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Immunobiology and Immunotherapy

Section edited by Alessandra Cesano

The Immunobiology and Immunotherapy section aims to enrich the communication between basic biological and immunological sciences and the clinical investigation arena.

As immunology has evolved to be a central discipline connected to a wide range of therapeutic areas, the number and diversity of platform technologies has also increased, spanning small molecules, biologics, microbial vectors and cells. Such levels of activity require appropriate means to share new knowledge and to catalyze the development of the field. This section aims to provide such a platform and welcomes submissions across all disciplines, including inflammation, autoimmunity, transplantation, metabolic disorders.

The section was founded with the Society for Immunotherapy of Cancer (SITC) under the title "Tumor immunology and biological cancer therapy" and Pedro Romero was the founding Section Editor.

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  1. AMP-activated protein kinase (AMPK) is a ubiquitous sensor of energy and nutritional status in eukaryotic cells. It plays a key role in regulating cellular energy homeostasis and multiple aspects of cell metab...

    Authors: Yinxing Cui, Junhua Chen, Zhao Zhang, Houyin Shi, Weichao Sun and Qian Yi
    Citation: Journal of Translational Medicine 2023 21:892
    Content type: Review Published on:

  2. Lung neuroendocrine neoplasms (LungNENs) comprise a heterogeneous group of tumors ranging from indolent lesions with good prognosis to highly aggressive cancers. Carcinoids are the rarest LungNENs, display low...

    Authors: Ricardo Blázquez-Encinas, Víctor García-Vioque, Teresa Caro-Cuenca, María Trinidad Moreno-Montilla, Federica Mangili, Emilia Alors-Pérez, Sebastian Ventura, Aura D. Herrera-Martínez, Paula Moreno-Casado, Marco A. Calzado, Ángel Salvatierra, María A. Gálvez-Moreno, Lynnette Fernandez-Cuesta, Matthieu Foll, Raúl M. Luque, Nicolas Alcala…
    Citation: Journal of Translational Medicine 2023 21:879
    Content type: Research Published on:

  3. Pancreatic cancer is a lethal disease with a high mortality rate. The difficulty of early diagnosis is one of its primary causes. Therefore, we aimed to discover non-invasive biomarkers that facilitate the ear...

    Authors: Youngmin Han, Keum Ji Jung, Unchong Kim, Chan Il Jeon, Kwangbae Lee and Sun Ha Jee
    Citation: Journal of Translational Medicine 2023 21:878
    Content type: Research Published on:

  4. Psoriasis is an inflammatory disease mediated by helper T (Th)17 and Th1 cells. MicroRNA-125a (miR-125a) is reduced in the lesional skin of psoriatic patients. However, the mechanism by which miR-125a particip...

    Authors: Kexiang Yan, Fuxin Zhang, Jie Ren, Qiong Huang, Nikhil Yawalkar and Ling Han
    Citation: Journal of Translational Medicine 2023 21:678
    Content type: Research Published on:

  5. Rheumatoid arthritis (RA) is a chronic inflammatory illness that mostly affects the joints of the hands and feet and can reduce life expectancy by an average of 3 to 10 years. Although tremendous progress has ...

    Authors: Yu Cao, Ying Yang, Qingfeng Hu and Guojun Wei
    Citation: Journal of Translational Medicine 2023 21:616
    Content type: Research Published on:

  6. Ankylosing spondylitis (AS) is an autoimmune disease with a genetic correlation and is characterized by inflammation in the axial skeleton and sacroiliac joints. Many AS patients also have inflammatory bowel d...

    Authors: Xinzhe Feng, Shanbang Zhu, Junjie Qiao, Zhou Ji, Bole Zhou and Weidong Xu
    Citation: Journal of Translational Medicine 2023 21:573
    Content type: Research Published on:

  7. Celiac disease (CeD) is a primary malabsorption syndrome with no specific therapy, which greatly affects the quality of life. Since the pathogenesis of CeD remains riddled, based on multiple transcriptome prof...

    Authors: Shuze Chen, Xiuying Liu, Zhi Wang, Dekai Zheng, Ying Wang, Yiling Yan, Xiaojie Peng, Qiujuan Ye and Ye Chen
    Citation: Journal of Translational Medicine 2023 21:497
    Content type: Research Published on:

  8. We sought to identify novel molecular subtypes of ulcerative colitis (UC) based on large-scale cohorts and establish a clinically applicable subtyping system for the precision treatment of the disease.

    Authors: Shaocong Mo, Bryan Jin, Yujen Tseng, Lingxi Lin, Lishuang Lin, Xin Shen, Huan Song, Mingjia Kong, Zhongguang Luo, Yiwei Chu, Chen Jiang, Zhiwei Cao, Jie Liu and Feifei Luo
    Citation: Journal of Translational Medicine 2023 21:466
    Content type: Research Published on:

  9. Upregulation of the PD-L1 (CD274) immune checkpoint ligand on the tumor surface facilitates tumor immune escape and limits the application of immunotherapy in various cancers, including breast cancer. However,...

    Authors: Xinrui Dong, Huijuan Dai, Yanping Lin, Xiaonan Sheng, Ye Li, Yaohui Wang, Xueli Zhang, Shuheng Jiang, Wenjin Yin and Jinsong Lu
    Citation: Journal of Translational Medicine 2023 21:400
    Content type: Research Published on:

  10. The ubiquitin protein ligase E3C (UBE3C) has been reported to play an oncogenic role in breast cancer (BRCA). This work further investigates the effect of UBE3C on the radioresistance of BRCA cells.

    Authors: Yansu Wang, Ming Liu, Xiaoqian Liu and Xianling Guo
    Citation: Journal of Translational Medicine 2023 21:321
    Content type: Research Published on:

  11. The clinical heterogeneity of SLE with its complex pathogenesis remains challenging as we strive to provide optimal management. The contribution of platelets to endovascular homeostasis, inflammation and immun...

    Authors: MacIntosh G. Cornwell, Hanane El Bannoudi, Elliot Luttrell-Williams, Alexis Engel, Tessa J. Barrett, Khrystyna Myndzar, Peter Izmirly, H. Michael Belmont, Robert Clancy, Kelly V. Ruggles, Jill P. Buyon and Jeffrey S. Berger
    Citation: Journal of Translational Medicine 2023 21:247
    Content type: Research Published on:

  12. Chimeric antigen receptor macrophage (CAR-M) therapy is a novel cancer immunotherapy approach that integrates CAR structure and macrophage functions. CAR-M therapy has shown unique and impressive antitumor eff...

    Authors: Yi Huo, Han Zhang, Longqi Sa, Wenjing Zheng, Yang He, Haohan Lyu, Mengjie Sun, Lingling Zhang, Lequn Shan, Angang Yang and Tao Wang
    Citation: Journal of Translational Medicine 2023 21:225
    Content type: Research Published on:

  13. Despite remarkable progress, the immunotherapies currently used in the clinic, such as immune checkpoint blockade (ICB) therapy, still have limited efficacy against many types of solid tumors. One major barrie...

    Authors: Meir Azulay, Michal Shahar, Eitan Shany, Eti Elbaz, Sveta Lifshits, Marie Törngren, Adam Friedmann, Robert Kramer and Gunnar Hedlund
    Citation: Journal of Translational Medicine 2023 21:222
    Content type: Research Published on:

  14. Gastrointestinal stromal tumors (GISTs) are the prevailing sarcomas of the gastrointestinal tract. Tyrosine kinase inhibitors (TKIs) therapy, exemplified by Imatinib mesylate (IM), constitutes the established ...

    Authors: Yu Zhao, Zuyi Weng, Xuan Zhou, Zhi Xu, Bei Cao, Bin Wang and Juan Li
    Citation: Journal of Translational Medicine 2023 21:219
    Content type: Research Published on:

  15. Psoriasis is a common, chronic and relapsing immune-related inflammatory dermal disease. Patients with psoriasis suffering from the recurrences is mainly caused by immune response disorder. Thus, our study is ...

    Authors: Yingxi Li, Lin Li, Yao Tian, Jing Luo, Junkai Huang, Litao Zhang, Junling Zhang, Xiaoxia Li and Lizhi Hu
    Citation: Journal of Translational Medicine 2023 21:182
    Content type: Research Published on:

  16. Muscle-invasive urothelial bladder cancer (MIBC) is associated with limited response rates to systemic therapy, risk of recurrence and death. Tumor infiltrating immune cells have been associated with outcome a...

    Authors: Florestan J. Koll, Severine Banek, Luis Kluth, Jens Köllermann, Katrin Bankov, Felix K.-H. Chun, Peter J. Wild, Andreas Weigert and Henning Reis
    Citation: Journal of Translational Medicine 2023 21:124
    Content type: Research Published on:

  17. Inadequate immunity caused by poor immune surveillance leads to tumorigenesis, while excessive immunity due to breakdown of immune tolerance causes autoimmune genesis. Although the function of immunity during ...

    Authors: Yuan Sui, Shuping Li, Xue-Qi Fu, Zhizhuang Joe Zhao and Shu Xing
    Citation: Journal of Translational Medicine 2023 21:109
    Content type: Research Published on:

  18. CD4+ cytotoxic T cells (CD4 CTLs) are CD4+ T cells with major histocompatibility complex-II-restricted cytotoxic function. Under pathologic conditions, CD4 CTLs hasten the development of autoimmune disease or vir...

    Authors: Ziyi Chen, Meng Zhang, Yufeng Liu, Zhe Chen, Ling Wang, Wenjuan Wang, Jincheng Wang, Mingqian He, Bingyin Shi and Yue Wang
    Citation: Journal of Translational Medicine 2023 21:74
    Content type: Research Published on:

  19. Eosinophilic esophagitis (EoE) is a chronic immune-mediated rare disease, characterized by esophageal dysfunctions. It is likely to be primarily activated by food antigens and is classified as a chronic diseas...

    Authors: Luca Massimino, Alberto Barchi, Francesco Vito Mandarino, Salvatore Spanò, Luigi Antonio Lamparelli, Edoardo Vespa, Sandro Passaretti, Laurent Peyrin-Biroulet, Edoardo Vincenzo Savarino, Vipul Jairath, Federica Ungaro and Silvio Danese
    Citation: Journal of Translational Medicine 2023 21:46
    Content type: Research Published on:

  20. Ulcerative colitis (UC) is a form of chronic inflammatory bowel disease of nonspecific origin. This study used an RNA-Sequencing (RNA-Seq) approach to evaluate the transcriptomic landscape of a well-stratified...

    Authors: Xiaoli Pang, Hongxiao Song, Xiaolu Li, Fengchao Xu, Bingxun Lei, Fei Wang, Jing Xu, Lingli Qi, Libo Wang and Guangyun Tan
    Citation: Journal of Translational Medicine 2023 21:30
    Content type: Research Published on:

  21. Breast cancer is a complex disease with a highly immunosuppressive tumor microenvironment, and has limited clinical response to immune checkpoint blockade (ICB) therapy. T-helper 2 (Th2) cells, an important co...

    Authors: Yuru Chen, Jiazheng Sun, Yachan Luo, Jiazhou Liu, Xiaoyu Wang, Rui Feng, Jing Huang, Huimin Du, Qin Li, Jinxiang Tan, Guosheng Ren, Xiaoyi Wang and Hongzhong Li
    Citation: Journal of Translational Medicine 2022 20:615
    Content type: Research Published on:

  22. To identify novel DNA methylation-regulated differentially expressed genes (MeDEGs) in RA by integrated analysis of DNA methylation and RNA-Seq data.

    Authors: Runrun Zhang, Cen Chang, Yehua Jin, LingXia Xu, Ping Jiang, Kai Wei, Linshuai Xu, Shicheng Guo, Songtao Sun and Dongyi He
    Citation: Journal of Translational Medicine 2022 20:481
    Content type: Research Published on:

  23. Immunotherapy has dramatically improved cancer treatment by inhibiting or activating specific cell receptors, thus unleashing the host anti-tumor response. However, the engagement of the three main immune chec...

    Authors: Claudia Giampietri, Francesca Scatozza, Elena Crecca, Virginia Vigiano Benedetti, Pier Giorgio Natali and Antonio Facchiano
    Citation: Journal of Translational Medicine 2022 20:467
    Content type: Research Published on:

  24. Metastasis is a major obstacle in the treatment of cervical cancer (CC), and SPOP-mediated regulatory effects are involved in metastasis. However, the mechanisms have not been fully elucidated.

    Authors: Jiangchun Wu, Yong Wu, Qinhao Guo, Siyu chen, Simin Wang, Xiaohua Wu, Jun Zhu and Xingzhu Ju
    Citation: Journal of Translational Medicine 2022 20:384
    Content type: Research Published on:

  25. The IO Score is a 27-gene immuno-oncology (IO) classifier that has previously predicted benefit to immune checkpoint inhibitor (ICI) therapy in triple negative breast cancer (TNBC) and non-small cell lung canc...

    Authors: Robert S. Seitz, Michael E. Hurwitz, Tyler J. Nielsen, Daniel B. Bailey, Matthew G. Varga, Brian Z. Ring, Carrie F. Metts, Brock L. Schweitzer, Kimberly McGregor and Douglas T. Ross
    Citation: Journal of Translational Medicine 2022 20:370
    Content type: Research Published on:

  26. To construct a predictive model of immunotherapy efficacy for patients with lung squamous cell carcinoma (LUSC) based on the degree of tumor-infiltrating immune cells (TIIC) in the tumor microenvironment (TME).

    Authors: Lingge Yang, Shuli Wei, Jingnan Zhang, Qiongjie Hu, Wansong Hu, Mengqing Cao, Long Zhang, Yongfang Wang, Pingli Wang and Kai Wang
    Citation: Journal of Translational Medicine 2022 20:364
    Content type: Research Published on:

  27. Approximately 8–9% of the world’s population is affected by autoimmune diseases, and yet the mechanism of autoimmunity trigger is largely understudied. Two unique cell death modalities, ferroptosis and pyropto...

    Authors: Danfeng Zhang, Yadan Li, Chunyan Du, Lina Sang, Liu Liu, Yingmei Li, Fang Wang, Wenjuan Fan, Ping Tang, Sidong Zhang, Dandan Chen, Yanmei Wang, Xiaoyi Wang, Xinsheng Xie, Zhongxing Jiang, Yongping Song…
    Citation: Journal of Translational Medicine 2022 20:363
    Content type: Research Published on:

  28. Except for B7-CD28 family members, more novel immune checkpoints are being discovered. They are closely associated with tumor immune microenvironment and regulate the function of many immune cells. Various can...

    Authors: Nan Sun, Yuejun Luo, Bo Zheng, Zhihui Zhang, Chaoqi Zhang, Zhen Zhang, Guochao Zhang, Fengwei Tan, Qi Xue, Shugeng Gao and Jie He
    Citation: Journal of Translational Medicine 2022 20:332
    Content type: Research Published on:

  29. Ulcerative colitis (UC) is a heterogeneous disorder with complex pathogenesis. Therefore, in the present study, we aimed to assess genome-wide DNA methylation changes associated explicitly with the pathogenesi...

    Authors: Hao-ming Xu, Jing Xu, Mei-feng Yang, Yu-jie Liang, Quan-zhou Peng, Yuan Zhang, Cheng-mei Tian, Yu-qiang Nie, Li-sheng Wang, Jun Yao and De-feng Li
    Citation: Journal of Translational Medicine 2022 20:289
    Content type: Research Published on:

  30. TIGIT/CD155 has attracted widespread attention as a new immune checkpoint and a potential target for cancer immunotherapy. In our study, we evaluated the role of TIGIT/CD155 checkpoints in the progression of c...

    Authors: Lu Liu, Aihong Wang, Xiaoli Liu, Sai Han, Yu Sun, Junhua Zhang, Lingyu Guo and Youzhong Zhang
    Citation: Journal of Translational Medicine 2022 20:280
    Content type: Research Published on:

  31. High immune infiltration is associated with favourable prognosis in patients with non-small-cell lung cancer (NSCLC), but an automated workflow for characterizing immune infiltration, with high validity and re...

    Authors: Huan Lin, Xipeng Pan, Zhengyun Feng, Lixu Yan, Junjie Hua, Yanting Liang, Chu Han, Zeyan Xu, Yumeng Wang, Lin Wu, Yanfen Cui, Xiaomei Huang, Zhenwei Shi, Xin Chen, Xiaobo Chen, Qingling Zhang…
    Citation: Journal of Translational Medicine 2022 20:261
    Content type: Research Published on:

  34. Spondyloarthritis (SpA) and rheumatoid arthritis (RA) are chronic autoimmune diseases, but they are usually difficult to distinguish in the early stage of the diseases. The purpose of this study is to explore ...

    Authors: Jiaqian Wang, Yuan Xue and Liang Zhou
    Citation: Journal of Translational Medicine 2022 20:196
    Content type: Research Published on:

  35. Pemphigus is an autoimmune skin disease. Ectopic lymphoid-like structures (ELSs) were found to be commonly present in the pemphigus lesions, presumably supporting in situ desmoglein (Dsg)-specific antibody pro...

    Authors: Zi-xuan Huang, Peng Qu, Kan-kan Wang, Jie Zheng, Meng Pan and Hai-qin Zhu
    Citation: Journal of Translational Medicine 2022 20:182
    Content type: Research Published on:

  36. To evaluate the capability of basal and one-month differed white blood cells (WBC), neutrophil, lymphocyte and platelet values and their ratios (neutrophils-to-lymphocytes ratio, NLR, and platelets-to-lymphocy...

    Authors: Michele Guida, Nicola Bartolomeo, Davide Quaresmini, Pietro Quaglino, Gabriele Madonna, Jacopo Pigozzo, Anna Maria Di Giacomo, Alessandro Marco Minisini, Marco Tucci, Francesco Spagnolo, Marcella Occelli, Laura Ridolfi, Paola Queirolo, Ivana De Risi, Monica Valente, Angela Monica Sciacovelli…
    Citation: Journal of Translational Medicine 2022 20:159
    Content type: Research Published on:

  37. The phagocytosis checkpoints of CD47/SIRPα, PD1/PDL1, CD24/SIGLEC10, and MHC/LILRB1 have shown inhibited phagocytosis of macrophages in distinct tumors. However, phagocytosis checkpoints and their therapeutic ...

    Authors: Hui Yang, Meimei Yan, Wei Li and Linping Xu
    Citation: Journal of Translational Medicine 2022 20:140
    Content type: Research Published on:

  38. Immune checkpoint blockade therapy has revolutionized non-small cell lung cancer treatment. However, not all patients respond to this therapy. Assessing the tumor expression of immune checkpoint molecules, inc...

    Authors: Yen-Yu Lin, Lei-Chi Wang, Yu-Han Hsieh, Yu-Ling Hung, Yung-An Chen, Yu-Chieh Lin, Yen-Yin Lin and Teh-Ying Chou
    Citation: Journal of Translational Medicine 2022 20:131
    Content type: Research Published on:

  39. Autoimmunity has emerged as a characteristic of the post-COVID syndrome (PCS), which may be related to sex. In order to further investigate the relationship between SARS-CoV-2 and autoimmunity in PCS, a clinic...

    Authors: Manuel Rojas, Yhojan Rodríguez, Yeny Acosta-Ampudia, Diana M. Monsalve, Chengsong Zhu, Quan-Zhen Li, Carolina Ramírez-Santana and Juan-Manuel Anaya
    Citation: Journal of Translational Medicine 2022 20:129
    Content type: Commentary Published on:

  40. Triple negative breast cancer (TNBC) is an aggressive breast cancer for which there is currently no targeted therapy. Tumor-infiltrating B-cells (TIB) have been observed in tumor tissues of TNBC patients, but ...

    Authors: Nicole J. Toney, Lynn M. Opdenaker, Kader Cicek, Lisa Frerichs, Christopher Ryan Kennington, Samuel Oberly, Holly Archinal, Rajasekharan Somasundaram and Jennifer Sims-Mourtada
    Citation: Journal of Translational Medicine 2022 20:112
    Content type: Research Published on:

  41. Graft-versus-host disease (GvHD) is a critical complication after allogeneic hematopoietic stem cell transplantation (HSCT). The immunosuppressants given to patients undergoing allogeneic HSCT disturb the microbi...

    Authors: Jin-Ah Beak, Min-Jung Park, Se-Young Kim, JooYeon Jhun, Jin Seok Woo, Jeong Won Choi, Hyun Sik Na, Soon Kyu Lee, Jong Young Choi and Mi-La Cho
    Citation: Journal of Translational Medicine 2022 20:104
    Content type: Research Published on:

  42. Interstitial cystitis/bladder pain syndrome (IC/BPS) is a disorder characterized by bladder pain upon filling which severely affects quality of life. Clinical presentation can vary. Local inflammatory events t...

    Authors: Robert M. Moldwin, Vishaan Nursey, Oksana Yaskiv, Siddhartha Dalvi, Eric J. Macdonald, Michael Funaro, Chengliang Zhang, William DeGouveia, Marina Ruzimovsky, Horacio R. Rilo, Edmund J. Miller, Souhel Najjar, Inna Tabansky and Joel N. H. Stern
    Citation: Journal of Translational Medicine 2022 20:97
    Content type: Research Published on:

  43. Rheumatoid arthritis (RA) is a progressive systemic autoimmune disease that is characterized by infiltration of inflammatory cells into the hyperplastic synovial tissue, resulting in subsequent destruction of ...

    Authors: Jin-Sil Park, Donghyun Lee, SeungCheon Yang, Ha Yeon Jeong, Hyun Sik Na, Keun-Hyung Cho, JeongWon Choi, Heebeom Koo, Mi-La Cho and Sung-Hwan Park
    Citation: Journal of Translational Medicine 2022 20:85
    Content type: Research Published on:

  44. Natural killer (NK) cells mediate the anti-tumoral immune response as an important component of innate immunity. The aim of this study was to investigate the prognostic significance and functional implication ...

    Authors: Hee Young Na, Yujun Park, Soo Kyung Nam, Jiwon Koh, Yoonjin Kwak, Sang-Hoon Ahn, Do Joong Park, Hyung-Ho Kim, Kyu Sang Lee and Hye Seung Lee
    Citation: Journal of Translational Medicine 2021 19:529
    Content type: Research Published on:

  45. Osteoarthritis (OA), which is due to the progressive loss and degeneration of articular cartilage, is the leading cause of disability worldwide. Therefore, it is of great significance to explore OA biomarkers ...

    Authors: YaGuang Han, Jun Wu, ZhenYu Gong, YiQin Zhou, HaoBo Li, Bo Wang and QiRong Qian
    Citation: Journal of Translational Medicine 2021 19:522
    Content type: Research Published on:

  46. Bullous pemphigoid (BP) is the most common autoimmune bullous skin disease that affects primarily patients older than 60 years. The majority of BP cases are spontaneous, but BP can also be triggered by certain...

    Authors: Karim Chouchane, Giovanni Di Zenzo, Dario Pitocco, Laura Calabrese and Clara De Simone
    Citation: Journal of Translational Medicine 2021 19:520
    Content type: Review Published on:

  47. Over the past decade, human Interleukin 33 (hIL-33) has emerged as a key contributor to the pathogenesis of numerous inflammatory diseases. Despite the existence of several commercial hIL-33 assays spanning mu...

    Authors: Elaine Mai, Joyce Chan, Levina Goon, Braeden K. Ego, Jack Bevers, Tiffany Wong, Manda Wong, Racquel Corpuz, Hongkang Xi, Jia Wu, Kellen Schneider, Dhaya Seshasayee, Michele Grimbaldeston, Gerald Nakamura, Vahan B. Indjeian, Menno van Lookeren Campagne…
    Citation: Journal of Translational Medicine 2021 19:517
    Content type: Methodology Published on:

  48. The development of Bruton’s tyrosine kinase inhibitors (BTKi) for the treatment of chronic lymphocytic leukaemia (CLL) has provided a highly effective and relatively non-toxic alternative to conventional chemo...

    Authors: Joanne E. Davis, Chia Sharpe, Kylie Mason, Constantine S. Tam, Rachel M. Koldej and David S. Ritchie
    Citation: Journal of Translational Medicine 2021 19:473
    Content type: Research Published on:

  49. Toll-like receptors (TLRs) on neutrophils play a crucial role in detecting pathogens and organ/tissue injury in acute-on-chronic liver failure (ACLF). However, little is known about the exact mechanisms and po...

    Authors: Yi Zhang, Wei Wu, Yijie Wang, Lingjia Tong, Meng Hong, Qi Xia and Zhi Chen
    Citation: Journal of Translational Medicine 2021 19:465
    Content type: Research Published on:

  50. Patients with rheumatoid arthritis (RA) have increased levels of interleukin-18 (IL-18) and decreased levels of IL-18 binding protein (IL-18BP) in the serum and synovial fluid (SF) compared to those in patient...

    Authors: Hong Ki Min, Sehee Kim, Ji-Yeon Lee, Kyoung-Woon Kim, Sang-Heon Lee and Hae-Rim Kim
    Citation: Journal of Translational Medicine 2021 19:392
    Content type: Research Published on:
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