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Cancer microenvironment

Section edited by Davide Bedognetti

The Cancer microenvironment section publishes research on the cellular and molecular components of the cancer microenvironment, with a particular focus on translational research that has important implications for the prevention, diagnosis and treatment of human neoplasms.

Submissions that relate to the characterisation of the molecular profile and regulation of cancers at different tumour stages are especially welcome, as are those which identify specific cancer microenvironments that predict tumour incidence, response to therapy and outcome. Laboratory studies of new drugs and biological agents that target cancer microenvironments will also be considered.

Featured articles

Anovel non-hodgkin lymphoma murine model closer to the standard clinical scenario A novel non-Hodgkin lymphoma murine model closer to the standard clinical scenario
Thais Bascuas, et al


Impact of agin on host immune response and survival in melanomaImpact of aging on host immune response and survival in melanoma: an analysis of 3 patient cohorts
Sarah A. Weiss, et al


Differential tumour infiltration by T-Cells characterises intrinsic molecular subtypes in breast cancerDifferential tumor infiltration by T-cells characterizes intrinsic molecular subtypes in breast cancer
M. Miyan, J, et al

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  1. The tumor microenvironment (TME) is a critical player in tumor progression, metastasis and therapy outcomes. Tumor-associated macrophages (TAMs) are a well-recognized core element of the TME and generally char...

    Authors: Ilseon Hwang, Jeong Won Kim, Kris Ylaya, Eun Joo Chung, Haruhisa Kitano, Candice Perry, Jun Hanaoka, Junya Fukuoka, Joon-Yong Chung and Stephen M. Hewitt

    Citation: Journal of Translational Medicine 2020 18:443

    Content type: Research

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  2. Breast cancer is a highly heterogeneous disease, this poses challenges for classification and management. Long non-coding RNAs play acrucial role in the breast cancersdevelopment and progression, especially in...

    Authors: Wei Ma, Fangkun Zhao, Xinmiao Yu, Shu Guan, Huandan Suo, Zuo Tao, Yue Qiu, Yunfei Wu, Yu Cao and Feng Jin

    Citation: Journal of Translational Medicine 2020 18:442

    Content type: Research

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  3. Poly(ADP-ribose) polymerase inhibitors (PARPis) specifically target homologous recombination deficiency (HRD) cells and display good therapeutic effect in women with advanced-stage BRCA1/2-mutated breast and e...

    Authors: Razan Sheta, Magdalena Bachvarova, Marie Plante, Marie-Claude Renaud, Alexandra Sebastianelli, Jean Gregoire, Jamilet Miranda Navarro, Ricardo Bringas Perez, Jean-Yves Masson and Dimcho Bachvarov

    Citation: Journal of Translational Medicine 2020 18:439

    Content type: Research

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  4. Accumulating evidence has demonstrated that immune-related lncRNAs (IRLs) are commonly aberrantly expressed in breast cancer (BC). Thus, we aimed to establish an IRL-based tool to improve prognosis prediction ...

    Authors: Jianguo Lai, Bo Chen, Guochun Zhang, Xuerui Li, Hsiaopei Mok and Ning Liao

    Citation: Journal of Translational Medicine 2020 18:416

    Content type: Research

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  5. Cancer Associated Macrophage-Like cells (CAMLs) are polynucleated circulating stromal cells found in the bloodstream of numerous solid-tumor malignancies. Variations within CAML size have been associated with ...

    Authors: Daniel J. Gironda, Daniel L. Adams, Jianzhong He, Ting Xu, Hui Gao, Yawei Qiao, Ritsuko Komaki, James M. Reuben, Zhongxing Liao, Mariela Blum-Murphy, Wayne L. Hofstetter, Cha-Mei Tang and Steven H. Lin

    Citation: Journal of Translational Medicine 2020 18:413

    Content type: Research

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  6. Methyltransferase-like 3 (METTL3) is a member of the m6A methyltransferase family and acts as an oncogene in cancers. Recent studies suggest that host innate immunity is regulated by the enzymes controlling m6A e...

    Authors: Huan-he Ni, Lin Zhang, He Huang, Shu-qin Dai and Jiang Li

    Citation: Journal of Translational Medicine 2020 18:393

    Content type: Research

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  7. The non-classical human leukocyte antigen (HLA)-G is a strong immunomodulatory molecule. Under physiological conditions, HLA-G induces immunological tolerance in immune privileged tissues, while under pathophy...

    Authors: Michael Friedrich, Christine Stoehr, Simon Jasinski-Bergner, Arndt Hartmann, Sven Wach, Bernd Wullich, André Steven and Barbara Seliger

    Citation: Journal of Translational Medicine 2020 18:371

    Content type: Research

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  8. Cancer stem cells (CSCs) are crucial to the malignant behaviour and poor prognosis of pancreatic ductal adenocarcinoma (PDAC). In recent years, CSC biology has been widely studied, but practical prognostic sig...

    Authors: Zengyu Feng, Minmin Shi, Kexian Li, Yang Ma, Lingxi Jiang, Hao Chen and Chenghong Peng

    Citation: Journal of Translational Medicine 2020 18:360

    Content type: Research

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  9. Epithelial ovarian cancer (EOC) is the most lethal disease among female genital malignant tumors. Peptidylarginine deiminase type II(PADI II) has been shown to enhance a variety of cancers carcinogenesis, incl...

    Authors: Lidong Liu, Zhiwei Zhang, Guoxiang Zhang, Ting Wang, Yingchun Ma and Wei Guo

    Citation: Journal of Translational Medicine 2020 18:357

    Content type: Research

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  10. Distal cholangiocarcinoma is an aggressive malignancy with a dismal prognosis. Diagnostic and prognostic biomarkers for distal cholangiocarcinoma are lacking. The aim of the present study was to identify diffe...

    Authors: Johannes Byrling, Theresa Kristl, Dingyuan Hu, Indira Pla, Aniel Sanchez, Agata Sasor, Roland Andersson, György Marko-Varga and Bodil Andersson

    Citation: Journal of Translational Medicine 2020 18:343

    Content type: Research

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  11. Hypoxia plays an indispensable role in the development of hepatocellular carcinoma (HCC). However, there are few studies on the application of hypoxia molecules in the prognosis predicting of HCC. We aim to id...

    Authors: Baohui Zhang, Bufu Tang, Jianyao Gao, Jiatong Li, Lingming Kong and Ling Qin

    Citation: Journal of Translational Medicine 2020 18:342

    Content type: Research

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  12. Malignant pleural mesothelioma (MPM) is an aggressive neoplasm of the pleura, mainly related to asbestos exposure. As in other solid tumors, malignant cells exhibit high glucose uptake and glycolytic rates wit...

    Authors: Irene Dell’Anno, Elisa Barone, Luciano Mutti, Doris M. Rassl, Stefan J. Marciniak, Roberto Silvestri, Stefano Landi and Federica Gemignani

    Citation: Journal of Translational Medicine 2020 18:341

    Content type: Research

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  13. Duodenal adenocarcinoma (DA) is a rare yet aggressive malignancy, with increasing incidence in the last decades. Its low frequency has hampered a thorough understanding of the pathogenesis of the disease and o...

    Authors: G. Donisi, G. Capretti, N. Cortese, A. Rigamonti, F. Gavazzi, G. Nappo, A. Pulvirenti, M. Sollai, P. Spaggiari, A. Zerbi and F. Marchesi

    Citation: Journal of Translational Medicine 2020 18:340

    Content type: Research

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  14. Immune-related genes (IRGs) have been confirmed to have an important role in tumorigenesis and tumor microenvironment formation. Nevertheless, a systematic analysis of IRGs and their clinical significance in s...

    Authors: Chuan Hu, Bo Chen, Zhangheng Huang, Chuan Liu, Lin Ye, Cailin Wang, Yuexin Tong, Jiaxin Yang and Chengliang Zhao

    Citation: Journal of Translational Medicine 2020 18:337

    Content type: Research

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  15. African American women experience a twofold higher incidence of triple-negative breast cancer (TNBC) and are 40% more likely to die from breast cancer than women of other ethnicities. However, the molecular ba...

    Authors: Xuan Yang, Mohamed Amgad, Lee A. D. Cooper, Yuhong Du, Haian Fu and Andrey A. Ivanov

    Citation: Journal of Translational Medicine 2020 18:334

    Content type: Research

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  16. Recently, it has been reported that miRNA is involved in pterygium, however the exact underlying mechanism in pterygium is unrevealed and require further investigation.

    Authors: Siying He, Yifang Huang, Shiqi Dong, Chen Qiao, Guohua Yang, Shuai Zhang, Chen Wang, Yuting Xu, Fang Zheng and Ming Yan

    Citation: Journal of Translational Medicine 2020 18:332

    Content type: Research

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  17. Colon cancer is a disease with high malignancy and incidence in the world. Tumor immune microenvironment (TIM) and tumor mutational burden (TMB) have been proved to play crucial roles in predicting clinical ou...

    Authors: Xinyi Wang, Jinzhong Duanmu, Xiaorui Fu, Taiyuan Li and Qunguang Jiang

    Citation: Journal of Translational Medicine 2020 18:324

    Content type: Research

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  18. Treatment of human lung squamous cell carcinoma (LUSC) using current targeted therapies is limited because of their diverse somatic mutations without any specific dominant driver mutations. These mutational di...

    Authors: Hae-Yun Jung, Tae Ho Kim, Jong-Eun Lee, Hong Kwan Kim, Jong Ho Cho, Yong Soo Choi, Sumin Shin, Se-Hoon Lee, Hwanseok Rhee, Hee Kyung Lee, Hyun Jung Choi, Hye Yoon Jang, Seungjae Lee, Jung Hee Kang, Young Ae Choi, Sanghyuk Lee…

    Citation: Journal of Translational Medicine 2020 18:307

    Content type: Research

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  19. Immunotherapies targeting glioblastoma (GBM) have led to significant improvements in patient outcomes. TOX is closely associated with the immune environment surrounding tumors, but its role in gliomas is not f...

    Authors: Hao Zhang, Fan Fan, Yuanqiang Yu, Zeyu Wang, Fangkun Liu, Ziyu Dai, Liyang Zhang, Zhixiong Liu and Quan Cheng

    Citation: Journal of Translational Medicine 2020 18:305

    Content type: Research

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    The Correction to this article has been published in Journal of Translational Medicine 2020 18:368

  20. Bladder cancer (BlCa) taxonomy has proved its impact in patient outcome and selection for targeted therapies, but such transcriptomic-based classification has not yet translated to routine practice. Moreover, ...

    Authors: João Lobo, Sara Monteiro-Reis, Catarina Guimarães-Teixeira, Paula Lopes, Isa Carneiro, Carmen Jerónimo and Rui Henrique

    Citation: Journal of Translational Medicine 2020 18:303

    Content type: Research

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  21. The tumor immune microenvironment is a heterogeneous entity. Gene expression analysis allows us to perform comprehensive immunoprofiling and may assist in dissecting the different components of the immune infi...

    Authors: W. S. M. E. Theelen, O. Krijgsman, K. Monkhorst, T. Kuilman, D. D. G. C. Peters, S. Cornelissen, M. A. Ligtenberg, S. M. Willems, J. L. G. Blaauwgeers, C. J. M. van Noesel, D. S. Peeper, M. M. van den Heuvel and K. Schulze

    Citation: Journal of Translational Medicine 2020 18:271

    Content type: Research

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  22. Few studies have delved into the prevalence of distant metastasis (DM +) and survival for patients with lymph node metastases (LN +) by primary site. We aimed to detect differences in distant metastasis and pr...

    Authors: Xin Lou, Jun Li, Ya-Qing Wei, Zhi-Jia Jiang, Ming Chen and Jin-Jin Sun

    Citation: Journal of Translational Medicine 2020 18:266

    Content type: Research

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  23. Patient-derived xenograft (PDX) mouse models of cancer have been recognized as better mouse models that recapitulate the characteristics of original malignancies including preserved tumor heterogeneity, lineag...

    Authors: Zhenyang Liu, Michael Ho-Young Ahn, Tomohiro Kurokawa, Amy Ly, Gong Zhang, Fuyou Wang, Teppei Yamada, Ananthan Sadagopan, Jane Cheng, Cristina R. Ferrone, Andrew S. Liss, Kim C. Honselmann, Gregory R. Wojtkiewicz, Soldano Ferrone and Xinhui Wang

    Citation: Journal of Translational Medicine 2020 18:255

    Content type: Research

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  24. Although oropharyngeal squamous cell carcinoma (OPSCC) with human papillomavirus (HPV) infection has a good prognosis, the accurate prediction of survival and risk of treatment failure is essential to design d...

    Authors: Soohyeon Kwon, Soon-Hyun Ahn, Woo-Jin Jeong, Young Ho Jung, Yun Jung Bae, Jin Ho Paik, Jin-Haeng Chung and Hyojin Kim

    Citation: Journal of Translational Medicine 2020 18:240

    Content type: Research

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  25. Cancer-related mortality in patients with colorectal cancer (CRC) is predominantly caused by development of colorectal liver metastases (CLMs). How to screen the sensitive chemotherapy and targeted therapy is ...

    Authors: Mi Jian, Li Ren, Guodong He, Qi Lin, Wentao Tang, Yijiao Chen, Jingwen Chen, Tianyu Liu, Meiling Ji, Ye Wei, Wenju Chang and Jianmin Xu

    Citation: Journal of Translational Medicine 2020 18:234

    Content type: Research

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  26. As a nucleolar protein associated with ribosome biogenesis, pescadillo homolog 1 (PES1) has been reported to participate in the development of many cancers. However, its role in prostate cancer is not clearly ...

    Authors: Zhenming Jiang, Yuxi Zhang, Xi Chen, Yan Wang, Pingeng Wu, Chengzhang Wu and Dong Chen

    Citation: Journal of Translational Medicine 2020 18:209

    Content type: Research

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  27. Patients with metastatic uveal melanoma (MUM) in the liver usually die within 1 year. The development of new treatments for MUM has been limited by the lack of diverse MUM cell lines and appropriate animal mod...

    Authors: Takahito Sugase, Bao Q. Lam, Meggie Danielson, Mizue Terai, Andrew E. Aplin, J. Silvio Gutkind and Takami Sato

    Citation: Journal of Translational Medicine 2020 18:208

    Content type: Research

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  28. Most tumors develop abnormal fibrotic regions consisting of fibroblasts, immune cells, and a dense extracellular matrix (ECM) immersed in a viscous interstitial fluid, and an abundant fibrotic tumor microenvir...

    Authors: Anette Hauge and Einar K. Rofstad

    Citation: Journal of Translational Medicine 2020 18:207

    Content type: Review

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  29. Increasing evidences have found that the clinical importance of the interaction between hypoxia and immune status in gastric cancer microenvironment. However, reliable prognostic signatures based on combinatio...

    Authors: Yifan Liu, Jianhua Wu, Weiwei Huang, Shaowen Weng, Baochun Wang, Yiming Chen and Hao Wang

    Citation: Journal of Translational Medicine 2020 18:201

    Content type: Research

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  30. Osteosarcoma is a highly metastatic primary bone tumor that predominantly affects adolescents and young adults. A mainstay of treatment in osteosarcoma is removal of the primary tumor. However, surgical excisi...

    Authors: Michelle P. Kallis, Caroline Maloney, Brandon Blank, Samuel Z. Soffer, Marc Symons and Bettie M. Steinberg

    Citation: Journal of Translational Medicine 2020 18:183

    Content type: Research

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  31. Systemic inflammatory response in colorectal cancer (CRC) has been established as a prognostic factor for impaired cancer-specific survival, predominantly in patients with right-sided tumors. On the other hand...

    Authors: Ulf Gunnarsson, Karin Strigård, Sofia Edin, Ioannis Gkekas, Harri Mustonen, Tuomas Kaprio, Camilla Böckelman, Jaana Hagström, Richard Palmqvist and Caj Haglund

    Citation: Journal of Translational Medicine 2020 18:178

    Content type: Research

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  32. Prostate cancer (PCa) is one of the most prevalent cancers that occur in men worldwide. Autophagy-related genes (ARGs) may play an essential role in multiple biological processes of prostate cancer. However, A...

    Authors: Daixing Hu, Li Jiang, Shengjun Luo, Xin Zhao, Hao Hu, Guozhi Zhao and Wei Tang

    Citation: Journal of Translational Medicine 2020 18:160

    Content type: Research

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  33. Despite considering vast majority of the transcribed molecules as merely noise RNA in the last decades, recent advances in the field of molecular biology revealed the mysterious role of long non-coding RNAs (l...

    Authors: Hossein Mozdarani, Vahid Ezzatizadeh and Roghayeh Rahbar Parvaneh

    Citation: Journal of Translational Medicine 2020 18:152

    Content type: Review

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  34. Esophageal squamous cell carcinoma (ESCC) is one of the most prevalent cancers worldwide. Due to its high morbidity and mortality rates, it is urgent to find a molecular target that contributes to esophageal c...

    Authors: Rui Cai, Ping Wang, Xin Zhao, Xiansheng Lu, Ruxia Deng, Xiaoyu Wang, Zhaoji Su, Chang Hong and Jie Lin

    Citation: Journal of Translational Medicine 2020 18:139

    Content type: Research

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  35. Gastric cancer is associated with chronic inflammation, but there is still much to understand about the tumor microenvironment and the underlying tumor-promoting mechanisms. The Map kinase-activated protein ki...

    Authors: Fares Qeadan, Pranshu Bansal, Joshua A. Hanson and Ellen J. Beswick

    Citation: Journal of Translational Medicine 2020 18:137

    Content type: Research

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  36. The most appropriate management for patients with stage IV ovarian cancer remains unclear. Our objective was to understand the main determinants associated with survival and to discuss best surgical management.

    Authors: Yohann Dabi, Cyrille Huchon, Lobna Ouldamer, Sofiane Bendifallah, Pierre Collinet, Alexandre Bricou, Emile Daraï, Marcos Ballester, Vincent Lavoue, Bassam Haddad and Cyril Touboul

    Citation: Journal of Translational Medicine 2020 18:134

    Content type: Research

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  37. Identifying the early-stage colon adenocarcinoma (ECA) patients who have lower risk cancer vs. the higher risk cancer could improve disease prognosis. Our study aimed to explore whether the glandular morpholog...

    Authors: Meng-Yao Ji, Lei Yuan, Shi-Min Lu, Meng-Ting Gao, Zhi Zeng, Na Zhan, Yi-Juan Ding, Zheng-Ru Liu, Ping-Xiao Huang, Cheng Lu and Wei-Guo Dong

    Citation: Journal of Translational Medicine 2020 18:129

    Content type: Research

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  38. Clear cell renal cell carcinoma (ccRCC) is a malignancy characterized by metabolic reprogramming. ABAT and ALDH6A1 are metabolic enzymes. In this study, we aim to investigate the associations of ABAT and ALDH6...

    Authors: Jun Lu, Zhan Chen, Hu Zhao, Huiyue Dong, Ling Zhu, Yi Zhang, Jie Wang, Hehuan Zhu, Qiang Cui, Chuang Qi, Shuiliang Wang, Shushang Chen and Jichun Shao

    Citation: Journal of Translational Medicine 2020 18:101

    Content type: Research

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  39. An increasing number of anti-cancer therapeutic agents target specific mutant proteins that are expressed by many different tumor types. Successful use of these therapies is dependent on the presence or absenc...

    Authors: Sinead Toomey, Aoife Carr, Mateusz Janusz Mezynski, Yasir Elamin, Shereen Rafee, Mattia Cremona, Clare Morgan, Stephen Madden, Khairun I. Abdul-Jalil, Kathy Gately, Angela Farrelly, Elaine W. Kay, Susan Kennedy, Kenneth O’Byrne, Liam Grogan, Oscar Breathnach…

    Citation: Journal of Translational Medicine 2020 18:99

    Content type: Research

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  40. The aim of this study was to investigate the expression of the nuclear receptor PPARγ, together with that of the cyclooxygenases Cox-1 and Cox-2, in breast cancer (BC) tissues and to correlate the data with se...

    Authors: Wanting Shao, Christina Kuhn, Doris Mayr, Nina Ditsch, Magdalena Kailuwait, Verena Wolf, Nadia Harbeck, Sven Mahner, Udo Jeschke, Vincent Cavaillès and Sophie Sixou

    Citation: Journal of Translational Medicine 2020 18:94

    Content type: Research

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  41. Metabolic reprogramming, immune evasion and tumor-promoting inflammation are three hallmarks of cancer that provide new perspectives for understanding the biology of cancer. We aimed to figure out the relation...

    Authors: Wenhui Li, Ming Xu, Yu Li, Ziwei Huang, Jun Zhou, Qiuyang Zhao, Kehao Le, Fang Dong, Cheng Wan and Pengfei Yi

    Citation: Journal of Translational Medicine 2020 18:92

    Content type: Research

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  42. The p.E318K variant of the Melanocyte Inducing Transcription Factor (MITF) has been implicated in genetic predisposition to melanoma as an intermediate penetrance allele. However, the impact of this variant on cl...

    Authors: Giulia Ciccarese, Bruna Dalmasso, William Bruno, Paola Queirolo, Lorenza Pastorino, Virginia Andreotti, Francesco Spagnolo, Enrica Tanda, Giovanni Ponti, Cesare Massone, Francesco Drago, Aurora Parodi, Giovanni Ghigliotti, Maria Antonietta Pizzichetta and Paola Ghiorzo

    Citation: Journal of Translational Medicine 2020 18:78

    Content type: Research

    Published on:

  43. Pancreatic cancer is a major cause of cancer-related mortality. The identification of effective biomarkers is essential in order to improve management of the disease. Yes-associated protein 1 (YAP1) is a downs...

    Authors: Qimin Zhou, Monika Bauden, Roland Andersson, Dingyuan Hu, György Marko-Varga, Jianfeng Xu, Agata Sasor, Hua Dai, Krzysztof Pawłowski, Katarzyna Said Hilmersson, Xi Chen and Daniel Ansari

    Citation: Journal of Translational Medicine 2020 18:77

    Content type: Research

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  44. With the gradual unveiling of tumour heterogeneity, cancer stem cells (CSCs) are now being considered the initial component of tumour initiation. However, the mechanisms of the growth and maintenance of breast...

    Authors: Jianying Pei, Yanxia Wang and Yan Li

    Citation: Journal of Translational Medicine 2020 18:74

    Content type: Research

    Published on:

  45. Translationally controlled tumor protein (TCTP) is linked to lung cancer. However, upon lung cancer carcinogens stimulation, there were no reports on the relationship between TCTP and lung cell carcinogenic ep...

    Authors: Li-Zhong Liu, Menghuan Wang, Qihang Xin, Bowen Wang, George G. Chen and Ming-Yue Li

    Citation: Journal of Translational Medicine 2020 18:66

    Content type: Research

    Published on:

  46. Cancer recurrence is the important problem of cholangiocarcinoma (CCA) patients, lead to a very high mortality rate. Therefore, the identification of candidate markers to predict CCA recurrence is needed in or...

    Authors: Sureerat Padthaisong, Malinee Thanee, Nisana Namwat, Jutarop Phetcharaburanin, Poramate Klanrit, Narong Khuntikeo, Attapol Titapun, Sakkarn Sungkhamanon, Hideyuki Saya and Watcharin Loilome

    Citation: Journal of Translational Medicine 2020 18:64

    Content type: Research

    Published on:

  47. Accumulating evidence suggests that plasminogen activator inhibitor-1 (PAI-1) plays an important role in bladder tumorigenesis by regulating cell cycle. However, it remains unclear whether and how inhibition o...

    Authors: Hideki Furuya, Kazukuni Hayashi, Yoshiko Shimizu, Nari Kim, Yutaro Tsukikawa, Runpu Chen, Yijun Sun, Owen T. M. Chan, Ian Pagano, Rafael Peres, Kanani Hokutan, Fumie Igari, Keith S. Chan and Charles J. Rosser

    Citation: Journal of Translational Medicine 2020 18:57

    Content type: Research

    Published on:

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