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Translational Imaging

Section edited by Ravinder Reddy and Mohammed Haris

The Translational Imaging section provides a platform for rapid dissemination of the advances in medical imaging research emphasizing clinical translation. The topics covered in this section will include methodological innovations in early diagnoses of human diseases and monitoring of therapeutic responses from all the major imaging modalities (MRI, PET, US etc.,). Articles considered for publication include studies in human subjects, pre-clinical models and ex vivo systems dealing with imaging of human pathophysiologies.

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  1. Myopic maculopathy (MM) is the most serious and irreversible complication of pathologic myopia, which is a major cause of visual impairment and blindness. Clinic proposed limited number of factors related to M...

    Authors: Yuchen Du, Qiuying Chen, Ying Fan, Jianfeng Zhu, Jiangnan He, Haidong Zou, Dazhen Sun, Bowen Xin, David Feng, Michael Fulham, Xiuying Wang, Lisheng Wang and Xun Xu
    Citation: Journal of Translational Medicine 2021 19:167
    Content type: Research Published on:

    The Correction to this article has been published in Journal of Translational Medicine 2021 19:203

  2. Limited data was available for rapid and accurate detection of COVID-19 using CT-based machine learning model. This study aimed to investigate the value of chest CT radiomics for diagnosing COVID-19 pneumonia ...

    Authors: Huanhuan Liu, Hua Ren, Zengbin Wu, He Xu, Shuhai Zhang, Jinning Li, Liang Hou, Runmin Chi, Hui Zheng, Yanhong Chen, Shaofeng Duan, Huimin Li, Zongyu Xie and Dengbin Wang
    Citation: Journal of Translational Medicine 2021 19:29
    Content type: Research Published on:

  3. Diffuse intrinsic pontine glioma (DIPG) is the most common brainstem cancer in childhood. This rapidly progressing brainstem glioma holds a very dismal prognosis with median survival of less than 1 year. Despi...

    Authors: Lincy Thomas, Nataliya Smith, Debra Saunders, Michelle Zalles, Rafal Gulej, Megan Lerner, Kar-Ming Fung, Angel M. Carcaboso and Rheal A. Towner
    Citation: Journal of Translational Medicine 2020 18:424
    Content type: Research Published on:

  4. Since the first case of a coronavirus disease 2019 (COVID-19) infection pneumonia was detected in Wuhan, China, a series of confirmed cases of the COVID-19 were found in Southwest China. The aim of this study ...

    Authors: Xiaoming Li, Wenbing Zeng, Xiang Li, Haonan Chen, Linping Shi, Xinghui Li, Hongnian Xiang, Yang Cao, Hui Chen, Chen Liu and Jian Wang
    Citation: Journal of Translational Medicine 2020 18:154
    Content type: Research Published on:

  6. Lupus nephritis is one of the most common and severe complications of systemic lupus erythematosus, of which poor prognosis is indicated by aggravated renal hypoxia and tubulointerstitial fibrosis. Cell adhesi...

    Authors: Liwen Zhang, Sheng Chen, Yan Liu, Xueqin Xu, Qianying Zhang, Shuxin Shao, Weiming Wang and Xiao Li
    Citation: Journal of Translational Medicine 2020 18:116
    Content type: Research Published on:

  7. There is a lack of well-established clinical tools for predicting dendritic cell (DC) vaccination response of pancreatic ductal adenocarcinoma (PDAC). DC vaccine treatment efficiency was demonstrated using his...

    Authors: Aydin Eresen, Jia Yang, Junjie Shangguan, Yu Li, Su Hu, Chong Sun, Yury Velichko, Vahid Yaghmai, Al B. Benson III and Zhuoli Zhang
    Citation: Journal of Translational Medicine 2020 18:61
    Content type: Research Published on:

  8. The temporomandibular joint (TMJ) is well innervated by braches of the trigeminal nerve. The temporomandibular joint disorders (TMD) can cause neural-inflammation in the peripheral nervous system (PNS) at the ...

    Authors: Andre Barkhordarian, Gary Demerjian and Francesco Chiappelli
    Citation: Journal of Translational Medicine 2020 18:22
    Content type: Research Published on:

  9. Spontaneously metastatic xenograft models of cancer are infrequent and the few that exist are resource intensive. In xenografts, caliper measurements can be used to determine primary tumor burden and response ...

    Authors: James L. Tatum, Joseph D. Kalen, Paula M. Jacobs, Lilia V. Ileva, Lisa A. Riffle, Melinda G. Hollingshead and James H. Doroshow
    Citation: Journal of Translational Medicine 2019 17:425
    Content type: Methodology Published on:

  10. Secondary and retrospective use of hospital-hosted clinical data provides a time- and cost-efficient alternative to prospective clinical trials for biomarker development. This study aims to create a retrospect...

    Authors: Rebecca J. Weiss, Sara V. Bates, Ya’nan Song, Yue Zhang, Emily M. Herzberg, Yih-Chieh Chen, Maryann Gong, Isabel Chien, Lily Zhang, Shawn N. Murphy, Randy L. Gollub, P. Ellen Grant and Yangming Ou
    Citation: Journal of Translational Medicine 2019 17:385
    Content type: Protocol Published on:

  11. To evaluate the imaging biomarkers of human epidermal growth factor receptor 2 (HER2) positive breast cancer in comparison to other molecular subtypes and to determine the feasibility of identifying hormone re...

    Authors: Chao You, Jianwei Li, Wenxiang Zhi, Yanqiong Chen, Wentao Yang, Yajia Gu and Weijun Peng
    Citation: Journal of Translational Medicine 2019 17:182
    Content type: Research Published on:

  12. Gene transfer to malignant sites using human adenoviruses (hAds) has been limited because of their immunogenic nature and host specificity. Murine cells often lack some of the receptors needed for hAds attachm...

    Authors: Flavia De Carlo, Litty Thomas, Bell Brooke, Elliot T. Varney, Rounak Nande, Olivia Boskovic, Gailen D. Marshall, Pier Paolo Claudio and Candace M. Howard
    Citation: Journal of Translational Medicine 2019 17:19
    Content type: Research Published on:

  13. Breast cancer surgeons struggle with differentiating healthy tissue from cancer at the resection margin during surgery. We report on the feasibility of using diffuse reflectance spectroscopy (DRS) for real-tim...

    Authors: Lisanne L. de Boer, Torre M. Bydlon, Frederieke van Duijnhoven, Marie-Jeanne T. F. D. Vranken Peeters, Claudette E. Loo, Gonneke A. O. Winter-Warnars, Joyce Sanders, Henricus J. C. M. Sterenborg, Benno H. W. Hendriks and Theo J. M. Ruers
    Citation: Journal of Translational Medicine 2018 16:367
    Content type: Research Published on:

  15. The human epidermal growth factor receptor 2 (HER2) involved proliferation, angiogenesis, and reduced apoptosis in gastric cancer (GC), which is a common target for tumor therapy. HER2 is usually overexpressed...

    Authors: Siao-Syun Guan, Cheng-Tien Wu, Chen-Yuan Chiu, Tsai-Yueh Luo, Jeng-Yih Wu, Tse-Zung Liao and Shing-Hwa Liu
    Citation: Journal of Translational Medicine 2018 16:168
    Content type: Research Published on:

  16. Surgical resection remains the mainstay of curative treatment for intrahepatic cholangiocarcinoma (ICC). Prognosis after surgery is unsatisfactory despite improvements in treatment and post-operative clinical ...

    Authors: Yoshinobu Ikeno, Satoru Seo, Keiko Iwaisako, Tomoaki Yoh, Yuji Nakamoto, Hiroaki Fuji, Kojiro Taura, Hideaki Okajima, Toshimi Kaido, Shimon Sakaguchi and Shinji Uemoto
    Citation: Journal of Translational Medicine 2018 16:95
    Content type: Research Published on:

  17. Magnetic resonance is a major preclinical and clinical imaging modality ideally suited for longitudinal studies, e.g. in pharmacological developments. The lack of a proven platform that maintains an identical ...

    Authors: Jörg Felder, A. Avdo Celik, Chang-Hoon Choi, Stefan Schwan and N. Jon Shah
    Citation: Journal of Translational Medicine 2017 15:264
    Content type: Methodology Published on:

  18. Systemic amyloidoses comprise diseases characterized by the deposition of proteinaceous material known as amyloid. Currently, without performing multiple biopsies, there is no way to ascertain the extent of am...

    Authors: Emily B. Martin, Angela Williams, Tina Richey, Craig Wooliver, Alan Stuckey, James S. Foster, Stephen J. Kennel and Jonathan S. Wall
    Citation: Journal of Translational Medicine 2017 15:247
    Content type: Research Published on:

  19. Dynamic-contrast-enhanced (DCE) MRI data acquired using gradient echo based sequences is affected by errors in flip angle (FA) due to transmit B1 inhomogeneity (B1inh). The purpose of the study was to evaluate th...

    Authors: Anirban Sengupta, Rakesh Kumar Gupta and Anup Singh
    Citation: Journal of Translational Medicine 2017 15:242
    Content type: Research Published on:

  20. Asthma is a multifactorial disease for which a variety of mouse models have been developed. A major drawback of these models is represented by the transient nature of the airway pathology peaking 24–72 h after...

    Authors: Fabio Stellari, Angelo Sala, Francesca Ruscitti, Chiara Carnini, Prisco Mirandola, Marco Vitale, Maurizio Civelli and Gino Villetti
    Citation: Journal of Translational Medicine 2015 13:336
    Content type: Research Published on:

  21. Acute-on-chronic liver failure (ACLF) is a form of liver disease with high short-term mortality. ACLF offers considerable potential to affect the cortical areas by significant tissue injury due to loss of neur...

    Authors: Santosh K. Yadav, Rakesh K. Gupta, Vivek A. Saraswat, Murali Rangan, Michael A. Thomas, Sergio Rutella, Silvio Danese, Ena Wang, Francesco M. Marincola and Mohammad Haris
    Citation: Journal of Translational Medicine 2015 13:322
    Content type: Research Published on:

  22. A real-time objective evaluation for the extent of liver steatosis during liver transplantation is currently not available. Diffuse reflectance spectroscopy (DRS) rapidly and accurately assesses the extent of...

    Authors: Andrie C. Westerkamp, Vishnu V. Pully, Golnar Karimian, Fernanda Bomfati, Zwanida J. Veldhuis, Janneke Wiersema-Buist, Benno H. W. Hendriks, Ton Lisman and Robert J. Porte
    Citation: Journal of Translational Medicine 2015 13:309
    Content type: Research Published on:

  23. Liver fibrosis is a public health problem worldwide. There is a need of noninvasive imaging based methods for better diagnosis of this disease. In the current study, we aim to evaluate the potential of T1ρ MRI...

    Authors: Anup Singh, Damodar Reddy, Mohammad Haris, Kejia Cai, K. Rajender Reddy, Hari Hariharan and Ravinder Reddy
    Citation: Journal of Translational Medicine 2015 13:292
    Content type: Research Published on:

  24. To acquire the most meaningful understanding of human arthritis, it is essential to select the disease model and methodology translatable to human conditions. The primary objective of this study was to evaluat...

    Authors: Cedo M. Bagi, David E. Zakur, Edwin Berryman, Catharine J. Andresen and Dean Wilkie
    Citation: Journal of Translational Medicine 2015 13:276
    Content type: Methodology Published on:

  25. Chronic inflammation of the airways is a central component in lung diseases and is frequently associated with bacterial infections. Monitoring the pro-inflammatory capability of bacterial virulence factors in ...

    Authors: Fabio Stellari, Gabriella Bergamini, Angela Sandri, Gaetano Donofrio, Claudio Sorio, Francesca Ruscitti, Gino Villetti, Barouk M Assael, Paola Melotti and Maria M Lleo
    Citation: Journal of Translational Medicine 2015 13:251
    Content type: Research Published on:
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Journal of Translational Medicine

ISSN: 1479-5876

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