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Translational Cancer Biology

Section edited by Cristina Maccalli

This section aims to provide a platform for the communication and dissemination of advances in cancer biology and their translational applications. Studies considered for publication include those dissecting the mechanisms of transformation, progression and metastatization, the biology of cancer stem cells and their immunological properties, the mechanisms undergoing the epithelial-to mesenchymal (EMT) transition and tumor dormancy, their relationship with immune functions and the mechanisms undergoing cancer resistance to therapies. 

This section is also dedicated to those investigations dedicated to the translational aspects and the development of novel therapies related to the aforementioned themes and the identification of patient’s responsiveness and outcome to therapies.

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  1. Epithelial ovarian cancer is the leading cause of death from gynecologic cancer, in which serous ovarian carcinoma (SOC) is the most common histological subtype. Although PARP inhibitors (PARPi) and antiangiog...

    Authors: Xiaohui Yang, Minying Zheng, Yidi Ning, Jie Sun, Yongjun Yu and Shiwu Zhang
    Citation: Journal of Translational Medicine 2023 21:456
    Content type: Research Published on:

  2. USP51 is a deubiquitinase (DUB), that is involved in diverse cellular processes. Accumulating evidence has demonstrated that USP51 contributes to cancer development. However, its impact on non-small cell lung ...

    Authors: Jin Chen, Zhongqiu Wu, Wenyi Deng, Minying Tang, Lvying Wu, Na Lin, Liuyan Chen, Yunfeng Fu, Min Zhao, Changguo Chen and Wenting Li
    Citation: Journal of Translational Medicine 2023 21:453
    Content type: Research Published on:

  3. Aberrant ubiquitin-proteasome system (UPS) triggers various disorders of biological events and contributes to progression of tumorigenesis. The tripartite motif containing 22 (TRIM22) was demonstrated to parti...

    Authors: Xiaoli Gu, Wei Min, Yibin Zeng, Ni Fan and Qihong Qian
    Citation: Journal of Translational Medicine 2023 21:443
    Content type: Research Published on:

  4. Intra-tumoral heterogeneity (ITH) is a distinguished hallmark of cancer, and cancer stem cells (CSCs) contribute to this malignant characteristic. Therefore, it is of great significance to investigate and even...

    Authors: Runtian Wang, Kun Xu, Qin Chen, Qin Hu, Jian Zhang and Xiaoxiang Guan
    Citation: Journal of Translational Medicine 2023 21:409
    Content type: Research Published on:

  5. Insulin like growth factor II mRNA binding protein 3 (IGF2BP3) is an RNA binding protein with multiple roles in regulation of gene expression at the post-transcriptional level and is implicated in tumorigenesi...

    Authors: Feifei Yang, Qiang Ma, Bo Huang, Xiaolin Wang, Xiaojuan Pan, Ting Yu, Lingyu Ran, Shan Jiang, Haiping Li, Ye Chen, Yuying Liu, Ce Liang, Junwu Ren, Yuying Zhang, Shimin Wang, Wei Li…
    Citation: Journal of Translational Medicine 2023 21:402
    Content type: Research Published on:

  6. Bone marrow metastasis (BMM) is underestimated in gastric cancer (GC). GC with BMM frequently complicate critical hematological abnormalities like diffused intravascular coagulation and microangiopathic hemoly...

    Authors: Caiqin Wang, Bo Xie, Shi Yin, Jianghua Cao, Junhao Huang, Longyang Jin, Ge Du, Xiaohui Zhai, Rongqin Zhang, Shanshan Li, Taiyuan Cao, Hongen Yu, Xinjuan Fan, Zuli Yang, Junsheng Peng, Jian Xiao…
    Citation: Journal of Translational Medicine 2023 21:399
    Content type: Research Published on:

  7. Ovarian cancer (OC) has high mortality and poor prognosis for lacking of specific biomarkers and typical clinical symptoms in the early stage. CEBPG is an important regulator in tumor development, yet it is un...

    Authors: Xiaoqian Zhang, Xiaocui Zheng, Xiang Ying, Weiwei Xie, Yujia Yin and Xipeng Wang
    Citation: Journal of Translational Medicine 2023 21:334
    Content type: Research Published on:

  8. Pancreatic ductal adenocarcinoma (PDAC) has a low survival, its incidence is rising and little therapeutic improvements are expected in the near future. It has been observed that Epithelial-to-Mesenchymal tran...

    Authors: Jos van Pelt, Bob Meeusen, Rita Derua, Liesbeth Guffens, Eric Van Cutsem, Veerle Janssens and Chris Verslype
    Citation: Journal of Translational Medicine 2023 21:317
    Content type: Research Published on:

  9. Gallbladder cancer (GBC) is the most prevalent and invasive biliary tract malignancy. As a GTPase-activating protein, Neurofibromin 1 (NF1) is a tumor suppressor that negatively regulates the RAS signaling pat...

    Authors: Lingxiao Zhang, Lin Jiang, Ling Zeng, Zhaohui Jin, Xuanjia Dong, Yuhan Zhang, Litian Chen, Yijun Shu, Yingbin Liu and Ying Huang
    Citation: Journal of Translational Medicine 2023 21:306
    Content type: Research Published on:

  10. Metastatic prostate cancer (mPCa) has a poor prognosis with limited treatment options. The high mobility of tumor cells is the key driving characteristic of metastasis. However, the mechanism is complex and fa...

    Authors: Zean Li, Yiran Tao, Ze Gao, Shirong Peng, Yiming Lai, Kaiwen Li, Xu Chen and Hai Huang
    Citation: Journal of Translational Medicine 2023 21:303
    Content type: Research Published on:

  11. Epithelial-to-mesenchymal transition (EMT) and cancer stem-like cells (CSLCs) play crucial role in tumor metastasis and drug-resistance. Disheveled3 (DVL3) is involved in malignant behaviors of cancer. However...

    Authors: Zhengguang Li, Zhirong Yang, Wei Liu, Wanglong Zhu, Lan Yin, Zhenyu Han, Yu Xian, Jie Wen, Hualong Tang, Xinyue Lin, Yuhan Yang, Jingyi Wang and Kun Zhang
    Citation: Journal of Translational Medicine 2023 21:302
    Content type: Research Published on:

  12. Osteosarcoma is a type of bone cancer that predominantly affects young individuals, including children and adolescents. The disease progresses through heterogeneous genetic alterations, and patients often deve...

    Authors: Ravi Chauhan, Ashna Gupta, Lakshay Malhotra, Ajaz A. Bhat, Raj K. Pandita, Tariq Masoodi, Gunjan Dagar, Hana Q. Sadida, Sara K. Al-Marzooqi, Atul Batra, Sameer Bakhshi, Mehar Chand Sharma, Pranay Tanwar, Shah Alam Khan, Ethayathulla Abdul Samath, Shahab Uddin…
    Citation: Journal of Translational Medicine 2023 21:286
    Content type: Research Published on:

  13. The primary cilia (PC) is a microtubule-based and nonmotile organelle which protrudes from the surface of almost all mammalian cells. At present, PC has been found to be a deficiency or loss in multiple cancer...

    Authors: Jingxian Li, Yuanjiong Qi, Bo Li, Yan Liu, Kuo Yang, Zhihong Zhang, Jianqiang Zhu and E. Du
    Citation: Journal of Translational Medicine 2023 21:281
    Content type: Research Published on:

  14. Oral squamous cell carcinoma (OSCC), an HPV-negative head and neck cancer, frequently metastasizes to the regional lymph nodes but only occasionally beyond. Initial phases of metastasis are associated with an ...

    Authors: Kai Horny, Christoph Sproll, Lukas Peiffer, Frauke Furtmann, Patricia Gerhardt, Jan Gravemeyer, Nikolas H. Stoecklein, Ivelina Spassova and Jürgen C. Becker
    Citation: Journal of Translational Medicine 2023 21:267
    Content type: Research Published on:

    The Correction to this article has been published in Journal of Translational Medicine 2024 22:277

  15. Metastasis, the leading cause of cancer-related death in patients diagnosed with ovarian cancer (OC), is a complex process that involves multiple biological effects. With the continuous development of sequenci...

    Authors: Jiahao Guo, Xiaoyang Han, Jie Li, Zhefeng Li, Junjie Yi, Yan Gao, Xiaoting Zhao and Wentao Yue
    Citation: Journal of Translational Medicine 2023 21:254
    Content type: Research Published on:

  16. Cancer-associated fibroblasts (CAFs), an important component of the tumor microenvironment (TME), play crucial roles in tumor stemness. It has been shown in various cancer studies that stanniocalcin-1 (STC1) i...

    Authors: Shuya Bai, Yuchong Zhao, Wei Chen, Wang Peng, Yun Wang, Si Xiong, Aruna, Yanling Li, Yilei Yang, Shiru Chen, Bin Cheng and Ronghua Wang
    Citation: Journal of Translational Medicine 2023 21:236
    Content type: Research Published on:

  17. The prognosis of pancreatic cancer patients remains relatively poor. Although some patients would receive surgical resection, distant metastasis frequently occurs within one year. Epithelial-mesenchymal transi...

    Authors: Yuanyang Wang, Cheng Qin, Bangbo Zhao, Zeru Li, Tianyu Li, Xiaoying Yang, Yutong Zhao and Weibin Wang
    Citation: Journal of Translational Medicine 2023 21:201
    Content type: Research Published on:

  18. The interaction between the tumor-microenvironment (TME) and the cancer cells has emerged as a key player in colorectal cancer (CRC) metastasis. A small proportion of CRC cells which undergo epithelial-mesench...

    Authors: Jinsen Zheng, Rongzhang Dou, Xinyao Zhang, Bo Zhong, Chenggang Fang, Qian Xu, Ziyang Di, Sihao Huang, Zaihuan Lin, Jialin Song, Shuyi Wang and Bin Xiong
    Citation: Journal of Translational Medicine 2023 21:153
    Content type: Research Published on:

  19. Cancer-testis antigens (CTAs) are often expressed in tumor and testicular tissues but not in other normal tissues. To date, there has been no comprehensive study of the expression and clinical significance of ...

    Authors: Yu Miao, Yosuke Konno, Baojin Wang, Lin Zhu, Tianyue Zhai, Kei Ihira, Noriko Kobayashi, Hidemichi Watari, Xin Jin, Junming Yue, Peixin Dong and Mingyan Fang
    Citation: Journal of Translational Medicine 2023 21:151
    Content type: Research Published on:

  20. Histone deacetylases (HDAC) contribute to oncogenic program, pointing to their inhibitors as a potential strategy against cancers. We, thus, studied the mechanism of HDAC inhibitor ITF2357 in resistance of mut...

    Authors: Jian Cui, Fei Xu, Wei Bai, Tiantian Zhao, Junbo Hong and Wei Zuo
    Citation: Journal of Translational Medicine 2023 21:125
    Content type: Research Published on:

  21. Metastasis is the predominant cause of mortality in patients with breast cancer. Long noncoding RNAs (lncRNAs) have been shown to drive important phenotypes in tumors, including invasion and metastasis. Howeve...

    Authors: Rong Guo, Yonghui Su, Qi Zhang, Bingqiu Xiu, Sheng Huang, Weiru Chi, Liyi Zhang, Lun Li, Jianjing Hou, Jia Wang, Jiajian Chen, Yayun Chi, Jingyan Xue and Jiong Wu
    Citation: Journal of Translational Medicine 2023 21:120
    Content type: Research Published on:

  22. The role of microRNA (miRNA) in modulating the function of cancer stem cells through diverse signaling pathway has been evidenced. We here identified a role of microRNA (miRNA) family, specifically miR-148/152...

    Authors: Xiaoying Li, Lin Li and Jiangying Wu
    Citation: Journal of Translational Medicine 2023 21:105
    Content type: Research Published on:

  23. Sirtuin 3 (Sirt3) is a controversial regulator of carcinogenesis. It residents in the mitochondria and gradually decays during aging. In this study, we tried to investigate the role of Sirt3 in carcinogenesis ...

    Authors: Liyi Wu, Xinyi Yan, Ruibo Sun, Ye Ma, Wanyu Yao, Baogui Gao, Qingyuan Zhang, Junxiong You, Hao Wang, Qinrui Han and Xuegang Sun
    Citation: Journal of Translational Medicine 2023 21:81
    Content type: Research Published on:

  24. Clear cell renal cell carcinoma (ccRCC) is a major worldwide health problem due to its high prevalence and mortality rate. A disintegrin and metalloproteinase 12 (ADAM12) is aberrantly expressed in various can...

    Authors: Jinming Xu, Yan Wang, Jiahao Jiang, Cong Yin and Bentao Shi
    Citation: Journal of Translational Medicine 2023 21:56
    Content type: Research Published on:

  25. Deterioration of normal intestinal epithelial cells is crucial for colorectal tumorigenesis. However, the process of epithelial cell deterioration and molecular networks that contribute to this process remain ...

    Authors: Xiaoqi Huang, Chongyin Han, Jiayuan Zhong, Jiaqi Hu, Yabin Jin, Qinqin Zhang, Wei Luo, Rui Liu and Fei Ling
    Citation: Journal of Translational Medicine 2023 21:45
    Content type: Research Published on:

  26. Esophageal squamous cell carcinoma (ESCC) is a deadly gastrointestinal malignancy, and chemotherapy resistance is a key factor leading to its poor prognosis. M2 tumor-associated macrophages (M2-TAMs) may be an...

    Authors: Kaige Yang, Yufang Xie, Lele Xue, Fanping Li, Chenghua Luo, Weihua Liang, Haijun Zhang, Ya Li, Yilin Ren, Mengmeng Zhao, Weinan Wang, Jia Liu, Xihua Shen, Wenhu Zhou, Jing Fei, Weigang Chen…
    Citation: Journal of Translational Medicine 2023 21:26
    Content type: Research Published on:

  27. Gastric cancer (GC) is the fifth most common cancer and the third most common cause of cancer death worldwide. Plant homeodomain (PHD)-finger domain protein PHF5A has been demonstrated to play a promoting role...

    Authors: Zhandong Zhang, Liangqun Peng, Wei Yang, Baodong Li, Yawei Hua and Suxia Luo
    Citation: Journal of Translational Medicine 2023 21:5
    Content type: Research Published on:

  28. Solid tumors are stiffer than their surrounding normal tissues; however, their interior stiffness is not uniform. Under certain conditions, cancer cells can acquire stem-like phenotypes. However, it remains un...

    Authors: Jiayun Wei, Jia Yao, Chendong Yang, Yongcui Mao, Dan Zhu, Ye Xie, Pinyan Liu, Mengchao Yan, Longfei Ren, Yan Lin, Qiuxia Zheng and Xun Li
    Citation: Journal of Translational Medicine 2022 20:555
    Content type: Research Published on:

  29. The tumour microenvironment and cirrhotic liver are excellent sources of cancer-associated fibroblasts (CAFs), which participate in carcinogenesis. Thus, it is important to clarify the crosstalk between CAFs a...

    Authors: Jungang Zhao, Rizhao Li, Jiacheng Li, Ziyan Chen, Zixia Lin, Baofu Zhang, Liming Deng, Gang Chen and Yi Wang
    Citation: Journal of Translational Medicine 2022 20:520
    Content type: Research Published on:

  30. Pancreatic cancer (PC) is a highly malignant tumor which threatens human’s health. Long non-coding RNAs (lncRNAs) are implicated in many cancers, including PC, but their mechanisms in PC have not yet been enti...

    Authors: Dandan Yu, Zhigang Zhao, Li Wang, Shishi Qiao, Zhen Yang, Qiang Wen and Guanghui Zhu
    Citation: Journal of Translational Medicine 2022 20:511
    Content type: Research Published on:

  31. Hepatocellular carcinoma (HCC) is one of the most common and malignant tumors in the digestive tract. Tumor Suppressor Candidate 3 (TUSC3) is one subunit of the endoplasmic reticulum Oligosaccharyl transferase...

    Authors: Ruxia Deng, Xiansheng Lu, Chang Hong, Rui Cai, Ping Wang, Le Xiong, Xiaoyu Wang, Qiaoyu Chen and Jie Lin
    Citation: Journal of Translational Medicine 2022 20:485
    Content type: Research Published on:

  32. Metastasis is the primary cause of cancer-related mortality. Metastasis involves a complex multistep process during which individual tumor cells spread primarily through destruction of the endothelial barrier,...

    Authors: Guoxin Zhang, Mengyuan Li, Dandan Zhou, Xingjiu Yang, Wenlong Zhang and Ran Gao
    Citation: Journal of Translational Medicine 2022 20:446
    Content type: Research Published on:

  33. Adrenocortical carcinoma (ACC) is an extremely rare, aggressive tumor with few effective therapeutic options or drugs. Mitotane (Mtn), which is the only authorized therapeutic drug, came out in 1970 and is sti...

    Authors: Liwen Ren, Yihui Yang, Wan Li, Xiangjin Zheng, Jinyi Liu, Sha Li, Hong Yang, Yizhi Zhang, Binbin Ge, Sen Zhang, Weiqi Fu, Dexin Dong, Guanhua Du and Jinhua Wang
    Citation: Journal of Translational Medicine 2022 20:444
    Content type: Research Published on:

  34. Gallbladder cancer (GBC) is a highly aggressive malignant cancer in the biliary system with poor prognosis. XPO1 (chromosome region maintenance 1 or CRM1) mediates the nuclear export of several proteins, mainl...

    Authors: Cheng Zhao, Zi-yi Yang, Jian Zhang, Ou Li, Shi-lei Liu, Chen Cai, Yi-jun Shu, Li-jia Pan, Wei Gong and Ping Dong
    Citation: Journal of Translational Medicine 2022 20:434
    Content type: Research Published on:

  35. Esophageal squamous cell carcinoma (ESCC) is one of the most severe cancers and is characterized by chemotherapy resistance and poor prognosis associated with epithelial-mesenchymal transition (EMT). In a prev...

    Authors: Yuto Kubo, Koji Tanaka, Yasunori Masuike, Tsuyoshi Takahashi, Kotaro Yamashita, Tomoki Makino, Takuro Saito, Kazuyoshi Yamamoto, Tomoyuki Tsujimoto, Takashi Harino, Yukinori Kurokawa, Makoto Yamasaki, Kiyokazu Nakajima, Hidetoshi Eguchi and Yuichiro Doki
    Citation: Journal of Translational Medicine 2022 20:383
    Content type: Research Published on:

  36. Osteosarcoma is one of the most malignant tumors, and it occurs mostly in children and adolescents. Currently, surgery and chemotherapy are the main treatments. The recurrence rate is high and the prognosis is...

    Authors: Wenhao Chen, Yuxiang Lin, Meichen Jiang, Qingshui Wang and Qiang Shu
    Citation: Journal of Translational Medicine 2022 20:355
    Content type: Research Published on:

  37. PolyC-RNA-binding protein 1 (PCBP1) functions as a tumour suppressor and RNA regulator that is downregulated in human cancers. Here, we aimed to reveal the biological function of PCBP1 in lung adenocarcinoma (...

    Authors: Yujia Zheng, Zheng Zhou, Ran Wei, Chu Xiao, Hao Zhang, Tao Fan, Bo Zheng, Chunxiang Li and Jie He
    Citation: Journal of Translational Medicine 2022 20:343
    Content type: Research Published on:

  38. Glutamine is the most abundant amino acid in the body and plays a vital role in colorectal cancer (CRC) cell metabolism. However, limited studies have investigated the clinical and prognostic significance of p...

    Authors: Hongyan Sun, Chuan Zhang, Yang Zheng, Chenlu Liu, Xue Wang and Xianling Cong
    Citation: Journal of Translational Medicine 2022 20:330
    Content type: Research Published on:

  39. Recent studies have shown that the fox family plays a vital role in tumorigenesis and progression. Forkhead Box S1 (FOXS1), as a newly identified subfamily of the FOX family, is overexpressed in certain types ...

    Authors: Liang Zhang, Chuan-fu Ren, Zhi Yang, Long-bo Gong, Chao Wang, Min Feng and Wen-xian Guan
    Citation: Journal of Translational Medicine 2022 20:327
    Content type: Research Published on:

  40. Circular RNAs (circRNAs) belong to a novel class of noncoding RNA that gained more attention in human cancer pathogenesis. The role of circRNA in esophageal squamous cell carcinoma (ESCC) is largely unclear. P...

    Authors: Pei Xu, Lei Wang, Qingtao Liu, Pengkai Gao, Fengqing Hu, Xiao Xie, Lianyong Jiang, Rui Bi, Fangbao Ding, Qi Yang and Haibo Xiao
    Citation: Journal of Translational Medicine 2022 20:318
    Content type: Research Published on:

  41. Acute Myeloid Leukaemia (AML) is a haematological malignancy showing a hypervariable landscape of clinical outcomes and phenotypic differences, explainable by heterogeneity at the cellular and molecular level....

    Authors: Gabriele Lo Iudice, Eleonora De Bellis, Arianna Savi, Luca Guarnera, Alice Massacci, Francesca De Nicola, Frauke Goeman, Tiziana Ottone, Mariadomenica Divona, Matteo Pallocca, Maurizio Fanciulli, Maria Teresa Voso and Gennaro Ciliberto
    Citation: Journal of Translational Medicine 2022 20:311
    Content type: Research Published on:

  43. Tumour-derived exosomes have recently been shown to participate in the formation and progression of different cancer processes, including tumour microenvironment remodelling, angiogenesis, invasion, metastasis...

    Authors: Qiang Song, Hao Yu, Yidong Cheng, Jie Han, Kai Li, Juntao Zhuang, Qiang Lv, Xiao Yang and Haiwei Yang
    Citation: Journal of Translational Medicine 2022 20:308
    Content type: Research Published on:

  44. Colorectal cancer (CRC) is a common malignant tumor with a high risk of metastasis. Long non-coding RNAs (lncRNAs) have been reported to be implicated in cancer progression via regulating its nearby gene. Here...

    Authors: Yuliang Pan, Yuxing Zhu, Jun Zhang, Long Jin and Peiguo Cao
    Citation: Journal of Translational Medicine 2022 20:287
    Content type: Research Published on:

  45. Previous studies have indicated that chronic emotional stressors likely participate in the occurrence of cancers. However, direct evidence connecting stress and colorectal cancer development remains almost com...

    Authors: Zili Zhou, Yan Shu, Haijun Bao, Shengbo Han, Zhengyi Liu, Ning Zhao, Wenzheng Yuan, Chenxing Jian and Xiaogang Shu
    Citation: Journal of Translational Medicine 2022 20:262
    Content type: Research Published on:

  46. Lymphatic metastasis was an independent prognostic risk factor for hypopharyngeal carcinoma and was the main cause of treatment failure. The purpose of this study was to screen the differential genes and inves...

    Authors: Yanshi Li, Min Pan, Tao Lu, Dan Yu, Chuan Liu, Zhihai Wang and Guohua Hu
    Citation: Journal of Translational Medicine 2022 20:255
    Content type: Research Published on:

  47. An increasing number of studies have demonstrated that long non-coding RNAs (lncRNAs) serve as key regulators in tumor development and progression. However, only a few lncRNAs have been functionally characteri...

    Authors: Jixu Wang, Futao Hou, Lusheng Tang, Ke Xiao, Tengfei Yang, Zhiqiang Wang and Gu Liu
    Citation: Journal of Translational Medicine 2022 20:220
    Content type: Research Published on:

  48. NOS1 expression predicts poor prognosis in patients with melanoma. However, the molecular function of NOS1 in the type I IFN response and immune escape of melanoma is still unknown.

    Authors: Xi Chen, Zhiwei Zou, Qianli Wang, Wenwen Gao, Sisi Zeng, Shuangyan Ye, Pengfei Xu, Mengqiu Huang, Keyi Li, Jianping Chen, Zhuo Zhong, Qianbing Zhang, Bingtao Hao and Qiuzhen Liu
    Citation: Journal of Translational Medicine 2022 20:205
    Content type: Research Published on:

  49. Knowledge of the role of CYP2E1 in hepatocarcinogenesis is largely based on epidemiological and animal studies, with a primary focus on the role of CYP2E1 in metabolic activation of procarcinogens. Few studies...

    Authors: Lili Zhu, Xiaobei Yang, Jingyu Feng, Jian Mao, Qidong Zhang, Mengru He, Yang Mi, Yingwu Mei, Ge Jin and Haifeng Zhang
    Citation: Journal of Translational Medicine 2022 20:194
    Content type: Research Published on:

  50. Triosephosphate isomerase 1 (TPI1), as a key glycolytic enzyme, is upregulated in multiple cancers. However, expression profile and regulatory mechanism of TPI1 in breast cancer (BRCA) remain mysterious.

    Authors: Xiaoying Jin, Dandan Wang, Mengxia Lei, Yan Guo, Yuqing Cui, Fengzhi Chen, Weiling Sun and Xuesong Chen
    Citation: Journal of Translational Medicine 2022 20:191
    Content type: Research Published on:

Journal of Translational Medicine

ISSN: 1479-5876

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