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Cancer microenvironment

Section edited by Davide Bedognetti

The Cancer microenvironment section publishes research on the cellular and molecular components of the cancer microenvironment, with a particular focus on translational research that has important implications for the prevention, diagnosis and treatment of human neoplasms.

Submissions that relate to the characterisation of the molecular profile and regulation of cancers at different tumour stages are especially welcome, as are those which identify specific cancer microenvironments that predict tumour incidence, response to therapy and outcome. Laboratory studies of new drugs and biological agents that target cancer microenvironments will also be considered.

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  1. Content type: Research

    Acquired radioresistance during radiotherapy is considered as the most important reason for local tumor recurrence or treatment failure. Circular RNAs (circRNAs) have recently been identified as microRNA spong...

    Authors: Huafang Su, Fuqiang Lin, Xia Deng, Lanxiao Shen, Ya Fang, Zhenghua Fei, Lihao Zhao, Xuebang Zhang, Huanle Pan, Deyao Xie, Xiance Jin and Congying Xie

    Citation: Journal of Translational Medicine 2016 14:225

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  2. Content type: Research

    Immune regulation is crucial for the pathogenesis of B-cell acute lymphoblastic leukemia (B-ALL). It has been reported that Th17 cells as a newly identified subset of CD4+ T cells are involved in the pathogenesis...

    Authors: Laixi Bi, Junqing Wu, Aifang Ye, Jianbo Wu, Kang Yu, Shenghui Zhang and Yixiang Han

    Citation: Journal of Translational Medicine 2016 14:132

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  3. Content type: Research

    Angiogenesis inhibition is a promising approach for treating metastatic colorectal cancer (mCRC). Recent evidences support the seemingly counterintuitive ability of certain antiangiogenic drugs to promote norm...

    Authors: V. Leuci, F. Maione, R. Rotolo, E. Giraudo, F. Sassi, G. Migliardi, M. Todorovic, L. Gammaitoni, G. Mesiano, L. Giraudo, P. Luraghi, F. Leone, F. Bussolino, G. Grignani, M. Aglietta, L. Trusolino…

    Citation: Journal of Translational Medicine 2016 14:119

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  4. Content type: Research

    Hepatitis B virus (HBV) X protein (HBx) is a type of oncogenic protein involved in the progression of hepatocellular carcinoma (HCC) via interacting with host genes. Dysregulation of microRNAs (miRNAs) has bee...

    Authors: Guifang Yu, Xuezhu Chen, Shudi Chen, Weipeng Ye, Kailian Hou and Min Liang

    Citation: Journal of Translational Medicine 2016 14:122

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  5. Content type: Research

    TLR4/MD-2 complex-mediated MyD88-dependent activation of NF-κB and Akt promotes tumor-associated immunosuppression in epithelial ovarian cancer (EOC) via induction of immunesuppressive cytokines and indoleamin...

    Authors: Hong Liu, Guonan Zhang, Jianming Huang, Shiqi Ma, Kun Mi, Jia Cheng, Yi Zhu, Xiao Zha and Wei Huang

    Citation: Journal of Translational Medicine 2016 14:104

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  6. Content type: Review

    Changes in the tumor microenvironment and immune surveillance represent crucial hallmarks of various kinds of cancer, including oral squamous cell carcinoma (OSCC), and a close crosstalk of hypoxia regulating ...

    Authors: Alexander W. Eckert, Claudia Wickenhauser, Paul C. Salins, Matthias Kappler, Juergen Bukur and Barbara Seliger

    Citation: Journal of Translational Medicine 2016 14:85

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    The Correction to this article has been published in Journal of Translational Medicine 2018 16:40

  7. Content type: Research

    Growing evidence is showing that metastatic cell populations are able to transfer their characteristics to less malignant cells. Exosomes (EXOs) are membrane vesicles of endocytic origin able to convey their c...

    Authors: Federica Felicetti, Alessandra De Feo, Carolina Coscia, Rossella Puglisi, Francesca Pedini, Luca Pasquini, Maria Bellenghi, Maria Cristina Errico, Elena Pagani and Alessandra Carè

    Citation: Journal of Translational Medicine 2016 14:56

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  8. Content type: Research

    Aldehyde dehydrogenase 1 (ALDH1) activity has been implicated in the therapeutic drug resistance of many malignancies and has been widely used as a marker to identify stem-like cells, including in primary live...

    Authors: Prashasnika Gehlot, Vivek Shukla, Sanjay Gupta and Paul E. Makidon

    Citation: Journal of Translational Medicine 2016 14:49

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  9. Content type: Research

    Long intergenic non-coding RNAs (lncRNAs) are a class of non-coding RNAs that are involved in gene expression regulation. Taurine up-regulated gene 1 (TUG1) is a cancer progression related lncRNA in some tumor...

    Authors: Junfeng Sun, Chaohui Ding, Zhen Yang, Tao Liu, Xiefu Zhang, Chunlin Zhao and Jiaxiang Wang

    Citation: Journal of Translational Medicine 2016 14:42

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  10. Content type: Research

    The heterogeneous and dynamic tumor microenvironment has significant impact on cancer cell proliferation, invasion, drug response, and is probably associated with entering dormancy and recurrence. However, the...

    Authors: Josephine Y. Fang, Shih-Jye Tan, Yi-Chen Wu, Zhi Yang, Ba X. Hoang and Bo Han

    Citation: Journal of Translational Medicine 2016 14:38

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  11. Content type: Research

    Nitrobenzoxadiazole derivatives (NBDs), including NBDHEX and the recently developed MC3181, are promising anticancer agents able to target glutathione transferase and inhibit both its catalytic activity and a...

    Authors: Camilla Palumbo, Anastasia De Luca, Nicola Rosato, Mariantonietta Forgione, Dante Rotili and Anna Maria Caccuri

    Citation: Journal of Translational Medicine 2016 14:37

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  12. Content type: Research

    Tumour-derived microvesicles (TMVs) are important players in tumour progression, modulating biological activity of immune cells e.g. lymphocytes, monocytes and macrophages. This phenomenon is particularly inte...

    Authors: Monika Baj-Krzyworzeka, Bożenna Mytar, Rafał Szatanek, Marcin Surmiak, Kazimierz Węglarczyk, Jarek Baran and Maciej Siedlar

    Citation: Journal of Translational Medicine 2016 14:36

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  13. Content type: Research

    CD24, a mucin-like membrane glycoprotein, plays a critical role in carcinogenesis, but its role in human gastric cancer and the underlying mechanism remains undefined.

    Authors: Wenjie Deng, Luo Gu, Xiaojie Li, Jianchao Zheng, Yujie Zhang, Biao Duan, Jie Cui, Jing Dong and Jun Du

    Citation: Journal of Translational Medicine 2016 14:32

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  14. Content type: Review

    Fibroblasts are known as critical stromal cells in wound healing by synthesizing extracellular matrix and collagen. A subpopulation of them is called cancer-associated fibroblasts (CAFs), because their product...

    Authors: Jiangfeng Wang, Guangyu Zhang, Jianbo Wang, Lu Wang, Xiaochen Huang and Yufeng Cheng

    Citation: Journal of Translational Medicine 2016 14:30

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  15. Content type: Research

    Tumour cells release membrane micro(nano)fragments called tumour-derived microvesicles (TMV) that are believed to play an important role in cancer progression. TMV suppress/modify antitumour response of the ho...

    Authors: Małgorzata Stec, Rafał Szatanek, Monika Baj-Krzyworzeka, Jarosław Baran, Maria Zembala, Jakub Barbasz, Agnieszka Waligórska, Jurek W. Dobrucki, Bożenna Mytar, Antoni Szczepanik, Maciej Siedlar, Grażyna Drabik, Barbara Urbanowicz and Marek Zembala

    Citation: Journal of Translational Medicine 2015 13:376

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  16. Content type: Research

    This study aimed to investigate whether the DNA methylation of human ovarian carcinoma stromal progenitor cells (OCSPCs) could promote the tumorigenesis of ovarian carcinoma.

    Authors: Chih-Ming Ho, Daniel Tzu-bi Shih, Chih-Chiang Hsiao, Shih-Hung Huang, Shwu-Fen Chang and Wen-Fang Cheng

    Citation: Journal of Translational Medicine 2015 13:367

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  17. Content type: Research

    Fei-Liu-Ping (FLP) ointment is an oral prescription medication that has been widely applied to treat lung cancer patients in China. Regulation of the metastatic microenvironment is an important therapeutic app...

    Authors: Rui Liu, Honggang Zheng, Weidong Li, Qiujun Guo, Shulin He, Yoshiro Hirasaki, Wei Hou, Baojin Hua, Conghuang Li, Yanju Bao, Yebo Gao, Xin Qi, Yingxia Pei and Yun Zhang

    Citation: Journal of Translational Medicine 2015 13:366

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  18. Content type: Research

    Chemokines have been recognized as important modulators of angiogenesis, and they play critical roles in the development and metastasis of hepatocellular carcinoma (HCC), although their origins and latent mole...

    Authors: Bing Zhu, Nan Lin, Min Zhang, Yong Zhu, Huanhuan Cheng, Shuxian Chen, Yunbiao Ling, Weidong Pan and Ruiyun Xu

    Citation: Journal of Translational Medicine 2015 13:365

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  19. Content type: Research

    To evaluate the influence of the progonistic nutritional index (PNI) and weight loss on metastasis and long-term mortality in nasopharyngeal carcinoma (NPC).

    Authors: Xiao-Jing Du, Ling-Long Tang, Yan-Ping Mao, Rui Guo, Ying Sun, Ai-Hua Lin and Jun Ma

    Citation: Journal of Translational Medicine 2015 13:364

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  20. Content type: Research

    Glioblastoma is the most common and lethal type of primary brain tumor. β-Elemene, a natural plant drug extracted from Curcuma wenyujin, has shown strong anti-tumor effects in various tumors with low toxicity. Ho...

    Authors: Tingzhun Zhu, Xiaoming Li, Lihan Luo, Xiaogang Wang, Zhiqing Li, Peng Xie, Xu Gao, Zhenquan Song, Jingyuan Su and Guobiao Liang

    Citation: Journal of Translational Medicine 2015 13:356

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  21. Content type: Research

    Heat shock factor 1 (HSF1) is a powerful, multifaceted modifier of carcinogenesis. However, the clinical significance and biologic function of HSF1 in esophageal squamous cell carcinoma (ESCC) remain unknown.

    Authors: Yuehua Liao, Ying Xue, Lin Zhang, Xinwei Feng, Wanli Liu and Ge Zhang

    Citation: Journal of Translational Medicine 2015 13:338

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  22. Content type: Research

    This study aimed to investigate the expression of CD147 and MMP-11 in human colorectal cancer (CRC) and to evaluate their clinical significance.

    Authors: Xiuyun Tian, Chunxiang Ye, Yongyong Yang, Xiaoya Guan, Bin Dong, Min Zhao and Chunyi Hao

    Citation: Journal of Translational Medicine 2015 13:337

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  23. Content type: Research

    Cisplatin is the main chemotherapeutic drug for the treatment of cervical cancers, however resistance to cisplatin is increasingly common and therefore has limited the efficacy and use of this drug in the clin...

    Authors: Gina Leisching, Benjamin Loos, Matthys Botha and Anna-Mart Engelbrecht

    Citation: Journal of Translational Medicine 2015 13:328

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  24. Content type: Research

    Malignant pleural effusion resulting mainly from pleural metastases of lung adenocarcinoma has clinical relevance, being a sign of poor prognosis and low life expectancy. Experimental models can mimic the hum...

    Authors: Milena Marques Pagliarelli Acencio, Juliana Puka, Evaldo Marchi, Leila Antonangelo, Ricardo Mingarini Terra, Francisco Suso Vargas, Vera Luiza Capelozzi and Lisete Ribeiro Teixeira

    Citation: Journal of Translational Medicine 2015 13:302

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  25. Content type: Research

    An increasing number of studies have demonstrated that deregulation of microRNAs (miRNAs) was a common event in tumor tissues and miRNAs would be treated as ideal tumor biomarkers or therapeutic targets. miR-1...

    Authors: Jian Wu, Alin Ji, Xiao Wang, Yi Zhu, Yasai Yu, Yiwei Lin, Yunfu Liu, Shiqi Li, Zhen Liang, Xin Xu, Xiangyi Zheng and Liping Xie

    Citation: Journal of Translational Medicine 2015 13:289

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  26. Content type: Research

    Hepatocyte growth factor (HGF) is a cytokine that has a profound effect on cancer cells by stimulating migration and invasion and acting as an angiogenic factor. In lung cancer, the factor also plays a pivota...

    Authors: Wen G. Jiang, Lin Ye, Fiona Ruge, Sioned Owen, Tracey Martin, Ping-Hui Sun, Andrew J. Sanders, Jane Lane, Lucy Satherley, Hoi P. Weeks, Yong Gao, Cong Wei, Yiling Wu and Malcolm D. Mason

    Citation: Journal of Translational Medicine 2015 13:280

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  27. Content type: Research

    Various microRNAs (miRNAs) negatively modulate genes that are involved in cellular proliferation, differentiation, invasion, and apoptosis. In many types of cancer, the expression profiles of these miRNAs are ...

    Authors: MingHua Li, LinLi Tian, Hui Ren, XiaoXue Chen, Yu Wang, JingChun Ge, ShuLiang Wu, YaNan Sun, Ming Liu and Hui Xiao

    Citation: Journal of Translational Medicine 2015 13:271

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  28. Content type: Research

    Liver metastases appear in 20–30% of patients diagnosed with non-small cell lung cancer (NSCLC) and represent a poor prognosis feature of NSCLC and a possibly more treatment-resistant condition. Potential clin...

    Authors: Eduardo Castañón, Christian Rolfo, David Viñal, Inés López, Juan P Fusco, Marta Santisteban, Patricia Martin, Leire Zubiri, José I Echeveste and Ignacio Gil-Bazo

    Citation: Journal of Translational Medicine 2015 13:257

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  29. Content type: Research

    Radioresistance is a challenge in the treatment of patients with colorectal cancer (CRC). Individuals display different therapeutic responses to preoperative radiotherapy, and the need of targeted therapies is...

    Authors: Lin Zheng, Yuqin Zhang, Yan Liu, Min Zhou, Yanxia Lu, Li Yuan, Chao Zhang, Min Hong, Shuang Wang and Xuenong Li

    Citation: Journal of Translational Medicine 2015 13:252

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  30. Content type: Research

    Carcinoma associated fibroblasts (CAFs), an important component of tumor microenvironment, are capable of enhancing tumor cells invasion and migration through initiation of epithelial–mesenchymal transition (E...

    Authors: Songming Ding, Guoliang Chen, Wu Zhang, Chunyang Xing, Xiao Xu, Haiyang Xie, Aili Lu, Kangjie Chen, Haijun Guo, Zhigang Ren, Shusen Zheng and Lin Zhou

    Citation: Journal of Translational Medicine 2015 13:237

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  31. Content type: Research

    We and others have extensively investigated the role of PARP-1 in cell growth and demise in response to pathophysiological cues. Most of the clinical trials on PARP inhibitors are targeting primarily estrogen ...

    Authors: Hogyoung Kim, Abdelmetalab Tarhuni, Zakaria Y Abd Elmageed and A Hamid Boulares

    Citation: Journal of Translational Medicine 2015 13:233

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  32. Content type: Research

    In this era of precision medicine, the deep and comprehensive characterization of tumor phenotypes will lead to therapeutic strategies beyond classical factors such as primary sites or anatomical staging. Rece...

    Authors: Anna Halama, Bella S Guerrouahen, Jennifer Pasquier, Ilhem Diboun, Edward D Karoly, Karsten Suhre and Arash Rafii

    Citation: Journal of Translational Medicine 2015 13:223

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  33. Content type: Research

    Cancer-associated fibroblast (CAF) is the most studied element of the tumor microenvironment, although no relationship has been identified between expression of their related proteins and the metastasis site. ...

    Authors: Hye Min Kim, Woo Hee Jung and Ja Seung Koo

    Citation: Journal of Translational Medicine 2015 13:222

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  34. Content type: Research

    Oncolytic virotherapy is a novel approach for the treatment of glioblastoma multiforme (GBM) which is still a fatal disease. Pathologic features of GBM are characterized by the infiltration with microglia/macr...

    Authors: Christina Kober, Susanne Rohn, Stephanie Weibel, Ulrike Geissinger, Nanhai G Chen and Aladar A Szalay

    Citation: Journal of Translational Medicine 2015 13:216

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  35. Content type: Review

    Since the mid-1950’s, melanoma incidence has been rising steadily in industrialized Caucasian populations, thereby pointing to the pivotal involvement of environmental factors in melanomagenesis. Recent eviden...

    Authors: Bodo C Melnik

    Citation: Journal of Translational Medicine 2015 13:202

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  36. Content type: Research

    Oral tongue squamous cell carcinoma (OTSCC) is still associated with a poor prognosis due to local recurrence and metastasis. Cancer-associated fibroblasts (CAFs) play an important role in the complex processe...

    Authors: Huan Li, Ji Zhang, Shu-Wei Chen, Lu-lu Liu, Lei Li, Fan Gao, Shi-Min Zhuang, Li-ping Wang, Yan Li and Ming Song

    Citation: Journal of Translational Medicine 2015 13:198

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  37. Content type: Review

    Adrenomedullin (AM) is a regulatory peptide whose involvement in tumour progression is becoming more relevant with recent studies. AM is produced and secreted by the tumour cells but also by numerous stromal c...

    Authors: Ignacio M Larráyoz, Sonia Martínez-Herrero, Josune García-Sanmartín, Laura Ochoa-Callejero and Alfredo Martínez

    Citation: Journal of Translational Medicine 2014 12:339

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  38. Content type: Review

    Ovarian cancer is the deadliest gynaecologic malignancy. Despite progresses in chemotherapy and ultra-radical surgeries, this locally metastatic disease presents a high rate of local recurrence advocating for ...

    Authors: Cyril Touboul, Fabien Vidal, Jennifer Pasquier, Raphael Lis and Arash Rafii

    Citation: Journal of Translational Medicine 2014 12:271

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  39. Content type: Research

    We previously confirmed that propofol directly inhibited the viability, proliferation, and invasiveness of hepatocellular carcinoma cells in vitro. In this study, we investigated the mechanism underlying the anti...

    Authors: Jian Zhang, Wei-feng Shan, Te-te Jin, Guo-qing Wu, Xiao-xing Xiong, Hai-yan Jin and Sheng-mei Zhu

    Citation: Journal of Translational Medicine 2014 12:279

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  40. Content type: Research

    Human papillomavirus type-16 (HPV-16) E2 protein acts as a transcriptional modulator and plays a key role in regulating many biological responses. The purpose of this study was to investigate the relationship ...

    Authors: Zheng-lin Chen, Ya-juan Su, Hui-lin Zhang, Ping-qing Gu and Ling-juan Gao

    Citation: Journal of Translational Medicine 2014 12:286

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  41. Content type: Research

    Aberrant AKT activation contributes to gastric cancer cell survival and chemotherapy resistance, however its regulation is poorly understood. microRNAs have been established to be important regulators in gastr...

    Authors: Wei Kang, Joanna HM Tong, Raymond WM Lung, Yujuan Dong, Weiqin Yang, Yi Pan, Kin Mang Lau, Jun Yu, Alfred SL Cheng and Ka Fai To

    Citation: Journal of Translational Medicine 2014 12:281

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  42. Content type: Research

    Although several studies suggest that stromal fibroblasts mediate treatment resistance in several cancer types, little is known about how tumor-associated astrocytes modulate the treatment response in brain tu...

    Authors: Ning Yang, Tao Yan, Huaiyang Zhu, Xiao Liang, Lina Leiss, Per Øystein Sakariassen, Kai Ove Skaftnesmo, Bin Huang, Daniela Elena Costea, Per Øyvind Enger, Xingang Li and Jian Wang

    Citation: Journal of Translational Medicine 2014 12:278

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  43. Content type: Research

    Galectin-3, a member of the beta-galactoside-binding lectin family, is a multifunctional protein with various biological functions, including the proliferation and differentiation of tumor cells, angiogenesis,...

    Authors: Shan-Shan Jiang, De-Sheng Weng, Qi-Jing Wang, Ke Pan, Yao-Jun Zhang, Yong-Qiang Li, Jian-Jun Li, Jing-Jing Zhao, Jia He, Lin Lv, Qiu-Zhong Pan and Jian-Chuan Xia

    Citation: Journal of Translational Medicine 2014 12:273

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  44. Content type: Research

    The omentum is one of the initial sites for peritoneal metastasis because it possesses milky spots that provide a microenvironment for cancer cells to readily migrate and grow into micrometastases. This study ...

    Authors: Liang Cao, Xiang Hu, Jian Zhang, Gang Huang and Yi Zhang

    Citation: Journal of Translational Medicine 2014 12:267

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  45. Content type: Research

    EGFR-targeted therapy is an attractive option for head and neck squamous cell carcinoma patients. We have recently reported the use of EGFR inhibitors as an adjunct treatment to enhance HLA-DR expression in tu...

    Authors: Takumi Kumai, Kensuke Oikawa, Naoko Aoki, Shoji Kimura, Yasuaki Harabuchi, Esteban Celis and Hiroya Kobayashi

    Citation: Journal of Translational Medicine 2014 12:265

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  46. Content type: Research

    Recently, miR-10b is identified as a miRNA highly expressed in many human cancers, promoting cell migration and invasion. However, the specific function of miR-10b in hepatocellular carcinoma (HCC) is unclear ...

    Authors: Cheng-gong Liao, Ling-min Kong, Ping Zhou, Xiu-li Yang, Jian-guo Huang, He-long Zhang and Ning Lu

    Citation: Journal of Translational Medicine 2014 12:234

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  47. Content type: Research

    Angiogenesis plays a pivotal role in malignant tumour growth and the metastatic process. We analysed the prognostic value of two angiogenesis parameters, microRNA-126 (miRNA-126) and microvessel density (MVD),...

    Authors: Torben Frøstrup Hansen, Sanne Kjær-Frifeldt, Søren Morgenthaler, Thorarinn Blondal, Jan Lindebjerg, Anders Jakobsen and Flemming Brandt Sørensen

    Citation: Journal of Translational Medicine 2014 12:254

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  48. Content type: Research

    The treatment of oral squamous cell carcinoma (OSCC) following early detection is associated with good outcomes. Therefore, the survival and prognosis of OSCC patients could be hugely improved by identifying r...

    Authors: Yi-Hui Lai, Ru-Yin He, Jian-Liang Chou, Michael W-Y Chan, Yu-Fen Li and Chien-Kuo Tai

    Citation: Journal of Translational Medicine 2014 12:237

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  49. Content type: Research

    Expression of the long non-coding RNA (lncRNA) LOC285194 was previously shown to be correlated with aggressive clinicopathological features and poor prognosis in several cancers. The aim of the present study w...

    Authors: Yu-suo Tong, Xi-lei Zhou, Xiao-wei Wang, Qing-quan Wu, Tong-xin Yang, Jin Lv, Jin-song Yang, Bin Zhu and Xiu-feng Cao

    Citation: Journal of Translational Medicine 2014 12:233

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