Durcan L, Petri M. Why targeted therapies are necessary for systemic lupus erythematosus. Lupus. 2016;25:1070–9.
Article
CAS
PubMed
PubMed Central
Google Scholar
Tsokos GC, Lo MS, Costa Reis P, Sullivan KE. New insights into the immunopathogenesis of systemic lupus erythematosus. Nat Rev Rheumatol. 2016;12:716–30.
Article
CAS
PubMed
Google Scholar
Lleo A, Invernizzi P, Gao B, Podda M, Gershwin ME. Definition of human autoimmunity—autoantibodies versus autoimmune disease. Autoimmun Rev. 2010;9:A259–66.
Article
CAS
PubMed
Google Scholar
Zharkova O, Celhar T, Cravens PD, Satterthwaite AB, Fairhurst A-M, Davis LS. Pathways leading to an immunological disease: systemic lupus erythematosus. Rheumatology. 2017;56:i55–66.
Article
PubMed
PubMed Central
Google Scholar
Arbuckle MR, McClain MT, Rubertone MV, Scofield RH, Dennis GJ, James JA, et al. Development of autoantibodies before the clinical onset of systemic lupus erythematosus. N Engl J Med. 2003;349:1526–33.
Article
CAS
PubMed
Google Scholar
Banchereau R, Hong S, Cantarel B, Baldwin N, Baisch J, Edens M, et al. Personalized immunomonitoring uncovers molecular networks that stratify lupus patients. Cell. 2016;165:551–65.
Article
CAS
PubMed
PubMed Central
Google Scholar
Tan JHT, Hoh SF, Win MTM, Chan YH, Das L, Arkachaisri T. Childhood-onset systemic lupus erythematosus in Singapore: clinical phenotypes, disease activity, damage, and autoantibody profiles. Lupus. 2015;24:998–1005.
Article
CAS
PubMed
Google Scholar
Artim-Esen B, Çene E, Şahinkaya Y, Ertan S, Pehlivan Ö, Kamali S, et al. Cluster analysis of autoantibodies in 852 patients with systemic lupus erythematosus from a single center. J Rheumatol. 2014;41:1304–10.
Article
PubMed
Google Scholar
Li PH, Wong WHS, Lee TL, Lau CS, Chan TM, Leung AMH, et al. Relationship between autoantibody clustering and clinical subsets in SLE: cluster and association analyses in Hong Kong Chinese. Rheumatology. 2013;52:337–45.
Article
PubMed
Google Scholar
Ching KH, Burbelo PD, Tipton C, Wei C, Petri M, Sanz I, et al. Two major autoantibody clusters in systemic lupus erythematosus. PLoS ONE. 2012;7:e32001.
Article
CAS
PubMed
PubMed Central
Google Scholar
Tang X, Huang Y, Deng W, Tang L, Weng W, Zhang X. Clinical and serologic correlations and autoantibody clusters in systemic lupus erythematosus: a retrospective review of 917 patients in South China. Medicine (Baltimore). 2010;89:62–7.
Article
Google Scholar
Jurencák R, Fritzler M, Tyrrell P, Hiraki L, Benseler S, Silverman E. Autoantibodies in pediatric systemic lupus erythematosus: ethnic grouping, cluster analysis, and clinical correlations. J Rheumatol. 2009;36:416–21.
Article
PubMed
Google Scholar
Li QZ, Zhen QL, Xie C, Wu T, Mackay M, Aranow C, et al. Identification of autoantibody clusters that best predict lupus disease activity using glomerular proteome arrays. J Clin Invest. 2005;115:3428–39.
Article
PubMed
Google Scholar
To CH, Petri M. Is antibody clustering predictive of clinical subsets and damage in systemic lupus erythematosus? Arthritis Rheum. 2005;52:4003–10.
Article
CAS
PubMed
Google Scholar
Hoffman IEA, Peene I, Meheus L, Huizinga TWJ, Cebecauer L, Isenberg D, et al. Specific antinuclear antibodies are associated with clinical features in systemic lupus erythematosus. Ann Rheum Dis. 2004;63:1155–8.
Article
CAS
PubMed
PubMed Central
Google Scholar
Tápanes FJ, Vásquez M, Ramírez R, Matheus C, Rodríguez MA, Bianco N. Cluster analysis of antinuclear autoantibodies in the prognosis of SLE nephropathy: are anti-extractable nuclear antibodies protective? Lupus. 2000;9:437–44.
Article
PubMed
Google Scholar
Park DJ, Kang JH, Kim JE, Lee KE, Lee SS. Comparison of clinical and serological differences according to the autoantibody cluster in women with systemic lupus erythematosus: results from the Korean lupus network (KORNET) registry. Ann Rheum Dis. 2017;76(Suppl 2):SAT0275.
Google Scholar
Anaya JM. The autoimmune tautology. A summary of evidence. Joint Bone Spine. 2017;84:251–3.
Article
CAS
PubMed
Google Scholar
Anaya JM. The diagnosis and clinical significance of polyautoimmunity. Autoimmun Rev. 2014;13:423–6.
Article
CAS
PubMed
Google Scholar
Rojas-Villarraga A, Toro CE, Espinosa G, Rodríguez-Velosa Y, Duarte-Rey C, Mantilla RD, et al. Factors influencing polyautoimmunity in systemic lupus erythematosus. Autoimmun Rev. 2010;9:229–32.
Article
CAS
PubMed
Google Scholar
Anaya JM, Corena R, Castiblanco J, Rojas-Villarraga A, Shoenfeld Y. The kaleidoscope of autoimmunity: multiple autoimmune syndromes and familial autoimmunity. Expert Rev Clin Immunol. 2007;3:623–35.
Article
CAS
PubMed
Google Scholar
Amaya-Amaya J, Molano-González N, Franco JS, Rodríguez-Jiménez M, Rojas-Villarraga A, Anaya JM. Anti-CCP antibodies as a marker of rhupus. Lupus. 2015;24:892–4.
Article
CAS
PubMed
Google Scholar
Franco JS, Molano-González N, Rodríguez-Jiménez M, Acosta-Ampudia Y, Mantilla RD, Amaya-Amaya J, et al. The coexistence of antiphospholipid syndrome and systemic lupus erythematosus in Colombians. PLoS ONE. 2014;9:e110242.
Article
PubMed
PubMed Central
Google Scholar
Franco JS, Amaya-Amaya J, Molano-González N, Caro-Moreno J, Rodríguez-Jiménez M, Acosta-Ampudia Y, et al. Autoimmune thyroid disease in Colombian patients with systemic lupus erythematosus. Clin Endocrinol (Oxf). 2015;83:943–50.
Article
CAS
PubMed
Google Scholar
Davis LS, Reimold AM. Research and therapeutics-traditional and emerging therapies in systemic lupus erythematosus. Rheumatology. 2017;56:i100–13.
Article
PubMed
Google Scholar
Brodin P, Davis MM. Human immune system variation. Nat Rev Immunol. 2017;17:21–9.
Article
CAS
PubMed
Google Scholar
Davis MM, Tato CM, Furman D. Systems immunology: just getting started. Nat Immunol. 2017;18:725–32.
Article
CAS
PubMed
Google Scholar
American College of Rheumatology Ad Hoc Committee on. Systemic lupus erythematosus guidelines. Guidelines for referral and management of systemic lupus erythematosus in adults. Arthritis Rheum. 1999;42:1785–96.
Article
Google Scholar
Johar AS, Mastronardi C, Rojas-Villarraga A, Patel HR, Chuah A, Peng K, et al. Novel and rare functional genomic variants in multiple autoimmune syndrome and Sjögren’s syndrome. J Transl Med. 2015;13:173.
Article
PubMed
PubMed Central
Google Scholar
Anaya JM, Castiblanco J, Rojas-Villarraga A, Pineda-Tamayo R, Levy RA, Gómez-Puerta J, et al. The multiple autoimmune syndromes. A clue for the autoimmune tautology. Clin Rev Allergy Immunol. 2012;43:256–64.
Article
CAS
PubMed
Google Scholar
Yazdany J, Yelin EH, Panopalis P, Trupin L, Julian L, Katz PP. Validation of the systemic lupus erythematosus activity questionnaire in a large observational cohort. Arthritis Rheum. 2008;59:136–43.
Article
PubMed
PubMed Central
Google Scholar
Karlson EW, Daltroy LH, Rivest C, Ramsey-Goldman R, Wright EA, Partridge AJ, et al. Validation of a Systemic Lupus Activity Questionnaire (SLAQ) for population studies. Lupus. 2003;12:280–6.
Article
CAS
PubMed
Google Scholar
Romero-Diaz J, Isenberg D, Ramsey-Goldman R. Measures of adult systemic lupus erythematosus: updated version of British Isles Lupus Assessment Group (BILAG 2004), European Consensus Lupus Activity Measurements (ECLAM), Systemic Lupus Activity Measure, Revised (SLAM-R), Systemic Lupus Activity Questi. Arthritis Care Res (Hoboken). 2011;63(Suppl 1):S37–46.
Article
Google Scholar
Kardinaal AFM, van Erk MJ, Dutman AE, Stroeve JHM, van de Steeg E, Bijlsma S, et al. Quantifying phenotypic flexibility as the response to a high-fat challenge test in different states of metabolic health. FASEB J. 2015;29:4600–13.
Article
CAS
PubMed
Google Scholar
Willis R, Smikle M, DeCeulaer K, Romay-Penabad Z, Papalardo E, Jajoria P, et al. Clinical associations of proinflammatory cytokines, oxidative biomarkers and vitamin D levels in systemic lupus erythematosus. Lupus. 2017. https://doi.org/10.1177/0961203317706557.
Google Scholar
Lebart L, Morineau A, Piron M. Statistique exploratoire multidimensionnelle. Paris: Dunod; 1995.
Google Scholar
Severiche-Maury DM, Restrepo-Escobar M, Naranjo-González LA, Vanegas-García AL, Muñoz-Vahos CH, Carlos María G, Vásquez-Duque G. Ciento quince pacientes con lupus eritematoso sistemico: caracteristicas clínicas e inmunologicas. Rev Colomb Reumatol. 2014;1:183–92.
Google Scholar
To CH, Mok CC, Tang SSK, Ying SKY, Wong RWS, Lau CS. Prognostically distinct clinical patterns of systemic lupus erythematosus identified by cluster analysis. Lupus. 2009;18:1267–75.
Article
CAS
PubMed
Google Scholar
Poole BD, Schneider RI, Guthridge JM, Velte CA, Reichlin M, Harley JB, et al. Early targets of nuclear RNP humoral autoimmunity in human systemic lupus erythematosus. Arthritis Rheum. 2009;60:848–59.
Article
CAS
PubMed
PubMed Central
Google Scholar
Meilof JF, Veldhoven CH, Swaak AJ, Smeenk RJ. Production of anti-Ro/SS-A and anti-La/SS-B autoantibodies is closely coordinated in systemic lupus erythematosus and independent of anti-dsDNA production. J Autoimmun. 1997;10:67–75.
Article
CAS
PubMed
Google Scholar
Holloway L, Humphrey L, Heron L, Pilling C, Kitchen H, Højbjerre L, et al. Patient-reported outcome measures for systemic lupus erythematosus clinical trials: a review of content validity, face validity and psychometric performance. Health Qual Life Outcomes. 2014;12:116.
Article
PubMed
PubMed Central
Google Scholar
Reveille JD. Predictive value of autoantibodies for activity of systemic lupus erythematosus. Lupus. 2004;13:290–7.
Article
CAS
PubMed
Google Scholar
Baggiolini M, Loetscher P, Moser B. Interleukin-8 and the chemokine family. Int J Immunopharmacol. 1995;17:103–8.
Article
CAS
PubMed
Google Scholar
Eilertsen GØ, Nikolaisen C, Becker-Merok A, Nossent JC. Interleukin-6 promotes arthritis and joint deformation in patients with systemic lupus erythematosus. Lupus. 2011;20:607–13.
Article
CAS
PubMed
Google Scholar
Wu Y, Cai B, Zhang J, Shen B, Huang Z, Tan C, et al. IL-1β and IL-6 Are Highly Expressed in RF + IgE + Systemic Lupus Erythematous Subtype. J Immunol Res. 2017;2017:5096741.
PubMed
PubMed Central
Google Scholar
Vega-Ostertag M, Casper K, Swerlick R, Ferrara D, Harris EN, Pierangeli SS. Involvement of p38 MAPK in the up-regulation of tissue factor on endothelial cells by antiphospholipid antibodies. Arthritis Rheum. 2005;52:1545–54.
Article
CAS
PubMed
Google Scholar
Hsieh SC, Sun KH, Tsai CY, Tsai YY, Tsai ST, Huang DF, et al. Monoclonal anti-double stranded DNA antibody is a leucocyte-binding protein to up-regulate interleukin-8 gene expression and elicit apoptosis of normal human polymorphonuclear neutrophils. Rheumatology. 2001;40:851–8.
Article
CAS
PubMed
Google Scholar
Sun KH, Yu CL, Tang SJ, Sun GH. Monoclonal anti-double-stranded DNA autoantibody stimulates the expression and release of IL-1beta, IL-6, IL-8, IL-10 and TNF-alpha from normal human mononuclear cells involving in the lupus pathogenesis. Immunology. 2000;99:352–60.
Article
CAS
PubMed
PubMed Central
Google Scholar
Mehta HM, Malandra M, Corey SJ. G-CSF and GM-CSF in Neutropenia. J Immunol. 2015;195:1341–9.
Article
CAS
PubMed
PubMed Central
Google Scholar
Teng MWL, Bowman EP, McElwee JJ, Smyth MJ, Casanova JL, Cooper AM, et al. IL-12 and IL-23 cytokines: from discovery to targeted therapies for immune-mediated inflammatory diseases. Nat Med. 2015;21:719–29.
Article
CAS
PubMed
Google Scholar
Croxford AL, Kulig P, Becher B. IL-12-and IL-23 in health and disease. Cytokine Growth Factor Rev. 2014;25:415–21.
Article
CAS
PubMed
Google Scholar
Talaat RM, Mohamed SF, Bassyouni IH, Raouf AA. Th1/Th2/Th17/Treg cytokine imbalance in systemic lupus erythematosus (SLE) patients: correlation with disease activity. Cytokine. 2015;72:146–53.
Article
CAS
PubMed
Google Scholar
Leng RX, Pan HF, Chen GM, Wang C, Qin WZ, Chen LL, et al. IL-23: a promising therapeutic target for systemic lupus erythematosus. Arch Med Res. 2010;41:221–5.
Article
CAS
PubMed
Google Scholar
Rodero MP, Crow YJ. Type I interferon-mediated monogenic autoinflammation: the type I interferonopathies, a conceptual overview. J Exp Med. 2016;213:2527–38.
Article
CAS
PubMed
PubMed Central
Google Scholar
Khamashta M, Merrill JT, Werth VP, Furie R, Kalunian K, Illei GG, et al. Sifalimumab, an anti-interferon-α monoclonal antibody, in moderate to severe systemic lupus erythematosus: a randomised, double-blind, placebo-controlled study. Ann Rheum Dis. 2016;75:1909–16.
Article
PubMed
PubMed Central
Google Scholar
Furie R, Khamashta M, Merrill JT, Werth VP, Kalunian K, Brohawn P, et al. Anifrolumab, an anti-Interferon-α receptor monoclonal antibody, in moderate-to-severe systemic lupus erythematosus. Arthritis Rheumatol. 2017;69:376–86.
Article
CAS
PubMed
PubMed Central
Google Scholar
Gómez D, Correa PA, Gómez LM, Cadena J, Molina JF, Anaya J-M. Th1/Th2 cytokines in patients with systemic lupus erythematosus: is tumor necrosis factor alpha protective? Semin Arthritis Rheum. 2004;33:404–13.
Article
PubMed
Google Scholar
Cantaert T, Baeten D, Tak PP, van Baarsen LGM. Type I IFN and TNFα cross-regulation in immune-mediated inflammatory disease: basic concepts and clinical relevance. Arthritis Res Ther. 2010;12:219.
Article
PubMed
PubMed Central
Google Scholar
Beringer A, Noack M, Miossec P. IL-17 in chronic inflammation: from discovery to targeting. Trends Mol Med. 2016;22:230–41.
Article
CAS
PubMed
Google Scholar
Jordan SC, Choi J, Kim I, Wu G, Toyoda M, Shin B, et al. Interleukin-6, A Cytokine Critical to Mediation of Inflammation, Autoimmunity and Allograft Rejection: therapeutic Implications of IL-6 Receptor Blockade. Transplantation. 2017;101:32–44.
Article
CAS
PubMed
Google Scholar
Umare V, Pradhan V, Nadkar M, Rajadhyaksha A, Patwardhan M, Ghosh KK, et al. Effect of proinflammatory cytokines (IL-6, TNF-α, and IL-1β) on clinical manifestations in Indian SLE patients. Mediators Inflamm. 2014;2014:385297.
Article
PubMed
PubMed Central
Google Scholar
Cigni A, Pileri PV, Faedda R, Gallo P, Sini A, Satta AE, et al. Interleukin 1, interleukin 6, interleukin 10, and tumor necrosis factor α in active and quiescent systemic lupus erythematosus. J Investig Med. 2014;62:825–9.
Article
CAS
PubMed
Google Scholar
Kahlenberg JM, Kaplan MJ. The inflammasome and lupus: another innate immune mechanism contributing to disease pathogenesis? Curr Opin Rheumatol. 2014;26:475–81.
Article
CAS
PubMed
PubMed Central
Google Scholar
Humrich JY, Riemekasten G. Restoring regulation—IL-2 therapy in systemic lupus erythematosus. Expert Rev. Clin. Immunol. 2016;12:1153–60.
Article
CAS
PubMed
Google Scholar
Dai H, He F, Tsokos GC, Kyttaris VC. IL-23 Limits the Production of IL-2 and Promotes Autoimmunity in Lupus. J Immunol. 2017;199:903–10.
Article
CAS
PubMed
Google Scholar
Rojas-Zuleta WG, Vásquez G. Th9 lymphocytes: a recent history from IL-9 to its potential role in rheumatic diseases. Autoimmun Rev. 2016;15:649–55.
Article
CAS
PubMed
Google Scholar
Pollard KM, Cauvi DM, Toomey CB, Morris KV, Kono DH. Interferon-γ and systemic autoimmunity. Discov Med. 2013;16:123–31.
PubMed
PubMed Central
Google Scholar
Brito TNS, Vilar MJ, Almeida JB, Faria ALSB, Medeiros SDV, Medeiros MCC, et al. Measuring eosinophiluria, urinary eosinophil cationic protein and urinary interleukin-5 in patients with Lupus Nephritis. Allergy Asthma Clin Immunol. 2014;10:61.
Article
PubMed
PubMed Central
Google Scholar
Singh RR. IL-4 and many roads to lupuslike autoimmunity. Clin Immunol. 2003;108:73–9.
Article
CAS
PubMed
Google Scholar
Peng H, Wang W, Zhou M, Li R, Pan HF, Ye DQ. Role of interleukin-10 and interleukin-10 receptor in systemic lupus erythematosus. Clin Rheumatol. 2013;32:1255–66.
Article
PubMed
Google Scholar
Li D, Guo B, Wu H, Tan L, Chang C, Lu Q. Interleukin-17 in systemic lupus erythematosus: a comprehensive review. Autoimmunity. 2015;48:353–61.
Article
PubMed
Google Scholar
Catrina AI, Svensson CI, Malmström V, Schett G, Klareskog L. Mechanisms leading from systemic autoimmunity to joint-specific disease in rheumatoid arthritis. Nat Rev Rheumatol. 2017;13:79–86.
Article
CAS
PubMed
Google Scholar
Agmon-Levin N, Mosca M, Petri M, Shoenfeld Y. Systemic lupus erythematosus one disease or many? Autoimmun Rev. 2012;11:593–5.
Article
CAS
PubMed
Google Scholar
Anaya J, Duarte-Rey C, Sarmiento-Monroy JC, Bardey D, Castiblanco J, Rojas-Villarraga A. Personalized medicine. Closing the gap between knowledge and clinical practice. Autoimmun Rev. 2016;15:833–42.
Article
PubMed
Google Scholar
Chiche L, Jourde-Chiche N, Whalen E, Presnell S, Gersuk V, Dang K, et al. Modular transcriptional repertoire analyses of adults with systemic lupus erythematosus reveal distinct type I and type II interferon signatures. Arthritis Rheumatol. 2014;66:1583–95.
Article
CAS
PubMed
PubMed Central
Google Scholar
Teruel M, Chamberlain C, Alarcón-Riquelme ME. Omics studies: their use in diagnosis and reclassification of SLE and other systemic autoimmune diseases. Rheumatology. 2017;56:i78–87.
PubMed
Google Scholar
Churchman SM, Geiler J, Parmar R, Horner EA, Church LD, Emery P, et al. Multiplexing immunoassays for cytokine detection in the serum of patients with rheumatoid arthritis: lack of sensitivity and interference by rheumatoid factor. Clin Exp Rheumatol. 2012;30:534–42.
PubMed
Google Scholar
Mathian A, Hie M, Cohen-Aubart F, Amoura Z. Targeting interferons in systemic lupus erythematosus: current and future prospects. Drugs. 2015;75:835–46.
Article
CAS
PubMed
Google Scholar
Annapureddy N, Devilliers H, Jolly M. Patient-reported outcomes in lupus clinical trials with biologics. Lupus. 2016;25:1111–21.
Article
CAS
PubMed
Google Scholar