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Translational Signaling and System Biology

Section edited by Marcello Maggiolini

© © selvanegra / Getty Images / iStock

The Translational Signaling and System Biology section aims to uncover pivotal transduction signaling involved in pathophysiological processes toward a translational impact on the discovery of novel targets and therapeutics. 

The section welcomes research and review articles providing new mechanistic insights on a broad range of fields such as cancer, cardiovascular biology, neuroscience, metabolism, inflammation, immunology, microbiology, drug action also through new formulations and delivery methods, novel cellular and animal models, computational and systems biology, innovative laboratory concepts fostering translational research from the bench to the bedside.

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  1. Prostate cancer (PCa) is a prevalent malignant disease affecting a significant number of males globally. Elevated expression of the Bloom’s syndrome protein (BLM) helicase has emerged as a promising cancer bio...

    Authors: Mengqiu Huang, Lin Chen, Yingchu Guo, Yong Ruan and Houqiang Xu
    Citation: Journal of Translational Medicine 2023 21:445
    Content type: Research Published on:

  2. Cervical cancer (CC) has poor prognosis and high mortality rate for its metastasis during the disease progression. Epithelial-mesenchymal transition (EMT) and anoikis are initial and pivotal steps during the m...

    Authors: Mengwen Zhang, Xiaoling Hong, Ning Ma, Zhentong Wei, Xinxin Ci and Songling Zhang
    Citation: Journal of Translational Medicine 2023 21:433
    Content type: Research Published on:

  3. RP11-296E3.2 is a novel long noncoding RNA (lncRNA) associated with colorectal cancer (CRC) metastasis, that was reported in our previous clinical studies. However, the mechanisms of RP11-296E3.2 in colorectal...

    Authors: Qian Shi, Ying He, Shouyu He, Jingjing Li, Ji Xia, Tianwei Chen, Lixia Huo, Yuhang Ling, Qinchen Liu, Wei Zang, Qiang Wang, Chengwu Tang and Xiang Wang
    Citation: Journal of Translational Medicine 2023 21:418
    Content type: Research Published on:

  4. In recent decades, the incidence of thyroid cancer keeps growing at a shocking rate, which has aroused increasing concerns worldwide. Autophagy is a fundamental and ubiquitous biological event conserved in mam...

    Authors: Yu-Bo Shi, Shu-Yuan Chen and Ren-Bin Liu
    Citation: Journal of Translational Medicine 2023 21:413
    Content type: Review Published on:

  5. Accumulating data indicate that N6-methyladenosine (m6A) RNA methylation and lncRNA deregulation act crucial roles in cancer progression. Heterogeneous nuclear ribonucleoprotein A2B1 (HNRNPA2B1) as an m6A “reader...

    Authors: Ke Li, Quan Gong, Xu-Dong Xiang, Gang Guo, Jia Liu, Li Zhao, Jun Li, Nan Chen, Heng Li, Li-Juan Zhang, Chun-Yan Zhou, Zhi-Yong Wang and Li Zhuang
    Citation: Journal of Translational Medicine 2023 21:382
    Content type: Research Published on:

  6. The transcription factor family activator protein 2 (TFAP2) is vital for regulating both embryonic and oncogenic development. The TFAP2 family consists of five DNA-binding proteins, including TFAP2A, TFAP2B, T...

    Authors: Chen Jin, Yuxiao Luo, Zhu Liang, Xi Li, Damian Kołat, Linyong Zhao and Weixi Xiong
    Citation: Journal of Translational Medicine 2023 21:371
    Content type: Review Published on:

  7. Hepatocellular carcinoma (HCC) is the leading cause of cancer-related death in people, and a common primary liver cancer. Lacking early diagnosis and a high recurrence rate after surgical resection, systemic t...

    Authors: Yuan Fang, XiaoLi Zhang, HanFei Huang and Zhong Zeng
    Citation: Journal of Translational Medicine 2023 21:369
    Content type: Review Published on:

  8. Circular RNAs (circRNAs) are known to play a crucial role in a variety of malignancies. However, the precise role of circRNAs in cervical squamous cell carcinoma (CSCC) remains largely unknown.

    Authors: Wei Wang, Haixia Luo, Jingjing Chang, Xin Yang, Xiu Zhang, Qingmei Zhang, Yuanxing Li, Yueyang Zhao, Jianbing Liu, Binbin Zou and Min Hao
    Citation: Journal of Translational Medicine 2023 21:356
    Content type: Research Published on:

  9. Pronectins™ are a new class of fibronectin-3-domain 14th-derived (14Fn3) antibody mimics that can be engineered as bispecific T cell engager (BTCE) to redirect immune effector cells against cancer. We describe...

    Authors: Caterina Riillo, Nicoletta Polerà, Maria Teresa Di Martino, Giada Juli, Craig A. Hokanson, Tatjana Odineca, Stefania Signorelli, Katia Grillone, Serena Ascrizzi, Antonia Mancuso, Nicoletta Staropoli, Basilio Caparello, Maria Cerra, Giuseppe Nisticò, Pierosandro Tagliaferri, Roberto Crea…
    Citation: Journal of Translational Medicine 2023 21:301
    Content type: Research Published on:

  10. Circular RNAs (circRNAs) may regulate the onset and progression of human malignancies by competitively binding to microRNA (miRNA) sponges, thus regulating the downstream genes. However, aberrant circRNA expre...

    Authors: Huan Feng, Zhiyao Deng, Wei Peng, Xian Wei, Jihong Liu and Tao Wang
    Citation: Journal of Translational Medicine 2023 21:288
    Content type: Research Published on:

  11. Both dysregulation of mechanistic target of rapamycin (mTOR) signalling and DNA methylation patterns have been shown to be closely associated with tumor progression and serve as promising targets for hepatocel...

    Authors: Mengke Chen, Yi Fang, Meinong Liang, Ning Zhang, Xinyue Zhang, Lixia Xu, Xuxin Ren, Qingfeng Zhang, Yufeng Zhou, Sui Peng, Jun Yu, Judeng Zeng and Xiaoxing Li
    Citation: Journal of Translational Medicine 2023 21:276
    Content type: Research Published on:

  12. The incidence of obesity, a known risk factor for several metabolic and chronic diseases, including numerous malignancies, has risen sharply in the world. Various clinical studies demonstrate that excessive Bo...

    Authors: Ines Barone, Luca Gelsomino, Felice Maria Accattatis, Francesca Giordano, Balazs Gyorffy, Salvatore Panza, Mario Giuliano, Bianca Maria Veneziani, Grazia Arpino, Carmine De Angelis, Pietro De Placido, Daniela Bonofiglio, Sebastiano Andò, Cinzia Giordano and Stefania Catalano
    Citation: Journal of Translational Medicine 2023 21:232
    Content type: Research Published on:

  13. T cell activation and programming from their naïve/resting state, characterized by widespread modifications in chromatin accessibility triggering extensive changes in transcriptional programs, is orchestrated ...

    Authors: Erika Di Zazzo, Monica Rienzo, Amelia Casamassimi, Caterina De Rosa, Nicola Medici, Patrizia Gazzerro, Maurizio Bifulco and Ciro Abbondanza
    Citation: Journal of Translational Medicine 2023 21:217
    Content type: Research Published on:

  14. Gut microbiota modulation has been demonstrated to be effective in protecting patients against detrimental effects of anti-cancer therapies, as well as to improve the efficacy of certain anti-cancer treatments...

    Authors: Rossella Salemi, Silvia Vivarelli, Daria Ricci, Marina Scillato, Maria Santagati, Giuseppe Gattuso, Luca Falzone and Massimo Libra
    Citation: Journal of Translational Medicine 2023 21:195
    Content type: Research Published on:

  15. Breast cancer (BC) is a common malignant tumor in women worldwide. Circular RNA (circRNA) has been proven to play a critical role in BC progression. However, the exact biological functions and underlying mecha...

    Authors: Bin Wang, Hang Chen, Yumei Deng, Hong Chen, Lei Xing, Yuping Guo, Min Wang and Junxia Chen
    Citation: Journal of Translational Medicine 2023 21:186
    Content type: Research Published on:

  16. Breast cancer is the second leading cause of death among women after lung cancer. Despite the improvement in prevention and in therapy, breast cancer still remains a threat, both for pre- and postmenopausal wo...

    Authors: Francesca Giordano, Alessandro Paolì, Martina Forastiero, Stefania Marsico, Francesca De Amicis, Mariangela Marrelli, Giuseppina Daniela Naimo, Loredana Mauro and Maria Luisa Panno
    Citation: Journal of Translational Medicine 2023 21:165
    Content type: Research Published on:

  17. Breast cancer (BC) is the second most common cancer and cause of death in women. In recent years many studies investigated the association of long non-coding RNAs (lncRNAs), as novel genetic factors, on BC ris...

    Authors: Morteza Gholami, Zeynab Nickhah Klashami, Pirooz Ebrahimi, Amir Ali Mahboobipour, Amir Salehi Farid, Aida Vahidi, Marziyeh Zoughi, Mojgan Asadi and Mahsa M. Amoli
    Citation: Journal of Translational Medicine 2023 21:155
    Content type: Review Published on:

  18. Liver metastasis is the leading cause of death in patients with colorectal cancer (CRC). Surgical resection of the liver metastases increases the incidence of long-term survival in patients with colorectal liv...

    Authors: Xiangdong Li, Ziyi Wang, Chenyu Jiao, Yu Zhang, Nan Xia, Wenjie Yu, Xuejiao Chen, Likalamu Pascalia Wikana, Yue Liu, Linfeng Sun, Minhao Chen, Yuhao Xiao, Yuhua Shi, Sheng Han and Liyong Pu
    Citation: Journal of Translational Medicine 2023 21:121
    Content type: Research Published on:

  19. Gastric cancer (GC) is the third-leading cause of cancer-associated mortalities globally. The deregulation of circular RNAs (circRNAs) and microRNAs (miRNAs or miRs) is widely implicated in the pathogenesis an...

    Authors: Jun You, Yinan Chen, Donghan Chen, Yongwen Li, Tinghao Wang, Jingtao Zhu, Qingqi Hong and Qiyuan Li
    Citation: Journal of Translational Medicine 2023 21:83
    Content type: Research Published on:

  20. Our previous study showed that fucosyltransferase 2 (Fut2) deficiency is closely related to colitis. Colitis increases the risk for the development of colorectal cancer (CRC). This study aimed to investigate t...

    Authors: Weijun Wang, Xuelian Tang, Caihan Duan, Shuxin Tian, Chaoqun Han, Wei Qian, Xin Jiang, Xiaohua Hou and Rong Lin
    Citation: Journal of Translational Medicine 2023 21:82
    Content type: Research Published on:

  21. Chronic inflammation is a well-known risk factor for the development of gastric cancer (GC). Nevertheless, the molecular mechanisms underlying inflammation-related GC progression are incompletely defined.

    Authors: Tingting Xu, Mengyan Xie, Xinming Jing, Huning Jiang, Xi Wu, Xinzhu Wang and Yongqian Shu
    Citation: Journal of Translational Medicine 2023 21:77
    Content type: Research Published on:

  22. Pancreatic ductal adenocarcinoma (PDAC) and prostate cancer (PCa) are among the most prevalent malignant tumors worldwide. There is now a comprehensive understanding of metabolic reprogramming as a hallmark of...

    Authors: Ugo Chianese, Chiara Papulino, Ahmad Ali, Fortunato Ciardiello, Salvatore Cappabianca, Lucia Altucci, Vincenzo Carafa and Rosaria Benedetti
    Citation: Journal of Translational Medicine 2023 21:32
    Content type: Research Published on:

  23. Circular RNAs (circRNAs) have been shown to be essential for the emergence and growth of different cancers. However, further research is required to validate the function of circRNA in glioblastoma (GBM).

    Authors: Yuhang Wang, Binbin Wang, Fengqi Zhou, Kun Lv, Xiupeng Xu and Wenping Cao
    Citation: Journal of Translational Medicine 2023 21:22
    Content type: Research Published on:

  24. The actin filament-associated protein (AFAP) family genes include AFAP1/AFAP-110, AFAP1L1 and AFAP1L2/XB130. Increasing evidence indicates these three AFAP family members participate in tumor progression, but ...

    Authors: Bo Sun, Bai Ding, Yu Chen, Chuang Peng and Xu Chen
    Citation: Journal of Translational Medicine 2023 21:18
    Content type: Research Published on:

  26. Clear cell renal cell carcinoma (ccRCC), the most common urological malignancy, has an unfavorable prognosis and an unknown mechanism of progression. Through survival analyses screening of The Cancer Genome At...

    Authors: Wenliang Ma, Xin Li, Lei Yang, Jun Pan, Yi Chen, Yanwen Lu, Xiang Dong, Dongmei Li and Weidong Gan
    Citation: Journal of Translational Medicine 2022 20:554
    Content type: Research Published on:

  27. MICAL1 is involved in the malignant processes of several types of cancer; however, the role of MICAL1 in pancreatic cancer (PC) has not been well-characterized. This study aimed to investigate the expression a...

    Authors: Kun Cai, Lu Deng, Dijie Zheng, Lin Li, Zhiwei He and Chao Yu
    Citation: Journal of Translational Medicine 2022 20:528
    Content type: Research Published on:

  28. DNA ligases are crucial for DNA repair and cell replication since they catalyze the final steps in which DNA breaks are joined. DNA Ligase III (LIG3) exerts a pivotal role in Alternative-Non-Homologous End Joi...

    Authors: Daniele Caracciolo, Giada Juli, Caterina Riillo, Adriana Coricello, Francesca Vasile, Sara Pollastri, Roberta Rocca, Francesca Scionti, Nicoletta Polerà, Katia Grillone, Mariamena Arbitrio, Nicoletta Staropoli, Basilio Caparello, Domenico Britti, Giovanni Loprete, Giosuè Costa…
    Citation: Journal of Translational Medicine 2022 20:482
    Content type: Research Published on:

  29. Long non-coding RNAs (lncRNAs) are essential regulators of tumorigenesis and the development of colorectal cancer (CRC). Here, we aimed to investigate the role of lncRNA GAS6-AS1 in CRC and its potential mecha...

    Authors: Qing Chen, Lin Zhou, De Ma, Juan Hou, Yuxin Lin, Jie Wu and Min Tao
    Citation: Journal of Translational Medicine 2022 20:356
    Content type: Research Published on:

  30. NCAPG, non-SMC subunit in the concentrate I complex, might promote the proliferation of hepatocellular carcinoma (HCC), but the mechanism is unclear. The aim of this study was to explore how NCAPG affects PTEN...

    Authors: Rongguiyi Zhang, Jiyuan Ai, Jiakun Wang, Chi sun, Hongcheng Lu, Aoxiao He, Min Li, Yuting Liao, Jun Lei, Fan Zhou, Linquan Wu and Wenjun Liao
    Citation: Journal of Translational Medicine 2022 20:325
    Content type: Research Published on:

  31. Neuroendocrine neoplasms (NENs) represent a heterogeneous class of rare tumors with increasing incidence. They are characterized by the ability to secrete peptide hormones and biogenic amines but other reliabl...

    Authors: Viola Melone, Annamaria Salvati, Domenico Palumbo, Giorgio Giurato, Giovanni Nassa, Francesca Rizzo, Luigi Palo, Alessandro Giordano, Mariarosaria Incoronato, Mario Vitale, Caterina Mian, Immacolata Di Biase, Stefano Cristiano, Viviana Narciso, Monica Cantile, Annabella Di Mauro…
    Citation: Journal of Translational Medicine 2022 20:306
    Content type: Research Published on:

  32. As an important N6-methyladenosine (m6A) regulator, abnormal expression of methyltransferase-like protein 3 (METTL3) has been reported in certain human cancers. Although some data have shown that METTL3 plays an ...

    Authors: Dawei Zhu, Yingting Liu, Junjun Chen, Qi Wang, Yuan Li, Yulan Zhu, Jun Feng and Jingting Jiang
    Citation: Journal of Translational Medicine 2022 20:298
    Content type: Research Published on:

  33. Gastric cancer (GC), as one of the most common malignancies across the globe, is the fourth leading cause of cancer-related deaths. Though a large body of research has been conducted to develop the therapeutic...

    Authors: Guohua Jin, Jianguang Zhang, Tingting Cao, Bang Chen, Yu Tian and Yang Shi
    Citation: Journal of Translational Medicine 2022 20:284
    Content type: Research Published on:

  34. Metabolic disorders are associated with increased incidence, aggressive phenotype and poor outcome of breast cancer (BC) patients. For instance, hyperinsulinemia is an independent risk factor for BC and the in...

    Authors: Domenica Scordamaglia, Francesca Cirillo, Marianna Talia, Maria Francesca Santolla, Damiano Cosimo Rigiracciolo, Lucia Muglia, Azzurra Zicarelli, Salvatore De Rosis, Francesca Giordano, Anna Maria Miglietta, Ernestina Marianna De Francesco, Veronica Vella, Antonino Belfiore, Rosamaria Lappano and Marcello Maggiolini
    Citation: Journal of Translational Medicine 2022 20:263
    Content type: Research Published on:

  35. Lung adenocarcinoma (LUAD) is a heavy social burden worldwide. Because the mechanisms involved in LUAD remain unclear, the prognosis of LUAD remains poor. Consequently, it is urgent to investigate the potentia...

    Authors: Qian Wu, Rui Li, Qing-Xiang Wang, Meng-Yu Zhang, Ting-Ting Liu and Yi-Qing Qu
    Citation: Journal of Translational Medicine 2022 20:260
    Content type: Research Published on:

  36. Emerging evidence has highlighted the critical roles of long noncoding RNAs (lncRNAs) in tumor development and progression. However, the biological functions and underlying mechanisms of DLEU1 in esophageal sq...

    Authors: Qihang Li, Zhiyu Zhang, HongChao Jiang, Jun Hou, Yuhang Chai, Hongxing Nan, Feng Li and Lianghai Wang
    Citation: Journal of Translational Medicine 2022 20:245
    Content type: Research Published on:

  37. RNA adenosine modifications, which are primarily mediated by “writer” enzymes (RMWs), play a key role in epigenetic regulation in various biological processes, including tumorigenesis. However, the expression ...

    Authors: Shijie Chen, Jin Zeng, Liping Huang, Yi Peng, Zuyun Yan, Aiqian Zhang, Xingping Zhao, Jun Li, Ziting Zhou, Sidan Wang, Shengyu Jing, Minghua Hu, Yuezhan Li, Dong Wang, Weiguo Wang, Haiyang Yu…
    Citation: Journal of Translational Medicine 2022 20:228
    Content type: Research Published on:

  38. In recent years, 5-methylcytosine (m5C) RNA modification has emerged as a key player in regulating RNA metabolism and function through coding as well as non-coding RNAs. Accumulating evidence has shown that m5C m...

    Authors: Mingyang Li, Zijia Tao, Yiqiao Zhao, Lei Li, Jianyi Zheng, Zeyu Li and Xiaonan Chen
    Citation: Journal of Translational Medicine 2022 20:214
    Content type: Review Published on:

  39. Hepatocellular carcinoma (HCC) is the most common pathological type of liver cancer. Valosin-containing protein (VCP) is a member of the AAA-ATPase family associated with multiple molecular functions and invo...

    Authors: Zhangya Pu, Dan G. Duda, Yuanyuan Zhu, Siya Pei, Xiaofang Wang, Yan Huang, Panpan Yi, Zebing Huang, Fang Peng, Xingwang Hu and Xuegong Fan
    Citation: Journal of Translational Medicine 2022 20:212
    Content type: Research Published on:

  40. Tanimilast is a novel and selective inhaled inhibitor of phosphodiesterase-4 in advanced clinical development for chronic obstructive pulmonary disease (COPD). Tanimilast is known to exert prominent anti-infla...

    Authors: Hoang Oanh Nguyen, Valentina Salvi, Laura Tiberio, Fabrizio Facchinetti, Mirco Govoni, Gino Villetti, Maurizio Civelli, Ilaria Barbazza, Carolina Gaudenzi, Mauro Passari, Tiziana Schioppa, Francesca Sozio, Annalisa Del Prete, Silvano Sozzani and Daniela Bosisio
    Citation: Journal of Translational Medicine 2022 20:203
    Content type: Research Published on:

  41. Serine/arginine-rich splicing factor 9 (SRSF9) is a classical RNA-binding protein that is essential for regulating gene expression programs through its interaction with target RNA. Whether SRSF9 plays an essen...

    Authors: Xiaoyu Wang, Xiansheng Lu, Ping Wang, Qiaoyu Chen, Le Xiong, Minshan Tang, Chang Hong, Xiaowen Lin, Kaixi Shi, Li Liang and Jie Lin
    Citation: Journal of Translational Medicine 2022 20:198
    Content type: Research Published on:

  42. Hepatocellular carcinoma (HCC), as the most common type of liver cancer, is characterized by high recurrence and metastasis. Circular RNA (circRNA) circ_0036412 was selected for studying the underlying mechani...

    Authors: Liyan Wang, Bin Li, Xiaoyuan Yi, Xuhua Xiao, Qinghua Zheng and Lei Ma
    Citation: Journal of Translational Medicine 2022 20:154
    Content type: Research Published on:

  43. Oral squamous cell carcinoma (OSCC), as one of the commonest malignancies showing poor prognosis, has been increasingly suggested to be modulated by circular RNAs (circRNAs). Through GEO (Gene Expression Omnib...

    Authors: Liang Rong, Bo Chen, Ke Liu, Bingyao Liu, Xinyao He, Juan Liu, Junxia Li, Maodian He, Lei Zhu, Ke Liu, Xiaolei Shi, Yi Shuai and Lei Jin
    Citation: Journal of Translational Medicine 2022 20:148
    Content type: Research Published on:

  44. Adiponectin is an adipocyte-secreted cytokine that enhances insulin sensitivity and attenuates inflammation. Although circulating adiponectin level is often inversely associated with several malignancies, its...

    Authors: Zongmeng Zhang, Jinlin Du, Hui Shi, Shuai Wang, Yunjing Yan, Qihua Xu, Sujin Zhou, Zhenggang Zhao, Yunping Mu, Chaonan Qian, Allan Zijian Zhao, Sumei Cao and Fanghong Li
    Citation: Journal of Translational Medicine 2022 20:89
    Content type: Research Published on:

  46. Colon cancer is a common malignant tumor of the digestive tract, and its incidence is ranked third among gastrointestinal tumors. The present study aims to investigate the role of a novel circular RNA (circCSP...

    Authors: Jin Wang, Lei Zhou, Bingxin Chen, Zhuwen Yu, Jianglei Zhang, Zhe Zhang, Chenrui Hu, Yanjin Bai, Xiaokang Ruan, Shengjia Wang, Jun Ouyang, Airong Wu and Xin Zhao
    Citation: Journal of Translational Medicine 2022 20:58
    Content type: Research Published on:

  47. Gastric cancer (GC) is the fifth leading cause of cancer-related death worldwide and is accompanied by low diagnosis and survival rates. The molecular mechanism of GC must be elucidated to improve treatment st...

    Authors: Zhijun Geng, Jing Li, Sandang Li, Yueyue Wang, Lele Zhang, Qiuzi Hu, Xinru Wang, Lugen Zuo, Xue Song, Xiaofeng Zhang, Sitang Ge and Jianguo Hu
    Citation: Journal of Translational Medicine 2022 20:50
    Content type: Research Published on:

  48. The aberrant expression of E3 ubiquitin ligase Pellino-1 (PELI1) contributes to several human cancer development and progression. However, its expression patterns and functional importance in papillary thyroid...

    Authors: Tingting Zheng, Youxing Zhou, Xiaowei Xu, Xin Qi, Jiameng Liu, Yanan Pu, Shan Zhang, Xuerong Gao, Xinkai Luo, Mei Li, Xuefeng Wang, Liyang Dong, Ying Wang and Chaoming Mao
    Citation: Journal of Translational Medicine 2022 20:20
    Content type: Research Published on:

Journal of Translational Medicine

ISSN: 1479-5876

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