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Disease Biomarkers

Section edited by Xiangdong Wang and Hao Fang

The Disease Biomarkers section aims to bridge the identification and validation of discovered gene or protein-based, network or dynamic network biomarkers with human diseases, patient phenotypes, or clinical applications, and accelerate the development of human disease-specific biomarkers for the early diagnosis, monitoring, evaluation, and prediction of diseases. Conditions including cancers, cardiovascular and metabolic diseases will be the focus of study. This section will promote the innovation and development of disease-specific biomarkers by integrating multidisciplinary aspects of science.

Studies considered for publication include those regarding the development of advanced biotechnologies for biomarker discovery and development, identifying biomarkers associated with the early detection of diseases, monitoring of disease severity and duration as well as patient responses to therapies, prediction of patient outcomes and the evaluation, regulation and ethics of disease biomarkers.

Featured articles

Microfluidic devices for neutrophil chemotaxis studies

Review | Wenjie Zhao et al

Plasma proteomic analysis of autoimmune hepatitis in an improved AIH mouse model

Research | Han Wang et al

Multi-omic serum biomarkers for prognosis of disease progression in prostate cancer

Research | Michael A. Kiebish et al

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  1. Aberrant glycosylation has been recognized as a hallmark of cancer and N-glycosylation is one of the main types of glycosylation in eukaryotes. Although N-glycoproteomics has made contributions to the discover...

    Authors: Yingzhen Gao, Liuyi Shen, Tianyue Dong, Xin Yang, Heyang Cui, Yanlin Guo, Yanchun Ma, Pengzhou Kong, Xiaolong Cheng, Ling Zhang and Yongping Cui
    Citation: Journal of Translational Medicine 2022 20:285
  2. Senescent cells have been identified in the aging prostate, and the senescence-associated secretory phenotype might be linked to prostate cancer (PCa). Thus, we established a cellular senescence-related gene p...

    Authors: Dechao Feng, Dengxiong Li, Xu Shi, Qiao Xiong, Facai Zhang, Qiang Wei and Lu Yang
    Citation: Journal of Translational Medicine 2022 20:252
  3. Extracellular vesicle (EV)-microRNAs (miRNAs) are potential biomarkers for various renal diseases. This study attempted to identify the circulating EV-miRNA signature not only for discriminating idiopathic mem...

    Authors: In O. Sun, Yun-Ui Bae, Haekyung Lee, Hyoungnae Kim, Jin Seok Jeon, Hyunjin Noh, Jong-Soo Choi, Kyung-Oh Doh and Soon Hyo Kwon
    Citation: Journal of Translational Medicine 2022 20:224
  4. Platinum-based chemotherapies are currently the first-line treatment of non-small cell lung cancer. This study will improve our understanding of the causes of resistance to cisplatin, especially in lung adeno...

    Authors: Qihai Sui, Zhencong Chen, Zhengyang Hu, Yiwei Huang, Jiaqi Liang, Guoshu Bi, Yunyi Bian, Mengnan Zhao, Cheng Zhan, Zongwu Lin, Qun Wang and Lijie Tan
    Citation: Journal of Translational Medicine 2022 20:171
  5. The kallikrein-kinin system is assumed to have a multifunctional role in health and disease, but its in vivo role in humans currently remains unclear owing to the divergence of plasma kinin level data publishe...

    Authors: Tanja Gangnus, Anke Bartel and Bjoern B. Burckhardt
    Citation: Journal of Translational Medicine 2022 20:146
  6. To identify the critical genes in the onset and progression of Immunoglobulin A nephropathy (IgAN) and to explore its immune cell infiltration feature.

    Authors: Jie Xu, Xiahong Shen, Xing Wei, Jie Ding, Jiaojiao Yuan, Zhen Weng and Yang He
    Citation: Journal of Translational Medicine 2022 20:145
  7. The effect of the cytochrome P450 oxidoreductase (POR) rs10954732 (G > A) polymorphism on hepatocellular carcinoma (HCC) susceptibility is unknown. Here we found that A allele carriers showed a 69% decrease in su...

    Authors: Yan Fang, Hongming Yang, Guiming Hu, Jiakun Lu, Jun Zhou, Na Gao, Yuhan Gu, Cunzhen Zhang, Jinhuan Qiu, Yuanyuan Guo, Yunfei Zhang, Qiang Wen and Hailing Qiao
    Citation: Journal of Translational Medicine 2022 20:88
  8. Emerging evidences have indicated that the aberrant liquid–liquid phase separation (LLPS) leads to the dysfunction of biomolecular condensates, thereby contributing to the tumorigenesis and progression. Nevert...

    Authors: Jianglin Zheng, Zhipeng Wu, Yue Qiu, Xuan Wang and Xiaobing Jiang
    Citation: Journal of Translational Medicine 2022 20:55
  9. Cumulative evidence indicates that the abnormal regulation of the NEDD4 family of E3-ubiquitin ligases participates in the tumorigenesis and development of cancer. However, their role in lung adenocarcinoma (L...

    Authors: Guoyin Li, Zewen Song, Changjing Wu, XiaoYan Li, Liping Zhao, Binghua Tong, Zhenni Guo, Meiqing Sun, Jin Zhao, Huina Zhang, Lintao Jia, Shengqing Li and Lei Wang
    Citation: Journal of Translational Medicine 2022 20:47
  10. Morphea is an autoimmune, sclerosing skin disorder. Despite the recent emphasis on immune dysregulation in morphea, the role of autoantibodies in morphea pathogenesis or utility as biomarkers are poorly defined.

    Authors: Jane L. Zhu, Ricardo T. Paniagua, Henry W. Chen, Stephanie Florez-Pollack, Elaine Kunzler, Noelle Teske, Yevgeniya Byekova Rainwater, Quan-Zhen Li, Gregory A. Hosler, Wenhao Li, Denise M. O. Ramirez, Nancy L. Monson and Heidi T. Jacobe
    Citation: Journal of Translational Medicine 2022 20:41
  11. Ovarian cancer (OC), an important cause of cancer-related death in women worldwide, is one of the most malignant cancers and is characterized by a poor prognosis. RNA-binding proteins (RBPs), a class of endoge...

    Authors: Jiangchun Wu, Yong Wu, Qinhao Guo, Simin Wang and Xiaohua Wu
    Citation: Journal of Translational Medicine 2022 20:37
  12. Cervical cancer is the most fatal gynecological carcinoma in the world. It is urgent to explore novel prognostic biomarkers and intervention targets for cervical cancer.

    Authors: Huiqiong Bao, Xiaobin Li, Zhixing Cao, Zhihong Huang, Li Chen, Mingbing Wang, Jiali Hu, Wenting Li, Hongwei Sun, Xue Jiang, Ping Mei, Huawen Li, Ligong Lu and Meixiao Zhan
    Citation: Journal of Translational Medicine 2022 20:18
  13. Gestational diabetes mellitus (GDM) seriously affects the health of mothers and babies, and there are still no effective early diagnostic markers. Therefore, it is necessary to find diagnostic biomarkers for s...

    Authors: Bao Jiang, Junfeng Zhang, Xiubin Sun, Chunyan Yang, Guanghui Cheng, Mengru Xu, Siyuan Li and Lina Wang
    Citation: Journal of Translational Medicine 2022 20:5
  14. N6-methyladenosine (m6A), the most abundant and reversible modification of mRNAs in eukaryotes, plays pivotal role in breast cancer (BC) tumorigenesis and progression. Circular RNAs (circRNAs) can act as tumor...

    Authors: Wenchang Lv, Yufang Tan, Mingchen Xiong, Chongru Zhao, Yichen Wang, Min Wu, Yiping Wu and Qi Zhang
    Citation: Journal of Translational Medicine 2021 19:527
  15. Reduced cardiovascular risk in premenopausal women has been the focus of research in recent decades. Previous hypothesis-driven experiments have highlighted the role of sex hormones on distinct inflammatory re...

    Authors: Bálint András Barta, Mihály Ruppert, Klemens Erwin Fröhlich, Miguel Cosenza-Contreras, Attila Oláh, Alex Ali Sayour, Krisztián Kovács, Gellért Balázs Karvaly, Martin Biniossek, Béla Merkely, Oliver Schilling and Tamás Radovits
    Citation: Journal of Translational Medicine 2021 19:507
  16. Diagnosing seronegative rheumatoid arthritis (RA) can be challenging due to complex diagnostic criteria. We sought to discover diagnostic biomarkers for seronegative RA cases by studying metabolomic and lipido...

    Authors: Hemi Luan, Wanjian Gu, Hua Li, Zi Wang, Lu Lu, Mengying Ke, Jiawei Lu, Wenjun Chen, Zhangzhang Lan, Yanlin Xiao, Jinyue Xu, Yi Zhang, Zongwei Cai, Shijia Liu and Wenyong Zhang
    Citation: Journal of Translational Medicine 2021 19:500
  17. Intestinal ischemia/reperfusion (I/R) injury commonly occurs during perioperative periods, resulting in high morbidity and mortality on a global scale. Dexmedetomidine (Dex) is a selective α2-agonist that is f...

    Authors: Qin Zhang, Xiao-Ming Liu, Qian Hu, Zheng-Ren Liu, Zhi-Yi Liu, Huai-Gen Zhang, Yuan-Lu Huang, Qiu-Hong Chen, Wen-Xiang Wang and Xue-Kang Zhang
    Citation: Journal of Translational Medicine 2021 19:463
  18. Although an association between the cytochrome P4502D6 (CYP2D6) *10 (100C>T) polymorphism and hepatocellular carcinoma (HCC) is known, the mechanism remains unclear. Here we aimed to explore mechanisms of CYP2...

    Authors: Guiming Hu, Fei Gao, Guanzhe Wang, Yan Fang, Yuanyuan Guo, Jun Zhou, Yuhan Gu, Cunzhen Zhang, Na Gao, Qiang Wen and Hailing Qiao
    Citation: Journal of Translational Medicine 2021 19:359
  19. A novel and improved methodology is still required for the diagnosis of diabetic kidney disease (DKD). The aim of the present study was to identify novel biomarkers using extracellular vesicle (EV)-derived mRN...

    Authors: Yiying Tao, Xing Wei, Yue Yue, Jiaxin Wang, Jianzhong Li, Lei Shen, Guoyuan Lu, Yang He, Shidi Zhao, Fan Zhao, Zhen Weng, Xiahong Shen and Ling Zhou
    Citation: Journal of Translational Medicine 2021 19:326
  20. Epithelial-mesenchymal transition (EMT) of mesothelial cells is a key step in the peritoneal fibrosis (PF). Recent evidence indicates that signal transducer and activator of transcription 3 (STAT3) might media...

    Authors: Xiaoxiao Yang, Manchen Bao, Yi Fang, Xiaofang Yu, Jun Ji and Xiaoqiang Ding
    Citation: Journal of Translational Medicine 2021 19:283
  21. Window of implantation (WOI) displacement is one of the endometrial origins of embryo implantation failure, especially repeated implantation failure (RIF). An accurate prediction tool for endometrial receptivi...

    Authors: Aihua He, Yangyun Zou, Cheng Wan, Jing Zhao, Qiong Zhang, Zhongyuan Yao, Fen Tian, Hong Wu, Xi Huang, Jing Fu, Chunxu Hu, Yue Sun, Lan Xiao, Tianli Yang, Zhaojuan Hou, Xin Dong…
    Citation: Journal of Translational Medicine 2021 19:176
  22. Cigarette smoking constitutes a major lifestyle risk factor for osteoporosis and hip fracture. It is reported to impair the outcome of many clinical procedures, such as wound infection treatment and fracture h...

    Authors: Yi Lu, Yuanpu Peter Di, Ming Chang, Xin Huang, Qiuyan Chen, Ni Hong, Beth A. Kahkonen, Marissa E. Di, Chunyan Yu, Evan T. Keller and Jian Zhang
    Citation: Journal of Translational Medicine 2021 19:163
  23. Due to insufficient accuracy, urine-based assays currently have a limited role in the management of patients with bladder cancer. The identification of multiplex molecular signatures associated with disease ha...

    Authors: Yosuke Hirasawa, Ian Pagano, Runpu Chen, Yijun Sun, Yunfeng Dai, Amit Gupta, Sergei Tikhonenkov, Steve Goodison, Charles J. Rosser and Hideki Furuya
    Citation: Journal of Translational Medicine 2021 19:141
  24. As the fourth leading cause of cancer-related death in the world, the therapeutic effect and 5-year overall survival of hepatocellular carcinoma (HCC) are not optimistic. Previous researches indicated that the...

    Authors: Mingxing Xu, Jianliang Xu, Dun Zhu, Rishun Su, Baoding Zhuang, Ruiyun Xu, Lingli Li, Shuxian Chen and Yunbiao Ling
    Citation: Journal of Translational Medicine 2021 19:126
  25. Chronic obstructive pulmonary disease (COPD) is a progressive, life-threatening lung disease with increasing prevalence and incidence worldwide. Increasing evidence suggests that lung microbiomes might play a ...

    Authors: Chia-Yu Yang, Shiao-Wen Li, Chia-Yin Chin, Chia-Wei Hsu, Chi-Ching Lee, Yuan-Ming Yeh and Kuo-An Wu
    Citation: Journal of Translational Medicine 2021 19:121
  26. Acute kidney injury (AKI), with a high morbidity and mortality, is recognized as a risk factor for chronic kidney disease (CKD). AKI-CKD transition has been regarded as one of the most pressing unmet needs in ...

    Authors: Jinxiu Hu, Jiao Qiao, Qun Yu, Bing Liu, Junhui Zhen, Yue Liu, Qiqi Ma, Yanmei Li, Qianhui Wang, Cheng Wang and Zhimei Lv
    Citation: Journal of Translational Medicine 2021 19:69
  27. Thoracic aortic aneurysm (TAA) can be life-threatening due to the progressive weakening and dilatation of the aortic wall. Once the aortic wall has ruptured, no effective pharmaceutical therapies are available...

    Authors: Chuxiang Lei, Dan Yang, Wenlin Chen, Haoxuan Kan, Fang Xu, Hui Zhang, Wei Wang, Lei Ji and Yuehong Zheng
    Citation: Journal of Translational Medicine 2021 19:49
  28. Extensive extracellular matrix (ECM) remodeling is a hallmark of metastatic pancreatic ductal adenocarcinoma (mPDA). We investigated fragments of collagen types III (C3M, PRO-C3), VI (PRO-C6), and VIII (C8-C),...

    Authors: Song Wang, Cecilie L. Bager, Morten A. Karsdal, Dimitrios Chondros, Darin Taverna and Nicholas Willumsen
    Citation: Journal of Translational Medicine 2021 19:39
  29. Major depressive disorder (MDD), common mental disorder, lacks objective diagnostic and prognosis biomarkers. The objective of this study was to perform proteomic analysis to identify proteins with changed exp...

    Authors: Hye In Woo, Jisook Park, Shinn-Won Lim, Doh Kwan Kim and Soo-Youn Lee
    Citation: Journal of Translational Medicine 2021 19:34
  30. Late-onset asthma (LOA) is beginning to account for an increasing proportion of asthma patients, which is often underdiagnosed in the elderly. Studies on the possible relations between aging-related genes and ...

    Authors: Lin Yuan, Leyuan Wang, Xizi Du, Ling Qin, Ming Yang, Kai Zhou, Mengping Wu, Yu Yang, Zhiyuan Zheng, Yang Xiang, Xiangping Qu, Huijun Liu, Xiaoqun Qin and Chi Liu
    Citation: Journal of Translational Medicine 2020 18:467

    The Correction to this article has been published in Journal of Translational Medicine 2021 19:107

  31. In the present study the blood expression level of inflammatory response and autoimmunity associated long non-coding RNAs (lncRNAs) were compared in patients with different chronic respiratory diseases and inv...

    Authors: Zsófia Gál, András Gézsi, Ágnes F. Semsei, Adrienne Nagy, Monika Sultész, Zsuzsanna Csoma, Lilla Tamási, Gabriella Gálffy and Csaba Szalai
    Citation: Journal of Translational Medicine 2020 18:422
  32. Heavy tobacco smoking, a hallmark feature of lung cancer, is drastically predominant in Middle Eastern populations. The precise links between nicotine dependence and the functional contribution of the oral mic...

    Authors: Mohammad Tahseen Al Bataineh, Nihar Ranjan Dash, Mohammed Elkhazendar, Dua’a Mohammad Hasan Alnusairat, Islam Mohammad Ismail Darwish, Mohamed Saleh Al-Hajjaj and Qutayba Hamid
    Citation: Journal of Translational Medicine 2020 18:421
  33. Intracranial aneurysms (IAs) are dangerous because of their potential to rupture. We previously found significant RNA expression differences in circulating neutrophils between patients with and without unruptu...

    Authors: Kerry E. Poppenberg, Vincent M. Tutino, Lu Li, Muhammad Waqas, Armond June, Lee Chaves, Kaiyu Jiang, James N. Jarvis, Yijun Sun, Kenneth V. Snyder, Elad I. Levy, Adnan H. Siddiqui, John Kolega and Hui Meng
    Citation: Journal of Translational Medicine 2020 18:392
  34. Many contradictory conclusions pertaining to the telomere length in peripheral leukocyte chromosomes as a potential biomarker for ischemic stroke (IS) risk have been reported by the various observational studi...

    Authors: Weijie Cao, Deqiang Zheng, Jie Zhang, Anxin Wang, Di Liu, Jinxia Zhang, Manjot Singh, Isinta Elijah Maranga, Mingyang Cao, Lijuan Wu, Manshu Song, Wei Wang and Youxin Wang
    Citation: Journal of Translational Medicine 2020 18:385
  35. To introduce the Hemorrhage Intensive Severity and Survivability (HISS) score, based on the fusion of multi-biomarker data; glucose, lactate, pH, potassium, and oxygen tension, to serve as a patient-specific a...

    Authors: Ankita Bhat, Daria Podstawczyk, Brandon K. Walther, John R. Aggas, David Machado-Aranda, Kevin R. Ward and Anthony Guiseppi-Elie
    Citation: Journal of Translational Medicine 2020 18:348
  36. Microtia is a congenital anomaly of ear that ranges in severity from mild structural abnormalities to complete absence of the outer ears. Concha-type microtia is considered to be a mild form. The H6 family hom...

    Authors: Nuo Si, Xiaolu Meng, Xiaosheng Lu, Zhe Liu, Zhan Qi, Lianqing Wang, Chuan Li, Meirong Yang, Ye Zhang, Changchen Wang, Peipei Guo, Lingdong Zhu, Lei Liu, Zhengyong Li, Zhenyu Zhang, Zhen Cai…
    Citation: Journal of Translational Medicine 2020 18:244
  37. The etiology of congenital scoliosis (CS) is complex and uncertain. Abnormal DNA methylation affects the growth and development of spinal development. In this study, we investigated the role of DNA methylation...

    Authors: Yuantao Wu, Hongqi Zhang, Mingxing Tang, Chaofeng Guo, Ang Deng, Jiong Li, Yunjia Wang, Lige Xiao and Guanteng Yang
    Citation: Journal of Translational Medicine 2020 18:210
  38. Primary glomerulonephritis (GN) is the leading cause of chronic kidney disease (CKD) and frequently progresses into end stage renal diseases (ESRDs). Shorter leukocyte telomere length (LTL) has been implicated...

    Authors: Qing Sun, Junli Liu, Guanghui Cheng, Mingkai Dai, Jiaxi Liu, Zhenqiang Qi, Jingjie Zhao, Wei Li, Feng Kong, Gang Liu, Magnus Björkholm and Dawei Xu
    Citation: Journal of Translational Medicine 2020 18:184
  39. Recently, the role of IL-19, IL-20 and IL-24 has been reported in renal disorders. However, still little is known about their biological role.

    Authors: Domonkos Pap, Apor Veres-Székely, Beáta Szebeni, Réka Rokonay, Anna Ónody, Rita Lippai, István Márton Takács, András Tislér, Magdolna Kardos, Franz Oswald, Andrea Fekete, Attila J. Szabó and Ádám Vannay
    Citation: Journal of Translational Medicine 2020 18:172
  40. Neutrophil chemotaxis plays a vital role in human immune system. Compared with traditional cell migration assays, the emergence of microfluidics provides a new research platform of cell chemotaxis study due to...

    Authors: Wenjie Zhao, Haiping Zhao, Mingxiao Li and Chengjun Huang
    Citation: Journal of Translational Medicine 2020 18:168
  41. Nonalcoholic fatty liver disease (NAFLD) is the main cause for hepatocellular carcinoma (HCC). This study was intended to identify the function of long non-coding RNA (lncRNA) lncARSR in NAFLD and its role in ...

    Authors: Yuan Chi, Zheng Gong, He Xin, Ziwen Wang and Zhaoyu Liu
    Citation: Journal of Translational Medicine 2020 18:126

    The Correction to this article has been published in Journal of Translational Medicine 2021 19:438

  42. Rats with hyperandrogen-induced polycystic ovary syndrome (PCOS) have been shown to develop ovarian oxidative stress (OS) and fibrosis. The Sirt1 agonist, resveratrol, can reduce OS through inhibiting p66Shc i...

    Authors: Daojuan Wang, Tingyu Wang, Rong Wang, Xinlin Zhang, Lei Wang, Zou Xiang, Lingjia Zhuang, Shanmei Shen, Hongwei Wang, Qian Gao and Yong Wang
    Citation: Journal of Translational Medicine 2020 18:84
  43. Clear cell renal cell carcinoma (ccRCC) is one of the most aggressive urological malignancies. MicroRNAs (miRNAs) are post-transcriptional gene regulators in tumor pathophysiology. As miRNAs exert cooperative ...

    Authors: Jiajia Chen, Yuqing Zhong and Liangzhi Li
    Citation: Journal of Translational Medicine 2020 18:69
  44. Circulating tumor cells (CTCs) has been demonstrated as a promising liquid biopsy marker for breast cancer (BC). However, the intra-patient heterogeneity of CTCs remains a challenge to clinical application. We...

    Authors: Jing Chen, Changsheng Ye, Jianyu Dong, Shunwang Cao, Yanwei Hu, Bo Situ, Xiaoxue Xi, Sihua Qin, Jiasen Xu, Zhen Cai, Lei Zheng and Qian Wang
    Citation: Journal of Translational Medicine 2020 18:59
  45. Predicting the clinical course of prostate cancer is challenging due to the wide biological spectrum of the disease. The objective of our study was to identify prostate cancer prognostic markers in patients ‘s...

    Authors: Michael A. Kiebish, Jennifer Cullen, Prachi Mishra, Amina Ali, Eric Milliman, Leonardo O. Rodrigues, Emily Y. Chen, Vladimir Tolstikov, Lixia Zhang, Kiki Panagopoulos, Punit Shah, Yongmei Chen, Gyorgy Petrovics, Inger L. Rosner, Isabell A. Sesterhenn, David G. McLeod…
    Citation: Journal of Translational Medicine 2020 18:10
  46. The timely diagnosis of bacterial meningitis is of utmost importance due to the need to institute antibiotic treatment as early as possible. Moreover, the differentiation from other causes of meningitis/enceph...

    Authors: Leonardo Silva de Araujo, Kevin Pessler, Kurt-Wolfram Sühs, Natalia Novoselova, Frank Klawonn, Maike Kuhn, Volkhard Kaever, Kirsten Müller-Vahl, Corinna Trebst, Thomas Skripuletz, Martin Stangel and Frank Pessler
    Citation: Journal of Translational Medicine 2020 18:9
  47. The prevalence of autoimmune hepatitis (AIH) is increasing, and its early clinical diagnosis is difficult. The pathogenesis of AIH remains unclear, and AIH-related studies are largely limited because of lack o...

    Authors: Han Wang, Wei Yan, Zuohua Feng, Yuan Gao, Liu Zhang, Xinxia Feng and Dean Tian
    Citation: Journal of Translational Medicine 2020 18:3

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