Skip to main content

Disease Biomarkers

Section edited by Xiangdong Wang and Hao Fang

The Disease Biomarkers section aims to bridge the identification and validation of discovered gene or protein-based, network or dynamic network biomarkers with human diseases, patient phenotypes, or clinical applications, and accelerate the development of human disease-specific biomarkers for the early diagnosis, monitoring, evaluation, and prediction of diseases. Conditions including cancers, cardiovascular and metabolic diseases will be the focus of study. This section will promote the innovation and development of disease-specific biomarkers by integrating multidisciplinary aspects of science.

Studies considered for publication include those regarding the development of advanced biotechnologies for biomarker discovery and development, identifying biomarkers associated with the early detection of diseases, monitoring of disease severity and duration as well as patient responses to therapies, prediction of patient outcomes and the evaluation, regulation and ethics of disease biomarkers.

Featured articles

Microfluidic devices for neutrophil chemotaxis studies

Review | Wenjie Zhao et al

Plasma proteomic analysis of autoimmune hepatitis in an improved AIH mouse model

Research | Han Wang et al

Multi-omic serum biomarkers for prognosis of disease progression in prostate cancer

Research | Michael A. Kiebish et al

Page 1 of 9

  1. Inflammation and oxidative stress play an important role in the pathophysiology of inflammatory bowel disease (IBD). This study aimed to explore the effects of copper chaperone Antioxidant-1 (Atox1) on macroph...

    Authors: MingXian Chen, Yu Chen, Rui Fu, SaiYue Liu, HaiXia Li and TangBiao Shen
    Citation: Journal of Translational Medicine 2024 22:497
  2. Changes in plasma protein glycosylation are known to functionally affect proteins and to associate with liver diseases, including cirrhosis and hepatocellular carcinoma. Autoimmune hepatitis (AIH) is a liver d...

    Authors: Tamas Pongracz, Maaike Biewenga, Anna Eva Charlotte Stoelinga, Marco René Bladergroen, Simone Nicolardi, Leendert Adrianus Trouw, Manfred Wuhrer, Noortje de Haan and Bart van Hoek
    Citation: Journal of Translational Medicine 2024 22:456
  3. Characterization of shared cancer mechanisms have been proposed to improve therapy strategies and prognosis. Here, we aimed to identify shared cell–cell interactions (CCIs) within the tumor microenvironment ac...

    Authors: Yelin Zhao, Xinxiu Li, Joseph Loscalzo, Martin Smelik, Oleg Sysoev, Yunzhang Wang, A. K. M. Firoj Mahmud, Dina Mansour Aly and Mikael Benson
    Citation: Journal of Translational Medicine 2024 22:444
  4. Intestinal barrier dysfunction is a pivotal factor in sepsis progression. The mechanosensitive ion channel Piezo1 is associated with barrier function; however, its role in sepsis-induced intestinal barrier dys...

    Authors: Zimeng Yan, Lei Niu, Shangyuan Wang, Chengjin Gao and Shuming Pan
    Citation: Journal of Translational Medicine 2024 22:332
  5. A better diagnostic marker is in need to distinguish breast cancer from suspicious breast lesions. The abnormal glycosylation of haptoglobin has been documented to assist cancer diagnosis. This study aims to e...

    Authors: Linrong Li, Yali Xu, Zhizhen Lai, Dan Li, Qiang Sun, Zhili Li and Yidong Zhou
    Citation: Journal of Translational Medicine 2024 22:331
  6. Regulatory T cells (Tregs) are crucial in maintaining immune homeostasis and preventing autoimmunity and inflammation. A proportion of Treg cells can lose Foxp3 expression and become unstable under inflammatio...

    Authors: Yuankai Sun, Shiyu Lin, Hui Wang, Lei Wang, Yulu Qiu, Feifei Zhang, Nannan Hao, Fang Wang and Wenfeng Tan
    Citation: Journal of Translational Medicine 2024 22:327
  7. Propofol is a widely used anesthetic and sedative, which has been reported to exert an anti-inflammatory effect. TLR4 plays a critical role in coordinating the immuno-inflammatory response during sepsis. Wheth...

    Authors: Bo-Wei Zhou, Wen-Juan Zhang, Fang-Ling Zhang, Xiao Yang, Yu-Qi Ding, Zhi-Wen Yao, Zheng-Zheng Yan, Bing-Cheng Zhao, Xiao-Dong Chen, Cai Li and Ke-Xuan Liu
    Citation: Journal of Translational Medicine 2024 22:316
  8. Osteoarthritis (OA) is a degenerative disease characterized by chronic inflammation of the joint. As the disease progresses, patients will gradually develop symptoms such as pain, physical limitations and even...

    Authors: Chunran Pan, Fan Lu, Xiaoxia Hao, Xiaofeng Deng, Jiawei Liu, Kai Sun, Wenjie Hou, Xingru Shang, Ruimin Chi, Fengjing Guo and Tao Xu
    Citation: Journal of Translational Medicine 2024 22:286
  9. Inflammatory bowel disease (IBD) is a chronic gastrointestinal condition characterized by severe gut inflammation, commonly presenting as Crohn’s disease, ulcerative colitis or categorized as IBD- unclassified...

    Authors: Manoj Kumar, Selvasankar Murugesan, Nazira Ibrahim, Mamoun Elawad and Souhaila Al Khodor
    Citation: Journal of Translational Medicine 2024 22:284
  10. Infectious pancreatic necrosis (IPN) is a serious complication of acute pancreatitis, and early recognition and timely intervention are the keys to improving clinical outcomes. The purpose of this study was to...

    Authors: Xiangping Huang, Ling Wu, Qianhui Ouyang, Ying Huang, Lanhui Hong, Sixiang Liu, Kongzhi Yang, Ding Ning and Chao Chao Tan
    Citation: Journal of Translational Medicine 2024 22:218
  11. Primary biliary cholangitis (PBC) and autoimmune hepatitis (AIH) variant syndrome (VS) exhibit a complex overlap of AIH features with PBC, leading to poorer prognoses than those with PBC or AIH alone. The biom...

    Authors: Fan Yang, Leyu Zhou, Yi Shen, Xianglin Wang, Xiaoli Fan and Li Yang
    Citation: Journal of Translational Medicine 2024 22:214
  12. Venous thromboembolism (VTE) is a leading cause of cardiovascular mortality. The diagnosis of acute VTE is based on complex imaging exams due to the lack of biomarkers. Recent multi-omics based research has co...

    Authors: Cláudia Febra, Joana Saraiva, Fátima Vaz, João Macedo, Hamza Mohammad Al-Hroub, Mohammad Harb Semreen, Rui Maio, Vitor Gil, Nelson Soares and Deborah Penque
    Citation: Journal of Translational Medicine 2024 22:200
  13. Diagnosis of colorectal cancer (CRC) during early stages can greatly improve patient outcome. Although technical advances in the field of genomics and proteomics have identified a number of candidate biomarker...

    Authors: Hanju Hua, Tingting Wang, Liangxuan Pan, Xiaoyao Du, Tianxue Xia, Zhenzhong Fa, Lei Gu, Fei Gao, Chaohui Yu, Feng Gao, Lujian Liao and Zhe Shen
    Citation: Journal of Translational Medicine 2024 22:188
  14. Treatment responses to biologic agents vary between patients with moderate to severe psoriasis; while some patients achieve total skin clearance (TSC), a proportion of patients may only experience partial impr...

    Authors: Yuxiong Jiang, Dawei Huang, Qianyu Chen, Yingyuan Yu, Yifan Hu, Yu Wang, Rongfen Chen, Lingling Yao, Xiaoyuan Zhong, Luyang Kong, Qian Yu, Jiajing Lu, Ying Li and Yuling Shi
    Citation: Journal of Translational Medicine 2024 22:121
  15. Inflammatory Bowel Diseases (IBD), an autoimmune disease characterised by abnormal intestinal immunity, are related to vital morbidity around the world. However, therapeutic agents for IBD have not achieved de...

    Authors: Teming Li, Ben Han, Liucan Wang, Lihua Sun, Yujiao Cai, Min Yu, Weidong Xiao and Hua Yang
    Citation: Journal of Translational Medicine 2024 22:78
  16. No single marker of bladder cancer (BC) exists in urine samples with sufficient accuracy for disease diagnosis and treatment monitoring. The multiplex Oncuria BC assay noninvasively quantifies the concentratio...

    Authors: Hideki Furuya, Toru Sakatani, Sunao Tanaka, Kaoru Murakami, Richard T. Waldron, Wayne Hogrefe and Charles J. Rosser
    Citation: Journal of Translational Medicine 2024 22:8
  17. Chronic itch (chronic pruritus) is a major therapeutic challenge that remains poorly understood despite the extensive recent analysis of human pruriceptors. It is unclear how the peripheral nervous system diff...

    Authors: Andrea Fiebig, Victoria Leibl, David Oostendorf, Saskia Lukaschek, Jens Frömbgen, Maral Masoudi, Andreas E. Kremer, Marion Strupf, Peter Reeh, Miriam Düll and Barbara Namer
    Citation: Journal of Translational Medicine 2023 21:908
  18. Osteoarthritis is a degenerative joint disease. Cartilage degeneration is the earliest and most important pathological change in osteoarthritis, and persistent inflammation is one of the driving factors of car...

    Authors: Lin Wang, Hui Xu, Xin Li, Hongwei Chen, Haigang Zhang, Xunpeng Zhu, Zhijie Lin, Shilei Guo, Zhibo Bao, Haicheng Rui, Wei He and Hui Zhang
    Citation: Journal of Translational Medicine 2023 21:880
  19. ATM and ATR are two critical factors to regulate DNA damage response (DDR), and their mutations were frequently observed in different types of cancer, including non-small cell lung cancer (NSCLC). Given that t...

    Authors: Wei Wei, Fangfang Shi, Yang Xu, Yang Jiao, Ying Zhang, Qiuxiang Ou, Xue Wu, Lingyi Yang and Jinhuo Lai
    Citation: Journal of Translational Medicine 2023 21:874
  20. The Neutrophil-to-lymphocyte ratio (NLR) is a marker of poor prognosis in hospitalized older patients with different diseases, but there is still no consensus on the optimal cut-off value to identify older pat...

    Authors: Mirko Di Rosa, Jacopo Sabbatinelli, Luca Soraci, Andrea Corsonello, Anna Rita Bonfigli, Antonio Cherubini, Riccardo Sarzani, Roberto Antonicelli, Giuseppe Pelliccioni, Roberta Galeazzi, Francesca Marchegiani, Salvatore Iuorio, Daniele Colombo, Maurizio Burattini, Fabrizia Lattanzio and Fabiola Olivieri
    Citation: Journal of Translational Medicine 2023 21:835
  21. Cancer is a malignant tumor that seriously threatens human life and health. At present, the main treatment methods include surgical resection, chemotherapy, radiotherapy, and immunotherapy. However, the mechan...

    Authors: Shangming Dai, Fengjiao Li, Shuoguo Xu, Jinda Hu and Lichen Gao
    Citation: Journal of Translational Medicine 2023 21:769
  22. Acute myocardial infarction (AMI) has two clinical characteristics: high missed diagnosis and dysfunction of leukocytes. Transcriptional RNA on leukocytes is closely related to the course evolution of AMI pati...

    Authors: Lin Zhang, Yue Liu, Kaiyue Wang, Xiangqin Ou, Jiashun Zhou, Houliang Zhang, Min Huang, Zhenfang Du and Sheng Qiang
    Citation: Journal of Translational Medicine 2023 21:761
  23. There is evidence of pre-established vulnerability in individuals that increases the risk of their progression to severe disease or death, although the mechanisms causing this are still not fully understood. P...

    Authors: Felix Keller, Joachim Beige, Justyna Siwy, Alexandre Mebazaa, Dewei An, Harald Mischak, Joost P. Schanstra, Marika Mokou, Paul Perco, Jan A. Staessen, Antonia Vlahou and Agnieszka Latosinska
    Citation: Journal of Translational Medicine 2023 21:663
  24. The activation of CD8+ T cells and their trafficking to the skin through JAK-STAT signaling play a central role in the development of vitiligo. Thus, targeting this key disease pathway with innovative drugs is an...

    Authors: Yuqian Chang, Pan Kang, Tingting Cui, Weinan Guo, Weigang Zhang, Pengran Du, Xiuli Yi, Sen Guo, Tianwen Gao, Chunying Li and Shuli Li
    Citation: Journal of Translational Medicine 2023 21:434
  25. Immunocheckpoint inhibitors (ICIs) have been widely used in the clinical treatment of lung cancer. Although clinical studies and trials have shown that patients can benefit significantly after PD-1/PD-L1 block...

    Authors: Tongyuan Qu, Wenshuai Zhang, Chenhui Yan, Danyang Ren, Yalei Wang, Yuhong Guo, Qianru Guo, Jinpeng Wang, Liren Liu, Lei Han, Lingmei Li, Qiujuan Huang, Lu Cao, Zhaoxiang Ye, Bin Zhang, Qiang Zhao…
    Citation: Journal of Translational Medicine 2023 21:341
  26. Disruption of N6 methyl adenosine (m6A) modulation hampers gene expression and cellular functions, leading to various illnesses. However, the role of m6A modification in osteoarthritis (OA) synovitis remains u...

    Authors: Yuheng Lu, Hongbo Zhang, Haoyan Pan, Zhicheng Zhang, Hua Zeng, Haoyu Xie, Jianbin Yin, Wen Tang, Rengui Lin, Chun Zeng and Daozhang Cai
    Citation: Journal of Translational Medicine 2023 21:339
  27. Eukaryotic cells are segmented into multiple compartments or organelles within the cell that regulate distinct chemical and biological processes. Membrane-less organelles are membrane-less microscopic cellular...

    Authors: Qingqing Xie, Jiejuan Cheng, Wuxuan Mei, Dexing Yang, Pengfei Zhang and Changchun Zeng
    Citation: Journal of Translational Medicine 2023 21:237
  28. Cancer is a worldwide pandemic. The burden it imposes grows steadily on a global scale causing emotional, physical, and financial strains on individuals, families, and health care systems. Despite being the se...

    Authors: Siobhan Connal, James M. Cameron, Alexandra Sala, Paul M. Brennan, David S. Palmer, Joshua D. Palmer, Haley Perlow and Matthew J. Baker
    Citation: Journal of Translational Medicine 2023 21:118
  29. Cerebral small vessel disease (CSVD) is a systemic disease, affecting not only the brain, but also eyes and other organs. The total CSVD score is a tool for comprehensive evaluation of brain lesions in patient...

    Authors: Jia-lin Wang, Xue-ru Cheng, Zhao-yang Meng and Yan-ling Wang
    Citation: Journal of Translational Medicine 2023 21:65
  30. Idiopathic membranous nephropathy (IMN) is a common cause of adult nephrotic syndrome. Currently, the diagnosis of IMN mainly depends on renal biopsy, which is invasive. What’s more, markers already known for ...

    Authors: Qianyu Li, Mingzhu Xu, Zhiping Zhang, Min Yin, Yucheng Zhang and Feng Liu
    Citation: Journal of Translational Medicine 2022 20:607
  31. Zinc finger and bric-a-brac/tramtrack/broad (ZBTB) domain-containing proteins have been reported to be associated with many tumors’ development. However, in tumor initiation and progression, the role of ZBTB9,...

    Authors: Zhenshan Zhang, Leilei Wu, Juan Li, Jiayan Chen, Qi Yu, Hui Yao, Yaping Xu and Liang Liu
    Citation: Journal of Translational Medicine 2022 20:602
  32. Accumulating evidence supports the implication of circular RNAs (circRNAs) in systemic lupus erythematosus (SLE). However, little is known about the detailed mechanisms and roles of circRNAs in the pathogenesi...

    Authors: Xingwang Zhao, Rui Dong, Zhongwei Tang, Juan Wang, Chunyou Wang, Zhiqiang Song, Bing Ni, Longlong Zhang, Xiaochong He and Yi You
    Citation: Journal of Translational Medicine 2022 20:547
  33. Non-small cell lung cancer (NSCLC) is the most widely distributed tumor in the world, and its immunotherapy is not practical. Neutrophil is one of a tumor’s most abundant immune cell groups. This research aime...

    Authors: Jianyu Pang, Qian Yu, Yongzhi Chen, Hongjun Yuan, Miaomiao Sheng and Wenru Tang
    Citation: Journal of Translational Medicine 2022 20:531
  34. COVID-19 infections could be complicated by acute respiratory distress syndrome (ARDS), increasing mortality risk. We sought to assess the methylome of peripheral blood mononuclear cells in COVID-19 with ARDS.

    Authors: Martina Bradic, Sarah Taleb, Binitha Thomas, Omar Chidiac, Amal Robay, Nessiya Hassan, Joel Malek, Ali Ait Hssain and Charbel Abi Khalil
    Citation: Journal of Translational Medicine 2022 20:526
  35. Facioscapulohumeral muscular dystrophy (FSHD) is an autosomal dominant muscular disorder characterized by asymmetric muscle wasting and weakness. FSHD can be subdivided into two types: FSHD1, caused by contrac...

    Authors: Yosuke Hiramuki, Yuriko Kure, Yoshihiko Saito, Megumu Ogawa, Keiko Ishikawa, Madoka Mori-Yoshimura, Yasushi Oya, Yuji Takahashi, Dae-Seong Kim, Noriko Arai, Chiaki Mori, Tsuyoshi Matsumura, Tadanori Hamano, Kenichiro Nakamura, Koji Ikezoe, Shinichiro Hayashi…
    Citation: Journal of Translational Medicine 2022 20:517
  36. Diverse drug vulnerabilities owing to the Chromatin regulators (CRs) genetic interaction across various cancers, but the identification of CRs genetic interaction remains challenging.

    Authors: Bo Chen, Pengfei Li, Mingyue Liu, Kaidong Liu, Min Zou, Yiding Geng, Shuping Zhuang, Huanhuan Xu, Linzhu Wang, Tingting Chen, Yawei Li, Zhangxiang Zhao, Lishuang Qi and Yunyan Gu
    Citation: Journal of Translational Medicine 2022 20:438
  37. Long non-coding RNAs (lncRNAs) are closely related to the occurrence and development of cancer. Abnormally expressed lncRNA can be used as a diagnostic marker for cancer. In this study, we aim to investigate t...

    Authors: Jun Wang, Yuan Xiang, Sheng-Xi Yang, Hui-Min Zhang, Hui Li, Qi-Bei Zong, Le-Wei Li, Li-Li Zhao, Ruo-Han Xia, Chao Li, Le-Yuan Bao, Tong-Cun Zhang and Xing-Hua Liao
    Citation: Journal of Translational Medicine 2022 20:426
  38. Next generation sequencing (NGS) of human specimen is expected to improve prognosis and diagnosis of human diseases, but its sensitivity urges for well-defined sampling and standardized protocols in order to a...

    Authors: Uwe Michel, Orr Shomroni, Barbara Müller, Peter Lange, Gabriela Salinas, Mathias Bähr and Jan Christoph Koch
    Citation: Journal of Translational Medicine 2022 20:413
  39. Microparticles (MPs) are 100–1000 nm heterogeneous submicron membranous vesicles derived from various cell types that express surface proteins and antigenic profiles suggestive of their cellular origin. MPs co...

    Authors: Yu Liu, Sufei Wang, Hui Xia, Xueyun Tan, Siwei Song, Shujing Zhang, Daquan Meng, Qing Chen and Yang Jin
    Citation: Journal of Translational Medicine 2022 20:404
  40. Peripheral biomarkers are increasingly vital non-invasive methods for monitoring coronary artery disease (CAD) progression. Their superiority in early detection, prognosis evaluation and classified diagnosis i...

    Authors: Xiaoteng Feng, Yifan Zhang, Min Du, Sijin Li, Jie Ding, Jiarou Wang, Yiru Wang and Ping Liu
    Citation: Journal of Translational Medicine 2022 20:399
  41. Fibroproliferative repair starts early in the inflammatory phase of acute respiratory distress syndrome (ARDS) and indicates a poor prognosis. Lumican, a small leucine-rich proteoglycan, is implicated in homeo...

    Authors: Ke Wang, Youyu Wang, Yufang Cao, Hao Wang, Yongfang Zhou, Lijuan Gao, Zijian Zeng, Mengxin Cheng, Xiaodong Jin, Jun Chen, Fuqiang Wen and Tao Wang
    Citation: Journal of Translational Medicine 2022 20:392
  42. Precision medicine incorporating genetic profiling is becoming a standard of care in medical oncology. However, in the field of radiation oncology there is limited use of genetic profiling and the impact of ge...

    Authors: Ida Deichaite, Austin Hopper, Lena Krockenberger, Timothy J. Sears, Leisa Sutton, Xenia Ray, Andrew Sharabi, Ami Navon, Parag Sanghvi, Hannah Carter and Vitali Moiseenko
    Citation: Journal of Translational Medicine 2022 20:360

Annual Journal Metrics