac surgery that substantially increases morbidity and mortality. Current diagnostic guidelines based on elevated serum creatinine and/or the pre...

    Authors: Hang Zhang, Zhongtian Wang, Yingdan Tang, Xin Chen, Dongfang You, Yaqian Wu, Min Yu, Wen Chen, Yang Zhao and Xin Chen
    Citation: Journal of Translational Medicine 2022 20:166
  45. Established prediction models of Diabetic kidney disease (DKD) are limited to the analysis of clinical research data or general population data and do not consider hospital visits. Construct a 3-year diabetic ...

    Authors: Zheyi Dong, Qian Wang, Yujing Ke, Weiguang Zhang, Quan Hong, Chao Liu, Xiaomin Liu, Jian Yang, Yue Xi, Jinlong Shi, Li Zhang, Ying Zheng, Qiang Lv, Yong Wang, Jie Wu, Xuefeng Sun…
    Citation: Journal of Translational Medicine 2022 20:143

Annual Journal Metrics

  • 2022 Citation Impact
    7.4 - 2-year Impact Factor
    6.9 - 5-year Impact Factor
    1.458 - SNIP (Source Normalized Impact per Paper)
    1.544 - SJR (SCImago Journal Rank)

    2022 Speed
    10 days submission to first editorial decision for all manuscripts (Median)
    84 days submission to accept (Median)

    2022 Usage 
    4,243,080 downloads
    32,614 Altmetric mentions