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Translational cancer biology

Section edited by Cristina Maccalli

This section aims to provide a platform for the communication and dissemination of advances in cancer biology and their translational applications. Studies considered for publication include those dissecting the mechanisms of transformation, progression and metastatization, the biology of cancer stem cells and their immunological properties, the mechanisms undergoing the epithelial-to mesenchymal (EMT) transition and tumor dormancy, their relationship with immune functions and the mechanisms undergoing cancer resistance to therapies. 

This section is also dedicated to those investigations dedicated to the translational aspects and the development of novel therapies related to the aforementioned themes and the identification of patient’s responsiveness and outcome to therapies.

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  2. Circular RNAs (circRNAs) are pivotal regulators of various human cancers and circ-ERBB2 is abnormally expressed in breast cancer cells. However, the role and mechanism of circ-ERBB2 in HER2-positive breast can...

    Authors: Jin-xiu Zhong, Yun-yuan Kong, Rong-guang Luo, Guo-jin Xia, Wen-xing He, Xue-zhong Chen, Wei-wei Tan, Qing-jie Chen, Yu-yin Huang and Yan-xing Guan
    Citation: Journal of Translational Medicine 2021 19:455
    Content type: Research Published on:

  3. Gastric cancer (GC) is the fifth most commonly diagnosed cancer worldwide. Due to the dismal prognosis, identifying novel therapeutic targets in GC is urgently needed. Evidences have shown that miRNAs played c...

    Authors: Yixun Lu, Benlong Zhang, Baohua Wang, Di Wu, Chuang Wang, Yunhe Gao, Wenquan Liang, Hongqing Xi, Xinxin Wang and Lin Chen
    Citation: Journal of Translational Medicine 2021 19:432
    Content type: Research Published on:

  4. Colorectal cancer is one of the most common malignancy in the world. It has been reported that cancer stem cells (CSCs) serve as the primary drivers of tumorigenesis and tumor progression. There is an urgent n...

    Authors: Yifan Li, Jing Xun, Botao Wang, Yuan Ma, Lanqiu Zhang, Lei Yang, Ruifang Gao, Jun Guan, Tianyu Liu, Hejun Gao, Ximo Wang and Qi Zhang
    Citation: Journal of Translational Medicine 2021 19:429
    Content type: Research Published on:

  5. This research aimed to investigate the expression and function of FAM83A in the proliferation and metastasis in head and neck squamous cell carcinoma (HNSCC). FAM83A mRNA and protein expressions in HNSCC were ...

    Authors: Huan Ji, Haiyang Song, Zeyu Wang, Pengfei Jiao, Jiani Xu, Xuan Li, Hongming Du, Heming Wu and Yi Zhong
    Citation: Journal of Translational Medicine 2021 19:423
    Content type: Research Published on:

  6. Clear cell renal cell carcinoma (ccRCC) is the most common malignant tumor of the kidney. New and reliable biomarkers are in urgent need for ccRCC diagnosis and prognosis. The CENP family is overexpressed in m...

    Authors: Qi Wang, Jiaju Xu, Zhiyong Xiong, Tianbo Xu, Jingchong Liu, Yuenan Liu, Jiaping Chen, Jian Shi, Yi Shou, Changjie Yue, Di Liu, Huageng Liang, Hongmei Yang, Xiong Yang and Xiaoping Zhang
    Citation: Journal of Translational Medicine 2021 19:417
    Content type: Research Published on:

  7. Cancer stem cells (CSCs) are key regulators in the processes of tumor initiation, progression, and recurrence. The mechanism that maintains their stemness remains enigmatic, although the role of several long n...

    Authors: Yu-Shui Ma, Xiao-Li Yang, Yu-Shan Liu, Hua Ding, Jian-Jun Wu, Yi Shi, Cheng-You Jia, Gai-Xia Lu, Dan-Dan Zhang, Hui-Min Wang, Pei-Yao Wang, Fei Yu, Zhong-Wei Lv, Gao-Ren Wang, Ji-Bin Liu and Da Fu
    Citation: Journal of Translational Medicine 2021 19:400
    Content type: Research Published on:

  8. EMT is an important biological process in the mechanism of tumor invasion and metastasis. However, there are still many unknowns about the specific mechanism of EMT in tumor. At present, a comprehensive analys...

    Authors: Yang Yang, Mingyang Feng, LiangLiang Bai, Weiting Liao, Kexun Zhou, Mengxi Zhang, Qiuji Wu, Feng Wen, Wanting Lei, Pengfei Zhang, Nan Zhang, Jiaxing Huang and Qiu Li
    Citation: Journal of Translational Medicine 2021 19:391
    Content type: Research Published on:

  9. The recurrence and metastasis of nasopharyngeal cancer (NPC) may be mainly attributed to the persistence of cancer stem cells (CSCs); however, the linkage mechanism has yet to be fully elucidated.

    Authors: Mengyang Zhao, Zibo Tang, Yijun Wang, Jiaojiao Ding, Ying Guo and Tianhui Gao
    Citation: Journal of Translational Medicine 2021 19:387
    Content type: Research Published on:

  10. Ubiquitin-conjugating enzyme E2T (UBE2T) acts as an oncogene in various types of cancer. However, the mechanisms behind its oncogenic role remain unclear in lung cancer. This study aims to explore the function...

    Authors: Jinhong Zhu, Haijiao Ao, Mingdong Liu, Kui Cao and Jianqun Ma
    Citation: Journal of Translational Medicine 2021 19:374
    Content type: Research Published on:

  11. Although the rapid development of diagnosis and treatment has improved prognosis in early breast cancer, challenges from different therapeutic response remain due to breast cancer heterogeneity. DEAD-box helic...

    Authors: Shan Li, Jinfei Ma, Ang Zheng, Xinyue Song, Si Chen and Feng Jin
    Citation: Journal of Translational Medicine 2021 19:334
    Content type: Research Published on:

  12. Pancreatic cancer (PC) is one of the most fatal digestive system cancers. tripartite motif-29 (TRIM29) has been reported as oncogene in several human cancers. However, the precise role and underlying signal ca...

    Authors: Xueqiang Deng, Xiaowei Fu, Hong Teng, Lu Fang, Bo Liang, Rengui Zeng, Lian Chen and Yeqing Zou
    Citation: Journal of Translational Medicine 2021 19:332
    Content type: Research Published on:

  13. Circular RNA (circRNA) has been demonstrated to participate in cervical cancer development. In this study, we analyzed the role of hsa_circ_0000520 in cervical cancer.

    Authors: Qingling Zheng, Jin Zhang, Ting Zhang, Yanxiang Liu, Xiuluan Du, Xin Dai and Donghua Gu
    Citation: Journal of Translational Medicine 2021 19:314
    Content type: Research Published on:

  14. Colorectal cancer (CRC) is a common malignant tumour of the digestive tract that is characterized by high patient morbidity and mortality rates. Claudin-7 (Cldn7), a tight junction protein, was recently report...

    Authors: Chang Xu, Yu-han Ding, Kun Wang, Mengdi Hao, Huimin Li and Lei Ding
    Citation: Journal of Translational Medicine 2021 19:311
    Content type: Research Published on:

  15. Metastasis and invasion are crucial in determining the mortality of cervical carcinoma (CC) patients. The epithelial–mesenchymal transition (EMT) is now a universal explanation for the mechanisms of tumor meta...

    Authors: Haoqi Zhao, Lan Wang, Shufang Wang, Xihua Chen, Min Liang, Xin Zhang, Jiedong Wang and Xiangbo Xu
    Citation: Journal of Translational Medicine 2021 19:295
    Content type: Research Published on:

  16. Colorectal cancer is the third most common diagnosis. Oxaliplatin is used as first-line treatment of colon cancer. However, oxaliplatin resistance greatly reduces its therapeutic effect. SRPK1 involves in pre-...

    Authors: Jing-Qiang Huang, He-Feng Li, Jing Zhu, Jun-Wei Song, Xian-Bin Zhang, Peng Gong, Qiu-Yu Liu, Chun-Hui Zhou, Liang Wang and Li-Yun Gong
    Citation: Journal of Translational Medicine 2021 19:280
    Content type: Research Published on:

  18. Intratumour heterogeneous gene expression among cancer and cancer stem cells (CSCs) can cause failure of current targeted therapies because each drug aims to target the function of a single gene. Long mononucl...

    Authors: Narumol Bhummaphan, Piyapat Pin-on, Preeyaporn Plaimee Phiboonchaiyanan, Jirattha Siriluksana, Chatchawit Aporntewan, Pithi Chanvorachote and Apiwat Mutirangura
    Citation: Journal of Translational Medicine 2021 19:231
    Content type: Research Published on:

  19. There is growing evidence discussing the role of long non-coding RNAs (lncRNAs) in cervical cancer (CC). We performed this study to explore the impact of exosomal lncRNA urothelial cancer-associated 1 (UCA1) i...

    Authors: Zhihui Gao, Qianqing Wang, Mei Ji, Xiangcui Guo, Li Li and Xiaoke Su
    Citation: Journal of Translational Medicine 2021 19:229
    Content type: Research Published on:

  20. It has been established that microRNA (miR)-449a is anti-tumorigenic in cancers, including lung cancer. Therefore, this study further explored miR-449a-mediated mechanism in lung cancer, mainly focusing on lys...

    Authors: Shan Hu, Peng Cao, Kangle Kong, Peng Han, Yu Deng, Fan Li and Bo Zhao
    Citation: Journal of Translational Medicine 2021 19:224
    Content type: Research Published on:

  21. Generally, cancer cells undergo metabolic reprogramming to adapt to energetic and biosynthetic requirements that support their uncontrolled proliferation. However, the mutual relationship between two critical ...

    Authors: Guoshu Bi, Yunyi Bian, Jiaqi Liang, Jiacheng Yin, Runmei Li, Mengnan Zhao, Yiwei Huang, Tao Lu, Cheng Zhan, Hong Fan and Qun Wang
    Citation: Journal of Translational Medicine 2021 19:219
    Content type: Research Published on:

  22. Eukaryotic translation initiation factor 6 (eIF6) has a crucial function in the maturation of 60S ribosomal subunits, and it controls the initiation of protein translation. Although emerging studies indicate t...

    Authors: Liping Sun, Shuguang Liu, Xiaopai Wang, Xuefeng Zheng, Ya Chen and Hong Shen
    Citation: Journal of Translational Medicine 2021 19:216
    Content type: Research Published on:

  23. As a significant cause of malignancy mortality, gastric carcinoma (GC) has been well documented to be an often-fatal diagnosis. Despite the limitations of effective therapy, immunotherapy has emerged as a prom...

    Authors: Qianmei Fu, Xiaohong Tan, Huaming Tang and Jijiang Liu
    Citation: Journal of Translational Medicine 2021 19:210
    Content type: Research Published on:

  24. Clear cell renal cell carcinoma (ccRCC) is the most common and aggressive type of renal malignancy. Methyltransferase like 13 (METTL13) functions as an oncogene in most of human cancers, but its function and m...

    Authors: Zhuonan Liu, Tianshui Sun, Chiyuan Piao, Zhe Zhang and Chuize Kong
    Citation: Journal of Translational Medicine 2021 19:209
    Content type: Research Published on:

  25. Tumor metastasis is the main cause of death of cancer patients, and cancer stem cells (CSCs) is the basis of tumor metastasis. However, systematic analysis of the stemness of prostate cancer cells is still not...

    Authors: Zao Dai and Ping Liu
    Citation: Journal of Translational Medicine 2021 19:206
    Content type: Research Published on:

  26. Lung cancer is one of the most widely spread cancers in the world and half of the non-small cell lung cancers are lung adenocarcinoma (LUAD). Although there were several drugs been approved for LUAD therapy, a...

    Authors: Guangyan Kan, Ziyang Wang, Chunjie Sheng, Chen Yao, Yizhi Mao and Shuai Chen
    Citation: Journal of Translational Medicine 2021 19:161
    Content type: Research Published on:

  28. CKLF like MARVEL transmembrane domain containing 6 (CMTM6) has been associated with the development in many kinds of cancers. However, the roles of CMTM6 in hepatocellular carcinoma (HCC) are largely unknown. ...

    Authors: Xiaoting Huang, Leyang Xiang, Baiyao Wang, Jijie Hu, Chunshan Liu, Anbang Ren, Kunpeng Du, Gengtai Ye, Yingying Liang, Yunqiang Tang, Dinghua Yang and Yawei Yuan
    Citation: Journal of Translational Medicine 2021 19:120
    Content type: Research Published on:

  29. Glucose-regulating protein 78 (GRP78) is a molecular chaperone in the endoplasmic reticulum (ER) that promotes folding and assembly of proteins, controls the quality of proteins, and regulates ER stress signal...

    Authors: Shengkai Xia, Wenzhe Duan, Wenwen Liu, Xinri Zhang and Qi Wang
    Citation: Journal of Translational Medicine 2021 19:118
    Content type: Review Published on:

  30. Bladder cancer (BCa) is a common malignancy characterized by high heterogeneity, yet the current treatment modalities are limited. The aim of the present investigation was to unravel the functional role of Kar...

    Authors: Fanchang Zeng, Liumei Luo, Daoyuan Li, Juncheng Guo and Min Guo
    Citation: Journal of Translational Medicine 2021 19:112
    Content type: Research Published on:

  31. Ovarian cancer (OV) is the deadliest gynecological cancer. Transmembrane protein 119 (TMEM119) has been reported as oncogene in several human cancers. However, the function of TMEM119 in OV is still poorly known.

    Authors: Tianshui Sun, Fangfang Bi, Zhuonan Liu and Qing Yang
    Citation: Journal of Translational Medicine 2021 19:111
    Content type: Research Published on:

  32. As a significant cause of cancer deaths worldwide, breast cancer continues to be a troublesome malignancy. Long non-coding RNAs (lncRNAs) have been implicated in the development of breast cancer. Abnormal meth...

    Authors: Aixia Hu, Fan Hong, Daohong Li, Yuwei Jin, Lingfei Kon, Ziguang Xu, Hui He and Qi Xie
    Citation: Journal of Translational Medicine 2021 19:95
    Content type: Research Published on:

  33. Nasopharyngeal carcinoma (NPC) is one of the most common malignancy in head and neck. With the development of treatments, the prognosis has improved these years, but metastasis is still the main cause of treat...

    Authors: Hui Tian, Si Shi, Bo You, Qicheng Zhang, Miao Gu and Yiwen You
    Citation: Journal of Translational Medicine 2021 19:77
    Content type: Research Published on:

  34. Studies of molecular mechanisms underlying tumor cell signaling highlighted a critical role for kinases in carcinogenesis and cancer progression. To this regard, protein kinases regulates a number of critical ...

    Authors: Francesca Benedetti, Sabrina Curreli, Robert C. Gallo and Davide Zella
    Citation: Journal of Translational Medicine 2021 19:60
    Content type: Research Published on:

  35. Colorectal cancer (CRC) is a common malignant tumor globally. Meanwhile, LINC01116 has been proposed as risk factor for various tumors, including CRC. But the regulation of LINC01116 in CRC required more valid...

    Authors: Weijie Liang, Jie Wu and Xinguang Qiu
    Citation: Journal of Translational Medicine 2021 19:45
    Content type: Research Published on:

  36. Non-small cell lung cancer (NSCLC) is a common type of lung cancer. Extracellular vehicles (EVs) are nano-sized particles containing proteins, lipids, and miRNAs secreted by various cells, which play important...

    Authors: Liming Gao, Qi Tian, Tong Wu, Shanshan Shi, Xiaobo Yin, Lijie Liu, Lei Zheng, Ping Wang, Yaling Tian and Shufeng Xu
    Citation: Journal of Translational Medicine 2021 19:37
    Content type: Research Published on:

  37. The ability of tumor cells to spread from their origin place and form secondary tumor foci is determined by the epithelial–mesenchymal transition process. In epithelial tumors such as prostate cancer (PCa), th...

    Authors: Martyna Parol, Arkadiusz Gzil, Magdalena Bodnar and Dariusz Grzanka
    Citation: Journal of Translational Medicine 2021 19:28
    Content type: Review Published on:

  40. Driver genes of GBM may be crucial for the onset of isocitrate dehydrogenase (IDH)-wildtype (WT) glioblastoma (GBM). However, it is still unknown whether the genes are expressed in the identical cluster of cells....

    Authors: Seon-Jin Yoon, Hye Young Son, Jin-Kyoung Shim, Ju Hyung Moon, Eui-Hyun Kim, Jong Hee Chang, Wan Yee Teo, Se Hoon Kim, Sahng Wook Park, Yong-Min Huh and Seok-Gu Kang
    Citation: Journal of Translational Medicine 2020 18:482
    Content type: Research Published on:

  41. Platelet derived growth factor receptor alpha (PDGFRα) has been considered as a relevant factor in tumor proliferation, angiogenesis and metastatic dissemination. It was a target of tyrosine kinase (TK) inhibi...

    Authors: Nadia Ben Jemii, Haifa Tounsi-Kettiti, Hamza Yaiche, Najla Mezghanni, Amira Jaballah Gabteni, Emna Fehri, Chayma Ben Fayala, Sonia Abdelhak and Samir Boubaker
    Citation: Journal of Translational Medicine 2020 18:440
    Content type: Research Published on:

  42. Cancer stem cells (CSCs) play an important role in drug resistance, recurrence, and metastasis of tumors. Considering the heterogeneity of tumors, this study aimed to explore the key genes regulating stem cell...

    Authors: Rui Guo, Aining Chu and Yuehua Gong
    Citation: Journal of Translational Medicine 2020 18:418
    Content type: Research Published on:

  43. Molecular classification has laid the framework for exploring glioma biology and treatment strategies. Pro-neural to mesenchymal transition (PMT) of glioma is known to be associated with aggressive phenotypes,...

    Authors: Qingyu Liang, Gefei Guan, Xue Li, Chunmi Wei, Jianqi Wu, Peng Cheng, Anhua Wu and Wen Cheng
    Citation: Journal of Translational Medicine 2020 18:378
    Content type: Research Published on:

Journal of Translational Medicine

ISSN: 1479-5876

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