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Cancer microenvironment

Section edited by Davide Bedognetti

The Cancer microenvironment section publishes research on the cellular and molecular components of the cancer microenvironment, with a particular focus on translational research that has important implications for the prevention, diagnosis and treatment of human neoplasms.

Submissions that relate to the characterisation of the molecular profile and regulation of cancers at different tumour stages are especially welcome, as are those which identify specific cancer microenvironments that predict tumour incidence, response to therapy and outcome. Laboratory studies of new drugs and biological agents that target cancer microenvironments will also be considered.

Featured articles

Anovel non-hodgkin lymphoma murine model closer to the standard clinical scenario A novel non-Hodgkin lymphoma murine model closer to the standard clinical scenario
Thais Bascuas, et al


Impact of agin on host immune response and survival in melanomaImpact of aging on host immune response and survival in melanoma: an analysis of 3 patient cohorts
Sarah A. Weiss, et al


Differential tumour infiltration by T-Cells characterises intrinsic molecular subtypes in breast cancerDifferential tumor infiltration by T-cells characterizes intrinsic molecular subtypes in breast cancer
M. Miyan, J, et al

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  1. The aim of this study was to investigate the expression of the nuclear receptor PPARγ, together with that of the cyclooxygenases Cox-1 and Cox-2, in breast cancer (BC) tissues and to correlate the data with se...

    Authors: Wanting Shao, Christina Kuhn, Doris Mayr, Nina Ditsch, Magdalena Kailuwait, Verena Wolf, Nadia Harbeck, Sven Mahner, Udo Jeschke, Vincent Cavaillès and Sophie Sixou

    Citation: Journal of Translational Medicine 2020 18:94

    Content type: Research

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  2. Metabolic reprogramming, immune evasion and tumor-promoting inflammation are three hallmarks of cancer that provide new perspectives for understanding the biology of cancer. We aimed to figure out the relation...

    Authors: Wenhui Li, Ming Xu, Yu Li, Ziwei Huang, Jun Zhou, Qiuyang Zhao, Kehao Le, Fang Dong, Cheng Wan and Pengfei Yi

    Citation: Journal of Translational Medicine 2020 18:92

    Content type: Research

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  3. The p.E318K variant of the Melanocyte Inducing Transcription Factor (MITF) has been implicated in genetic predisposition to melanoma as an intermediate penetrance allele. However, the impact of this variant on cl...

    Authors: Giulia Ciccarese, Bruna Dalmasso, William Bruno, Paola Queirolo, Lorenza Pastorino, Virginia Andreotti, Francesco Spagnolo, Enrica Tanda, Giovanni Ponti, Cesare Massone, Francesco Drago, Aurora Parodi, Giovanni Ghigliotti, Maria Antonietta Pizzichetta and Paola Ghiorzo

    Citation: Journal of Translational Medicine 2020 18:78

    Content type: Research

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  4. Pancreatic cancer is a major cause of cancer-related mortality. The identification of effective biomarkers is essential in order to improve management of the disease. Yes-associated protein 1 (YAP1) is a downs...

    Authors: Qimin Zhou, Monika Bauden, Roland Andersson, Dingyuan Hu, György Marko-Varga, Jianfeng Xu, Agata Sasor, Hua Dai, Krzysztof Pawłowski, Katarzyna Said Hilmersson, Xi Chen and Daniel Ansari

    Citation: Journal of Translational Medicine 2020 18:77

    Content type: Research

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  5. With the gradual unveiling of tumour heterogeneity, cancer stem cells (CSCs) are now being considered the initial component of tumour initiation. However, the mechanisms of the growth and maintenance of breast...

    Authors: Jianying Pei, Yanxia Wang and Yan Li

    Citation: Journal of Translational Medicine 2020 18:74

    Content type: Research

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  6. Translationally controlled tumor protein (TCTP) is linked to lung cancer. However, upon lung cancer carcinogens stimulation, there were no reports on the relationship between TCTP and lung cell carcinogenic ep...

    Authors: Li-Zhong Liu, Menghuan Wang, Qihang Xin, Bowen Wang, George G. Chen and Ming-Yue Li

    Citation: Journal of Translational Medicine 2020 18:66

    Content type: Research

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  7. Cancer recurrence is the important problem of cholangiocarcinoma (CCA) patients, lead to a very high mortality rate. Therefore, the identification of candidate markers to predict CCA recurrence is needed in or...

    Authors: Sureerat Padthaisong, Malinee Thanee, Nisana Namwat, Jutarop Phetcharaburanin, Poramate Klanrit, Narong Khuntikeo, Attapol Titapun, Sakkarn Sungkhamanon, Hideyuki Saya and Watcharin Loilome

    Citation: Journal of Translational Medicine 2020 18:64

    Content type: Research

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  8. Accumulating evidence suggests that plasminogen activator inhibitor-1 (PAI-1) plays an important role in bladder tumorigenesis by regulating cell cycle. However, it remains unclear whether and how inhibition o...

    Authors: Hideki Furuya, Kazukuni Hayashi, Yoshiko Shimizu, Nari Kim, Yutaro Tsukikawa, Runpu Chen, Yijun Sun, Owen T. M. Chan, Ian Pagano, Rafael Peres, Kanani Hokutan, Fumie Igari, Keith S. Chan and Charles J. Rosser

    Citation: Journal of Translational Medicine 2020 18:57

    Content type: Research

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  9. Interaction between malignant cells and immune cells that reside within the tumor microenvironment (TME) modulate different aspects of tumor development and progression. Recent works showed the importance of m...

    Authors: Natasha A. N. Jorge, Jéssica G. V. Cruz, Marco Antônio M. Pretti, Martín H. Bonamino, Patricia A. Possik and Mariana Boroni

    Citation: Journal of Translational Medicine 2020 18:56

    Content type: Research

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  10. Few data are known regarding the molecular features and patterns of growth and presentation which characterize those lung neoplastic lesions presenting as non-solid nodules (NSN).

    Authors: Chandra Bortolotto, Claudio Maglia, Antonio Ciuffreda, Manuela Coretti, Roberta Catania, Filippo Antonacci, Sergio Carnevale, Ivana Sarotto, Roberto Dore, Andrea Riccardo Filippi, Gabriele Chiara, Daniele Regge, Lorenzo Preda, Patrizia Morbini and Giulia Maria Stella

    Citation: Journal of Translational Medicine 2020 18:54

    Content type: Research

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  11. The concept of cancer as a cell-autonomous disease has been challenged by the wealth of knowledge gathered in the past decades on the importance of tumor microenvironment (TM) in cancer progression and metasta...

    Authors: Jennifer Pasquier, Pegah Ghiabi, Lotfi Chouchane, Kais Razzouk, Shahin Rafii and Arash Rafii

    Citation: Journal of Translational Medicine 2020 18:52

    Content type: Review

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  12. Zinc finger E-box binding homeobox 1 (ZEB1, also termed TCF8 and δEF1) is a crucial member of the zinc finger-homeodomain transcription factor family, originally identified as a binding protein of the lens-spe...

    Authors: Hua-Tao Wu, Hui-Ting Zhong, Guan-Wu Li, Jia-Xin Shen, Qian-Qian Ye, Man-Li Zhang and Jing Liu

    Citation: Journal of Translational Medicine 2020 18:51

    Content type: Review

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  13. Long non-coding RNAs (lncRNAs) have been reported to be prognostic biomarkers in many types of cancer. We aimed to identify a lncRNA signature that can predict the prognosis in patients with esophageal squamou...

    Authors: Nuo-Qing Weng, Jun Chi, Jing Wen, Shi-Juan Mai, Mei-Yin Zhang, Long Huang, Ji Liu, Xian-Zi Yang, Guo-Liang Xu, Jian-Hua Fu and Hui-Yun Wang

    Citation: Journal of Translational Medicine 2020 18:47

    Content type: Research

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  14. Chronic inflammation is a risk factor for head and neck squamous cell carcinoma (HNSCC) and other diseases. Prostanoid receptors are clearly involved in the development of many types of cancer. However, their ...

    Authors: Kiyoshi Misawa, Masato Mima, Yamada Satoshi, Atsushi Imai, Daiki Mochizuki, Ryuji Ishikawa, Junya Kita, Yuki Yamaguchi, Shiori Endo, Yuki Misawa and Hiroyuki Mineta

    Citation: Journal of Translational Medicine 2020 18:31

    Content type: Research

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  15. Most oral squamous cell carcinomas (OSCC) occur on the basis of oral leukoplakias (OLP). The histologic degree of dysplasia is insufficient for the prediction of OLP malignant transformation. Immunologic param...

    Authors: Manuel Weber, Falk Wehrhan, Christoph Baran, Abbas Agaimy, Maike Büttner-Herold, Hatice Öztürk, Kristina Neubauer, Claudia Wickenhauser, Marco Kesting and Jutta Ries

    Citation: Journal of Translational Medicine 2020 18:11

    Content type: Research

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  16. The present review aimed to discuss contemporary scientific literature involving differences between the tumor microenvironment (TME) in melanoma, lung cancer, and breast cancer in their primary site and TME i...

    Authors: Bernardo Cacho-Díaz, Donovan R. García-Botello, Talia Wegman-Ostrosky, Gervith Reyes-Soto, Elizabeth Ortiz-Sánchez and Luis Alonso Herrera-Montalvo

    Citation: Journal of Translational Medicine 2020 18:1

    Content type: Review

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  17. Epithelial ovarian cancer (EOC) is the most lethal cancer in female genital tumors. New disease markers and novel therapeutic strategies are urgent to identify considering the current status of treatment. Rece...

    Authors: Rui Li, Tianfeng Liu, Juanjuan Shi, Wenqing Luan, Xuan Wei, Jiangtao Yu, Hongluan Mao and Peishu Liu

    Citation: Journal of Translational Medicine 2019 17:428

    Content type: Research

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  18. Lung cancer (LC) is one of the most lethal and most prevalent malignant tumors, and its incidence and mortality are increasing annually. Lung adenocarcinoma (LUAD) is the most common pathological type of lung ...

    Authors: Lei Zhang, Zhe Zhang and Zhenglun Yu

    Citation: Journal of Translational Medicine 2019 17:423

    Content type: Research

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  19. Hepatocellular carcinoma (HCC) is the most frequent primary liver cancer associated with a high mortality. Long non-coding RNAs (lncRNAs) have recently emerged as regulators in the development and progression ...

    Authors: Weiwei Wang, Guoyong Chen, Bing Wang, Zhenhua Yuan, Guangbo Liu, Biao Niu, Yongfeng Chen, Shaotang Zhou, Junchuang He and Huanzhou Xue

    Citation: Journal of Translational Medicine 2019 17:421

    Content type: Research

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  20. The NLRP3 inflammasome plays an important role in mediating podocyte injury in various kidney diseases. The aim of this study was to investigate whether NLRP3 expression associated with podocyte injury was inv...

    Authors: Wei Peng, Gai-qin Pei, Yi Tang, Li Tan and Wei Qin

    Citation: Journal of Translational Medicine 2019 17:406

    Content type: Research

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  21. As a peripheral blood biomarker, the crucial role of long non-coding RNA (lncRNA) HOTAIR has recently been suggested in many types of disorder. Among these reports, few investigations have indicated overexpres...

    Authors: Vahid Ezzatizadeh and Hossein Mozdarani

    Citation: Journal of Translational Medicine 2019 17:404

    Content type: Commentary

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  22. Although there is abundant evidence indicating the connection between triglyceride and type 2 diabetes mellitus (T2DM), few reports or cohort studies confirm that high TG concentration may predict the incidenc...

    Authors: Jing Zhao, Yuan Zhang, Fengjiang Wei, Jiani Song, Zhi Cao, Chen Chen, Kai Zhang, Shuzhi Feng, Yaogang Wang and Wei-Dong Li

    Citation: Journal of Translational Medicine 2019 17:403

    Content type: Research

    Published on:

  23. Bladder cancer (BC) is the most common malignant disease of the urinary tract. Recurrent high grade non muscle invasive BC carries a serious risk for progression and subsequent metastases. The most common prec...

    Authors: Marina Degoricija, Jelena Korac-Prlic, Katarina Vilovic, Tonci Ivanisevic, Benedikt Haupt, Vinko Palada, Marina Petkovic, Ivana Karaman and Janos Terzic

    Citation: Journal of Translational Medicine 2019 17:394

    Content type: Research

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  24. Clinical variables may correlate with lack of response to treatment (primary resistance) or clinical benefit in patients with clear cell renal cell carcinoma (ccRCC) treated with anti-programmed death 1/ligand...

    Authors: Brian W. Labadie, Ping Liu, Riyue Bao, Michael Crist, Ricardo Fernandes, Laura Ferreira, Scott Graupner, Andrew S. Poklepovic, Ignacio Duran, Saman Maleki Vareki, Arjun V. Balar and Jason J. Luke

    Citation: Journal of Translational Medicine 2019 17:386

    Content type: Research

    Published on:

  25. Breast cancer is the most common malignancy in female patients worldwide. Because of its heterogeneity in terms of prognosis and therapeutic response, biomarkers with the potential to predict survival or assis...

    Authors: Xuanwen Bao, Natasa Anastasov, Yanfang Wang and Michael Rosemann

    Citation: Journal of Translational Medicine 2019 17:380

    Content type: Research

    Published on:

  26. The purification of peripheral blood mononuclear cells (PBMCs) by means of density gradient (1.07 g/mL) centrifugation is one of the most commonly used methods in diagnostics and research laboratories as well ...

    Authors: Luigi Coppola, Giovanni Smaldone, Alessandra Cianflone, Simona Baselice, Peppino Mirabelli and Marco Salvatore

    Citation: Journal of Translational Medicine 2019 17:371

    Content type: Methodology

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  27. The purpose of the present work is to underline the importance of obtaining a standardized procedure to ensure and evaluate both clinical and research usability of human tissue samples. The study, which was ca...

    Authors: Margalida Esteva-Socias, María-Jesús Artiga, Olga Bahamonde, Oihana Belar, Raquel Bermudo, Erika Castro, Teresa Escámez, Máximo Fraga, Laura Jauregui-Mosquera, Isabel Novoa, Lorena Peiró-Chova, Juan-David Rejón, María Ruiz-Miró, Paula Vieiro-Balo, Virginia Villar-Campo, Sandra Zazo…

    Citation: Journal of Translational Medicine 2019 17:370

    Content type: Review

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  28. Oxidized low density lipoprotein receptor 1 (OLR1), a type II membrane protein, has been identified as receptor for oxidized low-density lipoprotein. The current study firstly provided evidence that OLR1 regul...

    Authors: Long Jiang, Shanshan Jiang, Wenjie Zhou, Jia Huang, Yongbin Lin, Hao Long and Qingquan Luo

    Citation: Journal of Translational Medicine 2019 17:369

    Content type: Research

    Published on:

  29. Hypertension often presents with microvascular rarefaction (MVR), which is closely associated with impaired angiogenesis. Early detection of MVR is essential for systemic assessment in patient with hypertensio...

    Authors: Jianwen Liang, Yan Li, Long Chen, Wenhao Xia, Guifu Wu, Xinzhu Tong, Chen Su, Jiang He, Xiufang Lin and Jun Tao

    Citation: Journal of Translational Medicine 2019 17:368

    Content type: Research

    Published on:

    The Correction to this article has been published in Journal of Translational Medicine 2020 18:26

  30. Stem cell therapy is investigated as a treatment option for patients with ischemic heart disease. In this study, long-term safety and efficacy of autologous intra-myocardial injections of adipose-derived strom...

    Authors: Abbas Ali Qayyum, Anders Bruun Mathiasen, Steffen Helqvist, Erik Jørgensen, Mandana Haack-Sørensen, Annette Ekblond and Jens Kastrup

    Citation: Journal of Translational Medicine 2019 17:360

    Content type: Research

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  31. Proprotein convertase subtilisin/kexin 9 (PCSK9) has been proposed as a novel target for coronary artery disease (CAD). Familial hypercholesterolemia (FH) is characterized by high prevalence of CAD and major c...

    Authors: Ye-Xuan Cao, Jing-Lu Jin, Di Sun, Hui-Hui Liu, Yuan-Lin Guo, Na-Qiong Wu, Rui-Xia Xu, Cheng-Gang Zhu, Qian Dong, Jing Sun and Jian-Jun Li

    Citation: Journal of Translational Medicine 2019 17:367

    Content type: Research

    Published on:

  32. Acute kidney injury (AKI) has high morbidity and mortality in intensive care units (ICU). It can also lead to chronic kidney disease (CKD), more costs and longer hospital stay. Early identification of AKI is i...

    Authors: Qi Wang, Yi Tang, Jiaojiao Zhou and Wei Qin

    Citation: Journal of Translational Medicine 2019 17:359

    Content type: Research

    Published on:

  33. Pituitary adenoma and meningioma are the most common benign tumors in the central nervous system. Pituitary adenoma associated with meningioma (PAM) is a rare disease and the clinical features and mechanisms o...

    Authors: Haibo Zhu, Yazhou Miao, Yutao Shen, Jing Guo, Weiyan Xie, Sida Zhao, Wei Dong, Yazhuo Zhang and Chuzhong Li

    Citation: Journal of Translational Medicine 2019 17:354

    Content type: Research

    Published on:

  34. Accumulating evidence indicates that CD36 initiates metastasis and correlates with an unfavorable prognosis in cancers. However, there are few reports regarding the roles of CD36 in initiation and metastasis o...

    Authors: Min Deng, Xiaodong Cai, Ling Long, Linying Xie, Hongmei Ma, Youjian Zhou, Shuguang Liu and Chao Zeng

    Citation: Journal of Translational Medicine 2019 17:352

    Content type: Research

    Published on:

  35. Collagen is the major component of the tumor microenvironment and participates in cancer fibrosis. Collagen biosynthesis can be regulated by cancer cells through mutated genes, transcription factors, signaling...

    Authors: Shuaishuai Xu, Huaxiang Xu, Wenquan Wang, Shuo Li, Hao Li, Tianjiao Li, Wuhu Zhang, Xianjun Yu and Liang Liu

    Citation: Journal of Translational Medicine 2019 17:309

    Content type: Review

    Published on:

  36. The aryl hydrocarbon receptor (AhR) is a well-known ligand-activated cytoplasmic transcription factor that contributes to cellular responses against environmental toxins and carcinogens. AhR is activated by a ...

    Authors: Hui Zhao, Lin Chen, Tian Yang, Ya-Long Feng, Nosratola D. Vaziri, Bao-Li Liu, Qing-Quan Liu, Yan Guo and Ying-Yong Zhao

    Citation: Journal of Translational Medicine 2019 17:302

    Content type: Review

    Published on:

  37. BRAF mutations occur in 2–4% non-small cell lung cancer (NSCLC) patients and can be categorized into three functional classes based on signaling mechanism and kinase activity: RAS-independent kinase-activating V6...

    Authors: Quan Lin, Haoran Zhang, Huaxin Ding, Jun Qian, Analyn Lizaso, Jing Lin, Han Han-Zhang, Jianxing Xiang, Yuping Li and Hong Zhu

    Citation: Journal of Translational Medicine 2019 17:298

    Content type: Research

    Published on:

  38. The scientific understanding of long non-coding RNAs (lncRNAs) has improved in recent decades. Nevertheless, there has been little research into the role that lncRNAs play in clear cell renal cell carcinoma (c...

    Authors: Jiang-hui Zeng, Wei Lu, Liang Liang, Gang Chen, Hui-hua Lan, Xiu-Yun Liang and Xu Zhu

    Citation: Journal of Translational Medicine 2019 17:281

    Content type: Research

    Published on:

  39. Ovarian cancer is the leading cause of death in gynecological cancer. Cancer stem cells (CSCs) contribute to the occurrence, progression and resistance. Small nucleolar RNAs (SnoRNAs), a class of small molecul...

    Authors: Wenjing Zhu, Jumin Niu, Miao He, Liwen Zhang, Xuemei Lv, Fangxiao Liu, Longyang Jiang, Jing Zhang, Zhaojin Yu, Lin Zhao, Jia Bi, Yuanyuan Yan, Qian Wei, Hong Huo, Yue Fan, Yuzong Chen…

    Citation: Journal of Translational Medicine 2019 17:259

    Content type: Research

    Published on:

  40. Plexiform fibromyxoma (PF) is a rare gastric tumor often confused with gastrointestinal stromal tumor. These so-called “benign” tumors often present with upper GI bleeding and gastric outlet obstruction. It wa...

    Authors: Sudeep Banerjee, Christopher L. Corless, Markku M. Miettinen, Sangkyu Noh, Rowan Ustoy, Jessica L. Davis, Chih-Min Tang, Mayra Yebra, Adam M. Burgoyne and Jason K. Sicklick

    Citation: Journal of Translational Medicine 2019 17:246

    Content type: Research

    Published on:

  41. Bone metastases occur rarely in patients suffering from malignant melanoma, although their onset severely worsens both prognosis and quality of life. Extracellular vesicles (EVs) including exosomes (Exos) are ...

    Authors: Francesco Mannavola, Marco Tucci, Claudia Felici, Anna Passarelli, Stella D’Oronzo and Francesco Silvestris

    Citation: Journal of Translational Medicine 2019 17:230

    Content type: Research

    Published on:

  42. Immune infiltration may predict survival and have clinical significance in lung cancer. However, immune signatures derived from immune profiling based on bulk tumor transcriptomes have not been systematically ...

    Authors: Xiaodong Yang, Yu Shi, Ming Li, Tao Lu, Junjie Xi, Zongwu Lin, Wei Jiang, Weigang Guo, Cheng Zhan and Qun Wang

    Citation: Journal of Translational Medicine 2019 17:217

    Content type: Research

    Published on:

  43. New treatment options for metastasised high-grade serous carcinoma (HGSC) are urgently needed. HGSC frequently metastasises to the omentum, inducing angiogenesis in the local omental microvasculature to facili...

    Authors: Md Zahidul I. Pranjol, Dmitry A. Zinovkin, Annelie R. T. Maskell, Laura J. Stephens, Sergey L. Achinovich, Dmitry M. Los’, Eldar A. Nadyrov, Michael Hannemann, Nicholas J. Gutowski and Jacqueline L. Whatmore

    Citation: Journal of Translational Medicine 2019 17:216

    Content type: Research

    Published on:

  44. The human epidermal growth factor receptor (HER) family of transmembrane tyrosine kinases is overexpressed and correlates with poor prognosis and decreased survival in many cancers. The receptor family has bee...

    Authors: Sabrina A. Maisel, Derrick Broka, Benjamin Atwell, Thomas Bunch, Robert Kupp, Shiv K. Singh, Shwetal Mehta and Joyce Schroeder

    Citation: Journal of Translational Medicine 2019 17:201

    Content type: Research

    Published on:

  45. One main challenge in ovarian cancer rests on the presence of a relapse and an important metastatic disease, despite extensive surgical debulking and chemotherapy. The difficulty in containing metastatic cance...

    Authors: Jessica Hoarau-Véchot, Cyril Touboul, Najeeb Halabi, Morgane Blot-Dupin, Raphael Lis, Charbel Abi Khalil, Shahin Rafii, Arash Rafii and Jennifer Pasquier

    Citation: Journal of Translational Medicine 2019 17:194

    Content type: Research

    Published on:

  46. Tumors develop by progression through a series of stages. Every cell of the tumor microenvironment is constantly changing in the flow of the cancer progression. It has become clear in recent years that stroma ...

    Authors: F. Lessi, C. Scatena, P. Aretini, M. Menicagli, S. Franceschi, A. G. Naccarato and C. M. Mazzanti

    Citation: Journal of Translational Medicine 2019 17:187

    Content type: Research

    Published on:

  47. Glioblastomas have a high degree of malignancy, high recurrence rate, high mortality rate, and low cure rate. Searching for new markers of glioblastomas is of great significance for improving the diagnosis, pr...

    Authors: Siqi Wang, Fang Liu, Yuhui Wang, Wenliang Fan, Hongyang Zhao, Liying Liu, Chunyuan Cen, Xiaobin Jiang, Min Sun and Ping Han

    Citation: Journal of Translational Medicine 2019 17:179

    Content type: Research

    Published on:

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