Cancer microenvironment

Section edited by Davide Bedognetti

The Cancer microenvironment section publishes research on the cellular and molecular components of the cancer microenvironment, with a particular focus on translational research that has important implications for the prevention, diagnosis and treatment of human neoplasms.

Submissions that relate to the characterisation of the molecular profile and regulation of cancers at different tumour stages are especially welcome, as are those which identify specific cancer microenvironments that predict tumour incidence, response to therapy and outcome. Laboratory studies of new drugs and biological agents that target cancer microenvironments will also be considered.

Previous Page Page 2 of 9 Next Page
  1. Research

    Lenalidomide normalizes tumor vessels in colorectal cancer improving chemotherapy activity

    Angiogenesis inhibition is a promising approach for treating metastatic colorectal cancer (mCRC). Recent evidences support the seemingly counterintuitive ability of certain antiangiogenic drugs to promote norm...

    V. Leuci, F. Maione, R. Rotolo, E. Giraudo, F. Sassi, G. Migliardi, M. Todorovic, L. Gammaitoni, G. Mesiano, L. Giraudo, P. Luraghi, F. Leone, F. Bussolino, G. Grignani, M. Aglietta, L. Trusolino…

    Journal of Translational Medicine 2016 14:119

    Published on: 5 May 2016

  2. Research

    Atractylenolide I modulates ovarian cancer cell-mediated immunosuppression by blocking MD-2/TLR4 complex-mediated MyD88/NF-κB signaling in vitro

    TLR4/MD-2 complex-mediated MyD88-dependent activation of NF-κB and Akt promotes tumor-associated immunosuppression in epithelial ovarian cancer (EOC) via induction of immunesuppressive cytokines and indoleamin...

    Hong Liu, Guonan Zhang, Jianming Huang, Shiqi Ma, Kun Mi, Jia Cheng, Yi Zhu, Xiao Zha and Wei Huang

    Journal of Translational Medicine 2016 14:104

    Published on: 27 April 2016

  3. Review

    Clinical relevance of the tumor microenvironment and immune escape of oral squamous cell carcinoma

    Changes in the tumor microenvironment and immune surveillance represent crucial hallmarks of various kinds of cancer, including oral squamous cell carcinoma (OSCC), and a close crosstalk of hypoxia regulating ...

    Alexander W. Eckert, Claudia Wickenhauser, Paul C. Salins, Matthias Kappler, Juergen Bukur and Barbara Seliger

    Journal of Translational Medicine 2016 14:85

    Published on: 5 April 2016

  4. Research

    Exosome-mediated transfer of miR-222 is sufficient to increase tumor malignancy in melanoma

    Growing evidence is showing that metastatic cell populations are able to transfer their characteristics to less malignant cells. Exosomes (EXOs) are membrane vesicles of endocytic origin able to convey their c...

    Federica Felicetti, Alessandra De Feo, Carolina Coscia, Rossella Puglisi, Francesca Pedini, Luca Pasquini, Maria Bellenghi, Maria Cristina Errico, Elena Pagani and Alessandra Carè

    Journal of Translational Medicine 2016 14:56

    Published on: 24 February 2016

  5. Research

    The long non-coding RNA TUG1 indicates a poor prognosis for colorectal cancer and promotes metastasis by affecting epithelial-mesenchymal transition

    Long intergenic non-coding RNAs (lncRNAs) are a class of non-coding RNAs that are involved in gene expression regulation. Taurine up-regulated gene 1 (TUG1) is a cancer progression related lncRNA in some tumor...

    Junfeng Sun, Chaohui Ding, Zhen Yang, Tao Liu, Xiefu Zhang, Chunlin Zhao and Jiaxiang Wang

    Journal of Translational Medicine 2016 14:42

    Published on: 8 February 2016

  6. Research

    c-Jun N-terminal kinase activation by nitrobenzoxadiazoles leads to late-stage autophagy inhibition

    Nitrobenzoxadiazole derivatives (NBDs), including NBDHEX and the recently developed MC3181, are promising anticancer agents able to target glutathione transferase and inhibit both its catalytic activity and a...

    Camilla Palumbo, Anastasia De Luca, Nicola Rosato, Mariantonietta Forgione, Dante Rotili and Anna Maria Caccuri

    Journal of Translational Medicine 2016 14:37

    Published on: 4 February 2016

  7. Research

    Colorectal cancer-derived microvesicles modulate differentiation of human monocytes to macrophages

    Tumour-derived microvesicles (TMVs) are important players in tumour progression, modulating biological activity of immune cells e.g. lymphocytes, monocytes and macrophages. This phenomenon is particularly inte...

    Monika Baj-Krzyworzeka, Bożenna Mytar, Rafał Szatanek, Marcin Surmiak, Kazimierz Węglarczyk, Jarek Baran and Maciej Siedlar

    Journal of Translational Medicine 2016 14:36

    Published on: 2 February 2016

  8. Review

    The role of cancer-associated fibroblasts in esophageal cancer

    Fibroblasts are known as critical stromal cells in wound healing by synthesizing extracellular matrix and collagen. A subpopulation of them is called cancer-associated fibroblasts (CAFs), because their product...

    Jiangfeng Wang, Guangyu Zhang, Jianbo Wang, Lu Wang, Xiaochen Huang and Yufeng Cheng

    Journal of Translational Medicine 2016 14:30

    Published on: 29 January 2016

  9. Research

    Interactions of tumour-derived micro(nano)vesicles with human gastric cancer cells

    Tumour cells release membrane micro(nano)fragments called tumour-derived microvesicles (TMV) that are believed to play an important role in cancer progression. TMV suppress/modify antitumour response of the ho...

    Małgorzata Stec, Rafał Szatanek, Monika Baj-Krzyworzeka, Jarosław Baran, Maria Zembala, Jakub Barbasz, Agnieszka Waligórska, Jurek W. Dobrucki, Bożenna Mytar, Antoni Szczepanik, Maciej Siedlar, Grażyna Drabik, Barbara Urbanowicz and Marek Zembala

    Journal of Translational Medicine 2015 13:376

    Published on: 1 December 2015

  10. Research

    Anti-tumor enhancement of Fei-Liu-Ping ointment in combination with celecoxib via cyclooxygenase-2-mediated lung metastatic inflammatory microenvironment in Lewis lung carcinoma xenograft mouse model

    Fei-Liu-Ping (FLP) ointment is an oral prescription medication that has been widely applied to treat lung cancer patients in China. Regulation of the metastatic microenvironment is an important therapeutic app...

    Rui Liu, Honggang Zheng, Weidong Li, Qiujun Guo, Shulin He, Yoshiro Hirasaki, Wei Hou, Baojin Hua, Conghuang Li, Yanju Bao, Yebo Gao, Xin Qi, Yingxia Pei and Yun Zhang

    Journal of Translational Medicine 2015 13:366

    Published on: 23 November 2015

  11. Research

    Activated hepatic stellate cells promote angiogenesis via interleukin-8 in hepatocellular carcinoma

    Chemokines have been recognized as important modulators of angiogenesis, and they play critical roles in the development and metastasis of hepatocellular carcinoma (HCC), although their origins and latent mole...

    Bing Zhu, Nan Lin, Min Zhang, Yong Zhu, Huanhuan Cheng, Shuxian Chen, Yunbiao Ling, Weidong Pan and Ruiyun Xu

    Journal of Translational Medicine 2015 13:365

    Published on: 22 November 2015

  12. Research

    Reversion of malignant phenotypes of human glioblastoma cells by β-elemene through β-catenin-mediated regulation of stemness-, differentiation- and epithelial-to-mesenchymal transition-related molecules

    Glioblastoma is the most common and lethal type of primary brain tumor. β-Elemene, a natural plant drug extracted from Curcuma wenyujin, has shown strong anti-tumor effects in various tumors with low toxicity. Ho...

    Tingzhun Zhu, Xiaoming Li, Lihan Luo, Xiaogang Wang, Zhiqing Li, Peng Xie, Xu Gao, Zhenquan Song, Jingyuan Su and Guobiao Liang

    Journal of Translational Medicine 2015 13:356

    Published on: 12 November 2015

  13. Research

    Higher heat shock factor 1 expression in tumor stroma predicts poor prognosis in esophageal squamous cell carcinoma patients

    Heat shock factor 1 (HSF1) is a powerful, multifaceted modifier of carcinogenesis. However, the clinical significance and biologic function of HSF1 in esophageal squamous cell carcinoma (ESCC) remain unknown.

    Yuehua Liao, Ying Xue, Lin Zhang, Xinwei Feng, Wanli Liu and Ge Zhang

    Journal of Translational Medicine 2015 13:338

    Published on: 28 October 2015

Previous Page Page 2 of 9 Next Page