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Clinical translation

Section edited by Lana Kandalaft

This section aims to allow rapid communication of innovative early phase clinical trials, where novel scientific ideas are translated to the clinic. These include clinical trials that are distinguished for their novelty in approach, design or indication, timeliness, and unique ability to translate laboratory concepts from the bench to the bedside. Manuscripts are submitted typically at the time a clinical trial has gained full regulatory approval and is being initiated. No clinical results are required. These articles review the background, rationale, clinical design and approach, translational endpoints and expected outcomes of a new clinical trial in a scholarly manner, and provide the opportunity to investigators to share their views and clinical translation efforts with a wide audience at an early stage.

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  1. Content type: Research

    To analyze the prognostic value of preoperative prognostic nutritional index (PNI) in predicting the survival outcome of hypopharyngeal squamous cell carcinoma (HPSCC) patients receiving radical surgery.

    Authors: Lu-Lu Ye, Ronald Wihal Oei, Fang-Fang Kong, Cheng-Run Du, Rui-Ping Zhai, Qing-Hai Ji, Chao-Su Hu and Hong-Mei Ying

    Citation: Journal of Translational Medicine 2018 16:12

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  2. Content type: Research

    Alveolar cleft repair is performed via bone grafting procedure to restore the dental arch continuity. A suitable bone substitute materials should possess osteoinductive and osteoconductive properties, to promo...

    Authors: Mohammad Kamal, Lars Andersson, Rene Tolba, Adel Al-Asfour, Alexander K. Bartella, Felix Gremse, Stefanie Rosenhain, Frank Hölzle, Peter Kessler and Bernd Lethaus

    Citation: Journal of Translational Medicine 2017 15:263

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  3. Content type: Research

    Coexistence of enhancer of zeste homolog 2 (EZH2) and BRAF gene aberrations has been described in many cancer types. In this study, we aim to explore the coexistence status of BRAF V600E mutation and the copy num...

    Authors: Huan Yu, Meng Ma, Junya Yan, Longwen Xu, Jiayi Yu, Jie Dai, Tianxiao Xu, Huan Tang, Xiaowen Wu, Siming Li, Bin Lian, Lili Mao, Zhihong Chi, Chuanliang Cui, Jun Guo and Yan Kong

    Citation: Journal of Translational Medicine 2017 15:243

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  4. Content type: Research

    Evidence supports the existence of different subphenotypes in systemic lupus erythematosus (SLE) and the pivotal role of cytokines and autoantibodies, which interact in a highly complex network. Thus, understa...

    Authors: Yovana Pacheco, Julián Barahona-Correa, Diana M. Monsalve, Yeny Acosta-Ampudia, Manuel Rojas, Yhojan Rodríguez, Juliana Saavedra, Mónica Rodríguez-Jiménez, Rubén D. Mantilla, Carolina Ramírez-Santana, Nicolás Molano-González and Juan-Manuel Anaya

    Citation: Journal of Translational Medicine 2017 15:239

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  5. Content type: Review

    Medical imaging has become a central component of patient care to ensure early and accurate diagnosis. Unfortunately, many imaging modalities use ionizing radiation to generate images. Ionizing radiation even ...

    Authors: Tyler A. Smith, Daniel R. Kirkpatrick, Sean Smith, Trevor K. Smith, Tate Pearson, Aparna Kailasam, Kortney Z. Herrmann, Johanna Schubert and Devendra K. Agrawal

    Citation: Journal of Translational Medicine 2017 15:232

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  6. Content type: Commentary

    Immunotherapies have emerged as one of the most promising approaches to treat patients with cancer. Recently, the entire medical oncology field has been revolutionized by the introduction of immune checkpoints...

    Authors: Giuseppe V. Masucci, Alessandra Cesano, Alexander Eggermont, Bernard A. Fox, Ena Wang, Francesco M. Marincola, Gennaro Ciliberto, Kevin Dobbin, Igor Puzanov, Janis Taube, Jennifer Wargo, Lisa H. Butterfield, Lisa Villabona, Magdalena Thurin, Michael A. Postow, Paul M. Sondel…

    Citation: Journal of Translational Medicine 2017 15:223

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  7. Content type: Research

    Pigs have many features that make them attractive as biomedical models for various diseases, including cancer. P53 is an important tumor suppressor gene that exerts a central role in protecting cells from onco...

    Authors: Youfeng Shen, Kaixiang Xu, Zaimei Yuan, Jianxiong Guo, Heng Zhao, Xuezeng Zhang, Lu Zhao, Yubo Qing, Honghui Li, Weirong Pan, Baoyu Jia, Hong-Ye Zhao and Hong-Jiang Wei

    Citation: Journal of Translational Medicine 2017 15:224

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  8. Content type: Research

    Microparticles (MPs) are small (<1 μm) cell membrane-derived vesicles that are formed in response to cellular activation or early stages of apoptosis. Increased plasma MP levels have been associated with liver...

    Authors: Cornelius Engelmann, Katrin Splith, Sandra Krohn, Adam Herber, Albrecht Boehlig, Stephan Boehm, Johann Pratschke, Thomas Berg and Moritz Schmelzle

    Citation: Journal of Translational Medicine 2017 15:188

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  9. Content type: Research

    Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are severe inflammatory lung diseases. Methylprednisolone (MP) is a common drug against inflammation in clinic. In this study, we aim to i...

    Authors: Guo-wei Tu, Yi Shi, Yi-jun Zheng, Min-jie Ju, Hong-yu He, Guo-guang Ma, Guang-wei Hao and Zhe Luo

    Citation: Journal of Translational Medicine 2017 15:181

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  10. Content type: Research

    Red blood cell (RBC) depletion is a standard graft manipulation technique for ABO-incompatible bone marrow (BM) transplants. The BM processing module for Spectra Optia, “BMC”, was previously introduced. We her...

    Authors: Soo-Zin Kim-Wanner, Gesine Bug, Juliane Steinmann, Salem Ajib, Nadine Sorg, Carolin Poppe, Milica Bunos, Eva Wingenfeld, Christiane Hümmer, Beate Luxembourg, Erhard Seifried and Halvard Bonig

    Citation: Journal of Translational Medicine 2017 15:174

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  11. Content type: Review

    Most modern societies undergo rapid population aging. The rise in life expectancy, nevertheless, is not accompanied, to date, by the same increment of healthspan. Efforts to increase healthspan by means of sup...

    Authors: Alexander Vaiserman and Oleh Lushchak

    Citation: Journal of Translational Medicine 2017 15:160

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  12. Content type: Review

    While many decades of scientific research studies have gone into harnessing the power of the immune system to fight cancer, only recently have cancer immunotherapeutic approaches begun to show robust clinical ...

    Authors: Mohammad Haris, Puneet Bagga, Hari Hariharan, Bevin McGettigan-Croce, Laura A. Johnson and Ravinder Reddy

    Citation: Journal of Translational Medicine 2017 15:140

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  13. Content type: Review

    Many cancers, including breast cancer, have demonstrated prognosis and support advantages thanks to the discovery of targeted therapies. The advent of these new approaches marked the rise of precision medicine...

    Authors: Ali Bettaieb, Catherine Paul, Stéphanie Plenchette, Jingxuan Shan, Lotfi Chouchane and François Ghiringhelli

    Citation: Journal of Translational Medicine 2017 15:139

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  14. Content type: Review

    The pursuit for clarity in diagnostic and treatment pathways for the complex, chronic condition of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) continues. This systematic review raises a novel q...

    Authors: Amy Wallis, Michelle Ball, Sandra McKechnie, Henry Butt, Donald P. Lewis and Dorothy Bruck

    Citation: Journal of Translational Medicine 2017 15:129

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  15. Content type: Research

    Cell cycle dysregulation is common in human malignancies, and CDK4/6 inhibitors targeting cell cycle have potential antitumor activity. SHR6390 is a novel small molecule inhibitor specifically targeting the CD...

    Authors: Jiayuan Wang, Qingqing Li, Jiajia Yuan, Jingyuan Wang, Zuhua Chen, Zhentao Liu, Zhongwu Li, Yumei Lai, Jing Gao and Lin Shen

    Citation: Journal of Translational Medicine 2017 15:127

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  16. Content type: Research

    Electrochemotherapy (ECT), by combining manageable cytotoxic agents with short electric pulses, represents an effective palliative skin-directed therapy. The accumulated evidence indicates that ECT stands out ...

    Authors: Luca G. Campana, Roberto Marconato, Sara Valpione, Sara Galuppo, Mauro Alaibac, Carlo R. Rossi and Simone Mocellin

    Citation: Journal of Translational Medicine 2017 15:122

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  17. Content type: Research

    Metabolic syndrome (MetS) increases the risk of morbidity and mortality from cardiovascular disease, and exercise training is an important factor in the treatment and prevention of the clinical components of M...

    Authors: Robinson Ramírez-Vélez, Alejandra Tordecilla-Sanders, Luis Andrés Téllez-T, Diana Camelo-Prieto, Paula Andrea Hernández-Quiñonez, Jorge Enrique Correa-Bautista, Antonio Garcia-Hermoso, Rodrigo Ramirez-Campillo and Mikel Izquierdo

    Citation: Journal of Translational Medicine 2017 15:118

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    The Erratum to this article has been published in Journal of Translational Medicine 2017 15:136

  18. Content type: Research

    Image contrast enhanced by exogenous contrast agents plays a crucial role in the early detection, characterization, and determination of the precise location of cancers. Here, we investigate the feasibility of...

    Authors: Puneet Bagga, Mohammad Haris, Kevin D’Aquilla, Neil E. Wilson, Francesco M. Marincola, Mitchell D. Schnall, Hari Hariharan and Ravinder Reddy

    Citation: Journal of Translational Medicine 2017 15:119

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  19. Content type: Commentary

    Recent advances in molecular biology have revolutionized the concept of KIT/PDGFRA wild type (WT) gastrointestinal stromal tumors (GIST) than the past. Indeed, from being defined as GIST without KIT or PDGFRA ...

    Authors: Margherita Nannini, Milena Urbini, Annalisa Astolfi, Guido Biasco and Maria A. Pantaleo

    Citation: Journal of Translational Medicine 2017 15:113

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    The Erratum to this article has been published in Journal of Translational Medicine 2017 15:125

  20. Content type: Research

    Evidence shows that Luminal A breast cancer is likely to undergo bone metastasis, but the mechanisms involved remain unknown. This study’s aim was to demonstrate a correlation between estrogen receptor (ER) po...

    Authors: Jen-Hwey Chiu, Che-Sheng Wen, Jir-You Wang, Chih-Yi Hsu, Yi-Fang Tsai, Shih-Chieh Hung, Ling-Ming Tseng and Yi-Ming Shyr

    Citation: Journal of Translational Medicine 2017 15:97

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  21. Content type: Research

    Cell necrosis, oxidative damage, and fibrogenesis are involved in cirrhosis development, a condition in which insulin-like growth factor 1 (IGF-1) levels are diminished. This study evaluates whether the exogen...

    Authors: Luis A. Morales-Garza, Juan E. Puche, Gabriel A. Aguirre, Úrsula Muñoz, Mariano García-Magariño, Rocío G. De la Garza and Inma Castilla-Cortazar

    Citation: Journal of Translational Medicine 2017 15:96

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  22. Content type: Research

    Immunohistochemistry (IHC) and fluorescent-in situ hybridization (FISH) are standard methods to assess human epidermal growth factor receptor 2 (HER2) status in breast cancer (BC) patients. Real-time quantitat...

    Authors: Gabriele Zoppoli, Anna Garuti, Gabriella Cirmena, Ludovica Verdun di Cantogno, Cristina Botta, Maurizio Gallo, Domenico Ferraioli, Enrico Carminati, Paola Baccini, Monica Curto, Piero Fregatti, Edoardo Isnaldi, Michela Lia, Roberto Murialdo, Daniele Friedman, Anna Sapino…

    Citation: Journal of Translational Medicine 2017 15:91

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  23. Content type: Research

    Patients with hereditary diffuse gastric cancer (HDGC), a cancer predisposition syndrome associated with germline mutations of the CDH1 (E-cadherin) gene, have few effective treatment options. Despite marked d...

    Authors: Ina Chen, Lesley Mathews-Greiner, Dandan Li, Abisola Abisoye-Ogunniyan, Satyajit Ray, Yansong Bian, Vivek Shukla, Xiaohu Zhang, Raj Guha, Craig Thomas, Berkley Gryder, Athina Zacharia, Joal D. Beane, Sarangan Ravichandran, Marc Ferrer and Udo Rudloff

    Citation: Journal of Translational Medicine 2017 15:92

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  24. Content type: Research

    TREM-1 acts as an amplifier of inflammation expressed on macrophages. The objective of this study was to evaluate the relationship between TREM-1 and macrophage polarization, and association of TREM-1 and M1 m...

    Authors: Saravanan Subramanian, Pradeep K. Pallati, Poonam Sharma, Devendra K. Agrawal and Kalyana C. Nandipati

    Citation: Journal of Translational Medicine 2017 15:85

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  25. Content type: Research

    Oxylipins are potent lipid mediators demonstrated to initiate and regulate inflammation yet little is known regarding their involvement in the response to surgical trauma. As key modulators of the inflammatory...

    Authors: Arnaud M. Wolfer, Alasdair J. Scott, Claudia Rueb, Mathieu Gaudin, Ara Darzi, Jeremy K. Nicholson, Elaine Holmes and James M. Kinross

    Citation: Journal of Translational Medicine 2017 15:83

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  26. Content type: Research

    The O 6 -methylguanine methyltransferase (MGMT) gene is frequently unmethylated in patients with glioblastoma (GBM), rendering them non-responsive...

    Authors: Toni Rose Jue, Kyoko Nozue, Ashleigh J. Lester, Swapna Joshi, Lisette B. W. Schroder, Shane P. Whittaker, Sheri Nixdorf, Robert W. Rapkins, Mustafa Khasraw and Kerrie L. McDonald

    Citation: Journal of Translational Medicine 2017 15:61

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  27. Content type: Research

    Malignant mesothelioma (MM) is a very aggressive type of cancer, with a dismal prognosis and inherent resistance to chemotherapeutics. Development and evaluation of new therapeutic approaches is highly needed....

    Authors: Agata Szymiczek, Sandra Pastorino, David Larson, Mika Tanji, Laura Pellegrini, Jiaming Xue, Shuangjing Li, Carlotta Giorgi, Paolo Pinton, Yasutaka Takinishi, Harvey I. Pass, Hideki Furuya, Giovanni Gaudino, Andrea Napolitano, Michele Carbone and Haining Yang

    Citation: Journal of Translational Medicine 2017 15:58

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  28. Content type: Research

    Gastric cancer (GC) is one of the most malignant tumors and the second leading cause of cancer-related deaths in the world. Luteolin, a flavonoid present in many fruits and green plants, suppresses cancer prog...

    Authors: Ming-de Zang, Lei Hu, Zhi-yuan Fan, He-xiao Wang, Zheng-lun Zhu, Shu Cao, Xiong-yan Wu, Jian-fang Li, Li-ping Su, Chen Li, Zheng-gang Zhu, Min Yan and Bing-ya Liu

    Citation: Journal of Translational Medicine 2017 15:52

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  29. Content type: Research

    The purpose of the present study was to develop an animal model for creating alveolar cleft defects with properly simulated clinical defect environment for tissue-engineered bone-substitute materials testing w...

    Authors: Mohammad Kamal, Lars Andersson, Rene Tolba, Alexander Bartella, Felix Gremse, Frank Hölzle, Peter Kessler and Bernd Lethaus

    Citation: Journal of Translational Medicine 2017 15:50

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  30. Content type: Methodology

    Operational tolerance is an alternative to lifelong immunosuppression after transplantation. One strategy to achieve tolerance is by T regulatory cells. Safety and feasibility of a T regulatory type 1 (Tr1)-ce...

    Authors: Bechara Mfarrej, Eleonora Tresoldi, Angela Stabilini, Alessia Paganelli, Rossana Caldara, Antonio Secchi and Manuela Battaglia

    Citation: Journal of Translational Medicine 2017 15:40

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  31. Content type: Research

    Macrophages (Mφs) constitute a major component of the leukocyte infiltrate and perform distinct roles in different tumor microenvironments. This study aimed to characterize the distribution, composition and pr...

    Authors: Jin-Qing Li, Xing-Juan Yu, Yong-Chun Wang, Li-Yun Huang, Chao-Qun Liu, Limin Zheng, Yu-jing Fang and Jing Xu

    Citation: Journal of Translational Medicine 2017 15:37

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  32. Content type: Methodology

    Pathologic lymph node staging is becoming a deficient method in the demanding molecular era. Nevertheless, the use of more sensitive molecular analysis for nodal staging is hampered by its high costs and exte...

    Authors: Natalia Rakislova, Carla Montironi, Iban Aldecoa, Eva Fernandez, Josep Antoni Bombi, Mireya Jimeno, Francesc Balaguer, Maria Pellise, Antoni Castells and Miriam Cuatrecasas

    Citation: Journal of Translational Medicine 2017 15:14

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  33. Content type: Research

    Kidney transplantation is the most effective treatment for end-stage renal disease. Sensitization refers to pre-existing antibodies against human leukocyte antigen (HLA) protein and remains a major barrier to ...

    Authors: John F. Beausang, H. Christina Fan, Rene Sit, Maria U. Hutchins, Kshama Jirage, Rachael Curtis, Edward Hutchins, Stephen R. Quake and Julie M. Yabu

    Citation: Journal of Translational Medicine 2017 15:9

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  34. Content type: Methodology

    Rare nucleated CD45 negative cells in peripheral blood may be malignant such as circulating tumor cells. Untouched isolation thereof by depletion of normal is favored yet still technological challenging. We op...

    Authors: Stefan Schreier, Piamsiri Sawaisorn, Rachanee Udomsangpetch and Wannapong Triampo

    Citation: Journal of Translational Medicine 2017 15:6

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  35. Content type: Research

    Certain disadvantages of the standard hematopoietic stem and progenitor cell (HSPC) mobilizing agent G-CSF fuel the quest for alternatives. We herein report results of a Phase I dose escalation trial comparing...

    Authors: Darja Karpova, Susanne Bräuninger, Eliza Wiercinska, Ariane Krämer, Belinda Stock, Jochen Graff, Hans Martin, Achim Wach, Christophe Escot, Garry Douglas, Barbara Romagnoli, Eric Chevalier, Klaus Dembowski, Leon Hooftman and Halvard Bonig

    Citation: Journal of Translational Medicine 2017 15:2

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  36. Content type: Research

    Mantle cell lymphoma (MCL) is considered an aggressive subtype of non-Hodgkin’s lymphoma with variable treatment responses. There is an urgent need to identify novel markers with prognostic and therapeutic val...

    Authors: Xin Wang, Lalit Sehgal, Neeraj Jain, Tamer Khashab, Rohit Mathur and Felipe Samaniego

    Citation: Journal of Translational Medicine 2016 14:346

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  37. Content type: Commentary

    End goal of translational medicine is to combine disciplines and expertise to eventually promote improvement of the global healthcare system by delivering effective therapies to individuals and society. Well-t...

    Authors: Alessandra Petrelli, Berent J. Prakken and Norman D. Rosenblum

    Citation: Journal of Translational Medicine 2016 14:329

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  38. Content type: Research

    Local implantation of ex vivo concentrated, washed and filtrated human bone marrow-derived mononuclear cells (BMC) seeded onto β-tricalciumphosphate (TCP) significantly enhanced bone healing in a preclinical s...

    Authors: Caroline Seebach, Dirk Henrich, Simon Meier, Christoph Nau, Halvard Bonig and Ingo Marzi

    Citation: Journal of Translational Medicine 2016 14:314

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  39. Content type: Research

    The pre-treatment with α-tocopherol inhibits progression of rat liver proliferation induced by partial hepatectomy (PH), by decreasing and/or desynchronizing cyclin D1 expression and activation into the nucleu...

    Authors: Lourdes Sánchez-Sevilla, Edgar Mendieta-Condado and Rolando Hernández-Muñoz

    Citation: Journal of Translational Medicine 2016 14:307

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  40. Content type: Research

    Mechanical ventilation (MV) during a cardio-thoracic surgery contributes to diaphragm muscle dysfunction that impairs weaning and can lead to the ventilator- induced diaphragm dysfunction. Especially, it is cr...

    Authors: Robert T. Mankowski, Shakeel Ahmed, Thomas Beaver, Marvin Dirain, Chul Han, Phillip Hess, Tomas Martin, Barbara K. Smith, Shinichi Someya, Christiaan Leeuwenburgh and A. Daniel Martin

    Citation: Journal of Translational Medicine 2016 14:305

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  41. Content type: Research

    Certain glomerulopathies are associated with increased levels of CD80 (B7-1). We measured the urinary excretion of CD80, podocyturia and proteinuria in controls and in subjects with Fabry disease either untrea...

    Authors: H. Trimarchi, R. Canzonieri, A. Schiel, C. Costales-Collaguazo, J. Politei, A. Stern, M. Paulero, T. Rengel, J. Andrews, M. Forrester, M. Lombi, V. Pomeranz, R. Iriarte, A. Muryan, E. Zotta, M. D. Sanchez-Niño…

    Citation: Journal of Translational Medicine 2016 14:289

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  42. Content type: Research

    Patients with lower extremity peripheral artery disease (PAD) have decreased mobility, which is not fully explained by impaired blood supply to the lower limb. Additionally, reports are conflicted regarding fi...

    Authors: Sarah H. White, Mary M. McDermott, Robert L. Sufit, Kate Kosmac, Alex W. Bugg, Marta Gonzalez-Freire, Luigi Ferrucci, Lu Tian, Lihui Zhao, Ying Gao, Melina R. Kibbe, Michael H. Criqui, Christiaan Leeuwenburgh and Charlotte A. Peterson

    Citation: Journal of Translational Medicine 2016 14:284

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    The Erratum to this article has been published in Journal of Translational Medicine 2017 15:45

  43. Content type: Research

    Ischemia reperfusion injury (IRI) induced immune response is a critical issue in transplantation. Complement and contact system activation are among its key mechanisms.

    Authors: Pierre-Olivier Delpech, Raphael Thuillier, Thibault SaintYves, Jerome Danion, Sylvain Le Pape, Edwin S. van Amersfoort, Beatrijs Oortwijn, Gilles Blancho and Thierry Hauet

    Citation: Journal of Translational Medicine 2016 14:277

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  44. Content type: Research

    To investigate the effect of perfluorochemical preparations in enhancing radiotherapy, perfluocarbon nanoparticles were by encapsulating perfluorohexane into liposome [lip(PFH)].

    Authors: Linfeng Xu, Xuefeng Qiu, Yanting Zhang, Kai Cao, Xiaozhi Zhao, Jinhui Wu, Yiqiao Hu and Hongqian Guo

    Citation: Journal of Translational Medicine 2016 14:268

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