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Immunobiology and Immunotherapy

Section edited by Alessandra Cesano

The Immunobiology and Immunotherapy section aims to enrich the communication between basic biological and immunological sciences and the clinical investigation arena.

As immunology has evolved to be a central discipline connected to a wide range of therapeutic areas, the number and diversity of platform technologies has also increased, spanning small molecules, biologics, microbial vectors and cells. Such levels of activity require appropriate means to share new knowledge and to catalyze the development of the field. This section aims to provide such a platform and welcomes submissions across all disciplines, including inflammation, autoimmunity, transplantation, metabolic disorders.

The section was founded with the Society for Immunotherapy of Cancer (SITC) under the title "Tumor immunology and biological cancer therapy" and Pedro Romero was the founding Section Editor.

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  1. Infections which complicate rheumatic diseases such as Rheumatoid Arthritis (RA) and Spondyloarthropathy (SpA) (Psoriatic Arthritis [PA] and Ankylosing Spondylitis [AS]), may cause significant morbidity and mo...

    Authors: Valentina Germano, Maria Sofia Cattaruzza, John Osborn, Aurora Tarantino, Roberta Di Rosa, Simonetta Salemi and Raffaele D’Amelio
    Citation: Journal of Translational Medicine 2014 12:77
    Content type: Research Published on:

  2. Interleukin-37 (IL-37), a new member of IL-1 family cytokine, is recently identified as a natural inhibitor of innate immunity. This study aimed to measure the peripheral blood mononuclear cells (PBMCs) and se...

    Authors: Liang Ye, Ling Ji, Zhongyang Wen, Yanfei Zhou, Dongsheng Hu, Yanqun Li, Ting Yu, Bingni Chen, Jinshun Zhang, Liping Ding, Jing Du and Zhong Huang
    Citation: Journal of Translational Medicine 2014 12:69
    Content type: Research Published on:

  3. To evaluate the safety of combination vaccine treatment of multiple peptides, phase I clinical trial was conducted for patients with advanced colorectal cancer using five novel HLA-A*2402-restricted peptides, ...

    Authors: Shoichi Hazama, Yusuke Nakamura, Hiroko Takenouchi, Nobuaki Suzuki, Ryouichi Tsunedomi, Yuka Inoue, Yoshihiro Tokuhisa, Norio Iizuka, Shigefumi Yoshino, Kazuyoshi Takeda, Hirokazu Shinozaki, Akira Kamiya, Hiroyuki Furukawa and Masaaki Oka
    Citation: Journal of Translational Medicine 2014 12:63
    Content type: Research Published on:

  4. The prognosis of patients with advanced biliary tract cancer (BTC) is extremely poor and only a few standard treatments are available for this condition. We performed a phase I trial to investigate the safety,...

    Authors: Atsushi Aruga, Nobuhiro Takeshita, Yoshihito Kotera, Ryuji Okuyama, Norimasa Matsushita, Takehiro Ohta, Kazuyoshi Takeda and Masakazu Yamamoto
    Citation: Journal of Translational Medicine 2014 12:61
    Content type: Research Published on:

  5. Mutant Ras oncogenes produce proteins that are unique to cancer cells and represent attractive targets for vaccine therapy. We have shown previously that vaccinating cancer patients with mutant ras peptides is fe...

    Authors: Osama E Rahma, J Michael Hamilton, Malgorzata Wojtowicz, Omar Dakheel, Sarah Bernstein, David J Liewehr, Seth M Steinberg and Samir N Khleif
    Citation: Journal of Translational Medicine 2014 12:55
    Content type: Research Published on:

  6. Tumor Associated Antigens are characterized by spontaneous immune response in cancer patients as a consequence of overexpression and epitope-presentation on MHC class I/II machinery. Matrix Metalloprotease 11 ...

    Authors: Giuseppe Roscilli, Manuela Cappelletti, Claudia De Vitis, Gennaro Ciliberto, Arianna Di Napoli, Luigi Ruco, Rita Mancini and Luigi Aurisicchio
    Citation: Journal of Translational Medicine 2014 12:54
    Content type: Research Published on:

  7. Regulatory T cells (Treg) protect kidney against ischemia reperfusion (IR) injury via suppressing innate immunity, but the mechanism has not been fully clarified. Soluble fibrinogen-like protein 2 (sFGL2), a n...

    Authors: Zitong Zhao, Cheng Yang, Long Li, Tian Zhao, Lingyan Wang, Ruiming Rong, Bin Yang, Ming Xu and Tongyu Zhu
    Citation: Journal of Translational Medicine 2014 12:53
    Content type: Research Published on:

  8. Epidemiological evidence confirmed that raw cow’s milk consumption in the first year of life protects against the development of atopic diseases and increases the number of regulatory T-cells (Tregs). However,...

    Authors: Bodo C Melnik, Swen Malte John and Gerd Schmitz
    Citation: Journal of Translational Medicine 2014 12:43
    Content type: Review Published on:

  9. The coinhibitory receptor Programmed Death-1 (PD-1) inhibits effector functions of activated T cells and prevents autoimmunity, however, cancer hijack this pathway to escape from immune attack. The costimulato...

    Authors: Lei Lu, Xiaobing Xu, Bin Zhang, Rongsheng Zhang, Hongzan Ji and Xuan Wang
    Citation: Journal of Translational Medicine 2014 12:36
    Content type: Research Published on:

  10. T regulatory cell (Treg) plays a critical role in respiratory allergy and allergen-specific immunotherapy (SIT), and γδ T cells might participate in mediating Treg quantity and/or function in some immunologica...

    Authors: Rui Zheng, Xiuli Wu, Xuekun Huang, Yulian Chen, Qintai Yang, Yangqiu Li and Gehua Zhang
    Citation: Journal of Translational Medicine 2014 12:24
    Content type: Research Published on:

  11. Mixed cryoglobulinemia (MC) is a HCV-related lymphoproliferative disorder generally associated with advanced liver disease. Liver stiffness has been significantly correlated with histopathological stage of fib...

    Authors: Cristina Stasi, Elisa Triboli, Umberto Arena, Teresa Urraro, Antonio Petrarca, Laura Gragnani, Giacomo Laffi and Anna Linda Zignego
    Citation: Journal of Translational Medicine 2014 12:21
    Content type: Research Published on:

  12. Monoclonal antibodies (mAb), such as trastuzumab are a valuable addition to breast cancer therapy. Data obtained from neoadjuvant settings revealed that antibody-dependent cell-mediated cytotoxicity (ADCC) is ...

    Authors: Branka Petricevic, Johannes Laengle, Josef Singer, Monika Sachet, Judit Fazekas, Guenther Steger, Rupert Bartsch, Erika Jensen-Jarolim and Michael Bergmann
    Citation: Journal of Translational Medicine 2013 11:307
    Content type: Research Published on:

  13. Heat shock proteins (HSPs) are capable of promoting antigen presentation of chaperoned peptides through interactions with receptors on antigen presenting cells. This property of HSPs suggests a potential funct...

    Authors: Juhong Jiang, Dan Xie, Wenmin Zhang, Gang Xiao and Jianming Wen
    Citation: Journal of Translational Medicine 2013 11:300
    Content type: Research Published on:

  14. For thousands of years, it remains unclear why Chinese prefer complex herbal remedy and seldom try to purify it. One of the reasons is that they believe Chinese herbs compared to Western drugs are relatively l...

    Authors: Ling-Jun Ho, Wen-Liang Chang, Ann Chen, Ping Chao and Jenn-Haung Lai
    Citation: Journal of Translational Medicine 2013 11:294
    Content type: Research Published on:

  15. We previously developed an immunotherapy treatment utilizing a cancer vaccine reagent KIF20A-66 in order to treat pancreatic cancer. KIF20A-66 is HLA-A24-restricted epitope peptide derived from KIF20A, a membe...

    Authors: Shingo Asahara, Kazuyoshi Takeda, Kenji Yamao, Hiroyuki Maguchi and Hiroki Yamaue
    Citation: Journal of Translational Medicine 2013 11:291
    Content type: Research Published on:

  16. The capacity of patient’s Natural Killer cells (NKs) to be activated for cytolysis is an important prerequisite for the success of antibody-derived agents such as single-chain triplebodies (triplebodies) in ca...

    Authors: Todd A Braciak, Sarah Wildenhain, Claudia C Roskopf, Ingo A Schubert, Georg H Fey, Uwe Jacob, Karl-Peter Hopfner and Fuat S Oduncu
    Citation: Journal of Translational Medicine 2013 11:289
    Content type: Research Published on:

  17. Both apoptosis and autoantibodies are important factors associated with disease activity in the pathogenesis of systemic lupus erythematosus (SLE). This study tested the hypothesis that increased leukocyte apo...

    Authors: Yu-Jih Su, Tien-Tsai Cheng, Chung-Jen Chen, Wen-Chan Chiu, Chung-Yuan Hsu, Wen-Neng Chang, Nai-Wen Tsai, Chia-Te Kung, Hung-Chen Wang, Wei-Che Lin, Chih-Cheng Huang, Ya-Ting Chang, Chih-Min Su, Yi-Fang Chiang, Ben-Chung Cheng, Yu-Jun Lin…
    Citation: Journal of Translational Medicine 2013 11:261
    Content type: Research Published on:

  18. HLA abnormalities on tumour cells for immune escape have been widely described. In addition, cellular components of the tumour microenvironment, in particular myeloid derived suppressor cells (MDSC) and altern...

    Authors: Maddalena Marchesi, Emilia Andersson, Lisa Villabona, Barbara Seliger, Andreas Lundqvist, Rolf Kiessling and Giuseppe V Masucci
    Citation: Journal of Translational Medicine 2013 11:247
    Content type: Review Published on:

  19. Cholesteryl pullulan (CHP) is a novel antigen delivery system for cancer vaccines. This study evaluated the safety, immune responses and clinical outcomes of patients who received the CHP-NY-ESO-1 complex vacc...

    Authors: Shinichi Kageyama, Hisashi Wada, Kei Muro, Yasumasa Niwa, Shugo Ueda, Hiroshi Miyata, Shuji Takiguchi, Sahoko H Sugino, Yoshihiro Miyahara, Hiroaki Ikeda, Naoko Imai, Eiichi Sato, Tomomi Yamada, Masaharu Osako, Mami Ohnishi, Naozumi Harada…
    Citation: Journal of Translational Medicine 2013 11:246
    Content type: Research Published on:

  20. As organ shortage is increasing, the acceptance of marginal donors increases, which might result in poor organ function and patient survival. Mostly, organ damage is caused during brain death (BD), cold ischem...

    Authors: Philipp Stiegler, Michael Sereinigg, Andreas Puntschart, Andrea Bradatsch, Thomas Seifert-Held, Iris Wiederstein-Grasser, Bettina Leber, Elke Stadelmeyer, Nadia Dandachi, Siglinde Zelzer, Florian Iberer and Vanessa Stadlbauer
    Citation: Journal of Translational Medicine 2013 11:244
    Content type: Research Published on:

  21. Dendritic cells (DCs) are important mediators of anti-tumor immune responses. We hypothesized that an in-depth analysis of dendritic cells and their spatial relationships to each other as well as to other immu...

    Authors: Andrew Y Chang, Nupur Bhattacharya, Jian Mu, A Francesca Setiadi, Valeria Carcamo-Cavazos, Gerald H Lee, Diana L Simons, Sina Yadegarynia, Kaveh Hemati, Adam Kapelner, Zheng Ming, David N Krag, Erich J Schwartz, Danny Z Chen and Peter P Lee
    Citation: Journal of Translational Medicine 2013 11:242
    Content type: Research Published on:

  22. In this study, we developed a pharmacokinetic (PK)- pharmacodynamic (PD) model of a new sustained release formulation of interferon-α-2a (SR-IFN-α) using the blood concentration of IFN-α and neopterin in order...

    Authors: Sangil Jeon, Jae-Hyeon Juhn, Seunghoon Han, Jongtae Lee, Taegon Hong, Jeongki Paek and Dong-Seok Yim
    Citation: Journal of Translational Medicine 2013 11:240
    Content type: Research Published on:

  23. Alveolar soft part sarcoma (ASPS) is a rare soft tissue sarcoma and the clinical management of patients with unresectable, metastatic disease is still challenging. ASPS expresses an array of potentially therap...

    Authors: Chiara Castelli, Marcella Tazzari, Tiziana Negri, Barbara Vergani, Licia Rivoltini, Silvia Stacchiotti and Silvana Pilotti
    Citation: Journal of Translational Medicine 2013 11:237
    Content type: Commentary Published on:

  24. Azathiopurine (AZA) is efficacious for maintenance remission of Crohn’s disease (CD) at the standard dose of 2.0-2.5 mg/kg for Caucasian. It has been reported that the lower dose (1.0-2.0 mg/kg) in some Asian ...

    Authors: Jianghong Wu, Yan Gao, Chuanhua Yang, Xueqing Yang, Xuhang Li and Shudong Xiao
    Citation: Journal of Translational Medicine 2013 11:235
    Content type: Research Published on:

  25. Resistin increases during several inflammatory diseases and after intracerebral bleeding or head trauma. Resistin activates the endothelium and may initiate an inflammatory response. No data are available on r...

    Authors: Simona Oltean, Rille Pullerits, Anne Flodén, Michael Olausson and Mihai Oltean
    Citation: Journal of Translational Medicine 2013 11:233
    Content type: Research Published on:

  26. Primary cutaneous lymphomas (CLs), characterized by an accumulation of clonal T or B lymphocytes preferentially localized in the skin, have been successfully treated with interferons (IFNs) which counterbalanc...

    Authors: Nathalie Accart, Mirjana Urosevic-Maiwald, Reinhard Dummer, Vincent Bataille, Nadine Kehrer, Cristina Niculescu, Jean-Marc Limacher, Marie-Pierre Chenard, Jean-Yves Bonnefoy and Ronald Rooke
    Citation: Journal of Translational Medicine 2013 11:226
    Content type: Research Published on:

  27. Antibodies binding to citrullinated proteins are a frequent finding in rheumatoid arthritis patients and may precede the onset of clinical symptoms several years. The antibodies are a predisposing factor for b...

    Authors: Sanna Turunen, Marja-Kaisa Koivula, Jukka Melkko, Eeva Alasaarela, Petri Lehenkari and Juha Risteli
    Citation: Journal of Translational Medicine 2013 11:224
    Content type: Research Published on:

  28. Targeted therapies directed at commonly overexpressed pathways in melanoma have clinical activity in numerous trials. Little is known about how these therapies influence microRNA (miRNA) expression, particular...

    Authors: Aubrey G Wagenseller, Amber Shada, Kevin M D’Auria, Cheryl Murphy, Dandan Sun, Kerrington R Molhoek, Jason A Papin, Anindya Dutta and Craig L Slingluff Jr
    Citation: Journal of Translational Medicine 2013 11:218
    Content type: Research Published on:

  29. T-cell immunoglobulin and mucin domain 3 (TIM-3) is known as a negative immune regulator and emerging data have implicated TIM-3 a pivotal role in suppressing antitumor immunity. The co-stimulatory receptor CD...

    Authors: Zhiqiang Guo, Dali Cheng, Zhijun Xia, Meng Luan, Liangliang Wu, Gang Wang and Shulan Zhang
    Citation: Journal of Translational Medicine 2013 11:215
    Content type: Research Published on:

  30. Ultraviolet-inactivated, replication-defective Sendai virus particles (Z strain) have displayed antitumor effect through enhancing the immune responses or inducing apoptosis in a variety of carcinomas. Sendai ...

    Authors: Liying Shi, Jun Chen, Qiping Zhong, Mei Li, Peng Geng, Jianmin He, Zhe Han, Mingwei Sheng and Hua Tang
    Citation: Journal of Translational Medicine 2013 11:205
    Content type: Research Published on:

  31. Malignant pleural mesothelioma (MPM) is an incurable malignant disease, which results from chronic exposition to asbestos in at least 70% of the cases. Fibroblast activation protein (FAP) is predominantly expr...

    Authors: Petra C Schuberth, Christian Hagedorn, Shawn M Jensen, Pratiksha Gulati, Maries van den Broek, Axel Mischo, Alex Soltermann, Astrid Jüngel, Osiris Marroquin Belaunzaran, Rolf Stahel, Christoph Renner and Ulf Petrausch
    Citation: Journal of Translational Medicine 2013 11:187
    Content type: Research Published on:

  32. Natural killer (NK) cells can kill tumor cells in a non-MHC-restricted manner. However, cancer cells frequently escape from the attack of NK cells by multiple ways. In this study, we investigated the effect of...

    Authors: Sisi He, Tao Yin, Dan Li, Xiang Gao, Yang Wan, Xuelei Ma, Tinghong Ye, Fuchun Guo, Jianhong Sun, Ziqiang Lin and Yongsheng Wang
    Citation: Journal of Translational Medicine 2013 11:186
    Content type: Research Published on:

  33. mRNA electroporation of dendritic cells (DCs) facilitates processing and presentation of multiple peptides derived from whole antigen, tailored to different HLA molecules. Clinical responses to electroporated ...

    Authors: David J Chung, Emanuela Romano, Katherine B Pronschinske, Justin A Shyer, Milena Mennecozzi, Erin T St Angelo and James W Young
    Citation: Journal of Translational Medicine 2013 11:166
    Content type: Methodology Published on:

  34. New treatment modalities are needed for the treatment of cancers of the head and neck region (HNSCC). Survivin is important for the survival and proliferation of tumor cells and may therefore provide a target ...

    Authors: Annelies W Turksma, Hetty J Bontkes, Janneke J Ruizendaal, Kirsten BJ Scholten, Johanneke Akershoek, Shakila Rampersad, Laura M Moesbergen, Saskia AGM Cillessen, Saskia JAM Santegoets, Tanja D de Gruijl, C René Leemans, Chris JLM Meijer and Erik Hooijberg
    Citation: Journal of Translational Medicine 2013 11:152
    Content type: Research Published on:

  35. A promising cancer vaccine involves the fusion of tumor cells with dendritic cells (DCs). As such, a broad spectrum of both known and unidentified tumor antigens is presented to the immune system in the contex...

    Authors: Chunrui Tan, Varun Reddy, Jens Dannull, Enyu Ding, Smita K Nair, Douglas S Tyler, Scott K Pruitt and Walter T Lee
    Citation: Journal of Translational Medicine 2013 11:148
    Content type: Research Published on:

  36. In cancer immunotherapy, dendritic cells (DCs) play a fundamental role in the dialog between innate and adaptive immune response, but several immunosuppressive mechanisms remain to be overcome. For example, a ...

    Authors: Laura Ridolfi, Massimiliano Petrini, Anna Maria Granato, Giusy Gentilcore, Ester Simeone, Paolo Antonio Ascierto, Elena Pancisi, Valentina Ancarani, Laura Fiammenghi, Massimo Guidoboni, Francesco de Rosa, Linda Valmorri, Emanuela Scarpi, Stefania Vittoria Luisa Nicoletti, Stefano Baravelli, Angela Riccobon…
    Citation: Journal of Translational Medicine 2013 11:135
    Content type: Research Published on:

  37. Deceased after cardiac arrest donor are an additional source of kidney graft to overcome graft shortage. Deciphering the respective role of renal warm and cold ischemia is of pivotal interest in the transplant...

    Authors: Ludivine Rossard, Frédéric Favreau, Sebastien Giraud, Raphael Thuillier, Sylvain Le Pape, Jean Michel Goujon, Alexandre Valagier and Thierry Hauet
    Citation: Journal of Translational Medicine 2013 11:129
    Content type: Research Published on:

  38. Generation of tolerogenic dendritic cells (TolDCs) for therapy is challenging due to its implications for the design of protocols suitable for clinical applications, which means not only using safe products, b...

    Authors: Paulina García-González, Rodrigo Morales, Lorena Hoyos, Jaxaira Maggi, Javier Campos, Bárbara Pesce, David Gárate, Milton Larrondo, Rodrigo González, Lilian Soto, Verónica Ramos, Pía Tobar, María Carmen Molina, Karina Pino-Lagos, Diego Catalán and Juan Carlos Aguillón
    Citation: Journal of Translational Medicine 2013 11:128
    Content type: Research Published on:

  39. Primary testicular lymphoma (PTL) is a rare and lethal disease. The most common histological subtype is diffuse large B-cell lymphoma (DLBCL). Standard treatments are frequently ineffective. Thus, the developm...

    Authors: Tvrtko Hudolin, Zeljko Kastelan, Ivana Ilic, Katarina Levarda-Hudolin, Nikolina Basic-Jukic, Malte Rieken, Giulio C Spagnoli, Antonio Juretic and Chantal Mengus
    Citation: Journal of Translational Medicine 2013 11:123
    Content type: Research Published on:

  40. CTLA-4 (Cytotoxic T lymphocyte antigen-4) is traditionally known as a negative regulator of T cell activation. The blocking of CTLA-4 using human monoclonal antibodies, such as Ipilimumab, is currently used to...

    Authors: Stefania Laurent, Paola Queirolo, Silvia Boero, Sandra Salvi, Patrizia Piccioli, Simona Boccardo, Simona Minghelli, Anna Morabito, Vincenzo Fontana, Gabriella Pietra, Paolo Carrega, Nicoletta Ferrari, Francesca Tosetti, Lung-Ji Chang, Maria Cristina Mingari, Guido Ferlazzo…
    Citation: Journal of Translational Medicine 2013 11:108
    Content type: Research Published on:

  41. Malignant pleural effusion (MPE) is associated with advanced stages of lung cancer and is mainly dependent on invasion of the pleura and expression of vascular endothelial growth factor (VEGF) by cancer cells....

    Authors: Stephanie Weibel, Elisabeth Hofmann, Thomas Christian Basse-Luesebrink, Ulrike Donat, Carolin Seubert, Marion Adelfinger, Prisca Gnamlin, Christina Kober, Alexa Frentzen, Ivaylo Gentschev, Peter Michael Jakob and Aladar A Szalay
    Citation: Journal of Translational Medicine 2013 11:106
    Content type: Research Published on:

  42. Vaccine treatment using multiple peptides derived from multiple proteins is considered to be a promising option for cancer immune therapy, but scientific evidence supporting the therapeutic efficacy of multipl...

    Authors: Hiroyuki Suzuki, Mitsuro Fukuhara, Takumi Yamaura, Satoshi Mutoh, Naoyuki Okabe, Hiroshi Yaginuma, Takeo Hasegawa, Atsushi Yonechi, Jun Osugi, Mika Hoshino, Takashi Kimura, Mitsunori Higuchi, Yutaka Shio, Kazuya Ise, Kazuyoshi Takeda and Mitsukazu Gotoh
    Citation: Journal of Translational Medicine 2013 11:97
    Content type: Research Published on:

  43. The FDA recently approved an anti-CTLA-4 antibody (Iplimumab) for the treatment of metastatic melanoma. This decision was based on Phase III results, which demonstrate that blocking this immune checkpoint prov...

    Authors: Satoshi Wada, Christopher M Jackson, Kiyoshi Yoshimura, Hung-Rong Yen, Derese Getnet, Timothy J Harris, Monica V Goldberg, Tullia C Bruno, Joseph F Grosso, Nicholas Durham, George J Netto, Drew M Pardoll and Charles G Drake
    Citation: Journal of Translational Medicine 2013 11:89
    Content type: Research Published on:

  44. The number of immune cells, especially dendritic cells and cytotoxic tumor infiltrating lymphocytes (TIL), particularly Th1 cells, CD8 T cells, and NK cells is associated with increased survival of cancer pati...

    Authors: Jingting Jiang, Changping Wu and Binfeng Lu
    Citation: Journal of Translational Medicine 2013 11:83
    Content type: Review Published on:

  45. Despite availability of efficient treatment regimens for early stage colorectal cancer, treatment regimens for late stage colorectal cancer are generally not effective and thus need improvement. Oncolytic viro...

    Authors: Klaas Ehrig, Mehmet O Kilinc, Nanhai G Chen, Jochen Stritzker, Lisa Buckel, Qian Zhang and Aladar A Szalay
    Citation: Journal of Translational Medicine 2013 11:79
    Content type: Research Published on:

  46. CD8+ T cells are key members of adaptive immunity against tumorigenesis. As subset of CD8+ T cells, effector T cells (Te) and memory T cells (Tm) have different biological activities. The former can kill tumor...

    Authors: Guocheng Zhong, Xiaoming Cheng, Haixia Long, Luhang He, Wei Qi, Tong Xiang, Zhongquan Zhao and Bo Zhu
    Citation: Journal of Translational Medicine 2013 11:71
    Content type: Research Published on:

  47. L-BLP25 antigen-specific cancer immunotherapeutic agent is currently in phase III clinical trials for non-small cell lung cancer. Using a novel human MUC1 transgenic (hMUC1.Tg) lung cancer mouse model, we eval...

    Authors: Gregory T Wurz, Audrey M Gutierrez, Brittany E Greenberg, Daniel P Vang, Stephen M Griffey, Chiao-Jung Kao, Michael Wolf and Michael W DeGregorio
    Citation: Journal of Translational Medicine 2013 11:64
    Content type: Research Published on:

  48. Imatinib mesylate is an effective treatment for metastatic gastrointestinal stromal tumor (GIST). However, most patients eventually develop resistance and there are few other treatment options. Immunotherapy u...

    Authors: Steven C Katz, Rachel A Burga, Seema Naheed, Lauren A Licata, Mitchell Thorn, Doreen Osgood, Cang T Nguyen, N Joseph Espat, Jonathan A Fletcher and Richard P Junghans
    Citation: Journal of Translational Medicine 2013 11:46
    Content type: Research Published on:

  49. The sixth leading class of cancer worldwide is head and neck cancer, which typically arise within the squamous epithelium of the oral mucosa. Human head and neck squamous cell carcinoma (HNSCC) is known to be ...

    Authors: Bradford Hall, Hideyuki Nakashima, Zhi-Jun Sun, Yuki Sato, Yansong Bian, Syed R Husain, Raj K Puri and Ashok B Kulkarni
    Citation: Journal of Translational Medicine 2013 11:45
    Content type: Research Published on:

  50. Besides being a preferential site of early metastasis, the sentinel lymph node (SLN) is also a privileged site of T-cell priming, and may thus be an appropriate target for investigating cell types involved in ...

    Authors: Anita Mohos, Tímea Sebestyén, Gabriella Liszkay, Vanda Plótár, Szabolcs Horváth, István Gaudi and Andrea Ladányi
    Citation: Journal of Translational Medicine 2013 11:43
    Content type: Research Published on:
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