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Computational modelling and Epidemiology

Section edited by Michael N. Liebman and Sabrina Molinaro

This section aims to allow rapid communication of methods and results that utilize computational modeling and epidemiologic approaches in translational medicine. The focus will be on population-based studies that extend towards more molecular level analysis. 

Submission of studies involving methods development is encouraged where actual application and results can be shown in the healthcare and life sciences domains. Among the approaches highlighted in this section are data-mining for health impact, data modeling, health record system design, applications of epidemiologic analysis, public policy evaluation, hypothesis evaluation and testing, risk assessment in healthcare and life sciences. These articles will describe the perspective on translational medicine where the approach and results reflect the computational modeling and epidemiologic aspects of this emerging area of research.

Featured articles

Impact of lockdown on Covid-19 case fatality rate and viral mutations spread in 7 countries in Europe and North America

Research | Maria Pachetti et al

Analysis of SARS-CoV-2 RNA-dependent RNA polymerase as a potential therapeutic drug target using a computational approach

Research | Syed Ovais Aftab et al


The effects of statins on dental and oral health: a review of preclinical and clinical studies

Review | Shabnam Tahamtan et al

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  1. Although chronic inflammation, oxidative stress, airway remodeling, and protease-antiprotease imbalance have been implicated in chronic obstructive pulmonary disease (COPD), the exact pathogenesis is still obs...

    Authors: Beibei Li, Jiajun Zhang, Hui Dong, Xueyan Feng, Liang Yu, Jinyuan Zhu and Jin Zhang
    Citation: Journal of Translational Medicine 2023 21:790
    Content type: Research Published on:

  2. Early prevention of Alzheimer’s disease (AD) is a feasible way to delay AD onset and progression. Information on AD prediction at the individual patient level will be useful in AD prevention. In this study, we...

    Authors: Xiao-He Hou, John Suckling, Xue-Ning Shen, Yong Liu, Chuan-Tao Zuo, Yu-Yuan Huang, Hong-Qi Li, Hui-Fu Wang, Chen-Chen Tan, Mei Cui, Qiang Dong, Lan Tan and Jin-Tai Yu
    Citation: Journal of Translational Medicine 2023 21:768
    Content type: Research Published on:

  3. The unfolding protein response is a critical biological process implicated in a variety of physiological functions and disease states across eukaryotes. Despite its significance, the role and underlying mechan...

    Authors: Haiyang Yu, Xiaoyu Ji and Yang Ouyang
    Citation: Journal of Translational Medicine 2023 21:759
    Content type: Research Published on:

  4. Patients with heart failure with reduced ejection fraction (HFrEF) and central sleep apnea (CSA) are at a very high risk of fatal outcomes.

    Authors: David de Gonzalo-Calvo, Pablo Martinez-Camblor, Thalia Belmonte, Ferran Barbé, Kevin Duarte, Martin R. Cowie, Christiane E. Angermann, Andrea Korte, Isabelle Riedel, Josephine Labus, Wolfgang Koenig, Faiez Zannad, Thomas Thum and Christian Bär
    Citation: Journal of Translational Medicine 2023 21:742
    Content type: Research Published on:

  5. This paper addresses the crucial task of identifying DNA/RNA binding sites, which has implications in drug/vaccine design, protein engineering, and cancer research. Existing methods utilize complex neural netw...

    Authors: Saeedeh Akbari Rokn Abadi, SeyedehFatemeh Tabatabaei and Somayyeh Koohi
    Citation: Journal of Translational Medicine 2023 21:727
    Content type: Methodology Published on:

  6. With the development and popularization of low-dose chest CT technology, the diagnosis and survival rates of patients with early lung cancer (LC) have significantly improved. The occurrence of colorectal cance...

    Authors: Zhihan Xiao, Zichen Wang, Tongyu Zhang, Yi Liu and Mingxuan Si
    Citation: Journal of Translational Medicine 2023 21:722
    Content type: Research Published on:

  7. Epidemiological studies demonstrated that multiple amino acids (AAs) were associated with cardiovascular diseases (CVDs), but whether these associations were causal remains unclear. This study aims to investig...

    Authors: Song Hu, Zhennan Lin, Meng-Jin Hu, Jiang-Shan Tan, Ting-Ting Guo, Xin Huang and Lu Hua
    Citation: Journal of Translational Medicine 2023 21:699
    Content type: Research Published on:

  8. Laryngopharyngeal cancer (LPC) includes laryngeal and hypopharyngeal cancer, whose early diagnosis can significantly improve the prognosis and quality of life of patients. Pathological biopsy of suspicious can...

    Authors: Yun Li, Wenxin Gu, Huijun Yue, Guoqing Lei, Wenbin Guo, Yihui Wen, Haocheng Tang, Xin Luo, Wenjuan Tu, Jin Ye, Ruomei Hong, Qian Cai, Qingyu Gu, Tianrun Liu, Beiping Miao, Ruxin Wang…
    Citation: Journal of Translational Medicine 2023 21:698
    Content type: Research Published on:

  9. Two versions of Framingham’s 10-year risk score are defined for cardiovascular diseases, namely laboratory-based and office-based models. The former is mainly employed in high-income countries, but unfortunate...

    Authors: Azizallah Dehghan, Sajjad Ahmadnia Motlagh, Rozhan Khezri, Fatemeh Rezaei and Dagfinn Aune
    Citation: Journal of Translational Medicine 2023 21:687
    Content type: Research Published on:

  10. Rapid identification of high-risk polytrauma patients is crucial for early intervention and improved outcomes. This study aimed to develop and validate machine learning models for predicting 72 h mortality in ...

    Authors: Wen He, Xianghong Fu and Song Chen
    Citation: Journal of Translational Medicine 2023 21:664
    Content type: Research Published on:

  11. Intracranial aneurysms (IAs) pose a significant and intricate challenge. Elucidating the interplay between DNA methylation and IA pathogenesis is paramount to identify potential biomarkers and therapeutic inte...

    Authors: Aierpati Maimaiti, Mirzat Turhon, Aimitaji Abulaiti, Yilidanna Dilixiati, Fujunhui Zhang, Aximujiang Axieer, Kaheerman Kadeer, Yisen Zhang, Aisha Maimaitili and Xinjian Yang
    Citation: Journal of Translational Medicine 2023 21:660
    Content type: Research Published on:

  12. The interest in targeted cancer therapies has been growing rapidly. While numerous cancer biomarkers and targeted treatment strategies have been developed and employed, there are still significant limitations ...

    Authors: Feihong Ren, Qiubai Jin, Tongtong Liu, Xuelei Ren and Yongli Zhan
    Citation: Journal of Translational Medicine 2023 21:646
    Content type: Research Published on:

  13. Biological ageing is tightly linked to cardiovascular disease (CVD). We aimed to investigate the relationship between Life’s Essential 8 (LE8), a currently updated measure of cardiovascular health (CVH), and b...

    Authors: Ronghuai Zhang, Min Wu, Wei Zhang, Xuna Liu, Jie Pu, Tao Wei, Zhanfang Zhu, Zhiguo Tang, Na Wei, Bo Liu, Qianwei Cui, Junkui Wang, Fuqiang Liu and Ying Lv
    Citation: Journal of Translational Medicine 2023 21:622
    Content type: Research Published on:

  14. A significant proportion of septic patients with acute lung injury (ALI) are recognized late due to the absence of an efficient diagnostic test, leading to the postponed treatments and consequently higher mort...

    Authors: Yongxin Zheng, Jinping Wang, Zhaoyi Ling, Jiamei Zhang, Yuan Zeng, Ke Wang, Yu Zhang, Lingbo Nong, Ling Sang, Yonghao Xu, Xiaoqing Liu, Yimin Li and Yongbo Huang
    Citation: Journal of Translational Medicine 2023 21:620
    Content type: Research Published on:

  15. Assisted reproductive technologies (ART) have increased the incidence of multiple births, which can have a negative impact on maternal and offspring health. The study aimed to investigate the association betwe...

    Authors: Yi Jiang, Yuanyuan Du, Rui Su, Xuan Zhou, Lijie Wei, Jingyi Zhang, Shenglan Zhu, Huiting Zhang, Chenyun Fang, Yuting Chen, Peng Gao, Liangnan Zhang, Shaoshuai Wang, Jun Yu, Mengzhou He, Wencheng Ding…
    Citation: Journal of Translational Medicine 2023 21:608
    Content type: Research Published on:

  16. The influence of the historical cardiovascular risk status on future risk of atherosclerotic cardiovascular disease (ASCVD) is poorly understood. We aimed to investigate the association between 5-year changes ...

    Authors: Jiayi Yi, Lili Wang, Xinli Guo and Xiangpeng Ren
    Citation: Journal of Translational Medicine 2023 21:589
    Content type: Research Published on:

  19. Alzheimer’s disease (AD) and cancer are common age-related diseases, and epidemiological evidence suggests an inverse relationship between them. However, investigating the potential mechanism underlying their ...

    Authors: Zehua Dong, Mengli Xu, Xu Sun and Xiaosheng Wang
    Citation: Journal of Translational Medicine 2023 21:527
    Content type: Research Published on:

  20. In patients undergoing percutaneous coronary intervention (PCI), contrast-induced acute kidney injury (CIAKI) is a frequent complication, especially in diabetics, and is connected with severe mortality and mor...

    Authors: Mengqing Ma, Xin Wan, Yuyang Chen, Zhichao Lu, Danning Guo, Huiping Kong, Binbin Pan, Hao Zhang, Dawei Chen, Dongxu Xu, Dong Sun, Hong Lang, Changgao Zhou, Tao Li and Changchun Cao
    Citation: Journal of Translational Medicine 2023 21:517
    Content type: Research Published on:

  21. Computational models are increasingly used in high-impact decision making in science, engineering, and medicine. The National Aeronautics and Space Administration (NASA) uses computational models to perform co...

    Authors: Lillian T. Tatka, Lucian P. Smith, Joseph L. Hellerstein and Herbert M. Sauro
    Citation: Journal of Translational Medicine 2023 21:501
    Content type: Review Published on:

  22. The nuclear factor kappa B (NFκB) regulatory pathways downstream of tumor necrosis factor (TNF) play a critical role in carcinogenesis. However, the widespread influence of NFκB in cells can result in off-targ...

    Authors: Yin-Yuan Su, Yu-Ling Liu, Hsuan-Cheng Huang and Chen-Ching Lin
    Citation: Journal of Translational Medicine 2023 21:485
    Content type: Research Published on:

  24. Blood biomarkers for multiple pathways, such as inflammatory response, lipid metabolism, and hormonal regulation, have been suggested to influence the risk of mortality. However, few studies have systematicall...

    Authors: Jing Yang, Jiayi Lu, Junyan Miao, Jiacong Li, Meng Zhu, Juncheng Dai, Hongxia Ma, Guangfu Jin and Dong Hang
    Citation: Journal of Translational Medicine 2023 21:471
    Content type: Research Published on:

  25. The protective effect of a higher ideal cardiovascular health (CVH) score on cardiovascular diseases (CVDs) and mortality is well recognized. However, little is known regarding the length of favorable CVH stat...

    Authors: Qiuyue Tian, Shuohua Chen, Xiaoni Meng, Haotian Wang, Cancan Li, Deqiang Zheng, Lijuan Wu, Aitian Wang, Shouling Wu and Youxin Wang
    Citation: Journal of Translational Medicine 2023 21:469
    Content type: Research Published on:

  26. The prevalence of hyperuricemia, gout, and heart failure (HF) is on the rise, and these conditions often share similar risk factors. The present study aimed to evaluate the relationship among hyperuricemia, go...

    Authors: Yingdong Han, Yu Cao, Xinxin Han, Hong Di, Yue Yin, Juan Wu, Yun Zhang and Xuejun Zeng
    Citation: Journal of Translational Medicine 2023 21:463
    Content type: Research Published on:

  28. Non-alcoholic fatty liver disease (NAFLD) shares common risk factors with cardiovascular diseases. Effects of longitudinal trends in non-high-density lipoprotein (non-HDL) cholesterol on NAFLD development are ...

    Authors: Jun-Hyuk Lee, Jiyeon Kim, Jung Oh Kim and Yu-Jin Kwon
    Citation: Journal of Translational Medicine 2023 21:435
    Content type: Research Published on:

  29. Colonoscopy is a useful as a cancer screening test. However, in countries with limited medical resources, there are restrictions on the widespread use of endoscopy. Non-invasive screening methods to determine ...

    Authors: Kohjiro Tokutake, Aaron Morelos-Gomez, Ken-ichi Hoshi, Michio Katouda, Syogo Tejima and Morinobu Endo
    Citation: Journal of Translational Medicine 2023 21:431
    Content type: Research Published on:

  30. In the United States, rare disease (RD) is defined as a condition that affects fewer than 200,000 individuals. Collectively, RD affects an estimated 30 million Americans. A significant portion of RD has an und...

    Authors: Filippo Pinto e Vairo, Jennifer L. Kemppainen, Carolyn R. Rohrer Vitek, Denise A. Whalen, Kayla J. Kolbert, Kaitlin J. Sikkink, Sarah A. Kroc, Teresa Kruisselbrink, Gabrielle F. Shupe, Alyssa K. Knudson, Elizabeth M. Burke, Elle C. Loftus, Lorelei A. Bandel, Carri A. Prochnow, Lindsay A. Mulvihill, Brittany Thomas…
    Citation: Journal of Translational Medicine 2023 21:410
    Content type: Research Published on:

    The Correction to this article has been published in Journal of Translational Medicine 2024 22:400

  31. Acute kidney injury (AKI) is a common complication in critically ill patients with sepsis and is often associated with a poor prognosis. We aimed to construct and validate an interpretable prognostic predictio...

    Authors: Zhiyan Fan, Jiamei Jiang, Chen Xiao, Youlei Chen, Quan Xia, Juan Wang, Mengjuan Fang, Zesheng Wu and Fanghui Chen
    Citation: Journal of Translational Medicine 2023 21:406
    Content type: Research Published on:

  32. Breast cancer brain metastases (BCBM) are the most fatal, with limited survival in all breast cancer distant metastases. These patients are deemed to be incurable. Thus, survival time is their foremost concern...

    Authors: Chaofan Li, Mengjie Liu, Yinbin Zhang, Yusheng Wang, Jia Li, Shiyu Sun, Xuanyu Liu, Huizi Wu, Cong Feng, Peizhuo Yao, Yiwei Jia, Yu Zhang, Xinyu Wei, Fei Wu, Chong Du, Xixi Zhao…
    Citation: Journal of Translational Medicine 2023 21:404
    Content type: Research Published on:

  33. Autism spectrum disorder (ASD) is a neurodevelopmental disorder that is difficult to diagnose. Inflammatory bowel disease (IBD) is a common chronic digestive disease. Previous studies have shown a potential co...

    Authors: Jinyi Zhu, Haoran Meng, Li Zhang and Yan Li
    Citation: Journal of Translational Medicine 2023 21:372
    Content type: Research Published on:

  34. Novel human epidermal growth factor receptor 2 (HER2)-directed antibody–drug conjugates prompt the identification of the HER2-low subtype. However, the biological significance of HER2-low expression in breast ...

    Authors: Juan Jin, Bin Li, Jianing Cao, Ting Li, Jian Zhang, Jun Cao, Mingchuan Zhao, Leiping Wang, Biyun Wang, Zhonghua Tao and Xichun Hu
    Citation: Journal of Translational Medicine 2023 21:360
    Content type: Research Published on:

  35. Chronic kidney disease (CKD) is one of the most significant cardiovascular risk factors, playing vital roles in various cardiovascular diseases such as calcific aortic valve disease (CAVD). We aim to explore t...

    Authors: Enyi Zhu, Xiaorong Shu, Zi Xu, Yanren Peng, Yunxiu Xiang, Yu Liu, Hui Guan, Ming Zhong, Jinhong Li, Li-Zhen Zhang, Ruqiong Nie and Zhihua Zheng
    Citation: Journal of Translational Medicine 2023 21:359
    Content type: Research Published on:

  36. Osteoarthritis (OA) is one of the most prevalent musculoskeletal diseases and is the leading cause of pain and disability in the aged population. However, the underlying biological mechanism has not been fully...

    Authors: Yifei Gu, Qianmei Jin, Jinquan Hu, Xinwei Wang, Wenchao Yu, Zhanchao Wang, Chen Wang, Yang Liu, Yu Chen and Wen Yuan
    Citation: Journal of Translational Medicine 2023 21:357
    Content type: Research Published on:

  37. Carotid atherosclerosis (CAS), an important factor in the development of stroke, is a major public health concern. The aim of this study was to establish and validate machine learning (ML) models for early scr...

    Authors: Ke Yun, Tao He, Shi Zhen, Meihui Quan, Xiaotao Yang, Dongliang Man, Shuang Zhang, Wei Wang and Xiaoxu Han
    Citation: Journal of Translational Medicine 2023 21:353
    Content type: Research Published on:

  38. The current ageing trend of the world population has, in part, accounted for Alzheimer disease (AD) being a public health issue in recent times. Although some progress has been made in clarifying AD-related pa...

    Authors: Benson O. A. Botchway, Xuehong Liu, Yu Zhou and Marong Fang
    Citation: Journal of Translational Medicine 2023 21:351
    Content type: Review Published on:

  39. Clear cell renal cell carcinoma (ccRCC) is a highly invasive and metastatic subtype of kidney malignancy and is correlated with metabolic reprogramming for adaptation to the tumor microenvironment comprising i...

    Authors: Hansen Lin, Liangmin Fu, Pengju Li, Jiangquan Zhu, Quanhui Xu, Yinghan Wang, Mukhtar Adan Mumin, Xinwei Zhou, Yuhang Chen, Guannan Shu, Gaosheng Yao, Minyu Chen, Jun Lu, Lizhen Zhang, YuJun Liu, Yiqi Zhao…
    Citation: Journal of Translational Medicine 2023 21:343
    Content type: Research Published on:

  40. The Swedish Childhood Tumor Biobank (BTB) is a nonprofit national infrastructure for collecting tissue samples and genomic data from pediatric patients diagnosed with central nervous system (CNS) and other sol...

    Authors: Teresita Díaz de StÃ¥hl, Alia Shamikh, Markus Mayrhofer, Szilvester Juhos, Elisa Basmaci, Gabriela Prochazka, Maxime Garcia, Praveen Raj Somarajan, Katarzyna Zielinska-Chomej, Christopher Illies, Ingrid Øra, Peter Siesjö, Per-Erik Sandström, Jakob Stenman, Magnus Sabel, Bengt Gustavsson…
    Citation: Journal of Translational Medicine 2023 21:342
    Content type: Research Published on:

  41. It is known that measuring the triglyceride glucose (TyG) index and TyG-related parameters [triglyceride glucose-body mass index (TyG-BMI), triglyceride glucose-waist circumference (TyG-WC), and triglyceride g...

    Authors: Maobin Kuang, Ruijuan Yang, Xin Huang, Chao Wang, Guotai Sheng, Guobo Xie and Yang Zou
    Citation: Journal of Translational Medicine 2023 21:299
    Content type: Research Published on:

  44. The growing epidemic of the inflammation-related metabolic disease, type 2 diabetes mellitus, presents a challenge to improve our understanding of potential mechanisms or biomarkers to prevent or better contro...

    Authors: Nicole Noren Hooten, Nicolle A. Mode, Edward Kowalik, Victor Omoniyi, Alan B. Zonderman, Ngozi Ezike, Mark J. DiNubile, Susan L. Levinson and Michele K. Evans
    Citation: Journal of Translational Medicine 2023 21:190
    Content type: Research Published on:

  45. Circadian rhythm regulates complex physiological activities in organisms. A strong link between circadian dysfunction and cancer has been identified. However, the factors of dysregulation and functional signif...

    Authors: Yuwei Liu, Shuang Guo, Yue Sun, Caiyu Zhang, Jing Gan, Shangwei Ning and Junwei Wang
    Citation: Journal of Translational Medicine 2023 21:185
    Content type: Research Published on:

  46. Gastric cancer (GC) is a major cancer burden throughout the world with a high mortality rate. The performance of current predictive and prognostic factors is still limited. Integrated analysis is required for ...

    Authors: Wenying Yan, Yuqi Chen, Guang Hu, Tongguo Shi, Xingyi Liu, Juntao Li, Linqing Sun, Fuliang Qian and Weichang Chen
    Citation: Journal of Translational Medicine 2023 21:163
    Content type: Research Published on:

  47. The United Nations recently made a call to address the challenges of an estimated 300 million persons worldwide living with a rare disease through the collection, analysis, and dissemination of disaggregated d...

    Authors: William Z. Kariampuzha, Gioconda Alyea, Sue Qu, Jaleal Sanjak, Ewy Mathé, Eric Sid, Haley Chatelaine, Arjun Yadaw, Yanji Xu and Qian Zhu
    Citation: Journal of Translational Medicine 2023 21:157
    Content type: Research Published on:

    The Correction to this article has been published in Journal of Translational Medicine 2023 21:291

  48. Complex diseases often present as a diagnosis riddle, further complicated by the combination of multiple phenotypes and diseases as features of other diseases. With the aim of enhancing the determination of ke...

    Authors: Lynn M. Schriml, Richard Lichenstein, Katharine Bisordi, Cynthia Bearer, J. Allen Baron and Carol Greene
    Citation: Journal of Translational Medicine 2023 21:148
    Content type: Research Published on:

  49. To explore the possibility of kidney organoids generated using patient derived human induced pluripotent stem cells (hiPSC) for modeling of Fabry disease nephropathy (FDN).

    Authors: Sheng Cui, Xianying Fang, Hanbi Lee, Yoo Jin Shin, Eun-Sil Koh, Sungjin Chung, Hoon Suk Park, Sun Woo Lim, Kang In Lee, Jae Young Lee, Chul Woo Yang and Byung Ha Chung
    Citation: Journal of Translational Medicine 2023 21:138
    Content type: Research Published on:

  50. Fibroblast growth factor receptor 3 is known as a favorable aim in vast range of cancers, particularly in bladder cancer treatment. Pharmacophore and QSAR modeling approaches are broadly utilized for developin...

    Authors: Mahmoud Ganji, Shohreh Bakhshi, Alireza Shoari and Reza Ahangari Cohan
    Citation: Journal of Translational Medicine 2023 21:111
    Content type: Research Published on:
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