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Cellular Metabolism Therapy

Section Edited by Salvatore Nesci

Cellular Metabolism Therapy aims to promote the translation of basic research emerging from biochemistry, molecular medicine, physiology and biotechnology into cell metabolism in order to be exploited in clinical applications. 

Studies considered for publication will cover any aspect of translational metabolic research, including (but not limited to): genetic disorders and epigenetic diseases; metabolic derangements causing neurodegeneration; immunometabolism; stroke; cardiovascular diseases; tumours; stem cell bioenergetics; ageing; carbohydrate, lipid, and protein metabolism.


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  1. Human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) are seed cells that can be used for alternative treatment of myocardial damage. However, their immaturity limits their clinical applicatio...

    Authors: Huiwen Liu, Li Wang, Hao Xu, Bin Tan, Qin Yi, Hongrong Deng, Yunxia Chen, Bolin He, Jie Tian and Jing Zhu
    Citation: Journal of Translational Medicine 2023 21:581
    Content type: Research Published on:

  2. Benign prostatic hyperplasia (BPH) is a common disease in elderly men, mainly resulted from an imbalance between cell proliferation and death. Glutathione peroxidase 3 (GPX3) was one of the differentially expr...

    Authors: Yan Li, Yongying Zhou, Daoquan Liu, Zhen Wang, Jizhang Qiu, Junchao Zhang, Ping Chen, Guang Zeng, Yuming Guo, Xinghuan Wang, Michael E. DiSanto and Xinhua Zhang
    Citation: Journal of Translational Medicine 2023 21:575
    Content type: Research Published on:

  3. Rheumatoid arthritis (RA) is an autoimmune disease that exhibits a high degree of heterogeneity, marked by unpredictable disease flares and significant variations in the response to available treatments. The l...

    Authors: Qi Wang, Qi-Chao Gao, Qi-Chuan Wang, Li Wu, Qi Yu and Pei-Feng He
    Citation: Journal of Translational Medicine 2023 21:561
    Content type: Research Published on:

  4. Peripheral nerve injury can cause neuroinflammation and neuromodulation that lead to mitochondrial dysfunction and neuronal apoptosis in the dorsal root ganglion (DRG) and spinal cord, contributing to neuropat...

    Authors: Yaseen Awad-Igbaria, Nadine Ferreira, Ali Keadan, Reem Sakas, Doron Edelman, Alon Shamir, Jean Francous-Soustiel and Eilam Palzur
    Citation: Journal of Translational Medicine 2023 21:545
    Content type: Research Published on:

  5. Glioblastoma (GBM) is a brain tumor with the highest level of malignancy and the worst prognosis in the central nervous system. Mitochondrial metabolism plays a vital role in the occurrence and development of ...

    Authors: Tongxuan Guo, Changyong Wu, Lingni Zhou, Junhao Zhang, Wanzhou Wang, Yang Shen, Ludong Zhang, Mingshan Niu, Xu Zhang, Rutong Yu and Xuejiao Liu
    Citation: Journal of Translational Medicine 2023 21:532
    Content type: Research Published on:

  6. Colorectal cancer (CRC) can be classified into four molecular subtypes (CMS) among which CMS1 is associated with the best prognosis, while CMS4, the mesenchymal subtype, has the worst outcome. Although mitocho...

    Authors: Jean Bastin, Marine Sroussi, Ivan Nemazanyy, Pierre Laurent-Puig, Sophie Mouillet-Richard and Fatima Djouadi
    Citation: Journal of Translational Medicine 2023 21:522
    Content type: Research Published on:

  7. Mitochondria are the only organelles regulated by two genomes. The coordinated translation of nuclear DNA (nDNA) and mitochondrial DNA (mtDNA), which together co-encode the subunits of the oxidative phosphoryl...

    Authors: Jiaoyan Ma, Liankun Sun, Weinan Gao, Yang Li and Delu Dong
    Citation: Journal of Translational Medicine 2023 21:512
    Content type: Review Published on:

  8. Metabolic dysfunction-associated fatty liver disease (MAFLD) is among the most widespread metabolic disease globally, and its associated complications including insulin resistance and diabetes have become thre...

    Authors: Youwei Zheng, Shiting Wang, Jialiang Wu and Yong Wang
    Citation: Journal of Translational Medicine 2023 21:510
    Content type: Review Published on:

  9. Mitochondria play important roles in maintaining cellular homeostasis and skeletal muscle health, and damage to mitochondria can lead to a series of pathophysiological changes. Mitochondrial dysfunction can le...

    Authors: Xin Chen, Yanan Ji, Ruiqi Liu, Xucheng Zhu, Kexin Wang, Xiaoming Yang, Boya Liu, Zihui Gao, Yan Huang, Yuntian Shen, Hua Liu and Hualin Sun
    Citation: Journal of Translational Medicine 2023 21:503
    Content type: Review Published on:

  10. Diabetes is associated with an increased risk of cognitive decline and dementia. These diseases are linked with mitochondrial dysfunction, most likely as a consequence of excessive formation of mitochondria-as...

    Authors: Yanmin Chang, Cailin Wang, Jiahui Zhu, Siyi Zheng, Shangqi Sun, Yanqing Wu, Xingjun Jiang, Lulu Li, Rong Ma and Gang Li
    Citation: Journal of Translational Medicine 2023 21:494
    Content type: Research Published on:

  11. Lipid metabolism plays an important role in liver regeneration, but its regulation still requires further research. In this study, lipid metabolites involved in mouse liver regeneration at different time point...

    Authors: Xi Zhou, Guobin Huang, Lu Wang, Yuanyuan Zhao, Junbo Li, Dong Chen, Lai Wei, Zhishui Chen and Bo Yang
    Citation: Journal of Translational Medicine 2023 21:487
    Content type: Research Published on:

  12. Sepsis-associated encephalopathy (SAE) is characterized by diffuse brain dysfunction, long-term cognitive impairment, and increased morbidity and mortality. The current treatment for SAE is mainly symptomatic;...

    Authors: Yuqiang Liu, Han Yang, Nanbo Luo, Yifei Fu, Fang Qiu, Zhenglong Pan, Xiongjuan Li, Wenling Jian, Xinping Yang, Qingsheng Xue, Yan Luo, Buwei Yu and Zhiheng Liu
    Citation: Journal of Translational Medicine 2023 21:486
    Content type: Research Published on:

  13. Bone regeneration therapy is clinically important, and targeted regulation of endoplasmic reticulum (ER) stress is important in regenerative medicine. The processing of proteins in the ER controls cell fate. T...

    Authors: Tingyu Wu, Yaping Jiang, Weipeng Shi, Yingzhen Wang and Tao Li
    Citation: Journal of Translational Medicine 2023 21:480
    Content type: Review Published on:

  14. Interleukin-1 receptor antagonist (IL-1RA), a member of the IL-1 family, has diverse roles in cancer development. However, the role of IL-1RA in oral squamous cell carcinoma (OSCC), in particular the underlyin...

    Authors: Shyng-Shiou F. Yuan, Yun-Ming Wang, Leong-Perng Chan, Amos C. Hung, Hieu D. H. Nguyen, Yuk-Kwan Chen, Stephen Chu‐Sung Hu, Steven Lo and Yen-Yun Wang
    Citation: Journal of Translational Medicine 2023 21:473
    Content type: Research Published on:

  15. Cell pyroptosis has a strong proinflammatory effect, but it is unclear whether pyroptosis of liver macrophages exacerbates liver tissue damage during liver ischemia‒reperfusion (I/R) injury. Maresin1 (MaR1) ha...

    Authors: Tong Li, Houshuai Zeng, Wenjing Xian, Hongxing Cai, Jianbo Zhang, Shiji Zhou, Yingxue Yang, Min Luo and Peng Zhu
    Citation: Journal of Translational Medicine 2023 21:472
    Content type: Research Published on:

  16. Pulmonary arterial hypertension (PAH) is a highly prevalent cardiopulmonary disorder characterized by vascular remodeling and increased resistance in pulmonary artery. Mitochondrial coiled–coil–helix–coiled–co...

    Authors: Yu Wang, Zhenyu Zeng, Zhaoxiang Zeng, Guojun Chu and Xinghua Shan
    Citation: Journal of Translational Medicine 2023 21:464
    Content type: Research Published on:

  17. Alzheimer's disease (AD) is the most common neurodegenerative disease. Mitochondrial dysfunction and immune responses are important factors in the pathogenesis of AD, but their crosstalk in AD has not been stu...

    Authors: Yaodan Zhang, Yuyang Miao, Jin Tan, Fanglian Chen, Ping Lei and Qiang Zhang
    Citation: Journal of Translational Medicine 2023 21:458
    Content type: Research Published on:

  18. Osteoarthritis (OA), in which macrophage-driven synovitis is considered closely related to cartilage destruction and could occur at any stage, is an inflammatory arthritis. However, there are no effective targ...

    Authors: Zhen Zhang, Shujun Xie, Jin Qian, Fengqiang Gao, Wenjian Jin, Lingqiao Wang, Lili Yan, Hao Chen, Wangxiang Yao, Maoqiang Li, Xuepeng Wang and Liulong Zhu
    Citation: Journal of Translational Medicine 2023 21:452
    Content type: Research Published on:

  19. Endothelial cells (ECs) angiogenesis is the process of sprouting new vessels from the existing ones, playing critical roles in physiological and pathological processes such as wound healing, placentation, isch...

    Authors: Zhen Luo, Jianbo Yao, Zhe Wang and Jianxiong Xu
    Citation: Journal of Translational Medicine 2023 21:441
    Content type: Review Published on:

  20. Inflammation and immune dysfunction with classically activated macrophages(M1) infiltration are important mechanisms in the progression of atherosclerosis (AS). Dynamin-related protein 1 (DRP1)-dependent mitoc...

    Authors: Ze-da-zhong Su, Chun-qiu Li, Hua-wei Wang, Min-ming Zheng and Qing-wei Chen
    Citation: Journal of Translational Medicine 2023 21:427
    Content type: Research Published on:

  21. Acute-on-chronic liver failure (ACLF) is a severe syndrome with high short-term mortality, but the pathophysiology still remains largely unknown. Immune dysregulation and metabolic disorders contribute to the ...

    Authors: Bo Peng, Hao Li, Kai Liu, Pengpeng Zhang, Quan Zhuang, Junhui Li, Min Yang, Ke Cheng and Yingzi Ming
    Citation: Journal of Translational Medicine 2023 21:419
    Content type: Research Published on:

  22. The family with sequence similarity 20-member C (FAM20C) kinase, a Golgi casein kinase, which is responsible for phosphorylating the majority of the extracellular phosphoproteins within S-x-E/pS motifs, and is...

    Authors: Xinpeng Liu, Lili Jiang, Wenxuan Zhang, Jiahui Zhang, Xinrui Luan, Yuanbo Zhan, Tuo Wang, Junlong Da, Lixue Liu, Shujian Zhang, Yuyao Guo, Kai Zhang, Zhiping Wang, Nan Miao, Xiaohua Xie, Peihong Liu…
    Citation: Journal of Translational Medicine 2023 21:417
    Content type: Research Published on:

  23. Nucleus pulposus cell (NPC) death and progressive reduction play important roles in intervertebral disc degeneration (IVDD). As part of a damage-associated molecular pattern, mitochondrial DNA (mtDNA) can be r...

    Authors: Peng Lu, Huayong Zheng, Hao Meng, Chuan Liu, Lianhong Duan, Jianzheng Zhang, Zhicheng Zhang, Jie Gao, Yang Zhang and Tiansheng Sun
    Citation: Journal of Translational Medicine 2023 21:389
    Content type: Research Published on:

  24. Cardiovascular disease (CVD) is the leading cause of noncommunicable disease-related death worldwide, and effective therapeutic strategies against CVD are urgently needed. Mitochondria dysfunction involves in ...

    Authors: Mingchu Sun, Wenhua Jiang, Nan Mu, Zihui Zhang, Lu Yu and Heng Ma
    Citation: Journal of Translational Medicine 2023 21:347
    Content type: Review Published on:

  25. Malignant melanoma is one of the most common tumours and has the highest mortality rate of all types of skin cancers worldwide. Traditional and novel therapeutic approaches, including surgery, targeted therapy...

    Authors: Fei Du, Lu-han Yang, Jiao Liu, Jian Wang, Lianpeng Fan, Suwit Duangmano, Hao Liu, Minghua Liu, Jun Wang, Xiaolin Zhong, Zhuo Zhang and Fang Wang
    Citation: Journal of Translational Medicine 2023 21:345
    Content type: Review Published on:

  26. Interleukin-17A (IL-17A), a proinflammatory cytokine primarily secreted by Th17 cells, γδT cells and natural killer T (NKT) cells, performs essential roles in the microenvironment of certain inflammation-relat...

    Authors: Wen-Qing Feng, Yu-Chen Zhang, Zhuo-Qing Xu, Su-Yue Yu, Jian-ting Huo, Abudumaimaitijiang Tuersun, Min-Hua Zheng, Jing-Kun Zhao, Ya-Ping Zong and Ai-Guo Lu
    Citation: Journal of Translational Medicine 2023 21:335
    Content type: Research Published on:

  27. People with mitochondrial disease (MtD) are susceptible to metabolic decompensation and neurological symptom progression in response to an infection. Increasing evidence suggests that mitochondrial dysfunction...

    Authors: Emily B. Warren, Eliza M. Gordon-Lipkin, Foo Cheung, Jinguo Chen, Amrita Mukherjee, Richard Apps, John S. Tsang, Jillian Jetmore, Melissa L. Schlein, Shannon Kruk, Yuanjiu Lei, A. Phillip West and Peter J. McGuire
    Citation: Journal of Translational Medicine 2023 21:331
    Content type: Research Published on:

  28. Oral squamous cell carcinoma (OSCC) is one of the most prevalent and fatal oral cancers. Mitochondria-targeting therapies represent promising strategies against various cancers, but their applications in treat...

    Authors: Yafei Zhang, Bingqian Yang, Chengwei Tu, Yifan Ping, Shuhong Chen, Tong Wu, Zheyu Zhao, Yixin Mao, Zhan Yang, Zelin Cao, Jianmin Li, Kate Huang, Xi Ding, Gang Wu, Peng Zou, Zhennan Deng…
    Citation: Journal of Translational Medicine 2023 21:328
    Content type: Research Published on:

  29. Cervical cancer remains one of the most prevalent cancers worldwide. Accumulating evidence suggests that specificity protein 1 (Sp1) plays a pivotal role in tumour progression. The underlying role and mechanis...

    Authors: Xu Xu, Xiaona Wang, Qihui Chen, Aman Zheng, Donglu Li, Ziqi Meng, Xinran Li, Hanchen Cai, Wangzhi Li, Shiyuan Huang and Fan Wang
    Citation: Journal of Translational Medicine 2023 21:307
    Content type: Research Published on:

  30. Available literature documents that ischemic stroke can disrupt the morphology and function of mitochondria and that the latter in other disease models can be preserved by neuropilin-1 (NRP-1) via oxidative st...

    Authors: Ting Guo, Manli Chen, Ji Liu, Zengyu Wei, Jinjin Yuan, Wenwen Wu, Zhiyun Wu, Yongxing Lai, Zijun Zhao, Hongbin Chen and Nan Liu
    Citation: Journal of Translational Medicine 2023 21:297
    Content type: Research Published on:

  31. Immune-mediated rejection was the major cause of graft dysfunction. Although the advances in immunosuppressive agents have markedly reduced the incidence of T-cell-mediated rejection after transplantation. How...

    Authors: Yannan Zhang, Jiannan He, Zhe Yang, Haofeng Zheng, Haoxiang Deng, Zihuan Luo, Qipeng Sun and Qiquan Sun
    Citation: Journal of Translational Medicine 2023 21:295
    Content type: Research Published on:

  32. Recent evidence has shown significant roles of mitochondria-derived vesicles (MDVs) in mitochondrial quality control (MQC) system. Under mild stress condition, MDVs are formed to carry the malfunctioned mitoch...

    Authors: Sakdithep Chaiyarit and Visith Thongboonkerd
    Citation: Journal of Translational Medicine 2023 21:294
    Content type: Review Published on:

    The Correction to this article has been published in Journal of Translational Medicine 2023 21:460

  33. The Hypoxia inducible gene domain family member 2A (HIGD2A) protein is indispensable for the assembly of the mitochondrial respiratory supercomplex, which has been implicated in cell proliferation and cell sur...

    Authors: Kuiyuan Huang, Ziying Liu, Zhanglian Xie, Xiaoran Li, Haixing Zhang, Yu Chen, Yiran Wang, Zimo Lin, Chuanjiang Li, Hongyan Liu and Xiaoyong Zhang
    Citation: Journal of Translational Medicine 2023 21:253
    Content type: Research Published on:

  34. Lung adenocarcinoma (LUAD) is the most prevalent subtype of lung cancer with high morbidity and mortality rates. Due to the heterogeneity of LUAD, its characteristics remain poorly understood. Exploring the cl...

    Authors: Yichun Xu, Yong Yang, Yichao Wang, Jun Su, Tianlong Chan, Jiajing Zhou, Yi Gong, Ke Wang, Yifeng Gu, Congmeng Zhang, Guanjin Wu, Ling Bi, Xiong Qin and Junsong Han
    Citation: Journal of Translational Medicine 2023 21:250
    Content type: Research Published on:

    The Correction to this article has been published in Journal of Translational Medicine 2023 21:268

  35. Substantial evidence suggests that immunoproteasome is implicated in the various neurological diseases such as stroke, multiple sclerosis and neurodegenerative diseases. However, whether the immunoproteasome i...

    Authors: Xingyong Chen, Yanguang Mao, Yueting Guo, Dongyun Xiao, Zejing Lin, Yiyi Huang, Ying Chun Liu, Xu Zhang and Yinzhou Wang
    Citation: Journal of Translational Medicine 2023 21:226
    Content type: Research Published on:

  36. Both the crystalline and soluble forms of cholesterol increase macrophage secretion of interleukin 1β (IL-1β), aggravating the inflammatory response in atherosclerosis (AS). However, the link between cholester...

    Authors: Huanzhi Zhang, Ni Xia, Tingting Tang, Shaofang Nie, Lingfeng Zha, Min Zhang, Bingjie Lv, Yuzhi Lu, Jiao Jiao, Jingyong Li and Xiang Cheng
    Citation: Journal of Translational Medicine 2023 21:224
    Content type: Research Published on:

  37. Diabetic cardiomyopathy (DCM) has been considered as a major threat to health in individuals with diabetes. GrpE-like 2 (Grpel2), a nucleotide exchange factor, has been shown to regulate mitochondrial import p...

    Authors: Rongjin Yang, Xiaomeng Zhang, Yunyun Zhang, Yingfan Wang, Man Li, Yuancui Meng, Jianbang Wang, Xue Wen, Jun Yu and Pan Chang
    Citation: Journal of Translational Medicine 2023 21:200
    Content type: Research Published on:

  38. The incidence and mortality of gastric cancer ranks fifth and fourth worldwide among all malignancies, respectively. Accumulating evidences have revealed the close relationship between mitochondrial dysfunctio...

    Authors: Jingjia Chang, Hao Wu, Jin Wu, Ming Liu, Wentao Zhang, Yanfen Hu, Xintong Zhang, Jing Xu, Li Li, Pengfei Yu and Jianjun Zhu
    Citation: Journal of Translational Medicine 2023 21:191
    Content type: Research Published on:

  39. The inner membrane mitochondrial protein (IMMT) is a central unit of the mitochondrial contact site and cristae organizing system (MICOS). While researchers continue to demonstrate the physiological function o...

    Authors: Hung-Yu Lin, Hsing-Ju Wu and Pei-Yi Chu
    Citation: Journal of Translational Medicine 2023 21:189
    Content type: Research Published on:

  40. To explore the association between translocase of the inner mitochondrial membrane 13 (Timm13) and liver fibrosis.

    Authors: Xiaomin Liao, Xianxian Ruan, Xianbin Wu, Zhejun Deng, Shanyu Qin and Haixing Jiang
    Citation: Journal of Translational Medicine 2023 21:188
    Content type: Research Published on:

  41. Necroptosis of macrophages is a necessary element in reinforcing intrapulmonary inflammation during acute lung injury (ALI). However, the molecular mechanism that sparks macrophage necroptosis is still unclear...

    Authors: Wen-Jing Zhong, Jun Zhang, Jia-Xi Duan, Chen-Yu Zhang, Sheng-Chao Ma, Yu-Sheng Li, Nan-Shi-Yu Yang, Hui-Hui Yang, Jian-Bing Xiong, Cha-Xiang Guan, Zhi-Xing Jiang, Zhi-Jian You and Yong Zhou
    Citation: Journal of Translational Medicine 2023 21:179
    Content type: Research Published on:

  42. Mitochondria represent a major source of reactive oxygen species (ROS) in cells, and the direct increase in ROS content is the primary cause of oxidative stress, which plays an important role in tumor prolifer...

    Authors: Shiao Tong, Minqi Xia, Yang Xu, Qian Sun, Liguo Ye, Fanen Yuan, Yixuan Wang, Jiayang Cai, Zhang Ye and Daofeng Tian
    Citation: Journal of Translational Medicine 2023 21:136
    Content type: Research Published on:

  43. The incidence and mortality rate of gastrointestinal cancers are high worldwide. Increasing studies have illustrated that the occurrence, progression, metastasis and prognosis of cancers are intimately linked ...

    Authors: Weili Liu, Yuan Gao, Hua Li, Xinxing Wang, Min Jin, Zhiqiang Shen, Dong Yang, Xuelian Zhang, Zilin Wei, Zhaoli Chen and Junwen Li
    Citation: Journal of Translational Medicine 2023 21:107
    Content type: Research Published on:

  44. Diabetic cardiomyopathy (DCM) is one of the common cardiovascular complications of diabetes and a leading cause of death in diabetic patients. Mitochondrial metabolism and immune-inflammation are key for DCM p...

    Authors: Cheng Peng, Yanxiu Zhang, Xueyan Lang and Yao Zhang
    Citation: Journal of Translational Medicine 2023 21:66
    Content type: Research Published on:

  45. Although β-catenin signaling cascade is frequently altered in human cancers, targeting this pathway has not been approved for cancer treatment.

    Authors: Yuting Wu, Shuhui Yang, Luyang Han, Kezhuo Shang, Baohui Zhang, Xiaochen Gai, Weiwei Deng, Fangming Liu and Hongbing Zhang
    Citation: Journal of Translational Medicine 2023 21:50
    Content type: Research Published on:

  46. MOTS-c is a peptide encoded by the short open reading frame of the mitochondrial 12S rRNA gene. It is significantly expressed in response to stress or exercise and translocated to the nucleus, where it regulat...

    Authors: Wei Wan, Lieliang Zhang, Yue Lin, Xiuqing Rao, Xifeng Wang, Fuzhou Hua and Jun Ying
    Citation: Journal of Translational Medicine 2023 21:36
    Content type: Review Published on:

  47. The disruption of blood-brain barrier (BBB), predominantly made up by brain microvascular endothelial cells (BMECs), is one of the characteristics of Alzheimer’s disease (AD). Thus, improving BMEC function may...

    Authors: Can Wan, Xiao-Qi Liu, Mei Chen, Hui-Han Ma, Guang-Liang Wu, Li-Jun Qiao, Ye-Feng Cai and Shi-Jie Zhang
    Citation: Journal of Translational Medicine 2023 21:34
    Content type: Research Published on:

  48. Mitochondria determine the physiological status of most eukaryotes. Mitochondrial dynamics plays an important role in maintaining mitochondrial homeostasis, and the disorder in mitochondrial dynamics could aff...

    Authors: Ao-ran Liu, Zhi Lv, Zi-wei Yan, Xiao-yang Wu, Li-rong Yan, Li-ping Sun, Yuan Yuan and Qian Xu
    Citation: Journal of Translational Medicine 2023 21:27
    Content type: Review Published on:

  49. Myocardial infarction (MI) has recently accounted for more than one-third of global mortality. Multiple molecular pathological pathways, such as oxidative stress, inflammation, and mitochondrial dysfunction, h...

    Authors: Chanon Piamsiri, Chayodom Maneechote, Kewarin Jinawong, Busarin Arunsak, Titikorn Chunchai, Wichwara Nawara, Siriporn C Chattipakorn and Nipon Chattipakorn
    Citation: Journal of Translational Medicine 2023 21:16
    Content type: Research Published on:

  50. Myeloid-derived suppressor cells (MDSCs), which are immature heterogeneous bone marrow cells, have been described as potent immune regulators in human and murine cancer models. The distribution of MDSCs varies...

    Authors: Xiaoli Lou, Deyong Gao, Liyuan Yang, Yue Wang and Yanqiang Hou
    Citation: Journal of Translational Medicine 2023 21:1
    Content type: Review Published on:

Journal of Translational Medicine

ISSN: 1479-5876

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