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Disease Biomarkers

Section edited by Xiangdong Wang and Hao Fang

The Disease Biomarkers section aims to bridge the identification and validation of discovered gene or protein-based, network or dynamic network biomarkers with human diseases, patient phenotypes, or clinical applications, and accelerate the development of human disease-specific biomarkers for the early diagnosis, monitoring, evaluation, and prediction of diseases. Conditions including cancers, cardiovascular and metabolic diseases will be the focus of study. This section will promote the innovation and development of disease-specific biomarkers by integrating multidisciplinary aspects of science.

Studies considered for publication include those regarding the development of advanced biotechnologies for biomarker discovery and development, identifying biomarkers associated with the early detection of diseases, monitoring of disease severity and duration as well as patient responses to therapies, prediction of patient outcomes and the evaluation, regulation and ethics of disease biomarkers.

Featured articles

Microfluidic devices for neutrophil chemotaxis studies

Review | Wenjie Zhao et al

Plasma proteomic analysis of autoimmune hepatitis in an improved AIH mouse model

Research | Han Wang et al

Multi-omic serum biomarkers for prognosis of disease progression in prostate cancer

Research | Michael A. Kiebish et al

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  1. ATM and ATR are two critical factors to regulate DNA damage response (DDR), and their mutations were frequently observed in different types of cancer, including non-small cell lung cancer (NSCLC). Given that t...

    Authors: Wei Wei, Fangfang Shi, Yang Xu, Yang Jiao, Ying Zhang, Qiuxiang Ou, Xue Wu, Lingyi Yang and Jinhuo Lai
    Citation: Journal of Translational Medicine 2023 21:874
    Content type: Research Published on:

  2. The Neutrophil-to-lymphocyte ratio (NLR) is a marker of poor prognosis in hospitalized older patients with different diseases, but there is still no consensus on the optimal cut-off value to identify older pat...

    Authors: Mirko Di Rosa, Jacopo Sabbatinelli, Luca Soraci, Andrea Corsonello, Anna Rita Bonfigli, Antonio Cherubini, Riccardo Sarzani, Roberto Antonicelli, Giuseppe Pelliccioni, Roberta Galeazzi, Francesca Marchegiani, Salvatore Iuorio, Daniele Colombo, Maurizio Burattini, Fabrizia Lattanzio and Fabiola Olivieri
    Citation: Journal of Translational Medicine 2023 21:835
    Content type: Research Published on:

  3. Cancer is a malignant tumor that seriously threatens human life and health. At present, the main treatment methods include surgical resection, chemotherapy, radiotherapy, and immunotherapy. However, the mechan...

    Authors: Shangming Dai, Fengjiao Li, Shuoguo Xu, Jinda Hu and Lichen Gao
    Citation: Journal of Translational Medicine 2023 21:769
    Content type: Review Published on:

  4. Acute myocardial infarction (AMI) has two clinical characteristics: high missed diagnosis and dysfunction of leukocytes. Transcriptional RNA on leukocytes is closely related to the course evolution of AMI pati...

    Authors: Lin Zhang, Yue Liu, Kaiyue Wang, Xiangqin Ou, Jiashun Zhou, Houliang Zhang, Min Huang, Zhenfang Du and Sheng Qiang
    Citation: Journal of Translational Medicine 2023 21:761
    Content type: Research Published on:

  5. There is evidence of pre-established vulnerability in individuals that increases the risk of their progression to severe disease or death, although the mechanisms causing this are still not fully understood. P...

    Authors: Felix Keller, Joachim Beige, Justyna Siwy, Alexandre Mebazaa, Dewei An, Harald Mischak, Joost P. Schanstra, Marika Mokou, Paul Perco, Jan A. Staessen, Antonia Vlahou and Agnieszka Latosinska
    Citation: Journal of Translational Medicine 2023 21:663
    Content type: Research Published on:

  6. The activation of CD8+ T cells and their trafficking to the skin through JAK-STAT signaling play a central role in the development of vitiligo. Thus, targeting this key disease pathway with innovative drugs is an...

    Authors: Yuqian Chang, Pan Kang, Tingting Cui, Weinan Guo, Weigang Zhang, Pengran Du, Xiuli Yi, Sen Guo, Tianwen Gao, Chunying Li and Shuli Li
    Citation: Journal of Translational Medicine 2023 21:434
    Content type: Research Published on:

  7. Immunocheckpoint inhibitors (ICIs) have been widely used in the clinical treatment of lung cancer. Although clinical studies and trials have shown that patients can benefit significantly after PD-1/PD-L1 block...

    Authors: Tongyuan Qu, Wenshuai Zhang, Chenhui Yan, Danyang Ren, Yalei Wang, Yuhong Guo, Qianru Guo, Jinpeng Wang, Liren Liu, Lei Han, Lingmei Li, Qiujuan Huang, Lu Cao, Zhaoxiang Ye, Bin Zhang, Qiang Zhao…
    Citation: Journal of Translational Medicine 2023 21:341
    Content type: Research Published on:

  8. Disruption of N6 methyl adenosine (m6A) modulation hampers gene expression and cellular functions, leading to various illnesses. However, the role of m6A modification in osteoarthritis (OA) synovitis remains u...

    Authors: Yuheng Lu, Hongbo Zhang, Haoyan Pan, Zhicheng Zhang, Hua Zeng, Haoyu Xie, Jianbin Yin, Wen Tang, Rengui Lin, Chun Zeng and Daozhang Cai
    Citation: Journal of Translational Medicine 2023 21:339
    Content type: Research Published on:

  9. Eukaryotic cells are segmented into multiple compartments or organelles within the cell that regulate distinct chemical and biological processes. Membrane-less organelles are membrane-less microscopic cellular...

    Authors: Qingqing Xie, Jiejuan Cheng, Wuxuan Mei, Dexing Yang, Pengfei Zhang and Changchun Zeng
    Citation: Journal of Translational Medicine 2023 21:237
    Content type: Review Published on:

  10. Cancer is a worldwide pandemic. The burden it imposes grows steadily on a global scale causing emotional, physical, and financial strains on individuals, families, and health care systems. Despite being the se...

    Authors: Siobhan Connal, James M. Cameron, Alexandra Sala, Paul M. Brennan, David S. Palmer, Joshua D. Palmer, Haley Perlow and Matthew J. Baker
    Citation: Journal of Translational Medicine 2023 21:118
    Content type: Review Published on:

  11. Cerebral small vessel disease (CSVD) is a systemic disease, affecting not only the brain, but also eyes and other organs. The total CSVD score is a tool for comprehensive evaluation of brain lesions in patient...

    Authors: Jia-lin Wang, Xue-ru Cheng, Zhao-yang Meng and Yan-ling Wang
    Citation: Journal of Translational Medicine 2023 21:65
    Content type: Research Published on:

  12. Idiopathic membranous nephropathy (IMN) is a common cause of adult nephrotic syndrome. Currently, the diagnosis of IMN mainly depends on renal biopsy, which is invasive. What’s more, markers already known for ...

    Authors: Qianyu Li, Mingzhu Xu, Zhiping Zhang, Min Yin, Yucheng Zhang and Feng Liu
    Citation: Journal of Translational Medicine 2022 20:607
    Content type: Research Published on:

  13. Zinc finger and bric-a-brac/tramtrack/broad (ZBTB) domain-containing proteins have been reported to be associated with many tumors’ development. However, in tumor initiation and progression, the role of ZBTB9,...

    Authors: Zhenshan Zhang, Leilei Wu, Juan Li, Jiayan Chen, Qi Yu, Hui Yao, Yaping Xu and Liang Liu
    Citation: Journal of Translational Medicine 2022 20:602
    Content type: Research Published on:

  14. Accumulating evidence supports the implication of circular RNAs (circRNAs) in systemic lupus erythematosus (SLE). However, little is known about the detailed mechanisms and roles of circRNAs in the pathogenesi...

    Authors: Xingwang Zhao, Rui Dong, Zhongwei Tang, Juan Wang, Chunyou Wang, Zhiqiang Song, Bing Ni, Longlong Zhang, Xiaochong He and Yi You
    Citation: Journal of Translational Medicine 2022 20:547
    Content type: Research Published on:

  15. Non-small cell lung cancer (NSCLC) is the most widely distributed tumor in the world, and its immunotherapy is not practical. Neutrophil is one of a tumor’s most abundant immune cell groups. This research aime...

    Authors: Jianyu Pang, Qian Yu, Yongzhi Chen, Hongjun Yuan, Miaomiao Sheng and Wenru Tang
    Citation: Journal of Translational Medicine 2022 20:531
    Content type: Research Published on:

  16. COVID-19 infections could be complicated by acute respiratory distress syndrome (ARDS), increasing mortality risk. We sought to assess the methylome of peripheral blood mononuclear cells in COVID-19 with ARDS.

    Authors: Martina Bradic, Sarah Taleb, Binitha Thomas, Omar Chidiac, Amal Robay, Nessiya Hassan, Joel Malek, Ali Ait Hssain and Charbel Abi Khalil
    Citation: Journal of Translational Medicine 2022 20:526
    Content type: Research Published on:

  17. Facioscapulohumeral muscular dystrophy (FSHD) is an autosomal dominant muscular disorder characterized by asymmetric muscle wasting and weakness. FSHD can be subdivided into two types: FSHD1, caused by contrac...

    Authors: Yosuke Hiramuki, Yuriko Kure, Yoshihiko Saito, Megumu Ogawa, Keiko Ishikawa, Madoka Mori-Yoshimura, Yasushi Oya, Yuji Takahashi, Dae-Seong Kim, Noriko Arai, Chiaki Mori, Tsuyoshi Matsumura, Tadanori Hamano, Kenichiro Nakamura, Koji Ikezoe, Shinichiro Hayashi…
    Citation: Journal of Translational Medicine 2022 20:517
    Content type: Research Published on:

  21. Diverse drug vulnerabilities owing to the Chromatin regulators (CRs) genetic interaction across various cancers, but the identification of CRs genetic interaction remains challenging.

    Authors: Bo Chen, Pengfei Li, Mingyue Liu, Kaidong Liu, Min Zou, Yiding Geng, Shuping Zhuang, Huanhuan Xu, Linzhu Wang, Tingting Chen, Yawei Li, Zhangxiang Zhao, Lishuang Qi and Yunyan Gu
    Citation: Journal of Translational Medicine 2022 20:438
    Content type: Research Published on:

  23. Long non-coding RNAs (lncRNAs) are closely related to the occurrence and development of cancer. Abnormally expressed lncRNA can be used as a diagnostic marker for cancer. In this study, we aim to investigate t...

    Authors: Jun Wang, Yuan Xiang, Sheng-Xi Yang, Hui-Min Zhang, Hui Li, Qi-Bei Zong, Le-Wei Li, Li-Li Zhao, Ruo-Han Xia, Chao Li, Le-Yuan Bao, Tong-Cun Zhang and Xing-Hua Liao
    Citation: Journal of Translational Medicine 2022 20:426
    Content type: Research Published on:

  24. Next generation sequencing (NGS) of human specimen is expected to improve prognosis and diagnosis of human diseases, but its sensitivity urges for well-defined sampling and standardized protocols in order to a...

    Authors: Uwe Michel, Orr Shomroni, Barbara Müller, Peter Lange, Gabriela Salinas, Mathias Bähr and Jan Christoph Koch
    Citation: Journal of Translational Medicine 2022 20:413
    Content type: Research Published on:

  25. Microparticles (MPs) are 100–1000 nm heterogeneous submicron membranous vesicles derived from various cell types that express surface proteins and antigenic profiles suggestive of their cellular origin. MPs co...

    Authors: Yu Liu, Sufei Wang, Hui Xia, Xueyun Tan, Siwei Song, Shujing Zhang, Daquan Meng, Qing Chen and Yang Jin
    Citation: Journal of Translational Medicine 2022 20:404
    Content type: Review Published on:

  26. Peripheral biomarkers are increasingly vital non-invasive methods for monitoring coronary artery disease (CAD) progression. Their superiority in early detection, prognosis evaluation and classified diagnosis i...

    Authors: Xiaoteng Feng, Yifan Zhang, Min Du, Sijin Li, Jie Ding, Jiarou Wang, Yiru Wang and Ping Liu
    Citation: Journal of Translational Medicine 2022 20:399
    Content type: Research Published on:

  27. Fibroproliferative repair starts early in the inflammatory phase of acute respiratory distress syndrome (ARDS) and indicates a poor prognosis. Lumican, a small leucine-rich proteoglycan, is implicated in homeo...

    Authors: Ke Wang, Youyu Wang, Yufang Cao, Hao Wang, Yongfang Zhou, Lijuan Gao, Zijian Zeng, Mengxin Cheng, Xiaodong Jin, Jun Chen, Fuqiang Wen and Tao Wang
    Citation: Journal of Translational Medicine 2022 20:392
    Content type: Research Published on:

  29. Precision medicine incorporating genetic profiling is becoming a standard of care in medical oncology. However, in the field of radiation oncology there is limited use of genetic profiling and the impact of ge...

    Authors: Ida Deichaite, Austin Hopper, Lena Krockenberger, Timothy J. Sears, Leisa Sutton, Xenia Ray, Andrew Sharabi, Ami Navon, Parag Sanghvi, Hannah Carter and Vitali Moiseenko
    Citation: Journal of Translational Medicine 2022 20:360
    Content type: Research Published on:

  30. Aberrant glycosylation has been recognized as a hallmark of cancer and N-glycosylation is one of the main types of glycosylation in eukaryotes. Although N-glycoproteomics has made contributions to the discover...

    Authors: Yingzhen Gao, Liuyi Shen, Tianyue Dong, Xin Yang, Heyang Cui, Yanlin Guo, Yanchun Ma, Pengzhou Kong, Xiaolong Cheng, Ling Zhang and Yongping Cui
    Citation: Journal of Translational Medicine 2022 20:285
    Content type: Research Published on:

  31. Senescent cells have been identified in the aging prostate, and the senescence-associated secretory phenotype might be linked to prostate cancer (PCa). Thus, we established a cellular senescence-related gene p...

    Authors: Dechao Feng, Dengxiong Li, Xu Shi, Qiao Xiong, Facai Zhang, Qiang Wei and Lu Yang
    Citation: Journal of Translational Medicine 2022 20:252
    Content type: Research Published on:

  32. Extracellular vesicle (EV)-microRNAs (miRNAs) are potential biomarkers for various renal diseases. This study attempted to identify the circulating EV-miRNA signature not only for discriminating idiopathic mem...

    Authors: In O. Sun, Yun-Ui Bae, Haekyung Lee, Hyoungnae Kim, Jin Seok Jeon, Hyunjin Noh, Jong-Soo Choi, Kyung-Oh Doh and Soon Hyo Kwon
    Citation: Journal of Translational Medicine 2022 20:224
    Content type: Research Published on:

  33. Platinum-based chemotherapies are currently the first-line treatment of non-small cell lung cancer. This study will improve our understanding of the causes of resistance to cisplatin, especially in lung adeno...

    Authors: Qihai Sui, Zhencong Chen, Zhengyang Hu, Yiwei Huang, Jiaqi Liang, Guoshu Bi, Yunyi Bian, Mengnan Zhao, Cheng Zhan, Zongwu Lin, Qun Wang and Lijie Tan
    Citation: Journal of Translational Medicine 2022 20:171
    Content type: Research Published on:

  34. The kallikrein-kinin system is assumed to have a multifunctional role in health and disease, but its in vivo role in humans currently remains unclear owing to the divergence of plasma kinin level data publishe...

    Authors: Tanja Gangnus, Anke Bartel and Bjoern B. Burckhardt
    Citation: Journal of Translational Medicine 2022 20:146
    Content type: Research Published on:

  35. To identify the critical genes in the onset and progression of Immunoglobulin A nephropathy (IgAN) and to explore its immune cell infiltration feature.

    Authors: Jie Xu, Xiahong Shen, Xing Wei, Jie Ding, Jiaojiao Yuan, Zhen Weng and Yang He
    Citation: Journal of Translational Medicine 2022 20:145
    Content type: Research Published on:

  36. The effect of the cytochrome P450 oxidoreductase (POR) rs10954732 (G > A) polymorphism on hepatocellular carcinoma (HCC) susceptibility is unknown. Here we found that A allele carriers showed a 69% decrease in su...

    Authors: Yan Fang, Hongming Yang, Guiming Hu, Jiakun Lu, Jun Zhou, Na Gao, Yuhan Gu, Cunzhen Zhang, Jinhuan Qiu, Yuanyuan Guo, Yunfei Zhang, Qiang Wen and Hailing Qiao
    Citation: Journal of Translational Medicine 2022 20:88
    Content type: Research Published on:

  37. Emerging evidences have indicated that the aberrant liquid–liquid phase separation (LLPS) leads to the dysfunction of biomolecular condensates, thereby contributing to the tumorigenesis and progression. Nevert...

    Authors: Jianglin Zheng, Zhipeng Wu, Yue Qiu, Xuan Wang and Xiaobing Jiang
    Citation: Journal of Translational Medicine 2022 20:55
    Content type: Research Published on:

  38. Cumulative evidence indicates that the abnormal regulation of the NEDD4 family of E3-ubiquitin ligases participates in the tumorigenesis and development of cancer. However, their role in lung adenocarcinoma (L...

    Authors: Guoyin Li, Zewen Song, Changjing Wu, XiaoYan Li, Liping Zhao, Binghua Tong, Zhenni Guo, Meiqing Sun, Jin Zhao, Huina Zhang, Lintao Jia, Shengqing Li and Lei Wang
    Citation: Journal of Translational Medicine 2022 20:47
    Content type: Research Published on:

  39. Morphea is an autoimmune, sclerosing skin disorder. Despite the recent emphasis on immune dysregulation in morphea, the role of autoantibodies in morphea pathogenesis or utility as biomarkers are poorly defined.

    Authors: Jane L. Zhu, Ricardo T. Paniagua, Henry W. Chen, Stephanie Florez-Pollack, Elaine Kunzler, Noelle Teske, Yevgeniya Byekova Rainwater, Quan-Zhen Li, Gregory A. Hosler, Wenhao Li, Denise M. O. Ramirez, Nancy L. Monson and Heidi T. Jacobe
    Citation: Journal of Translational Medicine 2022 20:41
    Content type: Research Published on:

  40. Ovarian cancer (OC), an important cause of cancer-related death in women worldwide, is one of the most malignant cancers and is characterized by a poor prognosis. RNA-binding proteins (RBPs), a class of endoge...

    Authors: Jiangchun Wu, Yong Wu, Qinhao Guo, Simin Wang and Xiaohua Wu
    Citation: Journal of Translational Medicine 2022 20:37
    Content type: Review Published on:

  42. Cervical cancer is the most fatal gynecological carcinoma in the world. It is urgent to explore novel prognostic biomarkers and intervention targets for cervical cancer.

    Authors: Huiqiong Bao, Xiaobin Li, Zhixing Cao, Zhihong Huang, Li Chen, Mingbing Wang, Jiali Hu, Wenting Li, Hongwei Sun, Xue Jiang, Ping Mei, Huawen Li, Ligong Lu and Meixiao Zhan
    Citation: Journal of Translational Medicine 2022 20:18
    Content type: Research Published on:

  43. Gestational diabetes mellitus (GDM) seriously affects the health of mothers and babies, and there are still no effective early diagnostic markers. Therefore, it is necessary to find diagnostic biomarkers for s...

    Authors: Bao Jiang, Junfeng Zhang, Xiubin Sun, Chunyan Yang, Guanghui Cheng, Mengru Xu, Siyuan Li and Lina Wang
    Citation: Journal of Translational Medicine 2022 20:5
    Content type: Research Published on:

  44. N6-methyladenosine (m6A), the most abundant and reversible modification of mRNAs in eukaryotes, plays pivotal role in breast cancer (BC) tumorigenesis and progression. Circular RNAs (circRNAs) can act as tumor...

    Authors: Wenchang Lv, Yufang Tan, Mingchen Xiong, Chongru Zhao, Yichen Wang, Min Wu, Yiping Wu and Qi Zhang
    Citation: Journal of Translational Medicine 2021 19:527
    Content type: Research Published on:

  45. Reduced cardiovascular risk in premenopausal women has been the focus of research in recent decades. Previous hypothesis-driven experiments have highlighted the role of sex hormones on distinct inflammatory re...

    Authors: Bálint András Barta, Mihály Ruppert, Klemens Erwin Fröhlich, Miguel Cosenza-Contreras, Attila Oláh, Alex Ali Sayour, Krisztián Kovács, Gellért Balázs Karvaly, Martin Biniossek, Béla Merkely, Oliver Schilling and Tamás Radovits
    Citation: Journal of Translational Medicine 2021 19:507
    Content type: Research Published on:

  46. Diagnosing seronegative rheumatoid arthritis (RA) can be challenging due to complex diagnostic criteria. We sought to discover diagnostic biomarkers for seronegative RA cases by studying metabolomic and lipido...

    Authors: Hemi Luan, Wanjian Gu, Hua Li, Zi Wang, Lu Lu, Mengying Ke, Jiawei Lu, Wenjun Chen, Zhangzhang Lan, Yanlin Xiao, Jinyue Xu, Yi Zhang, Zongwei Cai, Shijia Liu and Wenyong Zhang
    Citation: Journal of Translational Medicine 2021 19:500
    Content type: Research Published on:

  47. Intestinal ischemia/reperfusion (I/R) injury commonly occurs during perioperative periods, resulting in high morbidity and mortality on a global scale. Dexmedetomidine (Dex) is a selective α2-agonist that is f...

    Authors: Qin Zhang, Xiao-Ming Liu, Qian Hu, Zheng-Ren Liu, Zhi-Yi Liu, Huai-Gen Zhang, Yuan-Lu Huang, Qiu-Hong Chen, Wen-Xiang Wang and Xue-Kang Zhang
    Citation: Journal of Translational Medicine 2021 19:463
    Content type: Research Published on:

  50. Although an association between the cytochrome P4502D6 (CYP2D6) *10 (100C>T) polymorphism and hepatocellular carcinoma (HCC) is known, the mechanism remains unclear. Here we aimed to explore mechanisms of CYP2...

    Authors: Guiming Hu, Fei Gao, Guanzhe Wang, Yan Fang, Yuanyuan Guo, Jun Zhou, Yuhan Gu, Cunzhen Zhang, Na Gao, Qiang Wen and Hailing Qiao
    Citation: Journal of Translational Medicine 2021 19:359
    Content type: Research Published on:
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Journal of Translational Medicine

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