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Nutrition & Metabolism

Section edited by Laura Soldati

This section aims to provide a platform for the interaction and mutual validation between basic and applied research in the field of nutrition. In the area of Translational Medicine, we believe that the field ought to be taken into greater account in order to generate advanced applications for diagnosis and therapy and, at the same time, to develop new instruments of investigation.

Studies on all aspects of nutrition and metabolism with applications in medicine and biotechnology will be considered for publication. The section not only welcomes contributions that employ traditional clinical, metabolic and epidemiologic methods, but is also interested in molecular and cell biology applied to human and animal nutrition.

Featured articles

Hericium erinaceus mycelium and its isolated erinacine A protection from MPTP-induced neurotoxicity through the ER stress, triggering an apoptosis cascade
Hsing-Chun Kuo, et al

Obesity and colorectal cancer: molecular features of adipose tissue
Javier Martinez-Useros and Jesus Garcia-Foncillas



Role of a polyphenol-enriched preparation on chemoprevention of mammary carcinoma through cancer stem cells and inflammatory pathways modulation
Tri Vuong, et al

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  1. Early-stage detection of chronic kidney diseases (CKD) is important to treatment that may slow and occasionally halt CKD progression. CKD of diverse etiologies share similar histologic patterns of glomeruloscl...

    Authors: Colleen S. Curran and Jeffrey B. Kopp
    Citation: Journal of Translational Medicine 2023 21:706
    Content type: Review Published on:

  2. The increasing prevalence of metabolic and cardiovascular diseases poses a significant challenge to global healthcare systems. Regular physical activity (PA) is recognized for its positive impact on cardiovasc...

    Authors: Chang Sheng, Weihua Huang, Wei Wang, Guoqiang Lin, Mingmei Liao and Pu Yang
    Citation: Journal of Translational Medicine 2023 21:705
    Content type: Research Published on:

  3. Non-alcoholic fatty liver disease (NAFLD) is a common liver disease increasing cardiovascular disease (CVD) morbidity and mortality. Autoantibodies against apolipoprotein A-1 (AAA-1) are a possible novel CVD r...

    Authors: Sabrina Pagano, Stephan J. L. Bakker, Catherine Juillard, Stefania Vossio, Dimitri Moreau, Karim J. Brandt, François Mach, Robin P. F. Dullaart and Nicolas Vuilleumier
    Citation: Journal of Translational Medicine 2023 21:694
    Content type: Research Published on:

  4. Migraine is the second world’s cause of disability. Among non-pharmacological treatments, nutritional intervention, particularly ketogenic diet, represents one of the most promising approaches.

    Authors: Massimiliano Caprio, Eleonora Moriconi, Elisabetta Camajani, Alessandra Feraco, Vincenzo Marzolla, Laura Vitiello, Stefania Proietti, Andrea Armani, Stefania Gorini, Caterina Mammi, Gabriella Egeo, Cinzia Aurilia, Giulia Fiorentini, Carlo Tomino and Piero Barbanti
    Citation: Journal of Translational Medicine 2023 21:692
    Content type: Research Published on:

  5. Metabolic syndrome (MetS), a worldwide public health problem, affects human health and quality of life in a dramatic manner. A growing evidence base suggests that MetS is strongly associated with levels of sys...

    Authors: Yang Zhao, Wenyu Shao, Qihan Zhu, Rui Zhang, Tao Sun, Bijia Wang and Xiaofei Hu
    Citation: Journal of Translational Medicine 2023 21:691
    Content type: Research Published on:

  6. There is little prospective evidence exists about whether adherence to a diabetes risk reduction diet (DRRD) is related to a significant reduction in renal cancer risk. We sought to clarify whether adherence t...

    Authors: Ling Xiang, Yi Xiao, Zhiquan Xu, Haoyun Luo, Xiaorui Ren, Qi Wei, Zhiyong Zhu, Yahui Jiang, Yunhao Tang, Hongmei He, Zhihang Zhou, Haitao Gu, Yaxu Wang and Linglong Peng
    Citation: Journal of Translational Medicine 2023 21:684
    Content type: Research Published on:

  7. Previous studies have assessed the association between antidiabetic drugs and stroke risk, but the results are inconsistent. Mendelian randomization (MR) was used to assess effects of antidiabetic drugs on str...

    Authors: Yahui Zhu, Mao Li, Hongfen Wang, Fei Yang, Xinyuan Pang, Rongrong Du, Jinghong Zhang and Xusheng Huang
    Citation: Journal of Translational Medicine 2023 21:681
    Content type: Research Published on:

  8. This study aims to comprehensively investigate the phenotypic and genetic relationships between four common lipids (high-density lipoprotein cholesterol, HDL-C; low-density lipoprotein cholesterol, LDL-C; tota...

    Authors: Yutong Wang, Li Zhang, Wenqiang Zhang, Mingshuang Tang, Huijie Cui, Xueyao Wu, Xunying Zhao, Lin Chen, Peijing Yan, Chao Yang, Chenghan Xiao, Yanqiu Zou, Yunjie Liu, Ling Zhang, Chunxia Yang, Yuqin Yao…
    Citation: Journal of Translational Medicine 2023 21:671
    Content type: Research Published on:

  9. Plant-based dietary patterns may affect colorectal cancer (CRC) related outcomes, while risks differ in the quality of plant foods. We aimed to examine the association of plant-based diet quality with risks of...

    Authors: Fubin Liu, Yanling Lv, Yu Peng, Yating Qiao, Peng Wang, Changyu Si, Xixuan Wang, Jianxiao Gong, Huijun Zhou, Ming Zhang, Liangkai Chen and Fangfang Song
    Citation: Journal of Translational Medicine 2023 21:669
    Content type: Research Published on:

  10. Osteoporosis is a systemic bone disease characterized by low bone mass, microarchitectural deterioration, increased bone fragility, and fracture susceptibility. It commonly occurs in older people, especially p...

    Authors: Dong Wu, Lei Li, Zhun Wen and Guangbin Wang
    Citation: Journal of Translational Medicine 2023 21:668
    Content type: Review Published on:

  11. The prevention and treatment of osteoarthritis (OA) pose a major challenge in its research. The synovium is a critical tissue in the systematic treatment of OA. The present study aimed to investigate potential...

    Authors: Zhuangzhuang Jin, He Zhang, Lunhao Bai, Lingyu Yue, Weiming Zhang, Jiajian Liang, Bohan Chang, Yue Yang, Zhehan Hu, Liang Chen and Chuanji Guo
    Citation: Journal of Translational Medicine 2023 21:661
    Content type: Research Published on:

  12. Vitamin D deficiency is common among the population, but its relationship with mortality of postmenopausal females is unclear. The aim of this study is to explore the association between serum 25-Hydroxyvitami...

    Authors: Jia-Wei Shi, Jiang-Nan Wu, Xiao-Yong Zhu, Wen-Hui Zhou, Jin-Ying Yang and Ming-Qing Li
    Citation: Journal of Translational Medicine 2023 21:629
    Content type: Research Published on:

  13. Owing to the heterogeneity of Alzheimer's disease (AD), its pathogenic mechanisms are yet to be fully elucidated. Evidence suggests an important role of metabolism in the pathophysiology of AD. Herein, we iden...

    Authors: Piaopiao Lian, Xing Cai, Cailin Wang, Ke Liu, Xiaoman Yang, Yi Wu, Zhaoyuan Zhang, Zhuoran Ma, Xuebing Cao and Yan Xu
    Citation: Journal of Translational Medicine 2023 21:628
    Content type: Research Published on:

  14. Triglyceride glucose index (TyG index) has been recommended as an alternative indicator of insulin resistance. However, the association between TyG and regression from prediabetes to normoglycemia remains to b...

    Authors: Xiaojie Chen, Danfeng Liu, Weiting He, Haofei Hu and Wenjian Wang
    Citation: Journal of Translational Medicine 2023 21:624
    Content type: Research Published on:

  15. Chronic obstructive pulmonary disease (COPD) patients often exhibit gastrointestinal symptoms, A potential association between COPD and Colorectal Cancer (CRC) has been indicated, warranting further examination.

    Authors: Youtao Zhou, Zikai Lin, Shuojia Xie, Yuan Gao, Haobin Zhou, Fengzhen Chen, Yuewu Fu, Cuiyan Yang and Chuanfeng Ke
    Citation: Journal of Translational Medicine 2023 21:587
    Content type: Research Published on:

  16. Insulin resistance (IR) is considered the main driver of obesity related metabolic complications, and is related to oxidative stress and inflammation, which in turn promote each other. There is currently no sp...

    Authors: Álvaro González-Domínguez, Thalía Belmonte, Jesús Domínguez-Riscart, Pablo Ruiz-Ocaña, Inés Muela-Zarzuela, Ana Saez-Benito, Raúl Montañez-Martínez, Rosa M. Mateos and Alfonso M. Lechuga-Sancho
    Citation: Journal of Translational Medicine 2023 21:559
    Content type: Research Published on:

  17. Limited research has been conducted on the potential relationship between the dietary inflammation index (DII) and mortality, particularly in individuals with Helicobacter pylori (H. pylori) infection. This st...

    Authors: Yu-Jun Xiong, Lei-Lei Du, Yun-Lian Diao, Jun Wen, Xiang-Bin Meng, Jun Gao, Chun-Li Shao, Wen-Yao Wang, Xing-yun Zhu and Yi-Da Tang
    Citation: Journal of Translational Medicine 2023 21:538
    Content type: Research Published on:

  18. Studies have examined the effect of weight change on osteoporosis, but the results were controversial. Among them, few had looked at weight change over the life span. This study aimed to fill this gap and inve...

    Authors: Jiacheng Wang, Yi Zheng, Yawen Wang, Chengjun Zhang, Yanfeng Jiang, Chen Suo, Mei Cui, Tiejun Zhang, Xingdong Chen and Kelin Xu
    Citation: Journal of Translational Medicine 2023 21:536
    Content type: Research Published on:

  19. No evidence has been found of a relationship between remnant cholesterol (RC) and the likelihood of gestational diabetes mellitus (GDM) in pregnant women. The aim of our study was to investigate the link betwe...

    Authors: Yajing Gao, Yanhua Hu and Lan Xiang
    Citation: Journal of Translational Medicine 2023 21:531
    Content type: Research Published on:

  20. This paper aimed to examine the effects of probiotics on eight factors in overweight or obese children by meta-analysis, namely, body mass index (BMI), total cholesterol (TC), triglyceride (TG), high-density l...

    Authors: Ya Li, Tonghua Liu, Lingling Qin and Lili Wu
    Citation: Journal of Translational Medicine 2023 21:525
    Content type: Review Published on:

  21. Abdominal obesity has long been considered as a crucial risk factor of stroke. Chinese visceral adiposity index (CVAI), a novel surrogate indicator of abdominal obesity, has been confirmed as a better predicto...

    Authors: Zenglei Zhang, Lin Zhao, Yiting Lu, Xu Meng and Xianliang Zhou
    Citation: Journal of Translational Medicine 2023 21:518
    Content type: Research Published on:

  23. Diet may influence biological aging and the discrepancy (∆age) between a subject’s biological age (BA) and chronological age (CA). We aimed to investigate the correlation of dietary flavonoids with the ∆age of...

    Authors: Wenmin Xing, Wenyan Gao, Zhenlei Zhao, Xiaogang Xu, Hongyan Bu, Huili Su, Genxiang Mao and Jun Chen
    Citation: Journal of Translational Medicine 2023 21:492
    Content type: Research Published on:

  24. The pathogenic mechanisms shared between kidney stones and diabetes at the transcriptional level remain elusive, and the molecular mechanisms by which resveratrol exerts its protective effects against these co...

    Authors: Shanlin Shen, Jiafeng Wei, Weiting Kang and Tengteng Wang
    Citation: Journal of Translational Medicine 2023 21:491
    Content type: Research Published on:

  25. Diabetic nephropathy (DN) is one of the serious microvascular complications of diabetes mellitus (DM). A growing body of research has demonstrated that the inflammatory state plays a critical role in the incid...

    Authors: Meng Yan, Wenwen Li, Rui Wei, Shuwen Li, Yan Liu, Yuqian Huang, Yunye Zhang, Zihao Lu and Qian Lu
    Citation: Journal of Translational Medicine 2023 21:490
    Content type: Research Published on:

  26. The plant-based paleolithic diet (PD) and the paleolithic-like lifestyle (PLL) may reduce the risk of chronic diseases, including colorectal adenomas. These dietary and lifestyle approaches are proposed to exe...

    Authors: Yi Xiao, Yaxu Wang, Haitao Gu, Zhiquan Xu, Yunhao Tang, Hongmei He, Linglong Peng and Ling Xiang
    Citation: Journal of Translational Medicine 2023 21:482
    Content type: Research Published on:

  27. Obesity is a condition that is often associated with sleep disorders, including reduced sleep quality (SQ). Very low calorie ketogenic diet (VLCKD) has proven to be effective in the management of obesity and a...

    Authors: Luigi Barrea, Ludovica Verde, Cherubino Di Lorenzo, Silvia Savastano, Annamaria Colao and Giovanna Muscogiuri
    Citation: Journal of Translational Medicine 2023 21:479
    Content type: Research Published on:

  28. Diabetic retinopathy (DR) development is associated with disturbances in the gut microbiota and related metabolites. Butyric acid is one of the short-chain fatty acids (SCFAs), which has been found to possess ...

    Authors: Yinhua Huang, Zhijie Wang, Bo Ye, Jacey Hongjie MA, Shangli Ji, Wang Sheng, Suna Ye, Yiwen Ou, Yanfang Peng, Xu Yang, Jiansu Chen and Shibo Tang
    Citation: Journal of Translational Medicine 2023 21:451
    Content type: Research Published on:

  29. This systematic review and meta-analysis study aimed to evaluate the effectiveness of probiotics supplementation on glycaemic control in patients with type 2 diabetes mellitus (T2DM) based on the data from the...

    Authors: Guang Li, Hao Feng, Xin-Liang Mao, Yan-Jun Deng, Xiao-Bao Wang, Qiong Zhang, Yan Guo and Su-Mei Xiao
    Citation: Journal of Translational Medicine 2023 21:442
    Content type: Review Published on:

  30. Impaired sensitivity to thyroid hormones is a newly proposed clinical entity associated with hyperuricemia in the subclinical hypothyroid population. However, it is unknown whether the association exists in th...

    Authors: Zhiyuan Wu, Yue Jiang, Pingan Li, Yutao Wang, Haiping Zhang, Zhiwei Li, Xia Li, Lixin Tao, Bo Gao and Xiuhua Guo
    Citation: Journal of Translational Medicine 2023 21:436
    Content type: Research Published on:

  31. Sarcopenia has been recognized as a third category of complications in people with diabetes. However, few studies focus on the reduction of skeletal muscle mass in young people with diabetes. The aim of this s...

    Authors: Ruina Li, Sixian Lin, Jiayuan Tu, Yongzhuang Chen, Bin Cheng, Xiaoqiao Mo and Tian Xie
    Citation: Journal of Translational Medicine 2023 21:393
    Content type: Research Published on:

  33. Diabetic kidney disease (DKD) is a severe complication of diabetes. Currently, no effective measures are available to reduce the risk of DKD progression. This study aimed to establish a weighted risk model to ...

    Authors: Tianxiao Zhang, Xiaodan Wang, Yueying Zhang, Ying Yang, Congying Yang, Huiyi Wei and Qingbin Zhao
    Citation: Journal of Translational Medicine 2023 21:381
    Content type: Research Published on:

  34. Diabetic kidney disease (DKD) has been the leading cause of chronic kidney disease in developed countries. Evidence of the benefits of resveratrol (RES) for the treatment of DKD is accumulating. However, compr...

    Authors: Shengnan Chen, Bo Li, Lei Chen and Hongli Jiang
    Citation: Journal of Translational Medicine 2023 21:380
    Content type: Research Published on:

  35. Observational studies and conventional Mendelian randomization (MR) studies showed inconclusive evidence to support the association between omega-3 fatty acids and type 2 diabetes. We aim to evaluate the causa...

    Authors: Chunyan Hu, Yulin Zhou, Xueyan Wu, Xiaojing Jia, Yuanyue Zhu, Ruizhi Zheng, Shuangyuan Wang, Lin Lin, Hongyan Qi, Hong Lin, Mian Li, Tiange Wang, Zhiyun Zhao, Min Xu, Yu Xu, Yuhong Chen…
    Citation: Journal of Translational Medicine 2023 21:370
    Content type: Research Published on:

  36. Higher vitamin D concentrations and grip strength contribute to lower individual-level risk of dementia, while apolipoprotein 4 (APOE e4) genotype carries increases dementia risk, but whether combination of id...

    Authors: Jiangtao Feng, Qi Wang and Yuan Zhang
    Citation: Journal of Translational Medicine 2023 21:355
    Content type: Research Published on:

  37. Central precocious puberty (CPP) is a common disease in prepubertal children and results mainly from disorders in the endocrine system. Emerging evidence has highlighted the involvement of gut microbes in horm...

    Authors: Xiaoyan Huang, Jixiong Chen, Haozhe Zou, Peng Huang, Hailing Luo, Haidan Li, Yuhua Cai, Li Liu, Yongsheng Li, Xiaojie He and Wei Xiang
    Citation: Journal of Translational Medicine 2023 21:316
    Content type: Research Published on:

  38. Alcoholism is a widespread and damaging behaviour of people throughout the world. Long-term alcohol consumption has resulted in alcoholic liver disease (ALD) being the leading cause of chronic liver disease. M...

    Authors: Chuyun Yan, Wanting Hu, Jinqi Tu, Jinyao Li, Qionglin Liang and Shuxin Han
    Citation: Journal of Translational Medicine 2023 21:300
    Content type: Review Published on:

  39. Micronutrients have been associated with disease severity and poorer clinical outcomes in patients with COVID-19. However, there is a paucity of studies examining if the relationship with micronutrient status ...

    Authors: Josh McGovern, John Wadsworth, Anthony Catchpole, Conor Richards, Donald C. McMillan, Tadhg Kelliher, Emma Goodall, Ellie Murray, Terry Melaugh, Shannon McPhillips, Kathryn Brice, Katie Barbour, Sophie Robinson, Peter Moffitt, Olivia Kemp, Dinesh Talwar…
    Citation: Journal of Translational Medicine 2023 21:284
    Content type: Research Published on:

  40. There are inconsistent results of cohort studies analyzing the association between fish intake and mortality.

    Authors: Jian Zhou, Xiankui Tan, Yihan Li, Rongjun Wan, Ziyi Wu, Zhengjun Lin, Wanchun Wang, Yingquan Luo and Tang Liu
    Citation: Journal of Translational Medicine 2023 21:280
    Content type: Research Published on:

  41. Non-alcoholic fatty liver disease (NAFLD) is a serious public health issue globally, currently, the treatment of NAFLD lies still in the labyrinth. In the inchoate stage, the combinatorial application of food ...

    Authors: Ki-Kwang Oh, Sang-Jun Yoon, Su-Been Lee, Sang Youn Lee, Haripriya Gupta, Raja Ganesan, Satya Priya Sharma, Sung-Min Won, Jin-Ju Jeong, Dong Joon Kim and Ki-Tae Suk
    Citation: Journal of Translational Medicine 2023 21:263
    Content type: Research Published on:

  42. Type 2 diabetes mellitus (T2DM), one of the main types of Noncommunicable diseases (NCDs), is a systemic inflammatory disease characterized by dysfunctional pancreatic β-cells and/or peripheral insulin resista...

    Authors: Duygu Ağagündüz, Mehmet Arif Icer, Ozge Yesildemir, Tevfik Koçak, Emine Kocyigit and Raffaele Capasso
    Citation: Journal of Translational Medicine 2023 21:240
    Content type: Review Published on:

  43. The impact of integrated lifestyles on health has attracted a lot of attention. It remains unclear whether adherence to low-risk healthy lifestyle factors is protective in individuals with metabolic syndrome a...

    Authors: Mengying Niu, Jiahao Chen, Rongyao Hou, Yu Sun, Qi Xiao, Xudong Pan and Xiaoyan Zhu
    Citation: Journal of Translational Medicine 2023 21:239
    Content type: Research Published on:

  44. To examine the hypothesis that obesity complicated by the metabolic syndrome, compared to uncomplicated obesity, has distinct molecular signatures and metabolic pathways.

    Authors: Fayaz Ahmad Mir, Raghvendra Mall, Ehsan Ullah, Ahmad Iskandarani, Farhan Cyprian, Tareq A. Samra, Meis Alkasem, Ibrahem Abdalhakam, Faisal Farooq, Shahrad Taheri and Abdul-Badi Abou-Samra
    Citation: Journal of Translational Medicine 2023 21:229
    Content type: Research Published on:

  45. Diabetic nephropathy (DN) is a main cause of chronic renal failure. Despite decades of extensive study, the molecular mechanisms underlying diabetic tubulointerstitial injury remain unclear. We aim to identify...

    Authors: Jialu Liu, Guangzhong Duan, Wenxia Yang, Shumin Zhang, Fuyou Liu, Youming Peng, Lin Sun, Yu Liu and Li Xiao
    Citation: Journal of Translational Medicine 2023 21:228
    Content type: Research Published on:

  46. The impact of metabolically healthy obesity (MHO) on kidney dysfunction remains debatable. Moreover, few studies have focused on the early stages of kidney dysfunction indicated by hyperfiltration and mildly r...

    Authors: Hong Zhang, Rui Chen, Xiaohong Xu, Minxing Yang, Wenrong Xu, Shoukui Xiang, Long Wang, Xiaohong Jiang, Fei Hua and Xiaolin Huang
    Citation: Journal of Translational Medicine 2023 21:216
    Content type: Research Published on:

  47. Increased circulating uric acid (UA) concentration may disrupt cardiac function in heart failure patients, but the specific mechanism remains unclear. Here, we postulate that hyperuremia induces sterol regulat...

    Authors: Bowen Lou, Haoyu Wu, Hannes Ott, Katrin Bennewitz, Chen Wang, Gernot Poschet, Hui Liu, Zuyi Yuan, Jens Kroll and Jianqing She
    Citation: Journal of Translational Medicine 2023 21:199
    Content type: Research Published on:

  48. Body mass index (BMI) and lipid parameters are the most commonly used anthropometric parameters and biomarkers for assessing nonalcoholic fatty liver disease (NAFLD) risk. This study aimed to assess and quanti...

    Authors: Song Lu, Qiyang Xie, Maobin Kuang, Chong Hu, Xinghui Li, Huijian Yang, Guotai Sheng, Guobo Xie and Yang Zou
    Citation: Journal of Translational Medicine 2023 21:192
    Content type: Research Published on:

  49. Despite the many signs of progress in pharmacotherapies, metabolic syndrome (MetS) is one of the main public-health burdens worldwide. Our study aimed to compare the effect of breastfeeding (BF) in women with ...

    Authors: Maryam Farahmand, Maryam Rahmati, Fereidoun Azizi and Fahimeh Ramezani Tehrani
    Citation: Journal of Translational Medicine 2023 21:177
    Content type: Research Published on:

  50. Previous studies have reported that high fasting plasma glucose (FPG), even that within the normal range, is associated with the risk of type 2 diabetes (T2D). Nevertheless, these findings are limited to speci...

    Authors: Linfeng He, Wenbin Zheng, Zeyu Li, Lu Chen, Wen Kong and Tianshu Zeng
    Citation: Journal of Translational Medicine 2023 21:175
    Content type: Research Published on:
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