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Immunobiology and Immunotherapy

Section edited by Alessandra Cesano

The Immunobiology and Immunotherapy section aims to enrich the communication between basic biological and immunological sciences and the clinical investigation arena.

As immunology has evolved to be a central discipline connected to a wide range of therapeutic areas, the number and diversity of platform technologies has also increased, spanning small molecules, biologics, microbial vectors and cells. Such levels of activity require appropriate means to share new knowledge and to catalyze the development of the field. This section aims to provide such a platform and welcomes submissions across all disciplines, including inflammation, autoimmunity, transplantation, metabolic disorders.

The section was founded with the Society for Immunotherapy of Cancer (SITC) under the title "Tumor immunology and biological cancer therapy" and Pedro Romero was the founding Section Editor.

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  1. Chronic fatigue syndrome (CFS) is a prevalent and disabling condition among adolescent. The disease mechanisms are unknown. Previous studies have suggested elevated plasma levels of several cytokines, but a re...

    Authors: Vegard Bruun Wyller, Chinh Bkrong Nguyen, Judith Anita Ludviksen and Tom Eirik Mollnes
    Citation: Journal of Translational Medicine 2017 15:245
  2. Understanding immune phenotypes and human gastric disease in situ requires an approach that leverages multiplexed immunohistochemistry (mIHC) with multispectral imaging to facilitate precise image analyses.

    Authors: Le Ying, Feng Yan, Qiaohong Meng, Xiangliang Yuan, Liang Yu, Bryan R. G. Williams, David W. Chan, Liyun Shi, Yugang Tu, Peihua Ni, Xuefeng Wang, Dakang Xu and Yiqun Hu
    Citation: Journal of Translational Medicine 2017 15:206
  3. The complex interactions between the immune system and tumors lead the identification of key molecules that govern these interactions: immunotherapeutics were designed to overcome the mechanisms broken by tumo...

    Authors: Paolo A. Ascierto, Bruno Daniele, Hans Hammers, Vera Hirsh, Joseph Kim, Lisa Licitra, Rita Nanda and Sandro Pignata
    Citation: Journal of Translational Medicine 2017 15:205
  4. The current BCG vaccine induces only short-term protection against Mycobacterium tuberculosis (Mtb), suggesting its failure to generate long-lasting memory T cells. Previously, we have demonstrated that a self-ad...

    Authors: Pradeep K. Rai, Sathi Babu Chodisetti, Weiguang Zeng, Sajid Nadeem, Sudeep K. Maurya, Susanta Pahari, Ashok K. Janmeja, David C. Jackson and Javed N. Agrewala
    Citation: Journal of Translational Medicine 2017 15:201
  5. A small proportion of HIV-infected patients remain clinically and/or immunologically stable for years, including elite controllers (ECs) who have undetectable viremia (<50 copies/ml) and long-term nonprogresso...

    Authors: Le-Le Zhang, Zi-Ning Zhang, Xian Wu, Yong-Jun Jiang, Ya-Jing Fu and Hong Shang
    Citation: Journal of Translational Medicine 2017 15:191
  6. Our research is focused on using the vaccine draining lymph node to better understand the immune response to cancer vaccines and as a possible source of anti-cancer reagents. We evaluated vaccine draining lymp...

    Authors: Girja S. Shukla, Walter C. Olson, Stephanie C. Pero, Yu-jing Sun, Chelsea L. Carman, Craig L. Slingluff Jr. and David N. Krag
    Citation: Journal of Translational Medicine 2017 15:180
  7. The success of immunotherapeutics in oncology and the search for further improvements has prompted revisiting the use of cancer vaccines. In this context, knowledge of the immunogenic epitopes and the monitori...

    Authors: Tanja Scheikl-Gatard, Caroline Tosch, François Lemonnier and Ronald Rooke
    Citation: Journal of Translational Medicine 2017 15:154
  8. Thanks to striking progress in both the understanding of anti-tumor immune response and the characterization of several tumor associated antigens (TAA), a more rational design and more sophisticated strategies...

    Authors: Valeria Rolih, Giuseppina Barutello, Selina Iussich, Raffaella De Maria, Elena Quaglino, Paolo Buracco, Federica Cavallo and Federica Riccardo
    Citation: Journal of Translational Medicine 2017 15:151
  9. Immunotherapy consists of activating the patient’s immune system to fight cancer and has the great potential of preventing future relapses thanks to immunological memory. A great variety of strategies have eme...

    Authors: Michele Graciotti, Cristiana Berti, Harm-Anton Klok and Lana Kandalaft
    Citation: Journal of Translational Medicine 2017 15:142
  10. Recombinant monoclonal antibodies (mAbs) are one of today’s most successful therapeutic classes in inflammatory diseases and oncology. A wider accessibility and implementation, however, is hampered by the high...

    Authors: Kevin Hollevoet and Paul J. Declerck
    Citation: Journal of Translational Medicine 2017 15:131
  11. Invariant natural killer T (iNKT) cells are a small population of lymphocytes with unique specificity for glycolipid antigens presented by non-polymorphic CD1d receptor on dendritic cells (DCs). iNKT cells pla...

    Authors: Laura Escribà-Garcia, Carmen Alvarez-Fernández, Marta Tellez-Gabriel, Jorge Sierra and Javier Briones
    Citation: Journal of Translational Medicine 2017 15:115
  12. The spleen is a secondary lymphoid organ which can influence the progression of multiple diseases, notably liver cirrhosis. In chronic liver diseases, splenomegaly and hypersplenism can manifest following the ...

    Authors: Liang Li, Mubing Duan, Weisan Chen, An Jiang, Xiaoming Li, Jun Yang and Zongfang Li
    Citation: Journal of Translational Medicine 2017 15:111
  13. Prognosis of patients with glioblastoma multiforme (GBM) remains dismal, with median overall survival (OS) of about 15 months. It is therefore crucial to search alternative strategies that improve these result...

    Authors: Susana Inogés, Sonia Tejada, Ascensión López-Díaz de Cerio, Jaime Gállego Pérez-Larraya, Jaime Espinós, Miguel Angel Idoate, Pablo Daniel Domínguez, Reyes García de Eulate, Javier Aristu, Maurizio Bendandi, Fernando Pastor, Marta Alonso, Enrique Andreu, Felipe Prósper Cardoso and Ricardo Díez Valle
    Citation: Journal of Translational Medicine 2017 15:104
  14. Chronic fatigue syndrome (CFS) is a prevalent and disabling condition affecting adolescents. The pathophysiology is poorly understood, but immune alterations might be an important component. This study compare...

    Authors: Chinh Bkrong Nguyen, Lene Alsøe, Jessica M. Lindvall, Dag Sulheim, Even Fagermoen, Anette Winger, Mari Kaarbø, Hilde Nilsen and Vegard Bruun Wyller
    Citation: Journal of Translational Medicine 2017 15:102
  15. Hydrogen sulfide (H2S), previously only considered a toxic environmental air pollutant, is now increasingly recognized as an important signaling molecule able to modulate several cellular pathways in many human t...

    Authors: Francesca Benedetti, Sabrina Curreli, Selvi Krishnan, Sergio Davinelli, Fiorenza Cocchi, Giovanni Scapagnini, Robert C. Gallo and Davide Zella
    Citation: Journal of Translational Medicine 2017 15:100
  16. Malignant melanoma is an aggressive tumor sensitive for immunotherapy such as checkpoint blockade antibodies. Still, most patients with late stage disease do not respond, and the side effects can be severe. St...

    Authors: A. Schiza, J. Wenthe, S. Mangsbo, E. Eriksson, Anders Nilsson, T. H. Tötterman, A. Loskog and G. Ullenhag
    Citation: Journal of Translational Medicine 2017 15:79
  17. Liver fibrosis which mainly occurs upon chronic hepatitis virus infection potentially leads to portal hypertension, hepatic failure and hepatocellular carcinoma. However, the immune status of Th17 and Treg cel...

    Authors: Xiaoyan Li, Yujie Su, Xuefeng Hua, Chan Xie, Jing Liu, Yuehua Huang, Liang Zhou, Min Zhang, Xu Li and Zhiliang Gao
    Citation: Journal of Translational Medicine 2017 15:75
  18. Tuberculin skin test based on in vivo intradermal inoculation of purified protein derivative from Mycobacterium bovis (bPPD) is the diagnostic test for the control and surveillance of bovine tuberculosis (bTB).

    Authors: Sante Roperto, Mariaconcetta Varano, Valeria Russo, Roberta Lucà, Monica Cagiola, Marco Gaspari, Dora Maria Ceccarelli, Giovanni Cuda and Franco Roperto
    Citation: Journal of Translational Medicine 2017 15:68
  19. Lymphocyte expansion and true lymphocytosis are commonly observed in the everyday clinical practice. The meaning of such phenomenon is often poorly understood so that discrimination between benign and malignan...

    Authors: Andrea Picchianti Diamanti, Bruno Laganà, Maria Christina Cox, Emanuela Pilozzi, Rachele Amodeo, Maurizio Bove, Milica Markovic, Roberta Di Rosa, Simonetta Salemi, Maria Laura Sorgi, Maria Manuela Rosado and Raffaele D’Amelio
    Citation: Journal of Translational Medicine 2017 15:38
  20. Macrophages and neutrophils are key components involved in the regulation of numerous chronic inflammatory diseases, infectious disorders, and especially certain autoimmune disease. However, little is known re...

    Authors: Kely Campos Navegantes, Rafaelli de Souza Gomes, Priscilla Aparecida Tártari Pereira, Paula Giselle Czaikoski, Carolina Heitmann Mares Azevedo and Marta Chagas Monteiro
    Citation: Journal of Translational Medicine 2017 15:36
  21. Leflunomide is a low-molecular-weight compound that is widely used in the treatment of rheumatoid arthritis. Although leflunomide is thought to act through the inhibition of the de novo pyrimidine synthesis, t...

    Authors: Su-Jin Moon, Eun-Kyung Kim, Joo Yeon Jhun, Hee Jin Lee, Weon Sun Lee, Sang-Hi Park, Mi-La Cho and Jun-Ki Min
    Citation: Journal of Translational Medicine 2017 15:31
  22. Keratitis is a common cause of blindness. Current anti-inflammatory drugs used in keratitis have profound side effects. Small peptides derived from endogenous proteins potentially display both desired efficien...

    Authors: Shaopin Zhu, Xun Xu, Lili Wang, Li Su, Qing Gu, Fang Wei and Kun Liu
    Citation: Journal of Translational Medicine 2017 15:20
  23. Due to their self-renewal capacity, multi-lineage potential, and immunomodulatory properties, mesenchymal stromal cells (MSCs) are an attractive tool for different therapeutic strategies. Foreskin (FSK), consi...

    Authors: Hussein Fayyad-Kazan, Mohammad Fayyad-Kazan, Bassam Badran, Dominique Bron, Laurence Lagneaux and Mehdi Najar
    Citation: Journal of Translational Medicine 2017 15:10
  24. Prophylactic and therapeutic vaccines often depend upon a strong activation of the innate immune system to drive a potent adaptive immune response, often mediated by a strong adjuvant. For a number of adjuvant...

    Authors: Darin K. Edwards, Edith Jasny, Heesik Yoon, Nigel Horscroft, Brian Schanen, Tanya Geter, Mariola Fotin-Mleczek, Benjamin Petsch and Vaughan Wittman
    Citation: Journal of Translational Medicine 2017 15:1
  25. The mechanisms by which vaccinia virus (VACV) interacts with the innate immune components are complex and involve different mechanisms. iNOS-mediated NO production by myeloid cells is one of the central antivi...

    Authors: Mehmet Okyay Kilinc, Klaas Ehrig, Maysam Pessian, Boris R. Minev and Aladar A. Szalay
    Citation: Journal of Translational Medicine 2016 14:340
  26. An infection-immune association of periodontal disease with rheumatoid arthritis has been suggested. This study aimed to investigate the effect of pre-existing periodontitis on the development and the immune/i...

    Authors: Kaja Eriksson, Erik Lönnblom, Gregory Tour, Anna Kats, Piotr Mydel, Pierre Georgsson, Catharina Hultgren, Nastya Kharlamova, Ulrika Norin, Jörgen Jönsson, Anna Lundmark, Annelie Hellvard, Karin Lundberg, Leif Jansson, Rikard Holmdahl and Tülay Yucel-Lindberg
    Citation: Journal of Translational Medicine 2016 14:311
  27. Chemokines and chemokine receptors play important roles in autoimmune diseases; however, their role in immune thrombocytopenia (ITP) is unclear. High-dose dexamethasone (HD-DXM) may become a first-line therapy...

    Authors: Zongtang Liu, Meiying Wang, Shufen Zhou, Ji Ma, Yan Shi, Jun Peng, Ming Hou and Chengshan Guo
    Citation: Journal of Translational Medicine 2016 14:301
  28. Human adenovirus (HAdV) infections remain a significant cause of morbidity and mortality after hematopoietic stem cell transplantation (HSCT). Efficient antiviral T-cell responses are necessary to clear infect...

    Authors: Sabine Tischer, René Geyeregger, Julian Kwoczek, Albert Heim, Constanca Figueiredo, Rainer Blasczyk, Britta Maecker-Kolhoff and Britta Eiz-Vesper
    Citation: Journal of Translational Medicine 2016 14:286
  29. Asthma is prone to Th2-mediated chronic airway inflammation. Interleukin-27 (IL-27) is a member of the IL-12 family that promotes the differentiation of Th1 cells and inhibits Th2 cells. We use human/mouse CD4+ T...

    Authors: Xiaoqiong Su, Jue Pan, Fengxi Bai, Honglei Yuan, Nian Dong, Dandan Li, Xiangdong Wang and Zhihong Chen
    Citation: Journal of Translational Medicine 2016 14:283
  30. Cancer immunotherapy can be potentiated by conditioning regimens such as cyclophosphamide, which reduces the level of regulatory T cells (tregs). However, myeloid suppressive cells are still remaining. Accordi...

    Authors: Emma Eriksson, Jessica Wenthe, Sandra Irenaeus, Angelica Loskog and Gustav Ullenhag
    Citation: Journal of Translational Medicine 2016 14:282
  31. Cytokine-induced-killer (CIK) cells are a promising immunotherapeutic approach for impending relapse following hematopoietic stem cell transplantation (HSCT). However, there is a high risk for treatment failur...

    Authors: Melanie Bremm, Sabine Huenecke, Olga Zimmermann, Verena Pfirrmann, Andrea Quaiser, Halvard Bonig, Jan Soerensen, Thomas Klingebiel, Eva Rettinger, Peter Bader and Claudia Cappel
    Citation: Journal of Translational Medicine 2016 14:264
  32. The Vk*MYC transgenic and transplant mouse models of multiple myeloma (MM) are well established as a research tool for anti-myeloma drug discovery. However, little is known of the immune response in these mode...

    Authors: Rachel E. Cooke, Nicholas A. Gherardin, Simon J. Harrison, Hang Quach, Dale I. Godfrey, Miles Prince, Rachel Koldej and David S. Ritchie
    Citation: Journal of Translational Medicine 2016 14:259
  33. Tumour resistance to a wide range of drugs (multiple drug resistant, MDR) acquired after intensive chemotherapy is considered to be the main obstacle of the curative treatment of cancer patients. Recent work h...

    Authors: Elena P. Goncharova, Julia S. Ruzhenkova, Ivan S. Petrov, Sergey N. Shchelkunov and Marina A. Zenkova
    Citation: Journal of Translational Medicine 2016 14:241

    The Erratum to this article has been published in Journal of Translational Medicine 2016 14:280

  34. Only recently, the scientific community gained insights on the importance of the intestinal resident flora for the host’s health and disease. Gut microbiota in fact plays a crucial role in modulating innate an...

    Authors: Andrea Picchianti Diamanti, M. Manuela Rosado, Bruno Laganà and Raffaele D’Amelio
    Citation: Journal of Translational Medicine 2016 14:233
  35. Epstein-Barr virus and Cytomegalovirus reactivations frequently occur after allogeneic stem cell transplantation (SCT).

    Authors: Julia Drylewicz, Ingrid M. M. Schellens, Rogier Gaiser, Nening M. Nanlohy, Esther D. Quakkelaar, Henny Otten, Suzanne van Dorp, Ronald Jacobi, Leonie Ran, Sanne Spijkers, Dan Koning, Rob Schuurman, Ellen Meijer, Floortje L. Pietersma, Jurgen Kuball and Debbie van Baarle
    Citation: Journal of Translational Medicine 2016 14:230
  36. High-risk human papillomaviruses (HR-HPVs) types 16 and 18 are the main etiological agents of cervical cancer, with more than 550,000 new cases each year worldwide. HPVs are also associated with other ano-geni...

    Authors: Elena Illiano, Olivia Costantina Demurtas, Silvia Massa, Paola Di Bonito, Valerio Consalvi, Roberta Chiaraluce, Carlo Zanotto, Carlo De Giuli Morghen, Antonia Radaelli, Aldo Venuti and Rosella Franconi
    Citation: Journal of Translational Medicine 2016 14:224
  37. Immunotherapy based on the adoptive transfer of gene modified T cells is an emerging approach for the induction of tumor-specific immune responses. Memory stem T cells, due to their enhanced antitumor and self...

    Authors: C. Alvarez-Fernández, L. Escribà-Garcia, S. Vidal, J. Sierra and J. Briones
    Citation: Journal of Translational Medicine 2016 14:214
  38. T helper (Th) 17 cells are a subset of T helper cells that express interleukin (IL)-17 and initiate the inflammatory response in autoimmune diseases. Regulatory T cells (Tregs) are a subpopulation of T cells t...

    Authors: Min-Jung Park, Seung Hoon Lee, Sung-Hee Lee, Eun-Kyung Kim, Eun Jung Lee, Young-Mee Moon and Mi- La Cho
    Citation: Journal of Translational Medicine 2016 14:206
  39. Foxp3 is a key regulator of the development and function of regulatory T cells (Tregs), and its expression is thought to be T cell-restricted. We found that B cells in mice can express Foxp3 and B cells expres...

    Authors: Mi Kyung Park, Young Ok Jung, Seon-Yeong Lee, Seung Hoon Lee, Yu Jung Heo, Eun Kyung Kim, Hye Jwa Oh, Young Mee Moon, Hye-Jin Son, Min Jung Park, Sung Hwan Park, Ho Youn Kim, Mi La Cho and Jun Ki Min
    Citation: Journal of Translational Medicine 2016 14:191

    The Erratum to this article has been published in Journal of Translational Medicine 2016 14:221

  40. Spondyloarthritis (SpA) usually manifests as arthritis of the axial and peripheral joints but can also result in extra-articular manifestations such as inflammatory bowel disease. Proinflammatory cytokine inte...

    Authors: Hong-Ki Min, Jae-Kyung Kim, Seon-Yeong Lee, Eun-Kyung Kim, Seung Hoon Lee, Jennifer Lee, Seung-Ki Kwok, Mi-La Cho and Sung-Hwan Park
    Citation: Journal of Translational Medicine 2016 14:190
  41. TNF weakly inducer of apoptosis (TWEAK) is member of the TNF ligand superfamily. Various data support that TWEAK produced by synovial macrophages may contribute to synovitis observed in psoriatic arthritis (P...

    Authors: Sandrine Guis, Philippe Berbis, Delphine Stephan, Daniel Bertin, Florent Amatore, Nathalie Balandraud, Nathalie Lesavre and Sophie Desplat-Jégo
    Citation: Journal of Translational Medicine 2016 14:185
  42. Exosomes are nano-sized extracellular vesicles participating in cell-to-cell communication both in health and disease. However, the knowledge about the functions and molecular composition of exosomes in the up...

    Authors: Cecilia Lässer, Serena E. O’Neil, Ganesh V. Shelke, Carina Sihlbom, Sara F. Hansson, Yong Song Gho, Bo Lundbäck and Jan Lötvall
    Citation: Journal of Translational Medicine 2016 14:181
  43. Tuberculosis (TB) remains a major public health concern worldwide. Previous studies have demonstrated that IL-17 plays an important role in initial immune response and is involved in both immune-mediated prote...

    Authors: Lichen Xu, Guangying Cui, Hongyu Jia, Yunan Zhu, Yulong Ding, Jianing Chen, Chong Lu, Ping Ye, Hainv Gao, Lanjuan Li, Weihang Ma, Jianxin Lyu and Hongyan Diao
    Citation: Journal of Translational Medicine 2016 14:179
  44. The risk for developing cardiovascular disease is greater in patients with rheumatoid arthritis (RA) than in the general population. While patients with RA also have dyslipidemia, the impact of dyslipidemia on...

    Authors: Amy M. Archer, Rana Saber, Shawn Rose, Alexander Shaffer, Alexander V. Misharin, FuNien Tsai, G. Kenneth Haines III, Salina Dominguez, Mesut Eren, Douglas E. Vaughan, Carla M. Cuda and Harris Perlman
    Citation: Journal of Translational Medicine 2016 14:170
  45. Organizing pneumonia is a reaction pattern and an inflammatory response to acute lung injuries, and is characterized by intraluminal plugs of granulation tissue in distal airspaces. In contrast to other fibrot...

    Authors: Nicole Izykowski, Mark Kuehnel, Kais Hussein, Kristin Mitschke, Michael Gunn, Sabina Janciauskiene, Axel Haverich, Gregor Warnecke, Florian Laenger, Ulrich Maus and Danny Jonigk
    Citation: Journal of Translational Medicine 2016 14:169
  46. Our previous results showed that intrasynovial Rifamycin SV caused the lysis of synoviocites and freed the autoantigens which in turn stimulated the immunoregulatory rather than autoreactive T cell response in...

    Authors: Innocenzo Caruso, Salvatore Santandrea, Mariarita Gismondo, Alessandra Lombardi, Franco Montrone, Enzo Massimo Caruso and Piercarlo Sarzi Puttini
    Citation: Journal of Translational Medicine 2016 14:162
  47. NLRP3 inflammasome has been implicated in the pathogenesis of systemic lupus erythematosus (SLE). The activation of NLRP3 inflammasome results in the production of IL-1β and the subsequent inflammation. Anti-d...

    Authors: Hui Zhang, Rong Fu, Chaohuan Guo, Yuefang Huang, Hongyue Wang, Shuang Wang, Jijun Zhao and Niansheng Yang
    Citation: Journal of Translational Medicine 2016 14:156
  48. Noroviruses (NoVs) are a major cause of childhood gastroenteritis and foodborne diseases worldwide. Lack of appropriate animal models or cell-based culture systems makes the development and evaluation of NoV-s...

    Authors: Vivek Verma, Wenzhi Tan, Sao Puth, Kyoung-Oh Cho, Shee Eun Lee and Joon Haeng Rhee
    Citation: Journal of Translational Medicine 2016 14:135
  49. Dendritic cells (DCs) rendered suppressive by treatment with mitomycin C and loaded with the autoantigen myelin basic protein demonstrated earlier their ability to prevent experimental autoimmune encephalomyel...

    Authors: Christian Kleist, Elisabeth Mohr, Sadanand Gaikwad, Laura Dittmar, Stefanie Kuerten, Michael Platten, Walter Mier, Michael Schmitt, Gerhard Opelz and Peter Terness
    Citation: Journal of Translational Medicine 2016 14:99
  50. Allogeneic hematopoietic stem cell transplantation (allo-HSCT) has been established as an effective treatment for patients with hematological malignancies. Disease relapse remains a major cause of transplant f...

    Authors: X.-Y. Qin, Y. Wang, G.-X. Li, Y.-Z. Qin, F.-R. Wang, L.-P. Xu, H. Chen, W. Han, J.-Z. Wang, X.-H. Zhang, Y.-J. Chang, K.-Y. Liu, Z.-F. Jiang and X.-J. Huang
    Citation: Journal of Translational Medicine 2016 14:100

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