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Immunobiology and immunotherapy

Section edited by Alessandra Cesano

This section aims to enrich the communication between basic biological and immunological sciences and the clinical investigation arena.

As immunology has evolved to be a central discipline connected to a wide range of therapeutic areas, the number and diversity of platform technologies has also increased, spanning small molecules, biologics, microbial vectors and cells. Such levels of activity require appropriate means to share new knowledge and to catalyze the development of the field. This section aims to provide such a platform and welcomes submissions across all disciplines, including inflammation, autoimmunity, transplantation, metabolic disorders.

The section was founded with the Society for Immunotherapy of Cancer (SITC) under the title "Tumor immunology and biological cancer therapy" and Edited by Pedro Romero.

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  1. For thousands of years, it remains unclear why Chinese prefer complex herbal remedy and seldom try to purify it. One of the reasons is that they believe Chinese herbs compared to Western drugs are relatively l...

    Authors: Ling-Jun Ho, Wen-Liang Chang, Ann Chen, Ping Chao and Jenn-Haung Lai

    Citation: Journal of Translational Medicine 2013 11:294

    Content type: Research

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  2. We previously developed an immunotherapy treatment utilizing a cancer vaccine reagent KIF20A-66 in order to treat pancreatic cancer. KIF20A-66 is HLA-A24-restricted epitope peptide derived from KIF20A, a membe...

    Authors: Shingo Asahara, Kazuyoshi Takeda, Kenji Yamao, Hiroyuki Maguchi and Hiroki Yamaue

    Citation: Journal of Translational Medicine 2013 11:291

    Content type: Research

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  3. The capacity of patient’s Natural Killer cells (NKs) to be activated for cytolysis is an important prerequisite for the success of antibody-derived agents such as single-chain triplebodies (triplebodies) in ca...

    Authors: Todd A Braciak, Sarah Wildenhain, Claudia C Roskopf, Ingo A Schubert, Georg H Fey, Uwe Jacob, Karl-Peter Hopfner and Fuat S Oduncu

    Citation: Journal of Translational Medicine 2013 11:289

    Content type: Research

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  4. Both apoptosis and autoantibodies are important factors associated with disease activity in the pathogenesis of systemic lupus erythematosus (SLE). This study tested the hypothesis that increased leukocyte apo...

    Authors: Yu-Jih Su, Tien-Tsai Cheng, Chung-Jen Chen, Wen-Chan Chiu, Chung-Yuan Hsu, Wen-Neng Chang, Nai-Wen Tsai, Chia-Te Kung, Hung-Chen Wang, Wei-Che Lin, Chih-Cheng Huang, Ya-Ting Chang, Chih-Min Su, Yi-Fang Chiang, Ben-Chung Cheng, Yu-Jun Lin…

    Citation: Journal of Translational Medicine 2013 11:261

    Content type: Research

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  5. HLA abnormalities on tumour cells for immune escape have been widely described. In addition, cellular components of the tumour microenvironment, in particular myeloid derived suppressor cells (MDSC) and altern...

    Authors: Maddalena Marchesi, Emilia Andersson, Lisa Villabona, Barbara Seliger, Andreas Lundqvist, Rolf Kiessling and Giuseppe V Masucci

    Citation: Journal of Translational Medicine 2013 11:247

    Content type: Review

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  6. Cholesteryl pullulan (CHP) is a novel antigen delivery system for cancer vaccines. This study evaluated the safety, immune responses and clinical outcomes of patients who received the CHP-NY-ESO-1 complex vacc...

    Authors: Shinichi Kageyama, Hisashi Wada, Kei Muro, Yasumasa Niwa, Shugo Ueda, Hiroshi Miyata, Shuji Takiguchi, Sahoko H Sugino, Yoshihiro Miyahara, Hiroaki Ikeda, Naoko Imai, Eiichi Sato, Tomomi Yamada, Masaharu Osako, Mami Ohnishi, Naozumi Harada…

    Citation: Journal of Translational Medicine 2013 11:246

    Content type: Research

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  7. As organ shortage is increasing, the acceptance of marginal donors increases, which might result in poor organ function and patient survival. Mostly, organ damage is caused during brain death (BD), cold ischem...

    Authors: Philipp Stiegler, Michael Sereinigg, Andreas Puntschart, Andrea Bradatsch, Thomas Seifert-Held, Iris Wiederstein-Grasser, Bettina Leber, Elke Stadelmeyer, Nadia Dandachi, Siglinde Zelzer, Florian Iberer and Vanessa Stadlbauer

    Citation: Journal of Translational Medicine 2013 11:244

    Content type: Research

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  8. Dendritic cells (DCs) are important mediators of anti-tumor immune responses. We hypothesized that an in-depth analysis of dendritic cells and their spatial relationships to each other as well as to other immu...

    Authors: Andrew Y Chang, Nupur Bhattacharya, Jian Mu, A Francesca Setiadi, Valeria Carcamo-Cavazos, Gerald H Lee, Diana L Simons, Sina Yadegarynia, Kaveh Hemati, Adam Kapelner, Zheng Ming, David N Krag, Erich J Schwartz, Danny Z Chen and Peter P Lee

    Citation: Journal of Translational Medicine 2013 11:242

    Content type: Research

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  9. In this study, we developed a pharmacokinetic (PK)- pharmacodynamic (PD) model of a new sustained release formulation of interferon-α-2a (SR-IFN-α) using the blood concentration of IFN-α and neopterin in order...

    Authors: Sangil Jeon, Jae-Hyeon Juhn, Seunghoon Han, Jongtae Lee, Taegon Hong, Jeongki Paek and Dong-Seok Yim

    Citation: Journal of Translational Medicine 2013 11:240

    Content type: Research

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  10. Alveolar soft part sarcoma (ASPS) is a rare soft tissue sarcoma and the clinical management of patients with unresectable, metastatic disease is still challenging. ASPS expresses an array of potentially therap...

    Authors: Chiara Castelli, Marcella Tazzari, Tiziana Negri, Barbara Vergani, Licia Rivoltini, Silvia Stacchiotti and Silvana Pilotti

    Citation: Journal of Translational Medicine 2013 11:237

    Content type: Commentary

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  11. Azathiopurine (AZA) is efficacious for maintenance remission of Crohn’s disease (CD) at the standard dose of 2.0-2.5 mg/kg for Caucasian. It has been reported that the lower dose (1.0-2.0 mg/kg) in some Asian ...

    Authors: Jianghong Wu, Yan Gao, Chuanhua Yang, Xueqing Yang, Xuhang Li and Shudong Xiao

    Citation: Journal of Translational Medicine 2013 11:235

    Content type: Research

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  12. Resistin increases during several inflammatory diseases and after intracerebral bleeding or head trauma. Resistin activates the endothelium and may initiate an inflammatory response. No data are available on r...

    Authors: Simona Oltean, Rille Pullerits, Anne Flodén, Michael Olausson and Mihai Oltean

    Citation: Journal of Translational Medicine 2013 11:233

    Content type: Research

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  13. Primary cutaneous lymphomas (CLs), characterized by an accumulation of clonal T or B lymphocytes preferentially localized in the skin, have been successfully treated with interferons (IFNs) which counterbalanc...

    Authors: Nathalie Accart, Mirjana Urosevic-Maiwald, Reinhard Dummer, Vincent Bataille, Nadine Kehrer, Cristina Niculescu, Jean-Marc Limacher, Marie-Pierre Chenard, Jean-Yves Bonnefoy and Ronald Rooke

    Citation: Journal of Translational Medicine 2013 11:226

    Content type: Research

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  14. Antibodies binding to citrullinated proteins are a frequent finding in rheumatoid arthritis patients and may precede the onset of clinical symptoms several years. The antibodies are a predisposing factor for b...

    Authors: Sanna Turunen, Marja-Kaisa Koivula, Jukka Melkko, Eeva Alasaarela, Petri Lehenkari and Juha Risteli

    Citation: Journal of Translational Medicine 2013 11:224

    Content type: Research

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  15. Targeted therapies directed at commonly overexpressed pathways in melanoma have clinical activity in numerous trials. Little is known about how these therapies influence microRNA (miRNA) expression, particular...

    Authors: Aubrey G Wagenseller, Amber Shada, Kevin M D’Auria, Cheryl Murphy, Dandan Sun, Kerrington R Molhoek, Jason A Papin, Anindya Dutta and Craig L Slingluff Jr

    Citation: Journal of Translational Medicine 2013 11:218

    Content type: Research

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  16. T-cell immunoglobulin and mucin domain 3 (TIM-3) is known as a negative immune regulator and emerging data have implicated TIM-3 a pivotal role in suppressing antitumor immunity. The co-stimulatory receptor CD...

    Authors: Zhiqiang Guo, Dali Cheng, Zhijun Xia, Meng Luan, Liangliang Wu, Gang Wang and Shulan Zhang

    Citation: Journal of Translational Medicine 2013 11:215

    Content type: Research

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  17. Ultraviolet-inactivated, replication-defective Sendai virus particles (Z strain) have displayed antitumor effect through enhancing the immune responses or inducing apoptosis in a variety of carcinomas. Sendai ...

    Authors: Liying Shi, Jun Chen, Qiping Zhong, Mei Li, Peng Geng, Jianmin He, Zhe Han, Mingwei Sheng and Hua Tang

    Citation: Journal of Translational Medicine 2013 11:205

    Content type: Research

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  18. Malignant pleural mesothelioma (MPM) is an incurable malignant disease, which results from chronic exposition to asbestos in at least 70% of the cases. Fibroblast activation protein (FAP) is predominantly expr...

    Authors: Petra C Schuberth, Christian Hagedorn, Shawn M Jensen, Pratiksha Gulati, Maries van den Broek, Axel Mischo, Alex Soltermann, Astrid Jüngel, Osiris Marroquin Belaunzaran, Rolf Stahel, Christoph Renner and Ulf Petrausch

    Citation: Journal of Translational Medicine 2013 11:187

    Content type: Research

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  19. Natural killer (NK) cells can kill tumor cells in a non-MHC-restricted manner. However, cancer cells frequently escape from the attack of NK cells by multiple ways. In this study, we investigated the effect of...

    Authors: Sisi He, Tao Yin, Dan Li, Xiang Gao, Yang Wan, Xuelei Ma, Tinghong Ye, Fuchun Guo, Jianhong Sun, Ziqiang Lin and Yongsheng Wang

    Citation: Journal of Translational Medicine 2013 11:186

    Content type: Research

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  20. mRNA electroporation of dendritic cells (DCs) facilitates processing and presentation of multiple peptides derived from whole antigen, tailored to different HLA molecules. Clinical responses to electroporated ...

    Authors: David J Chung, Emanuela Romano, Katherine B Pronschinske, Justin A Shyer, Milena Mennecozzi, Erin T St Angelo and James W Young

    Citation: Journal of Translational Medicine 2013 11:166

    Content type: Methodology

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  21. New treatment modalities are needed for the treatment of cancers of the head and neck region (HNSCC). Survivin is important for the survival and proliferation of tumor cells and may therefore provide a target ...

    Authors: Annelies W Turksma, Hetty J Bontkes, Janneke J Ruizendaal, Kirsten BJ Scholten, Johanneke Akershoek, Shakila Rampersad, Laura M Moesbergen, Saskia AGM Cillessen, Saskia JAM Santegoets, Tanja D de Gruijl, C René Leemans, Chris JLM Meijer and Erik Hooijberg

    Citation: Journal of Translational Medicine 2013 11:152

    Content type: Research

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  22. A promising cancer vaccine involves the fusion of tumor cells with dendritic cells (DCs). As such, a broad spectrum of both known and unidentified tumor antigens is presented to the immune system in the contex...

    Authors: Chunrui Tan, Varun Reddy, Jens Dannull, Enyu Ding, Smita K Nair, Douglas S Tyler, Scott K Pruitt and Walter T Lee

    Citation: Journal of Translational Medicine 2013 11:148

    Content type: Research

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  23. In cancer immunotherapy, dendritic cells (DCs) play a fundamental role in the dialog between innate and adaptive immune response, but several immunosuppressive mechanisms remain to be overcome. For example, a ...

    Authors: Laura Ridolfi, Massimiliano Petrini, Anna Maria Granato, Giusy Gentilcore, Ester Simeone, Paolo Antonio Ascierto, Elena Pancisi, Valentina Ancarani, Laura Fiammenghi, Massimo Guidoboni, Francesco de Rosa, Linda Valmorri, Emanuela Scarpi, Stefania Vittoria Luisa Nicoletti, Stefano Baravelli, Angela Riccobon…

    Citation: Journal of Translational Medicine 2013 11:135

    Content type: Research

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  24. Deceased after cardiac arrest donor are an additional source of kidney graft to overcome graft shortage. Deciphering the respective role of renal warm and cold ischemia is of pivotal interest in the transplant...

    Authors: Ludivine Rossard, Frédéric Favreau, Sebastien Giraud, Raphael Thuillier, Sylvain Le Pape, Jean Michel Goujon, Alexandre Valagier and Thierry Hauet

    Citation: Journal of Translational Medicine 2013 11:129

    Content type: Research

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  25. Generation of tolerogenic dendritic cells (TolDCs) for therapy is challenging due to its implications for the design of protocols suitable for clinical applications, which means not only using safe products, b...

    Authors: Paulina García-González, Rodrigo Morales, Lorena Hoyos, Jaxaira Maggi, Javier Campos, Bárbara Pesce, David Gárate, Milton Larrondo, Rodrigo González, Lilian Soto, Verónica Ramos, Pía Tobar, María Carmen Molina, Karina Pino-Lagos, Diego Catalán and Juan Carlos Aguillón

    Citation: Journal of Translational Medicine 2013 11:128

    Content type: Research

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  26. Primary testicular lymphoma (PTL) is a rare and lethal disease. The most common histological subtype is diffuse large B-cell lymphoma (DLBCL). Standard treatments are frequently ineffective. Thus, the developm...

    Authors: Tvrtko Hudolin, Zeljko Kastelan, Ivana Ilic, Katarina Levarda-Hudolin, Nikolina Basic-Jukic, Malte Rieken, Giulio C Spagnoli, Antonio Juretic and Chantal Mengus

    Citation: Journal of Translational Medicine 2013 11:123

    Content type: Research

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  27. CTLA-4 (Cytotoxic T lymphocyte antigen-4) is traditionally known as a negative regulator of T cell activation. The blocking of CTLA-4 using human monoclonal antibodies, such as Ipilimumab, is currently used to...

    Authors: Stefania Laurent, Paola Queirolo, Silvia Boero, Sandra Salvi, Patrizia Piccioli, Simona Boccardo, Simona Minghelli, Anna Morabito, Vincenzo Fontana, Gabriella Pietra, Paolo Carrega, Nicoletta Ferrari, Francesca Tosetti, Lung-Ji Chang, Maria Cristina Mingari, Guido Ferlazzo…

    Citation: Journal of Translational Medicine 2013 11:108

    Content type: Research

    Published on:

  28. Malignant pleural effusion (MPE) is associated with advanced stages of lung cancer and is mainly dependent on invasion of the pleura and expression of vascular endothelial growth factor (VEGF) by cancer cells....

    Authors: Stephanie Weibel, Elisabeth Hofmann, Thomas Christian Basse-Luesebrink, Ulrike Donat, Carolin Seubert, Marion Adelfinger, Prisca Gnamlin, Christina Kober, Alexa Frentzen, Ivaylo Gentschev, Peter Michael Jakob and Aladar A Szalay

    Citation: Journal of Translational Medicine 2013 11:106

    Content type: Research

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  29. Vaccine treatment using multiple peptides derived from multiple proteins is considered to be a promising option for cancer immune therapy, but scientific evidence supporting the therapeutic efficacy of multipl...

    Authors: Hiroyuki Suzuki, Mitsuro Fukuhara, Takumi Yamaura, Satoshi Mutoh, Naoyuki Okabe, Hiroshi Yaginuma, Takeo Hasegawa, Atsushi Yonechi, Jun Osugi, Mika Hoshino, Takashi Kimura, Mitsunori Higuchi, Yutaka Shio, Kazuya Ise, Kazuyoshi Takeda and Mitsukazu Gotoh

    Citation: Journal of Translational Medicine 2013 11:97

    Content type: Research

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  30. The FDA recently approved an anti-CTLA-4 antibody (Iplimumab) for the treatment of metastatic melanoma. This decision was based on Phase III results, which demonstrate that blocking this immune checkpoint prov...

    Authors: Satoshi Wada, Christopher M Jackson, Kiyoshi Yoshimura, Hung-Rong Yen, Derese Getnet, Timothy J Harris, Monica V Goldberg, Tullia C Bruno, Joseph F Grosso, Nicholas Durham, George J Netto, Drew M Pardoll and Charles G Drake

    Citation: Journal of Translational Medicine 2013 11:89

    Content type: Research

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  31. The number of immune cells, especially dendritic cells and cytotoxic tumor infiltrating lymphocytes (TIL), particularly Th1 cells, CD8 T cells, and NK cells is associated with increased survival of cancer pati...

    Authors: Jingting Jiang, Changping Wu and Binfeng Lu

    Citation: Journal of Translational Medicine 2013 11:83

    Content type: Review

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  32. Despite availability of efficient treatment regimens for early stage colorectal cancer, treatment regimens for late stage colorectal cancer are generally not effective and thus need improvement. Oncolytic viro...

    Authors: Klaas Ehrig, Mehmet O Kilinc, Nanhai G Chen, Jochen Stritzker, Lisa Buckel, Qian Zhang and Aladar A Szalay

    Citation: Journal of Translational Medicine 2013 11:79

    Content type: Research

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  33. CD8+ T cells are key members of adaptive immunity against tumorigenesis. As subset of CD8+ T cells, effector T cells (Te) and memory T cells (Tm) have different biological activities. The former can kill tumor...

    Authors: Guocheng Zhong, Xiaoming Cheng, Haixia Long, Luhang He, Wei Qi, Tong Xiang, Zhongquan Zhao and Bo Zhu

    Citation: Journal of Translational Medicine 2013 11:71

    Content type: Research

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  34. L-BLP25 antigen-specific cancer immunotherapeutic agent is currently in phase III clinical trials for non-small cell lung cancer. Using a novel human MUC1 transgenic (hMUC1.Tg) lung cancer mouse model, we eval...

    Authors: Gregory T Wurz, Audrey M Gutierrez, Brittany E Greenberg, Daniel P Vang, Stephen M Griffey, Chiao-Jung Kao, Michael Wolf and Michael W DeGregorio

    Citation: Journal of Translational Medicine 2013 11:64

    Content type: Research

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  35. Imatinib mesylate is an effective treatment for metastatic gastrointestinal stromal tumor (GIST). However, most patients eventually develop resistance and there are few other treatment options. Immunotherapy u...

    Authors: Steven C Katz, Rachel A Burga, Seema Naheed, Lauren A Licata, Mitchell Thorn, Doreen Osgood, Cang T Nguyen, N Joseph Espat, Jonathan A Fletcher and Richard P Junghans

    Citation: Journal of Translational Medicine 2013 11:46

    Content type: Research

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  36. The sixth leading class of cancer worldwide is head and neck cancer, which typically arise within the squamous epithelium of the oral mucosa. Human head and neck squamous cell carcinoma (HNSCC) is known to be ...

    Authors: Bradford Hall, Hideyuki Nakashima, Zhi-Jun Sun, Yuki Sato, Yansong Bian, Syed R Husain, Raj K Puri and Ashok B Kulkarni

    Citation: Journal of Translational Medicine 2013 11:45

    Content type: Research

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  37. Besides being a preferential site of early metastasis, the sentinel lymph node (SLN) is also a privileged site of T-cell priming, and may thus be an appropriate target for investigating cell types involved in ...

    Authors: Anita Mohos, Tímea Sebestyén, Gabriella Liszkay, Vanda Plótár, Szabolcs Horváth, István Gaudi and Andrea Ladányi

    Citation: Journal of Translational Medicine 2013 11:43

    Content type: Research

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  38. Adoptive cell transfer of tumor infiltrating lymphocytes has shown clinical efficacy in the treatment of melanoma and is now also being explored in other tumor types. Generation of sufficient numbers of effect...

    Authors: Saskia JAM Santegoets, Annelies W Turksma, Megan M Suhoski, Anita GM Stam, Steve M Albelda, Erik Hooijberg, Rik J Scheper, Alfons JM van den Eertwegh, Winald R Gerritsen, Daniel J Powell Jr, Carl H June and Tanja D de Gruijl

    Citation: Journal of Translational Medicine 2013 11:37

    Content type: Research

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  39. Hirsutanol A is a novel sesquiterpene compound purified from fungus Chondrostereum sp. in Sarcophyton tortuosum. Our previous studies had demonstrated that hirsutanol A exhibited potent cytotoxic effect on many k...

    Authors: Fen Yang, Wen-Dan Chen, Rong Deng, Hui Zhang, Jun Tang, Ke-Wei Wu, Dan-Dan Li, Gong-Kan Feng, Wen-Jian Lan, Hou-Jin Li and Xiao-Feng Zhu

    Citation: Journal of Translational Medicine 2013 11:32

    Content type: Research

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  40. MicroRNAs (miRNAs) are small (19-22-nt) single-stranded noncoding RNA molecules whose deregulation of expression can contribute to human disease including the multistep processes of carcinogenesis in human. Ci...

    Authors: Hussein Fayyad-Kazan, Nizar Bitar, Mehdi Najar, Philippe Lewalle, Mohammad Fayyad-Kazan, Rabih Badran, Eva Hamade, Ahmad Daher, Nader Hussein, Rim ELDirani, Fadwa Berri, Luc Vanhamme, Arsène Burny, Philippe Martiat, Redouane Rouas and Bassam Badran

    Citation: Journal of Translational Medicine 2013 11:31

    Content type: Research

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  41. Natural Killer (NK) cells are known to reject several experimental murine tumors, but their antineoplastic activity in humans is not generally agreed upon, as exemplified by an interesting correspondence recen...

    Authors: Doriana Fruci, Elisa Lo Monaco, Loredana Cifaldi, Franco Locatelli, Elisa Tremante, Maria Benevolo and Patrizio Giacomini

    Citation: Journal of Translational Medicine 2013 11:30

    Content type: Commentary

    Published on:

  42. Chimeric Antigen Receptors (CARs) consist of the antigen-recognition portion of a monoclonal antibody fused to an intracellular signaling domain capable of activating T-cells. CARs displayed on the surface of ...

    Authors: Satiro N De Oliveira, Jiexin Wang, Christine Ryan, Sherie L Morrison, Donald B Kohn and Roger P Hollis

    Citation: Journal of Translational Medicine 2013 11:23

    Content type: Methodology

    Published on:

  43. EMD 521873 (Selectikine or NHS-IL2LT) is a fusion protein consisting of modified human IL-2 which binds specifically to the high-affinity IL-2 receptor, and an antibody specific for both single- and double-str...

    Authors: Julien Laurent, Cedric Touvrey, Silke Gillessen, Magali Joffraud, Manuela Vicari, Caroline Bertrand, Stefano Ongarello, Bernd Liedert, Elisa Gallerani, Joachim Beck, Aurelius Omlin, Cristiana Sessa, Sonia Quaratino, Roger Stupp, Ulrike S Gnad-Vogt and Daniel E Speiser

    Citation: Journal of Translational Medicine 2013 11:5

    Content type: Research

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  44. Multiple myeloma (MM) is a plasma cell malignancy with a multifaceted immune dysfunction. Indoleamine 2,3-dioxygenase 1 (IDO1) degrades tryptophan into kynurenine (KYN), which inhibits effector T cells and pro...

    Authors: Giuseppina Bonanno, Andrea Mariotti, Annabella Procoli, Valentina Folgiero, Daniela Natale, Luca De Rosa, Ignazio Majolino, Linda Novarese, Alberto Rocci, Manuela Gambella, Marilena Ciciarello, Giovanni Scambia, Antonio Palumbo, Franco Locatelli, Raimondo De Cristofaro and Sergio Rutella

    Citation: Journal of Translational Medicine 2012 10:247

    Content type: Research

    Published on:

  45. Multiple farnesylated proteins are involved in signal transduction in cancer. Farnesyltransferase inhibitors (FTIs) have been developed as a strategy to inhibit the function of these proteins. As FTIs inhibit ...

    Authors: Thomas F Gajewski, April KS Salama, Donna Niedzwiecki, Jeffrey Johnson, Gerald Linette, Cynthia Bucher, Michelle A Blaskovich, Said M Sebti and Frank Haluska

    Citation: Journal of Translational Medicine 2012 10:246

    Content type: Research

    Published on:

  46. CTLA4 blocking monoclonal antibodies provide a low frequency but durable tumor responses in patients with metastatic melanoma, which led to the regulatory approval of ipilimumab based on two randomized clinica...

    Authors: Antoni Ribas, Jason A Chesney, Michael S Gordon, Amy P Abernethy, Theodore F Logan, David H Lawson, Bartosz Chmielowksi, John A Glaspy, Karl Lewis, Bo Huang, Erjian Wang, Poe-Hirr Hsyu, Jesus Gomez-Navarro, Diana Gerhardt, Margaret A Marshall and Rene Gonzalez

    Citation: Journal of Translational Medicine 2012 10:236

    Content type: Research

    Published on:

  47. Anti-EGFR monoclonal antibodies have shown efficacy in the treatment of metastatic colorectal cancer (mCRC). One of the mechanism is the antibody-dependent cell-mediated cytotoxicity (ADCC) in which Fc region ...

    Authors: Rosa Calemma, Alessandro Ottaiano, Anna Maria Trotta, Guglielmo Nasti, Carmela Romano, Maria Napolitano, Domenico Galati, Pasquale Borrelli, Serena Zanotta, Antonino Cassata, Giuseppe Castello, Vincenzo Rosario Iaffaioli and Stefania Scala

    Citation: Journal of Translational Medicine 2012 10:232

    Content type: Research

    Published on:

  48. High-intensity focused-ultrasound (HIFU) has been successfully employed for thermal ablation of tumors in clinical settings. Continuous- or pulsed-mode HIFU may also induce a host antitumor immune response, ma...

    Authors: Hao-Li Liu, Han-Yi Hsieh, Li-An Lu, Chiao-Wen Kang, Ming-Fang Wu and Chun-Yen Lin

    Citation: Journal of Translational Medicine 2012 10:221

    Content type: Research

    Published on:

  49. Trifunctional bispecific antibodies (trAb) are a special class of bispecific molecules recruiting and activating T cells and accessory immune cells simultaneously at the targeted tumor. The new trAb Ektomab th...

    Authors: Peter Ruf, Beatrix Schäfer, Nina Eissler, Ralph Mocikat, Juergen Hess, Matthias Plöscher, Susanne Wosch, Ivonne Suckstorff, Christine Zehetmeier and Horst Lindhofer

    Citation: Journal of Translational Medicine 2012 10:219

    Content type: Research

    Published on:

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