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Nutrition & Metabolism

Section edited by Laura Soldati

This section aims to provide a platform for the interaction and mutual validation between basic and applied research in the field of nutrition. In the area of Translational Medicine, we believe that the field ought to be taken into greater account in order to generate advanced applications for diagnosis and therapy and, at the same time, to develop new instruments of investigation.

Studies on all aspects of nutrition and metabolism with applications in medicine and biotechnology will be considered for publication. The section not only welcomes contributions that employ traditional clinical, metabolic and epidemiologic methods, but is also interested in molecular and cell biology applied to human and animal nutrition.

Featured articles

Hericium erinaceus mycelium and its isolated erinacine A protection from MPTP-induced neurotoxicity through the ER stress, triggering an apoptosis cascade
Hsing-Chun Kuo, et al

Obesity and colorectal cancer: molecular features of adipose tissue
Javier Martinez-Useros and Jesus Garcia-Foncillas



Role of a polyphenol-enriched preparation on chemoprevention of mammary carcinoma through cancer stem cells and inflammatory pathways modulation
Tri Vuong, et al

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  1. Several abdominal obesity indices including waist circumference (WC), waist–hip ratio (WHR), visceral adiposity index (VAI), lipid accumulation product (LAP), and Chinese visceral adiposity index (CVAI) were c...

    Authors: Li Liu, Jie Peng, Dejin Zang, Yerui Zhang, Zhenguo Wu, Chunfei Song, Sha Chen, Dachuan Guo, Fanghong Lu, Tengfei Zheng and Jianmin Yang
    Citation: Journal of Translational Medicine 2024 22:855
    Content type: Research Published on:

  2. The underlying medical conditions and gut dysbiosis is known to influence COVID-19 severity in high-risk patients. The current review proposed the optimal usage of nutraceuticals & pharmacological intervention...

    Authors: Anju Kaushal
    Citation: Journal of Translational Medicine 2024 22:847
    Content type: Review Published on:

  4. The Mediterranean Diet (MD) has been recognized for its benefits for human health and sustainability for the planet, but it has considered not easy to reproduce in other populations. The United Nations Educati...

    Authors: Carlotta Franchi, Francesca Orsini, Federica Cantelli, Ilaria Ardoino, Prisco Piscitelli, Shana Shaji, Tao Ran, Nicholas Ainslie, Chiara Graziadio, Claudia Vetrani and Annamaria Colao
    Citation: Journal of Translational Medicine 2024 22:806
    Content type: Research Published on:

  5. Obesity is a serious global illness that is frequently associated with metabolic syndrome. Adipocytes are the typical cells of adipose organ, which is composed of at least two different tissues, white and brow...

    Authors: Tonia Luca, Salvatore Pezzino, Stefano Puleo and Sergio Castorina
    Citation: Journal of Translational Medicine 2024 22:764
    Content type: Review Published on:

  6. Inspiratory muscle fatigue has been shown to have effects on limbs blood flow and physical performance. This study aimed to evaluate the influence of an inspiratory muscle fatigue protocol on respiratory muscl...

    Authors: Arturo Ladriñán-Maestro, Jorge Sánchez-Infante, Daniel Martín-Vera and Alberto Sánchez-Sierra
    Citation: Journal of Translational Medicine 2024 22:732
    Content type: Research Published on:

  8. The Mediterranean diet (MD), known to prevent obesity, overweight and the related non communicable diseases (NCD), is based on typical dishes, foods and on a common cultural milieu. Although MD is the basis of...

    Authors: Ester Luconi, Martina Tosi, Patrizia Boracchi, Ilaria Colonna, Emilia Rappocciolo, Anita Ferraretto and Erna C. Lorenzini
    Citation: Journal of Translational Medicine 2024 22:703
    Content type: Research Published on:

  9. Aldehyde dehydrogenase 2 (ALDH2) is critical for alcohol metabolism by converting acetaldehyde to acetic acid. In East Asian descendants, an inactive genetic variant in ALDH2, rs671, triggers an alcohol flushing ...

    Authors: Freeborn Rwere, Joseph R. White, Rafaela C. R. Hell, Xuan Yu, Xiaocong Zeng, Leslie McNeil, Kevin N. Zhou, Martin S. Angst, Che-Hong Chen, Daria Mochly-Rosen and Eric R. Gross
    Citation: Journal of Translational Medicine 2024 22:697
    Content type: Research Published on:

  10. Effects of preoperative drinks on muscle metabolism are unclear despite general recommendations. The aim of the present study was therefore to compare metabolic effects of a preoperative oral nutrition drink, ...

    Authors: Britt-Marie Iresjö, Ulrika Smedh, Cecilia Engström, Jan Persson, Christian Mårtensson and Kent Lundholm
    Citation: Journal of Translational Medicine 2024 22:675
    Content type: Research Published on:

  11. Lung cancer is the deadliest cancer type worldwide with ~ 1.8 million deaths per-year. Smoking accounts for ~ 85% of all cases, with a described joint effect with unhealthy diet in lung cancer risk increase. P...

    Authors: Roberto Cuttano, Francesco Mazzarelli, Kuku Miriam Afanga, Fabrizio Bianchi and Elisa Dama
    Citation: Journal of Translational Medicine 2024 22:632
    Content type: Review Published on:

  12. Magnesium is a micronutrient and an intracellular cation responsible for different biochemical reactions involved in energy production and storage, control of neuronal and vasomotor activity, cardiac excitabil...

    Authors: Maria Grazia Tarsitano, Federico Quinzi, Katia Folino, Francesca Greco, Francesco Pio Oranges, Claudia Cerulli and Gian Pietro Emerenziani
    Citation: Journal of Translational Medicine 2024 22:629
    Content type: Review Published on:

  13. Obesity is a worldwide epidemic characterized by adipose tissue (AT) inflammation. AT is also a source of extracellular vesicles (EVs) that have recently been implicated in disorders related to metabolic syndr...

    Authors: Johanna Matilainen, Viivi Berg, Maija Vaittinen, Ulla Impola, Anne-Mari Mustonen, Ville Männistö, Marjo Malinen, Veera Luukkonen, Natalia Rosso, Tanja Turunen, Pirjo Käkelä, Silvia Palmisano, Uma Thanigai Arasu, Sanna P. Sihvo, Niina Aaltonen, Kai Härkönen…
    Citation: Journal of Translational Medicine 2024 22:623
    Content type: Research Published on:

  14. Carbohydrate antigen 125 (CA125) is a proteolytic fragment of MUC-16 that is increased in heart failure (HF) and associated with inflammation, fluid overload, and worse adverse events. Our main objective was t...

    Authors: Sonia Eiras, Rafael de la Espriella, Xiaoran Fu, Diego Iglesias-Álvarez, Rumeysa Basdas, J. R. Núñez-Caamaño, J. M. Martínez-Cereijo, L. Reija, A. L. Fernández, David Sánchez-López, Gema Miñana, Julio Núñez and José R. González-Juanatey
    Citation: Journal of Translational Medicine 2024 22:619
    Content type: Research Published on:

  15. Fundamentally defined by an imbalance in energy consumption and energy expenditure, obesity is a significant risk factor of several musculoskeletal conditions including osteoarthritis (OA). High-fat diets and ...

    Authors: Animesh Acharjee, Susanne N. Wijesinghe, Dominic Russ, Georgios Gkoutos and Simon W. Jones
    Citation: Journal of Translational Medicine 2024 22:592
    Content type: Research Published on:

  16. Metabolic dysfunction-associated steatotic liver disease (MASLD) has gained attention owing to its severe complications. This study aimed to explore the interaction between Mediterranean-diet (MD) adherence, g...

    Authors: Yu-Jin Kwon, Ja-Eun Choi, Kyung-Won Hong and Ji-Won Lee
    Citation: Journal of Translational Medicine 2024 22:591
    Content type: Research Published on:

  17. The challenge of addressing obesity persists in healthcare, necessitating nuanced approaches and personalized strategies. This study aims to evaluate the effects of diverse therapeutic interventions on anthrop...

    Authors: Keyvan Khorrami Chokami, Amir Khorrami Chokami, Giuseppe Cammarata, Grazia Piras, Manuela Albertelli, Federico Gatto, Lara Vera, Diego Ferone and Mara Boschetti
    Citation: Journal of Translational Medicine 2024 22:536
    Content type: Research Published on:

  18. Dizziness and vertigo rank among the top 10 reasons for emergency and clinical referrals to neurologists. Chronic dizziness and imbalance not only reduce quality of life, but also increase mortality. While the...

    Authors: Seong-Hae Jeong, Eun Ji Kim, Eunjin Kwon, Ji-Soo Kim and Sukyoung Jung
    Citation: Journal of Translational Medicine 2024 22:522
    Content type: Research Published on:

  19. The appropriate use of predictive equations in estimating body composition through bioelectrical impedance analysis (BIA) depends on the device used and the subject’s age, geographical ancestry, healthy status...

    Authors: Francesco Campa, Giuseppe Coratella, Giuseppe Cerullo, Zeasseska Noriega, Rubén Francisco, Davide Charrier, Alfredo Irurtia, Henry Lukaski, Analiza Mónica Silva and Antonio Paoli
    Citation: Journal of Translational Medicine 2024 22:515
    Content type: Review Published on:

  20. Substantial evidence embraced the nutrition competence of the Mediterranean diet (MD) as a healthy model for decreasing the risk of chronic diseases and increasing longevity, with the bonus of ensuring environ...

    Authors: Mona Hashim, Hadia Radwan, Leila Cheikh Ismail, MoezAllslam Ezzat Faris, Maysm N Mohamad, Sheima T. Saleh, Bisan Sweid, Raghad Naser, Rahaf Hijaz, Rania Altaher, Eman Rashed, Eman Turki and Mahra Al Kitbi
    Citation: Journal of Translational Medicine 2024 22:513
    Content type: Research Published on:

  22. The pathophysiology of toxico-nutritional optic neuropathies remains debated, with no clear understanding of the respective roles played by the direct alcohol toxicity, smoking and the often associated vitamin...

    Authors: Camille Delibes, Marc Ferré, Marine Rozet, Valérie Desquiret-Dumas, Alexis Descatha, Bénédicte Gohier, Philippe Gohier, Patrizia Amati-Bonneau, Dan Milea and Pascal Reynier
    Citation: Journal of Translational Medicine 2024 22:495
    Content type: Research Published on:

  23. The Mediterranean Diet (MD) has garnered increasing attention for its potential protective effects against gastric cancer (GC). The MD’s rich content of antioxidants, polyphenols, and other bioactive compounds...

    Authors: Claudia Reytor-González, Ana Karina Zambrano, Martha Montalvan, Evelyn Frias-Toral, Alison Simancas-Racines and Daniel Simancas-Racines
    Citation: Journal of Translational Medicine 2024 22:483
    Content type: Review Published on:

  24. The measurement of the skin carotenoids using the Veggie Meter® has emerged as a rapid objective method for assessing fruit and vegetable intake, highly recommended by the Mediterranean Diet (MD), which repres...

    Authors: Giuseppina Augimeri, Manuel Soto, Fabrizio Ceraudo, Giovanna Caparello, Melisa Villegas Figueroa, Mirko Cesario, Lorenzo S. Caputi, Berniza Calderón and Daniela Bonofiglio
    Citation: Journal of Translational Medicine 2024 22:424
    Content type: Research Published on:

  25. The Mediterranean diet (MedDiet) is a widely studied dietary pattern reflecting the culinary traditions of Mediterranean regions. High adherence to MedDiet correlates with reduced blood pressure and lower card...

    Authors: Ana Karina Zambrano, Santiago Cadena-Ullauri, Viviana A. Ruiz-Pozo, Rafael Tamayo-Trujillo, Elius Paz-Cruz, Patricia Guevara-Ramírez, Evelyn Frias-Toral and Daniel Simancas-Racines
    Citation: Journal of Translational Medicine 2024 22:417
    Content type: Review Published on:

  27. Quinic acid (QA) and its derivatives have good lipid-lowering and hepatoprotective functions, but their role in atherosclerosis remains unknown. This study attempted to investigate the mechanism of QA on ather...

    Authors: Qiao Jin, Chiyuan Zhang, Ran Chen, Luping Jiang, Hongli Li, Pengcui Wu and Liang Li
    Citation: Journal of Translational Medicine 2024 22:352
    Content type: Research Published on:

  28. The COVID-19 pandemic caused societal disruption in the United States and most of the world, affecting many aspects of life, including healthcare and health-related behaviors such as diet, food security, and p...

    Authors: Giovanna Muscogiuri, Lindsay Kohler, Oscar Parra, Lisa Soltani, Douglas Spegman, Dawn Coletta and Lawrence J. Mandarino
    Citation: Journal of Translational Medicine 2024 22:342
    Content type: Research Published on:

  29. Acne, a chronic inflammatory disease impacting the pilosebaceous unit, is influenced significantly by inflammation and oxidative stress, and is commonly associated with obesity. Similarly, obesity is also asso...

    Authors: Ludovica Verde, Evelyn Frias-Toral, Sara Cacciapuoti, Daniel Simancas-Racines, Matteo Megna, Giuseppina Caiazzo, Luca Potestio, Maria Maisto, Gian Carlo Tenore, Annamaria Colao, Silvia Savastano, Giovanna Muscogiuri and Luigi Barrea
    Citation: Journal of Translational Medicine 2024 22:322
    Content type: Research Published on:

  30. Dihydromyricetin (DHM), a flavonoid compound of natural origin, has been identified in high concentrations in ampelopsis grossedentata and has a broad spectrum of biological and pharmacological functions, particu...

    Authors: Yan Yang, Wen Qiu, Jiyuan Xiao, Jie Sun, Xuan Ren and Luxia Jiang
    Citation: Journal of Translational Medicine 2024 22:309
    Content type: Research Published on:

  31. Ulcerative colitisis (UC) classified as a form of inflammatory bowel diseases (IBD) characterized by chronic, nonspecific, and recurrent symptoms with a poor prognosis. Common clinical manifestations of UC inc...

    Authors: Fazheng Yu, Xueyu Hu, HongLin Ren, Xiaoxu Wang, Ruoran Shi, Jian Guo, Jiang Chang, Xiaoshi Zhou, Yuanyuan Jin, Yansong Li, Zengshan Liu and Pan Hu
    Citation: Journal of Translational Medicine 2024 22:308
    Content type: Research Published on:

  32. Over the last decades, the Mediterranean diet gained enormous scientific, social, and commercial attention due to proven positive effects on health and undeniable taste that facilitated a widespread popularity...

    Authors: Justyna Godos, Francesca Scazzina, Corrado Paternò Castello, Francesca Giampieri, José L. Quiles, Mercedes Briones Urbano, Maurizio Battino, Fabio Galvano, Licia Iacoviello, Giovanni de Gaetano, Marialaura Bonaccio and Giuseppe Grosso
    Citation: Journal of Translational Medicine 2024 22:294
    Content type: Review Published on:

  33. Angiopoietin-like protein 3 (ANGPTL3) is secreted by hepatocytes and inhibits lipoprotein lipase and endothelial lipase activity. Previous studies reported the correlation between plasma ANGPTL3 levels and hig...

    Authors: Longyan Yang, Yan Wang, Yongsong Xu, Kun Li, Ruili Yin, Lijie Zhang, Di Wang, Lingling Wei, Jianan Lang, Yanan Cheng, Lu Wang, Jing Ke and Dong Zhao
    Citation: Journal of Translational Medicine 2024 22:263
    Content type: Research Published on:

  34. Albuminuria, the presence of excess of protein in urine, is a well-known risk factor for early kidney damage among diabetic/prediabetic patients. There is a complex interaction between physical activity (PA) a...

    Authors: Bingquan Xiong, Yufan Wang, Juan He, Lisha Wang, Rui He, Min Zhu, Jiaxing Wang, Yingrui Li, Bin Liu, Kaihu Xiao and Qiang She
    Citation: Journal of Translational Medicine 2024 22:252
    Content type: Research Published on:

  35. Flavonoids are a class of secondary plant metabolites that have been shown to have multiple health benefits, including antioxidant and anti-inflammatory. This study was to explore the association between dieta...

    Authors: Runmiao Wu, Xu Zhu, Gongchang Guan, Qianwei Cui, Ling Zhu, Yujie Xing and Jingsha Zhao
    Citation: Journal of Translational Medicine 2024 22:205
    Content type: Research Published on:

  36. Metabolic and bariatric surgery (MBS) is safe and efficacious in treating adolescents with severe obesity. Behavioral/lifestyle programs can support successful preparation for surgery and post-MBS weight loss,...

    Authors: Maral Misserian, Alicia Wheelington, Rashon King, Jackson Francis, M. Sunil Mathew, Marlyn A. Allicock, Bethany R. Cartwright, Adejumoke Adewunmi, Aparajita Chandrasekhar, Dhatri Polavarapu, Faisal G. Qureshi, Sarah E. Barlow and Sarah E. Messiah
    Citation: Journal of Translational Medicine 2024 22:197
    Content type: Methodology Published on:

  37. The morbidity of gestational diabetes mellitus (GDM) is increasing and is associated with adverse perinatal outcomes and long-term maternal and infant health. The exact mechanism underlying changes in plasma f...

    Authors: Haoyi Du, Danyang Li, Laura Monjowa Molive and Na Wu
    Citation: Journal of Translational Medicine 2024 22:180
    Content type: Review Published on:

  39. Proximal tubular cells (PTCs) play a critical role in the progression of diabetic kidney disease (DKD). As one of important progenitor markers, CD133 was reported to indicate the regeneration of dedifferentiat...

    Authors: Yuhan Zhang, Lusi Xu, Congcong Guo, Xianzhi Li, Yutian Tian, Lin Liao and Jianjun Dong
    Citation: Journal of Translational Medicine 2024 22:159
    Content type: Research Published on:

  40. Hidradenitis suppurativa (HS), an inflammatory-based dermatological condition often associated with obesity, poses significant challenges in management. The very low-calorie ketogenic diet (VLCKD) has shown ef...

    Authors: Ludovica Verde, Sara Cacciapuoti, Giuseppina Caiazzo, Matteo Megna, Fabrizio Martora, Annarita Cavaliere, Maria Mattera, Maria Maisto, Gian Carlo Tenore, Annamaria Colao, Silvia Savastano, Giovanna Muscogiuri and Luigi Barrea
    Citation: Journal of Translational Medicine 2024 22:149
    Content type: Research Published on:

  41. Excessive energy intake in modern society has led to an epidemic surge in metabolic diseases, such as obesity and type 2 diabetes, posing profound threats to women’s reproductive health. However, the precise i...

    Authors: Congcong Liu, Yunde Dou, Mengge Zhang, Shan Han, Shourui Hu, Yuxuan Li, Zhiheng Yu, Yue Liu, Xiaofan Liang, Zi-Jiang Chen, Han Zhao and Yuqing Zhang
    Citation: Journal of Translational Medicine 2024 22:145
    Content type: Research Published on:

  42. Bone is a metabolically active tissue containing different cell types acting as endocrine targets and effectors. Further, bone is a dynamic depot for calcium, phosphorous and other essential minerals. The tiss...

    Authors: Amir Mohammad Malvandi, Esra Halilaj, Martina Faraldi, Laura Mangiavini, Simone Cristoni, Valerio Leoni and Giovanni Lombardi
    Citation: Journal of Translational Medicine 2024 22:143
    Content type: Research Published on:

    The Correction to this article has been published in Journal of Translational Medicine 2024 22:303

  43. Overweight is known to be an important risk factor for colorectal cancer (CRC), and the differences in intestinal flora among CRC patients with different BMI status have not been clearly defined. The purpose o...

    Authors: Yongqi Huang, Xiaoliang Huang, Zhen Wang, Fuhai He, Zigui Huang, Chuanbin Chen, Binzhe Tang, Mingjian Qin, Yongzhi Wu, Chenyan Long, Weizhong Tang, Xianwei Mo and Jungang Liu
    Citation: Journal of Translational Medicine 2024 22:142
    Content type: Research Published on:

  44. Overweight and obesity are established risk factors for various types of cancers including colorectal cancer (CRC). However the underlying molecular mechanisms remain unclear. An in-depth understanding of the ...

    Authors: Guozhong Xiao, Yihui Zheng, Huaxian Chen, Minyi Luo, Chaoxin Yang, Donglin Ren, Pengfei Qin, Heng Zhang and Hongcheng Lin
    Citation: Journal of Translational Medicine 2024 22:134
    Content type: Research Published on:

  45. Vitamin D (VD) is implicated in various health conditions, including colorectal cancer (CRC). To investigate potential relationships between pre-chemotherapy VD levels and the time-to-outcome in metastatic CRC...

    Authors: Alessandro Ottaiano, Maria Lucia Iacovino, Mariachiara Santorsola, Sergio Facchini, Domenico Iervolino, Francesco Perri, Guglielmo Nasti, Vincenzo Quagliariello, Nicola Maurea, Andrea Ronchi, Bianca Arianna Facchini, Alessia Bignucolo and Massimiliano Berretta
    Citation: Journal of Translational Medicine 2024 22:119
    Content type: Review Published on:

  46. Converging data have suggested that monocytic inflammation and C-reactive protein (CRP) are biologically intertwined processes and are involved in diabetogenesis. This study aimed to investigate the associatio...

    Authors: Dan Wu, Genyuan Chen, Yulong Lan, Shuohua Chen, Xiong Ding, Chiju Wei, Lois Balmer, Wei Wang, Shouling Wu and Wencan Xu
    Citation: Journal of Translational Medicine 2024 22:110
    Content type: Research Published on:

  47. Atherosclerosis is a chronic, progressive, inflammatory disease that occurs in the arterial wall. Despite recent advancements in treatment aimed at improving efficacy and prolonging survival, atherosclerosis r...

    Authors: Huiling Lin, Ming Zhang, Mi Hu, Yangkai Zhang, WeiWei Jiang, Wanying Tang, Yuxin Ouyang, Liping Jiang, Yali Mi, Zhi Chen, Pingping He, Guojun Zhao and Xinping Ouyang
    Citation: Journal of Translational Medicine 2024 22:97
    Content type: Review Published on:

  48. Obesity, a condition associated with the development of widespread cardiovascular disease, metabolic disorders, and other health complications, has emerged as a significant global health issue. Oleanolic acid ...

    Authors: Tianfeng Liu, Jiliang Wang, Ying Tong, Lele Wu, Ying Xie, Ping He, Shujue Lin and Xuguang Hu
    Citation: Journal of Translational Medicine 2024 22:86
    Content type: Research Published on:

  49. Mediterranean Diet (MD) has many health benefits, particularly in reducing cardiovascular risk (CVR). However, it is still little known if there are any sex differences in following this nutritional pattern an...

    Authors: Luigi Barrea, Ludovica Verde, Rosario Suárez, Evelyn Frias-Toral, Celina Andrade Vásquez, Annamaria Colao, Silvia Savastano and Giovanna Muscogiuri
    Citation: Journal of Translational Medicine 2024 22:44
    Content type: Research Published on:

  50. Dietary sulfur amino acid restriction (SAAR) improves metabolic health in animals. In this study, we investigated the effect of dietary SAAR on body weight, body composition, resting metabolic rate, gene expre...

    Authors: Thomas Olsen, Emma Stolt, Bente Øvrebø, Amany Elshorbagy, Elena C. Tore, Sindre Lee-Ødegård, Hannibal Troensegaard, Hanna Johannessen, Beate Doeland, Anna A. D. Vo, Anja F. Dahl, Karianne Svendsen, Magne Thoresen, Helga Refsum, Russell Rising, Kristýna Barvíková…
    Citation: Journal of Translational Medicine 2024 22:40
    Content type: Research Published on:
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